LOCUS       c00042_gnlPro..        14751 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JPGIKCND_42.
ACCESSION   c00042_gnlPro..
VERSION     c00042_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 23:09:13
            Original ID  :: gnl|Prokka|JPGIKCND_42
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14751
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14751
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6477:10722](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6478..10722
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14751
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14751
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(2..1204)
                     /locus_tag="ctg42_1"
                     /transl_table=11
                     /translation="MQLTGAEIIVECLKEQGVDTVFGYPGGAILNVYDALYEYKDQITH
                     VLTSHEQGASHAADGYARATGKVGVCLATSGPGATNLVTGIATAYMDSVPMVAITCNVG
                     TPLLGKDSFQEVDITGIVMPITKHSFIVKDITTLADTVRRAFYIAKSGRPGPVLVDVTK
                     DVTGAKYEYTACAPAEITPKTDTIKDEDIATAVQMIKEAKRPFIFTGGGTIISEASREV
                     TELAHRIDAPVCDSLMGKGGFSGEDPLYTGMLGMHGTKTSNLGVSGCDLLIVLGARFSD
                     RVTGNTKTFAKNAKILQIDVDAAEINKNIVVDASVVGDEKEVLKRILAEVPEMRHSEWT
                     AHISELKEKYPLRYDHSQLTGPYIIEKLYELTKGDAIITTEVGLRGRNQGCSGGNGKIF
                     SK"
     CDS             complement(1280..2953)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ILVD_EDD"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_2"
                     /sec_met_domain="ILVD_EDD (E-value: 6.1e-230, bitscore:
                     753.5, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSDAVKTGTQQAPHRSLFNALGMTKEEMDRPLVGIVSSYNEIVP
                     GHMNLDKITQAVKLGVAMAGGTPVMFPAIAVCDGIAMGHVGMKYSLVTRDLIADSTEAM
                     AMAHQFDALVMIPNCDKNVPGLLMAAARLNVPTVFVSGGPMLAGHLNGHKTSLSSMFEA
                     VGAYAAGKLDEDGLTECEMKTCPTCGSCSGMYTANSMNCLTEVLGMGLKGNGTIPAVYS
                     ERIRLAKHAGMQVMEMYRKNIRPRDIMTKEAILNALTVDMALGCSTNSMLHLPAIAHEI
                     GMDFDISFANEISAKTPNLCHLAPAGPTYIEDLNEAGGVYAVMNELNKKGLLHTECMTV
                     TGKTVGENIKDCVNLNPEVIRPIDNPYSQTGGLAVLKGNLAPDGGVVKRSAVVEEMMVH
                     EGPARVFDCEEDAIAAIKGGKIVEGDVVVIRYEGPKGGPGMREMLNPTSAIAGMGLGSS
                     VALITDGRFSGASRGASIGHVSPEAAVGGPIALVEEGDIISINIPELKLEIKVSDEEMQ
                     ARKAKWQPREPKVTTGYLARYAAMVTSGNRGAILEVPKAK"
     CDS             complement(3061..4143)
                     /locus_tag="ctg42_3"
                     /transl_table=11
                     /translation="MDYKIALIPGDGIGPEIVREAKKVLDKVCEKYGHSFSYSEVLLGG
                     ASIDVHGVPLTDEAIATAKSSDAVLMGSIGGDAKTSPWYKLEPSKRPEAGLLAIRKALN
                     LFANLRPAYLYNELRKACPLRDEIIGDGFDMIIVRELTGGLYFGERQTIEENGVKKAID
                     TLSYNENEIRRIAIKAFEIARKRRNKVTSVDKANVLDSSRLWRKVVEEVAKDYPDVTLE
                     HMLVDNCAMQLVRDPKQFDVILTENMFGDILSDEASMVTGSIGMLSSASLNETKFGLYE
                     PSHGSAPDIAGQDKANPIATILSAAMMLRFSLDMDKEADAVEAAVQKVLTEGYRTGDIM
                     SEGCKLVGTKEMGDLIAAAL"
     CDS             complement(4332..4631)
                     /locus_tag="ctg42_4"
                     /transl_table=11
                     /translation="MNASSGMGMVGAIVWMVVLFGIMYFLMLRPQKKEQKRLQAMLNDM
                     EVGDSIVTTGGFYGVVIDMTEEDVIVEFGNNKNCRIPMRKQAIAEVEKAGSAAE"
     CDS             complement(4880..6031)
                     /locus_tag="ctg42_5"
                     /transl_table=11
                     /translation="MAEYKLLKTEGRAKRAEFHTVHGTIQTPVFMNVGTIGAIKGAVST
                     MDLQQIGTQVELSNTYHLHVRPGDKIVKQLGGLHKFMVWDKPILTDSGGFQVFSLAKLR
                     KIKEEGVYFNSHIDGHKIFMGPEESMQIQSNLASTIAMAFDECPSSVADRDYVQKSVDR
                     TTRWLARCKAEMARLNSLPDTINKEQLLFGINQGAVYEDIRIEHAKAISEMDLDGYAVG
                     GLAVGETHEEMYRILDAVVPYLPQNKPTYLMGVGTPANILEGVERGIDFFDCVYPSRNG
                     RHGHVYTNHGKMNLFNAKYELDTRPIEEGCQCPACQHYSRAYIRHLLKAKEMLGMRLCV
                     LHNLYFYNHMMEEIRDALDAGNFAEYKKMRLEGFEEGKINSKR"
     CDS             6478..10722
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_6"
                     /sec_met_domain="HGD-D (E-value: 7.4e-64, bitscore: 205.8,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 4.2e-38, bitscore:
                     120.7, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYKTLGIDIGSTTVKIAILDENENLIFADYKRHFANIQETLADL
                     LQEAFDQYGEMTLHPVITGSGGLTLANHLGVPFTQEVIAVSTSLQKLAPKTDVAIELGG
                     EDAKIIYFENGNVEQRMNGICAGGTGSFIDQMASLLQTDATGLNEYAKDYKALYPIAAR
                     CGVFAKTDIQPLINDGATKPDLSASIFQAVVNQTISGLACGKPIRGHVAFLGGPLHFLS
                     ELRESFIRTLKLDEEHTIIPENSHLFAAIGSALNAKEDNSISLTEMKDRLRNSIKLDFE
                     VERMEPLFASQEEYDAFAKRQSSYKVKTGDLATYKGNCYLGIDAGSTTTKTALVGEDGT
                     LLYSFYSSNNGNPLKTTIRSIKEIYELLPKDAKIAYSCSTGYGEALLKAALLLDEGEVE
                     TVSHYYAAAFFDPEVDCILDIGGQDMKCIKIRNKTVDSVQLNEACSSGCGSFIETFAKS
                     LNYTVQDFAKAAVFAQHPIDLGTRCTVFMNSKVKQAQKEGAEVSDISAGLAYSVIKNAL
                     YKVIKVSDASELGKHIVVQGGTFYNDAVLRSFEKIAGCEAIRPDIAGIMGAFGAALIAR
                     ERHQEGAETTMLSIDKINELKYTTSMANCRGCTNNCRLTINKFSGGRQYVSGNRCERGI
                     GKEKNKDHIPNLYEYKYKRIFSYTPLTADKATRGKVGIPRVLNMFENYPFWYTFFTELK
                     YEVVLSPTSTRKIYELGIESIPSESECYPAKLAHGHVTWLIRNGVKFIFYPCIPYERNE
                     FPDAVNHYNCPIVTSYAENIKNNVDELNDPSITFRNPFLAFTSEEILANRLVEEFKDIP
                     AEEVKAAVHKGWEEMAAARRDVQKKGEETLKYLEDTGRHGIVLAGRPYHIDPEIHHGIP
                     DLINSYGIAVLTEDSISHLAPVERPIRVNDQWMYHSRLYAAANYVKTRDDLDLIQLNSF
                     GCGLDAVTTDEVYEILDGSDKIYTCLKIDEVNNLGAARIRIRSLIAAIRAKKAQGQKRT
                     VKPASIDKVSFTKEMRKDYTILCPQMSPFHFSLLQAAFNSCGYNLEVLPNDNKHAVDVG
                     LKYVNNDACYPSLIVVGQIMDALLSGKYDLNKTAVVMSQTGGGCRASNYIAFIRRALKK
                     AGMEQIPVISVNLSGLESNPGFKLTLPLVKKVAYGAVFGDILMKCVYRMRPYELEEGIV
                     NRKHKIWEQRVISFLSGSSISHSQFKKMCREMVHEFDTIPISDVKKPRVGIVGEILVKF
                     LPAANNHLAELLESEGAEAVVPDLIDFMCYCFYNQNFKVENLGFKKSKATMANWGIKAI
                     EWVRKPASEALAQSRHFAPPADIRNLAKMASPIVSTGNQTGEGWFLTGEMMELIHGDVP
                     NIVCIQPFGCLPNHIVGKGVIKEIRREYPTANIVAIDYDPGASEVNQLNRIKLMLSTAQ
                     KNLKKAEEKMHK"
     CDS             complement(10961..12589)
                     /locus_tag="ctg42_7"
                     /transl_table=11
                     /translation="MNQKNNLVKNASFLMIAAMISKVIGLLYKSPLSNIIGSLGMGYTS
                     LAQNAYMILLMIASFSIPQAVSKLISERIALKDYRNAHKFFKGAMIYAMVIGGVVGLFC
                     LFGAGLIIPQNQKDAIPALQILAPTIFLSGILGVFRGYFQAYRNMMPTSISQIIEQVFN
                     AAVSLLAAWGFINAFSDGTENSIAKWGAAGSTVGTGAGVVTALAFMLLVYGVNRRKILH
                     RVEKDHRHQEESYKEIFRVIILVVSPIILSAFVYNVNAYINGYLFSDILGRRGGDAAQI
                     GILYAEYATYFMTIINIPLTLSSTAPTSMIPEVSALYATGDIEATRECIDQTVQLSMVV
                     SAPCAMGLAVLAQPIVFLLYGNSTGLAANLLILGSFSILLNGMSNISNGVLQAIGQQRI
                     PVITAAIALVVDIVVVVVLLFTTNLGVYALLIAMVIYSVVVCVLNDRAMKKYLQYKNPW
                     KEGYLYPVLASVPMGIVAGCICYGLNIFVKSNFICLIVSIPVAAVVYLFAYLIISKPSE
                     SQLRRIPGGSYLIRIAEKLPFWQNN"
     CDS             complement(12645..13319)
                     /locus_tag="ctg42_8"
                     /transl_table=11
                     /translation="MSAISGDWLEALKGEFHQPYYAKLYKTVMTEYQTRKIFPPADDLF
                     NAFHFTPLNEVKVVILGQDPYHNDGQAHGLCFSVKRGVETPPSLVNIYQELHDDCGCYI
                     PNNGYLEKWAKQGVLLLNTVLTVRAHQANSHRGIGWEQFTDAAIQVLNEQDRPIVFLLW
                     GRPAQMKKSMLNNPKHLILEAPHPSPLSAYRGFFGCKHFSKTNEFLVANGLEPIDWQIE
                     NI"
     CDS             complement(13352..14110)
                     /locus_tag="ctg42_9"
                     /transl_table=11
                     /translation="MFTKRIIPCLDVNNGRVVKGVNFVQLRDAGDPVEIAKAYDAAGAD
                     ELVFLDITASCEQRDTVVDMVRRVAANVFIPFTVGGGIRTVDDFKKLLREGADKISVNS
                     AAIDRPELISEAADKFGSQCVVVAIDAKRREDGGWNIYKHGGRLDTGIDAIEWAKKVEA
                     LGAGEILLTSMDCDGTKAGYDLALTRAIADAVSIPVIASGGAGTLEHFYDALTEGGADA
                     ALAASLFHYKELEISQVKDYLSDRGISVRR"
     CDS             complement(14112..14750)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_10"
                     /sec_met_domain="GATase (E-value: 4.8e-32, bitscore: 100.7,
                     seeds: 97, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAIIDYYAGNIKSVEKALHYLGEETTVTRDPHTLLNADKVILPG
                     VGSFGRAMENLHTYGLVPVIHEIVEKKTPFLGICLGLQLLFESSEETPGVEGLGILKGK
                     IVKIPPAPGLKIPHMGWNSLHFQNNGRLFQGIPEQTYVYFVHSYYLQAEEPEIVKATTE
                     YSTCIHASVEKDNVFACQFHPEKSSKWGLKILENFAAVGKDGNTEKEGK"
ORIGIN
        1 ctttggagaa aattttccca tttccgccag agcatccctg atttcttcct ctgagtccaa
       61 cctctgtagt gatgatggca tctccttttg tcagttcgta cagcttctca ataatgtatg
      121 ggcctgtaag ctgggaatga tcatatctta acggatattt ttccttcagt tcactgatat
      181 gtgcagtcca ttccgaatgt ctcatttccg gaacctctgc cagaatacgt ttgagaactt
      241 ctttctcatc tcctactacg cttgcatcta ctacgatgtt tttgttaatc tctgcagcat
      301 ctacgtcaat ctggagaatc ttcgcattct ttgcaaaggt ctttgtgttt cctgtgacac
      361 gatcactgaa tctggctcct agcacgatca ggagatcgca gcctgagaca ccaagattgg
      421 aagttttggt cccatgcatt ccaagcattc ctgtgtacag aggatcttct ccggaaaatc
      481 ctcccttacc cataagactg tcacatacag gagcgtcgat tctgtgagca agttctgtca
      541 cttctctgga tgcctctgag ataatcgtac cgccgcctgt aaaaataaat ggtctcttcg
      601 cttctttaat catctgtact gcagttgcaa tgtcttcgtc tttgatggtg tctgttttcg
      661 gtgtgatctc agcaggagcg caggcagtat attcatattt cgcacctgtc acatccttgg
      721 tcacatctac aagcacagga ccaggacgtc cgctctttgc aatatagaat gctctgcgta
      781 cagtgtctgc cagagtagta atgtctttta cgataaagct gtgctttgta ataggcatta
      841 caattcctgt aatatcaacc tcctggaaag aatcctttcc gagcagcggt gttcccacgt
      901 tacatgtgat tgccaccatt ggtacagaat ccatatatgc ggtagcgatt cctgttacca
      961 gattggtagc tccgggaccg gaagttgcaa gacacacacc gactttaccg gttgctcttg
     1021 cgtatccgtc tgctgcatgg gatgctccct gctcatgaga agtcagtaca tgtgtgatct
     1081 ggtctttata ttcatagagg gcgtcatata cattcaggat ggcaccgccc ggatatccga
     1141 atacagtgtc aacgccctgt tcttttaaac attcaacgat gatttcagca cctgtaagct
     1201 gcatctttac gtatcctcct aacttttcag gcaggaatca caggttatgc tgcaattccc
     1261 gccgggtact tgttcatctt tattttgctt ttggtacctc aaggatcgct cctctgtttc
     1321 cggaggttac catggcagca tatcttgcaa gatatcctgt tgttaccttt ggctcacgag
     1381 gctgccattt tgcttttctt gcctgcattt cttcatcgga aaccttgatc tccagtttca
     1441 gttccggaat gttaatactg atgatatccc cttcttcaac aagtgcgatc ggtccgccga
     1501 ctgctgcttc cggtgatacg tgtccgatgg atgctcctct ggatgcaccg ctgaaacgtc
     1561 cgtctgtgat cagggctaca gaagatccca gtcccatacc tgcgatcgca gatgtagggt
     1621 tcagcatctc tctcatacca ggaccgcctt tcggtccttc ataacggata acaactacat
     1681 caccctcaac gatcttgcca cctttgatag ctgcgattgc gtcttcctcg cagtcaaaga
     1741 ctcttgcagg tccttcatgg accatcatct cttctacaac tgcagaacgt tttacaacac
     1801 caccgtccgg tgcaaggtta cccttgagaa ctgcaagtcc gcctgtctgg ctgtatggat
     1861 tgtcaatcgg tctgataact tcaggattta agtttacaca atctttgatg ttctcgccta
     1921 ctgtcttgcc tgtaactgtc atgcactcag tatgaagaag tcccttctta ttcagttcgt
     1981 tcataactgc gtatacaccg cctgcttcgt tcaggtcttc tatgtatgta ggacctgcag
     2041 gtgcaaggtg acagaggttt ggagtctttg cgctaatttc gtttgcaaag ctgatatcaa
     2101 agtccattcc gatctcatga gcgatagccg gaaggtgaag catactgttt gtggagcatc
     2161 caagtgccat gtctactgtc agggcattga ggattgcttc ctttgtcatg atatctcttg
     2221 gacggatgtt ctttctgtac atttccataa cctgcatacc tgcatgtttt gcaagacgga
     2281 tacgttcgga atatacagca ggaatagttc cgtttccttt cagtcccata ccaagaacct
     2341 ctgtcagaca gttcatggag tttgctgtgt acataccgga acaggatccg catgtaggac
     2401 atgttttcat ttcacattct gtcaggccgt cctcatcaag cttgcctgct gcgtaagcac
     2461 ctactgcctc gaacatactg gaaagacttg tcttgtgtcc gttcagatgt ccggcaagca
     2521 ttgggccgcc gcttacaaat acagtaggaa cattcagtct ggctgctgcc atcagaagtc
     2581 cgggtacgtt cttgtcacag tttggaatca taaccagtgc atcaaactga tgtgccattg
     2641 ccatggcttc tgtggaatct gcgatcaggt ctctggtaac cagagaatat ttcattccaa
     2701 cgtgtcccat tgcaataccg tcgcagactg cgattgccgg gaacataaca ggtgtaccgc
     2761 ctgccattgc cacaccaagc ttaactgcct gtgtgatctt gtcaaggttc atatgacccg
     2821 gtacaatttc attgtaagaa cttacgatac ctaccagagg tctgtccatt tcttcttttg
     2881 tcattccaag agcattaaac agggaacggt gaggtgcctg ctgtgtgcct gtttttactg
     2941 catcacttct cattgtttta tttcctcttt tcttactgtt ttatttattt ttaatgattc
     3001 aaccgaaatt cctgactccg taatctgcct gcgccggctg aatcctctta atatcaattc
     3061 ttacagagct gctgcgatca gatcgcccat ttcctttgtt cctacaagct tgcatccctc
     3121 tgacatgata tcacctgtgc ggtatccctc tgtcagaact ttctgcactg ctgcttccac
     3181 tgcatctgct tccttgtcca tatcaaggga gaagcgaagc atcattgctg cggaaaggat
     3241 agttgcgata gggtttgcct tatcctgtcc tgcaatatca ggtgcagaac catggcttgg
     3301 ctcatagaga ccgaattttg tctcatttaa acttgcagat gaaagcattc cgatggaacc
     3361 tgttaccata cttgcctcat ctgaaaggat atctccgaac atgttctctg taaggataac
     3421 atcgaactgt tttggatcac gtacaagctg cattgcgcag ttgtcaacca gcatatgctc
     3481 taaggtaaca tccggatagt ctttggcaac ttcctctacc acttttctcc agagtctgga
     3541 agaatccaga acatttgcct tatctacgct tgttacttta tttcttctct tacgtgcgat
     3601 ctcaaatgct ttgatggcaa tacggcggat ttcgttttca ttataggaaa gtgtatcaat
     3661 cgctttcttc acaccattct cttcaatagt ctgacgttct ccgaaataca ggccacctgt
     3721 aagctcacgt acaatgatca tgtcaaatcc gtctccgatg atctcatcgc ggagagggca
     3781 ggcttttctc agctcattgt aaaggtaagc cggtcttaag tttgcaaaaa gatttaatgc
     3841 cttacggatt gcaagaagtc ctgcttccgg gcgtttggac ggctcaagct tataccatgg
     3901 agaagttttt gcatctccgc caatagagcc catcagtacg gcgtctgatg atttggcagt
     3961 ggcaattgcc tcatcagtaa ggggtacgcc gtgtacatcg atggatgcgc cgcctaacag
     4021 aacttctgaa taggaaaagc tgtgtccata tttctcgcat accttgtcca gtactttctt
     4081 tgcttctctt acgatttccg gtccgattcc gtcgccgggg atcaatgcaa tcttataatc
     4141 cataataatt tcctccaaaa atactctaat tgcgtaattg ttattataat aacgcacttt
     4201 ccgacagatt tcaacctatt aaagtgaaaa aatacaaaag tgctgttttc cagagatttt
     4261 actgtaaaaa taaaaaaaca gaaccacagc catcactgac tataggttcc gcttttttca
     4321 tatctctttc attattcggc agcgcttccg gctttctcaa cttcagcgat tgcctgtttt
     4381 ctcattggaa tacggcagtt tttgttatta ccgaattcta cgatcacgtc ttcttctgtc
     4441 atatcaatga caactccata aaagccgccg gtagtaacaa tgctgtcgcc aacttccatg
     4501 tcatttaaca ttgcctgaag tctcttctgc tcttttttct gagggcgaag cattaagaag
     4561 tacataattc cgaacagtac taccatccag acaatagcgc caaccatacc cattccgctt
     4621 gatgcgttca ttttgattcc tcctgtaact tttcctgtta ttctgcatat ttgcagtcca
     4681 tcatgtattc acagaccgtc ctgacggctg ctcatactga agagctgctt tgcgatccac
     4741 ttataatctc cgttaccttc tgtatgaaat cttgttttca tgcagaacaa tctgattaaa
     4801 gcgtcactac acatcataca caaaaaaacg ctttacttca agagtttttg gcatatttaa
     4861 taattatttt atatacagat tatcttttcg agtttatttt gccctcttca aagccttcca
     4921 gccgcatttt cttatattct gcgaagtttc ctgcatcaag agcatcacgg atctcttcca
     4981 tcatatgatt atagaaatac agattgtgaa gtacacagag acgcattccc agcatttcct
     5041 ttgctttcag aagatgacgg atataggctc tgctgtaatg ctggcatgca ggacactggc
     5101 agccttcttc gataggacgt gtgtccagtt catattttgc attgaacaga ttcatctttc
     5161 catgattggt atatacatgt ccatggcggc cgttacggct tggatatacg cagtcaaaga
     5221 aatcaattcc acgttcaaca ccttccagga tatttgccgg tgttcccacg cccatcaggt
     5281 aagtaggttt gttctgagga agataaggga ctaccgcatc caggatcctg tacatctctt
     5341 catgggtttc tccaactgcc agaccgccga cagcatagcc atccagatcc atttcagaga
     5401 tcgctttggc atgctcaatg cggatatctt cataaacagc accctggttg attccaaaca
     5461 gaagctgttc tttgttaatg gtatccggca gactgttcag tctcgccatt tccgctttac
     5521 agcgggcaag ccatcttgtg gtcctgtcta cagatttctg cacataatcc ctgtcagcca
     5581 cactgctggg acattcatca aatgccatgg caatggtgga ggcaagattg gattggatct
     5641 gcatactctc ttccggtccc ataaagatct tatgcccgtc aatatgggaa ttaaaataaa
     5701 ccccctcttc tttgatcttt ctcagctttg caagggaaaa tacctggaat ccgcctgagt
     5761 ctgtaaggat tggtttgtcc cataccataa atttatgaag gccgcctaac tgctttacta
     5821 ttttatcacc cggacgcaca tgaagatgat aagtatttga taattctacc tgtgttccga
     5881 tctgctgtaa atccatggtg gatacagcgc ctttaatcgc accgatcgtt cccacattca
     5941 taaaaacagg agtctggatc gtaccatgca ctgtatgaaa ctctgcacgc ttggcacggc
     6001 cttctgtttt aagaagttta tattctgcca ttttttctct cctcttgata aaaatcactt
     6061 tttctattat atcccgaaat agctgaattt tcaactgcaa ataaggtaat cattggtaaa
     6121 ctttcatatt gtcttttcca gaccattagc gtataatatt acggaatatt ccatatctgg
     6181 aaacagatat ttaataggaa agaacaggat agatttttac tgtttacttc gtgtccggca
     6241 acacgctttg catgatatca gcagcaaaca gtaaggaaaa tgttactgtt cactccgttc
     6301 tcagtaacgt agccaaaatt cattccagat tgcctgtggc aatggaattt tggcttgtat
     6361 gtctcgggat tttggcatat tcatgccaaa acacctcgcg ggatagtggt gtgtgaacag
     6421 taacaggaaa atttcaattt tgtttatata caatacgagg aggcttgaat ttactttatg
     6481 aattacaaaa cacttggaat tgacattggt tccactactg taaagatcgc gatcttagat
     6541 gagaatgaaa atctcatttt cgcggattac aagcgtcatt ttgcgaacat tcaggaaacc
     6601 cttgcagacc ttcttcagga ggcctttgac cagtatggcg agatgactct ccatcctgtg
     6661 atcacaggtt ccggcggtct gacccttgcc aaccatctgg gcgttccttt tacccaggag
     6721 gttattgcag tttctacttc tctgcagaag ctggcaccta agacagatgt tgccatcgag
     6781 cttggcggtg aggatgccaa gatcatttat ttcgaaaacg gaaacgtaga acagcgtatg
     6841 aacggtatct gtgcaggtgg caccggttct ttcatcgacc agatggcttc tcttctccag
     6901 acagatgcca caggtctgaa tgaatatgcc aaagattaca aagcgctcta cccgattgct
     6961 gcacgctgcg gtgttttcgc caaaacggat atccagccgc tgatcaatga cggtgcaacc
     7021 aaaccggatc tgtcagcttc tattttccag gcagttgtaa accagaccat ctccggtctt
     7081 gcctgcggaa aacccatccg tggacatgtt gcattcctgg gtggtccgct tcacttcctg
     7141 tccgaactga gagaatcctt tatccgtact ttgaagctgg atgaggaaca caccatcatt
     7201 ccggagaact cccatctttt tgcagccatc ggttctgcat taaatgcaaa agaagacaac
     7261 tccatttccc tgacagaaat gaaagacaga ctccgcaatt ccattaagct ggattttgaa
     7321 gtagaacgta tggaaccact tttcgcttct caggaagaat acgatgcatt tgcaaaacgt
     7381 cagagttcct acaaagtaaa aacaggagat ctggctacat ataaaggaaa ctgctatctg
     7441 ggtattgatg caggttccac cacaaccaaa actgcactgg taggcgaaga tggaacactt
     7501 ctctattcct tttacagtag caacaacgga aacccgttaa aaactaccat ccgttctatt
     7561 aaagaaatct atgaactgct tcccaaagac gcaaagatcg cttattcctg ttctacaggt
     7621 tacggcgagg ctctgctcaa agcggccctg ctcctggatg agggcgaggt tgagaccgta
     7681 tcccattact atgcagctgc attctttgac ccagaggtag actgtatcct ggatatcggc
     7741 ggacaggata tgaaatgtat caagatccgc aacaagaccg ttgacagcgt acagttaaat
     7801 gaagcatgct cctccggatg cggttccttt attgaaacct ttgccaaatc cctgaattat
     7861 acagtacagg atttcgcaaa agctgctgtt tttgcacagc atcctataga tcttggtacc
     7921 agatgtactg ttttcatgaa ttccaaggta aagcaggcgc agaaagaggg agctgaggtt
     7981 tccgatattt ccgcaggtct tgcttactct gttatcaaaa atgctctgta taaggttatc
     8041 aaggtttctg acgcttccga acttggcaag cacatcgttg tacagggtgg taccttctac
     8101 aatgatgcgg ttcttcgaag cttcgaaaag attgcaggct gcgaagccat ccgtccggat
     8161 atcgccggaa tcatgggtgc cttcggtgct gcactgattg cccgtgaacg ccatcaggaa
     8221 ggcgcagaaa cgactatgct ctccattgat aagatcaacg agctgaaata tacaacttct
     8281 atggcaaact gtcgtggatg taccaataac tgccgtctga ctatcaacaa attctccggc
     8341 ggccgccagt atgtaagcgg taaccgctgt gaacgcggta tcggtaagga aaagaacaaa
     8401 gatcatattc cgaatcttta tgaatacaaa tataaacgta ttttctccta cacaccgctt
     8461 actgctgata aggcaacgcg aggtaaagta ggtatcccgc gtgttctgaa tatgtttgag
     8521 aattatcctt tctggtatac tttctttaca gaactgaagt atgaggttgt gctctctcct
     8581 acttccacca gaaagattta tgagttgggt attgaatcca ttccaagtga atccgaatgc
     8641 taccctgcca agctcgcaca tggccatgta acctggctga tccgcaatgg tgtgaaattt
     8701 attttctacc cttgtattcc atatgaacgt aacgagttcc cggatgcagt caatcactat
     8761 aactgcccga tcgttacctc ttatgccgaa aatatcaaaa ataacgtaga cgaattaaat
     8821 gatccgtcca ttaccttccg caatccgttc cttgcattta cttctgagga aattctggca
     8881 aatcgtctgg tagaggaatt taaggatatc ccggcagaag aagtcaaagc tgctgtgcat
     8941 aagggctggg aggaaatggc tgctgcacgc cgcgatgtac agaaaaaagg ggaagaaacc
     9001 ctgaaatatc tggaagatac aggacgccat ggtattgtcc ttgcaggacg cccataccat
     9061 attgacccgg aaatccatca tggtatcccg gatctgatca acagctatgg tattgccgta
     9121 cttaccgagg attccatctc tcatctggca cctgtggaac gcccgatccg cgttaatgac
     9181 cagtggatgt accactccag actgtatgct gctgcaaact atgtaaagac acgcgatgac
     9241 ctggatctga tccagctcaa ctcttttgga tgtggtctgg atgcagttac tactgacgag
     9301 gtttatgaaa tccttgacgg aagtgacaaa atctatacct gcttaaagat tgacgaggta
     9361 aataaccttg gtgctgcaag aatccgtatc cgttccctga tcgcagcgat ccgtgcgaag
     9421 aaggcacagg gacagaaacg tactgtcaaa cctgcttcta ttgataaagt atcctttaca
     9481 aaggaaatga gaaaggacta taccatcctc tgcccgcaga tgtcaccgtt ccatttcagc
     9541 ctcctgcagg cagcattcaa ttcctgcgga tacaacctgg aggtgcttcc gaatgacaat
     9601 aagcatgcag tggatgttgg tctgaagtat gtaaacaatg acgcctgcta tccgtctctg
     9661 atcgttgtgg gacagatcat ggatgctctg ctttccggta aatatgacct gaacaaaacg
     9721 gccgttgtca tgtcacagac aggtggcgga tgtcgtgctt ccaactatat tgcatttata
     9781 cgacgcgcat taaagaaagc cggtatggaa cagattccgg ttatctctgt taacttaagc
     9841 ggtctggaaa gcaatcccgg attcaaactt acgcttccat tagtgaagaa agttgcttat
     9901 ggtgccgtat tcggagatat cctgatgaaa tgcgtatatc gtatgcgtcc ttatgaactg
     9961 gaagagggaa tcgtaaacag gaaacataaa atctgggaac agcgtgtgat ctctttctta
    10021 agcggaagca gtatcagcca cagccagttt aagaaaatgt gccgcgaaat ggttcacgaa
    10081 tttgatacca ttccgatcag tgatgtgaaa aagcctcgtg tcggcatcgt aggtgagatc
    10141 cttgtcaagt tcctgcctgc tgcaaataat catctggcag agcttctgga atctgaaggc
    10201 gctgaggcag ttgtaccgga tctgatcgat ttcatgtgct actgcttcta taatcagaac
    10261 ttcaaggtag aaaatcttgg attcaagaag tccaaggcaa ccatggcaaa ctggggaatc
    10321 aaagcaatcg aatgggtgag aaagcctgca agcgaagctc ttgcacagag ccgccatttt
    10381 gcaccgcctg ctgatatcag aaatctggca aaaatggcat ctccgatcgt ttccaccgga
    10441 aaccagacag gtgagggatg gttcctgaca ggtgagatga tggaactgat ccatggagat
    10501 gttccgaata ttgtttgtat ccagcctttc ggatgtctgc cgaaccacat tgtaggtaag
    10561 ggtgttatca aagagatccg cagagaatat ccgacagcca atattgtagc catcgactat
    10621 gatccgggtg caagtgaagt taaccagctc aaccgaatca aactgatgct ctccacagct
    10681 cagaaaaacc tgaaaaaagc agaagaaaaa atgcataaat aataccgtaa tggatatatt
    10741 gcaatgtatt ttaccttgca atatatccgc cttagagcgt atttgaaaaa tcattcccgc
    10801 aatctacata tcctgctttg cgaaaagcat ttttcaaacg cgctcaaaaa agagttatat
    10861 ttcagaaatt ttaaatgtgt ttctatttca gaaatacatt taaaccatga aatataactc
    10921 ttttattttt tataacttct gtttttataa cttctgtttt ttaattattc tgccagaacg
    10981 gaagtttctc tgcaatcctt atcagatagc ttccacccgg aattcttcta agctgtgatt
    11041 ctgacggctt gctgatgatc aggtaagcaa acagataaac aaccgcagca acaggaatgg
    11101 aaacgatcag acaaatgaaa ttggatttta caaaaatgtt cagtccatag cagatacagc
    11161 ctgcaacaat tcccatggga acagatgcaa gaacaggata cagatatcct tctttccatg
    11221 gattcttata ctgcagatat ttcttcatgg ctctgtcatt taacacacat acaaccacag
    11281 aatagatcac cattgcgatc agcagtgcat aaactccaag gtttgtagta aacagcagca
    11341 ctaccactac cacaatatcc acaaccagtg cgattgcagc cgtaatcacc ggaatcctct
    11401 gctgtccgat tgcctgcaga actccattgg aaatatttga cattccattg agcaggatcg
    11461 aaaaagaacc aaggatcagc aggttggctg ccagtcctgt ggaatttccg taaagcaaaa
    11521 atacaatcgg ctgtgcaagc actgccagtc ccatggcaca tggggcagaa actaccatag
    11581 aaagctgtac ggtctggtca atgcactctc tggtcgcttc aatgtctccg gtggcataca
    11641 gggcggaaac ctccggaatc atggaagtag gtgccgtact ggacagcgtc agaggaatat
    11701 taataattgt cataaagtaa gtagcatact ctgcatataa aataccaatc tgtgccgcat
    11761 ctccacctct tcttcccaga atatccgaga aaagataccc attgatataa gcatttacat
    11821 tataaacaaa ggcgctgaga atgatcggcg aaacaaccag gataatcaca cgaaaaatct
    11881 ctttgtagga ctcttcctga tgtctgtggt ccttctctac ccggtgcagg atttttctgc
    11941 ggttcacacc atataccaga agcatgaatg ccaatgcagt caccactccg gctccggttc
    12001 ctactgtgga acctgctgcc ccccattttg caatgctgtt ctctgttcca tctgagaatg
    12061 cattgatgaa tccccaggct gccagaagac tgactgccgc attaaatacc tgctcaatga
    12121 tctgggagat agatgttggc atcatatttc tgtatgcctg aaaatatcct ctgaataccc
    12181 caagaatacc ggacaaaaaa atcgtcggag ccaggatctg aagtgccgga attgcatcct
    12241 tctgattctg agggatgatc agccctgctc caaagagaca gaataaaccg accactccgc
    12301 caatcaccat ggcatagatc atggcaccct taaagaactt atgtgcattt ctgtaatcct
    12361 tcagagcaat acgctcggag atcagcttgg ataccgcctg tggaatacta aaggatgcga
    12421 tcatcagaag gatcatatag gcattctgtg caagacttgt atagcccatt ccaaggcttc
    12481 cgataatatt ggaaagggga ctcttgtaca gaagaccgat caccttggag atcatagctg
    12541 caatcatcag aaaggatgca ttttttacta aattgttttt ctgattcatg ttatcactgt
    12601 gtgtctttta cctgactaca cattacctct tttcttatat attcttatat attttctatc
    12661 tgccagtcga ttggttccag accattggca acaagaaatt cgtttgtttt actgaaatgt
    12721 ttacatccga aaaatcccct gtaagcagac agaggacttg gatgaggtgc ctccagaatc
    12781 agatgcttcg gattattcag catggatttt ttcatctgcg ccggacgtcc ccatagcaga
    12841 aatacaatag gacggtcctg ctcattcaga acctggatcg cagcatccgt aaactgctcc
    12901 cagccgatcc ccctgtgtga atttgcctga tgagcgcgta cagtcagaac tgtgttcaga
    12961 agaagcactc cctgcttcgc ccacttctcc agatagccgt tattggggat atagcatcca
    13021 cagtcatcat gaagctcctg ataaatattc accagggacg gtggcgtctc cactcctctc
    13081 tttacggaaa aacaaagccc atgagcctgc ccgtcattat gatagggatc ctgacccaga
    13141 atcactacct tcacttcatt caacggtgta aaatgaaatg cattaaacag atcatccgca
    13201 ggaggaaaaa tcttcctggt ctgatattct gtcatcaccg ttttatataa tttcgcataa
    13261 tacggctggt gaaactcccc cttcagggct tccagccagt cacctgaaat tgctgacata
    13321 ccttatcctt cacctcttat atttttcgtg gtcatcgtct gacagaaatt cccctgtcag
    13381 acagataatc cttcacctga gaaatctcca gttctttata atggaacaaa gacgcagcca
    13441 gtgcagcatc tgctccccct tcggtcagtg catcataaaa atgctccagt gtacctgcac
    13501 cgcctgatgc gatcacagga atggagacag catcagcaat tgctctggta agagccagat
    13561 catatcctgc ttttgtaccg tcacagtcca tactggtaag aaggatttcc cctgcaccca
    13621 gagcttccac tttctttgcc cactctatgg catcaatccc tgtatctaat cttccgccat
    13681 gtttgtaaat attccatccg ccgtcttctc tgcgcttggc atcaatagcc acaactacgc
    13741 actggcttcc aaacttgtca gccgcctcac tgatcagttc cggtctgtca attgctgcag
    13801 aatttacgga aatcttatct gctccttctc tcagcagttt cttgaaatca tctacagtac
    13861 ggataccgcc gcctactgta aacgggataa atacattggc agcaacccgt cttaccatgt
    13921 caactaccgt atctctctgt tcgcaggatg ctgtaatatc gagaaacacc agttcatctg
    13981 ctcctgctgc atcataggct ttggcaatct ccaccggatc acccgcatcg cgaagctgca
    14041 caaaatttac gccctttacc acacgtccgt tatttacatc caggcaggga ataattctct
    14101 ttgtaaacat cttattttcc ctccttctca gtattgccgt cttttcccac agcagcaaaa
    14161 ttttcaagta tcttcagtcc ccatttgctg ctcttttccg gatggaactg gcaggcaaat
    14221 acattgtcct tttctacgga agcatgaata caggtgctgt attctgtagt agcctttaca
    14281 atctcaggct cctctgcctg cagataatag gaatgcacaa aatatacata ggtctgttcc
    14341 gggattccct gaaacagtct gccattattc tgaaaatgca gggaattcca tcccatatgt
    14401 ggaatcttaa gccccggcgc aggcggaatc ttaacaattt tccctttcag gattccaagg
    14461 ccttccaccc ccggtgtctc ctcgctgctt tcaaaaagga gctgaagtcc caggcagatt
    14521 ccaagaaatg gcgtcttctt ctctacaatc tcatggatca caggtacaag tccgtatgta
    14581 tgaagattct ccatcgcccg tccaaagctt cccacgcccg gcaggattac tttatccgca
    14641 tttaacaaag tatgcggatc gcgggttact gttgtttctt ccccaagata atgaagtgct
    14701 ttttccacgc ttttgatatt tccagcataa tagtcaatta ttgcaatcat g
//
