LOCUS       c00065_gnlPro..        15729 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JNLOKCNI_65.
ACCESSION   c00065_gnlPro..
VERSION     c00065_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 22:55:50
            Original ID  :: gnl|Prokka|JNLOKCNI_65
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15729
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15729
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[406:5729]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      407..5729
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15729
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15729
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             2..208
                     /locus_tag="ctg65_1"
                     /transl_table=11
                     /translation="LRLLYLCSRIRRQVSGIVTSNTLWCADKLILETVLQDRNKKFRRR
                     IVREINLSIHWFAGEGEIRDNTK"
     CDS             407..1843
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_2"
                     /sec_met_domain="CT_Vparvula (E-value: 1.7e-136, bitscore:
                     445.7, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNATQSLAGTRITSLLDANSFVEIGQGVTARSTDFNMTANKAPS
                     DGVITGYGVIDDKLVYVYSQDASVLNGTVGEMHAKKITRLYDLAMKTGAPVIGLVDCAG
                     IRLQEATDALEAFGQIYLKQTLASGVIPQITAIFGTCGGGMAVIPSLTDFTFMESKKGK
                     MFVNTPNALEGNNTDKCDTAAADFQSKETGVIDGVGTEDEILGQIRSLVSLLPSNNEDT
                     DNYTECTDDLNRVCADLANCAGDTAIALSQIADNGEFFETKADYAKDMVTGFIRLNGAT
                     VGAVANRSEVYDAEGKKTETFDGSISARGARKAADFVKFCDAFDIPVLTLTNATGFMAT
                     LCSEKMMAKSVGELVAAFADATVPKVNVIIGKAYGTAYVAMNSKSIGADLVYAWDNAEI
                     GMMDASLAAKIMYADADAAELNEKAAQYRELQNGVASAAARGYVDTVISPADTRKYVIG
                     AFEMLFTKREDRPSKKHGTV"
     CDS             1858..2613
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_3"
                     /sec_met_domain="OAD_gamma (E-value: 1.1e-27, bitscore:
                     86.6, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKMIKKITSVFMTFLVMAALVIGSTSVVFAADKVDDTVKSTLVTT
                     AEGLTDAIVQLKDEEIENYMSSGDDFTTSAMQSWQTSKDELGAKKDSNGETTVTFKDDQ
                     YTVTVPLKFEKAEANFVYVFDSQGTPTSMSVDVQYGMGKTLQRAGLNTLMGIGTVFVML
                     ILLSLLISLFRFIPNPEAKKAAEAKAAKAAKEAEAAAIAQTAPAQAEENLADDGELVAV
                     IAAAIAAAEGTTTDGFVVRSIRKVKRNRR"
     CDS             2641..3009
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63; E-value:
                     6e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.6e-20, bitscore:
                     63.0, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGTAYEVTVEETGSVSAPAAAPKAAPKAAPAAAPKAA
                     APAAGAGAVKVTASVPGKVVKVAASVGQAVKAGDSVVILESMKMEIPVVAPQDGTIASI
                     DVAEGASVENGDTLATMN"
     CDS             3026..4174
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_5"
                     /sec_met_domain="OAD_beta (E-value: 6.7e-157, bitscore:
                     511.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVTETLSNLIHQTAFFNLTWGNYLMIAVACVFLYLAIKKGFEP
                     LLLVPIAFGMLLVNIYPDIMANPEDMSNGVGGLLHYFYILDEWSILPSLIFMGVGAMTD
                     FGPLIANPISFLMGAAAQLGIYAAYFLAIFLGFNGKAAAAISIIGGADGPTSIFLAGKL
                     GQSALMGPIAVAAYSYMSLVPIIQPPIMKLCTTEKERKIKMDQLRPVSKLEKILFPIVI
                     TIVVCLILPTTAPLVGMLMLGNLFRECGVVKQLTETASNALMYIVVILLGTSVGASTSA
                     EAFLNADTLKIVVLGLVAFAIGTFGGCMLGKLLCKLTHGKINPLIGSAGVSAVPMAARV
                     SQKVGAEADPTNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             4317..5729
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_6"
                     /sec_met_domain="HMGL-like (E-value: 5.7e-47, bitscore:
                     150.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 6.4e-59, bitscore:
                     189.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELEKKPVKIVETILRDAHQSQIATRMTTEQMLPIVDKLDKVGY
                     HAVECWGGATFDASLRFLHEDPWERLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSAANGIDIIRIFDCLNDLRNLQTAVSAANKEKAHAQVALSYTLGDAYTLEYWTD
                     IAKRIEDMGADSICIKDMAGLLLPNKATELVTALKETVKIPIDLHTHYTSGVASMTYLK
                     AVEAGVDIIDTAMSPFALGTSQPATEVMVETFKDTPYDTGFDQKLLSEIADYFRPIRDE
                     ALDSGLLNPKNLGVNIKTLLYQVPGGMLSNLTSQLKEQHAEDKFYDVLEEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKMVTKETKDILLGKYGATVKPFNPEVQKKCIGD
                     EKPITCRPADLLDNELEKLESEMAQYKEQDEDVLTYALFPQVAMDFFKYRQAQKTKVDE
                     KAADKKNGAYPV"
     CDS             5841..7301
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_7"
                     /sec_met_domain="HI0933_like (E-value: 1e-128, bitscore:
                     419.5, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPEVHIYIDRSEAETWNHDEIDNLQGKINTGEYSMSKVIIIGGG
                     AAGMMAGVFAARNHHEVHILEKNEKLGKKVFITGKGRCNVTNACDTEELFPAMMSNPKF
                     LYSSFYSFTPQDVMEFFEKAGVPLKVERGNRVFPQSDHSSDIIRALERELKKAGAKIHL
                     HTAVQEIVKKPVTESVTDSVNTLESEAALTESGSDAGKSRKGKKSSDIQQEKITGVILT
                     DGTFIEGDAVIVATGGFSYQSTGSTGDGYRFARELGLKVTDIAPSLVPLKTKEDYIPKL
                     QGLSLKNTGLTIKNGKKVLYEDFGEMMFTHFGVTGPMILSASAHIGAKLAKAPNGELSA
                     YLDLKPALTREQLDARILREFEAGPNKQFKNVIGVLFPSSLTPVMLELGGIPAEKKIHD
                     ISREERQHFIDLIKAFPFTITGMGEFKEAIITRGGVSVKEINPGTMESKKISGLYFAGE
                     VLDLDAVTGGYNLQIAWSTAYLAAQAIQ"
     CDS             7450..8121
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytidylate_kin"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_8"
                     /sec_met_domain="Cytidylate_kin (E-value: 2.7e-78,
                     bitscore: 252.6, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGCNIAIDGPAGAGKSTIAKKVAKELSFIYVDTGAMYRAMALYLL
                     NHGVNGENQEEIEAVCSGADISIEYKNGEQIVILNGENVNAMIRTEQVGNMASKSSANP
                     KVRAHLLKLQRTLAEKNDVVMDGRDIGTTILPNAEVKIYLTASADTRAKRRALEYEQKG
                     ESFDLDQIRKDIIERDERDMNREISPLKQAEDAVLVDSSEMGIDDVVNAILNVYKEKVQ
                     K"
     CDS             8278..9156
                     /locus_tag="ctg65_9"
                     /transl_table=11
                     /translation="MKVKVAETAGFCFGVKRAVDKVYELIDTEQKPIFTLGPIIHNEGV
                     VADLEARGVHVITEADLDSPDDTLQNGTVVIRSHGVGKAIYDKLKEKNISYVDVTCPFV
                     LKIHRIVEKESLAGNHIIIIGDKDHPEVQGICGWCQGPYTVIGNKEEAEAFVPPKGKKI
                     SIVSQTTFNYNKFKDLVEILCKKRYDNNVLNILNILNTICNATEERQREAKNIAGEVDT
                     MLVVGGRHSSNTQKLFEICKKECGNTYYIQTPVDLDSEMFQCSSYVGITAGASTPNKII
                     EEVQEHVRIKF"
     CDS             9137..10213
                     /locus_tag="ctg65_10"
                     /transl_table=11
                     /translation="MSELSFEQMLEDSVKTIRNGEIVQGTVIDVKEDEIILNIGYKADG
                     IITKNEYSNDASLVLTDAVHVGDTMEAKVLKVNDGEGQVTLTYKRLAAEKGNKRLEEAF
                     ENQEVLKAPVTQVLDGGLCVNVDEARVFIPASLVSDTYEKDLSKYADQEIEFVITEFNP
                     RRRRIIGNRKQLLLAEKAEKQKELMEKIHVGDTVEGTVKNVTDFGAFIDLGGADGLLHI
                     SEMSWGRVENPKKVFTVGDKVKVLIKEINGEKIALSLKFPEANPWLTAAEDFAVGNVVK
                     GKVARMTDFGAFVELAPGVDALLHVSQISREHVAKPSDVLSIGQEIEAKVVDFNGEDKK
                     ISLSMKALEAPAEEATEE"
     CDS             10361..11107
                     /locus_tag="ctg65_11"
                     /transl_table=11
                     /translation="MSIKGIYDIHCHIVPGVDDGATDIGETVKLLRMEYEQGVRTVIAT
                     PHFRFRMFETPAEKVREQFRLVEKAASEISPDLHVYLGCEFHANMEMLPMLREQKVMTM
                     AGSRYVLTEFSHNSEESYMRERLGALLSGGYKPIMAHIERYEATRNSLDFVEELADMGV
                     YMQINADSITGKDGFFTKRYCNKIMKDGLLHFVGSDCHNSAKRSSRIGEAYRMVSAKFG
                     QDYADELFIHNPAEILKQKQKHEATD"
     CDS             11248..12027
                     /locus_tag="ctg65_12"
                     /transl_table=11
                     /translation="MLDNLNSNFESSKAQRPDANDDEVEIDLLEIFYALKKKILLVLMV
                     ALVGGCIAAAYTQFLMTPIYSSTSSILVLSKETTLTSLADLQLGASLTSDYTVLITSTP
                     VMEQVISDLDLDMTAEQLKGSVSINNPTDTRILEITVNNTDSKMAKKIVDEIANVSSSY
                     IGDKMEVIPPKIIEVGKIATVRTSPSVKKNAALGFLLGFLACAAIVVVYAVMDDTIKTE
                     EDIEKYLGVSVLAKVPDRKDFINSKNRKSKNKNKKHH"
     CDS             12049..12759
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CbiA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_13"
                     /sec_met_domain="CbiA (E-value: 4.7e-09, bitscore: 26.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLNLTDKRNPDYFYSEAIKTLRTNIQLSGQSIKTILVTSCYPN
                     EGKSDIVLSLAQELGSIGKKVLLLDADIRKTAYAGRLGVEEEVKGLSQLLSGQVGLQEV
                     IYSTNFPNMDIIFGGPNAPNPSGLLSENIFKVFLKEIREYYNYILIDTPPIGTVIDAAV
                     IGRCCDGAVFLIEPGNVRYRDAQKAFKQLERSGCRILGAVMNKIDTSDDKYYSSYYKHY
                     GEYYRRSDEEAQIK"
     CDS             12823..13785
                     /locus_tag="ctg65_14"
                     /transl_table=11
                     /translation="VSKIRNKKIKKTNILLGFICILLAVLLGFILVTSYKSEQKESRHL
                     SEIADDQQSGIEDYEAVKERAKELEEISSEEAEDTEDIKSKNTEDTKDTEKTDTADTED
                     ADKTEDTKDATAAASGIVCWGDDLINGEESNTYSYMTVLQKLLTDNGYNMTVLNKTLQG
                     GGTLSMMKMAGVSDETIQSYITKHQQAANGAQLNVTETGIRDLTEEQTTRNDMDCIPVI
                     FMGYYGGWNHDPAELADQQEQILNTFQNKDQFIVVGTRPMDGSVTSEALDQVLSQKWGE
                     HYISLADVTAQPSSTYEAQQAMAEAILQKLQELNYISKN"
     CDS             13822..14853
                     /locus_tag="ctg65_15"
                     /transl_table=11
                     /translation="MKKTTRKAIRQRKICMLLIIILIIVLSILGGGYYLLSQKNVASSK
                     VGGQNSDSRNQTDLNQNSDTVEYKGETYKYNDHLSNYLFLGIDTRETVDTYQSQADAGQ
                     ADAIFLVSMDRATEKIKVLFIPRDSMTRIEVFNPYGQSLGETTDHLNIQYAFGDGKEKS
                     CELMKTAVSDMLDGLPIQGYCSMNMDGISVITDFVGGIQLTIPDDSLADVNPEYKKGAV
                     VDITGETAEQFVRYRDIDKTQSALVRQERQKTFLQALVQKAQEKAGEDAGFVTGLYDSV
                     KSYTVTNMGNDIFAKLLAASQNGITDTETVPGEGTHGENFDEYHIDEDALSDLIISMFY
                     EKI"
     CDS             14994..15620
                     /locus_tag="ctg65_16"
                     /transl_table=11
                     /translation="MKIAKKFMTLALAAALGVGCATVGVGAAPSNTSDLAAVAPSRTSE
                     TTVDSEHSSIYEVVKELEKTQGFADLQAKYKDLADAFKQINDGTMKMEDFIKVLKSLSV
                     DEADKADLEDAIAKLEGKMIVTFVNEFNVLKPEEAKPNDDGTYEVKLNVPSLTDTMEGI
                     QLWVYSKDGTKKFVVIDPVNIDKEGKTLTVNLNDGDFFMVIADAK"
ORIGIN
        1 gctgagactt ttatacctgt gtagtcggat tcgcagacaa gtgagtggta tagttacctc
       61 aaacacgctc tggtgtgccg acaagttgat tcttgaaaca gtcttgcagg atagaaataa
      121 gaaattcaga cgcaggattg ttcgagaaat caacttgtcg atacactggt ttgcgggaga
      181 gggtgaaata cgggacaata caaaataacc gtaataccct ctattaaata ggaagaaatg
      241 ctcaaaaaaa caaaatttgg agaaacctga caaatttttc tgctatattt ttaacgaaaa
      301 tgacaaataa atgttgaaat tttctgccgg aaaaggtaaa attaaaatcg gctaaatttt
      361 tgggttaact tttaaatatt ctcataaaga tggagggcaa acaagaatga gtaatgcaac
      421 acaaagctta gcaggcacaa gaattacttc tttgcttgac gcaaacagtt ttgtcgaaat
      481 cggacagggt gtaacagcca gatccacaga tttcaacatg actgcaaaca aggcaccatc
      541 tgacggtgtt atcaccggat atggtgtgat cgatgacaaa ctggtttatg tatacagcca
      601 ggatgcatct gtattaaacg gtactgttgg tgaaatgcat gcaaagaaga tcacaagact
      661 ttatgatctt gccatgaaaa caggcgctcc ggttatcgga cttgttgact gtgcaggtat
      721 ccgtcttcag gaagcaacag acgcactgga agctttcgga cagatctatc tgaaacagac
      781 actggcatcc ggtgtgatcc cgcagatcac agcaatcttc ggaacatgcg gcggtggtat
      841 ggcagttatc ccgtccctga cagatttcac attcatggaa tccaaaaaag gaaaaatgtt
      901 cgtcaacaca ccaaacgcac tggaaggaaa caacacagac aaatgcgaca cagcagcagc
      961 tgatttccag agcaaagaga caggtgtgat tgatggcgtt ggtacagagg atgagattct
     1021 tggccagatc cgttccttag tatcacttct tccttctaat aatgaagaca cagacaatta
     1081 cacagagtgt acagatgatc ttaaccgcgt atgcgcagat cttgcaaact gtgcaggtga
     1141 cacagcaatc gcactttccc agatcgctga caacggtgaa ttcttcgaga caaaagcaga
     1201 ctatgcaaaa gacatggtta caggctttat ccgtttaaac ggcgctacag taggtgctgt
     1261 tgcaaacaga agcgaagtat atgacgcaga aggcaagaaa acagaaacat ttgacggaag
     1321 catctctgca agaggcgcaa gaaaagcagc agatttcgtg aaattctgcg acgcttttga
     1381 tattccggta cttacactta caaacgcaac aggcttcatg gcaaccttat gcagcgagaa
     1441 gatgatggcg aaatccgtag gtgaactggt agctgcattc gcagatgcaa ctgttccgaa
     1501 ggtaaatgtg atcatcggca aagcttacgg tacagcttac gtggcaatga acagcaaatc
     1561 tatcggtgca gaccttgtat atgcatggga taacgcagag atcggtatga tggatgcttc
     1621 cctggcagcc aagatcatgt atgcagatgc agatgctgct gaactgaatg aaaaagctgc
     1681 tcagtacaga gagcttcaga atggtgttgc ttccgcagca gcaagaggct atgttgacac
     1741 tgtgatcagc ccggctgaca caagaaaata tgtaatcggt gcatttgaga tgctgttcac
     1801 aaagagagaa gatcgtccgt ctaagaaaca tggaacggtc taagcggggt gacgcatatg
     1861 aaaatgatca aaaaaataac ttctgtattc atgacatttc tcgtaatggc tgcgctggtg
     1921 attggcagca cctctgtggt atttgccgca gataaggttg atgatactgt taagtccaca
     1981 ctggtaacta cagcagaagg actgacagat gccattgtcc agcttaaaga tgaagaaatc
     2041 gagaattaca tgagttcagg agatgacttt acaacaagtg ccatgcagtc ctggcagaca
     2101 tccaaggatg aacttggcgc aaagaaggac agcaatggtg aaactactgt aactttcaaa
     2161 gatgatcagt acacagttac tgttcctctt aaatttgaga aagcagaagc aaactttgta
     2221 tatgtctttg actcacaggg aacaccgact tccatgtctg tagatgtaca gtatggtatg
     2281 ggcaagactc ttcagagagc aggtcttaat actctgatgg gtattggaac tgtattcgta
     2341 atgctgattt tattaagcct tctgatttct ctgtttagat ttattccgaa tccggaagca
     2401 aagaaagcag cagaagcaaa agcagccaaa gctgcaaaag aggcagaggc agcagccatc
     2461 gcacagacag cacctgcaca ggcagaagag aaccttgcag atgacggaga gctggtagct
     2521 gttatcgcag cagctatcgc agcagcagaa ggaactacaa cagatggctt cgtagttcgt
     2581 tccatccgta aagtaaaaag aaatagaaga taattgtcat ttatttagga ggattttaaa
     2641 atgaaaagct atacaattac agtaaatggt acagcatatg aagtaactgt tgaagaaaca
     2701 ggaagcgtat ccgctcctgc agcagctcca aaagcagcac ctaaggctgc acctgcagca
     2761 gctccgaaag cagcagctcc tgcagcaggc gccggcgcag tgaaagtaac tgcttccgta
     2821 cctggtaaag ttgtcaaagt agcagcaagc gttggacagg cagtaaaagc cggagacagc
     2881 gtagttattc ttgaatccat gaaaatggaa atccctgtag tagctcctca ggatggtact
     2941 atcgcaagca ttgatgttgc agaaggtgcc tctgtagaaa acggagatac tttagcaaca
     3001 atgaactaag acgggaggta gtcaaatgtc ttatgtaaca gaaacattgt ccaacctgat
     3061 tcaccagaca gcattcttca atctgacatg gggcaattac ctgatgatcg cagtagcctg
     3121 cgtattcctt taccttgcta tcaagaaggg attcgagccg cttctgcttg ttcctatcgc
     3181 attcggtatg ctgcttgtaa atatctatcc ggacattatg gcaaacccgg aagatatgtc
     3241 caatggtgta ggtggacttc ttcattattt ctacatcctt gatgagtgga gtatcttacc
     3301 atccctgatc ttcatgggtg taggtgccat gacagacttc ggtccgctta tcgcaaaccc
     3361 gatcagcttc ctgatgggtg ctgcagcaca gcttggtatc tatgcagctt acttccttgc
     3421 aatctttctt ggattcaacg gaaaagcagc agcagctatc tccatcattg gtggtgctga
     3481 cggcccgact tccattttcc ttgcaggtaa acttggacag tctgcactga tgggaccgat
     3541 cgcagtggca gcatattcct atatgtcact ggttccgatc atccagccgc ctatcatgaa
     3601 actctgcaca acagagaaag aacgtaagat caaaatggat cagcttcgcc cggtttccaa
     3661 actggagaag atcctgttcc cgatcgttat cacaatcgtt gtctgcctga ttttgcctac
     3721 aacagctccg ctggttggta tgctcatgct tggtaacctg ttcagagagt gcggtgttgt
     3781 aaaacagctg acagaaacag cttccaatgc cctgatgtat atcgtagtta tccttctggg
     3841 tacatccgta ggtgcttcca caagtgcaga agcattctta aacgcagata ctctgaagat
     3901 cgtagtttta ggtcttgttg cattcgcaat cggtacattc ggcggatgta tgcttggtaa
     3961 actgctctgc aaactgactc atggaaagat caacccgctg atcggttccg caggtgtatc
     4021 cgcagtacct atggcagccc gtgtatccca gaaagtgggt gcagaggcag atcctacaaa
     4081 cttccttctg atgcatgcaa tgggcccgaa cgttgccggt gttatcggta cagccgtagc
     4141 agccggaaca ttcatggcta ttttcggagt ataaccaaat caagcaagct atcttgcttg
     4201 tatcaggagg agtgcaactc cttctgataa gctgcggagc agctatttgg ttatgagcaa
     4261 gtagcgaagc ggattgcgaa tatccgatta aacagaaata taaaggagat ttaataatgg
     4321 cagaattaga gaaaaaacct gttaaaattg tggaaaccat tctccgtgat gctcatcagt
     4381 cccagatcgc aacacgtatg accacagaac agatgcttcc gatcgtagat aaacttgata
     4441 aagtcggcta tcacgcagta gagtgctggg gtggtgcaac attcgatgca tcccttcgtt
     4501 tccttcacga agatccatgg gaaagacttc gtaaattacg tgacggcttc aaaaacacaa
     4561 aacttcagat gcttttccgt ggacagaaca tccttggata ccgtccatac gcagatgacg
     4621 ttgtagaata cttcgtacag aaatctgctg caaacggaat cgacatcatc cgtatttttg
     4681 actgcctcaa tgaccttcgt aacctgcaga cagcagtaag cgctgcaaac aaagagaagg
     4741 ctcatgcaca ggtagctctt tcctacacat taggagatgc ttacacactg gaatactgga
     4801 cagacattgc aaaacgtatt gaagatatgg gcgctgattc catctgtatc aaagatatgg
     4861 caggtcttct ccttccaaac aaagctacag agcttgtaac agcattaaaa gaaacagtta
     4921 agatcccgat cgaccttcat acacattaca cctcaggtgt agcttccatg acttacttaa
     4981 aagcagtaga agcaggtgtg gatatcatcg atacagcaat gtctccattt gcactgggaa
     5041 catcccagcc tgcaacagag gttatggttg agacattcaa agatacacca tacgacacag
     5101 gatttgatca gaagcttctc tccgagatcg ctgactactt ccgtccaatc cgtgacgaag
     5161 ctcttgacag cggactgctc aatcctaaga accttggtgt taacatcaaa actttactgt
     5221 accaggtacc gggcggtatg ctctccaacc tgacttccca gttaaaagaa cagcacgcag
     5281 aagacaaatt ctacgatgtt ctcgaggaag ttccgcgtgt acgtaaagac cttggtgaac
     5341 cgccacttgt tactccgtct tctcagatcg ttggtacaca ggctgtattc aacgtactta
     5401 tgggcgagag atacaaaatg gttacaaaag aaacaaaaga tatcctgtta ggaaaatacg
     5461 gcgcaactgt aaaaccgttt aatccggaag tacagaagaa gtgcatcggc gatgagaaac
     5521 cgatcacatg ccgtcctgca gaccttcttg acaacgagct tgagaaactt gagagcgaaa
     5581 tggctcagta caaggaacag gatgaagacg tattaacata cgcactgttc ccacaggtag
     5641 ctatggactt cttcaaatac cgtcaggctc agaaaacaaa agttgacgag aaagcagctg
     5701 acaaaaaaaa cggagcatat cctgtataat tgatcagtaa ttaaatatgt ccaaacgaaa
     5761 aaaggagctt gcgcaagcag gctcctttgc gttattatga aagaatatga tacccgggaa
     5821 tataatgtgc caatggttat atgctgccag aggtacatat ctatattgat cgtagcgaag
     5881 cggagacgtg gaaccatgat gaaatagaca atctgcaggg taaaataaat acaggagaat
     5941 attccatgag caaagttata ataatcggcg gcggagccgc cggaatgatg gcaggggttt
     6001 ttgcagcccg taaccatcat gaagttcata tattagagaa gaacgagaaa ctgggaaaga
     6061 aagttttcat cacaggaaaa ggcagatgca atgtgacaaa tgcttgcgac acagaagaac
     6121 tctttcctgc aatgatgagc aatcccaagt tcctctacag cagtttctat tcatttaccc
     6181 ctcaggatgt aatggagttc tttgagaaag caggtgtccc tctgaaggta gagcgtggaa
     6241 acagagtatt cccacagtct gaccattctt cagacatcat ccgcgctctg gagcgtgagc
     6301 tgaagaaagc aggagcaaag attcatcttc atactgctgt gcaggaaatc gtaaagaaac
     6361 ctgtaacgga atctgtaaca gattccgtaa atacccttga atcagaagcc gcattaacag
     6421 aatcaggatc tgatgcagga aaaagcagaa aaggaaaaaa atcatctgac atacagcagg
     6481 agaagatcac aggagttata cttacagatg gtactttcat agaaggcgat gcagtcatcg
     6541 tggcaaccgg cggattctct tatcagagta caggctccac aggtgacgga taccgcttcg
     6601 caagagaact gggactgaaa gtcacggaca ttgctccctc ccttgtgcca ttaaagacaa
     6661 aagaagacta tatccctaag cttcagggac tttcccttaa gaatacagga cttaccataa
     6721 agaatggaaa aaaagtactt tacgaggatt tcggagagat gatgttcacc catttcggag
     6781 tcacaggtcc aatgatcctc tccgccagtg cccacatcgg tgcaaaactg gcgaaagcac
     6841 caaacggcga actgtccgca tatctggatc tgaagcctgc actcaccaga gaacaactgg
     6901 atgccaggat cctgcgtgaa tttgaagcag gaccaaacaa acagttcaag aatgtgattg
     6961 gcgtactttt cccgtcatct ctgactccgg taatgctgga actgggtgga atccccgcag
     7021 agaagaaaat ccacgacatc tccagagaag aacgccagca cttcattgac cttatcaaag
     7081 ccttcccctt cacaatcaca ggaatgggtg agttcaaaga agccatcatc accagaggcg
     7141 gcgtctctgt caaagagatc aaccccggaa caatggaatc aaagaaaatc tcaggtcttt
     7201 acttcgcagg cgaggtactg gatctggatg cagtgacagg tggatataac ttacagattg
     7261 cctggtctac cgcatatctg gcagcacagg ctatacagta agctgaaaca agcagatgat
     7321 gagtaccttg taggtggatt atatctatga tatgattcag ctatacgtta tttaacgatt
     7381 cataaacatc aatcaataat aaaacagaga aaatctgttt gaataataga aacaggagga
     7441 accacgaaaa tgggatgtaa catagccatc gacggacctg caggagcagg aaagagcacc
     7501 atcgcaaaga aagtagcgaa agaattatca tttatctatg tagatacagg agccatgtat
     7561 agggcaatgg ctttatatct tctgaaccat ggcgtaaacg gagaaaatca ggaagagatc
     7621 gaagccgtat gttccggcgc tgacatctcc atcgaataca aaaacggaga acagattgtc
     7681 atcctcaacg gagagaacgt aaatgctatg atccgcaccg aacaggtagg aaacatggca
     7741 tccaaaagct ccgcaaaccc gaaagtcaga gctcatcttc tgaagcttca gagaactctg
     7801 gcagagaaaa acgacgtagt catggacggc agagatatcg gcacaaccat ccttccaaac
     7861 gcagaagtaa aaatctacct cacagcaagc gcagacacca gagcaaaaag aagagcactg
     7921 gaatatgaac agaagggaga atccttcgac ctggaccaga tacgaaaaga catcattgag
     7981 cgcgacgaac gcgacatgaa ccgcgaaatc tcccctctga aacaggcaga ggacgcagtg
     8041 cttgtagatt cttcggaaat gggaattgat gatgttgtca atgcaattct taatgtatat
     8101 aaagaaaagg tgcagaaatg atcagataac tgcctgtagt tcatcagaag atgacacacg
     8161 caaagatatc tgacacagga tttcacgctc tgatgagttg gattaagata cattatttca
     8221 gaggattgct ataaattcca gaagaatggc aatgaatata aattaagagg attagtaatg
     8281 aaagtaaaag tagcagaaac agcaggcttc tgcttcggcg tcaaacgtgc agtggacaaa
     8341 gtctacgagc tgatcgacac agaacagaaa ccaatcttca ctctgggtcc gatcatccac
     8401 aatgaaggtg tagtagcgga tctggaagcc cgtggcgtcc acgttatcac agaagcagac
     8461 ctggattccc cggatgacac cctgcagaac ggaacagtag tcatccgctc tcacggtgta
     8521 ggcaaagcca tctacgataa gctgaaagaa aaaaacatct cttatgtaga tgtgacctgc
     8581 cccttcgttc tgaaaatcca caggatcgtg gaaaaagaaa gccttgcagg aaaccacatc
     8641 atcatcatcg gcgacaaaga ccaccccgaa gtacagggca tctgcggctg gtgtcaggga
     8701 ccgtacacgg tgatcggaaa caaagaagaa gccgaagcat ttgtacctcc aaaaggcaaa
     8761 aaaataagta tcgtgtccca gacgacattt aattacaaca aatttaaaga tttagttgaa
     8821 attctttgca aaaagaggta tgataataat gttttaaata ttctcaatat tttaaacact
     8881 atttgtaatg ctaccgaaga acggcagaga gaagcaaaaa acatagccgg agaggtagac
     8941 actatgttgg tcgtaggtgg ccggcacagt tccaatactc aaaagctgtt tgaaatatgt
     9001 aaaaaggaat gtggaaatac ttactatata caaacacctg tagacttgga ttctgaaatg
     9061 ttccaatgca gtagttatgt aggtattaca gcaggggctt ccaccccaaa caaaattatt
     9121 gaggaggttc aagaacatgt cagaattaag ttttgaacaa atgctggaag attccgtaaa
     9181 gactatcaga aatggagaga ttgtacaggg tactgtcatc gatgtaaaag aagatgagat
     9241 tattctgaat atcggttata aagcagacgg tattatcaca aagaacgaat actctaacga
     9301 tgcaagcctt gtactcacag atgctgttca cgttggagac acaatggaag caaaagttct
     9361 caaagtaaac gatggagaag gtcaggtaac tcttacttat aagagactgg cagcagagaa
     9421 aggcaacaaa cgtcttgaag aagcatttga gaatcaggaa gtattaaaag ctcctgtaac
     9481 tcaggtactt gacggcggac tctgtgtaaa cgtagacgaa gcaagagtat tcattcctgc
     9541 aagcctcgtt tccgacacat acgagaaaga cctttccaaa tatgcagatc aggagatcga
     9601 attcgttatc acagaattca acccgagaag acgccgcatc atcggtaacc gtaagcagct
     9661 ccttcttgct gagaaagcag agaaacagaa agaattaatg gagaagatcc atgttggcga
     9721 cacagttgaa ggaacagtta agaacgttac agatttcggt gcattcatcg atcttggcgg
     9781 agcagacgga cttcttcaca tctccgaaat gtcctggggc agagtagaga acccgaagaa
     9841 agtattcact gttggcgata aagtcaaagt tcttatcaag gagatcaacg gagagaagat
     9901 cgcactttcc cttaaattcc cggaagcaaa tccatggctc acagcagctg aggacttcgc
     9961 tgtaggaaac gtagttaaag gtaaagttgc acgtatgaca gacttcggtg cattcgtaga
    10021 gcttgcacct ggtgtagatg cacttcttca tgtatcccag atttccagag agcacgttgc
    10081 caaaccttca gacgtacttt ccatcggaca ggagatcgaa gctaaggttg ttgacttcaa
    10141 cggcgaagac aagaaaatca gcctgagcat gaaagctctt gaggcaccgg ctgaggaagc
    10201 tacagaagaa taattaagag aatactcata aatattcagc aaccggcttt gtatgaggat
    10261 gatcatacag agccggttga ttgttttttt agattacgaa tgtggtcagc agttacagga
    10321 gcatcagaaa tgctgcagac agtcaggaag gaattatagg atgtccataa aaggaattta
    10381 tgatatacac tgtcatattg tacccggtgt agacgatgga gccacagata taggagaaac
    10441 cgtaaaatta ctccggatgg aatatgaaca gggcgtgcgg acggttattg caactcccca
    10501 tttccgcttt cggatgtttg aaacacctgc ggagaaagtc agagagcagt tcagactggt
    10561 ggagaaagcg gcatcagaga tcagcccgga tctccatgtg tatctgggat gtgagtttca
    10621 cgccaatatg gagatgcttc ccatgctcag agaacagaaa gtaatgacaa tggccggttc
    10681 acggtatgtt cttacagaat tttcccataa ctcggaagaa agctatatgc gggaacgtct
    10741 cggtgcattg ctctccggag gatataagcc gatcatggca catatagaac gttacgaagc
    10801 tacacgcaac agtctggatt ttgtggaaga actggcagat atgggcgtct atatgcagat
    10861 taatgcagac agcatcacag gaaaagacgg attttttact aaacggtact gtaataaaat
    10921 catgaaagac ggactccttc atttcgtcgg atcagactgt cacaacagtg caaagaggag
    10981 cagcaggatt ggagaggcat atcgtatggt ttcagcgaaa ttcgggcagg actatgcaga
    11041 tgaactgttt attcataatc ctgcagaaat tctgaaacag aaacaaaaac atgaggctac
    11101 agattgactt tttttattgg ctgatataca ataaaatcgg tttatgtcaa ttttgctgtt
    11161 tactttcaga aatacataag acagaatatt acctgtgaac agtaatgtac aaaactataa
    11221 agaaaaaagg gaaaaggaaa ttatcagatg ttagacaatt tgaacagtaa ctttgagagc
    11281 agcaaagcac agagacccga tgcaaatgat gatgaagtcg aaatcgactt actggaaata
    11341 ttttatgcgc tcaagaaaaa aatccttctg gtactgatgg ttgctcttgt cggaggctgt
    11401 attgcagcag catatacgca gtttttaatg acaccgatct acagctccac atccagtatc
    11461 cttgtacttt cgaaagaaac cacactgaca tcactggcgg atctgcagtt aggtgccagc
    11521 ctgaccagtg attatacagt tctgatcaca agtacccctg tgatggaaca ggtgatttca
    11581 gatttggatc tggatatgac tgcagaacag ctgaaaggaa gcgtaagtat caataatcct
    11641 acagataccc gtatccttga gattactgtc aataatacag attctaaaat ggcaaagaag
    11701 atcgtagatg agattgcgaa tgtttcttca tcctatattg gcgataaaat ggaagttatt
    11761 ccgccaaaga ttattgaagt tggtaagatt gctactgtaa gaacttctcc aagcgtaaag
    11821 aagaatgcag cactcggctt cttactcggt ttccttgcat gtgcggcaat cgtggttgta
    11881 tacgctgtaa tggatgatac tattaagaca gaggaagata ttgagaaata cctgggagtt
    11941 tctgttcttg ccaaggttcc tgacagaaaa gattttataa attcgaagaa caggaaatca
    12001 aagaacaaga ataagaagca ccattaaact gatggaggaa tctgagcaat gaagaaactc
    12061 aatttaacag ataaaagaaa tccggattat ttttacagtg aggcgatcaa aactctgcgt
    12121 accaatattc agctgtcggg tcagagcata aagacaattc tggttacaag ctgttatcca
    12181 aacgaaggta agagtgatat agtactcagt cttgcccagg agcttgggag cattggcaag
    12241 aaggttctcc ttctggatgc ggatatcagg aagactgcat atgccggacg actgggtgtg
    12301 gaagaggaag tgaaaggtct ctcacagctt ctgagcggtc aggtgggatt acaggaggtt
    12361 atttattcta caaactttcc gaatatggat atcatattcg gaggtccaaa tgcaccgaac
    12421 ccgtcaggac ttctcagtga gaatatcttt aaggtattct taaaggaaat cagagaatat
    12481 tataattata tcctgatcga tacaccgcct atcggaacag taattgatgc ggcagtgatc
    12541 ggaagatgct gcgatggtgc agtctttctg atcgaaccgg gaaatgtcag gtaccgggat
    12601 gcacagaaag catttaaaca gttggaaaga agcggatgcc gtattcttgg agctgttatg
    12661 aacaagatag ataccagtga tgacaaatat tattcttctt attataagca ttatggagag
    12721 tattatcgca gaagtgacga agaagcccag attaaataat acgggctgtt atctggcagt
    12781 aagacagaaa ccatgattaa tgataaagga gaatttggaa aagtgagcaa aataaggaat
    12841 aaaaaaataa aaaagacgaa tatcttactg ggctttatct gcattctgct ggcagttctc
    12901 ctgggcttta ttcttgtgac cagttataaa tcggaacaga aggaatccag acacctgtca
    12961 gaaattgcgg acgaccagca gagtgggatt gaagattacg aagcagtaaa agaacgtgca
    13021 aaagagctgg aggagatatc ttccgaagaa gcagaagata cagaagacat taaatcaaag
    13081 aacacagaag acacaaaaga cacagaaaaa acggatacag ctgacacaga agatgcagat
    13141 aagacagaag atacaaaaga tgcgacggca gctgcttcag gtattgtgtg ctggggagat
    13201 gatctgatca atggggaaga atccaataca tattcctata tgacagtact tcagaagctt
    13261 ctgaccgata atggctataa tatgacagtg ctcaataaaa cgcttcaggg aggcggcact
    13321 ctctccatga tgaagatggc tggtgtaagt gatgaaacta ttcagagcta tattactaaa
    13381 catcagcagg ctgcaaacgg tgcccagctg aatgtaacag agaccggaat acgtgatctg
    13441 acagaagaac agactacaag aaatgatatg gattgtattc ctgttatctt catgggctat
    13501 tatggcggct ggaatcatga tcctgcagaa ctggcagacc agcaggaaca gattttaaat
    13561 acatttcaga ataaagatca gtttattgta gtaggaacac gccctatgga cggaagcgta
    13621 acctctgaag cactggatca ggtgctcagc cagaaatggg gagaacacta tatcagtctt
    13681 gcagatgtga ctgcacagcc gtcttctacc tatgaggctc agcaggcaat ggcagaggca
    13741 atattacaga aattgcagga gcttaattat atcagcaaaa actgatgaga taactgaaat
    13801 acagagattg aaggaatgaa aatgaaaaaa accacaagaa aagccatcag acagcgtaag
    13861 atctgtatgc ttttgattat tatcctgatc atagttcttt ccattcttgg cggcggttat
    13921 tatctgttaa gccagaaaaa tgttgcatcg tcaaaagtcg gcggtcagaa cagtgacagc
    13981 cggaatcaga cggatttgaa ccaaaacagt gataccgtgg aatataaagg tgagacatac
    14041 aaatataacg atcatctcag caattattta ttcctgggaa ttgatacaag ggaaactgta
    14101 gatacttatc agtcacaggc agatgccggg caggcagatg caattttcct ggtgtccatg
    14161 gatcgtgcaa cagaaaagat aaaagttctg tttattccac gagattccat gaccaggata
    14221 gaagtattta atccatatgg tcagagcctt ggagagacaa cagatcatct gaatatacag
    14281 tatgccttcg gggacggaaa agagaaaagc tgtgaactga tgaaaacagc agtttccgat
    14341 atgctggatg gacttccgat ccaggggtat tgttccatga acatggatgg catttcagtg
    14401 attacagatt tcgtaggtgg aatacagctc acaatccctg atgacagtct cgcagatgtg
    14461 aatccggaat ataaaaaagg tgctgttgtg gatattacag gggaaactgc agaacagttt
    14521 gtaagatatc gtgatattga caaaacccag agtgctctgg tccgtcagga gagacagaaa
    14581 acctttcttc aggcactggt gcagaaggct caggaaaaag caggagagga cgccggattt
    14641 gtgacaggtc tctatgacag tgttaaaagc tatacagtta caaatatggg aaatgatata
    14701 tttgccaaat tgctggctgc atcacagaat ggaatcactg atacagagac agtaccgggt
    14761 gagggaacac atggggagaa ctttgatgag tatcatatcg atgaagatgc attgtcagat
    14821 ttgattattt ccatgtttta tgagaaaatt tgattgtatt agtcatagta tgatgaatac
    14881 agaatacact gtactgtgat aaataattat cactgttatt attcagagat agtccgtgca
    14941 gacattctgt acggttatct atataaaaat taatccaaaa ggagaggtgc attatgaaaa
    15001 tcgcaaagaa atttatgaca cttgctttag cagctgccct tggagtagga tgtgctactg
    15061 taggtgtcgg tgcagcgcca agcaacacga gtgatctggc cgcggtagcg ccaagtagga
    15121 caagcgaaac tactgtggat tctgaacatt cttcaattta tgaagttgtt aaggaacttg
    15181 agaaaacaca gggctttgct gatctgcagg caaaatataa agatctggca gatgctttta
    15241 aacaaatcaa tgatggaaca atgaagatgg aagatttcat aaaagtattg aaatcccttt
    15301 ccgtagatga agcagacaaa gcagaccttg aagatgccat tgctaaactc gaaggaaaaa
    15361 tgattgttac atttgtcaat gaattcaacg tactgaagcc agaagaagca aagcctaatg
    15421 atgacggaac atatgaagta aagcttaatg ttccgagtct tacagacact atggaaggta
    15481 ttcagctttg ggtctacagc aaagacggca caaagaagtt tgtagtcatt gatccggtta
    15541 atattgacaa agagggcaaa actcttactg ttaacttaaa cgatggagat ttcttcatgg
    15601 taatcgcaga tgcgaaataa tcaataattc ggaatcagaa cgcagtcgcc agagatggcg
    15661 gctgtttttt tgtagaaata tgttgcattt ttttattgac gtagttataa taaaacacga
    15721 cgtaaatct
//
