LOCUS       c00030_gnlPro..        14290 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PPFIPPEA_30.
ACCESSION   c00030_gnlPro..
VERSION     c00030_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 23:10:07
            Original ID  :: gnl|Prokka|PPFIPPEA_30
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14290
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14290
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[8586:14194]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      8587..14194
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14290
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14290
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             401..931
                     /locus_tag="ctg30_1"
                     /transl_table=11
                     /translation="MNYNRLETSLIDVIKEEQAKLGYMKEKISLYYPLSSLNHFFGGET
                     DATGMMEILKDFPSYIEEKFGEVAVSHRGDRFCFTVSEKASEYVHNNMKENEFIKALIE
                     LVGRHGCTIEEIKELFHSYSDKIITEPMDNEEFDVMIRFDDGSDPYYYCFKDEGCHIIY
                     HRFLPEDYADFGF"
     CDS             1185..2603
                     /locus_tag="ctg30_2"
                     /transl_table=11
                     /translation="MRKTKIICTMGPSTDKGDVMEQLVREGMDVARFNFSHGPHDEQRG
                     RIQKLRELRKKYDRPVAALLDTKGPEIRLGCFKDGKVSLEEGQIFTFTNKDIEGTNECV
                     SITYKELYKDVQPGGHILVDDGLVDLEVQDISGKDIVCKVINAGVIGDKKGVNVPGANL
                     KMPFISKKDHDDLLFGIQEGFDFVAASFTRTANDIREVRKILKENGGEEIQIIAKIENQ
                     QGVDNIDEIIEAADGIMIARGDMGVEIPPEYVPVIQQKIIQKVYTAGKPVITATQMLDS
                     MISHPRPTRAEATDVANAIFQGTSATMLSGETAAGKYPVQALQMMSRIAEHMEQNIDYN
                     TIFKKTDRNENPDITNAIAHATCLTAIDLKASAILAVTKSGSTAHMMSKHRPGCLIGAC
                     TSSERVLRQLNLSWGVYPMLIKEEYSSEILCLRAIEAAQKHKLVKVGDTIVFAGGVPLG
                     IPGRTNLIRVCTVE"
     CDS             2772..3458
                     /locus_tag="ctg30_3"
                     /transl_table=11
                     /translation="MKTNEEEDSRHIFRGELALVIAVMINSLAVILMLYSGSGISAISS
                     VPYAFEKVFPVITLGTWTYIFQALLILSLMILRKKFVPAYLCSFLVGFAFSELLDVNEA
                     WINILPKTIPLRVLYFVISYLLICIGIALSNRCGLPIIPTDLFPRELSEIIKVKYSKIK
                     VSFDVICLMITACMTGLILGHINGLGIGTVMAAFTMGKVIGLIGDEMDKHFRFVNFTQH
                     CSLHVQ"
     CDS             3594..3791
                     /locus_tag="ctg30_4"
                     /transl_table=11
                     /translation="MQIMKRLLIKNKRKLWLWFLLLVFLFLACRAAYITGSKAEQTRNN
                     EVEERQADSRSIPNEMEILC"
     CDS             3785..4549
                     /locus_tag="ctg30_5"
                     /transl_table=11
                     /translation="MLNQFSRTELLLGKEAMNKLENSRVAVFGIGGVGGYVCEALVRSG
                     VGTFDLIDDDKVCLTNLNRQIIATRKTVGQYKTEVMRDRILDINPKADVRIHNCFYLPE
                     NAADFDFSEYDYVVDAVDTVTAKIELIMRAKEAGTPVISSMGAGNKLDASAFRVADIYK
                     TKVCPLAKVMRRELKKRGVKKLKVVYSEEQPIRPIEDMAISCRSHCICPPGATHKCTER
                     RDIPGSVAFVPSVVGLIIAGEVIKDLTAEYRR"
     CDS             4890..6074
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 78.4; E-value: 1.6e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg30_6"
                     /sec_met_domain="MFS_1 (E-value: 3.3e-25, bitscore: 78.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTFQGSYGISLQKIT
                     LLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHAMAAAGLILLTVLPECLGDPFVGLL
                     IAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRIFG
                     IANWKYMALVWALIPIANGIFFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCA
                     GASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQ
                     YSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALL
                     ALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMIMGIKMIGSLQKYD"
     CDS             complement(6487..7452)
                     /locus_tag="ctg30_7"
                     /transl_table=11
                     /translation="MSLLKEISITDLSNLRIGHASDYNAQTGVTVLYFPLGAKVGCDIS
                     GGGPASRETPLTSPVTADNPINAIVLSGGSAYGLAAADGVMNYLESQNIGYNTGAALVP
                     LVCQSCIYDLSYGDPKIRPTAKMGEEACRQAFAGTDTRTGNIGAGTGATVGKLYGMKQS
                     MKSGLGIAAVSVGNFQMAAIVVVNALGDIFSPQNGQKIAGLKTPDRSGFLDSVHELYRF
                     MTPHDQFTGNTTIGAVITNGAFSKAELNKIASMTRCAYARCINPVATMADGDSIYAASI
                     GDVSVDINMAGTLAAEVMAQAIQNAIHTSRIQDEEFLKYV"
     CDS             complement(7577..8212)
                     /locus_tag="ctg30_8"
                     /transl_table=11
                     /translation="MNTTTTTTTAATKRSSTLYMVELAMMIAIILLMSFTPLGYLRTPG
                     LSITLLTIPVAVGAIILGPKGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFIV
                     CIVARVLEGWITGLIFAALYKSPAKKFSYYVASLACPLLNTFFFMGFLCLFFYNTDYIQ
                     GIVSSLGVSNPVVFVAAFVGVQGLIEAGFCFVVGSIVSKALSVALKRA"
     CDS             complement(8587..8946)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_9"
                     /sec_met_domain="ALS_ss_C (E-value: 6.4e-23, bitscore:
                     70.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIK
                     VFNCSREDKAELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEAV
                     RGGSVGIESISMMER"
     CDS             complement(9148..9861)
                     /locus_tag="ctg30_10"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISDHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAIKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     APGGYRGDTRANAARILYLCQKYQLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLI
                     LNNQLPKLKVFLQTR"
     CDS             10624..11880
                     /locus_tag="ctg30_11"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGDPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKGKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSAETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERHRKLDAAMDEIRMKFGNDKITRASIMNSN
                     ARIGRKAKAQMKNEKTEEP"
     CDS             complement(11949..12458)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_12"
                     /sec_met_domain="ALS_ss_C (E-value: 5.6e-23, bitscore:
                     70.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(12476..14194)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_13"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.1e-49, bitscore:
                     155.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIRLAESYRA
                     KGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
ORIGIN
        1 cttacaaaga aactccagaa ggaaatatat gatgtgacac ttcgttacgg acgtaagaac
       61 tgggattaaa tacataatga aataattgga ataatgacag cgtttcggat ataaataata
      121 tttggaacgc tgttttttta accgaatcaa gcagttattt ggttaaaaaa gcaacgaagg
      181 ggatggtttt gtctgctttg tttcattcag ccagagtgat ttgtcagagg gagaaaaaaa
      241 ggacagtttt gcaaggtctt tatttttgta tgaaaaagaa aacattgaaa ttgttttgac
      301 aggcgtacaa ttgaaaaaga aatgcattga ttttcaggca atgtctgata aaatattaac
      361 cagaaaaagc aaaagaacag attttcagga gggaaaataa atgaactata acagattaga
      421 aaccagtctg atcgatgtga tcaaagagga acaggcgaag cttggatata tgaaagagaa
      481 gatcagcctt tattatccgc tcagttccct gaatcatttc tttggcggtg agacagatgc
      541 tacaggcatg atggagattt taaaagattt tccttcttat atagaagaga aatttggtga
      601 agtagcagta tcacacagag gagatcgttt ctgcttcact gtttcggaaa aagcttccga
      661 atatgtacat aataatatga aagagaatga atttatcaag gcattgatcg aactggttgg
      721 cagacatgga tgtacgatag aggaaattaa agaactgttc cattcttatt cagataaaat
      781 cattactgaa ccaatggata acgaggagtt tgatgtgatg atccgctttg atgatggatc
      841 agatccttat tattattgtt ttaaagatga aggatgccat atcatttacc acagatttct
      901 gccggaagac tatgcagatt ttggattctg ataagaatga gtgaaaaatt ttccaactgt
      961 cggatcagcc aaaatatatg tgatatttgc aacaaaagta tgttattttt ttgtcaaata
     1021 tcaacaaaaa taagtcgaaa ttctatattg acagatagtc tcaataatgg taatttttat
     1081 ttgatttaat atttttattt atagaaacag gtaaaatttt attacattat tttacaggaa
     1141 taaaatagat aaaattgagt tgacagtttg gagggaaaga ttaaatgaga aaaaccaaaa
     1201 ttatctgtac aatgggaccg tctactgata agggcgatgt tatggagcag cttgtgagag
     1261 agggaatgga cgtagcacgt ttcaacttct cacatggacc tcacgatgag cagagaggcc
     1321 gtattcagaa actgagagaa cttcgcaaga aatatgacag acctgttgca gcacttcttg
     1381 atacaaaggg accggagatc agacttggat gcttcaagga tggcaaggtt tctctggaag
     1441 aaggacagat atttacattt acaaataaag atattgaagg aactaatgag tgcgtaagca
     1501 ttacttataa agagctttat aaggatgtgc agccgggcgg acatattctg gttgatgatg
     1561 gacttgtaga cctggaggtt caggacatct caggaaagga cattgtctgc aaggttatta
     1621 atgcaggtgt gattggcgac aagaagggtg tcaatgttcc gggtgcaaac ctgaagatgc
     1681 cattcatcag taaaaaagac catgatgatc ttctcttcgg tatccaggaa ggatttgatt
     1741 tcgttgcagc atcttttaca cgtactgcaa acgatatccg cgaagtaaga aaaatcctga
     1801 aagaaaacgg cggtgaagag attcagatca ttgcaaagat tgagaaccag cagggcgttg
     1861 acaatatcga cgagattatt gaagcagcag atggcatcat gatcgccaga ggtgacatgg
     1921 gtgttgagat cccgccggaa tatgtacctg ttatccagca gaaaatcatc cagaaagttt
     1981 acacagcagg aaaaccggtt attacagcaa cacagatgct tgactccatg atctctcatc
     2041 cgagaccaac ccgtgcagag gctacagacg ttgccaatgc gatttttcag ggaacaagtg
     2101 caactatgct ttcaggagaa accgcagccg gtaaatatcc ggtacaggca cttcagatga
     2161 tgagccgtat tgcagaacat atggagcaga atattgatta caatacaatc tttaagaaaa
     2221 cagacagaaa tgagaatccg gatattacaa atgcaatcgc acatgcaacc tgtctgaccg
     2281 caatcgactt gaaggccagt gcaatccttg cagtgacaaa atccggaagt acagctcata
     2341 tgatgtccaa acacagacca ggatgtctga tcggtgcatg tacaagctct gagagagttc
     2401 ttcgccagct gaatctgtcc tggggtgttt acccgatgct gatcaaagaa gaatacagtt
     2461 ctgagatcct ttgcctgaga gcaatcgaag cagcacagaa gcataaactt gtaaaagttg
     2521 gcgacactat tgtatttgcc ggtggtgtac cgcttggaat tccgggaaga acaaacctga
     2581 tccgcgtctg cacggttgag taagtcagga aaatatcagt agttgaagtg ggaaacttgc
     2641 ctgattcgat aaaaaatagt attttcagaa aatataagat gtaaaagaca caggggtctg
     2701 ccgtcagaaa agtatgacag aaaatatttt ctgacagcag tcccttgctt gtgttagagg
     2761 agagaattgt tatgaaaaca aatgaggaag aagattcgag acatattttc agaggagagc
     2821 tggcattggt gatagcagtc atgatcaaca gtcttgctgt tattctgatg ctgtattctg
     2881 gttcaggaat atctgccata tccagtgttc cttatgcatt tgaaaaagta tttccggtaa
     2941 ttacactggg aacatggact tatatttttc aggcacttct gatcttaagt ctgatgatac
     3001 tgagaaaaaa atttgtacct gcttatctgt gcagttttct ggttggattt gcattcagtg
     3061 agcttttgga tgttaatgag gcatggatca atatcctgcc aaagacaatt ccactcagag
     3121 tgttatattt tgtgatcagt tatctgctga tctgtatagg gatcgcactt tctaacagat
     3181 gcggtctgcc gattattcct acagatctgt ttcctcgtga actgtcagag attataaagg
     3241 tgaaatattc taagatcaag gtttcttttg atgtgatctg tctgatgatt actgcctgta
     3301 tgacagggct gatcctgggg catatcaacg gactgggaat cggaacagtg atggcggcat
     3361 ttaccatggg aaaagtaatt ggattgattg gtgatgagat ggataagcac ttccggtttg
     3421 tgaatttcac tcagcactgt tcacttcatg tacagtaaca gagtttcttc attgcaggat
     3481 ttttctttct atgatatact tgacgcatta tagaagtaaa gatatcataa gaaatctgtg
     3541 atggaagtat gttgcaactc tggtatctga aaataatata ttaaggaata gtgatgcaga
     3601 ttatgaaacg gttgctcata aaaaacaaaa gaaagctctg gctttggttt ctgctccttg
     3661 tttttttgtt tctggcatgc agagctgctt acattacagg cagcaaagca gaacagacca
     3721 gaaataatga agtagaagaa aggcaggcag atagtcggtc aataccgaat gaaatggaga
     3781 tattatgttg aatcaatttt caagaacaga gcttcttctg ggaaaagaag caatgaataa
     3841 actggagaac tcccgcgtgg cagtgtttgg aatcggaggg gttggaggat atgtatgtga
     3901 agcattggtc agaagcggtg tggggacctt tgatctgatc gatgatgaca aagtatgcct
     3961 gacgaatctt aacagacaga ttattgccac caggaaaact gttggtcaat ataaaacaga
     4021 ggtgatgcgg gacaggatcc tggacattaa tccgaaagcg gatgtgagaa tccataactg
     4081 tttttatctt ccggagaatg ctgctgattt cgattttagt gagtatgatt atgtggtaga
     4141 tgctgtggac acagtgactg cgaagattga actgatcatg cgtgcaaagg aggcagggac
     4201 tcctgttatc agcagtatgg gtgccggaaa taagctggat gccagtgcgt ttcgggtggc
     4261 ggatatctat aagacgaagg tgtgtccgct ggcgaaggtt atgcgtagag agctgaagaa
     4321 gcgtggtgtg aagaaactga aggttgttta ttcagaggaa cagccgatca gaccaattga
     4381 agatatggcg atcagctgca ggtcgcattg tatttgtcct ccaggtgcta cgcataagtg
     4441 tacggagcgc agagatattc cggggagtgt ggcctttgtg ccgtctgtcg tcgggctgat
     4501 tattgcagga gaggttatta aagacctgac tgcggagtac agaagataag aagtgtttat
     4561 tttgagatgt gtatggtgtc agaaatggta tggtacacat ctttttttgc gggaaatatt
     4621 ttgaattgga ttgatggatt acctgttaga gtgtatagaa ttgttatatg agaaaaagtc
     4681 aaaataacat aaaaatttat aggattttca aaatataatg aaagaaaaaa gaaagaatct
     4741 gtgatacact gtcattattg attgatagaa ctgtgaaggt gcagaatttg gtgaatgaga
     4801 atgcctgaac gatatcagcg taataaattg ttactgctta ctccgttctc agtaactaat
     4861 aaatttcaga ttggaggata tcatattgaa tgaaaacaaa ttacaacaga acagtgcagg
     4921 cctgttttat cggatatgtg gtgcaggcta ttgtaaacaa ttttgttcct ctgctgtttc
     4981 tgacatttca gggcagttac gggatttcgc tgcagaagat cacacttctg gttactttta
     5041 atttcggaat ccagttgctg gtagatctgg catcgattgg atttgtggac agaataggtt
     5101 atcgtgcatc tatgatcctg gcacatgcaa tggcggctgc aggtctgatt ttgctcacag
     5161 tattgccgga gtgcctggga gatccgtttg tgggacttct cattgcagtt atgatctatg
     5221 ccatcggagg cggattgctg gaggtgctgg taagtcctgt ggtggaagcc tgccctacag
     5281 ataataagga aaaagcaatg agtctccttc attcctttta ctgttgggga catgtgggag
     5341 tggtacttct ttctacatta ttctttcgta ttttcgggat tgcaaactgg aaatatatgg
     5401 cgctggtgtg ggcattgatt cccattgcaa atggaatctt ttttaccaga gttcccattg
     5461 ctccactgct ggatgagggt gaaaaggggc tgactatggg agagcttttt aagaaaaaaa
     5521 tcttctgggt tctgatgtta atgatgctct gtgcaggagc cagtgagcag gcggtaagcc
     5581 agtgggcttc tactctggct gagaaaagct ttggaatcaa taaaactatc ggagatctgg
     5641 caggtcccat ggcgtttgca attcttatgg gaagttcaag ggcattttat gggaaatttg
     5701 gagataaaat caatctggaa cgctttatgc aatacagtgc agttctgtgc atggtttcct
     5761 atctgatgat cgcatttatc ccggtacctg cgttgggaat ccttggatgt gcggtttgcg
     5821 gtctgtctgt aggtattatg tggccgggaa ccttcagcat ggcggctgcc tcagtaaagc
     5881 gtggcggaac agccctgttt gccctccttg cccttgctgg agatgtggga tgctcatccg
     5941 gaccaaccta tgtggggatg atttcaggag cactgaatga taatctgaaa cttggaatct
     6001 ttgcggcact gattttccct gtgttgatga taatggggat taagatgatt ggaagtctgc
     6061 aaaaatatga ttgagatata ttgaaaagta tggaacgatt aatttttcat attgatgtaa
     6121 acagcgcatt tctttcctgg gagtcagcca gaagggtaag ccaggggctg ccggatctca
     6181 gggagattcc ctcctgtgtg ggaggagatc caaagaaacg gacagagtac acacgctgtt
     6241 cccggacgaa ataccggaga aaatgtggcc acttcctgtc cgtaacctgt tatttctggg
     6301 aaaagcctcc gagcagaagc ttctgaatca gggaatccgt actattggtg atctggcaag
     6361 ggaacgggaa gcaaatgtac agctctggct tggagaaaaa ccagagcaca gatgaaaaat
     6421 gaagacagac aggaagaata aaagcgcaga gatgatactt tttctctgcg cttttatagc
     6481 ggactgttat acatatttca gaaattcttc atcctggatc cgggaagtat ggatggcatt
     6541 ttggatagcc tgagccatga cttctgcggc gagagttcct gccatattga tatctacaga
     6601 aacatcgcca atgctggcag catagatgga atcgccgtca gccatagttg ctacaggatt
     6661 gatgcatctg gcataggcac agcgggtcat agaggcaatt ttattcagtt cagcctttga
     6721 aaatgcccca ttggtgatca cagccccgat ggtggtattg ccggtaaact ggtcatgagg
     6781 tgtcataaag cggtataatt cgtggacact atccagaaac ccgcttctgt caggcgtttt
     6841 cagccctgcg attttctgac cattttgtgg actgaagata tctcccagtg cattgacaac
     6901 gacaattgcg gccatttgga aatttcccac tgatacagcg gcaataccaa gacctgactt
     6961 catggattgt ttcataccgt aaagttttcc cacagttgca ccggtacctg caccgatatt
     7021 tccggttctg gtatctgttc ctgcaaatgc ctgacggcag gcttcttcgc ccatttttgc
     7081 agttggacgt attttaggat ctccgtaaga gaggtcatag atacaggact ggcatacaag
     7141 aggaaccagg gctgcaccgg tgttataacc gatattttgt gattccagat agttcatcac
     7201 accgtcagca gcagccagtc cataggcaga acctccggac aagacaatag cattgatggg
     7261 attgtcggca gtgacaggag aggtgagagg agtttccctg gaagcaggac cgccaccgct
     7321 gatatcacag ccaacctttg cacccagtgg gaagtaaaga acggttaccc cggtctgggc
     7381 attataatcg gaagcatgac cgatgcgtaa atttgaaaga tctgtaatag aaatctcttt
     7441 taataatgac ataaaaatct cctttgtatt aaccgaatca ggtagggttc ctgctttaaa
     7501 tgtgccggat aaaaaaatcc tgactacagt gacaatgtag tcagggttgt ttggtaaacg
     7561 gctgttcttt taaagattat gcacgtttca gtgccacaga aagtgccttg gaaacgatgc
     7621 ttcccactac aaagcagaag cccgcttcga tcagtccctg aacgcccaca aaagcagcaa
     7681 cgaagacaac aggattgctt actccaagac tggaaacaat accctgaatg taatctgtgt
     7741 tgtagaagaa gagacataaa aagcccatga agaagaaagt attcagtaac gggcatgcca
     7801 gtgaagcaac gtaataggaa aatttcttcg ccggtgattt atataatgct gcgaaaataa
     7861 gtcctgtgat ccatccttcc agcacacgtg ccacgataca cacaataaaa gtgccaaatg
     7921 gattaatgtt aaaaagtgcg gcagcgaaag ctgaacttcc tgtgacagcc atatagaagc
     7981 tggttgcacc gaaagcaagt ccgcatacag caccaccttt cggtccgagg atgatagctc
     8041 ctacagctac cgggatggtg agaagagtga tggataagcc gggagtacga aggtagccca
     8101 gcggggtaaa ggacatgagc agaataatgg caatcatcat agccagctct accatgtaaa
     8161 gagtgctgct tctttttgtg gcagctgttg tagtagttgt tgttgtgttc atatgaattc
     8221 tccttttggt ctgataaaac ggcgcaatgc gtcccctgct tttcagacag tttagagtat
     8281 ggggatcagg cgttatgaaa aatatacatc agaacaaaag atatgaaaca agaaatatct
     8341 tccggtaaaa gtttccggtg tgtagacgcc ttacaggtcg cctcacaaat ttaaccagac
     8401 tgtgaagtgg atgactttat ccaccagact gtcagatgtg gaaatcagat gcattttctt
     8461 tcgaataacg ctcccgtaaa caataacaca tttgattaaa aactgcaata ttttatagta
     8521 tgtttgaaaa taaatacagg atatagaggt gtttctatat cctgcaaaaa atattgatta
     8581 tgagatttag cgttccatca tgctgatgga ttcaattcca acgcttccac cgcggaccgc
     8641 ttcaattctg tggaattctt ccttgatcag tttaacaact gcatcattct tggtggctgt
     8701 ctggacaaat tccagaagca gactgtcttt gccatagtca atgacttttg ccttgaaggt
     8761 ttctgcaatc tgaaacagtt ctgctttatc ttccctggag cagttgaaaa ccttgatata
     8821 gagaatttct ttcattctga caaatacatc tgtgaagtcg attaccttga taacctcgat
     8881 catgcggttt aactgttttt tgatctgttc aaaggtttca tcatcgctga ctgttgcgat
     8941 agtcattcga gatactgtgg ggtcctcggt agttcctaca gtaagactga tctatcacga
     9001 gatatgtaaa tggttaagtg agttttgcta gttaaaatgt actaaaatgt catctttttt
     9061 gataagaaat tatagaaaat aaacaaaata acacaatgca aaaaacaatg cataaaataa
     9121 aagaatgtcc ctttgaggaa cattctttta acgtgtctga aggaaaactt ttaatttggg
     9181 aagctggttg ttaaggataa gagtttccgg aaacatgagc tggtgaacga attcttcggc
     9241 ataggtgaaa tctccaacat gttcttttcc gtggctgtcg ctggacaaaa taacaggaag
     9301 ctgatatttc tgacagagat acaggattct ggcggcattg gctcttgtgt ctccccgata
     9361 tcctccgggt gcgagggaag cttcgtttat ttcaaaaata acattttccc gtaaagctgc
     9421 tcttgccagc gtttcataat ctacagggaa atgtgtatcg tcgcagtggc cgagtatttt
     9481 tacagcagga tgttttattg cattgatgta agcttctgta ttctgagata cagagcctga
     9541 acggtagttc tgccgatgca tactgatgat agcgtaatcc aggttgttca gcagttcatc
     9601 tgacagatct gtatgtcctg cactgtccag gatgtttagt tcaactccgt aaagaatatc
     9661 tatgccgaat ctttttctgg gataaaaagg aaggcttctg aaataagaag aagttccgga
     9721 agccagagtt cccgggccgt ggtcagaaat cccaaggagt ttcagtcctt ttttgctggc
     9781 tgcttttgcc atgtcagaga tggtacaggt ggttccgtga ccgctggcga tagaatgtgt
     9841 gtggatgtca gaaagataca ttgtttgtct cctttccaga gcggtttcta tatatgataa
     9901 gagccttacg gaagatgcaa agctgctgtt tgatggtaca ttcgttatat tcaagtatga
     9961 cagatgagga tttaaatgtc aatgaggaaa caaaataaaa acaactgaaa tacaacaaaa
    10021 atcaaataaa aagcaacaca aataaacggc tgatacatgt taaattatgt tgacttcggg
    10081 aaaatgagaa ggtataatgg aactatatga aaacacgggg gcttattgct gatcaatgac
    10141 agcgatagca ctgtttgctt atgtgtagac agttacttca tgagaaagga gtaacatgga
    10201 aaaatttcaa acatcagaca ttcccggaat tctcttatga atggctggag gctgaactgg
    10261 atactggtat gattccacaa atatggacag cgaagaaatt gctcctaacc tttatgacta
    10321 atcgataagt atatatcgag aggaaatgaa tcctcagaat taagtaaaaa aagttaccgg
    10381 gaacaatgtg accggtagcg aaatacagac gccgcactgc cgtatggcaa gtgcggcgtt
    10441 gttgttcaaa actctgatag cagagtgaaa tcaaacaaat ataaatacag taacagctca
    10501 gacaagatga tgtaaataaa gacacttttt tggacaaacg aggttcttac cctggagagc
    10561 agatcagggt aaaatgaaat catcagatat gaagagcgca attcatatat tggaggaaga
    10621 acagtgaaaa gtacggaacg attaattttt catattgatg tcaacagtgc atttctttcc
    10681 tgggaatcag ccagaagggt gagccagggg ctgccggatc tcagagaaat tccttcctgt
    10741 gtaggaggag atccaaagaa acggacaggt atcgtggttg ccaaatctat ccctgcaaaa
    10801 aaatacggga tccagaccgg cgagccagta gccatggctc ttcggaaatg tcccaatctg
    10861 gtgatcgttc ccagtgattt tgaattatac gataaatgtt cccgggcatt taaagcaatc
    10921 tgtgcttcct ttgcacctgt gatggaatct ttttccattg atgaggtatt tctggatatg
    10981 acaggtactt ctctgatcta tcctgaccct gtagctgctg ctcatgagct gaaaggcaag
    11041 attcacagag agctgggatt tacagtaaat gtaggaattt ctaccaataa gcttttggca
    11101 aagatggcat cagattttca aaagccggac agagtacaca ctctgttccc ggatgaaatc
    11161 ccggagaaaa tgtggcctct tcctatccgt aatctgctgt ttctgggaaa agcttccgag
    11221 cagaagcttc tgaatcaggg aatccgtacc atcggtgatc tggcaagaga aagagcatcc
    11281 aatgtgcagt actggcttgg ggaaaaaacg ggacatcagc tatggcaata tgccagaggt
    11341 atcgatgatt cccctgtaaa agcagtgcct gatgaggcaa aaggtttcag cgcggaaact
    11401 acttttaacg atgatattac ttccatagag caggtgtttc ccatactttt ggagcagtgt
    11461 gatgttctgg caaccagaat gcgcagaaaa gataagaaat gcaactgtat ttccgtgact
    11521 ttccgtactt tggatttcag aaaccgttca caccagacaa agctggaaaa tgctacagat
    11581 cttacagatg aaatttatat aaatgctaca agacttttta aagaattctg gaaaggacag
    11641 ccgctacgtc tgattggtgt ggcactgaca ggccttacag atggcactta tgaacagatg
    11701 tctctgtttg aagatacaga aaataaagaa cgccacagaa agctggatgc agctatggat
    11761 gagatccgga tgaaatttgg aaatgataag atcacccgtg ccagtattat gaacagcaat
    11821 gcacggattg ggcgaaaagc gaaagcacag atgaaaaacg aaaagacgga agaaccgtaa
    11881 gtaaagagag gactgagcat taagaacaat gcgacaatcc tccctttata aaaatttcag
    11941 aaaaagtttt atcgttccat catactgata gattcgattc ctacacttcc tccacgtacc
    12001 acttcaattc tgtgaaattc ttccttgatc agtttcacta ctgcgtcatt cttggttgct
    12061 gtctggacaa attccaggag caggctgtct ttgccatagt caatgacctt tgccttgaaa
    12121 gtttcggcaa tctgaaacag ttcaacctta tcttctttgg aacagttaaa aaccttaata
    12181 tacagaatct ctttcatgcg gacaaatacg tctgtgaaat caataacctt aataacctcg
    12241 atcatacggt tcaactgttt tttgatctgc tcaaaagttt catcatcact gacagttgcg
    12301 atcgtcattc gagatactgt ggggtcctcg gtggttccta cagtaagact gtccagattg
    12361 tagctttttc cggagaaaag tccggagatt ttggacagaa cacctacctg gttctcaaca
    12421 tagagagaaa tccatctttt tttcattcct ttatccataa taattttcct cctgatcaac
    12481 agtccataat catatcttct agagttccgc ctggtttgat cataggataa accatttcct
    12541 cagggtcaat gatgaattca attactgtag gtgcctttgt gttctttttt gcttcctcga
    12601 aggctgctgc aatttcctct ttttttgtga cacggattcc ttttgccctg tagctctctg
    12661 caagtctgat gaaatccggt gtgtactgtg gatattccat gccttcagtg cggcgggaaa
    12721 gtgctcctgc gcgcagattg gtcatagcat agcgtttgcc gtagaaaagc ttctgccact
    12781 ggcgtaccat tccaagatac tcattgttaa agatacacag gataaccgga agctcctcca
    12841 gaactgcagt tgcaagctcc tgaatgttca tctgcacacc gccgtcaccg gagataacga
    12901 tgacaggtct gtcgggattt ccgattttgg ctccgatgcc gcctggaaga ccatagccca
    12961 ttgttcccag accaccggac atgatcatct gtttgccctc tgtgatttcc gcatactggg
    13021 agacaagcat ctgatgctgt cctacatctg ttacgataat actgttctca aattgttcgt
    13081 tgatctcttt caggatatcc atcggactta aaagatcatt tggacgcatt ttaagcggat
    13141 gctcttcttt ccagtttttg atcaggttaa gccacttgtc cgttgaacat tcctggacgt
    13201 attcgttcat tttggtgata gcctcttttg catcagcaac aatggggata tccacctgaa
    13261 tgtttcggga aatggatgct gtatcaatat caatgtggat aatctgggca tgtggtgcaa
    13321 attcatgaag ttttccggtg attctgtcat tgaatctggt tccgatggag aacagcacat
    13381 cgcagttgct gactgccata tttgctgcat aggcaccatg catgccaagg tttccgatat
    13441 agagcggatg gtctgtgggg atagagcctt ttcccattac ggttgtgaca accggtactt
    13501 ttgtcttttc cactacttcc cggaaaattt catgggcgcg ggagattact acaccgccgc
    13561 ctgccaggaa taagggacgt tttgctttat ttaaaagttt gatggcacgt ttgagctggc
    13621 cgatgtggac atctgtgttg ggcttgtatc cgcggatatt tacattttta ggatattcag
    13681 cgctgccgag ttctgccatt acgtcctttg gaaggtcgat aaggacaggt cccggacggc
    13741 cggtgcgggc aatgtagaag gcttctttga tgatacgtcc caggtcttca cgtctgcgga
    13801 cggtaacgcc gtatttggtg atgcttctgg tgattcctac gatgtctact tcctgaaatg
    13861 catcgttgcc gatgaggtgg cgggctacct ggccggtgaa gcatacaaga ggtacgctgt
    13921 catagttggc ggttgcaagt cctgttacaa ggttggttgc tccgggaccg ctggttacca
    13981 gacatacgcc gactttgccg gtggttctgg cgtaggcgtc ggcttcgtgg acaagggcct
    14041 gttcgtgacg ggggaggatg attttgacgt cgtcctgttt gtagagttcg tcactgatgt
    14101 cgatggtaca ggctccgggg tagccgaaga ggtattctac gccttcttct tttaaggctt
    14161 ttactaagag tttgttgccg gatatttgtt tcatatttgg taaacctcct ttgtgtatgt
    14221 gtataggacg ctcagaaatt tatttgtttg gtgtgcggtt tcggagccta gtagatctaa
    14281 gtgtctgaaa
//
