LOCUS       c00012_gnlPro..        15823 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JGGBPCPD_12.
ACCESSION   c00012_gnlPro..
VERSION     c00012_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 18:07:35
            Original ID  :: gnl|Prokka|JGGBPCPD_12
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15823
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15823
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:5823]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..5823
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15823
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15823
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(3..782)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_1"
                     /sec_met_domain="IlvN (E-value: 7.2e-49, bitscore: 155.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 9.9e-21, bitscore: 64.4,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVMNFGGVDENVVTREEFPLEKAREVLKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRKGGKTWEKAVADGWVPGETLFDIEEACEKATIIQYLLSDAAQI
                     EVWPRIKKYLTPGKALYFSHGFGITYKERTNIIPPADVDVILVAPKGSGTSLRRMFLQG
                     RGLNSSYAIFQDATGKAWDRVIALGIGVGSGYLFETTFKKEVYSDLTGERGTLMGAIQG
                     LLLAQYETLRENGHEPSEAFNETVEELTQSLMPLFAEN"
     CDS             complement(824..1555)
                     /locus_tag="ctg12_2"
                     /transl_table=11
                     /translation="MEKNKVGEFHFVTESYLMDFRGRITIPMIGTYLLHAASCHAADRG
                     FGYNDMTERHTAWVLSRLAIEMTSYPAMSESVTLYTWVDEVGKLFTSRCFELVNGEGKT
                     FGFARSIWAAIDMETRRPTLLDVEGLSAYITDRPCPIEKPGKIAPVENNTSGEPYRVKY
                     SDLDVNGHLNSIKYMEHLLDLFDISLFREKEISRFEIAYQSEGKYGMELTLHNQEVSPG
                     KYNMAICNDGKAISRAAVTWI"
     CDS             complement(1592..2146)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_3"
                     /sec_met_domain="ALS_ss_C (E-value: 1.5e-18, bitscore:
                     56.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKQLYTVIIFSENTVGLLNQITVIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDTIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEDLIRKYNARILEMNEDCVVLEKSGHYDETQALFKELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLSAMEKKLQEKHV"
     CDS             complement(2159..3856)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.4e-51, bitscore:
                     162.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQL
                     KHILVRHEQGATHAAQGYARVSGKVGVTVVTSGPGATNTITGIADALMDSTPMVVIAGQ
                     VPSPLLGTDAFQEVDVIGITQPITKWAYQIRRPEEIAWAVSRAFYIASTGRPGPVVLDL
                     AKDAQVGLVDYEYQKVDYVRSYQPEPDIREERIEAAASLINNAKKPFCLVGQGVILGGA
                     EEELKEFLLKNDIPAGSTVLGLSALPSDFPLNKGMLGMHGNVGPNRKTNECDVLIAIGM
                     RFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERKR
                     PEWNAEFEPDEKEEYNKVIEKELYPTEGQLKMGEVVRKVSEATDNDAILVTDVGQNQMM
                     GVRYFKYKQTRSVVTSGGLGTMGFGLPAAIGAKLGAPDRTVCFFTGDGGIQMTIQELGT
                     IMQENLNVKIIVLNNNFLGMVRQWQELFFNERYSNTIMKNPDFVAIAKAFGIASRAVDK
                     REDLDEAIAEMLNHDGAYMLVANVETCGMVYPMVPAGGSVTNMILGDK"
     CDS             complement(3988..5823)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_5"
                     /sec_met_domain="ILVD_EDD (E-value: 3.3e-218, bitscore:
                     715.1, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMKNPLRSSYSTEGRRMAGARALWRANGMKEEQFGKPIIAIVNSF
                     TQFVPGHVHLHEIGQQVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIAD
                     SVEYMVNAHKADAMVCISNCDKITPGMLMASMRLNIPTIFVSGGPMEAGNLDGRALDLI
                     DAMIEAADDSISDEQVEKVERSACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTVVAT
                     HANRTRLFKKAAKMIVDNAFKYYRDGDDSVLPRSIATRQAFLNAMSLDIAMGGSTNTVL
                     HLLAVAHEAEVDFTMKDIDMLSRKTPVICKVAPSCSYHVEDVNRAGGIIGIMNELVKAG
                     LVDGSVKRADGLTLNEAIDQYCITSVNVTEEAINIYKSAPAHRFNLVLGSQESYYKELD
                     TDRATGCIRDVEHAYVKDGGLAVLYGNIAQDGCVVKTAGVDESIFRFAGPAKVFDSQDA
                     ACEGILKDQVVSGDVVVITYEGPKGGPGMQEMLYPTSYIKSKHLGKECALITDGRFSGG
                     TSGLSIGHISPEAAAGGAIGLVKDGDIIEINIPERTIHVKVTDEELAKRREAEEARGTK
                     AFTPPFRQRTVSKALKAYAKMVASADKGGVRIVED"
     CDS             complement(6194..7657)
                     /locus_tag="ctg12_6"
                     /transl_table=11
                     /translation="MKKQFIYFLSLFVMCLAACSNPVDLTALNLDSANINRLIPFRGEL
                     NNGVKQLYPEEPYKAFWAENWKTPEQSISWKVNTDGEDYMAEMIVSVNRMGDGEETELV
                     LSNGTDSVICRINTTGWQRCRFPRPLHFNKGTSILSLKIGKPGKQDDFNVYLYSLEVTR
                     PETYERLRAEATSLRSNTSWMADLPYGFFFHWNSKSMPQSGEPLAYEDAVNNFDVDRFA
                     RTVYECGGKLIFFTTSWAEYYFPAPIQAIDSILPGRTTKRDLVADLSDALGKYGIRLIL
                     YYHVGHGDKEWWDKQHYTRDNAGDLFTNVEKIVGEISQRYGNRLAGLWMDDGIGYYPNG
                     ASFEKIAKAAKSGNKELAICFNSWILPKLTDFQDYYAGELGLSLASAGVNDPSLPLDGN
                     GLFHGGPQDGLQATFSGTLEPGDWTHIYKDSIIGDPVLSIDELTQVVKESNKRKNLPMI
                     NVRIYQDGTISPKSYALLKELNNRISKGE"
     CDS             complement(7730..9172)
                     /locus_tag="ctg12_7"
                     /transl_table=11
                     /translation="MKRMKTLIKNILLAVPVILSASCSDWLEEDPKTFISPSSFYQTVE
                     DFDGALKGLYPQGQNLNLTEVFADYNDKPESAEQVGDIWANNPGYGFYAFRNAWSGPYS
                     TIKNANMILESIEDKDFTAETKNRIIGEAKCLRAWSYFTLVQFFGDVPLRDKVVTSDAD
                     VAIDRMPQADIYQFIFDDILDAEQKLPEEAQDMGRVNKWVVKAIMARIYLTSAGFPMNQ
                     KENYAKAKEKALEVINSGQYSLMPTFDKVFKTERYTAETIWAQLFSAPDSYSGMHNESS
                     PIGSQTALYLPTDAFIASFDKGDMRKEWGIKPEYVNAKGNKVIARTYYNKYINEEYLEQ
                     ELPASNTNILTWQTQLIRLAEMYLIAAEAENEINGPAGAYQYINAIRKRARVDQNDPTN
                     VPDLSGLSQDQFREAVLLERQHELYEEGFAWYDLKRTQTFDKVQKARGSRLNVPIGAYN
                     NTWLIPDTEILNNNIPQNPDYR"
     CDS             complement(9178..12492)
                     /locus_tag="ctg12_8"
                     /transl_table=11
                     /translation="MYKYMKLTNLIRINNGKSVSRLLFITALSSISLFSYAQHQQVRLT
                     GSNVTLKTAFKQIEQQTKLFVDYNTQEVNDSRVLTKLPKNSNVKEVMEQLLEGSGCSIT
                     FSNGHIIINKQARTVSSTKNISGVVKDETGEPVIGANVVVKGTTNGTVTDMNGRYSLEV
                     PEGGVLQISYIGYNTQEVKVGSGDVVNVSLREDSEALDEVVVIGYGTVKKSDLTGAVGS
                     VQMKDVSQVGITSADRALQGQIAGVQVNARTGQPGESMMIRVRGSNSLAGGNEPLYVID
                     GMPVEKMNSDINPEDILSMEVLKDASSTAIYGSRGANGVVMITTKRGRTGDTVLEYNGY
                     VGVSSLRKKLDLLGKDDYIAMVNEVSQNDGNGIAITSEQAALLPNNDWQDLAYQTALTH
                     SHQVSVSGGTDKTKLYSSLNYMNQEGIIKGSDYNRFALRINGDQKLARNLSLNASIAYS
                     YGTQNTANSNADGWGAIAYTAMVMAPIQEIRDADGKYTNFSGTPWGGTNPVGMAELYKN
                     KTVNSRLLANMSLIYEIIDGLTFRVNAGAEVNAGSSDRYIPIGLSAGGKLDGDASKSKS
                     NYYTIINENILTYDKRFNKNHALNLMGGVTFQTYQYNDLGGSGTGFLRDVYETNNLGVA
                     STPGTPSSGYSDYRMASFLGRANYNLMERYLLTVTARYDGSSKFSKNHKFAFFPSAALA
                     WRLSEENFMQDIDWLSNLKLRASIGQTGNQSISPYQTFARLGTSGPIFGDGKDIGFGLS
                     SMANDDLKWETTTQTDIGVDFGFFSNRLNIGFDYYWKQTRDLLYNATLPPSSGYSSMLR
                     NLGRIDNKGFEISINTINMKGKVNWTTNLNITSNRSIVKDLGSDVYGNKIQRIDAPIGG
                     GNWFPLFVGKAPFQLYGYEIEGIYQTDEEARLNGEATKKAGDYRYKDTDGKAGITTGDK
                     TIIANTQPKFTFGLTNIINWNNFELSFLLIGSVGGDIVNEFNKSITNIGGTWNIRKDVW
                     ENHWTPENPNAKYARASVATKDYLAFGDPSSVWVENGSYLRFKDIKLAYTLPSQWFAGS
                     RKPNISVYLSGQNLITITSYSHYDPEASWTSSAVNGWDRGVYPSAKSFTLGLQVKF"
     CDS             complement(12639..13634)
                     /locus_tag="ctg12_9"
                     /transl_table=11
                     /translation="MEENNKIKQLMQLYFGKHFSRYGRILFGRWLKADDAKTEKEEMLQ
                     DLWKKSQPEVTDSTHSDWKALQRHLSVLPVRERSVPFYRQWLKYAAVIVLMMMTAGTTY
                     WATDRFKPVRHVEMAQVFVPYGESEQVVLPDGSKVWVDAGTLLVYPKDFTDTDTRTVYL
                     TGQASFSVRKNPEQPFVVKTTYLDVQALGTVFTVEAYPGDSCSMATLEEGSVLVSVRNE
                     DIQPTVLKPDQQLVYSHSEHTVMVHSIDASLYNMERNGYLIFENTSFSRLMASLERKFN
                     VTIHYNSQKFAGEYYNVKFSPDEKLEDVLNILQQLIGIHYKIKGKVVFIN"
     CDS             complement(13832..14389)
                     /locus_tag="ctg12_10"
                     /transl_table=11
                     /translation="MELPEEQHILREIARGNIKAFEQLFFDYQPRLVYFLVGLTHDKEI
                     SRDISQDLFLSIWKDREKLRDVRSFSSYLFQMARFTVYDYFDRLAVSEKYTNEFLLEAS
                     ISQSEEEAMFARELQNLINRTVEQMSPQRKLIYKMSREQGLSNDEIATRLGISKRTVEN
                     HLTAALSILRKVLYLFLFTCLG"
ORIGIN
        1 ccgttttcag cgaacagcgg catcaacgac tgtgtcagtt cttctactgt ttcgttgaat
       61 gcttctgaag gttcgtgacc gttttcacgc agtgtttcgt actgagccag cagcaatccc
      121 tggatagctc ccatcaaagt accacgttcg ccggtcaggt cagaataaac ttctttcttg
      181 aatgttgttt caaacaagta accagaacca acaccgatac ccagtgcaat cacgcgatcc
      241 catgctttgc ctgttgcatc ctggaagatt gcgtagcttg agttcagacc acgaccctgc
      301 aagaacatac ggcgcagtga agtacctgaa cctttcggag caaccaggat tacgtctaca
      361 tcagcaggag ggatgatgtt tgtacgttct ttgtaagtga taccgaatcc gtgagagaaa
      421 tacaaagcct tacccggagt caggtatttt ttgatgcgcg gccaaacttc aatctgagca
      481 gcatctgaaa gcagatactg gatgatagtt gctttttcgc atgcttcttc gatatcgaac
      541 agtgtttcgc ccggtaccca accgtcagca acggcctttt cccaggtctt accaccttta
      601 cgttgtccta caattacgtt aaaaccattg tcgcgcaggt tcaggctctg gccaggacct
      661 tgtacgccgt aacctattac agcgattgtt tcgtctttca atacttctct tgccttttcc
      721 aacggaaatt cttcgcgggt tactacgttt tcgtcaacgc cgccaaaatt cattactgcc
      781 attttctttt tactattaaa atgtatataa aataatttgt ttttcagatc caggtaacgg
      841 cagcgcggct gatggctttg ccgtcgttac agattgccat attatattta ccgggggata
      901 cttcctggtt atggagagtc agctccatcc catactttcc ttcggactga taagctattt
      961 cgaaacggct tatctctttt tctcggaaca ggctgatatc gaacaagtcg agcaggtgtt
     1021 ccatgtattt gatactgttc aggtggccgt ttacgtccag gtcactgtac ttcacacggt
     1081 aaggttcgcc ggaagtgttg ttttccaccg gagcaatttt acccggtttt tcgatcggac
     1141 agggacggtc ggtgatataa gcactcaggc cctccacatc gagcaaggtc gggcggcggg
     1201 tttccatatc gatagccgcc cagatagagc gggcaaagcc aaaggtcttg ccttcgccgt
     1261 tcaccagttc aaagcaacgg ctggtaaaca acttaccgac ctcatccacc caggtatata
     1321 aagttacgga ttcagacatg gcaggataag aagtcatctc gatagccaga cgggaaagaa
     1381 cccaggcggt atgcctttcg gtcatatcgt tatatccgaa tccacggtcg gcggcatggc
     1441 aagaagcagc atgcaacaaa taagttccga tcatagggat tgtaatacgt ccccggaagt
     1501 ccatcagata agactctgtt acgaaatgaa attctcctac tttgttcttc tccataattt
     1561 actttattta caaaatgttt ccttattatt ctcagacatg tttttcctgc aacttctttt
     1621 ccattgcaga taacatgtcg ctcagacgtt ctaccttact cttcgttata gcaacgcgtc
     1681 cggaacggat aaattgcagg acaccgatcg tctcactcaa ttctttaaac aaagcctgtg
     1741 tctcatcata atgaccactc ttttccaaca ccacacaatc ctcattcatt tcaaggatac
     1801 gggcattgta cttacggatc agatcctcaa ccgtccccat cttgataaag agttcggtac
     1861 tcagtttata aagagcgatt tcctggtaaa ccaggtcttc atccgtatta taataggctt
     1921 tcaggatatc cacacgcttg tcgatctgtt ttacgacctt gtcgatcgta tcctcgtcgg
     1981 caaaggtagt aattgtaaac ttatgtattc cctttatagc agagggagaa acagaaagcg
     2041 tctcaatgtt cagttgccgg cgcgtaaaga taacagttat ctgattcaga agaccaacag
     2101 tgttttccga aaagataata acggtatata attgttttgt attcatagtt tctcctcctt
     2161 acttatcacc caaaatcatg tttgtcacgc ttcctccggc cggaaccatc ggatatacca
     2221 taccacaagt ttccacattg gcaaccaaca tataggcacc atcgtgattc aacatttcag
     2281 caatcgcctc atccaagtct tcccgtttat ctaccgcacg ggaagcaata ccaaaagcct
     2341 tggctatcgc tacaaaatcc ggattcttca tgatggtatt cgaataccgt tcgttgaaga
     2401 acagctcctg ccactggcgt accattccca ggaaattgtt gttaagaacg atgatcttta
     2461 cattcagatt ttcctgcatg atagttccca actcctggat agtcatctgg ataccaccgt
     2521 cgccggtaaa gaaacagacc gtacggtcag gcgctcccag cttcgctcca atggcggcgg
     2581 gaaggccaaa gcccatcgtt cccaaacctc ctgaagtaac tacgctgcgt gtttgtttat
     2641 atttgaaata gcgaacaccc atcatctggt tctgacctac atccgtaacc agaatcgcat
     2701 cattatcggt tgcttcggaa accttacgga ctacctcgcc cattttcagt tggccttcgg
     2761 taggatagag ttctttttct attaccttat tatattcctc tttttcatcc ggttcgaatt
     2821 cagcattcca ttccggacgc ttccgttctt ccagtaaagc cgtaatcatc ggaatcgtat
     2881 gcttggcatt tcccagcact ttcacgtcga ccggcacatt ctttccgatc tccgaattgt
     2941 cgatatccag gtggataatc tttgcctgct tggcataagt cttcaggtcg ccggttacgc
     3001 gatcatcgaa acgcataccg atagcaatca gcacgtcaca ttcgtttgtc ttgcggttcg
     3061 gtccgacatt tccatgcatc cccaacatac ctttatttaa tgggaagtcc gaaggtaatg
     3121 cagacaagcc caatacggta gaaccggctg gtatatcgtt tttcaacaag aattctttca
     3181 gttcttcttc agctcctccc aggataaccc cctgccctac cagacagaat ggctttttgg
     3241 cattatttat caatgaagca gccgcctcga tacgttcctc cctgatatcc ggttcaggtt
     3301 ggtaactacg aacataatcc actttctgat actcataatc taccaaaccc acctgtgcat
     3361 ctttcgccag atccagtacc acaggtcccg ggcgaccggt cgatgcgata tagaaagcac
     3421 gggaaacggc ccaagcaatt tcttccgggc ggcgtatctg gtaagcccat ttggtaatcg
     3481 gttgtgtgat accgatcaca tcaacttcct ggaaagcatc tgttccaagc agcggagacg
     3541 gaacctggcc ggcaatcacc accatcggtg tactgtccat cagcgcatcg gcaataccag
     3601 tgatggtatt ggttgccccg ggacccgaag taaccaccgt tactcccact tttccggaaa
     3661 cacgggcata tccctgtgca gcatgtgttg caccttgttc gtggcgcacc agaatatgtt
     3721 ttaactgatc tctgtaatcg tataaactat cgtaaattgg tatcgcctgc ccacccggat
     3781 aaccgaagat agtatctact ccttcagcga tcagcgcttt cagcaaagct tccgaaccgg
     3841 ttatcttttg ttccatattt gttgttttat tgtccctttc ccctcttgag agggggtagg
     3901 gggtgtgtta atgctatcct atagagctga actttaacac accccttatc ccctctcaag
     3961 aggggaaaga atactctttg ttactaatta atcttctact attcgtacac cgcccttatc
     4021 ggccgaagca accatctttg catatgcttt cagtgctttc gataccgtac gttggcggaa
     4081 aggaggtgta aaggcttttg ttccgcgggc ttcttccgct tcacggcgtt tggccagttc
     4141 ttcgtctgtc acctttacat gtatggttct ttcgggaata ttaatttcga taatatcgcc
     4201 gtctttcact aagccaatcg ctccgcctgc agccgcttcg ggagaaatat gtccgattga
     4261 caaacccgat gttccaccgc tgaagcgtcc gtctgtgatt aacgcacatt ctttacccag
     4321 atgtttactc tttatataag aggtaggata caacatttcc tgcatacccg gaccaccctt
     4381 aggaccttca taggtgataa cgacgacatc gccggagacg acttgatctt tcaggatacc
     4441 ttcgcaagcg gcatcctgcg aatcgaatac tttggcaggg ccggcaaaac ggaagatact
     4501 ttcatctacc ccggctgttt taaccacaca accgtcctgt gcaatatttc catacagaac
     4561 agccagaccg ccgtctttca cataagcatg ttccacatcg cggatacatc cggttgcacg
     4621 gtcggtatcc agttctttat aataactttc ctgcgatccg agcaccagat tgaaacggtg
     4681 ggccggagca cttttataaa tattgattgc ttcttccgtt acatttacag aggtaatgca
     4741 gtattggtcg atagcctcat tcaaagtcag accatccgca cgtttcacgg aaccgtccac
     4801 cagaccggct tttaccagct cattcataat accgataata cctccggcac ggttcacatc
     4861 ttccacatga taagaacaac tcggagccac tttacagata accggtgttt tgcgtgaaag
     4921 catatcgatg tctttcattg taaaatcgac ttccgcttca tgagccacgg ccaacaggtg
     4981 aaggactgta ttcgtcgatc cccccatggc aatatccagc gacatagcat tcagaaaggc
     5041 ctgacgggtg gcaatactgc gaggcaatac ggaatcatcg ccgtcacgat aatatttaaa
     5101 ggcattatca acaatcatct tcgcggcttt tttgaacagg cgggtacggt tggcatgtgt
     5161 tgcaacaact gttccgttgc cgggaagagc caatccaatc gcttcgttca gacagttcat
     5221 agagttagcc gtgaacatac cagaacagca accgcaggtc gggcaagcgg aacgttccac
     5281 cttttctact tgttcatcgc tgatagaatc gtcagccgct tcaatcatgg cgtcgatcaa
     5341 atcgagtgca cgtccgtcca gattaccggc ttccatcgga ccgccggata caaagattgt
     5401 cggaatattc agacgcatac tggccatcag catacccgga gtaatcttgt cgcagttact
     5461 gatacaaacc attgcatcag ccttatgcgc attcaccata tattccacac tgtcagcaat
     5521 gatgtcgcgg gaaggcagag aataaagcat tccgtcgtgt cccatagcaa taccgtcatc
     5581 aatagcgatc gtattaaatt ctgcggcaaa gcaaccgagc ttttcgattt ccgcttttac
     5641 ctgctgtccg atctcgtgta gatgcacatg gcccggtaca aactgggtaa atgaattcac
     5701 aatggcaatg atcggtttac cgaactgttc ttctttcatg ccgttggcac gccataatgc
     5761 acgggcaccg gccatacgtc tgccttctgt gctataggag cttcttaacg gattcttcat
     5821 catatctgtt tttatctttt agtcaataaa aaagcccttc tctatatgga gaaaggctta
     5881 agaaatatct tttacgactt cacaacttct tacacacctt tctccttacc tactaatgac
     5941 tagaaggacc accacgagaa taatatgtaa tacattgttc atcatctttt cttatcgtct
     6001 ttattttgtt tgacgctgca aatgtagaat aataatttgt acgagcaaag gatttaaaag
     6061 aaaaatctta ctttttcttt catttatcaa gaaaagaggg cggttcatct tgcattttaa
     6121 cagataacca gccctcaatc aattgaattc ttatttctga gcctccattc gcttcatatt
     6181 cgataatttc cggtcattct cctttactga tacgattgtt cagttctttc aacaaagcat
     6241 acgatttcgg agaaatcgtt ccatcctgat aaatccggac attaatcatc ggaagatttt
     6301 ttcgtttgtt agattctttc actacctgcg tcaattcgtc aatggaaaga acaggatcac
     6361 cgataatgga atctttataa atgtgcgtcc agtcacccgg ctccaatgtt ccggagaaag
     6421 ttgcctgtaa gccatcctga gggccaccgt gaaacaatcc gttcccatcc aacggaagag
     6481 aaggatcgtt aacaccggca ctggccaaag acaaacccag ttcgccagca taataatcct
     6541 gaaagtccgt cagtttcggc aatatccagg aattaaaaca aatcgccaac tccttatttc
     6601 cacttttggc ggctttagca atcttttcaa acgaagcgcc gttaggataa taaccgatac
     6661 cgtcatccat ccacaaaccg gccagacgat ttccataccg ctggctaatc tctcccacta
     6721 tcttttccac atttgtaaac aaatctcctg cattatcacg tgtataatgc tgcttgtccc
     6781 accattcttt atctccatga ccgacatggt aatacagaat cagacgaatg ccgtatttac
     6841 ccaacgcatc agataaatca gccactaaat ctctctttgt ggtacgcccc ggcaaaatag
     6901 aatcgattgc ctgtatcgga gccgggaaat aatattccgc ccacgacgtt gtaaaaaata
     6961 tcaacttccc gccacattcg taaacggttc gtgcaaagcg gtccacatca aagttattga
     7021 ccgcatcctc ataggctaac ggctctcctg actgaggcat actctttgaa ttccagtgga
     7081 agaaaaagcc ataaggcaaa tccgccatcc aggatgtatt actgcgaagt gatgtagctt
     7141 ccgcccgcaa ccgctcataa gtctccggcc gggtgacttc caacgagtac agatacacat
     7201 taaaatcatc ctgcttaccg ggtttgccaa tctttaaaga taaaatggaa gtccccttat
     7261 taaaatgcaa agggcggggg aacctgcaac gctgccatcc ggttgtattt atccggcaaa
     7321 taacactgtc cgttccattg gataatacca actccgtttc ttccccatct cccatccggt
     7381 tgacagaaac gatcatttca gccatgtagt cttcaccgtc cgtattgact ttccaggata
     7441 ttgactgctc gggagttttc cagttctccg cccagaatgc tttataaggt tcttccggat
     7501 aaagttgttt cacaccatta ttcagttctc cacgaaaagg aatcaaccgg tttatgttcg
     7561 ccgaatccag gtttaatgcc gtcagatcaa ccggattact gcaagcggcc aggcacataa
     7621 caaacaaaga caaaaaataa ataaattgct ttttcattcg tattttacgg atataggaag
     7681 ggccaatcca ataataactc agaccggccc ttcatgtatt ctacattaat tatctgtaat
     7741 ccggattctg aggtatgttg ttattcagaa tttcggtatc aggaatcaac caagtattgt
     7801 tgtaagcacc gatagggaca ttcaatctgc tgccacgcgc tttctgtacc ttatcgaatg
     7861 tctgggtacg tttcaaatcg taccaggcaa aaccctcttc atacaattca tgctgacgtt
     7921 ccagcagaac ggcttcacgg aactggtcct gagaaagtcc gctcaagtca ggcacgtttg
     7981 tcgggtcgtt ctggtcgaca cgggcacgtt tacggatagc attgatatat tgataagcac
     8041 cggccggtcc gtttatctca ttttcagctt cggcggcaat cagatacatt tcagccaaac
     8101 gaatcaattg agtctgccag gtcaaaatat tggtattaga tgctggcaac tcctgttcca
     8161 gatactcttc attgatatac ttattataat atgtacgcgc gatgacttta tttcctttcg
     8221 catttacata ttcaggttta attccccatt ctttacgcat atcaccttta tcgaagctgg
     8281 caataaaagc atctgtcgga agatacaagg ctgtctggct gccaatcggt gaagattcat
     8341 tatgcatacc gctatagcta tcgggagcgg aaaacaactg agcccagata gtttcagccg
     8401 tataacgttc cgtcttaaag actttatcga aggtaggcat caaagaatac tgaccgctgt
     8461 tgattacttc aagcgctttc tctttggctt tcgcataatt ttctttctga ttcatcggga
     8521 agccggcaga agtcagatag atacgtgcca taatcgcttt tacgacccat ttatttacac
     8581 gtcccatatc ctgcgcttct tccggaagtt tttgttccgc atccagaata tcgtcaaaaa
     8641 taaactgata gatatcagcc tgcggcatac ggtctattgc cacgtcggca tcactggtca
     8701 cgactttatc ccgcaaaggg acatctccaa agaactggac caatgtaaaa taagaccagg
     8761 cacgcaaaca tttcgcctca ccgataatac gattcttggt ttcggcagta aaatccttat
     8821 cttctatcga ctccaatatc atattcgcat tctttatcgt actgtatggg ccggaccagg
     8881 catttctaaa ggcataaaaa ccatatcccg gattatttgc ccagatatcc ccgacctgtt
     8941 cagccgattc aggcttatca ttatagtcgg caaaaacttc cgtcagattc agattttgtc
     9001 cctgaggata taaccctttc aaagctccgt caaaatcttc caccgtttga tagaaggaag
     9061 agggagaaat aaatgttttc gggtcttctt ccagccaatc ggagcaagaa gcagacagaa
     9121 taaccggtac agccagcaat atatttttaa tcagtgtttt cattcttttc atacgtatta
     9181 aaatttaacc tgtaaaccca aagtaaatga tttcgcagac gggtaaaccc ctctgtccca
     9241 tccgttcacg gcagaagacg tccaggatgc ttccgggtca taatgagaat agcttgtaat
     9301 cgtaatcaga ttctgtccgc tcagataaac cgagatatta ggtttacggg aacctgcgaa
     9361 ccattgagac ggcaacgtat aagccagttt gatatctttg aatcgcagat acgaaccgtt
     9421 ttccacccaa accgaactcg ggtcaccgaa ggccagataa tccttggtcg caacagaagc
     9481 acgtgcatat ttggcattcg gattttcagg agtccaatgg ttttcccaaa catctttgcg
     9541 gatattccat gtgccaccga tattagtgat acttttatta aattcattaa cgatatcacc
     9601 accaacacta cctattaaca ggaatgataa ctcgaagtta ttccaattga taatattcgt
     9661 cagaccgaaa gtaaacttag gctgcgtatt tgcaataatc gttttatcac ctgttgtaat
     9721 accagctttc ccgtccgtgt ctttataccg gtaatcacct gctttcttgg ttgcttcgcc
     9781 attcaaacga gcttcttcat ccgtctgata aataccttct atttcgtagc catacaattg
     9841 gaacggagct ttaccgacaa acagagggaa ccagtttccg ccaccgatag gagcatctat
     9901 ccgctgaatc ttatttccat acacatccga acccaaatct ttcacgattg atctattgga
     9961 tgtaatattc aaattagtcg tccagttcac ttttcctttc atattgattg tattgataga
    10021 tatttcaaaa cctttattat caatacgtcc taagtttctc agcatagaag aatatccgga
    10081 agacggggga agagtcgcat tatacagcaa gtcacgcgtt tgtttccaat aatagtcaaa
    10141 accgatattc aggcggttgg aaaagaatcc aaagtcgaca cctatatccg tttgtgtagt
    10201 tgtttcccat ttcaagtcgt cgtttgccat ggaggacaaa ccgaaaccaa tatcttttcc
    10261 atcaccgaaa ataggaccgg aagttcccag acgggcgaaa gtctgatacg ggctaataga
    10321 ttgattaccg gtctgtccga tactggcacg cagtttcaga ttgctcagcc aatcaatatc
    10381 ttgcataaaa ttctcttccg acaaacgcca ggccaatgcg gcggaaggga agaaagcgaa
    10441 tttatggttc ttactgaatt tagacgaacc gtcatatcgt gcggtgacag tcaacagata
    10501 tctttccatc aggttataat tggcacgtcc caggaaagaa gccatccggt aatcgctgta
    10561 accggaagac ggagttccgg gtgtagaggc tactcccaaa ttattcgttt catagacatc
    10621 gcgcagaaat cctgtacctg agccgcccaa atcattatac tgataggtct ggaaagtaac
    10681 accacccatc aggttcaatg catgattctt attgaaccgc ttgtcgtagg tcaaaatatt
    10741 ctcattaata atagtataat aattagattt tgacttagac gcatcaccat ccaatttacc
    10801 tccggcagac aaaccaatcg gaatgtaccg gtcggaacta cccgcattga cttcagcacc
    10861 ggcattcacc cggaaagtca atccgtcgat aatctcatag ataagcgaca tattcgccag
    10921 taagcgggaa ttaacggttt tattcttata caattcagcc ataccgacag ggtttgttcc
    10981 tccccaggga gttcccgaga aattggtgta cttgccatcg gcatctctta tttcctgtat
    11041 cggagccatg accattgccg tataagcaat cgctccccag ccatccgcat tactgttcgc
    11101 tgtattctga gttccgtatg aataagcaat actggcattc aacgacaaat ttctcgccag
    11161 cttctggtcg ccattaatac gcaatgcaaa acggttataa tcagaacctt tgataatacc
    11221 ttcctggttc atatagttca gagaggagta caacttcgtt ttatccgtac cgcccgagac
    11281 agacacctga tgactatgcg tcaaggcagt ctgataagcc aggtcctgcc agtcattgtt
    11341 cggtagcaga gctgcttgct ccgatgtgat ggcaataccg ttcccgtcat tttgggaaac
    11401 ttcatttacc atggcgatat aatcatcttt tcccagtaaa tccagtttct ttcttaaaga
    11461 agaaacaccg acatatccat tatattcaag gaccgtatcg ccggtacgtc ctcttttcgt
    11521 cgtaatcata acgacaccgt tcgcaccacg tgaaccgtag atagccgtag aagatgcatc
    11581 tttcaatact tccatcgaca gaatgtcttc cgggttaata tccgaattca tcttttctac
    11641 cggcataccg tcaatgacat aaagcggttc gttaccacca gccagggagt tacttccacg
    11701 gacacgaatc atcattgatt cacccggctg accggttctg gcattaacct gcacaccggc
    11761 tatttgtccc tgcaacgcac ggtcggcact ggttataccc acctggctca cgtccttcat
    11821 ctgcacggaa ccgacagctc ccgtcaggtc gctcttcttt accgtaccat aaccgataac
    11881 cacaacctca tccaaggctt cggaatcctc gcgaagtgaa acatttacga catctccgct
    11941 tccgaccttt acttcctggg tgttgtaacc gatataagat atctgcaaca caccaccttc
    12001 cggaacttcc agactatacc gcccgttcat atccgtaact gtcccgttcg ttgttccctt
    12061 tacgactaca ttcgcaccaa taacgggttc accggtttca tccttcacaa ctcctgatat
    12121 atttttcgtt gaagaaacag tccgggcttg cttgttgata ataatatgtc cgttactgaa
    12181 cgttatcgaa caaccggaac cttccagcaa ctgttccata acctctttca cattactgtt
    12241 ctttggtaac tttgtcagga cgcgggaatc gtttacttcc tgcgtgttat aatcgacaaa
    12301 cagtttggtc tgttgttcga tttgtttgaa ggctgtcttc agtgttacat tgcttccggt
    12361 caggcgcact tgttgatgtt gcgcataaga aaataaactg atggaagata aagctgtaat
    12421 aaacaacagc ctggatacac tttttccgtt atttatacgt attagattag ttaatttcat
    12481 atatttgtac atttgaaaat tgaatattaa taaaaccatg acgatttact cgtcaatcca
    12541 atgatgttca agattcgatt tcgaattccg gaaagaggga ttttcgcact ttctgtcttt
    12601 ccggttttct tttgttcata tttgtttact cctatatttt agtttataaa taccaccttt
    12661 ccttttattt tataatgtat accaatcagt tgttgcagaa tgttcagcac atcttccagc
    12721 ttttcatccg gcgagaattt gacattataa tattctcccg caaacttttg ggaattataa
    12781 tgaatcgtca cattgaactt acgttccaaa gaggccatca gacggctgaa agatgtattt
    12841 tcaaatatca gatagccgtt tctttccata ttatataagg aagcgtcgat agaatggacc
    12901 atcacggtat gttccgaatg cgaataaacc aactgttgat caggctttaa cacggtcggc
    12961 tgaatatcct cattcctgac ggataccagt acacttcctt cctccaatgt tgccatggaa
    13021 caggagtcac ccggataagc ctccacggta aagacagtac ccaacgcctg gacatcgagg
    13081 taagtcgtct tcacaacaaa gggttgctcc ggattcttac ggacagagaa ggatgcttgc
    13141 ccggtcaggt aaaccgttcg tgtatcagta tcggtaaaat ctttcggata aaccaacagc
    13201 gtaccggcat ctacccacac cttcgaaccg tcaggcaata ccacctgctc actttctccg
    13261 taagggacga atacctgtgc catttccaca tgacggaccg gtttaaaacg gtcggttgcc
    13321 caataggtcg ttccggcagt catcatcatc aagacaataa cggccgcata tttcaaccac
    13381 tggcgataga atggcaccga acgttcacga acggggagca cggaaagatg cctttgcaaa
    13441 gccttccaat cactatgggt agaatccgtc acctccggct gagatttctt ccacaaatcc
    13501 tgcaacattt cttccttctc cgtttttgca tcgtccgcct tcaaccaacg cccaaacaag
    13561 atacgtccat atcgggaaaa gtgctttccg aagtagagct gcatgagttg ttttatcttg
    13621 ttgttctctt ccataaaata tccgtcttta tatggatgta ggtttatcac aacaatacac
    13681 acaatctaaa atcaactttt tttgaaaata gtttgattcc ggtactaacg ggtgctatcg
    13741 ttgaatgtgt ttcatactaa tgaaactgtt gtttctatat gatggaacac ttgtttcatt
    13801 aagatgaaac acttttgggg aacggcagtg ctcagcccaa acaggtaaac aaaaaaagat
    13861 aaagaacctt acgaagaatg gacagggcgg cagtcaaatg gttttcgact gtacgtttac
    13921 tgattcccaa acgggtggcg atctcatcat tcgataaacc ctgctcacga ctcatcttat
    13981 aaattagctt tcgttgagga gacatttgtt cgacagtccg gttgataagg ttttgcaatt
    14041 cacgtgcaaa catcgcttcc tcttccgatt gggagatgga ggcttccagt aaaaactcat
    14101 tggtatactt ttctgaaacg gcaagacggt cgaaataatc ataaacggta aagcgcgcca
    14161 tctgaaagag ataggaggaa aaagaacgga cgtctctcag tttttcccgg tctttccata
    14221 tggaaagaaa caaatcctgg gatatatcac gactgatttc cttgtcgtgc gtcaggccga
    14281 caaggaaata taccaaccta ggttggtagt cgaaaaaaag ctgttcaaaa gcttttatgt
    14341 ttcctcttgc gatctccctc aagatatgtt gctcctctgg taattccata actagtgcga
    14401 agtaacaaaa aatatcagaa ataaaattat ttactttgat aaattcatag aaaacacggg
    14461 aacataaact acctttgtct tatctcgtaa gcataaataa aaaacaggag taattattat
    14521 ggaagttgca aaaagaatcc cttacggcat ttccaatttt gtggaagtgg tggagcagaa
    14581 ccagtattat gtggataaga cgatgtattt gcctatgctg gaagagcaac ccagtaattt
    14641 gtttttcatc cggccccggc gttttggcaa gagcatcttt ctgagtatgc tccgggccta
    14701 ttatgatatt gctcaaaaag agaagtttca aaaacgtttc ggcaatttgt ggataggaga
    14761 gcatcccacc cctttacaag gaacatttca agtactttat ttggatttct cacgtgccag
    14821 tggcggcagt ggttcactat cagagaactt tgaccggtat tgcagtatgg tgatggatat
    14881 gttcggcatg tcttacgagt cttattatta tccggggttt gccaatgaaa tgaaagcatt
    14941 gcccgatttt gtcagcaaac tgaactattt gaatcttcat gcacccgaaa ccggggcgca
    15001 tctctatctt attatcgacg aatatgataa cttcaccaat ataatactca atgagcaagg
    15061 taatgacgtt taccatgctc tcacacatgc cagcgagttc tatcgcgaga ttttaaagaa
    15121 atttaaagga atgttcgaac gtatcttcat gaccggcgtc agtcctgtta cgttagacga
    15181 tcttaccagc ggatttaata tcggctggaa catcagcacc gaacatcaat tcaatatgat
    15241 gctaggattc agtgaagtag acgtacgctc tatgttccag tattataagg atgcaggaca
    15301 actgtcggat gatgcagata tagaggcaat gattacggag atgaaaccgt ggtatgacaa
    15361 ttattgtttt gcaaaagaaa gcctgaaaag tgacccgaag atgttcaatt gcgacatggt
    15421 actctactat ctccgcaatt acataacctt gaaaaaatct cccgaacaga tgatagaccc
    15481 caatacccgt acggattata acaaaatgaa gaaactcatc cagctggacc gtctggacgg
    15541 tgaccgcaaa ggggtactgc gtaaaatcac tgatgaagga caaatcgtta ctaatctggc
    15601 aatcactttt cctgcaacag agattgccaa tccggaaatc ttccccagtc tgctttttta
    15661 ttatggtatg ctgactatta ccgatacccg cggggggcgt gtggtattaa gtatccccaa
    15721 caacaatgtg cgcaagcaat attacgaatt cctgttagag gaataccaaa ataaacgata
    15781 tatcaatttg aaccagttga cagatctgtt cgatgatatg gcc
//
