LOCUS       gnlProkkaPPFIPPEA_77    8918 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PPFIPPEA_77.
ACCESSION   gnlProkkaPPFIPPEA_77
VERSION     gnlProkkaPPFIPPEA_77
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 07:42:56
            Original ID  :: gnl|Prokka|PPFIPPEA_77
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 8918
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..4845)
                     /NRPS_PKS="Domain: AMP-binding (20-419). E-value: 2e-104.
                     Score: 341.3. Matches aSDomain:
                     nrpspksdomains_ctg77_1_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (521-585). E-value: 6.5e-12.
                     Score: 37.7. Matches aSDomain:
                     nrpspksdomains_ctg77_1_PP-binding.1"
                     /NRPS_PKS="Domain: Condensation_LCL (597-878). E-value:
                     2.7e-38. Score: 123.5. Matches aSDomain:
                     nrpspksdomains_ctg77_1_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1033-1421). E-value:
                     2.8e-90. Score: 294.7. Matches aSDomain:
                     nrpspksdomains_ctg77_1_AMP-binding.2"
                     /NRPS_PKS="Domain: PP-binding (1530-1591). E-value:
                     8.7e-11. Score: 34.1. Matches aSDomain:
                     nrpspksdomains_ctg77_1_PP-binding.2"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     179.7; E-value: 1.9e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg77_1"
                     /sec_met_domain="AMP-binding (E-value: 7.3e-109, bitscore:
                     352.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.8e-13, bitscore:
                     37.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 4.4e-49, bitscore:
                     155.5, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNINERNNFAFEFRPVTELFEEQVKLHPEKCAVVSGKESFTYAQ
                     LNERANRIANALVEKGVRRETIVGVVLERCCDFYAVRQGILKAGGAFAVATPDYPDDRI
                     RYIFEDSGAPFIITTKEIAEERRELFAKLPCTVLLIEELLENENTENPQVKIGEHDLCY
                     CIYTSGSTGKPKGVLIEHINLANFVNPDPKNAETYGYVSRGSVSLSMAAMTFDVSVLEE
                     FLPLTNGMTAVIASDEEILNPLMLGELIVRNKVDIMTTTPTYLSNMIDLPQLEKAVSQI
                     KVFDVGAEAFPPALYDKIRRVNPDAYIMNGYGPTETTISCTMKVITDSRNITIGTPNGN
                     VKVYIVDKENKILPDGETGELVIAGLGVGRGYMNLPDKTEVVFIDLNGERAYKTGDLAR
                     ISPEGEIEFFGRIDNQIKLRGLRIELGEIEEVINSYEGIITSITLPVDNKFLCCYFMAD
                     RQINTEELSAYASESLAHYMVPEVFVQLEKMPVTQNGKIDKKALPKPVAQPKNLKEPQT
                     PMQKKIFEIVADVVENDFFGTDTSFYRAGLSSISAMKLCILISEEFGVTVKTSDIHENN
                     TVEKLEKYVMLAPKIRTYEKREVYPLTGSQKGIFAECMKNPESTVYNIPFLFELESSVD
                     VQKLSDAISQMIAAHPYLLTKVYLSDSGEMVQKPCEEAFVPEVVRTTNEQFEKIKDELV
                     RPFKLEKGRLFRAGIYVTEDRKYLFTDFHHILADGNSYDIIFEDIDRAYLGEKLEKESY
                     TGFDAALDEEQQMKEGKYKKAEKYYDSIFEGIETESLPLPDCSGKTPERGYLSMPVDTR
                     ESLVLSACEKLGVTPNILFTGVFGILMSRYSNSEESLFATIYNGRNDSRLENTVCMLVK
                     TLPVYCSCDPKVTIQAYMTELSEQILSSMANDIFPFSDICAKYGINSDLVFAYQAELGD
                     DFPIGDTVARGHDLSPDMSKMPLLIQVREYDHKYVLTAEYRSDMYSEAFVRGMLESYEA
                     AMDSLLKAKYISEVSVLSQNGADTIAEFNNTACEYDRSKTIADMFEELVQTIPDHTAVV
                     FKDKKYTYRELDEISDRLGKYIASQGIGSEDVVSILIPRCEYMAIAPMGVIKAGAAYQP
                     LDPTYPRDRLMYMMEDSSAKLLIADRELLPLVNGYKGPVLFTDQIWQLEDRDVVLKKPQ
                     LHDLFILLYTSGSTGVPKGCMLEYGNITAFCHWFKRYYGIDSDSRVAAYASFGFDACMM
                     DIYGAITNGAQLHIIPEEIRLDFIGLQRYFEENGITHSFMTTQVGRQFALEMDCKSLRY
                     LSVGGEKLVPCEPPKDYKFINAYGPTEATIFTTVFEVDKYYPNVPIGKALDNVKLYITD
                     KLGHMLPPGACGELMITGWQVSRGYLNKPEKTAEVYTKNLYDDTPGYEVMYHSGDVARF
                     LPDGNIQSIGRKDSQVKIRGFRIGLSEVEEVIRRYEGIRDATVVAFDDPNGGKYIAAYV
                     VSDSTVDINALNDFIKETKPAYMVPAVTMQIDKIPLNQNQKVNKKALPLPEKKAAEIIK
                     PENEVQQILFDCIAEVLGYTDFGITTDIYEAGLTSITAIKLNILISKAFDIVIKTSDIK
                     NHPTIRMMEEFVKTAGKESKREVQESYPLTNTQEGI"
     protocluster    1..8918
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[0:4845]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..4845
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..8918
                     /SMILES="NC([*])C(=O)NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8918
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /tool="antismash"
     aSDomain        complement(73..255)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg77_1_PP-binding.2"
                     /evalue="8.70E-11"
                     /label="ctg77_1_PP-binding.2"
                     /locus_tag="ctg77_1"
                     /protein_end="1591"
                     /protein_start="1530"
                     /score="34.1"
                     /tool="antismash"
                     /translation="DCIAEVLGYTDFGITTDIYEAGLTSITAIKLNILISKAFDIVIKT
                     SDIKNHPTIRMMEEFV"
     aSModule        complement(73..3054)
                     /complete
                     /domains="nrpspksdomains_ctg77_1_Condensation_LCL.1"
                     /domains="nrpspksdomains_ctg77_1_AMP-binding.2"
                     /domains="nrpspksdomains_ctg77_1_PP-binding.2"
                     /locus_tags="ctg77_1"
                     /monomer_pairings="X -> X"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(553..615)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0012"
                     /evalue="4.10E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg77_1"
                     /protein_end="1431"
                     /protein_start="1410"
                     /score="28.7"
                     /tool="antismash"
                     /translation="IGRKDSQVKIRGFRIGLSEVE"
     aSDomain        complement(583..1746)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg77_1_AMP-binding.2"
                     /evalue="2.80E-90"
                     /label="ctg77_1_AMP-binding.2"
                     /locus_tag="ctg77_1"
                     /protein_end="1421"
                     /protein_start="1033"
                     /score="294.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FEELVQTIPDHTAVVFKDKKYTYRELDEISDRLGKYIASQGIGSE
                     DVVSILIPRCEYMAIAPMGVIKAGAAYQPLDPTYPRDRLMYMMEDSSAKLLIADRELLP
                     LVNGYKGPVLFTDQIWQLEDRDVVLKKPQLHDLFILLYTSGSTGVPKGCMLEYGNITAF
                     CHWFKRYYGIDSDSRVAAYASFGFDACMMDIYGAITNGAQLHIIPEEIRLDFIGLQRYF
                     EENGITHSFMTTQVGRQFALEMDCKSLRYLSVGGEKLVPCEPPKDYKFINAYGPTEATI
                     FTTVFEVDKYYPNVPIGKALDNVKLYITDKLGHMLPPGACGELMITGWQVSRGYLNKPE
                     KTAEVYTKNLYDDTPGYEVMYHSGDVARFLPDGNIQSIGRKDSQVKIR"
     CDS_motif       complement(712..798)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0011"
                     /evalue="1.10E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg77_1"
                     /protein_end="1378"
                     /protein_start="1349"
                     /score="40.2"
                     /tool="antismash"
                     /translation="PPGACGELMITGWQVSRGYLNKPEKTAEV"
     CDS_motif       complement(901..927)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0010"
                     /evalue="4.00E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="ctg77_1"
                     /protein_end="1315"
                     /protein_start="1306"
                     /score="7.1"
                     /tool="antismash"
                     /translation="YGPTEATIF"
     CDS_motif       complement(1279..1329)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0009"
                     /evalue="7.20E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg77_1"
                     /protein_end="1189"
                     /protein_start="1172"
                     /score="21.7"
                     /tool="antismash"
                     /translation="LLYTSGSTGVPKGCMLE"
     CDS_motif       complement(1519..1560)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0008"
                     /evalue="2.90E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg77_1"
                     /protein_end="1109"
                     /protein_start="1095"
                     /score="14.2"
                     /tool="antismash"
                     /translation="MGVIKAGAAYQPLD"
     aSDomain        complement(2212..3054)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg77_1_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.70E-38"
                     /label="ctg77_1_Condensation_LCL.1"
                     /locus_tag="ctg77_1"
                     /protein_end="878"
                     /protein_start="597"
                     /score="123.5"
                     /tool="antismash"
                     /translation="EVYPLTGSQKGIFAECMKNPESTVYNIPFLFELESSVDVQKLSDA
                     ISQMIAAHPYLLTKVYLSDSGEMVQKPCEEAFVPEVVRTTNEQFEKIKDELVRPFKLEK
                     GRLFRAGIYVTEDRKYLFTDFHHILADGNSYDIIFEDIDRAYLGEKLEKESYTGFDAAL
                     DEEQQMKEGKYKKAEKYYDSIFEGIETESLPLPDCSGKTPERGYLSMPVDTRESLVLSA
                     CEKLGVTPNILFTGVFGILMSRYSNSEESLFATIYNGRNDSRLENTVCMLVKTLPVYCS
                     "
     CDS_motif       complement(2617..2682)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0007"
                     /evalue="1.60E-04"
                     /label="C3_LCL_132-143"
                     /locus_tag="ctg77_1"
                     /protein_end="743"
                     /protein_start="721"
                     /score="14.4"
                     /tool="antismash"
                     /translation="FHHILADGNSYDIIFEDIDRAY"
     CDS_motif       complement(2893..2988)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0006"
                     /evalue="4.70E-06"
                     /label="C2_LCL_024-062"
                     /locus_tag="ctg77_1"
                     /protein_end="651"
                     /protein_start="619"
                     /score="19.0"
                     /tool="antismash"
                     /translation="TVYNIPFLFELESSVDVQKLSDAISQMIAAHP"
     aSDomain        complement(3091..3282)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg77_1_PP-binding.1"
                     /evalue="6.50E-12"
                     /label="ctg77_1_PP-binding.1"
                     /locus_tag="ctg77_1"
                     /protein_end="585"
                     /protein_start="521"
                     /score="37.7"
                     /tool="antismash"
                     /translation="KIFEIVADVVENDFFGTDTSFYRAGLSSISAMKLCILISEEFGVT
                     VKTSDIHENNTVEKLEKYV"
     aSModule        complement(3091..4785)
                     /complete
                     /domains="nrpspksdomains_ctg77_1_AMP-binding.1"
                     /domains="nrpspksdomains_ctg77_1_PP-binding.1"
                     /locus_tags="ctg77_1"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(3559..3624)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0005"
                     /evalue="3.00E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg77_1"
                     /protein_end="429"
                     /protein_start="407"
                     /score="32.2"
                     /tool="antismash"
                     /translation="FFGRIDNQIKLRGLRIELGEIE"
     aSDomain        complement(3589..4785)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg77_1_AMP-binding.1"
                     /evalue="2.00E-104"
                     /label="ctg77_1_AMP-binding.1"
                     /locus_tag="ctg77_1"
                     /protein_end="419"
                     /protein_start="20"
                     /score="341.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FEEQVKLHPEKCAVVSGKESFTYAQLNERANRIANALVEKGVRRE
                     TIVGVVLERCCDFYAVRQGILKAGGAFAVATPDYPDDRIRYIFEDSGAPFIITTKEIAE
                     ERRELFAKLPCTVLLIEELLENENTENPQVKIGEHDLCYCIYTSGSTGKPKGVLIEHIN
                     LANFVNPDPKNAETYGYVSRGSVSLSMAAMTFDVSVLEEFLPLTNGMTAVIASDEEILN
                     PLMLGELIVRNKVDIMTTTPTYLSNMIDLPQLEKAVSQIKVFDVGAEAFPPALYDKIRR
                     VNPDAYIMNGYGPTETTISCTMKVITDSRNITIGTPNGNVKVYIVDKENKILPDGETGE
                     LVIAGLGVGRGYMNLPDKTEVVFIDLNGERAYKTGDLARISPEGEIEFFGRIDNQIKLR
                     "
     CDS_motif       complement(3697..3786)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0004"
                     /evalue="9.80E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg77_1"
                     /protein_end="383"
                     /protein_start="353"
                     /score="33.9"
                     /tool="antismash"
                     /translation="PDGETGELVIAGLGVGRGYMNLPDKTEVVF"
     CDS_motif       complement(3883..3912)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0003"
                     /evalue="1.50E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="ctg77_1"
                     /protein_end="321"
                     /protein_start="311"
                     /score="8.3"
                     /tool="antismash"
                     /translation="YGPTETTISC"
     CDS_motif       complement(4303..4362)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0002"
                     /evalue="8.50E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg77_1"
                     /protein_end="181"
                     /protein_start="161"
                     /score="30.6"
                     /tool="antismash"
                     /translation="CYCIYTSGSTGKPKGVLIEH"
     CDS_motif       complement(4570..4596)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0001"
                     /evalue="4.10E-01"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg77_1"
                     /protein_end="92"
                     /protein_start="83"
                     /score="4.8"
                     /tool="antismash"
                     /translation="GILKAGGAF"
     CDS             complement(4859..6604)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 265.5; E-value: 1.3e-80)"
                     /gene_kind="transport"
                     /locus_tag="ctg77_2"
                     /transl_table=11
                     /translation="MEERNNRLLNAKLNKYIVPGIMMSLALQLGNIVDTIFVSNLIGVE
                     AMSAVTLSLPVETIVQLTGYCLGIGGSIAVGNMLGKRDKEGASKLFSATFIVTLVVGII
                     FSICALPAAEPVARLLVSGDGVLTGYTRDYIRVSMLGAPVIGIGLMMVNYLGVENHPEL
                     ASAYLIAANVINLVLDYIFLRYTPLGITGASLSTVLGFLFAMGIFVLYIRSDKRNLHLI
                     LLKPGELGITKEAIITGVPMLIFMAANFVKALGLNTIIMNQLGEEGMAVFTVCDNVLLI
                     VEMLTGGIIGVIPNVAGILFGEKDYVGIRVLCKKMLKYSYILLAVIFVLIMLFTEEITV
                     MFGSGGGELGSHMVQALRIFALCVAPYLWNKFIISYYESIEETAIASFATFLENAVVVL
                     PATLVGILVWKQIDGIGIDGIAVGFVATEIITAVAACIFRKIRHKNTSFYIVPDKNPGI
                     NLDFSIKSTMEEAQTVHKRIIEFCQEQGASKSKANLAAVCAEEMTVNIIRFGGKTSNWI
                     DINLCLEDDLCRLRIRDNGVNFNPLEYQYDSEDFDIHGIELVKKVSKSMDYIRAIDMNN
                     TIISF"
     CDS             complement(6737..8164)
                     /locus_tag="ctg77_3"
                     /transl_table=11
                     /translation="MDSTKPENLISYTNIEVDGIVTFRGNSFRDTPSHGYADMTDFRLD
                     KLWSADTGSLSSGSAVWTGSGWTGQPLMMKWPKEVKAHMNMTEKAKADDELVEVIYACM
                     DGYVYFLDLRTGEKTRDPLYLGYTFKGAGALNPRGYPIMYVGAGYNSNEGTAKVFVVNL
                     LDCSVMYTFGDNDEFSLRGSLSFFDGSALVDAETDTLIYPGENGILYLIRLNTKYDLNS
                     GTLSIDPGRTVKWRYYGTRSSTESFWLGMEDSAAIYKGYIFMTDNGGNLMCLDLNTLQL
                     VWVQDTLDDSNSTPVLEIEKGHLYLYVSTSFRLGWRSYDTATVPVWKIDAETGEIVWHT
                     DYECTTDDGVSGGVQSTIACGKNSLADYIYVTVAKTSDNASGVLACLRKSDGSKAWEDS
                     SSYAWSSPVCVYNKDGSGKVLYCNSTGDIRLLDGKTGKQEDVLSVSEGVIEASPAVYDN
                     YAVVGTRDCKIWGIRLQ"
     CDS             complement(8205..8615)
                     /locus_tag="ctg77_4"
                     /transl_table=11
                     /translation="MQERSEMQQRQGYQAVEKLRETLDEKYLWEVILLYAGESFKTYTG
                     LPFTYEVRKGRNGDYTRELWIDRRENSKSLALSSVLLALRNIKKVGAVVDRPKALGDIR
                     GVSYIYGMFYRFGLIDVPDTARQKMKFTGYIF"
     CDS             complement(8714..8917)
                     /locus_tag="ctg77_5"
                     /transl_table=11
                     /translation="MNDSMNPLGSHKDRHARIGEGEIGLEALVRVINHPATEGIPFILE
                     TPNDDEGWTHEIALLRNEYKQK"
ORIGIN
        1 aatcccctcc tgagtgttgg taagaggata actttcctgt acttctcttt tgctttcttt
       61 tcccgcagtt tttacaaatt cctccatcat tcggatagtg ggatgattct taatatctga
      121 agttttgatc acaatgtcaa aggctttgga gatcaggata ttcagcttaa tggcagtgat
      181 ggatgtcaga cctgcctcat aaatatctgt ggtaatccca aaatccgtat accccagaac
      241 ctctgcgata cagtcaaata atatctgctg aacctcattc tcaggcttaa tgatctccgc
      301 tgcttttttc tcaggcagag gaagagcctt tttatttacc ttctggttct ggttcagagg
      361 aattttgtca atctgcatgg taactgcagg taccatatag gcaggctttg tctctttaat
      421 aaaatcattc agggcattga tatcaacagt gctgtccgat accacatagg cagcaatata
      481 ttttccacca tttggatcat caaaggcaac tacagtggca tccctgatgc cctcatatct
      541 gcggatcact tcctcaacct cagaaagccc aatcctgaaa cctctgatct taacctggga
      601 atcctttctg ccaatgctct ggatatttcc atccggaaga aatcttgcca catcacctga
      661 atgatacatc acttcgtatc ccggtgtatc atcataaaga ttctttgtat agacctcggc
      721 agttttttcc ggcttgttaa gatatcctct ggaaacctgc cagccggtga tcatcagctc
      781 tccgcatgca ccgggaggaa gcatatgccc cagcttgtct gtaatataaa gcttcacatt
      841 gtcaagtgct tttccgatcg ggacatttgg ataatatttg tccacttcaa atacagtcgt
      901 aaaaatagtc gcctctgtag gtccataagc attgataaac ttataatctt ttggcggctc
      961 acatggaacc agtttctctc ctcctacaga aagatatctc aggctcttac aatccatctc
     1021 cagcgcaaac tgccttccca cctgagtagt cataaaggaa tgcgtgatgc cattttcctc
     1081 aaaatagcgc tgcagtccaa tgaaatccag acggatctcc tccggaataa tgtgaagctg
     1141 tgcaccgttt gtgatggcac cgtaaatatc catcatgcag gcatcaaaac caaaggaagc
     1201 atatgcagct accctggaat ccgaatctat gccataatac ctcttgaacc agtgacagaa
     1261 agcagtaata tttccatatt ccagcataca gccctttggc acacctgtgg aaccggaagt
     1321 atacaaaagg ataaacagat catgcagctg cggcttctta agcacaacat ccctatcctc
     1381 cagctgccag atctgatctg taaacagcac cggtccttta tatccgttta ccagaggaag
     1441 aagctctctg tcagcaatga gaagctttgc agaggaatcc tccatcatgt acatcaggcg
     1501 gtccctggga taggttggat ccagaggctg gtaagctgca cctgccttta tcacgcccat
     1561 cggtgcgatt gccatatatt cacagcgggg gatcagaatg gaaacaacat cttcactgcc
     1621 gattccctgg gatgcgatat attttccaag tctgtcactg atctcatcca gttctctgta
     1681 agtatatttt ttatccttaa ataccacagc cgtatggtca ggaatggtct gtaccagctc
     1741 ttcaaacata tcagcgatag tcttacttct gtcatattcg caggcagtat tattaaattc
     1801 cgcaattgtg tccgctccat tttgagaaag aacagaaact tccgaaatat atttcgcttt
     1861 cagcagtgaa tccatagctg cctcatagga ttccagcatt ccacgtacaa aggcttcact
     1921 gtacatgtca ctgcggtatt ctgcagtaag cacatattta tgatcgtatt ctcttacctg
     1981 gatcaacaga ggcatctttg acatatccgg agaaagatca tgacccctgg caacggtatc
     2041 accgattggg aaatcatccc caagctctgc ctgatatgca aataccagat cagaattaat
     2101 cccgtacttt gcacaaatat cagagaacgg aaaaatatca tttgccatgg aagacagaat
     2161 ctgctcagag agctctgtca tataggcctg tatggtgact ttcggatcac aggaacagta
     2221 aaccggcaga gtctttacaa gcatgcagac tgtattctcc agtctggaat catttcttcc
     2281 attataaata gttgcaaaaa gactctcctc ggaattggaa tatctgctca tgagaatacc
     2341 gaatacacct gtaaacagaa tgtttggagt aacccccagc ttctcgcagg cagaaagtac
     2401 cagagactct ctggtgtcca caggcatcga cagatatcct ctctcaggag tctttcctga
     2461 acagtcagga agaggcaggg attctgtctc aattccctcg aaaatactgt cataatattt
     2521 ctcggccttc ttatattttc cctctttcat ctgctgttct tcatcaaggg cagcatcaaa
     2581 gcctgtgtag gattctttct ccaatttctc acccagatag gcccgatcga tatcctcaaa
     2641 aataatatca taggaattac catctgccag gatatggtgg aaatctgtaa aaagatattt
     2701 cctgtcttct gtcacataaa tccccgcccg gaacagccgt cccttttcca gcttaaaggg
     2761 acgcaccagc tcatctttta tcttttcaaa ctgctcattt gtggtccgga ccacctctgg
     2821 tacaaaggct tcctcacaag gcttctgcac catctctccg ctgtcactta aataaacctt
     2881 tgtcagcaga tacggatgtg cagcgatcat ctgagaaatg gcatctgaca gcttctgaac
     2941 gtcaacagaa ctttccagtt caaacaggaa cggaatattg tataccgtac tctcaggatt
     3001 cttcatgcac tctgcaaaaa tacccttctg ggagccggta agagggtaaa cttctctctt
     3061 ttcataggtt ctgatcttcg gtgcaagcat cacatatttt tccagtttct ccaccgtatt
     3121 gttttcgtgg atatcactgg ttttcacagt cactccgaat tcctctgaga tcagaataca
     3181 aagcttcatg gcactgatag aagacagccc cgccctgtaa aaacttgtgt cagttccaaa
     3241 aaaatcattc tccacaacgt ctgcaacgat ttcaaaaatc ttcttctgca taggagtctg
     3301 gggttctttc agattctttg gctgtgcaac cggctttggc agtgctttct tatcaatttt
     3361 gccattctgt gtcacaggca tcttttccag ttggacaaaa acctcaggaa ccatataatg
     3421 agccagggac tctgatgcat aggcagaaag ctcctctgta ttgatctggc ggtcagccat
     3481 aaaatagcag cagaggaatt tgttatctac aggcagagta atgctggtaa tgattccctc
     3541 ataggaattg atcacttcct cgatctcacc aagctcaatc ctcagaccgc gaagcttgat
     3601 ctgattgtct attcttccga aaaattcaat ctcaccctca gggctgatcc ttgcaaggtc
     3661 accggtctta taagctctct ctccgttaag atcaatgaat acaacctctg ttttatccgg
     3721 cagattcata taacctctgc caacgcccag tcctgcgatc acaagctctc cggtctctcc
     3781 gtccggaagg atcttattct ctttatctac aatatatacc ttcacattac cgttaggcgt
     3841 accaatggta atgtttctgc tgtccgtaat taccttcatg gtacagctga tggtagtttc
     3901 cgtaggtcca taaccattca taatgtaagc atccgggttt actctgcgaa tcttgtcata
     3961 cagagccgga ggaaaagcct ctgcacctac atcaaacacc ttaatctgag aaactgcttt
     4021 ttcaagctgg ggcagatcga tcatattgga caggtaagta ggagttgtgg tcataatatc
     4081 cactttattt ctgacgatca gctcacccag cataagagga ttcagaatct cctcatcaga
     4141 ggcaatcacc gcagtcatcc cgttggtaag tggcagaaat tcctccagaa cagacacatc
     4201 aaaggtcatg gctgccatgg aaagagaaac cgatcccctg ctgacataac cataagtttc
     4261 cgcatttttc ggatccggat ttacaaaatt ggcaaggttg atatgttcga tcagcacacc
     4321 cttgggcttg cctgtggaac cggaagtata gatacaataa caaagatcat gctccccgat
     4381 ctttacctga ggattctctg tattctcatt ctccagaagt tcctcgatca gaagtactgt
     4441 acagggaagc ttcgcaaaca gttcccttcg ttcctctgcg atctcctttg ttgtgataat
     4501 aaaaggagct cctgaatcct caaaaatata ccggatcctg tcatcaggat aatccggtgt
     4561 ggcaactgca aatgcgcctc ctgccttcag gataccctgc cgcactgcat agaaatcaca
     4621 gcatctctca agaaccacac ctacgatggt ctcccgtctg acaccttttt ccacaagtgc
     4681 attggcaatc ctgttggccc gttcgttgag ctgtgcatag gtgaaactct ctttgccgga
     4741 gacaactgca catttctcag gatgaagctt cacctgttcc tcgaacaatt ctgttaccgg
     4801 ccgaaactca aaagcaaaat tgttcctttc attaatattt ttcattttca tgtacctcct
     4861 aaaaagatat tatggtatta ttcatatcaa tcgcacgaat ataatccatg gattttgata
     4921 ccttcttgac aagttcaatc ccatgtatat caaagtcttc actgtcatac tgatattcca
     4981 gagggttgaa attcacaccg ttatctctga tcctcagtct gcagagatca tcctccagac
     5041 agaggttaat gtcgatccag ttggaggttt ttcccccgaa tcgtataata tttacagtca
     5101 tttcctccgc acacactgcg gcaagatttg ccttgctttt agaagctccc tgttcctggc
     5161 agaactctat gatcctctta tgaaccgttt gtgcttcctc catggtactc ttaatggaaa
     5221 aatccagatt aatccccgga tttttgtcag gaacaatata aaagcttgta ttcttatgcc
     5281 tgatttttct gaaaatacag gctgcaactg cagttatgat ctcagttgca acaaatccca
     5341 ctgcaattcc gtcgataccg atcccgtcaa tctgtttcca tacaaggatt cccaccaggg
     5401 ttgcaggcag aactaccacc gcattctcca gaaatgtggc aaaacttgca atggctgtct
     5461 cctcaatgga ctcgtaatag ctgataataa acttattcca cagataaggt gccacacaca
     5521 aagcaaagat tcgcagcgcc tggaccatat ggctgcccag ttcgccaccg ccgcttccga
     5581 acatgacagt gatctcctcg gtaaacagca taataaggac aaagatcaca gccagcagga
     5641 tgtaactgta tttcagcatc tttttacaga gaacccggat tcccacgtaa tccttctctc
     5701 cgaaaaggat tcctgccaca ttggggatca caccgatgat tccgcctgta agcatctcga
     5761 cgatcagcag cacattgtca cagacagtaa atactgccat accttcctcg cccagctggt
     5821 tcatgataat ggtattcagt ccaagcgcct ttacaaaatt agctgccata aagatcagca
     5881 ttggcacgcc tgtgatgatt gcttcctttg tgattccaag ttcgcccggc tttagcagga
     5941 tcaggtggag gtttcgctta tcagagcgga tataaagcac aaaaattccc attgcaaaca
     6001 ggaaaccaag aacagttgat aaggatgcac ctgtaatccc cagaggagta tatctgagga
     6061 atatatagtc cagcacaaga ttgatcacat tggctgcgat aaggtaggct gatgccagct
     6121 ccggatgatt ctccactcca aggtaattga ccatcatcag tccaattccg atcaccggtg
     6181 cccccagcat acttacacgt atgtaatctc tggtataacc ggtcaggaca ccgtcacctg
     6241 ataccagaag tctggcaaca ggttctgctg caggaagggc acagattgaa aaaatgattc
     6301 ccaccacaag tgttactata aatgtggcag aaaacaattt cgatgcccct tctttgtctc
     6361 gtttgccaag catgtttccc actgctatgg aaccgccgat accaaggcag tatcctgtca
     6421 gctgaacgat cgtctccaca ggcaggctca gggtaactgc agacattgcc tccaccccga
     6481 tcaggttact tacaaatatc gtatctacga tatttcccag ctgaagcgcc agagacatca
     6541 taatccccgg aacaatatac ttgttcagct tcgcattcag cagtctgtta tttctctctt
     6601 ccatcgcttc ctctcctttg ttttcagttt tttcaaaata ttgtgccgta aaactgtaag
     6661 atatttaaat tttaccattt agtgcgataa atggcaagtt aataaagaat gggagaaagc
     6721 aaataaatat tgctatttac tgtaacctga ttccccatat tttacagtct ctggtgccta
     6781 caaccgcata gttatcgtag acagccgggg aagcctctat cacaccctcg ctgacagata
     6841 atacatcttc ctgtttacct gttttaccat caagaaggcg gatatcacct gtactgttgc
     6901 aataaagaac ctttcctgat ccgtctttgt tataaacgca caccggagaa gaccaggcat
     6961 atgaggaaga atcctcccat gctttagatc cgtcagattt tctcagacag gcaagaactc
     7021 cggatgcatt gtcagaggtc tttgccactg tcacatatat ataatcggca agactgttct
     7081 ttccacaggc aatcgtagac tgaactccac cggaaacacc gtcatcagta gtacattcat
     7141 aatctgtatg ccacacgatc tcaccggttt ctgcatcaat cttccagaca gggacagtgg
     7201 ctgtgtcata acttctccat ccaaggcgga aggaagtact tacatacaga tacagatgtc
     7261 ctttttcgat ttccagaaca ggcgttgaat tagaatcatc caatgtatcc tgaacccata
     7321 ccagctgaag agtgttcaga tccagacaca taagatttcc cccattatcg gtcataaata
     7381 tatagccttt atagattgcc gcactgtctt ccattccaag ccagaaagac tctgtactgc
     7441 ttcttgttcc atagtagcgc cattttacag ttctgcccgg atcaatggat aaagtcccac
     7501 tgttcagatc atattttgta ttcagcctga tcagatacag gattccgttc tctcccggat
     7561 agatcagggt atctgtctct gcatccacaa gtgctgatcc gtcaaaaaag ctcagacttc
     7621 ctctgagtga aaactcatca ttgtctccaa aagtatacat aacactacaa tccagcaagt
     7681 ttactacaaa tacctttgca gttccttcgt tgctgttata tccggcgcca acatacataa
     7741 tcggatatcc tctcggatta agggcacccg cacccttaaa agtatatccc agatataatg
     7801 gatcacgtgt cttttctccc gttctcaaat ccagaaaata cacataccca tccatacagg
     7861 cataaatcac ctcaaccagt tcatcatctg cctttgcttt ctctgtcata ttcatatgtg
     7921 ctttgacctc ttttggccat ttcatcataa gcggctgtcc tgtccagcca cttcctgtcc
     7981 agactgcact gcccgaagaa agagaacctg tatctgcaga ccacagtttg tccagcctga
     8041 aatcagtcat atctgcataa ccatgggaag gggtatcgcg aaaactgttt ccgcgaaatg
     8101 tgacgatccc atccacctca atattagtat agctgatcag attttccggt tttgtagaat
     8161 ccacacaatg aggctgaaaa ttaatctctt tagtctcttt cctcctaaaa aatatatcct
     8221 gtgaatttca tcttctgcct ggctgtatcc ggcacatcga tcagcccaaa gcggtagaac
     8281 attccataga tataactcac tccgcggatg tcgcccagag ctttgggtct gtcaaccaca
     8341 gctcccacct tctttatgtt tctcaatgcc agcagcactg aacttaacgc cagactctta
     8401 ctgttctccc tacggtcgat ccacaattcc cttgtgtagt ctccattccg accctttctt
     8461 acttcataag tgaacggaag ccctgtatag gttttgaaac tctcacctgc atagagtaaa
     8521 ataacctccc acagatactt ctcgtccagt gtttctctca gcttctctac tgcctgatat
     8581 ccttgtcttt gctgcatctc tgatctttcc tgcattcctt ccttttgatc tcactcctac
     8641 tctttcgatt tgcacttaca acttgtcagc acgccccaat ttatcttcct gattcgaaca
     8701 gatatattta tactcatttc tgtttatact catttctgag caacgcaatt tcatgagtcc
     8761 atccctcatc gtcatttggt gtctccagaa taaacggaat tccctctgtg gcaggatgat
     8821 tgatcacgcg gacaagtgcc tccagtccta tttcaccttc tccgattctg gcatggcggt
     8881 ccttatggct gccaagggga ttcatgctgt catttaaa
//
