LOCUS       gnlProkkaLDBCMDFM_46   13626 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LDBCMDFM_46.
ACCESSION   gnlProkkaLDBCMDFM_46
VERSION     gnlProkkaLDBCMDFM_46
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 05:07:10
            Original ID  :: gnl|Prokka|LDBCMDFM_46
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 28962
            Orig. end    :: 42588
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13626
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10351]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10351
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13626
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13626
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2127..3161
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_18"
                     /sec_met_domain="PF04055 (E-value: 4.1e-18, bitscore: 57.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYPLLGMTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDD
                     MTNLSLKHRELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATL
                     CVSSQVGCKMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALELLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAE
                     LMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRV
                     NLIRFHAIPGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEK
                     NNES"
     CDS             3180..4220
                     /locus_tag="ctg46_19"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKE
                     AEQTNK"
     CDS             4225..5319
                     /locus_tag="ctg46_20"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5329..6570
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.1; E-value:
                     2.5e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg46_21"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQSSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             6557..7084
                     /locus_tag="ctg46_22"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             7090..7863
                     /locus_tag="ctg46_23"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQPAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             7870..8265
                     /locus_tag="ctg46_24"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             8515..9903
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg46_25"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             10001..10351
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_26"
                     /sec_met_domain="PF05402 (E-value: 2.6e-17, bitscore: 53.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 6.8e-11, bitscore:
                     32.8, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRLKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYELRVSAYLSQMQ
                     KDGFIKLVIPVV"
     CDS             complement(10370..10654)
                     /locus_tag="ctg46_27"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(10691..11758)
                     /locus_tag="ctg46_28"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSAGKKAAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKMPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(11831..13342)
                     /locus_tag="ctg46_29"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
ORIGIN
        1 cgcccatttc cagttgaatg gcttttcaca ggcggatgcc aagtcgttct caaagcaata
       61 tttgtctact tactccaagg ctttgtctgc acaacaggaa gatattcttg cttcgtgggt
      121 gctggctaaa caaccgcgct gtttaagtgt attgctcaac gagctggttt cgttcggtca
      181 gtacgatgct ctcaatgaat atatgagtgg atattgccgg ctcaatgagg ttgggcaatt
      241 ctatgacagt gtgttacggc gtttgtcggc tgattatggt ttcgaagaga ttggaagaac
      301 gcttctgatg ctttcactta ctttagaagg atttaccgaa gatgaagtga agagcatggc
      361 agacattaat cagatacttt ggtcgcagtt gagagtggaa atgagcagct ggctcaccaa
      421 caaaggaggg cgatattgca ttggtgacac acaaatggta gaggcaatcg aacgctattt
      481 cgctcaagat gacgaatgta tagatgatag tcgccatgaa attatttccg ctctgctgga
      541 tgaggaagaa atcctttccc atccgttgac ttttgccgat tataactatc gcatgaaaca
      601 gttctgctac catgattcgt atcgttataa agtggagatt acctatcaat gctataagat
      661 gcaagaatgg gatatattga aggattggat ttgtgatgtg gagattttcg agattctgta
      721 tcgcacgaat cgttctctgt tggaagatag ctggaaggcg atcatgaacg acaatcctga
      781 agttacgcct gaagtctatg ccgaattgga ctttgatgag atcgattctt ttttaattcc
      841 tgtcattgct aatgatatgg ctactttctt gagcagttct ttccatctga cgaaggcggc
      901 agctgctgtg agtgagaaga gtatggaagg tgctgccatg ccactcattg ccaagtcggt
      961 attgaagatg aatgagggat gccggtatgc ccgtaatgaa gaatacgaaa cggcatgcga
     1021 ctgtttcttg aaagcattgg tgatgcagga aaacattgta ccgactccgg aactggagat
     1081 tgccaacacc tgccgaaatc tagctctggc atattactac aatgagcaat acaatgaagc
     1141 ggcgatctat ttgaataggg cgcttgatta tcatgcggct tctgctgacg agaagagtca
     1201 ggcagaagtc attgaacttt ccgaatatct ggcttattgt gattactata aggatgagga
     1261 agagagtgct gccgagaaat tccggaaagt agctgaaatg cacgagtcat tgaatggcag
     1321 actgtccggt ggagtggcta aatgtttgcg tatgcagggt aaatgtcttt attatatcaa
     1381 acgatacgat gaagcatgga tgctgatgaa tcaggcgttg gacattgcta tacagataga
     1441 tagcaaaaaa cagatcgtcg cttgtcataa acagttgtat tatctgtgca gggaattcaa
     1501 acggatgatg aatgaacgtg gcgatgagca ggcgtctact ttattcttcc gtgagtctct
     1561 tctgcatgaa atgtatttca gcgaaaaacc gcgtctggcg gaattgactg tccgctacga
     1621 ggcattgaga tgtgatatta tgcagcagta ttacatgaat aaagactatg ataacgtgat
     1681 tcgtattgca acgtctttgg attttcacga tgatactgac cctaatgctt cctgtctggt
     1741 atattattac aaagcacagg cttatgtgaa gttggagaat tatccaatgg cgaaagaggc
     1801 tttcttcaga gagcttgaac tgcgaaagaa atatctggga tgggaggatg aagatacgat
     1861 tctggcttgt cagaacctag gggttttgca cagcttttgt aatgaacggg aagaggcgct
     1921 ggcttgtttc cgtgaggcgt acggtcatga agtgaaaaag aatggcgagg attctgaaat
     1981 ggcgcaaaag ctacttcaat atatcagcgt ggttgaatca taacggaggc atactttcct
     2041 tttttgttaa cttttacatt cctgctatac ggaaatcgac tttatttcct tacatttgca
     2101 gatataaact atcaacagaa agaagaatgt ctaaatatcc ccttttagga atgactcttg
     2161 tagagcttca atcattgaca aaaagactgg gtatgcccgg ctttgctgcc aagcagattg
     2221 catcctggct ttacgaaaag aaggtagcct cgattgatga tatgactaat ttgtcattga
     2281 aacaccggga gttgctcaag cagaactatg aggtgggagc ggaagctccg gtagatgaaa
     2341 tgcgctctgt agatggtacg gtgaagtatc tttataaagt gggtgagaac cattttgtag
     2401 agtcggttta tataccggat gatgaccggg caacgttgtg cgtgtcgtca caagtgggct
     2461 gcaagatgaa ctgtaagttc tgtatgaccg gcaaacaggg gtataccgct aacctgaccg
     2521 ccagccagat cataaaccag attcattcgc tgccggaacg ggacaaactg actaatgtcg
     2581 taatgatggg aatgggcgag ccgctcgata acctggatga ggtattgaag gcattggaac
     2641 tactgaccgc tacctacggt tacgcatgga gtccgaagcg tatcacgctt tctactgtcg
     2701 ggctacggaa aggattgcag cgctttatcg aagaaaatga ctgccacctt gccatcagcc
     2761 ttcactctcc gctgaccgtt cagcgtgctg aattaatgcc ggcggaaaag gcgttttcaa
     2821 tcaccgaaat ggtggaactg ttaaaaaact atgattttag taaacaacgt cgactttcgt
     2881 ttgaatatat tgtttttaaa gggctcaatg attcgcaggt ctatgccaaa gagttgctga
     2941 aacttcttcg cgggctggat tgcagggtga atctgattcg ttttcatgcc ataccggggg
     3001 tagacctcga gggggcggac atggatacga tgacccgttt tcgtgattat ctgacgtcac
     3061 acggactttt caccactatc cgttcatcca gaggcgaaga tatttttgcc gcttgcggta
     3121 tgctgtcgac agcgaaacag gagaaaaata atgaaagtta atatataaaa ccgaacatca
     3181 tgaaaaagta ctcttttatt ttatgcatcg ctttggtagc ctttgtcgtt gcatcttgtg
     3241 gtctgaaagg aaatcacacc tctagtggtc gtgcttacga gcttttggtt gtagtagatc
     3301 acggtgtttg ggatcgtgct gccggaaggg ctttacatga tgcgctcgat gctgatatgc
     3361 ccggtttgcc gcagtcggaa ccttctttcc ggattatgta tacttcaccg aaagattatg
     3421 attctacgct gaagttgata cgtaacatta ttattgtaga tatacaggat atatatacga
     3481 aagcctcgtt caaatatgcg aaggacgtgt atgccaatcc gcagatgata ttgactatcc
     3541 aggctccgaa cgaagaagag tttgagaagt ttgtggaaga gaacaaaaag acgattgtcg
     3601 acttctttac ccgtgcggaa atgaaccgtc agattacgtt cctggaaggg aaacacagta
     3661 atttcatttc gcagaaagtg gacagtttgt tcggatgcga catctgggtg gatgccgaac
     3721 tggctaattc aaagaccggg gatgatttct tttgggcttc taccaacaca ggtactgctg
     3781 accgtaactt tgtgatgtac tcttatccgt acactgacaa ggatacgttt accaaagaat
     3841 attttgtgca caaacgtgac tccgtgatga aagccaatat ccccggattc aaggaaggcg
     3901 tttatatgtc gaccgatagt ttgctgaccg atgtccgtcc gatcaatgta cagaacagct
     3961 acacaatgga agcacgtggc ctgtggcgta tgaagggcga ctttatgggt ggtccgtatg
     4021 tgtctcatac tcgtctggac gagaaaaacc aacgaattat tacagcagaa atatttgttt
     4081 attcacctga taaaatgaaa cgcaacctgg tacgccagat ggaagcatct ctgtatacac
     4141 tgaaacttcc gaatgaagtt cagcagaagc agattccatt gggagaggca tctaaggaag
     4201 cggaacaaac taataaataa aaacatggaa gataacaaga taaggatagg tatcacccaa
     4261 ggagatatta acggggtggg ctatgaggtg attcttaaga cattttccga ccctacgatg
     4321 ttggaactat gtactccgat catttatggc tcaccgaaag tagcggctta tcatcgcaaa
     4381 gcgctggata tacagaccaa tttcagcatt gtcaactctg ctaccgaagc ggggtacaac
     4441 cgtttgagcg tggtgaactg tacggatgat gaggtgaaag tggaattttc caaacccgat
     4501 cccgaagccg gtaaagctgc gttgggggct ttggaacgtg ccatcgaaga atatcgcgaa
     4561 gggttgatag acgttatcgt aacagctccg atcaacaaac atacgattca gtcggaagag
     4621 ttctctttcc ccggacatac ggaatatatc gaagaacgtc tgggcaatgg tgataagtca
     4681 ttgatgattt tgatgaagaa tgatttccgg gtggctttgg tgacgacaca tatccctgtc
     4741 agagagatcg cgactacgat taccaaagaa ctgattcagg agaaactgat gatattccat
     4801 cgttgtctga aacaggattt cggtatcggc gctccgcgta ttgcggtgct ctctctcaat
     4861 cctcatgccg gagacggtgg tttgttggga atggaagagc aggaagtgat tatccctgcc
     4921 atgaaagaaa tggaagaaaa aggaatcctt tgctacggtc cttatgcggc cgatggcttt
     4981 atgggttcgg gcaattatac tcattttgac ggtatcctgg cgatgtatca cgatcaaggg
     5041 ctggctccgt ttaaggcctt ggctatggaa gacggggtga actatacggc aggactgccg
     5101 gtagtacgta cttctccggc tcatggaacg gcatacgata ttgcaggcaa gggagtggct
     5161 tgtgaagatt ctttccgtca ggcaatctat gttgccatcg acgtgttccg taatcgtcag
     5221 cgggaaaaag tggctcgtgc caatccgttg cgtaaacagt attacgagaa acgtgacgat
     5281 agtgataaac tgaagctgga tacagtagac gaagattaaa aacgagtgat gacgaaagca
     5341 gagatacaac aagtgaaaca gcgtttcggt attattggaa atactgaagc attgtcgcgc
     5401 gccatagatg ttgccattca ggtagctcct accgatttgt ctgtgctgat taccggagaa
     5461 agtggagtcg gaaaagaaag ttttccgcag attattcatc aatatagccg gaggaagcac
     5521 ggacagtata ttgctgtcaa ctgtggcgct attccggaag gtacgattga ttccgaactg
     5581 ttcggacatg agaaaggtgc gtttaccggt gcgattggcg aacggaaagg gtactttggc
     5641 gaagccgacg gcggtactat ttttcttgat gaagtagggg agttgccgat gtctacccag
     5701 gcacgtttgc tccgtgtact ggagagtggc gagtttatga aagtaggttc gtccaaagta
     5761 caaaaaacgg atgtgcgtgt ggtggcggct accaatgtca atctgacaca agcgattgca
     5821 gaaggacgtt tccgtgaaga tttatattac cggttgaata cggtgcctat ccaaataccg
     5881 cctttgcgtg aacgtggtga cgatgtactt ttgttgttcc gtaagttttc cgcagacttt
     5941 gcagagaaat accggatgcc tgctattcag ttgacggagg atgcgaagaa agagttgttg
     6001 gcttacccgt ggcccggaaa cgtgcgccag ttgaagaaca tcaccgagca aatatctatc
     6061 attgaaacca acagggagat ctctgctgct atcttgcaga attatcttcc cgcacaaaat
     6121 acgcaacgtc ttcccgcgct gatgggaacg cgtgagagta aaggctttga gagcgaacgg
     6181 gagattcttt attctgttct gttcgatatg cgccaggaag tggcggagct gaagaagatg
     6241 gtgcacaacc tgatggcgga acgtgccgga caggtggggc aggtaggaca aatgggaacg
     6301 gtggttacta ctccggtagt gacggcgcat caatcttcgg tacctgctat tattcacacc
     6361 atgcagccca cggtttgcaa ggatgatgat gacatacaag acacggaaga atatgtagaa
     6421 gaatctcctt tgtcactgga cgaagtggag aaagaaatga tacgcaaagc acttgagagg
     6481 catcatggaa agcggaagag tgcggccaag gacttgaata tttccgagcg tacactttat
     6541 agaaaaataa aagaatatga attggattaa gaaaataata cgccctttgt tactgttcgg
     6601 cttgccgttg gtagtcattg cgtgcactgt ttcctataag tttaacggat cgtctatcaa
     6661 ttatgataag gtaaagacca tttcgatagc cgacttcccg atcaagtcgg agtatgtgta
     6721 tgctccgttg gcaaccaagt tcaatgagga cctgaaagat atcttcatcc ggcagactcg
     6781 tctgcaactg ctcaagccga gtcaaaatgc cgacttgcag attgacggag aaatcacagg
     6841 gtacaatcag tacaatcagg cagtatctgc cgacggttat tcttcggaga cgaagttgac
     6901 tatcaccgtc aatgtacgtt ttgtcaacaa caccaatcat gccgaagact ttgaacaaca
     6961 gttttctgcg ttccgtacct acgactctac ccagttgttg actgctgtac aggacggatt
     7021 gattgctgaa atgtctaaag agatcaccga ccaaattttt aatgcaactg tagcaaactg
     7081 gtaatataaa tgacttctgt taactttcaa caatggattc agcatcccga gacgctgaat
     7141 agggatactt tgtacgaact gcgcaatctt cttgcgaggt atccgtattt tcagtcactt
     7201 cgtctgctgt atctgaagaa tctgtatatt ctccatgata ttagttttgg tggagaactg
     7261 cggaaagcag ttctttacat tgcagacaga cggcagttgt tccggttgat tgaaggtgac
     7321 cgctatgatg tgcaagcacg gaaaaaggga gtacctctca cggaggtgct gaaagacgaa
     7381 ccgtccgtag accgcacatt agcattgatc gacgctttct tgtccacagt acccgaagag
     7441 gtgactgccc ggaccagctt cgactattcg atggattaca cctcttatct tttggaggag
     7501 actccggcca cggaacagcc ggccgaagaa acacccaaac tcaaaggcta cgaactgatt
     7561 gacgacttta tagaaaagag cgagagcgac tctcccctct gcaagaaacc tttaagagaa
     7621 gaaatgccat cttcgccaac ctcttcggac gaacttaccg aagaagaaac gatgaaggaa
     7681 gaagaggaag atgacagctg ttttacggaa actttggcaa aaatctatgt taaacagcaa
     7741 cgatattcaa aagctcttga aataattaaa aaattaagct tgaaatatcc aaaaaaaaat
     7801 gcttactttg cagaccaaat cagatttttg gagaaattga ttattaacgc taattcaaaa
     7861 taactaaaaa tgtacttatt attcgttatc ttaatggtta ttgcagcctt gttgatgtgt
     7921 ttcatcgtgc tgattcagaa ctcaaaagga ggcggacttg cttctggttt ctcttcatct
     7981 aacgccatca tgggcgtgcg caagactaca gattttctgg aaaaagcaac atggggctta
     8041 gctatcttca tggtggtaat gagcattgct actgcttatg tagttcctcg ctctgctgtt
     8101 gctaaagacg cagtgttgga acaggcacag aaagaacaac agactaaccc gtataactta
     8161 cccgcaggta cggctgcgcc gcaaactgaa gctcctgcta ccaatgcacc tgctacagaa
     8221 actccggcac cggctactga aactcctgct cctgcagcag agtaattcac tccgttgtca
     8281 ggtaagactt tggggtaaaa ccattaatgg gaaggtgcag acggatgctg catttctttg
     8341 atatttaagt gcggattacg cagattacac ggattttcaa tcttccgcgt ggtcagtgta
     8401 atccgcactt aactttttct tgtaaaaaca atctcttttt gatagaaaca aacgagattt
     8461 aactaccttt gttggtcgta tgaagattat taactactat tttttaatat aacaatgaca
     8521 gaacatttga aacagaaatt gaatgactcc gccgtactcc gatggagtgt tctagcattg
     8581 gtcgcattta ctatgctatg cggctatttc ctcactgacg taatgtctcc tctaaaaccc
     8641 atgcttgaga aagaactact atgggacagt cttgattatg gtttcttcac aagcgcttac
     8701 gggtggttta atgtattcct attgatgctg atcttcggtg gtatcatttt ggataagatg
     8761 ggagttcgtt tcaccggaat gggggcttgc ttattgatgg tgtttggttg tggattgaaa
     8821 tactatgcga tttctactac ttttccggaa ggtgccatgc tcttcggatt caaaacacag
     8881 gtaaccctgg ctgcattggg gtatgctatc ttcggtgtag gtgtggaaat tgccggtatc
     8941 acagtttcca aaattatcgt gaaatggttc aagggtaagg aaatggcatt ggctatggga
     9001 cttgaaatgg ctacggcacg tatcggaaca actctggcaa tggtgctcac ggttcctttg
     9061 gccgactttt tcggatctac ggatgagagt ggcacattcc ataccaatat tcctgctccg
     9121 attttgtttt gtctgattat gttgtgcgtg ggtacgattg ctttcttcct ttatactttc
     9181 tatgataaga agttggatgc ttctttggat gcagagggat tggaaccgga agagccgttc
     9241 cgtatgaaag atattgtgta tatcattacg aataagggat tctggttgat tgcattacta
     9301 tgtgtattgt tctactcggc tgtattcccc tttatcaagt atgctgccga cttgatggtg
     9361 cagaagtata atgtagatcc gaagttggcg ggaacgattc ccggattgtt gccgattggt
     9421 gcgattatcc tgactccgtt gttcggctcg ctttatgacc gtattggtaa gggagccaca
     9481 ttgatgataa tcggatcagt gatgcttatt tttgtgcata cgatgtttgc tctgcctata
     9541 ctgaatatat ggtggtttgc tactatcatc atgattatat tgggatttgc cttctcgttg
     9601 gtgccttcag ctatgtggcc gtctgttccg aagattattc cggaaaaaca gttgggtacc
     9661 gcatatgcat tgattttctg ggtacagaac tggggattga tgggtgttcc tttgttgatc
     9721 ggatgggtgt tgaatactta ttgcaaaggt ccggtagtag acggtgcaca gacttatgat
     9781 tacacgttgc cgatggctat ttttgctctc tttggtgtgc ttgctctgat tgtggctttg
     9841 atgttgaagg cagagaacaa gaagaaggga tacggtttgg aagaggcgaa tatccaaaag
     9901 taactaggaa attcaatacc taaagtaaca aaggaatttt gtatcaaggt gtaaacagaa
     9961 gagtatcagt atgaatactc tgaaataaaa aataagaagt atggctgcca aagagaaaat
    10021 caacctgtta gaggtcattc cctgtcgcag tgaacatatt acagcagaaa gggaagggga
    10081 gacaattgtg ctctcctttc cccgtcttaa atatccgtgg atgcaacgct tccttgtgcc
    10141 aaaaggaatg tcgaaagaac ttcatgtgaa attggaagaa cacggtacag ctgtatggga
    10201 actgatagat ggaaaacgca atgttcgtga gattatagaa aaactcgcag accactttca
    10261 aaatgaagag ggctacgagt tgcgtgtatc ggcttatctt tctcaaatgc agaaagatgg
    10321 atttataaaa ctggtgatac cagtcgtata aataggaact tattattatt tatttgataa
    10381 atacagccca aagtatgacg gcaattgcta tcaggactcc catgataata agcgttcccc
    10441 aaacaaaata attgctgtct ttctctttct ttttctccga gtcgtggatg atacgttcca
    10501 tttcttcagg agtggtgtta ggtagtggat aaggttcgtt tgcacggttt agatgcttca
    10561 acttatcgtt agcacgttca cgacgtaggc gggaagcttc ccgtccctct tttattcggc
    10621 gtatcatgtc gaatgcatgt ccttcaccaa ccatattctt tgttttttag aagttcactt
    10681 ccttgttttt ctatttccct tcttctctgt ccactttgag caatcctccc gtattcggat
    10741 caaaataaac tttgatggta gaattcttgt tgaacaaaac cggagccaga tattctatca
    10801 caccgaattg ggtaatagga agctcacctt cgtaaagttt ctttttaccg tcggtcagtg
    10861 taaccatagc ttgtccgggg acgttgtagg cgattccatc caaatctttc ttcttcttac
    10921 cgtcttcctg tggcatcttg accgatttca ggtctttcag actgatataa aacggagttc
    10981 ctgccaaatc attgttggca actacaccta acttcttcga gaagcggaaa gcaacttcat
    11041 tgttgaattc cttgtcaggg gtaaggcgga cagtgaatgt tctttcttct ttgttgcagg
    11101 tgccggagaa catttgtgtc atggcttctt cctgtgcatt cagattgtcg agcataatct
    11161 taagctgtgc cccatctgaa ggcatattat cagcttgtcc gcgcaataag gcatttttgc
    11221 tttcgcggat attatagatc tctttagcca ccagctcggc catcttggcg gtagagctag
    11281 ccatcagaat ctcttcggtc aggaattcgc gaggattcgc tttcttttgg aggactgcgg
    11341 gggcgggagc agcttttttg cctgcactgc tattgctgta aggaacattg atcgttttca
    11401 caatgccatc ctctgtcagt tccataagcg gtgctactgt cttatccttc aattttacga
    11461 aatacgtagt ttcgctgttg ggcacaccta cggatttcac ttttacgcta gctagttccc
    11521 aatactcttc agggtcggcg gagacgttgg tcagtcgcag gtaacgatca gcatatttgc
    11581 tgaattctcc gggagtatag ttgactttgt tggcttttat ttcaagttct atttgggttt
    11641 tgggaagact gtaaaccact ccatagtctt ttcctcgggt aacccccgtc agtacttcgg
    11701 tttgtgcata ggcggacgtt gtcataagta gtcctgctgc tataatcaac tttttcatat
    11761 tcggttcttt ttaactggtt ttgaaaacaa agttaatgaa gttattgaaa aaagggtaag
    11821 ttcttaactt ttattcgctt acaagtcgcc atgctgtcgg cagacaggtg ataatatcgc
    11881 ttgcgatcat tccgatcatt ccttgcttct tttgagcgac atcgcccgcc agtccgtgaa
    11941 tgtaagtgcc gattttagcg gcttcctcgg tggggtaacc ttgggcaagc agtgccagga
    12001 ttactccggt cagtacgtca ccgctacctc cggttgccat tcccggattt ccggttgggt
    12061 tgaagaaaca tttaccttcg ggggtgatga tggcggagta ggctcctttt aaaataatgt
    12121 gaacatgggc ggcacgggcc agttcgcagg ccttcatcag acgttcgtaa gagtcctggc
    12181 atttgccggt cagacgttcc agttctttcg gatgcggggt gaggatggaa cccttcggta
    12241 ggtgggtaag tgcatgacgg tggttggcga ggatattaag tgcgtcggca tccactacaa
    12301 caggagtctg gcagtgttcc agttgttcca acaaggcagc ttccgtttcc tcgtttcgtc
    12361 ccagtcccgg gccgatgccg actgcttgat agtcgtccgt gtcggtaggt acggcaaaac
    12421 aggtttcgtt gatgtcggtt tctacgattg cttcgggtat ggaggtttgc aagatgtcgt
    12481 tgttgcacat tggcgcatgg acagtcagca accctactcc cgaacggagg caggcgcggg
    12541 cagcgagaac agaggctcct gccattcctt ttgaaccggc aatcaatagt gcatggccga
    12601 agttcccctt gtgggcaaac tgtttgcgtg gcttgatgag tgaacggatt tgctctattt
    12661 ccaacatttc gtagttcgtt tccatctctt caataccgtc ttcgcttaat tggatgtcca
    12721 gcacttccca ttctccgaca aattccgtgt tctctgcgaa aagaaaggcg agcttcggca
    12781 gttgcagact gaaagttacg tcggcacgga taatattagc ttttacgttg aatgtgtttt
    12841 cttctcccat cagtccggaa ggaatgtcga tggctactac catagcaggg gaggaattga
    12901 tgtatttcac tacggcagcg aatccgccgc tcaacggttt gttcagacct gaaccgaata
    12961 atccgtcgat taccagatgg tcgggcgtca ggacgggagg tacgaattgg gtactgattt
    13021 cgtggaattt tacttcttcc atcatttcta ccaattcttt attggtctgg cagtcgggtg
    13081 aaagttctcc tttcgtgttg aagagaaata cctcgatttt atatcctttt tcagccatca
    13141 tgcgggctac ggcgagagcg tctccgccat tattccccgg tccggcaaag atagtgaccg
    13201 gcgtttctgt attccatctg tctgtgatgg cttttgttaa tacggttgct gcacgttcca
    13261 tcagatcgat tgatgcaata ggttcgttct caatggtata agcgtccaat ttcttgatac
    13321 tgctgcttgg aaatattttc attgcgatgt tcttttagtt ttcggattac aaatgtacat
    13381 gattcttctg acttttcccg tttgttgtgg gaagaaaacc ataattgcaa cttttaattc
    13441 atcattagtt ctatctttgg gtcagagaaa tatctgcttt tgaactatta agtgttagaa
    13501 taactccgcc aaaaaataat tcaatgcagc accattatga acttactttt atttctcctg
    13561 aaaaagattt ctggttcttc gtcaaatttg gtggtaatct cttttttatt tcgatggttt
    13621 tcctct
//
