LOCUS       c00055_gnlPro..        13545 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JPGIKCND_55.
ACCESSION   c00055_gnlPro..
VERSION     c00055_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 23:09:13
            Original ID  :: gnl|Prokka|JPGIKCND_55
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13545
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13545
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4828:13205]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4829..13205
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13545
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13545
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             239..727
                     /locus_tag="ctg55_1"
                     /transl_table=11
                     /translation="MPKNKFQEVIFTIIMVFVMVYAMICYNIVLNTGTMTNETFLLAFH
                     ELTFMGPIAFILDFFIIGGLAKKIAFGVVDMRRDNPFHLVLAISAVSVAFMCPCMSFAA
                     TVLIKHAPASQIIPTWLQTTAMNFPMAFFWQIFYAGPFVRFIFGKLFPEKEKAAASAE"
     CDS             928..1926
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SBP_bac_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1044:Bacterial extracellular solute-binding protein
                     (Score: 57.1; E-value: 9.5e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg55_2"
                     /sec_met_domain="SBP_bac_1 (E-value: 2e-18, bitscore: 57.1,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKLFAFGLAVVLALMPVQAFGKTVSITNVSYDPTREMFEQYNK
                     IFEDHWKEKTGDDVEVIQSHGGSGKQALEVANGLDADVVTLALEYDIESIENAGLIKAG
                     WKDKFDNDSSPYTSTIVFLVKKGNPRDIKDWDDLTKKGVGVVTPNPKTSGGARWNYMAA
                     WAYADKKYGGDEAQMKEFIKKLYRNVVVLDSGARGATTSFVENGQGDVLVAWENEAYLS
                     MRDYPDEYEIVTPSVSILAQPSVAVVDEVVDYRDTRDVATEYLNYLYSDEAQEIAAENY
                     FRPTNEKILKKHSDTFDLNINLANISDYGGWDKVQEKHFTDGGIFDQIYER"
     CDS             1997..2833
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 83.9; E-value: 4e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg55_3"
                     /sec_met_domain="BPD_transp_1 (E-value: 8.4e-27, bitscore:
                     83.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRNKPVIPGFGLSMGITISILSLVVLIPLASLVVYTAKLSFKD
                     FIETITRARVLASFYTSFVCAFAAAVINGIMGTILAWVLVKYDFPGKRLMDGVIELPFA
                     LPTAVAGIALTSLTSDSGIVGSFFAGFGIKIAYTRIGITVAMIFVGIPFVVRSVQPVLE
                     KMDNSYSEAAGVLGAKKTTIFWKVIFPELKPAIFAGTGLAFGRCLGEYGSVVFIAGNKP
                     YYTEITPLVIMSKLQEFDYSSATAIALVMLAVSFFILFLNSMIQQRNARILRGGNA"
     CDS             2833..3657
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 60; E-value: 8.2e-19)"
                     /gene_kind="transport"
                     /locus_tag="ctg55_4"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.7e-19, bitscore:
                     60.0, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNNEKTSEKITKWLLVGISVLFLAVMLLLPLITVITEALRSGWK
                     VYAAAVTDEYTIKALLLTVKATLFAVVFNTVFGVFAAWALTKFQFRGKKLLTTLIDLPV
                     TISPVIAGLIFLLIFGRQSPVYFFLMKLGIKVVFSVPGIIIATVFVTFPFISRELIPVL
                     EAEGSDEEEAAALMGAGGWTIFWKITFPHIKWALLYGVVLCTARAMGEFGAVSVLSGHL
                     RGKTNTLPLHVEILFNEFQYVPAFAVSSLLVIMAVIILVVRSLIEYKGKKEA"
     CDS             3659..4717
                     /locus_tag="ctg55_5"
                     /transl_table=11
                     /translation="MYVELKNINKTYGSYQASRNVNFGIEKGKLIGLLGPSGSGKTTIL
                     RMIAGLETPDSGEVIIDGKVVNDVPASQRGIGFVFQNYALFRYMTVYDNVAFGLKVQKA
                     DKKKIDARVRELIKLVGLEGLEKRYPSQLSGGQRQRVAFARALAPNPQVLLLDEPFAAI
                     DAKIRQELRSWLKEMIGKLGITSIFVTHDQDEAIEVADEIIITNAGRIEQKGTPIGVYR
                     NPETAFTASFFGQPSVLKNADDFHTFAQAEGADKIIVRPEFVKISKLDEVEKFKTSVSR
                     GVVERVSFRGDNLELQVRVNNSVVTARRSLEKADIREGETVNVFLYRIFALRGDSVQLI
                     ENEAVRDDFVII"
     CDS             4829..6574
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 71.4; E-value:
                     2.7e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg55_6"
                     /sec_met_domain="FAD_binding_2 (E-value: 5.6e-23, bitscore:
                     71.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 9.6e-09,
                     bitscore: 25.2, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTERIRTDVLIIGGGTAGCFAAYVIGKKSGRKVLIAEKANIKRS
                     GCLAAGVNALNAYITEGRVPQDYVDYAKKDAHGIVREDLLLTMSERLNHVTKVMEDLGL
                     VILKDENGKYVARGNRNIKINGENMKPILAKAAAEQENVTVLNHVNITDYKTENKKVTG
                     AVGFSVNEDIFYDIDAKAVLCATGGAAGLYRPNNPGFSRHKMWYPPFNTGAGYAMGLLS
                     GAEMTTFEMRFIALRCKDTIAPTGTIAQGVGARQVNAHGDIYETKYGLTTSQRVYGTVM
                     ENREGNGPCYLRTEGISKEQEQDLYKAYLNMAPSQTLKWMEAGKGPSEENVEIEGTEPY
                     IVGGHTASGYWVDNNRATTIEGLYAAGDVAGGCPQKYVTGALAEGEIAAEAILEYLNGK
                     DDDRIAAENKEEDLERGGKQELSQTAIVKKAEYESHLNASRSLMNAEQLEEAMQKIMDQ
                     YAGGIGTDYRYRGMSLAKADEKIAALLPVVDTLAATDTYELMQIYELRERLIVCQAVIA
                     HLAARKETRWHSFGENTDYPQQSEEWMKYVNSRMENGEIKIVYRDLITKENTGLNTAEK
                     GAGER"
     CDS             6571..6885
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg55_7"
                     /sec_met_domain="Fer4_9 (E-value: 1.7e-13, bitscore: 40.4,
                     seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 2.5e-09, bitscore: 26.9,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.5e-05, bitscore: 14.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIRIQKSKCAGCGRCIEACPGNLIKKDKENKAFIRQVRDCWGCT
                     SCIKECRHDAIRFFLGADVGGRGASMVVSEKPDISTWTVEKPDGTKITIQVNKKDANKY
                     "
     CDS             6916..8034
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAPS_reduct"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg55_8"
                     /sec_met_domain="PAPS_reduct (E-value: 3.9e-65, bitscore:
                     208.9, seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VCLKNALRKMCVTICGRFCSDEGVVVGYDNRIRTKYTAKWGVQIA
                     GMIFQTRSSVFAQVRKDSEYKQTEEDNAMSNLSHLDALEAEAIYIMREVAAECEKPVML
                     YSIGKDSSVMLHLAMKAFYPEKPPFPFLHIDTTWKFHEMIEFRDRIAKENGIDMLVYTN
                     EEGVKAGINPFDNGSAYTDIMKTQALKQALTKYGFTAAFGGGRRDEEKSRAKERIFSFR
                     NSAQAWDPKNQRPEMWKLYNTKIQKGESMRVFPISNWTEKDIWQYIQRENIEIVPLYFA
                     KERPVIYRDGNIIMVDDDRLKLRPGEKIENKKVRFRTLGCYPLTGGIESEADTLDEIID
                     ETLSAVSSERTSRVIDHEAAGSMERRKREGYF"
     CDS             8036..9676
                     /locus_tag="ctg55_9"
                     /transl_table=11
                     /translation="MKGLLKFITCGSVDDGKSTLIGHILYDAKLLYADQEKALELDSKV
                     GSRGGAIDYSLLLDGLMAEREQGITIDVAYRYFTTNNRSFIVADTPGHEEYTRNMAVGA
                     SFADLAVILVDASQGVLVQTRRHARICALMGIRYFVFAVNKMDLIEYDEKRFCDIENQI
                     AALIEELKLANVTIVPVSATEGDNVTTKSDNMPWYKGEALLSHLETVDIKEDTEKGFYM
                     PVQRVCRPNHEFRGFQGQIENGAIRAGDLVTTLPSKEEAHVKSILVGDKEVQEAVQGQP
                     VTIQLDREVDVSRGCVLTIDSGAVLTDSVEADILWMDDNALTDGKNFFVKIGTKMIPGL
                     VTKINYSVDVNTGEKKSAYTLKKNEIASCTLEFSEKIVVDEFDRHRTLGELILIDRVTN
                     MTSACGVVRKTFVSQDRSQIGKVDEQVRAGLKGQTPVVVEFPIGKEGITLDFAEQVEKG
                     LTVLGKHTYLYHPAASENYAETVRHLKAAGLIVLLVLDENTAKDETLKTLDGFYANWQI
                     DGITVKDAIDFVKKKSAFTVQSVHDGNYI"
     CDS             10347..10601
                     /locus_tag="ctg55_10"
                     /transl_table=11
                     /translation="MRLEKVQEALKTKKIHYEYTEENGCGSIDFMFRGLRFHIWEYEDR
                     VWGAETNVFEAGRSQDIEGDYEEIISGEILSWPDMLPGM"
     CDS             10620..11465
                     /locus_tag="ctg55_11"
                     /transl_table=11
                     /translation="MIFTKKYRTGQIVLTACIVAVCMFSNVHGTEAAGPPAPKTLTVTP
                     TEKSKSTAKSASTSKSKSTPKSKSALTQKPEATPIPASTPTPEQEAETDKQNPADQGTL
                     SKPDHPDTISADKLVFIGDSRTEGLRDAVNDDSIWSCLSSMGYDWMVSTGVPQVEDQIE
                     DNTAVIILMGVNDLYHVNDYVSYINSKAAEWGNRGAQTYFVSVGPVQNDPYCSNAEIES
                     FNAAMQANLSGVTYIDVYSHLVSEGFSTVDGTHYPDSVSVDIYNYILDHLEEQRSGIWG
                     "
     CDS             11688..13205
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg55_12"
                     /sec_met_domain="Fer4_7 (E-value: 1.2e-11, bitscore: 35.0,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.4e-11, bitscore: 33.8,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5.5e-06, bitscore: 16.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGLYSSKTEIRHKIFTEIARMAYEGQSPEMLEELPYKIVPGEIA
                     TYRDSIFLERAVVGERLRVAMGMSLRKVTEHAPISKGVEASVIEEKYYEPPLINVIKFA
                     CNSCPEKRVMITEGCQGCLEHPCVEVCPKKAVHMEGGRSHIDEDACIKCGKCLEACPYN
                     AIIKQERPCSKACGMNAIGSDEYGRAEIDQDKCVSCGQCLVSCPFSAIVDKGQIFQTVM
                     ALKSETPVYAIVAPAIAGQFPGMENNKIRGAFQALGFTDVREVAVGADLCTVEEAKDFL
                     EEVPEKLPFMATSCCPSWSMMAKKLFPEQAKCISMALTPMVLTARLIKQKEPNCKIVFV
                     GPCAAKKLEASRKSIRSYVDFVLTFEEVAGMFDAKGVDWKDIPEGEPLFRASADGRGFA
                     VSGGVAEAVVHVVKRIDPDREVKVMNAEGLQNCKKMLQMAKIGKYNGYLLEGMACPGGC
                     VAGAGTIQTVKKAAAALEKMKKEALFTDAYDSKYRARLESLEKFDVE"
     CDS             13144..13269
                     /locus_tag="ctg55_13"
                     /transl_table=11
                     /translation="MPMTPNTEQDWKVWRNLMWSEILTESVKSYMDCKCLNAISI"
ORIGIN
        1 caatctggaa tgaattttgg ctacgttact gtgaacggag tgaacagtaa cgtttcctga
       61 ttcacactgc aggtactgaa aaaatccttg acttttttta aaacagtccg tataataacc
      121 aacggtaaat ttaagaaaca gatatttggt attattggaa acggtacatc ctcctggatg
      181 gttatgaaca acacaaatct ctaattgatg ttattcatac tatctaagga ggatttttat
      241 gcctaaaaac aagtttcagg aagttatttt tacgattatc atggtgtttg taatggtcta
      301 tgccatgatc tgctacaaca ttgtactgaa tacagggaca atgacaaatg agacatttct
      361 gttagctttt catgaattaa cattcatggg accgattgca tttattcttg atttctttat
      421 catcggtggt cttgcaaaga agattgcatt tggtgttgtg gatatgagaa gagataatcc
      481 gttccacctt gtacttgcaa tctcagcagt atccgttgca tttatgtgtc catgtatgag
      541 ctttgcggca actgtgctga tcaaacatgc accggcaagt cagatcattc ccacatggct
      601 ccagacaaca gcaatgaact ttccgatggc attcttctgg cagatctttt atgccggacc
      661 attcgtaaga tttattttcg gaaagctttt cccggagaaa gaaaaggcag cagcttctgc
      721 cgaataaaaa atatgtaatt ttgactgcag cattctgtat ttcaggatgc tgcttttttg
      781 tgttcttatc tacacaacat aaattgtact tattttaata cactattgac aaattctgtc
      841 atttcttgta atatcatata aaacatatcg aataactatg aaaagtagag aatgcaaaaa
      901 ctactggtac cttaaaggag atgaaacatg atcagaaaat tatttgcctt tggtcttgca
      961 gttgtactgg cactgatgcc ggtacaggct tttggaaaaa cggtgtctat cactaatgtt
     1021 tcctatgatc ctaccagaga gatgtttgaa cagtataata aaatatttga agaccactgg
     1081 aaggagaaga ccggggatga tgtggaagtg atacagtccc atggcggttc agggaaacag
     1141 gcgcttgagg tagccaatgg tctggatgca gatgtggtaa ccctggcact ggaatatgat
     1201 attgagtcta ttgaaaacgc agggctgatc aaggcaggat ggaaagataa atttgacaat
     1261 gacagttctc cttatacatc cactatcgta tttctggtga agaaaggaaa tcccagggat
     1321 atcaaagact gggacgatct gacgaaaaaa ggagtgggag tagtaacacc aaatccgaaa
     1381 acctccggcg gtgccagatg gaactacatg gcagcgtggg cttacgcaga taaaaagtat
     1441 ggtggcgatg aagcgcagat gaaggaattt attaagaaac tttaccggaa tgtggtggtt
     1501 cttgactcag gcgcaagagg tgcaacgacc tctttcgtgg agaacggaca aggagatgtg
     1561 ctggttgcgt gggaaaatga agcttatcta tccatgcggg attatccgga tgagtatgag
     1621 attgttactc caagcgtaag tattctggca cagccttctg tggcggtggt agatgaagtg
     1681 gtggattaca gagatacaag agatgtggca acagagtatt tgaattatct gtattccgac
     1741 gaagcacagg agatcgcagc agagaattat ttccgcccca ccaatgagaa aatcctgaag
     1801 aagcacagtg atacgtttga tctgaatata aatctggcaa atatcagtga ttatggcgga
     1861 tgggataaag tgcaggagaa acatttcaca gatggcggaa ttttcgatca gatttatgag
     1921 agataaagga agacaagatg aagcaagagc ataagcacag acagaatata tgagacagga
     1981 gaggtggtaa ttgattatga aaaaaagaaa taaaccggtg attccagggt ttgggctctc
     2041 catgggaatt accatttcca tattgagtct ggtagttctg attcccctgg caagcctggt
     2101 ggtctacaca gcgaagctga gttttaaaga ttttatcgaa accatcacaa gggccagagt
     2161 gctggcatcc ttttatacca gttttgtatg tgcttttgca gcagcagtaa taaatggaat
     2221 tatgggaact attcttgcgt gggtgcttgt gaaatatgat tttccgggca agagacttat
     2281 ggatggggtg atcgaacttc cctttgctct tcccacagcg gtagcaggta ttgcactgac
     2341 atccctgacc tcagattcgg gaattgtcgg cagctttttt gcaggattcg gtatcaagat
     2401 cgcatacaca agaataggta ttacagtggc tatgatattt gtaggaatac cgttcgttgt
     2461 gcgaagtgta cagccggttc tggaaaagat ggataattct tacagcgagg cagcaggagt
     2521 gctgggagca aagaaaacaa ctatcttctg gaaggtcatt tttccggaac tgaagcctgc
     2581 gatctttgca gggaccggac ttgcgttcgg aagatgtctg ggtgaatatg gaagtgttgt
     2641 atttatcgca ggaaataaac cctattatac agaaatcaca ccgctggtta ttatgtcaaa
     2701 gcttcaggaa tttgattatt caagtgcaac ggcaatcgca cttgtgatgt tggcagtttc
     2761 attttttatt ctgttcctta acagtatgat acagcagaga aatgcaagaa ttttaagagg
     2821 aggaaatgcc tgatggacaa caatgaaaag acttcggaga aaattacaaa atggctgctt
     2881 gtcgggatca gtgttctgtt tctggcagtc atgctccttc ttcctctgat cactgtgatc
     2941 acagaagcat tgcggagcgg atggaaggtc tatgcagctg cagtgacaga tgagtacacc
     3001 atcaaagcac ttcttcttac agtgaaggca acactctttg cagttgtttt taacactgtt
     3061 tttggtgttt ttgcagcctg ggcactgacg aagtttcagt tcaggggtaa aaagcttctt
     3121 accacactga tcgaccttcc ggttactatt tcccctgtta ttgcaggttt gatctttctt
     3181 ctgattttcg gacgacagag tcctgtttac ttttttctca tgaagttagg gattaaagtt
     3241 gtattctctg taccgggaat cattattgca actgtatttg taacctttcc ttttatttcc
     3301 agagagctga ttccggttct ggaagcagaa ggaagcgatg aggaggaagc agcagctctg
     3361 atgggagcag gtggatggac cattttctgg aagatcacat tcccgcatat caaatgggca
     3421 ttactgtacg gagttgtgct ctgtacggca agagcaatgg gagagtttgg agcggtatct
     3481 gtactttccg gacatttaag aggaaagacc aatacacttc ctcttcatgt agagattttg
     3541 tttaatgagt ttcagtatgt tccggcgttt gccgtatctt cactgcttgt gatcatggcg
     3601 gttatcattc tggtagtcag aagcctgatt gaatataaag gaaagaagga agcctgatat
     3661 gtatgtagag ttaaaaaata tcaataagac atatggttct taccaggcat caaggaatgt
     3721 aaatttcgga attgagaaag gtaaactgat tggtctgttg ggaccaagcg gaagcggaaa
     3781 aacaactatt cttcgaatga tcgcaggtct ggaaaccccg gacagcggag aggtcattat
     3841 tgatggaaaa gtggtaaatg atgttccggc cagtcagcgt gggattggat ttgtatttca
     3901 gaattatgcg ttgtttcgct atatgacagt ttatgacaac gttgcatttg gtttgaaggt
     3961 tcagaaggct gataagaaga aaattgatgc cagagtcaga gagctgatca aactggtggg
     4021 gctggaagga ctggaaaaaa gatatccaag ccagttatcc ggcggtcaga ggcaaagggt
     4081 ggcatttgcc agagcccttg ctccaaatcc ccaggtgctg cttctggatg agccctttgc
     4141 agccattgat gcaaaaatcc gtcaggaact gcgaagctgg ttaaaagaga tgatcgggaa
     4201 gctgggaatt accagtattt tcgttactca tgatcaggat gaggccattg aagtagcaga
     4261 tgagattatt atcactaatg caggacggat cgaacagaaa ggaactccca taggggttta
     4321 cagaaatcct gagacagctt ttacagcgtc cttcttcgga cagccatctg tgttgaaaaa
     4381 tgcggatgat ttccatacct ttgctcaggc agaaggagca gacaagatca ttgtccgccc
     4441 ggaatttgta aaaatctcca aactggatga ggtggagaag ttcaaaactt ccgtatcccg
     4501 gggagtggtt gaacgggttt ctttcagggg agataatctg gaacttcagg tgagagtcaa
     4561 caattccgta gtaactgcca gaagaagcct ggagaaagca gatatccggg aaggtgagac
     4621 tgtgaatgta ttcctttaca ggatttttgc actgaggggt gacagtgtac agctgatcga
     4681 aaatgaggct gtaagggatg actttgtaat tatctgacag cggtggctgc ggcgactgac
     4741 gacaatgaag aaataagaaa ttcagaggca agactgatcg gaaaatcaac ttgttggcac
     4801 actggtatgg aggaaagggt aagagagaat gagaacagag agaatcagga cagatgtgct
     4861 gatcatcggc ggcggtacgg caggatgctt tgcagcctat gtgatcggca aaaaaagcgg
     4921 cagaaaagtt ctgatcgcag agaaagcgaa tattaagcga agcggatgtc tggcggcggg
     4981 cgtgaatgca ttgaacgcat atattacaga aggcagagtg ccgcaggatt atgtggatta
     5041 tgccaaaaag gatgcccatg gaatcgtaag agaagacctt cttcttacca tgtcagagag
     5101 actgaatcat gtgacaaagg tgatggaaga tctggggctg gtcatcctga aggacgaaaa
     5161 cggaaaatat gttgccagag gaaaccgaaa catcaagatc aatggcgaaa acatgaagcc
     5221 aatccttgca aaggcggcag ctgaacagga gaatgttacg gttctcaatc atgtaaatat
     5281 tacagattat aaaacagaaa acaaaaaagt cacaggcgca gttggattta gcgttaatga
     5341 ggatattttc tatgacattg atgcgaaagc agttctttgt gccacaggtg gtgcagcggg
     5401 actttacaga ccgaataatc cgggattttc cagacataag atgtggtatc ctccgtttaa
     5461 cacaggtgca ggatatgcaa tgggacttct ttccggtgcg gagatgacaa cctttgagat
     5521 gcgtttcatt gcattgagat gtaaggacac aattgctcct acaggaacta ttgctcaggg
     5581 tgttggggcc agacaggtca atgcacatgg tgatatttat gaaacaaaat atggtctgac
     5641 aacttcccag cgagtttacg gtacagtcat ggagaacaga gaaggaaacg gtccatgtta
     5701 tctcagaacg gaaggtattt ccaaagaaca ggagcaggac ctttacaaag cttacctgaa
     5761 tatggcaccg tcccagactc tgaaatggat ggaagccgga aaaggaccat ctgaagagaa
     5821 tgtagagatt gagggcacag agccatatat tgtaggcgga catacagcca gcggttactg
     5881 ggtagataat aacagagcta caactattga aggtttatat gcagccggag acgtagcagg
     5941 aggatgtccg cagaaatatg taaccggcgc actggcagaa ggtgagatcg cagcagaggc
     6001 gattttggaa tatctgaatg gcaaagatga tgaccggatc gcagcggaaa ataaggaaga
     6061 ggatttagag cgtggcggaa aacaggagct gtctcaaact gcaatagtta agaaggcaga
     6121 atacgaatca catttgaatg cttcccgttc tttgatgaat gcagagcagc ttgaggaagc
     6181 catgcagaag atcatggatc agtacgcagg aggaatcggt acagactaca gatacagagg
     6241 gatgagtctt gcaaaggcag atgaaaagat cgcagcattg ttgccagtag ttgacactct
     6301 ggcagcaaca gatacttatg aactgatgca gatttatgaa cttcgcgaac gactgatcgt
     6361 gtgccaggca gtgatcgcac atctggcagc cagaaaggaa accagatggc atagtttcgg
     6421 agagaataca gactacccgc agcagagcga agagtggatg aaatatgtaa actcccgtat
     6481 ggaaaacggc gagattaaga tcgtatatcg tgacctgata acaaaggaaa atacaggttt
     6541 gaatacagca gagaaaggag caggtgagag atgagcattc ggattcagaa aagtaaatgt
     6601 gcaggatgcg gcagatgtat cgaagcctgt cccggaaatc tgatcaaaaa ggataaagag
     6661 aacaaagcct ttatccgtca ggtaagagac tgctggggat gtacttcctg tatcaaggaa
     6721 tgcaggcatg atgccatccg cttcttcctt ggagctgatg tgggaggcag aggtgcaagt
     6781 atggttgtat cagagaaacc ggatatttcc acatggacag tggagaagcc ggatggcact
     6841 aagatcacta ttcaggttaa taagaaagac gctaataaat attaaacata agtatgtact
     6901 ctcagagtct ttagagtgtg tttgaaaaat gctttacgca agatgtgcgt cacaatttgt
     6961 gggagatttt gttcggatga gggcgtcgta gtgggctacg acaaccgaat tcggacaaaa
     7021 tataccgcaa agtggggcgt gcagattgcg ggaatgattt ttcagacacg ctctagtgta
     7081 tttgctcaag tacgaaaaga ttccgagtat aaacaaacag aggaggataa tgcaatgagt
     7141 aacttatctc atcttgatgc gcttgaggca gaggcgattt atattatgcg agaagtagca
     7201 gccgagtgtg aaaagccggt tatgctctat tctataggaa aggacagctc cgttatgctc
     7261 catctggcga tgaaggcatt ttacccggag aaacctccat tcccgttcct tcacattgat
     7321 actacatgga aattccatga gatgatcgaa ttccgcgaca gaatcgcaaa ggaaaacgga
     7381 attgatatgc tggtttacac caatgaagag ggtgtaaagg caggaatcaa tccatttgac
     7441 aatggttctg catatacaga tatcatgaaa acacaggcgt taaaacaggc tctgaccaaa
     7501 tatggattta cagcggcatt tggaggcggc cgtcgtgatg aggagaaatc cagagcaaaa
     7561 gaaagaatct tctctttccg taattcagct caggcatggg atccgaaaaa ccagagaccg
     7621 gagatgtgga agctttataa cactaagatc cagaagggag agagtatgcg agtattccca
     7681 atttccaact ggacagaaaa ggatatctgg cagtacattc agcgtgaaaa tatcgaaatt
     7741 gtaccgttat attttgcgaa agaaagaccg gtcatctaca gagacggaaa tattattatg
     7801 gtggatgatg acagattaaa actccgtccg ggtgaaaaga ttgaaaacaa aaaagtcaga
     7861 ttccgtactc ttggatgcta tccgcttact ggaggtattg aatctgaagc agatactctg
     7921 gatgagatta ttgatgagac gttaagtgct gtttcttctg aacgtaccag cagggtgatc
     7981 gaccacgagg cagcaggcag catggagaga agaaagagag aggggtattt ctagaatgaa
     8041 aggattattg aaatttatta catgcggaag tgtggatgat ggaaaatcca ctctgatcgg
     8101 acatattctt tatgatgcaa agcttctcta tgcagatcag gagaaagctc tggaactgga
     8161 ttccaaagta ggaagcagag gcggtgccat tgattattct cttcttctgg acggtctgat
     8221 ggcagagcgt gaacagggaa tcaccattga tgttgcatac cgttatttta caacaaataa
     8281 cagaagcttc attgttgcag atacacccgg acatgaagaa tatacaagaa acatggcagt
     8341 gggtgcgtcc tttgcagatc tggcagttat cctggtggat gcttcacagg gagtattggt
     8401 acagacaaga cgtcatgcaa gaatctgcgc attgatggga atccgttact ttgtatttgc
     8461 agtaaacaaa atggatctta ttgaatatga tgaaaaacgt ttctgcgaca ttgagaatca
     8521 gattgcagca ctgatagaag aactgaaact tgccaatgta actattgttc cggtatctgc
     8581 cacagaaggt gacaacgtta caaccaaatc tgacaacatg ccatggtata aaggtgaggc
     8641 gcttctttcc catctggaaa ccgtagacat taaggaagat acagagaagg gcttctatat
     8701 gcctgtacag agagtctgca gaccaaatca tgagtttcgc ggattccagg gacagattga
     8761 aaatggtgcc atcagggcag gcgaccttgt gactactctt cccagtaaag aagaagctca
     8821 tgtaaagagt attcttgttg gcgataaaga agttcaggaa gctgtacagg gacagcctgt
     8881 taccatccag cttgacagag aagtagatgt ttcccgcgga tgtgtactta ccattgattc
     8941 cggcgcagtt cttacagact ctgtggaagc agatatcctc tggatggatg acaatgctct
     9001 tacggatggc aagaacttct ttgtaaaaat cggtacaaag atgatccccg gcctggttac
     9061 aaagatcaat tattctgtgg atgttaatac aggtgaaaag aaaagcgcat ataccttaaa
     9121 gaaaaatgag attgcttcct gtactctgga attctcagag aagatcgttg tagacgaatt
     9181 tgacaggcac agaacactgg gtgagctgat cctgatagat cgtgtcacaa atatgacttc
     9241 tgcctgcggt gttgtgagaa aaacctttgt ttctcaggat agatctcaga tcggaaaagt
     9301 ggacgagcag gttcgtgcag gactgaaagg tcagacaccg gtagtagtgg aattcccgat
     9361 cggtaaagaa ggaatcactc ttgattttgc agagcaggta gaaaagggac tgactgtact
     9421 tggaaaacat acctatctgt atcatccggc agcgagtgaa aactatgcag aaactgttcg
     9481 ccatcttaag gcagcaggtc tgatcgtact tcttgttctt gatgaaaata cagcaaaaga
     9541 cgagacatta aagactctgg atggtttcta tgcgaactgg cagattgacg gaatcactgt
     9601 gaaagatgcg attgatttcg tgaaaaagaa atctgcattt acagtgcaga gtgtacatga
     9661 tggaaattat atctgattat aacagggcta taaatcgccg cagagacaaa gaaagtctct
     9721 gcggtatttt gttttcttga caagtgtcgt tacagcagat tatacttatt ctcaaatatt
     9781 cagaatccat aataatacag acaggaaaga taacagaaat atgcaaacga acaatgaaag
     9841 taaacaaaac caaaaaaaag agatgcttct tggaactttg tttgtaattg ctacgatcat
     9901 tattctggcg ataccaacga agaaaagaca gaaataaaga tgagtgaata tcgatcagaa
     9961 tgtagaatgg gcaattggtt actgttcaca caccactatc ccgcgaggtg ttttggcatg
    10021 aatatgccaa aatcccgaga catacaagcc aaaattccat tgccacaggc aatctgaaat
    10081 gaattttggc taagttactg taaacggagt gaacagtaac ggcaattgtg cagtggcatt
    10141 cagattacat attatgcagc agagtatgat ataatttgtt ttgtataatg gcgtcaggat
    10201 taagagcata tgtagagttg tgtagtgaag cggattgcga atatctgttt gacttttgat
    10261 gggtgtacac gagaacattt ttttacagtg aaagttatct gtattatatt acagagggta
    10321 ctgtacagat aatcaggagg tattttatgc gtttggaaaa agtacaggaa gcgttaaaaa
    10381 caaagaaaat tcattatgaa tatacagagg aaaacggatg cggaagcatc gactttatgt
    10441 ttcgcggtct gagattccat atatgggaat atgaagatcg tgtctgggga gcggagacaa
    10501 acgtgttcga agcaggcaga agccaggata ttgagggaga ttacgaggaa attatttccg
    10561 gagaaatcct ctcatggccg gatatgctgc ctgggatgta agtattactg cagaagggaa
    10621 tgatatttac gaaaaaatat agaaccggac aaattgtatt aactgcatgt attgtagctg
    10681 tctgtatgtt ttcaaatgtc catgggacag aagcggcagg tccgccggca ccgaaaactc
    10741 tgacagttac accgacagaa aaatcgaaat caacagcaaa gtctgcgtca acatcaaagt
    10801 ccaaatcaac accgaaatcc aaatcggcac taacacaaaa acctgaagca acaccaatac
    10861 ctgcatctac tccaacacca gagcaggaag ctgagacaga taaacagaat ccggcagatc
    10921 agggaacttt aagcaagcca gatcatccgg atactatctc cgcagataaa ctggtattta
    10981 tcggagattc cagaacagag ggattgaggg atgcggtaaa tgatgacagc atttggtcct
    11041 gtctttcttc tatgggatat gactggatgg tatctacagg agtgcctcag gtagaagatc
    11101 agattgagga caatacagcg gttattattc tgatgggtgt taatgacctg tatcatgtta
    11161 atgactacgt cagctatatt aattccaaag ctgccgaatg gggaaacagg ggagcgcaga
    11221 cttattttgt gtctgtaggt ccggtgcaga atgatcccta ttgcagtaat gcggagattg
    11281 aaagcttcaa tgcggcaatg caggcaaatc tgagtggggt tacctacata gatgtatatt
    11341 cccatctggt atctgaggga ttttccaccg tagacggaac ccactatccg gacagtgtgt
    11401 ctgtagatat ttataattat attctggatc atctggagga acagaggagt ggaatctggg
    11461 gatgattttt cagtttatga aattgtgatg ctgtattgag ttcgatggag tttggtgata
    11521 tgattgcaga ggaaaaaacg aaatagagcg gaaattcgtt tttatataaa agctgaaaac
    11581 ctggtaggag gaaataatga gtggctgttt tgcagcagag ccaaaaatgt aaatgataat
    11641 tgcccgatga ctggacagtt atcaaaatcc aaaatcagga ggaaagaatg agaggactgt
    11701 attcatccaa aacagaaatc agacacaaaa tttttacgga aattgcgagg atggcatatg
    11761 aaggccagtc tccggagatg ctggaagagc ttccctacaa gattgtaccc ggtgaaattg
    11821 cgacttatcg tgacagtatt tttctggaaa gagcggtagt tggtgagaga cttcgcgttg
    11881 caatggggat gtcactgaga aaggttacag agcatgcgcc aatctctaaa ggtgtggaag
    11941 ccagcgttat tgaggaaaag tattatgaac caccgcttat caatgtaatc aagtttgcct
    12001 gtaattcctg ccctgagaaa agggtaatga tcacagaggg ctgtcagggc tgtctggagc
    12061 atccctgtgt ggaggtctgt ccaaagaaag cagtacatat ggaaggcggc agatcacata
    12121 ttgatgaaga tgcctgcatc aaatgcggaa agtgtctgga agcctgtccg tataatgcaa
    12181 tcatcaaaca ggaacgtccc tgttcaaagg cctgtggcat gaatgccatt ggttctgacg
    12241 aatacggaag agcggagatt gaccaagaca aatgtgtatc ctgcggacag tgtctggtga
    12301 gttgtccgtt cagcgctatt gtagacaaag gacagatttt ccagactgtt atggcattaa
    12361 aaagtgaaac accggtgtat gcaatcgtgg cgcctgccat tgcaggtcag ttcccaggta
    12421 tggagaataa taagatacgg ggtgcatttc aggcacttgg ctttacagat gtaagagagg
    12481 ttgcagtcgg tgcagatctg tgcacagtgg aggaggcaaa ggactttttg gaagaagttc
    12541 ctgagaaact tccgtttatg gctacatcct gctgtccgtc ctggtctatg atggctaaga
    12601 aattattccc ggaacaggcg aaatgtatct ccatggcact gacacctatg gttcttactg
    12661 ccaggctgat caagcagaag gaaccgaatt gtaagatcgt tttcgtaggt ccctgtgcag
    12721 ccaagaagct ggaagccagc cgtaagagta tccgcagcta tgtggatttt gtgctgacct
    12781 ttgaggaagt ggcaggaatg tttgatgcca aaggcgtgga ctggaaagat attccagaag
    12841 gagagccact gtttcgtgcc agtgctgacg gaagaggttt cgcagtcagc ggcggtgtgg
    12901 cagaagcggt tgtccatgta gtgaagcgta ttgatcctga tcgggaagta aaggtaatga
    12961 atgcagaagg tctgcagaac tgtaagaaga tgctccagat ggccaagatt ggtaaatata
    13021 atggatatct gctggaagga atggcatgtc cgggcggctg tgtagcaggt gccggtacta
    13081 tccagacagt taaaaaagca gcagcggctc tcgaaaaaat gaagaaagag gctttgttta
    13141 cagatgccta tgactccaaa tacagagcaa gactggaaag tctggagaaa tttgatgtgg
    13201 agtgagattc tgactgaatc agtgaaatcc tatatggatt gcaagtgttt gaatgcaatc
    13261 agtatatagc agactaaaaa tgaataatca tcagaagaac tgtcaggctg agtgataagt
    13321 ttaactgaat agggtaagtc ccctgcggag gttgcgaaaa gcaataagca ggggactttt
    13381 gtcagctatg tacaatattg acttaaatca aaaaaagttt catataagtc atgaaataat
    13441 taacagtatg ttgactgaga ttttatagaa taacaaatta agtcaagcga acaggcaaaa
    13501 atatttgact ggaaatttat aaatagcaaa ttaggtcaag aaatt
//
