LOCUS       c00065_gnlPro..        12093 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JPGIKCND_65.
ACCESSION   c00065_gnlPro..
VERSION     c00065_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 23:09:13
            Original ID  :: gnl|Prokka|JPGIKCND_65
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12093
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..741
                     /locus_tag="ctg65_1"
                     /transl_table=11
                     /translation="HTLFPDEIPEKMWLLPIRNLLFLGKASEQKLLNQGIRTIGDLARE
                     RASNVQYWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPIL
                     LEQCDVLATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKE
                     FWKGQPLRLIGVALTGLTDGTYEQMSLFEDTENKERHRKLDAAMDEIRMKFGNDKITRA
                     SIMNSNARIGRKAKAQMKNENTEE"
     protocluster    1..12093
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[812:6401]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      813..6401
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12093
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12093
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(813..1322)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_2"
                     /sec_met_domain="ALS_ss_C (E-value: 4.3e-23, bitscore:
                     70.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(1340..3058)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.7e-49, bitscore:
                     157.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIKLAESYRA
                     KGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
     CDS             4117..4671
                     /locus_tag="ctg65_4"
                     /transl_table=11
                     /translation="MDYLSNNVAVNLKRIRKSKSMSLDQVSEQTGVSKSMLAQIERGTA
                     NPSLGVLGKITSGLRIEFQELIQPPRVDCCLVTPAELVPTKEIAGQYRVWTCLPYEDTR
                     LVEVYRIEVEPGGVYISGSHGEKTREYLAVMEGVLTLECHGEKYEIHRDQVFKFETDQE
                     HVYRNTGKEKACCTCFFLDYH"
     CDS             5184..6401
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: Beta_elim_lyase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_5"
                     /sec_met_domain="Beta_elim_lyase (E-value: 1.2e-08,
                     bitscore: 23.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_3 (E-value: 1.5e-110, bitscore:
                     358.9, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLKDTGLTFQDIKDKVNKYMIETYERFDFLAETAEGMYIYDENK
                     TPYLDFYAGIAVNSAGNCNPKVVAAAKDQLDDIMHTFNYPYTIPQALLAEKVCETIGMD
                     KIFYQNSGTEANEAMIKMARKYGIEKYGPNRYHIVTAKMGFHGRTFGAMSATGQPGNGC
                     QVGFGPMTYGFSYAPYNDLQAFKDACTENTIAIMVEPVQGEGGVHPATMEFMQGLRKFC
                     DENDMLLLIDEVQTGWCRTGAVMSYMNYGIKPDIVSMAKALGGGMPIGAICATAEVAKA
                     FTAGSHGTTFGGHPVSCAAALAEVNELLDRDLAGNAKKVGDYFAAKLEKLPHVKEVRHQ
                     GLLVGVEFDDTIGGVDVKHGCLDRHLLITAIGAHIIRMIPPLIVTEEECDKAVAIIEDT
                     IKSLEK"
     CDS             6631..7251
                     /locus_tag="ctg65_6"
                     /transl_table=11
                     /translation="MKHLVITIGCEYGAKGNAIGKKIAQDLGIKFYDRDLVDEIIKEVG
                     IPTDIMDRVEEGGTIAGKGAQGDVRGSFSKYADLTDRAIHVQKQIIRKLAQKEACVIIG
                     RSADYILKDTEGIQLVRAFIYAPNDVRIHNIMESHNLSEKDAKLLLDEKDKRYHKRHLA
                     LTGSNRGDRHNRDILINSDFLGIQGTAEYLEDLIAKKYGKKEA"
     CDS             7255..8775
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AA_permease_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_7"
                     /sec_met_domain="AA_permease_2 (E-value: 5.1e-47, bitscore:
                     149.9, seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQKTSEFDKVLGAWDILVIAFGAMIGWGWVVSSGNWIESGGVLG
                     AAIAFAIGGIMIFFVGLTYAELTAAMPQCGGEHVFSYRAMGSTGSFICTWAIILGYVSV
                     ACFEACAFPTIITYLWPGFLKGYLYTVAGFDVYASWLIVAIVIAFLIMIININGAKTAA
                     VLQTVLTCIIGGAGIILIVASVVTGSVDNLQGQMFVGNGTGEAMKSIIKVAVITPFFFI
                     GFDVIPQAAEEINVPLKKIGKMMILSVVLAVVFYSLVILAVGFILNPAEIIESQQGTGL
                     VTADAMAKAFGTKVMAKVIIVGGMCGIITSWNSFLLGGSRAMYSMAESYMIPPFFAKLH
                     PKHKTPVNSLYLIGALTMLAPFAGRTMMVWICDAGNFGCCLAYCMVSVSFLILRKKEPD
                     MARPYKVGHYKFVGFMAVVMSGLMLLVYCIPGSGGSLVFQEWLMVGSWSLLGVVFYAIC
                     KRKYKEDFGKLIELISDEDAASLMPEADDEELDVVIDAAIDRVLSSMA"
     CDS             9061..10245
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:Iron-containing alcohol dehydrogenase (Score:
                     373.9; E-value: 2.3e-114)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_8"
                     /sec_met_domain="Fe-ADH (E-value: 3.7e-115, bitscore:
                     373.9, seeds: 219, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPFEFFIPQNITVGAGTLAKLPECAKKLGGSHAMLISGPTLRKM
                     GVVDKAADYLKDAGMAVDIFTDVEANPSVTTVEKATEAYKDSGADFIVALGGGSPMDVA
                     KAVGVTAKYGGSITEYEGAHKVPGKIVPLIAIPTTAGTGSEVTAFSVITDHSRDYKLTV
                     FSYELLPAYAILDPELLTSAPASVAAACGIDAFIHAEEAYVSTAASPFSDAMAEKAMEL
                     IGGNIRRFVARRTDLEAAEAMLTGSLFAGIAFSFARLGNVHAMSHPVSAFFNVAHGVAN
                     AVLLPVIAEYNALADHGRYLKIYNYISPISAYEDEFEPLMLVDAIRELNEDIGIPEDLT
                     TAIRQAKKGEEISDEEIESKIDAMADDAMKSGNIAVNPRSSRKQDIVKLYYKAL"
     CDS             10515..11171
                     /locus_tag="ctg65_9"
                     /transl_table=11
                     /translation="MAKKKIYAVRKGHKTGLFATWAECQKAVNGYSGAEFRGFTEKEEA
                     LAFLNMETTGNVFGDKAKEAAEIVEVPENMVIAYVDGSFEKSIGRYAFGCVILTPDGQE
                     IRKSGSGSDSAGVAIRNVAGEMLGSMTAVNWAIENKYPAVEIRYDYEGVEKWVTGVWRA
                     KIPLTSKYVAYMQEAGKKVKISFCKIAAHTGNHYNEEADQLAKSALLKADEEVRI"
     CDS             complement(11344..12093)
                     /locus_tag="ctg65_10"
                     /transl_table=11
                     /translation="VLMVISLIIIPRTAQAASVKLNKTKLTMNVGGVYHLKVSGTNKKV
                     TWSSTDSKVASVSSGKVKAKKTGTATITAKIGSKKLKCQIKIKDQRALYEKVLLQSGGK
                     CFYLMDIDRNGTPDLIVSSNRGVIVDYSVYTIKNGKVIYAGQCSGKGMNYQILQYNTHY
                     NGIHISWWTNGVGGSGSALWTLSGSKLVSTSRAYCSVAGFQTGKDEQHMKNVSQTSFNS
                     YCDKHFRNCKQYTMWSNTSENRIKHLK"
ORIGIN
        1 cacactctgt tcccggatga aatcccggag aaaatgtggc ttcttcctat ccgtaatctg
       61 ctgtttctgg gaaaagcttc cgagcagaag cttctgaatc agggaatccg taccatcggt
      121 gatctggcaa gagaaagagc atccaatgtg cagtactggc ttggggaaaa aacgggacat
      181 cagctatggc aatatgccag aggtatcgat gattcccctg taaaagcagt gcctgatgag
      241 gcaaaaggtt tcagcgtgga aactactttt aacgatgata ttacttccat agagcaggtg
      301 tttcccatac ttttggagca gtgtgatgtt ctggcaacca gaatgcgcag aaaagataag
      361 aaatgcaact gtatttccgt gactttccgt actttggatt tcagaaaccg ttcacaccag
      421 acaaagctgg aaaatgctac agatcttaca gatgaaattt atataaatgc tacaagactt
      481 tttaaagaat tctggaaagg acagccgcta cgtctgattg gtgtggcact gacaggcctt
      541 acagatggca cttatgaaca gatgtctctg tttgaagata cagaaaataa agaacgccac
      601 agaaagctgg atgcagctat ggatgagatc cggatgaaat ttggaaatga taagatcacc
      661 cgtgccagta ttatgaacag caatgcacgg attggacgaa aagcaaaagc acagatgaaa
      721 aacgaaaata cagaagaata gtaagtaaag ggaggactga gcattaagaa taatgcgaca
      781 atcctccctt tataaaaaat tcagaaaaag ttttatcgtt ccatcatact gatagattcg
      841 attcctacac ttcctccacg taccacttca attctgtgaa attcttcctt gatcagtttc
      901 actactgcgt cattcttggt tgctgtctgg acaaattcca ggagtagact gtctttgccg
      961 tagtcaatga cctttgcctt gaaggtttcg gcaatctgaa acagttcaac cttatcttct
     1021 ttggaacagt taaaaacctt aatatacaga atctctttca tgcggacaaa tacgtctgtg
     1081 aaatcaataa ccttaataac ctcgatcata cggttcaact gttttttgat ctgttcaaaa
     1141 gtttcatcat cactgacagt tgcgatcgtc attcgagata ctgtggggtc ctcggtggtt
     1201 cctacagtaa gactgtccag attgtagctt tttccggaga aaagtccgga gattttggac
     1261 agaacaccta cctggttctc aacatagaga gaaatccatc tttttttcat tcctttatcc
     1321 ataataattt tcctcctgat caacagtcca taatcatatc ttctagagtt ccgcctggtt
     1381 tgatcatagg ataaaccatt tcctcagggt caatgatgaa ttcaattact gtaggtgcct
     1441 ttgtgttctt ttttgcttcc tcgaaggctg ctgcaatttc ctctttcttt gtgacacgga
     1501 ttccttttgc cctgtagctt tctgcaagtt taatgaaatc cggtgtgtac tgtggatatt
     1561 ccatgccttc tgtgcggcgg gaaagtgctc ctgcgcgcag attggtcata gcatagcgtt
     1621 tgccgtagaa aagcttctgc cactggcgta ccattccaag gtattcattg ttaaagatgc
     1681 acaggataac aggaagttct tccagaactg cagttgcaag ctcctgaatg ttcatctgca
     1741 caccgccgtc accggagata acgatgaccg gtctgtcagg gtttccgatt ttggctccga
     1801 tgccgcctgg aagaccatag cccattgttc ccagaccacc ggacatgatc atctgtttgc
     1861 cctctgtgat ttccgcatac tgggagacaa gcatctgatg ctgtcctaca tctgttacga
     1921 taatactgtt ctcaaactgt tcgttgatct ctttcaggat atccatcgga cttaaaagat
     1981 catttggacg cattttaagc ggatgctctt ctttccagtt tttgatcagg ttaagccact
     2041 tgtccgttga acattcctgg acgtattcgt tcattttggt gatagcctct tttgcatcag
     2101 caacaatggg gatatccacc tgaatgtttc gggaaatgga tgctgtatca atatcaatgt
     2161 ggataatctg ggcatgtggt gcaaattcat gaagttttcc ggtgattctg tcattgaatc
     2221 tggttccgat ggagaacagc acatcgcagt tgctgacagc catgtttgct gcataggcac
     2281 catgcatgcc gaggtttccg atataaagcg gatggtcagt aggaatggaa cctttgccca
     2341 ttacggttgt gacaaccggt acttttgtct tttccactac ttcccggaaa atttcatggg
     2401 cgcgggagat tactacaccg ccgcctgcca ggaataaggg acgttttgct ttatttaaaa
     2461 gtttgatggc acgtttgagc tggccgatgt ggacatctgt gtttggtttg tatccgcgga
     2521 tgtttacatt tttaggatat tcagcgctgc cgagttctgc cattacgtcc tttggaaggt
     2581 cgataaggac aggccccgga cggccggtgc gggcaatgta gaaggcttct ttgatgatac
     2641 gtcccaggtc ttcacgtctg cggacagtaa caccgtattt ggtgatgctt ctggtgattc
     2701 ctacgatgtc tacttcctga aatgcatcgt tgccgatgag gtggcgggct acctggccgg
     2761 tgaagcatac aagaggtacg ctgtcatagt tggcggttgc aagtcctgtt acaaggttgg
     2821 ttgctccggg accgctggtt accagacata cgccgacttt gccggtggtt ctggcgtagg
     2881 cgtcggcttc gtggacaagg gcctgttcgt gacgggggag gatgattttg acatcgtcct
     2941 gtttgtagag ttcgtcactg atgtcgatgg tacaggcgcc ggggtagccg aagaggtatt
     3001 ctacgccttc ttcttttaag gctttgacta agagtttgtt gccggatatt tgtttcatat
     3061 ttgggtaaac ctcctttgtg tatgtggata ggacgctcag aaatttattt gttttcgggt
     3121 gcggtttcgg agtctagtac atcgtttcgt aaataactat accaatcgcg taggatgcgg
     3181 attcgagtgt gctggtataa aaacgcaggc gtagcgggct acgctgaggc ttttagacct
     3241 gtgcaatcgg attcgcagac aagtgagtgg tatagttatt tcgaaaacga tgtactagga
     3301 actctaagtg tctgaaaatc tgctaaaacc gttcagaaaa atctcaaact cgccgcagat
     3361 gcggctcaga cagtgagatt tttctgaaca acgcagattt ccaggcacta agagttacta
     3421 cgactcctgc aaatgcaccc gaaaacaaat aaatttccga gctgtgtgtt ggccaataca
     3481 gggggcagaa tggcgctgcg ctgattctgc cgagtgtggg gtggcgggtt tgatgtgaca
     3541 gattaaagca agcacgaacg actttttgac cctgatatat aaatatagta aaaaacgccc
     3601 tgggcttgtt tgcccagggc gaaaatgttt tccgcggtac cacctgtatt cagagtctgg
     3661 ctctgcactt tgtcagtact gatatactgt gttcctgtaa cgtggaactg acgttgaagc
     3721 ctacttggca tgtccgttca ggtcttgtgg atcagacggg atatgcggtt tggttcactg
     3781 ctcgggggct acttccacaa ttcgttcaca aaagctcgca ccgaccgctt tctctctgtg
     3841 cttcccgggg ttgtgtactc ctccctgtca tggcatttgg ctgatatagg gatattcatt
     3901 gtccgaatag ggtggacaaa tgttttcttg ggttacatta tacatttata gagaggaaat
     3961 tgtcaaccgg gttttggata attgctataa aatttatgtt cctgaatgaa ttttggctac
     4021 gttactgaga acggagtgaa cagtaatgta attgacagat ttctatattg ctgatataaa
     4081 aaataaataa tacagttgtt tggaaggagg ggacatatgg attatttatc gaataatgtg
     4141 gcggtgaatc tgaagaggat tcggaaatcc aagagtatga gtctggatca ggtgtctgag
     4201 cagacggggg tgagtaagag tatgctggct cagattgaga gagggactgc caatccttct
     4261 ctgggtgtgc tggggaagat tacaagtggt ctgaggatag agtttcagga gctgatacag
     4321 ccgccgagag tggactgttg tctggtgaca ccggcagaac tggttcctac caaggagata
     4381 gcaggacagt acagggtatg gacctgtctg ccttatgagg atacccgtct ggtggaggtg
     4441 taccggatcg aggtggaacc gggtggtgtt tatatcagtg gcagccatgg ggagaagaca
     4501 agagaatatc tggctgttat ggagggtgtg cttactctgg aatgtcatgg tgagaagtat
     4561 gaaatccaca gagatcaggt gtttaagttt gaaacggatc aggagcatgt ctatcggaac
     4621 acagggaagg agaaagcctg ctgtacctgt ttttttctgg attatcattg atgcagttgt
     4681 atcaggagtt ttgttgctga agcggtctgc cgcaggtgga ttaccatagt gtagaactga
     4741 gtagtgaagc aggtgatttt atccgaagta tgagtgtaaa atgtgcaata taatgcacaa
     4801 aatgatgaaa aagatacacc aggaaatgaa tatctgaaaa gaaaggatgt atgtaatggt
     4861 ttgtcagtct gccatttcat gaagaggctg tgttgttatg aattgttgag aaacctttat
     4921 aatatcgcat gaatatgcag gaaatattgg atatacaata aggagaacac agagctttcg
     4981 ttactgttca ctccgttctc agtaacgatc tttctgtaaa aaatgtaaat gttcaaaaaa
     5041 catgttgaca aatcataagg gcagtgatat tgtaagggtg tacaaaataa tacacagaaa
     5101 aagttaagca aaggcgctta cccatacggg tcagtttgtc tttgcttttt tttattatct
     5161 taaggatgca ggagggcaca gctatgaaat taaaagacac aggattaact tttcaggaca
     5221 ttaaggacaa agtaaacaag tacatgatcg agacttatga gagatttgat ttccttgcag
     5281 agacagcaga gggtatgtac atttatgatg agaataaaac tccatatctt gatttttacg
     5341 caggtattgc agtaaacagc gcaggaaact gtaatccgaa ggttgtagct gctgcaaagg
     5401 atcagttaga tgatatcatg catacattca actatccata tacaatcccg caggcgctgc
     5461 ttgctgagaa ggtctgtgaa acaatcggaa tggacaagat tttctatcag aactctggta
     5521 cagaggctaa cgaggcaatg atcaaaatgg cccgtaaata tggtattgaa aagtatggtc
     5581 caaaccgtta tcatatcgta actgcaaaga tgggattcca tggaagaacc tttggtgcca
     5641 tgtctgcaac aggtcagccg ggtaatggat gccaggttgg attcggacct atgacttatg
     5701 gtttctccta tgcaccgtac aatgaccttc aggctttcaa ggatgcatgt acagagaaca
     5761 caattgccat tatggttgag cctgtacagg gcgagggtgg cgtacatcct gcaacaatgg
     5821 aattcatgca gggacttcgt aaattctgtg atgagaacga tatgcttctt ctgatcgatg
     5881 aagtacagac aggatggtgc agaacaggtg ctgttatgtc ctatatgaat tatggtatca
     5941 aaccggatat cgtatctatg gcaaaggctc tgggcggtgg aatgccaatc ggtgccatct
     6001 gtgcaacagc agaggttgca aaagctttca cagcaggttc ccatggaact acattcggcg
     6061 gacatccggt aagctgtgca gctgcactgg ctgaggtgaa tgagcttctg gacagagatt
     6121 tggctggaaa tgcaaagaag gttggcgatt actttgcagc taagcttgag aagcttccac
     6181 acgtaaaaga ggtaagacat cagggacttc tggtaggtgt ggaatttgat gatactatcg
     6241 gcggagtgga tgtaaaacat ggctgtcttg acagacatct tctgatcaca gctatcggag
     6301 cgcatatcat ccgtatgatc ccaccgctta ttgttacaga agaagagtgc gacaaagctg
     6361 tagcaatcat cgaagataca attaaatctc tggaaaaata aaaatccggc aacggagtga
     6421 tacagtaaaa ggacaagggc gtcacgaatt atattcgtgc gcccttttat gatatcagag
     6481 tcaaaaaatc aaaaagtcgt tcgtgcctgc acgataagac ttttgaactt gggacctgcc
     6541 aaatatgaga aagtagcgat ttacatagca aatcagtgga tttcgaatgt ttgagaatct
     6601 gataaaaatt tgagtgtgag agggaagagc atgaaacatc tggtaattac gattggctgc
     6661 gaatatggag ccaagggcaa tgccatcggt aagaagattg cacaggatct ggggattaag
     6721 ttttatgatc gtgatcttgt ggatgagatt atcaaagagg taggcatccc tacagacatt
     6781 atggacagag tagaggaagg cggaaccatc gcaggtaaag gtgcacaggg tgatgtgaga
     6841 ggttcctttt ccaaatatgc ggatctgaca gaccgcgcca ttcatgtaca gaagcagatt
     6901 atccggaagc tggctcagaa agaagcctgc gtgatcatag gacggtctgc agattatatt
     6961 ctgaaagata cagaaggaat ccagctggtg agagcattta tttatgcacc taatgatgtt
     7021 cgcattcata acattatgga aagccataat ctttcggaaa aggatgcaaa gcttctgctg
     7081 gatgagaagg ataaacgtta tcataagaga catctggcac tgacaggaag taaccgcggt
     7141 gacagacata acagggatat tcttattaac agtgattttc tgggaattca gggaacagca
     7201 gaatatctgg aagatctgat cgcaaaaaaa tacggaaaaa aggaggcctg acctatggaa
     7261 caaaaaacat cagaatttga caaagtactt ggtgcatggg acatacttgt aattgcattt
     7321 ggcgccatga tcggctgggg ctgggtagtt tcttccggta actggattga atccggtggt
     7381 gtgcttggtg cagctattgc atttgcaatc ggtggaatca tgatcttctt tgtaggtctg
     7441 acttacgcag agcttacagc agccatgcct cagtgtgggg gtgagcacgt attcagctat
     7501 agggcaatgg gttctacagg ttcttttatc tgtacctggg caatcattct tggatatgta
     7561 agtgttgcct gctttgaggc atgtgcattt cccacaatca tcacttatct gtggccgggg
     7621 ttcctgaaag gatatctcta tacagttgca ggctttgatg tttatgcatc atggctgatc
     7681 gtggcaattg tgattgcttt tcttattatg ataatcaaca ttaatggagc aaaaactgca
     7741 gcagttttgc agactgttct tacctgtatt atcggcggtg ccggaattat tctgatcgtg
     7801 gcttctgtgg ttacaggaag tgtggataac cttcagggac agatgtttgt tggaaacggt
     7861 accggtgaag caatgaaaag tattattaag gttgcagtta tcactccgtt tttctttatt
     7921 ggttttgatg ttatcccaca ggcagcggag gagattaatg ttccgctgaa aaaaatcggt
     7981 aaaatgatga tcctttctgt tgtgctggca gttgtatttt actcactggt gattcttgca
     8041 gtaggtttta tcttgaatcc ggcagagatc attgagtctc agcagggaac aggacttgta
     8101 acggcagatg ccatggccaa ggctttcggg acaaaggtta tggccaaggt tatcattgta
     8161 ggtggaatgt gtggtattat tacatcatgg aactccttcc tccttggcgg ttcccgtgcc
     8221 atgtactcta tggcagaatc ctacatgatt cctccgttct ttgcaaagct ccatccgaag
     8281 cacaaaactc cggttaattc tctgtatctg atcggtgccc tgactatgct ggctcctttt
     8341 gcaggaagaa ccatgatggt ctggatctgt gatgcaggta acttcggatg ctgccttgca
     8401 tactgtatgg tctctgtctc tttcctgatc cttcgtaaaa aggaaccgga tatggcaaga
     8461 ccttacaaag taggccacta caaatttgta ggttttatgg cagtagtcat gtcagggctg
     8521 atgcttctgg tttactgtat tccgggttcc ggtggaagtc tggtatttca ggaatggctt
     8581 atggtaggta gctggagttt acttggagtt gtattttatg cgatctgtaa acgtaaatat
     8641 aaagaagact ttggtaaact tattgaactg atctctgatg aggatgcagc aagtcttatg
     8701 ccggaggctg atgatgaaga gcttgatgtg gtaatcgatg cggctattga cagggtgctt
     8761 tcctctatgg cataacgcta taaatgacat gacaattatt gctagtacat cgttttcgaa
     8821 ataactatac cactcacttg tctgcgaatc cgattgcaca ggtctaaaag cctcagcgta
     8881 gcccgctacg cctgcgtttt tataccagca cactcgaatc cgcatcctac gcgattggta
     8941 tagttattta cgaaacgctg tactaggaat tattttgggt aacagagttt tgaatttgtg
     9001 caaggtagat gccctgcaca ttgcaatatt gaaaaaatac aggaaaagag gcagaaatta
     9061 atgaatccat ttgaattttt tattcctcag aatattacag tcggtgcagg tactctggcg
     9121 aagcttccgg aatgtgccaa aaagcttgga ggttctcatg caatgctgat ctcaggacca
     9181 actctccgga aaatgggagt tgtggataag gcggcggatt atctgaaaga cgccggaatg
     9241 gcagtggata tttttacaga tgtagaagcc aatccgtctg tcaccacagt ggaaaaagcg
     9301 acagaagcgt ataaggattc cggcgcagat tttatcgttg cgctgggcgg tggttctcct
     9361 atggatgtgg caaaagcagt gggagttacg gctaaatatg gcggcagtat tacagaatat
     9421 gagggggcac ataaggttcc cggaaaaatt gttccgctga tcgcaatccc gactactgcg
     9481 ggaaccggct cagaggttac ggcattttct gttatcactg accacagcag agattataag
     9541 ctgacggtat tcagttatga acttcttcct gcatatgcga tcctggatcc tgaacttctc
     9601 acatctgctc cggcatctgt ggcagcagcc tgcggaatcg atgcatttat tcatgcggag
     9661 gaggcttatg tttccacagc agcatctcct ttttctgacg caatggcaga gaaagcaatg
     9721 gagctgatcg gtggaaatat ccgccgtttt gtggcaagac gtacagatct ggaggcagca
     9781 gaagcaatgc ttacaggctc tctttttgca ggaatcgcct tttcctttgc aagacttgga
     9841 aatgtccatg ccatgagtca tccggtaagt gctttcttta atgtggcaca tggagtggca
     9901 aatgcagttc ttctccctgt gattgcagaa tataatgcgt tggcagatca tggcagatat
     9961 ctgaagattt ataattatat cagtccaatc tctgcatatg aggatgaatt cgaaccgctg
    10021 atgctggtgg atgccatccg ggaattaaac gaagatatcg gaatcccgga agacctgacc
    10081 acagccatcc gccaggcaaa gaagggagaa gagatttctg atgaggagat tgaaagcaag
    10141 attgatgcca tggcagatga tgctatgaag agcggaaata ttgcagtaaa tccaagatcc
    10201 tccagaaagc aggatattgt gaaactgtat tataaagctt tataagataa agaataatgc
    10261 agtattttat gtgattgcta caggtaggat attgattaaa aatatctgtt attataaaaa
    10321 acgtgcagag acatcgaagt cgacagataa cttcaggctt gaaggtttat ctcgatttca
    10381 aaatgtatct gcacgttatt tttttgagaa atttccattg tataacttgc ctgatagaaa
    10441 gaaagattat atagtattaa tcaaaatata gtaaagtaat gtgggtcaaa atattgattg
    10501 ttcaggagga ttttatggca aagaagaaaa tatatgcagt acgcaaggga cataaaacag
    10561 gactttttgc tacatgggcg gagtgccaga aggcagtaaa cggatattca ggagctgagt
    10621 ttcggggatt tacagagaaa gaggaagcat tggcttttct gaacatggag acaacaggaa
    10681 atgtattcgg tgataaagca aaagaggcgg cagaaatcgt ggaagtacct gaaaatatgg
    10741 tcattgctta tgtagatgga agtttcgaga aaagtattgg cagatatgcc tttggttgtg
    10801 tgatccttac accggatgga caggaaatcc gtaaatccgg cagcggcagt gattctgcag
    10861 gagtcgcgat ccgaaatgtg gcaggagaga tgcttggttc catgactgca gtaaactggg
    10921 ccatagaaaa caaatatcca gctgtggaaa tccgctatga ttacgaaggt gtagagaagt
    10981 gggtaacagg tgtgtggaga gccaaaatac cactgaccag caaatacgta gcctatatgc
    11041 aggaagcagg aaagaaagta aagatttctt tttgtaaaat agcagcccat acgggcaatc
    11101 actacaatga agaggcagac cagctggcta agagtgcgtt gcttaaggcg gatgaagaag
    11161 tacgaatata aaagttcata ttaaagaaag taagtatctg aaaagtagaa aaatatgtga
    11221 taaaaacacc tgcttgttga tagctgataa aatatatcag catcaatagc aggtgtttta
    11281 gggataagat tgaataattg tgaatctgcc atctgatgag aatacaaatt catcttaaca
    11341 gagttatttc aagtgtttta tcctgttttc actggtattg gaccacatag tatattgttt
    11401 acaatttcta aaatgcttat cacagtaaga attgaaagaa gtttggctta catttttcat
    11461 atgctgttca tctttaccgg tttgaaaacc agcaacagaa cagtatgccc ttgatgtact
    11521 gacaagttta gaaccggaca aagtccataa tgcagaaccg gaaccaccta ctccgttggt
    11581 ccaccagctt atatgtattc cattgtagtg agtgttatac tgtaaaattt gataattcat
    11641 cccttttccg gaacactgac cggcatagat tactttgcca ttttttatgg tatatacaga
    11701 ataatctaca ataactccac ggttgcttga tacaatcaga tcaggggttc catttctgtc
    11761 aatatccatt agatagaaac attttccgcc agattggagc agaacctttt catataaggc
    11821 tctttgatct tttattttaa tctgacattt cagtttttta gagccgattt tggctgtaat
    11881 tgttgcggta cctgttttct ttgcttttac ttttccagaa gaaacagatg caactttact
    11941 gtcagtgctg gaccaggtaa cttttttgtt tgtcccgctt accttgaggt gataaacacc
    12001 accaacattc attgtcagtt tagttttatt cagttttacg gaagctgcct gagcagtacg
    12061 tggaattatt attagagaaa taaccattaa tac
//
