LOCUS       gnlProkkaECLMCPKP_19   16385 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ECLMCPKP_19.
ACCESSION   gnlProkkaECLMCPKP_19
VERSION     gnlProkkaECLMCPKP_19
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 10:45:22
            Original ID  :: gnl|Prokka|ECLMCPKP_19
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 68880
            Orig. end    :: 85265
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16385
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10351]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10351
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..16385
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16385
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2232..3284
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_56"
                     /sec_met_domain="PF04055 (E-value: 1.2e-16, bitscore: 53.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNDMQKRPLLGLTLSELQNVVKNLGMPGFSAKQIASWLYDKKVT
                     SIDEMSNLSLKHRELLKEIYEVGAEAPVDAMRSVDGTVKYLYRAGEGHFVEAVYIPDED
                     RATLCVSSQVGCKMNCKFCMTGKQGFTANLTSNQIINQINSLPERDKLTNVVMMGMGEP
                     LDNLDEVLKALEIMTASYGYAWSPKRVTLSSVGLKKGLQRFIEESDCHLAISLHSPIPL
                     QRRELMPAEKAFSITEIVELLRNYDFSKQRRLSFEYIVFKGVNDSLPYAKELLKLLRGL
                     DCRINLIRFHAIPGVNLEGADMETMTAFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTA
                     KQEENKEELI"
     CDS             3355..4410
                     /locus_tag="ctg19_57"
                     /transl_table=11
                     /translation="MRKHLFYLSMVLVLTLFSACGGGKKGVFTPTSSGRAYEVLVVVEP
                     GLWERPAGRALFDVLDSDVPGLPQSERSFRIMYTAPSNYDATLKLIRNIIIVDVNKDLY
                     TQPKFKYARNVYAAPQSILTIQAPDEASFEKFVEENRQVIIDFFTHAEMNRQISVLKDK
                     HSDYIATKVKSQFDCDVWVPGELTSTKEGENFFWAGTNAATGDQNFVIYSYPYTDKDTF
                     TKEYFVHKRDSVMKVNIPGAREGMYMSMDSLMTDVRPISVQGDYALEARGLWRIKGDFM
                     GGPFVSHVRLDKANQRIIVSEIFIYSPDKMKRNLVRQMEASLYTLKLPGSKQEGAEIPV
                     GVTSKDTTNNK"
     CDS             4416..5513
                     /locus_tag="ctg19_58"
                     /transl_table=11
                     /translation="MEDNKIRVGITQGDINGVGYEVILKTFADPVMLELCTPIIYGSPK
                     VAAYHRKSLDLPTNFSIVNSASEAVPNRLSVVNCTDDEVKVEFSKPDVEAGKAALGALE
                     KAIEEYKEGMIDVIVTAPINKHTIQSEEFAFPGHTEYIEQKLGDGEKALMILMKDDFRV
                     ALVTGHIPVKEIAGSITKELIQEKLKIFNRSLKQDFAISAPRIAVLSLNPHAGDGGLLG
                     TEEQEIIIPAINEMAAKGMLCYGPYPADGFMGSDNFTHFDGILAMYHDQGLAPFKALAM
                     DEGVNYTAGLPVIRTSPAHGTAYDIAGKGIASEDSFRQAIYVAIDVFRNRQREKEAHAN
                     PLRKQYYEKRDDSDKLKLDSVEEDL"
     CDS             5515..6765
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 379.9; E-value:
                     3.1e-115)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg19_59"
                     /transl_table=11
                     /translation="MTKAEIQQVKLRFGIIGNNEALMRAIDIAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EANGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVEKTDVRIVAATNVNLTQAI
                     ADGRFREDLYYRLNTVPIQVPPLRERGEDVVLLFRKFASDFAEKYRMPAIQLTEDGKQV
                     LLGYSWPGNVRQLKNITEQISIIETNREINASILKGYLPEQNNMQRLPALFGVKEDKSF
                     GSEREILYQVLFDMRQDVTDLKKLVHEIMAERGTVANPAVATSAYYTPATPAVVPPVTS
                     SVPTIIHPSVKPVTPVDDDFQDTEEYVEESLSLDEVEKEMIRKALEKHHGKRKSAAQDL
                     NISERTLYRKIKEYGLD"
     CDS             6785..7276
                     /locus_tag="ctg19_60"
                     /transl_table=11
                     /translation="MLVSLLFLVNSCSMKLGLAPISSIDYTKVKTISIADFQNRAEYVY
                     APLATEFNQKMKDMFIQQTRLQLVNSGGDLEIDGEITGYNQYNESVDASGYSSKVKVTL
                     TVNVRYTNNTNHEEDFEQQFSAFQTYDSSKLLTEVQDQLITLMVKDIAEQIFNATVANW
                     "
     CDS             7281..8054
                     /locus_tag="ctg19_61"
                     /transl_table=11
                     /translation="MTPTHLQQWIQHPETLNRDTLYELRTLVARYPYFQSLRLLYLKNL
                     YLLHDINFGAELRKAVLYVADRRVLFYFIEGDRYTLKSRKVSSLFSGDLEKEPSVDRTL
                     SLIDAFLATVPEEHSQHTELDYAVDYTAYLMQEEPGVDAEDESEVPKLRGHELIDDFIQ
                     KSESSDASDTRREFLVEKEEETEEEEEPSVSPVTEELDDSCFTETLAKIYIKQHRYDKA
                     LEIIKKLSLNYPKKNAYFADQIRFLEKLIINAKSK"
     CDS             8059..8433
                     /locus_tag="ctg19_62"
                     /transl_table=11
                     /translation="MYLLLVILMLIASVLMCFIVLIQNSKGGGLASGFSSSNQIMGVRK
                     TTDFLEKATWTLAAVMVVFSIVSAYTIPSSTGKGGDVILEQAQQEEKTNPYNMPVGTEA
                     PQSEAPAATTPAEAPAPAAE"
     CDS             8587..9978
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 100.6; E-value: 1.2e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg19_63"
                     /transl_table=11
                     /translation="MTEQLKLKLNDSKATRWGALVIVAFTMMAAYYVNDVVAPLKTMLE
                     TDLAWSSTDFGFFTGGYSFLNVFFLMLIWGGLILDRFGIRFTGKLATILMVGGTALEYY
                     AMTGLAGADATLFGINEIFGYKTGVFVAFAGYSIFGVGAEVAGITVSKIIAKWFKGKEL
                     ATAMGVQVALARIGSQAGYAVAIPLARAFGISTPVLLGLVLLLGGMIAFFIFAVMDKKL
                     DKQMEAAAIAAGTEDEEEKFSFKDVKNILVNPGFWLIALLCVLFYSCVFPFQKFASELM
                     IIKYGINENVAGTFAGLPALGALILTPVFGGFIDKRGKSASIMLLGSAMLICVHFIYAI
                     PDINYWLVAIVLMIILGIAFSLVPSAMWPAVAKIFPVSQLGTAYALIFFIQNIGLWGIP
                     TLIGWVLDAYCISGKKPDGTNMYDYTVPMCIFTGIACLSLIVALLLKKADKKYGYKLEE
                     PNIQK"
     CDS             10001..10351
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_64"
                     /sec_met_domain="PqqD_RRE (E-value: 5.9e-10, bitscore:
                     31.0, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.1e-16, bitscore: 53.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIPEGKVSLLDAVPVRCGHITTEWEGECAVLAYPRFKYEWMRRF
                     LLPKGMSPDIHVRLEEHGTAVWNLIDGHRTVREIISLLARHFGEEENYIPRVTAYVMQL
                     RKDGFIQLTIRN"
     CDS             complement(10359..11417)
                     /locus_tag="ctg19_65"
                     /transl_table=11
                     /translation="MYIMKKNILMLSALFLSITAMAQTDVTTGVMRGKDYGVTYMLPKT
                     EIEIVLQATKHTYTPGEFCRYADRYLRLNNVSAEPEEFWTLDKIETRIAGVPDKDNVYF
                     VKMKDKTVAPLMELTEDGIVRSINIPFSGKPAAKTPEAKATESSIDPRSFLTEEILMSN
                     SSAKMAELVAKEIYSIRESKNALLRGEADNMPKDGAQLKLMLDNLNQQETAMTEMFSGK
                     IKKEPKTFTIRLTPKEMKDEVAFRFSRKLGVVANNDLAGEPYYISVTDLKSPDVSATEE
                     GKKKVDGVAYNLPGKAQVTLMYNNKKLFDDQLPITQFGTVEYLAPVLFNKNSTIKVLFD
                     TATGGLIKVDRE"
     CDS             complement(11479..12585)
                     /locus_tag="ctg19_66"
                     /transl_table=11
                     /translation="MLGLGLTACGSSPKGTNGDQDELAMLIGTYTNGSSKGIYTFRFNQ
                     ETGTAVPLSSAALPNPSYLVPSEDGEFVYAVSEMNDSTAALSSLAFDRETGELRLLNTV
                     PTFGADPCYVATNGREVLTANYSGGTMSVFPLQKDGTLAPADTLFQGSATGPDAIRQAT
                     PHIHCTVFSPDGKYIFATDFSADRILRFVMHPDNPIPHASLEAVGIEADSGPRHLTFSP
                     NGKFAYLITELSGKVIAFSYDDGCLEQIQTITADTVAARGSADIHLSPDGKYLYASNRL
                     KEDGIAIFAVNPENGTLAKVGYQPTGIHPRNFNITPNGKYLLAACRDSNVIQVYKRNEV
                     TGLLEDTHQDIVVDMPVCVQFVSSVNNL"
     CDS             complement(12708..15536)
                     /locus_tag="ctg19_67"
                     /transl_table=11
                     /translation="MKNLIALTLLLGGSTLLCAQKPAKTPATYKPVKSEMYRKGWIDFN
                     KNGVKDVYEDPSAPLEARIENLLQQMTLDEKTCQMVTLYGYKRVLKDDLPTPEWKELLW
                     KDGIGAIDEHLNGFQQWGLPPSDNAYVWPASRHAWALNEVQRFFVEDTRLGIPVDFTNE
                     GIRGVESYRATNFPTQLGLGHTWNRELIRQVGLITGREARMLGYTNVYAPILDVGRDQR
                     WGRYEEVYGESPYLVAELGIEMVRGLQHNHQVAATGKHFAAYSNNKGAREGMARVDPQM
                     SPREVENIHIYPFKRVIREAGMLGVMSSYNDYDGIPVQGSYYWLTTRLRGEMGFRGYVV
                     SDSDAVEYLYTKHGTAKDMKEAVRQSVEAGLNVRCTFRSPDSFVLPLRELVKEGGLSEE
                     VINDRVRDILRVKFLIGLFDAPYQTDLADADREVEKEENEAIALQASRESIVLLKNAGE
                     LLPLDINSTKKIAVCGPNANEEGYALTHYGPLAVEVTTVLEGIQEKTKGKAEVLYTKGC
                     DLVDAHWPESEIIDYPLTDDEQAEIDKAVENARQADVAIVVLGGGQRTCGENKSRTSLD
                     LPGRQLQLLQAIQATGKPVVLILINGRPLSINWADKFVPAILEAWYPGSKGGTALADIL
                     FGDYNPGGKLTVTFPKTVGQIPFNFPCKPSSQIDGGKNPGPTGNMSRINGALYPFGYGL
                     SYTTFEYSDLDITPRIITPNESATVRLKVTNTGKRAGDEVVQLYIRDVLSSITTYEKNL
                     AGFQRIHLEPGEAQELSFTIDRKHLELLDADMKWVVEPGDFVLMAGASSEDIRLNGTLT
                     VEDYQTRAKAIEAQKPAKRVSTSTNPEDAENVLDEKINTAWQGNKGDYITFALKNGAKV
                     DKVAIAFTRDNNLPATFEIQLSGGGGQFLTVYSGTVSEYGKLISYPFKGTTASDLRIVL
                     NDDRVSIAEVKF"
ORIGIN
        1 ttattggttt ggcgctgttt gctttcatcg caggtgacgc gtggaaagtg cttcagccac
       61 accagtcaca agacgtaggt gaagtgaacg gggaatcaat ttccgctcag gattttcaag
      121 cattggtaga agaatataca gaagtcatca agttctccag tggcaacagt gcattgagcg
      181 atgagcagac aaaccaaatc aaagatgaag tatggagaac atacgtcaat aataagctga
      241 ttgaaaagga agcaaagaaa ctcggtctgg ttgtatcgaa ggctgagatt caggctatca
      301 ttaatgccgg tgtgcatccg atgctgcaac agactccgtt ccgtaatcct cagaccggtg
      361 cgtttgataa ggatatgttg aagaagttct tggtggacta ttcaaaaatg aataaggcgc
      421 agatgccttc acaatatgca gaatactatg aatccatgta caagttctgg tctttcctcg
      481 aaaagtctct tatccaggca cgtcttcagg agaagtatca ggctttgatt acaaaatctc
      541 ttttctccaa cccggtagaa gctcaggacg cttttgatgc aagagtagag cagtcagacc
      601 tgctgcttgc tgcagttccc tattcttcta tcgttgactc taccatcgtt atcaaggatt
      661 ctgatttgaa ggctgcatac gacaagaaga aagaacagtt caagcaatat gtggaaactc
      721 gcaatatcaa gttcattgat gtgcaagtta ctgcaagtgc agaagacaga gctgctctcc
      781 agaaggaaat ggaagaatac accgaacaac ttactgccaa tccttctgac tatactacct
      841 tcatccgttc taccggttcc gaagctcctt atacagactt gttctacact actaagtctc
      901 tgcctgctga tgtgacagcc cgtttggatt ctgttgcggt gggtggtgta ttcggacctt
      961 attataacgt atcggacaat actcttaact ctttcaagaa attggctact gctgctatgc
     1021 cggactctat cgagttccgt cagattcagg tagttgccga agatgctgaa aagacgaaga
     1081 ctttagccga cagcatctac aatgctatta agggtggtgc cagctttgct gaaattgcga
     1141 agaagtacgg tcagaccggt gagcctacct ggatttcttc tgctaactac gaaggcgcac
     1201 agattgacgg tgacaacttg aaatacatta ccgctgtcac aactttggga cagaacgaac
     1261 tgaccaatct ggcgttggga caagcaaatg tcattttgca agtaaccaac aagaaggctg
     1321 tcaaggataa atataaggta gccgttatca agcgtccggt agaattcagc aaggaaactt
     1381 acagcaaggc atacaatgag tttagccagt tcatcgctgc aaacaatact ttagagaaaa
     1441 tgattgccaa tgcggaagat gccggttaca agttgctgga tagagccgac ttgtacagct
     1501 ctgaacatgg tatcggtggt atcagaggaa ccaaagatgc tttgaaatgg gcgtttgagg
     1561 caaaagccgg tgaagtttcc ggtttgtacg aatgtggcga gagcgaccgt atgctggtag
     1621 taggtgttgc aagtattgtt cctgaaggtt atcgcccact ggctttggta aaggaccagt
     1681 tgagagctga aattctccgt gacaagaaag cagagaagat tatggctgat atgaaggctg
     1741 ccaatgcaac ttcgttcgag cagtacaaga atatggcaaa tgctgttagt gattctgtaa
     1801 agcacgttac tttctctgct cctgcctata tcccggcatt gcgtagcagc gaacctctgg
     1861 taggcgcata cgcttctatt gccgaagtga acaagctgag tgctcctatc aagggtaacg
     1921 gtggtgtatt cgttctgcaa ccttatgcaa aagagaagct gaacgaaaca ttcaacaagg
     1981 aaactgaaga ggctaacttg gctaacatgc acgcacgcat ggcaagccag ttcatcagtg
     2041 acttgtatct gaaagccaac gtaaaagacc aacgttattt attcttctaa gaatagaaaa
     2101 cccatattga aaagccgttc ggtactcccg ggcggctttt tcattctctg tacatttcat
     2161 tttctatact ctccgttgtc tttgtgcaac tttattccta cctttgcatt cttgaaagag
     2221 ttttgttttt aatgaaaaac gatatgcaga aacgacctct attgggcttg acgctctctg
     2281 aattgcagaa tgtggtgaag aatctgggaa tgcccggttt ctctgccaag cagatagctt
     2341 cctggctgta tgacaagaag gtgacttcta tagacgaaat gagcaatctt tcgttgaagc
     2401 atcgggaatt gctgaaagaa atctatgagg taggtgccga agcgccggta gatgccatgc
     2461 gctctgtaga cggtacggtg aaatacttgt accgggcagg cgaggggcat ttcgtggaag
     2521 ctgtctatat acccgacgaa gacagggcta cgctttgtgt ctcctcgcag gtgggctgta
     2581 agatgaattg caagttctgt atgaccggca aacaaggttt tactgccaat ctgacatcca
     2641 accagattat taatcaaatc aattcgttgc ccgaaaggga caagcttacc aatgtggtaa
     2701 tgatgggcat gggtgaacca cttgataatc tggacgaggt attgaaagcg ctggaaataa
     2761 tgaccgcctc ttatgggtat gcgtggagtc ccaagcgtgt tacactttct tctgtgggat
     2821 tgaagaaggg cttgcagcgt tttattgagg aatcggactg ccatctggct atcagccttc
     2881 attcgccgat acctttgcaa cgccgcgaac tgatgccggc agagaaggcg ttctccatca
     2941 cggagattgt ggaattgtta agaaactatg attttagcaa acagcgcaga ctatcttttg
     3001 aatatattgt tttcaaagga gtgaatgact cgttaccgta tgcaaaggaa cttctgaagc
     3061 tgctacgcgg gctggactgc cggattaacc tgattcgttt tcatgccata cctggagtga
     3121 atcttgaagg ggctgatatg gaaaccatga ctgcgttccg tgattatctg acttcgcacg
     3181 gtctgtttac cactatacgg tcatcgcgtg gagaggatat atttgccgct tgtggcatgt
     3241 tgtccactgc caagcaggag gagaataaag aagaattaat ataaattatt aacttaggta
     3301 gggaggatat tacgcattct tcgtagcttt gtgaaaaact aaaatgatag agatatgaga
     3361 aagcacttgt tttatttaag tatggttctc gtactgacac ttttttccgc ttgcggtggt
     3421 ggtaaaaagg gtgtgtttac tccgacctcc agtggtcgtg cgtatgaagt tctggtagtg
     3481 gtggagcccg gcttgtggga acgtcctgcc ggtagggcgc ttttcgatgt gcttgattct
     3541 gatgttccgg ggcttcccca gtcagaacgt tcattccgaa tcatgtatac tgccccttcc
     3601 aattatgatg ccactttaaa actgattcgt aatatcatta ttgtcgatgt gaacaaggac
     3661 ctctataccc agcctaaatt caagtatgca aggaatgtat atgctgctcc tcagtctatt
     3721 ctcactattc aggcaccgga cgaggcttcg ttcgagaaat ttgtggagga gaataggcag
     3781 gtaatcatcg atttctttac ccatgcggaa atgaatcgtc agatttcagt attgaaggac
     3841 aagcatagcg actatatagc aacgaaggtg aaaagccagt tcgattgcga tgtatgggtg
     3901 ccgggcgaac tgacatctac caaggagggt gagaacttct tctgggcagg tacgaatgca
     3961 gctaccggcg accagaactt tgtaatctac tcttatcctt atacggataa ggatacgttt
     4021 actaaagaat attttgttca taaacgcgat tccgtgatga aggttaatat ccctggtgcc
     4081 cgtgaaggca tgtatatgtc gatggattct ctgatgaccg atgtacgccc catcagtgtg
     4141 cagggagact atgcactgga ggcccgcggc ttgtggcgca taaagggtga cttcatgggc
     4201 ggtccgttcg tatcgcatgt acgtttggac aaggccaatc agcgtattat cgtatctgaa
     4261 atatttattt attcacctga taaaatgaaa cgtaatctgg tacgtcagat ggaggcttcg
     4321 ctctatacct tgaaactgcc cggcagcaag caggaaggtg cggaaattcc ggtaggcgta
     4381 acctcaaaag atactactaa taataagtaa taaaaatgga agacaacaaa ataagagtcg
     4441 gcattacaca aggcgacatt aatggtgtag ggtatgaagt gattttaaag acgtttgcag
     4501 acccggtgat gctggaattg tgcacgccga ttatctacgg ttcgcctaaa gtggcagctt
     4561 atcatcgtaa atcattggac ttgcctacca acttcagtat cgtcaactcc gcctccgaag
     4621 cggttcccaa tcgcttgagt gtagtgaact gtacggatga tgaagtaaag gttgagttct
     4681 ctaaacctga cgttgaagct ggtaaagctg cacttggtgc actggaaaaa gccattgagg
     4741 aatataagga gggaatgata gacgtgattg tcacagctcc catcaacaag cataccatcc
     4801 agtcggagga gtttgccttc cccggacata cggagtatat agagcaaaaa ttgggagatg
     4861 gcgagaaggc ccttatgatt ctgatgaaag atgacttccg ggtagcattg gtgaccggac
     4921 atattcccgt taaagagata gccggaagca tcaccaaaga actgatacaa gaaaaactga
     4981 agatattcaa ccgctccttg aagcaggatt ttgctatcag cgcaccgcgt attgcagtgc
     5041 tttcgctgaa tccgcatgca ggagacggcg gattgctggg aactgaagag caggagatta
     5101 tcattccggc catcaacgaa atggctgcta agggtatgct ttgctatggt ccttatccgg
     5161 cagacgggtt tatgggctca gataacttta cccattttga tggtatcctg gccatgtatc
     5221 acgaccaggg gctggcaccg ttcaaggcat tggctatgga cgagggcgtg aactatactg
     5281 ccggcttgcc ggtgatacgc acttcgcctg ctcatggcac ggcctacgat attgccggga
     5341 aaggaatcgc ctctgaagat tcattccggc aggctatcta tgtggcaata gatgtgttcc
     5401 gtaaccgcca gcgtgagaaa gaggcacatg caaatccgct gcgcaagcaa tattacgaga
     5461 aacgtgacga tagcgacaaa ctgaaactcg atagtgtaga agaagatttg tagaatgaca
     5521 aaagcggaaa tacaacaagt aaaattacgt ttcggcatta tcggcaacaa tgaagcgctg
     5581 atgcgtgcca ttgatatcgc tatccaggta gcgcccaccg acttgtctgt actgattacc
     5641 ggagagagtg gtgtgggaaa ggagagcttt ccgcagataa tacaccagta cagccggcgc
     5701 aagcatggac agtacattgc cgtgaactgt ggagccattc ccgaagggac gattgactcg
     5761 gaactgttcg gtcatgagaa gggcgcattt accggggcta tcggcgaacg gaaggggtat
     5821 ttcggtgagg ccaacggcgg aacaatcttc cttgatgaag tcggcgaatt gcctttgcct
     5881 acccaggcac gcttgttgcg tgtgctcgag agcggtgaat tcatcaaagt aggttcttct
     5941 aaggtggaaa agaccgatgt gcgtattgtt gccgctacca atgtaaactt gacacaagcc
     6001 attgctgacg gacgttttcg tgaagacttg tattaccgtt tgaacacagt tcctattcag
     6061 gtccctccat tgcgcgaacg cggtgaagac gtggtgctgc tgttccgaaa gtttgcttcg
     6121 gactttgcag aaaagtaccg tatgcctgcc attcagctga cggaagacgg caagcaagtg
     6181 ttgctgggct actcatggcc gggtaatgtg cgccagttga agaatatcac cgagcagata
     6241 tccatcattg agaccaatcg tgaaatcaat gcatccatac tgaagggcta tctgcctgag
     6301 cagaacaata tgcagcgcct gcctgccttg tttggagtga aggaggacaa gagctttggg
     6361 agtgaacggg aaattctcta ccaggttctg tttgatatgc gccaggatgt aacggacttg
     6421 aaaaagttgg tgcatgagat tatggctgaa aggggaacgg tagccaatcc ggcggttgcc
     6481 acatcggcct actatacgcc ggctactccg gcggtggtac ctccggtaac atccagtgtt
     6541 cccaccatta tacatccttc ggtaaagccg gttactccgg tggacgatga tttccaggat
     6601 acggaagaat atgtggagga gtcactctcc ctggatgaag tggagaaaga aatgatacgt
     6661 aaggcgcttg aaaaacatca cggcaagcgt aagagtgcgg ctcaggattt gaatatctct
     6721 gagcgtacgt tatacagaaa gataaaagaa tatggattgg attaaaaaag cggcatttgc
     6781 ttccttgttg gtaagcttgt tatttctggt gaattcatgt agtatgaagt tgggacttgc
     6841 tccgataagc tctatcgact atacaaaggt aaaaacgatt tccattgccg atttccagaa
     6901 ccgggcagag tatgtatatg caccgctggc aacagaattt aaccagaaaa tgaaggatat
     6961 gttcattcag cagactcgcc tgcaactggt gaattccgga ggagacctgg aaatagacgg
     7021 agaaataacc ggctacaatc aatataatga atcggtggat gccagcggct actcttcgaa
     7081 ggtgaaggtg acgctgactg tcaacgtgcg ctacaccaat aacacgaacc atgaggagga
     7141 ctttgaacag cagttctcgg ctttccagac ctatgattcc tcaaaattgc tgaccgaagt
     7201 gcaggaccag ctgataacct tgatggtgaa agacattgcc gaacagattt tcaatgcaac
     7261 tgtagctaac tggtaaactc atgacgccta cccatttgca acaatggatt cagcatcccg
     7321 agacgctgaa tagggatact ttgtacgagc ttcgcacatt ggtggcacgc tatccttatt
     7381 tccagtcgct ccgtttgctc tatctgaaaa acctctatct actgcacgac atcaactttg
     7441 gcgcggagtt gcgcaaggct gtgttgtatg tggcagaccg tcgtgtgctg ttttacttta
     7501 tagagggtga ccgctatact ttgaaatccc ggaaggtctc gtcgctgttt tccggcgatt
     7561 tggagaaaga gccgagtgtg gaccgtaccc tttccttgat tgacgcattt ctggctactg
     7621 ttcccgaaga gcattcacag catacggagc tggattatgc ggtggattat acggcctatt
     7681 taatgcagga agaacccggt gtggatgcag aagatgagtc ggaagtgcct aaactgcgtg
     7741 ggcatgaatt gatagatgac tttatccaaa agagtgagtc ttcggatgcc tcggatacga
     7801 gaagggagtt tcttgtagag aaggaggaag agactgaaga agaggaagaa ccctcagtat
     7861 cgccggtaac ggaagagttg gacgatagct gttttacgga aactttagcc aaaatctata
     7921 taaaacagca ccgatatgac aaggcgcttg aaattattaa aaaattaagt ttgaattatc
     7981 caaaaaaaaa tgcttacttt gcagaccaaa tcagattttt ggagaaattg attattaacg
     8041 ctaaatcaaa ataacaaaat gtatttatta ttagttatct taatgctgat tgcatctgtg
     8101 ctgatgtgct tcattgtatt gattcaaaat tctaaaggag gtggtctggc atcaggcttt
     8161 tcatcatcca accaaattat gggtgtgcgc aagactacgg actttttgga aaaagcaacc
     8221 tggactctgg cagctgtcat ggtagtcttc agtattgttt ctgcttacac tattccttct
     8281 tccacaggca agggcggtga tgtgattctg gaacaggcgc aacaagaaga aaaaactaat
     8341 ccttataaca tgcccgtagg tacagaagct ccgcaatcgg aggcccctgc agctacaact
     8401 ccggctgaag ctcctgctcc tgcagcagaa taagataagg atattgcgga tgactcccgc
     8461 ttggaaaaat aagagaaagg ttgatactga aaaggtgtca gccttttttc gttttgatga
     8521 agtatttatt tacctttgtc agcaatttat gcaatctgat taataaattg aaatccaaat
     8581 agtacaatga cagaacaact caaacttaaa ttgaatgatt ccaaggctac ccgttggggg
     8641 gcattggtga ttgttgcctt cacgatgatg gcagcttatt atgtaaacga cgtggtagca
     8701 ccgttgaaga caatgttgga aacggacttg gcttggtcga gtaccgattt cggattcttt
     8761 accggtggtt atagttttct gaatgttttt ttcctgatgt tgatttgggg aggattaatc
     8821 ctcgaccgct ttggtatccg tttcaccgga aagctggcaa ctatcctgat ggtaggtggt
     8881 acagcacttg aatactatgc aatgacggga cttgccggtg ccgacgcgac tttattcgga
     8941 atcaatgaaa tatttggcta taaaacgggt gtgtttgttg cttttgccgg ttattccatt
     9001 tttggagtag gagcggaggt cgccggtatt acagtttcca aaatcatagc caagtggttt
     9061 aaggggaaag agcttgccac ggctatgggg gtacaagttg ctttagcacg tatcggttcg
     9121 caagccggtt atgccgtagc cattcctttg gcccgtgctt tcggtatttc cacaccggtg
     9181 ttgttgggtt tggttctgtt gttgggcggt atgattgctt tcttcatttt tgcagtgatg
     9241 gacaagaagc tggacaaaca gatggaagct gctgccattg ctgccggtac ggaagatgag
     9301 gaagagaagt tctcttttaa ggatgtgaag aatattctgg tcaatcccgg tttctggctg
     9361 atagcattgc tgtgtgtatt gttctactct tgtgtattcc cattccagaa gtttgcttcc
     9421 gagttgatga ttatcaaata cggtatcaat gagaatgtgg ccggtacatt tgccggactt
     9481 ccggcattgg gagcgctgat tctgactccg gtctttggtg gtttcattga caagcggggc
     9541 aagtccgcat ctatcatgct gctgggctcg gccatgctga tatgtgtgca tttcatttat
     9601 gctattcccg atataaacta ttggctggta gctattgtgc tgatgataat tttgggtatc
     9661 gctttctcgc tggtaccttc tgccatgtgg ccggctgtgg ccaagatatt cccggtaagc
     9721 cagttgggta cggcatacgc attgattttc tttatccaga atatcggtct ttggggtatt
     9781 cctacattga tagggtgggt gcttgatgcc tattgtatat ccggcaagaa accagatgga
     9841 acgaatatgt atgactatac ggtgcctatg tgcattttta ccggtattgc ctgcttgtcc
     9901 cttatagtgg ctctactgct gaagaaggca gacaagaagt atggttataa gctggaagag
     9961 cctaatattc agaaataata ggaaaagcgg ataccgtatg atggaaatac ccgaaggaaa
    10021 agtaagtctg ttggacgctg ttccggtccg ctgtggacat ataacaaccg aatgggaagg
    10081 tgagtgcgcc gtactcgcct acccacggtt taaatacgaa tggatgcgtc gttttttatt
    10141 gccgaagggg atgtctcctg acatccatgt gaggctggaa gaacacggta cagctgtctg
    10201 gaatctgata gatggacatc gtaccgtgcg cgaaatcatc tctctacttg ccaggcactt
    10261 tggggaggaa gagaattata ttccccgggt caccgcctac gtaatgcagt tgcgtaagga
    10321 tggatttatc cagttgacaa tccggaatta gaattccttt attccctatc cacttttatc
    10381 aatcctcccg ttgccgtatc aaacagcact ttgatggtag aattcttgtt gaacagtacc
    10441 ggtgcgaggt attctacggt gccgaattgg gtaatgggaa gttggtcgtc aaacaatttc
    10501 ttattgttat acatcaatgt cacttgtgcc ttgcccggaa ggttataggc tacaccgtcc
    10561 actttctttt tgccttcctc ggtggcagat acatcgggac ttttgaggtc ggtgacgctg
    10621 atataatacg gttcaccggc aaggtcatta ttggccacca ctcccagctt tcgggaaaaa
    10681 cggaaagcca cctcatcttt catctcttta ggcgtcagcc ggatggtgaa tgtcttgggt
    10741 tctttcttta ttttgcccga gaacatttcc gtcatagccg tttcctgctg gttcagattg
    10801 tcaagcatca gcttgagttg ggcgccgtcc ttgggcatat tgtctgcttc gccgcgcagg
    10861 agggcattct tgctttcgcg gatgctgtat atttccttag ccaccagctc ggccatcttg
    10921 gcactggagt tggacatcag tatttcttcc gtcagaaaac tgcgtgggtc aatgctgctt
    10981 tcggtggctt tggcttcggg cgtcttggca gcaggcttac cgctgaacgg aatgttgatg
    11041 gagcggacaa ttccgtcttc ggtaagctcc ataaggggtg ctacggtctt gtctttcatc
    11101 ttcacgaaat agacgttgtc cttatccggt acaccggcta tgcgggtttc tatcttatcc
    11161 agtgtccaga actcctcggg ttcggcagac acgttgttga gacgcagata gcggtcggca
    11221 tatctgcaaa attctccggg agtgtaggta tgcttggtgg cttgcaatac gatttctatt
    11281 tctgttttgg gtaacatata agtcactccg tagtctttgc cacgcatcac accggtggtt
    11341 acgtctgttt gcgccatggc agtgatagac aagaacagag ctgagagcat caatatattc
    11401 ttcttcataa tgtacattcg tttagactga tttagctaag ggacaaagtt aatgaagtta
    11461 tctttgctaa atattgcttt ataaattatt aacagagctg acgaactgta cgcaaaccgg
    11521 catgtcgact acaatgtcct gatgagtatc ttccaagagt ccggtaactt cgtttcgttt
    11581 gtatacctga atgacattgc tgtcgcggca ggcggcaagc aagtatttac cgttgggcgt
    11641 gatgttgaag ttgcggggat ggatgccggt gggctgataa cctacctttg ccaaggtccc
    11701 attttcggga ttcacggcaa agatggcgat gccgtcttct ttcagacggt tgctggcgta
    11761 gaggtatttc ccatccggac tgaggtggat gtctgcactt ccacgggcgg ctacggtgtc
    11821 ggctgtgata gtctgtatct gttccaggca gccgtcgtcg taactgaagg caatgacctt
    11881 accggacagt tcggtgatga gataggcaaa cttcccgtta gggctgaatg tcagatggcg
    11941 cgggccggaa tctgcctcaa tgccaacggc ttccagagaa gcatgaggaa tagggttgtc
    12001 ggggtgcatc acaaagcgca ggatgcggtc ggcactgaag tcggtggcga agatatactt
    12061 tccgtccggt gaaaagaccg tgcaatggat gtggggagtg gcttgccgta tggcgtcggg
    12121 accggtggca gagccttgaa agagcgtgtc tgcaggagcc aaagtgccgt ctttctgtaa
    12181 aggaaagacg gacatggttc caccgctgta gttggcagtc aacacttccc ggccattggt
    12241 ggccacgtag caggggtcgg cgccgaaggt gggaacggtg ttcagcaggc gcagttctcc
    12301 cgtttcccgg tcgaaggcaa gggagctgag ggctgctgtg ctgtcgttca tttcactgac
    12361 ggcatagaca aattcgccat cttccgaggg gacgaggtag gagggattgg gcaatgccgc
    12421 tgaactgagc ggaacggctg ttcccgtctc ctgattaaag cggaaggtat agataccctt
    12481 gcttgagcca ttcgtgtaag tacctattag catggcgagt tcgtcctggt caccgttagt
    12541 gccctttgga gaagagccac atgctgtcaa acctaatccg agcatacaga aaagaagtgt
    12601 tttcattaat ttaatgtgtt aatgtgccaa tatgctaatg tgctaattgg ctgcgctgta
    12661 tatgctgcat ggtcattggt acattagcat attggcacat tagcacatta aaatttaact
    12721 tcggcaatac tgacgcggtc atcgttcagc acgatgcgga ggtcgctggc ggtagtgcct
    12781 ttgaacggat aggaaatcag tttgccgtat tcgctgacgg tgcccgaata tacggtgagg
    12841 aactgtccgc caccgcccga gagctggatt tcgaaggttg ccggcaggtt gttgtcacgt
    12901 gtaaaggcaa tggcaacttt atctaccttg gctccgttct ttaaggcaaa ggtaatataa
    12961 tctcccttat ttccttgcca tgcggtattg attttttcgt cgagcacgtt ttcggcatcc
    13021 tctgggttgg tgctggtact cacacgcttt gctggttttt gggcttcaat ggctttggca
    13081 cgggtctggt agtcttctac ggtcagcgtt ccgttcaggc ggatgtcttc ggaagaggcg
    13141 ccggccatga gcacgaagtc gccgggttcc accacccatt tcatgtcagc gtccagaagc
    13201 tccaggtgct tgcggtcgat ggtgaaggac agctcctggg cttcgcccgg ttcgaggtgg
    13261 atgcgctgga agcctgcaag attcttttcg taggtggtga tgctgctcag tacgtcgcgg
    13321 atatagagct gcactacttc atctccggca cgtttgccgg tgttggtcac cttcaggcgg
    13381 acggtggcag actcgttcgg ggtgatgatt cggggggtga tgtcgaggtc ggagtactcg
    13441 aaggtggtgt agctcaagcc gtaaccgaag gggtagagtg ctccgttgat gcgtgacatg
    13501 ttgcccgtag gtcccggatt cttaccgccg tctatctgtg aagaaggttt gcaggggaag
    13561 ttgaagggga tttgccctac ggtcttgggg aaggtcaccg tcagctttcc accggggttg
    13621 tagtcgccga agaggatgtc ggccagggct gttccgcctt tggagccggg ataccaggct
    13681 tcgaggatag cggggacgaa cttgtctgcc cagttgatgg agagcgggcg tccgttgatg
    13741 agtatcagta cgacgggctt gcccgtggct tgtatggctt gaagcagttg caactgccga
    13801 ccgggcaggt cgaggctggt gcgcgatttg ttttcgccgc aggtgcgttg tccgccgccc
    13861 aatactacga tggcaacatc agcttgacgg gcattttcta cggctttgtc tatctcggct
    13921 tgttcgtcgt cggtcagcgg atagtctatg atttcacttt cgggccagtg ggcgtccacc
    13981 aggtcgcagc ctttggtgta gagcacctct gccttgcctt ttgtcttttc ttgaatgcct
    14041 tccagcacag tggtcacttc tacggcaagt gggccgtaat gggtcagcgc gtagccttct
    14101 tcattggcat tgggaccaca gacggcaatc ttcttggtgg agttgatgtc taagggcaat
    14161 agttcaccgg cattcttcag cagaacgatg gactcgcggg atgcctgcaa ggcaatggct
    14221 tcgttctctt ctttttccac ttcacggtcg gcatcggcaa ggtctgtctg atagggggca
    14281 tcgaacagac cgatgaggaa ctttacccga aggatgtcgc gcacgcggtc gttgatgact
    14341 tcttcgctca gtccgccttc cttcaccagt tcgcggaggg gaaggacgaa ggagtcgggc
    14401 gagcggaagg tgcagcgtac gttcagtccg gcttccacgc tttggcggac ggcttctttc
    14461 atgtctttgg cggtgccgtg cttggtgtag aggtattcta cggcgtcact gtcggatacg
    14521 acgtagccac ggaatcccat ttcgccacgc aggcgggtgg tgagccagta gtagctgccc
    14581 tgcacgggga tgccgtcgta atcgttgtac gaactcatta cgcccagcat gccagcttcc
    14641 cggatgacgc gtttgaaggg gtagatgtgt atgttttcca cttcgcgcgg cgacatttgc
    14701 gggtccacgc gtgccatgcc ttcgcgggcg cctttgttgt tactgtaagc ggcaaagtgc
    14761 ttgccggtgg cggccacttg gtggttgtgc tgcaagccgc gcaccatttc gatgcccagt
    14821 tcggctacga ggtagggaga ttcgccgtaa acttcttcgt agcgtcccca gcgctggtcg
    14881 cgtcctacgt cgaggatggg ggcgtagacg ttggtgtagc ccagcatgcg ggcttcgcgt
    14941 ccggtgatga gtcctacttg gcgaatcagt tcacggttcc aggtatgtcc cagtcccagt
    15001 tgggtgggga agttggtggc gcggtagctt tccacgccgc gtatgccttc gttggtaaag
    15061 tctacgggga tgccgagacg ggtatcttcc acaaagaacc gttgcacctc gtttagtgcc
    15121 caggcgtggc gcgaggcggg ccagacgtag gcattgtccg agggaggcag cccccattgc
    15181 tggaagccgt tcaggtgttc gtcgatggcg ccgatgccgt ctttccagag cagctctttc
    15241 cattcggggg tggggaggtc gtctttcagt acgcgtttgt agccgtagag ggtgaccatt
    15301 tggcaggtct tttcgtccag cgtcatctgt tgcagcaggt tttcgatgcg tgcttcgagc
    15361 ggggcggagg ggtcttcgta cacgtctttc actccgtttt tgttgaagtc tatccaacct
    15421 ttgcggtaca tttcactttt caccggcttg taggttgccg gtgttttggc aggcttttgt
    15481 gcgcagagca gtgtgcttcc tccaagcagc agggttaggg caataaggtt cttcatgata
    15541 tgttctaaaa atctcttggt tattattgtt tcttttgttg acaaaaatac ggctaatgtg
    15601 tgaaataaag ggataaaata gtccgaagta tcggctttta ttgtccgaag ggtcttcctc
    15661 ttactaaaaa tatactccaa gacgctaccg gggaattcaa atcattatta gacgaaacat
    15721 atcattcact tttaaaaaga aagaacacta taataacctg aaaagtagat gcaatcgcgg
    15781 tgtatacaag tattacggct acatctgtta aacgagggtg tatttatata ataggaatct
    15841 gttggcggaa ttgttgcttg tacggaagaa ctttcttttc aaccttggga tgtctaaacc
    15901 aaaccttggt ttagacatcc caaggttggg tatggaaaaa ccaaagtttg ggatagattg
    15961 cttccttaat tctttccggt ttttcagtta acttcagaga ctttttccgt taacttccca
    16021 tctcttttgt acaaatatcc attacagaag atagatattc cctcttgcag ggggtaattc
    16081 tgtcaacgga tactggcttt ggtagctgtt tgaacattga tgacaatggg gtgcacatat
    16141 tctatgtatg gaagattatt gtttttatca cgaaaagtca gtattagcta atatttgtaa
    16201 atatatggtg attgctaata aaagaatatg tatctttggg ccaaagaaag cggtagagga
    16261 tgaaaaataa agtagcattt atcccttttt caccctccct acttagcaat gagttacgca
    16321 atcttttaaa tttcagaccg ttacaaagtc atggggttga ctggatttga cagcgggcag
    16381 aaatg
//
