LOCUS       c00010_gnlPro..        15420 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AKOCODOI_10.
ACCESSION   c00010_gnlPro..
VERSION     c00010_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 17:50:23
            Original ID  :: gnl|Prokka|AKOCODOI_10
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15420
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15420
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[97:5420]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      98..5420
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15420
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15420
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             98..1534
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg10_1"
                     /sec_met_domain="CT_Vparvula (E-value: 3.2e-136, bitscore:
                     445.7, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNATQSLAGTRITSLLDANSFVEIGQGVTARSTDFNMTANKAPS
                     DGVITGYGVIDDKLVYVYSQDASVLNGTVGEMHAKKITRLYDLAMKTGAPVIGLVDCAG
                     IRLQEATDALEAFGQIYLKQTLASGVIPQITAIFGTCGGGMAVIPSLTDFTFMESKKGK
                     MFVNTPNALEGNNTDKCDTAAADFQSKETGVIDGVGTEDEILGQIRSLVSLLPSNNEDT
                     DNYTECTDDLNRVCADLANCAGDTAIALSQIADNGEFFETKADYAKDMVTGFIRLNGAT
                     VGAVANRSEVYDAEGKKTETFDGSISARGARKAADFVKFCDAFDIPVLTLTNATGFMAT
                     LCSEKMMAKSVGELVAAFADATVPKVNVIIGKAYGTAYVAMNSKSIGADLVYAWDNAEI
                     GMMDASLAAKIMYADADAAELNEKAAQYRELQNGVASAAARGYVDTVISPADTRKYVIG
                     AFEMLFTKREDRPSKKHGTV"
     CDS             1582..2304
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg10_2"
                     /sec_met_domain="OAD_gamma (E-value: 2.7e-27, bitscore:
                     86.3, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFLVMAALVIGSTSVVFAADKVDDTVKSTLVTTAEGLTDAIVQL
                     KDEEIENYMSSGDDFTTSAMQSWQTSKDELGAKKDSNGETTVTFKDDQYTVTVPLKFEK
                     AEANFVYVFDSQGTPTSMSVDVQYGMGKTLQRAGLNTLMGIGTVFVMLILLSLLISLFR
                     FIPNPEAKKAAEAKAAKAAKEAEAAAIAQAAPAQAEENLADDGELVAVIAAAIAAAEGT
                     TTDGFVVRSIRKVKRNRR"
     CDS             2332..2700
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63.1; E-value:
                     5.3e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg10_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.6e-20, bitscore:
                     63.1, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGTAYEVTVEETGSVSAPAAAPKAAPKAAPAAAPKAA
                     APAAGAGAVKVTASVPGKVVKVAASVGQAVKAGDSVIILESMKMEIPVVAPQDGTIASI
                     DVAEGASVENGDTLATMN"
     CDS             2717..3865
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg10_4"
                     /sec_met_domain="OAD_beta (E-value: 1.3e-156, bitscore:
                     511.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVTETLSNLIHQTAFFNLTWGNYLMIAVACVFLYLAIKKGFEP
                     LLLVPIAFGMLLVNIYPDIMANPEDMSNGVGGLLHYFYILDEWSILPSLIFMGVGAMTD
                     FGPLIANPISFLMGAAAQLGIYAAYFLAIFLGFNGKAAAAISIIGGADGPTSIFLAGKL
                     GQSALMGPIAVAAYSYMSLVPIIQPPIMKLCTTEKERKIKMDQLRPVSKLEKILFPIVI
                     TIVVCLILPTTAPLVGMLMLGNLFRECGVVKQLTETASNALMYIVVILLGTSVGASTSA
                     EAFLNADTLKIVVLGLVAFAIGTFGGCMLGKLLCKLTHGKINPLIGSAGVSAVPMAARV
                     SQKVGAEADPTNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             4008..5420
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg10_5"
                     /sec_met_domain="HMGL-like (E-value: 1.1e-46, bitscore:
                     150.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 1.2e-58, bitscore:
                     189.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELEKKPVKIVETILRDAHQSQIATRMTTEQMLPIVDKLDKVGY
                     HAVECWGGATFDASLRFLHEDPWERLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSAANGIDIIRIFDCLNDLRNLQTAVSAANKEKAHAQVALSYTLGDAYTLEYWTD
                     IAKRIEDMGADSICIKDMAGLLLPNKATELVTALKETVKIPIDLHTHYTSGVASMTYLK
                     AVEAGVDIIDTAMSPFALGTSQPATEVMVETFKDTPYDTGFDQKLLSEIADYFRPIRDE
                     ALDSGLLNPKNLGVNIKTLLYQVPGGMLSNLTSQLKEQHAEDKFYDVLEEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKMVTKETKDILLGKYGATVKPFNPEVQKKCIGD
                     EKPITCRPADLLDNELEKLESEMAQYKEQDEDVLTYALFPQVAMDFFKYRQAQKTKVDE
                     KAADKKNGAYPV"
     CDS             5535..7001
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg10_6"
                     /sec_met_domain="HI0933_like (E-value: 2.8e-128, bitscore:
                     419.0, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVVHIYIDRSEAETWNYDEIDNLQGKINTGEYSMSKVIIIGGGA
                     AGMMAGVFAARNHHEVHILEKNEKLGKKVFITGKGRCNVTNACDTEELFPAMMSNPKFL
                     YSSFYSFTPQDVMEFFEKAGVPLKVERGNRVFPQSDHSSDIIRALERELKKAGAKIHLH
                     TAVQEIVKKPVTDSANTLESEATLTESGSDAGKGRKGKKSPDIPQEKITGVILTDGTFM
                     EGDAVIVATGGFSYQSTGSTGDGYRFARELGLKVTDIAPSLVPLKTKEDYIPKLQGLSL
                     KNTGLTIKNGKKVLYEDFGEMMFTHFGVTGPMILSASAHIGAKLAKAPNGELSAYLDLK
                     PALTREQLDARILREFEAGPNKQFKNVIGVLFPSSLTPVMLELGGIPAEKKIHDISREE
                     RQHFIDLIKAFPFTITGMGEFKEAIITRGGVSVKEINPGTMESKKISGLYFAGEVLDLD
                     AVTGGYNLQIAWSTAYLAAQAIRYCSLRSQ"
     CDS             7164..7835
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytidylate_kin"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg10_7"
                     /sec_met_domain="Cytidylate_kin (E-value: 7.7e-78,
                     bitscore: 252.0, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGCNIAIDGPAGAGKSTIAKKVAKELSFIYVDTGAMYRAMALYLL
                     NHGVNGENQEEIEAVCSGADISIEYKNGEQIVILNGENVNAMIRTEQVGNMASKSSANP
                     KVRAHLLKLQRTLAEKNDVVMDGRDIGTTILPNAEVKIYLTASADTRAKRRALEYEQKG
                     ESFDLDQIRKDIIERDERDMNREISPLKQADDAVLVDSSEMGIDDVVNAILNVYKEKVQ
                     K"
     CDS             7854..8732
                     /locus_tag="ctg10_8"
                     /transl_table=11
                     /translation="MKVKVAETAGFCFGVKRAVNKVYELIDTEQKPIFTLGPIIHNEGV
                     VADLEARGVHVIAEADLDSPDDTLQNGTVVIRSHGVGKAIYDKLKEKNISYVDVTCPFV
                     LKIHRIVEKESLAGNHIIIIGDKDHPEVQGICGWCQGPYTVIRNKEEAEAFVPPKGKKI
                     SIVSQTTFNYNKFKDLVEILCKKRYDNNVLNILNILNTICNATEERQREAKNIAGEVDT
                     MLVVGGRHSSNTQKLFEICKKECGNTYYIQTPVDLDSEMFQCSSYVGITAGASTPNKII
                     EEVQEHVRIKF"
     CDS             8713..9789
                     /locus_tag="ctg10_9"
                     /transl_table=11
                     /translation="MSELSFEQMLEDSVKTIRNGEIVQGTVIDVKEDEIILNIGYKADG
                     IITKNEYSNDASLVLTDAVHVGDTMEAKVLKVNDGEGQVTLTYKRLAAEKGNKRLEEAF
                     ENQEVLKAPVTQVLDGGLCVNVDEARVFIPASLVSDTYEKDLSKYADQEIEFVITEFNP
                     RRRRIIGNRKQLLLAEKAEKQKELMERIHVGDTVEGTVKNVTDFGAFIDLGGADGLLHI
                     SEMSWGRVENPKKVFTVGDKVKVLIKEINGEKIALSLKFPEANPWLTAAEDFAVGNVVK
                     GKVARMTDFGAFVELAPGVDALLHVSQISREHVAKPADVLSIGQEIEAKVVDFNGEDKK
                     ISLSMKALEAPAEEATEE"
     CDS             9889..10662
                     /locus_tag="ctg10_10"
                     /transl_table=11
                     /translation="MTDHGLFDIHCHLIPGVDDGAQDLEETRRLLRMEYEQGVRNIIAT
                     PHYRDQMFDTPIRTIRSQFALVEKCVQEFNQELAKEDRMRIYLGCEFHANMQMSRMLDE
                     GRVSTMADSGYVLVEFSGNAEYSYIEDRLRSLIIVGYRPIIAHVERCDNIWGDLELIRD
                     LAQMGAYMQVNADSILGKSGFYTKRFCRKLMKGDLLHFVGSDCHDSRYRICRTGEAYKK
                     VISKMGQEYADKIFIENPSTIVKNGENRRKFVKYT"
     CDS             10891..11493
                     /locus_tag="ctg10_11"
                     /transl_table=11
                     /translation="MLITAMLAGVYYLVGVKPSYQADASIFITNNESVITVSDLQLSSE
                     LTEDYAKIIKSRNVLKQVIKELDLDLDYRGLSKLVSVTNPDNSHIITITVTCGDVELCR
                     DIANSLMNIGLDRIYQVVGSSEPTVIDYSEAEAVDEITPALTKYLAIGLLLGLIAACGL
                     ICVRYMTDTTLKTEDDLKRYLDIPVLSVIPYYEEKKE"
     CDS             11497..12306
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CbiA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg10_12"
                     /sec_met_domain="CbiA (E-value: 2e-08, bitscore: 25.3,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDREDNNIESLFQDLVKESGYTGRQTEVIHPHVSDVSFRVNEAIN
                     VLRGNIQLSGSNIKTIAVTSSVANEGKSSIAFRLAKSMAGLEKRILFIDCDIRNSTIQN
                     RYDIVGEKKGLSEYLCGNISKEKIIYRTDDKYLDMIFTGAVAPNPSELVSGPLFAELME
                     FVRSVYDYVIVDTPPLNLVIDGLLIAKQCDGTVLVVESGKTDRAQADKAKQQIQYAGIR
                     LLGAVLNKAPVYEKHYGYGYGYGYGYGYGYGYGYGKSAKKNGKEKKK"
     CDS             complement(12275..12712)
                     /locus_tag="ctg10_13"
                     /transl_table=11
                     /translation="VCGIESLVIAVHCISSDISHGITVNGENSHPAILLIHHHQSNTVC
                     PGFISILGGSFQLACGVHTGIENICDTVIILIFLTFVNNISITVAHIVGVPCSDLHRFL
                     LCLFHMDKNCCKQSYSQADHQTDDDLFLIYRVISSFLFHSS"
     CDS             12803..13306
                     /locus_tag="ctg10_14"
                     /transl_table=11
                     /translation="VKRYVVTNQDSMPYINELAGGITLTVPNNDLQEKYPEMAEGAQVT
                     LDDSNIKDFLQYRNTEESFSNEGRMQRQKAYLTAYVEKMQSMDENDLEKAWDSLDVMDD
                     YIQTSVTRNQYLGLVKTLKKAEFTEDSIEQLPGTDQEGDLHDEFHVDEDALRELIIRLF
                     YEKI"
     CDS             13396..14646
                     /locus_tag="ctg10_15"
                     /transl_table=11
                     /translation="MKRKYFSILLAAMTIAASANVYAAPSIGQIIPEAPKVVEGNLSNK
                     QELIVKDVDTGAYKDKKVAEVVTKVNDDNTKVTMNEILKDLKVDTTETIKTNTEKKVNP
                     SLYEPLTPFVDLVIKEDDKITYETNGAIKTTLTIEAAKDVKKKDVLLMQIDPTTGKVAF
                     VAIEKLDKATGEVTATFDSLGPVMLIEKVPVVTKKVSPEKYADKKVADAAEKLKDQKAG
                     FTLTDFIDDLTDTENKEVTLDNGQTINLDDYVSASSLIDMAIKMSDDYSYDMSGSLDAQ
                     VNCDIDSVDWKSLVTANDADFDVDTAEGDLSLLTEIEPFTIPDSIVVQADASTGELNYL
                     AEPELSFAYPEKEEEEAEAADDADETADTDETADAEDDLMNWIVKDEAGSSEQPNLVIK
                     GEFKGMGPLAIFTKDAK"
     CDS             14670..14933
                     /locus_tag="ctg10_16"
                     /transl_table=11
                     /translation="MSRKSRRRRHKKNKFMSSVLYYVLVIALVAGLLFVVKVNRQERAE
                     RTEYKEKLAGKETEEDIGVLDDMMVRPTAEPTETPTDTAADK"
ORIGIN
        1 aatgttgaaa ttttctgccg aaaaaggtaa aattaaaatc ggctaaattt ttgggttaac
       61 ttttaaatat tctcatacag atggagggca aacaagaatg agtaatgcaa cacaaagctt
      121 agcaggcaca agaattactt ctttgcttga cgcaaacagt tttgtcgaaa tcggacaggg
      181 tgtaacagcc agatccacag atttcaacat gactgcaaac aaggcaccat ctgacggtgt
      241 tatcaccgga tatggtgtga tcgatgacaa actggtttat gtatacagcc aggatgcatc
      301 tgtattaaac ggtactgttg gtgaaatgca tgcaaagaag atcacaagac tttatgatct
      361 tgccatgaaa acaggcgctc cggttatcgg acttgttgac tgtgcaggta tccgtcttca
      421 ggaagcaaca gacgcactgg aagctttcgg acagatttat ctgaaacaga cactggcatc
      481 cggtgtgatc ccgcagatca cagcaatctt cggaacatgc ggcggtggta tggcagttat
      541 cccgtccctg acagatttca cattcatgga atccaaaaaa ggaaaaatgt tcgtcaacac
      601 accaaacgca ctggaaggaa acaacacaga caaatgcgac acagcagcag ctgatttcca
      661 gagcaaagag acaggtgtga tcgatggcgt tggtacagag gatgagattc ttggccagat
      721 ccgttcctta gtatcacttc ttccttctaa taatgaagac acagacaatt acacagagtg
      781 tacagatgat cttaaccgcg tatgcgcaga tcttgcaaac tgtgcaggtg acacagcaat
      841 cgcactttcc cagatcgctg acaacggtga attcttcgag acaaaagcag actatgcaaa
      901 agacatggtt acaggcttta tccgtttaaa cggcgctaca gtaggtgctg ttgcaaacag
      961 aagcgaagta tatgacgcag aaggcaagaa aacagaaaca tttgacggaa gcatctctgc
     1021 aagaggcgca agaaaagcag cagatttcgt gaaattctgc gacgcttttg atattccggt
     1081 acttacactt acaaacgcaa caggcttcat ggcaacctta tgcagcgaga agatgatggc
     1141 gaaatccgta ggtgaactgg tagctgcatt cgcagatgca actgttccga aggtaaatgt
     1201 gatcatcggc aaagcttacg gtacagctta cgtggcaatg aacagcaaat ctatcggtgc
     1261 agaccttgta tatgcatggg ataacgcaga gatcggtatg atggatgctt ccctggcagc
     1321 caagatcatg tacgcagatg cagatgctgc tgaactgaat gaaaaagctg ctcagtacag
     1381 agagcttcag aatggtgttg cttccgcagc agcaagaggc tatgttgaca ctgtgatcag
     1441 cccggctgac acaagaaaat atgtaatcgg tgcatttgag atgctgttca caaagagaga
     1501 agatcgtccg tctaagaaac atggaacggt ctaagcgggg tgacgcatat gaaaatgatc
     1561 aaaaaaataa cttctgtatt catgacattt ctcgtaatgg ctgcgctggt gatcggcagc
     1621 acctctgtgg tatttgccgc agataaggtt gatgatactg ttaagtccac actggtaact
     1681 acagcagaag gactgacaga tgccattgtc cagcttaagg atgaagaaat cgagaattac
     1741 atgagttcag gagatgactt tacaacaagt gccatgcagt cctggcagac atccaaggat
     1801 gaacttggcg caaagaagga cagcaatggt gaaactactg taactttcaa agatgatcag
     1861 tacacagtta ctgttcctct taaatttgag aaagcagaag caaactttgt atatgtcttt
     1921 gactcacagg gaacaccgac ttccatgtct gtagatgtac agtatggtat gggcaagact
     1981 cttcagagag caggtcttaa tactctgatg ggtattggaa ctgtattcgt aatgctgatt
     2041 ttattaagcc ttctgatttc tctgtttaga tttattccga atccggaagc aaagaaagca
     2101 gcagaagcaa aagctgccaa agctgcaaaa gaggcagagg cagcagccat cgcacaggca
     2161 gcacctgcac aggcagaaga gaaccttgca gatgacggag agctggtagc tgttattgca
     2221 gcagccatcg cagcagcaga aggaactaca acagatggct tcgtagttcg ttccatccgt
     2281 aaagtaaaaa gaaatagaag ataattgtta tttatttagg aggattttaa aatgaaaagc
     2341 tatacaatta cagtaaacgg aacagcatat gaagtaactg ttgaagaaac aggaagcgta
     2401 tccgctcctg cagcagctcc aaaagcagca cctaaggctg cacctgcagc agctccgaaa
     2461 gcagcagcac ctgcagcagg cgccggcgca gtgaaagtaa ctgcttccgt acctggcaaa
     2521 gttgtcaaag tagcagcaag cgttggacag gcagtaaaag ccggagacag cgtaattatt
     2581 cttgaatcca tgaaaatgga aatccctgta gtagctcctc aggacggtac tatcgcaagc
     2641 attgatgttg cagaaggtgc ctctgtagaa aacggagata ctttagcaac aatgaactaa
     2701 gacgggaggt agtcaaatgt cttatgtaac agaaacattg tccaacctga ttcatcagac
     2761 agcattcttt aatctgacat ggggcaatta cctgatgatc gcagtagcct gcgtattcct
     2821 ttaccttgct atcaagaagg gattcgagcc gcttctgctt gttcctatcg cattcggtat
     2881 gctgcttgta aatatctatc cggacattat ggcaaatccg gaagatatgt ccaatggtgt
     2941 aggtggactt cttcattatt tctacatcct tgatgagtgg agtatcttac catccctgat
     3001 cttcatgggt gtaggtgcca tgacagactt cggtccgctg atcgcaaacc cgatcagctt
     3061 cctgatgggt gctgcggcac agcttggtat ctatgcagct tacttccttg caatctttct
     3121 tggattcaat ggaaaagcag cagcagcaat ctccatcatc ggtggtgctg acggcccgac
     3181 ttccattttc cttgcaggta aacttggaca gtctgcactg atgggaccga tcgcagtggc
     3241 agcatattcc tatatgtcac tggttccaat catccagccg cctatcatga aactctgcac
     3301 aacagagaaa gaacgtaaga tcaaaatgga tcagcttcgc ccggtttcca aactggagaa
     3361 gatcctgttc ccgatcgtta tcacaatcgt tgtctgcctg attttgccta caacagctcc
     3421 gctggttggt atgctcatgc ttggtaacct gttcagagag tgcggtgttg taaaacagct
     3481 gacagaaaca gcttccaatg ccctgatgta tatcgtagtt atccttctgg gtacatccgt
     3541 aggtgcttcc acaagtgcag aagcattctt aaacgcagat actctgaaga tcgtagtttt
     3601 aggtcttgtt gcattcgcaa tcggtacatt cggcggatgt atgcttggta aactgctctg
     3661 caaactgact catggaaaga tcaacccgct gatcggttcc gcaggtgtat ccgcagtacc
     3721 tatggcagcc cgtgtatccc agaaagtggg tgcagaggca gatcctacaa acttccttct
     3781 gatgcacgca atgggcccga acgttgccgg tgttatcggt acagccgtag cagccggaac
     3841 atttatggct attttcggag tataaccaaa tcaagcaagc tatcttgctt gtatcaggag
     3901 gagtgcaact ccttctgata agctgcggag cagctatttg gttatgagca agtagcgaag
     3961 cggattgcga atatccgatt aaacagaact ataaaggaga tttaataatg gcagaattag
     4021 agaaaaaacc tgttaaaatt gtggaaacca ttctccgtga tgctcatcag tcccagattg
     4081 caacacgtat gaccacagaa cagatgcttc cgatcgtaga taaacttgat aaagtcggct
     4141 atcacgcagt agagtgctgg ggtggtgcaa cattcgatgc atcccttcgt ttccttcacg
     4201 aagatccatg ggaaagactt cgtaaattac gtgacggctt caagaacaca aaacttcaga
     4261 tgcttttccg tggacagaac atccttggat accgtccata cgcagatgac gttgtagaat
     4321 acttcgtaca gaaatctgca gcaaacggaa tcgacatcat ccgtattttt gactgcctca
     4381 atgaccttcg taacctgcag acagcagtaa gcgctgcaaa caaagagaag gctcatgcac
     4441 aggtagctct ttcctacaca ttaggagatg cttacacact ggaatactgg acagacattg
     4501 caaaacgtat cgaagatatg ggcgctgatt ccatctgtat caaagatatg gcaggtcttc
     4561 tccttccaaa caaagctaca gagcttgtaa cagcattaaa agaaacagtt aagatcccga
     4621 tcgaccttca tacacattac acctcaggtg tagcttccat gacttactta aaagcagtag
     4681 aagcaggtgt ggatatcatc gatacagcaa tgtctccatt tgcactggga acatcccagc
     4741 ctgcaacaga ggttatggtt gagacattca aggatacacc atacgacaca ggatttgatc
     4801 agaagcttct ctccgagatc gctgactact tccgtccgat ccgtgacgaa gctcttgaca
     4861 gcggactgct caatccgaag aaccttggtg ttaacatcaa aactttactg taccaggtac
     4921 cgggcggtat gctctccaac ctgacttccc agctgaaaga acagcacgca gaagacaaat
     4981 tctacgatgt tctcgaggaa gttccgcgtg tacgtaaaga ccttggtgaa ccgccgcttg
     5041 ttactccgtc ttcccagatc gttggtacac aggctgtatt caacgtactt atgggcgaga
     5101 gatacaaaat ggttacaaaa gaaacaaaag atatcctgtt aggaaaatac ggcgcaactg
     5161 taaaaccgtt taatccggaa gtacagaaga agtgtatcgg cgatgagaaa ccgatcacat
     5221 gccgtccggc agaccttctt gacaacgagc ttgagaaact tgagagcgaa atggctcagt
     5281 acaaggaaca ggatgaagac gtattaacat acgcactgtt cccacaggta gctatggact
     5341 tcttcaaata ccgtcaggct cagaaaacaa aagttgacga gaaagcagct gacaaaaaga
     5401 acggagcata tcctgtataa ttgatcagta attaaatatg tccaaacgaa aaaaggagct
     5461 tgcgtaagca ggctcctttg cgttattatg aaagaatatg atacccggga atataatgtg
     5521 ccaatgggga tatgatgcca gtggtacata tctatattga tcgtagcgaa gcggagacgt
     5581 ggaactatga tgaaatagac aatctgcagg gtaaaataaa tacaggagaa tattccatga
     5641 gcaaagttat aataatcggc ggcggagccg ccggaatgat ggcaggggtt tttgcggccc
     5701 gtaaccatca tgaagttcat atattagaga agaacgagaa actgggaaag aaagtcttca
     5761 tcacaggaaa aggcagatgc aatgtgacaa atgcctgcga cacagaagaa ctctttcctg
     5821 caatgatgag caatcccaag ttcctctaca gcagtttcta ttcatttacc cctcaggatg
     5881 taatggagtt ctttgagaaa gcaggtgtcc ctctgaaggt agagcgtgga aacagagtat
     5941 tcccacagtc tgaccattcc tcagacatca tccgcgctct ggagcgtgag ctgaagaaag
     6001 caggagcaaa gattcatctt cacactgctg tacaggaaat cgtaaagaaa cctgtaacag
     6061 attcggcaaa taccctggaa tcagaagcta cattaacaga atcaggatct gatgcaggaa
     6121 aaggcagaaa aggaaaaaaa tcacctgaca taccgcagga gaagatcaca ggagtcatcc
     6181 ttacagacgg aaccttcatg gaaggcgatg cagtcatcgt ggcaactggc ggattctctt
     6241 atcagagcac cggctcaaca ggcgatggat accgctttgc aagagaactt ggattgaagg
     6301 tcacagacat tgcaccttct cttgtcccat taaagacaaa agaagactat atccctaagc
     6361 ttcagggact ttcccttaag aatacaggac ttaccataaa gaatggaaag aaagtactct
     6421 atgaggattt cggagagatg atgttcaccc atttcggagt cacaggtccc atgatcctct
     6481 ccgccagtgc tcatataggt gcaaaactgg cgaaagcacc aaacggcgaa ctgtccgcat
     6541 atctggatct gaagcctgca ctcaccagag aacaactgga tgccaggatc ctgcgtgaat
     6601 ttgaagcagg accaaacaaa cagttcaaga atgtgattgg tgtacttttt ccgtcatctc
     6661 tgactccggt aatgctggaa ctgggtggaa tccccgcaga gaagaaaatc cacgatatct
     6721 ccagagaaga acgccagcac ttcattgacc ttatcaaagc cttccccttc acaatcacag
     6781 gaatgggtga gttcaaagaa gccatcatca ccagaggcgg cgtctctgtc aaagagatca
     6841 accccggaac aatggaatca aagaaaatct caggtcttta cttcgcaggc gaagtgctgg
     6901 atctggatgc agtgacaggt ggatataact tacagattgc ctggtctacc gcatatctgg
     6961 cagcgcaggc tatacgttac tgttcactcc gttcacagta acggctatac agtaagctga
     7021 aaaaagcgga tgatgagtac cttgtaggtg gatgatatct atgatatgat tcagctatac
     7081 gttatttaac gatttataaa catcaatcaa taataaaaca gagaaaatct gtttgaataa
     7141 tagaaacagg aggaaccacg aaaatgggat gcaatatagc catcgacgga cctgcaggag
     7201 caggtaagag taccatcgca aagaaagtag caaaagaatt atcatttatc tatgtagata
     7261 caggagccat gtacagggca atggctttat atcttttgaa ccatggcgta aacggagaaa
     7321 atcaggaaga gatcgaggct gtatgttccg gcgctgacat ctccatcgaa tacaaaaacg
     7381 gagaacagat tgtcatcctc aacggagaga acgtaaatgc tatgatccgc accgaacagg
     7441 taggaaacat ggcatccaaa agttccgcaa acccgaaagt cagagcccat cttctgaaac
     7501 ttcagagaac tctggcagag aaaaacgacg tagtcatgga cggcagagat atcggcacaa
     7561 ccatccttcc aaacgcagaa gtaaaaatct acctcacagc aagcgcagac accagagcaa
     7621 aaagaagagc actggaatat gaacagaagg gagaatcctt cgacttggac cagatccgaa
     7681 aagacatcat cgagcgcgac gaacgcgaca tgaaccgcga aatctcccct ctgaaacagg
     7741 cagacgacgc agtgcttgta gattcttcgg aaatgggaat tgatgatgtt gtaaatgcga
     7801 ttcttaatgt atataaggaa aaagtgcaga aataatttaa gaaggattat tttatgaaag
     7861 taaaagtagc agaaacagca ggcttctgct tcggcgtcaa acgtgcagtg aacaaagtct
     7921 acgaactcat agacacagaa cagaaaccta ttttcactct gggcccgatc atccacaacg
     7981 aaggcgtagt agcggatctg gaagctcgtg gcgtccatgt tatcgcagaa gcggatctgg
     8041 attccccgga tgacaccctg cagaacggaa cagtagtcat ccgctctcac ggtgtaggca
     8101 aagccatcta cgataagctg aaagaaaaaa acatctctta tgtagatgtg acctgcccct
     8161 tcgttctgaa aatccacagg atcgtggaaa aagaaagcct tgcaggaaac cacatcatca
     8221 tcatcggcga caaagaccac cctgaagtac agggcatctg cggctggtgt cagggaccgt
     8281 acacggtgat cagaaacaaa gaagaagccg aagcatttgt acccccaaaa ggcaaaaaaa
     8341 taagcattgt gtcccagacg acatttaatt acaacaaatt taaagattta gttgaaattc
     8401 tttgcaaaaa gaggtatgat aataatgttt taaatattct caatatttta aacactattt
     8461 gtaatgctac cgaagaacgg cagagagaag caaaaaacat agccggagag gtagacacta
     8521 tgttggtcgt aggtggccgg cacagttcca atactcaaaa gctgtttgaa atatgtaaaa
     8581 aggaatgtgg aaatacttac tatatacaaa cacctgtaga cttggattct gaaatgttcc
     8641 aatgcagtag ttatgtaggt attacagcag gggcttccac cccaaacaaa attattgagg
     8701 aggttcaaga acatgtcaga attaagtttt gaacaaatgc tggaagattc cgtaaagact
     8761 atcagaaatg gagagattgt acagggtact gtcatcgatg ttaaagaaga tgagattatt
     8821 ctgaatatcg gttataaagc agacggtatt atcacaaaga acgaatactc taacgatgca
     8881 agccttgtac tcacagatgc tgttcacgtt ggagacacaa tggaagcaaa agttctcaaa
     8941 gtaaacgatg gagaaggtca ggttactctt acttacaaga gactggcagc agagaaaggc
     9001 aacaaacgtc ttgaagaagc atttgagaat caggaagtat taaaagctcc tgtaactcag
     9061 gtacttgacg gcggactttg tgtaaacgta gacgaagcaa gagtattcat tcctgcaagt
     9121 ctcgtttccg acacatacga gaaagacctt tccaaatatg cagatcagga gatcgaattc
     9181 gttatcacag aattcaaccc gagaagacgc cgcatcatcg gtaaccgtaa acagcttctt
     9241 ctcgctgaga aagcagagaa acagaaagaa ttaatggaga gaatccatgt tggcgacaca
     9301 gttgaaggaa cagttaagaa cgttacagat ttcggtgcat tcatcgatct gggcggagct
     9361 gacggacttc ttcacatttc cgaaatgtcc tggggcagag tagagaaccc gaagaaagta
     9421 ttcactgttg gcgataaagt caaagttctt atcaaagaga tcaacggaga gaagatcgca
     9481 ctttccctta aattcccgga agcaaatcca tggctcacag cagctgagga cttcgctgta
     9541 ggaaacgtag ttaaaggtaa agttgcacgt atgacagact tcggtgcatt cgtagagctt
     9601 gcacctggag tagatgcact ccttcacgta tcccagattt ccagagagca cgttgctaaa
     9661 cctgcagacg tactgtcaat tggacaggag atcgaagcta aggttgttga cttcaacggc
     9721 gaagacaaga agatcagcct gagcatgaaa gctcttgagg caccggctga ggaagctaca
     9781 gaagaataat ttatcataat catgatgttc agacaccgtc cctgtataag tttatatagg
     9841 gacggtgttt ttgcagttat ttgcaataaa gggagatgaa agagaaatat gacagaccac
     9901 ggtttatttg atatccactg ccacctgatt ccgggagtgg acgacggagc acaggacctg
     9961 gaggaaaccc gcagactgct ccgcatggaa tatgaacagg gagttagaaa cattatcgca
    10021 acccctcatt acagagatca gatgtttgat acacccatcc gcaccatccg cagccagttc
    10081 gctctggtgg agaaatgcgt acaggaattc aatcaggagc ttgctaagga agacagaatg
    10141 agaatatacc tgggctgtga attccatgca aacatgcaga tgagcagaat gctggatgag
    10201 ggaagagtca gtacaatggc agattccggc tatgttctgg tagaattctc aggaaatgca
    10261 gaatacagct acatagaaga ccgtctccgc agccttatca tcgtaggcta ccgtcccatc
    10321 atcgcacatg tagaacgctg cgacaacatc tggggtgacc tggaactgat cagggacctt
    10381 gcacagatgg gcgcctatat gcaggtaaat gcagatagca ttctgggaaa aagcggattc
    10441 tatacaaaaa gattctgcag gaagctgatg aaaggagacc tccttcactt cgtaggctct
    10501 gactgccacg acagtcggta caggatctgc cgcacaggag aagcatacaa aaaagtcatc
    10561 agcaaaatgg gacaggaata tgctgacaaa atttttattg aaaatccttc cacaattgta
    10621 aaaaatgggg aaaacagaag aaaatttgtc aaatacactt gaagaacgtc agaaatcata
    10681 ttacaatcta taaagtacgg accggcctgt aactccggtt tgatcatata aggaaggaga
    10741 atcaagaatt tgataaaaga ggcaaagaat acccgggaaa atcctgcgca gcctgtggtc
    10801 actgagacga tcatacagca ggaagacacc atagaccttg tggaactttt ctgggtactg
    10861 gtcaatcatt ggaaaattat tctgctgacc atgctgatca cagcaatgct ggcaggtgtc
    10921 tattatctgg tgggggtgaa accatcttat caggcggatg catccatttt tatcacaaac
    10981 aatgaatccg tgatcacagt ttctgacctg cagctgagtt cagagcttac agaggactat
    11041 gcgaagatca tcaagagccg taatgttctc aaacaggtca tcaaagagct ggatctggat
    11101 ctggattaca gaggactcag taaactggtc agtgtaacga atccggacaa ttcccatatt
    11161 attaccatca cagttacctg cggtgacgtg gaactgtgca gagatattgc aaacagtctg
    11221 atgaatatcg gactggatcg tatttaccag gtggtaggaa gcagcgaacc tacagttatc
    11281 gattactcag aggcagaggc agtggatgag atcactcctg cactgacaaa atatctggcg
    11341 attggacttc tgctgggact tatcgcagcc tgtggactga tctgcgtacg ttacatgaca
    11401 gacactacat taaagacaga ggatgacctg aagagatatc tggatatccc ggtacttagt
    11461 gtgattcctt attacgaaga gaagaaagag tagaagatgg acagagaaga taacaatatt
    11521 gaatccctgt ttcaggatct tgtgaaagaa tccggatata cgggaagaca gacagaggta
    11581 atacatccac atgtatcaga tgtatctttc cgcgtaaatg aggccattaa tgttctgcgt
    11641 ggaaacatcc agttaagtgg aagcaatatt aaaacaatag ctgtaacaag ctccgttgct
    11701 aatgagggta aatcatcaat agccttccgc ctggcaaaga gcatggcagg gcttgagaag
    11761 aggatcctct ttatagactg cgatatccgt aattctacca tacagaacag atatgatatt
    11821 gtaggtgaga agaagggatt aagcgaatac ctgtgcggaa atatcagcaa agagaagatc
    11881 atctaccgca cagatgacaa ataccttgac atgatcttta caggtgcagt ggcaccaaac
    11941 ccaagtgagc tggtatcagg tccgctattt gcagagctga tggaattcgt gcgaagcgtt
    12001 tatgattatg tgatcgtaga cactccgccg ctgaatctgg ttatcgacgg gctgttgatc
    12061 gccaagcagt gcgacggaac tgtccttgtt gtggagagcg gaaagacaga cagggcacag
    12121 gctgataagg cgaagcagca gatacaatat gcaggtatcc gtctcctcgg cgcagtgctg
    12181 aacaaagcgc cggtttatga gaaacattat ggctatggat atggctacgg ttatggttac
    12241 ggctatggct acggatacgg ctatggaaag agcgctaaga agaatggaaa agaaaagaag
    12301 aaataaccct gtaaataaga aacagatcat catcagtctg gtgatctgcc tggctgtagc
    12361 tttgtttgca gcagttttta tccatatgga acagacaaag cagaaatcta tgcagatcac
    12421 tgcagggaac acccacaatg tgggcaacag ttatagaaat attgtttaca aaggtcagga
    12481 atatcagtat aataaccgta tcacaaatat tctctatgcc ggtgtggact ccacaggcaa
    12541 gctggaagct tcctcccagt atggaaataa agccagggca gacagtattg ctctggtggt
    12601 gatggatgag aagaatcgca ggatgactat tctctccatt aaccgtgata ccatgactga
    12661 tatccgaaga tatacaatga acggcaatga caagggactc tataccacac acatcggata
    12721 tgcctacagc tatggcgatg ggggaaaggt aagctgtgag agcctctgtg aggcagtatc
    12781 ccttttactt ggagatatcc ctgtgaagcg ctatgtagtg acaaaccagg actccatgcc
    12841 ctatatcaat gagctggcag gcgggatcac acttacagtg ccaaacaacg atcttcagga
    12901 gaaatatccg gagatggcag agggtgcaca ggttaccctg gatgacagca acataaagga
    12961 tttccttcag tacaggaata cagaggagtc cttcagcaat gagggccgta tgcagagaca
    13021 gaaagcctat ctcacagcct atgttgagaa gatgcagtcc atggatgaga atgaccttga
    13081 gaaagcatgg gattccctcg atgtgatgga cgattatatc cagacaagtg tgacacgcaa
    13141 ccagtatctg ggacttgtga agactcttaa gaaagcagag ttcacagagg acagtataga
    13201 gcagcttccg ggaacagacc aggagggaga ccttcatgat gagttccatg tggatgaaga
    13261 tgcactccgg gaactgatca tccgtttatt ttatgaaaaa atatgacagg ctgctgtttt
    13321 tcaaccgcct tgttataaag taaccgtaaa ttaataagaa tagagccaga agaagacaga
    13381 aaggaaggca ttcttatgaa aagaaaatat ttcagcattt tacttgcagc aatgacaatt
    13441 gcagcatctg ccaatgtata tgcagcccca agcatcggac agatcattcc ggaagctcca
    13501 aaggtagttg agggaaatct gtcaaacaaa caggaactga tcgtaaaaga tgttgacaca
    13561 ggtgcctaca aggataaaaa agttgcagag gtagtaacaa aagtaaatga tgataatacc
    13621 aaggtaacca tgaatgagat tctgaaagac cttaaggtag atacaacaga aacaattaaa
    13681 acaaatacag agaagaaagt aaatccgtct ctgtatgagc ctctgacacc tttcgtagat
    13741 ctggttatta aggaagatga taagatcaca tatgaaacaa atggtgctat taaaacaacc
    13801 cttaccatcg aagctgccaa ggatgtaaag aagaaagatg tacttctgat gcagatcgat
    13861 ccgacaacag gaaaggttgc ctttgttgca attgagaagt tggacaaagc cacaggcgaa
    13921 gtcacagcca ccttcgattc acttggacct gtaatgctga tagagaaggt tcctgttgta
    13981 accaagaagg tttctcctga gaaatatgca gacaaaaagg tagctgatgc ggcagagaag
    14041 ctgaaagatc agaaagcagg cttcactctg acagatttta tcgatgatct gacagataca
    14101 gagaacaaag aggtcacact ggacaacgga cagaccatca acctggatga ctatgtcagc
    14161 gcaagcagtc ttatagatat ggcaatcaag atgtcagatg attactccta tgacatgtcc
    14221 ggctctcttg atgcacaggt aaactgtgac attgatagtg ttgactggaa gagccttgta
    14281 actgctaatg atgcagactt tgatgttgat acagcagagg gcgacctgag ccttcttaca
    14341 gagatagagc cattcacaat cccggacagc attgttgtac aggcagatgc ttctacagga
    14401 gagcttaact atcttgcaga gcctgaactg agcttcgcat atccggaaaa agaagaagag
    14461 gaagctgagg cagcagacga cgcagatgag actgctgaca cagatgagac agctgatgca
    14521 gaagatgatc tgatgaactg gatcgttaag gacgaagcag gctcttctga acagccgaat
    14581 cttgtgatca aaggcgaatt caaaggcatg ggacctcttg caatcttcac aaaagatgca
    14641 aaataatctg ataagagagg aacagttcaa tgtcacgaaa atctcgcaga cgcagacata
    14701 aaaaaaataa attcatgtcc tcagtgctct actatgtact ggttattgct ctggtggcag
    14761 gccttctgtt tgttgtaaag gtaaaccgcc aggaacgtgc agaacgcaca gaatacaaag
    14821 aaaagctggc cggcaaagag acggaggaag atattggtgt actggacgac atgatggtac
    14881 gacctacagc agaacctacg gaaacaccaa ctgatacagc agcagataaa tgataaaaag
    14941 taccaaaaat tattgcatct ttttggcaat aaagctataa taacgtgtag ataagacaaa
    15001 aggtctatag tctttgaatc gtcgctttgc cgcgtttaag gatattgatt tacatatctt
    15061 gaagagaatc tgtcttgaaa tacaggcaga atggcgaagc atacccaaaa tacggaggta
    15121 agatatccaa tgtggtatgt gatgcaggtg cgaacaggca cagaagagaa catccgctgt
    15181 caatgtcagc ggctgataag cagcgatata ctaaaacgct gctttattcc ctactatcaa
    15241 cagaagaaac gatttcaagg caaatggcat atccaggaaa gaatcctctt tcccgggtat
    15301 gtctttttaa ttgccgaaaa tctggaacag ctggctgaaa acctgaggaa agtcacagga
    15361 atgaccaggc ttctgggaac aggagacgag atcatccccc tatctcagga agaagtagag
//
