LOCUS       c00033_gnlPro..        16931 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LIOGACJA_33.
ACCESSION   c00033_gnlPro..
VERSION     c00033_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 18:18:01
            Original ID  :: gnl|Prokka|LIOGACJA_33
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16931
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..147
                     /locus_tag="ctg33_1"
                     /transl_table=11
                     /translation="KTNVFLVILFLTTIFFIPNKLQVKTSNFHPLKTGFFTVLHKQTYH
                     PYL"
     protocluster    1..16931
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3951:6931]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3952..6931
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16931
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16931
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(1001..1213)
                     /locus_tag="ctg33_2"
                     /transl_table=11
                     /translation="MTKVCNIELHECVFKIAHLFFFLRTKPRLSQQGNRIKIFQGCDLH
                     TKFLQILYHSITTKVVAINIQALDE"
     CDS             complement(1232..2782)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_3"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.6e-48, bitscore:
                     155.9, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDQLSGIFSGLVSQYVFDIQVAPDHESRQELIDLLGDVASCSDH
                     LSCSVADGEGLQFTIVKDGMPTGIRFRAVPNGHEFTSLLLAVLNCDGKGKNIPDESICA
                     RVRALNGPIKLTTYVSLTCTNCPDVVQALNVMATLNSRITHETVDGAINQKEVEAMKVQ
                     GVPSVFADGKLINVGRSDLGELLSKLEAQYGINEGGVDNSVEKPVKNYDVLIVGGGPAG
                     AASAIYSARKGLNVAVIAERIGGQVKETVGIENLISVPQTTGQQLANDLLTHINDYPVD
                     ILEHRRVDKVELDGSAKLLTTSTGERFSAPALIVATGASWRKLNVPGEADYIGKGVAFC
                     PHCDGPFYKGKHVAVVGGGNSGIEAAIDLAGICSKVTVLEFMDELKADQVLQEKAKSLP
                     NVEVFLHSQSLEVLGNGDKVTGLRVKDRKTDAERVIDLDGIFVQIGLAANSGVFRDVVE
                     TNKPGEIVIDAHCRTNVPGIYAAGDVSTVPYKQIIIAMGEGAKAALSAFEDRMRGLIG"
     CDS             complement(2802..3368)
                     /locus_tag="ctg33_4"
                     /transl_table=11
                     /translation="MEPIINSQVPEFKVQAFQNGSFKTVSSEDIKGKWAIFFFYPADFT
                     FVCPTELVDMADKYGKFQEMGVEVYSVSTDSHFVHKAWHDASETIRKIKYPMLADPTGA
                     LSRAFGVMIEEEGMAYRGTFLVNPEGKIKIAEIHDNGIGRNADELLRKVEAAQFVASHP
                     NEVCPAKWKKGEATLKPSIDLVGKI"
     CDS             complement(3952..4602)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 55.4;
                     E-value: 2.7e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_5"
                     /sec_met_domain="Radical_SAM (E-value: 1.8e-34, bitscore:
                     110.8, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQGCPLRCLYCHNPDTWEVKRETPYLLEPEALLAEVLRYKNFIAK
                     GGVTVTGGEPLLQPEFLKEFFRLCRENGIHTALDTSGYICSGKALEVLEQVDLVLLDIK
                     TIDAGLHPRLTAVKLDNTLRFLDELEKRGIPVWIRHVIVPGLTDDDEALSKLAEYISSY
                     NVVQKAELLPYHTMGAYKYEAQGLDYKLKGVEPLSAERLANAKAIFMKHGVTV"
     CDS             complement(4691..6931)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_6"
                     /sec_met_domain="Gly_radical (E-value: 2.9e-45, bitscore:
                     144.5, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 1.6e-281, bitscore:
                     926.2, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFENENWAQFKGETWKKEINVRDFIQNNYKPYNGDDTFLVPSSE
                     KTKKVWNKLTEMFKVEREKGVYDAETKLPQGIDTYGPGYIDKENEVIVGLQTDAPLKRG
                     IFPKGGIRMVENSLEAYGYHLDPMTKEIFTKYRKTHNEGVFSAYTDEMIAARRSAIITG
                     LPDAYGRGRIIGDYRRVPLYGTQILIEEKKRFQKRLDIQELTEEIIQSREEITEQIKAL
                     KAFERMCAGYGFDVTRPAKDAREAVQFLYLAYLAAVKDQDGAAMSLGRTSTFLDIYIEK
                     DICEGKLTEEEAQELIDQFIIKLRIVRFLRTPEYNDLFSGDPVWVTESLGGQGVDGRSL
                     VTKTSYRYLHTLYNLGPAPEPNLTVLWFNNAPDNWKNFCAKVSIDTSAIQYENDDLMRP
                     DYGDDYGIACCVSPMKIGKQMQYFGARANLAKCLLYAINGGRDEKSGVQVAPRFEPITS
                     EYLDYNEVMEKYEQMMRWLAKVYVNALKIIHYMHDKYAYEAFEMGLHDGDVERIRATGI
                     AGLSIVADSLAAIRDTKVKVIRDERGLAVDFEREGEYVPFGNNDDRTDSIAVDITEKFM
                     EYLRQHQTYRKATPTQSILTITSNVVYGKKTGTTPDGRPGGTPFAPGANPMNGRDTKGA
                     VAALASVAKLPFQHAHDGISYTFAVSPATLGKERDIQINNLVSLLDGYFTPDGGQHLNV
                     NVFDKDLLVDAMEHPEKYPQLTIRVSGYAVNFVKLTREQQLDVISRTINSSL"
     CDS             complement(7358..10087)
                     /locus_tag="ctg33_7"
                     /transl_table=11
                     /translation="MNKRFSTLLAAALVAGSFSSAFAQLEGRNVEWKDAQASRAYYLAG
                     VHFVSPTDYLQAFSLQGLVDGADITAANPVAAAQWTVETKKVGTVTHYAFKNIEGEQYL
                     AFEKKDGAYALAAKKEANDETKSFRWFTVAANGNLQAVLSDEKEPYFLGLKNDGTADWS
                     LALLQSSEHHTDGSTSVIKKKVALYEIYNDQITAEAFASKFCENFTIEFPETLDDMDVF
                     ENVSVEKIANDNLGFKLVDNKGTKDTKDDEYVVLANERVSNSELAANAIGYRYAKMTAK
                     AIKDKKIDDKNTVFYAEENETNIGDGKYALVQKVKVGDLDNKDVTFGKVTNDETTRQLA
                     SVEYDCHSTFMGVTVGKGTRVANTEVANERMLIVNVTAKVADKKNSSALGLKNDFTGAR
                     WYDKVSEADFDQPQGQWLVAAGSAANTIKLINVQKPGFVQDNIRLYEAEGENTYTVFAS
                     DLGLSGLETITLTKVEDYDKLNGYYSTLSDINQKFAFVTTGEYANEEAGSDLYLKAGVE
                     GDVVTVVPHAGSEWELIRNEKAQAVTASYKYYDGEKWVELNGKGNEEKGILPADTVRLA
                     YSYAINADELGLGTAWKMAKDDIEFFLKENGKGTYAIVYGATADEVKEYGVINGSEELV
                     AETTDFTNSTPFEIIDLDAAPSLAADSKHMTFEATNSIGFIASDENNNAVLAKETAALW
                     VDSVNAEGYATPKFFISYAGKMMTTAKKFREIVDKAYANDEISKKEYAELTADENLSYK
                     SVERIKFVDAERLSGEDTLVIADEKYTGKDIEDFKFKVTENEDGDYVLKANGNYVYVIN
                     GNLVYGTDAKEAEAFVIEVTSAPTANEGIATSEVKVIAGEGNVTIAGAAGKKVVICNIL
                     GQVVANTVVSSDNATIAAPAGVVVVAVEGEAAVKAIVK"
     CDS             10115..10204
                     /locus_tag="ctg33_8"
                     /transl_table=11
                     /translation="MYIEYRSYFLFNRFLPNSCILTRENVRFF"
     CDS             complement(10755..11207)
                     /locus_tag="ctg33_9"
                     /transl_table=11
                     /translation="VNLPVVCLEVGIELSGIVDTALFQYVQHAFLFVRRERAFAFSHAV
                     VSPASEPSHQLANGFLHQFVGHPVQHPDETERIGQFIGRAEISTSVGLLLLVFRADDVP
                     QFDFVADLLFCDSPQASSGFGAILFHAEQIGGGDVGGVDFFFHIFH"
     CDS             11790..13130
                     /locus_tag="ctg33_10"
                     /transl_table=11
                     /translation="MKRSTNLLAITLLTSCVTAFAQEQEETTTEKSAVEQSADIYAAGY
                     NKFRFGGYGEILANFMDYGINRFRGTDNGSKKDHRNSISIPRFVLAFDYKFNSQWVLGA
                     EIEFEAGGTGSAYEIENTENGEYEMEVEKGGEVALEQFHITRLIHPAFNVRAGHLIVPV
                     GLTNEHHEPINFFGTSRPEGETTILPSTWHENGIEVFGTFGRGYTRFNYQALVVAGLNA
                     NGFDRNTWVAGGKQGLFETDNFTSPGYVARLNYLGVPGLKIGGSFYYCHNTGANSDKPE
                     TYVKYGNIPLRIYTADLQYKNKYVTARANMIYGNLSKADDLSSVNNHQSGGSPYTQTTP
                     IAKRAVSYGGEVGFNLRAVCKDNMSVPVIYPFVRYEYYNPQEKGEGKHTMDLRNKVSMW
                     TAGANWYALPNLVVKADYTTRKIGGGKYNSENEFSLAIAYIGWFLSK"
     CDS             13167..14432
                     /locus_tag="ctg33_11"
                     /transl_table=11
                     /translation="MKKKNYFYLAALSLAMTFSMGACSDNNDPNPDGGGKDPVNLDYSS
                     ENASAWGNYMYNVAMLLNDDATMLYNSWVTDYVDEQGSHGPYATIFKDQTAGAYQSPLS
                     CIEEMIESGMWNIANEVGDAKIKDPYTKYTSGDKEGGLYAVESWYSWHSRDDYTNNIFS
                     IRNTYYGRIDDNDVSKVDGNLSAFNSYKDFDDEGDIAEHSLSKLIASTNPALDEEIKTL
                     IFASAKAIQAIPQPFRNNIDSEESVAAMNTCMELANLLLNEVKPYVNQTFGDPEYDDDL
                     DAIAEQFVDAVVLPTYKDLQEKNKLLLDAVNQFRQNPSNDNFEKACNLWITAREPWEKS
                     EAFLIGPVANLGLDPNMDSWPLDQNGIVQVLNSQNWDDLEWSGNFDEEDEAIGAAQSVR
                     GYHTLEYLLFKDGQPRTVDGAK"
     CDS             14654..16012
                     /locus_tag="ctg33_12"
                     /transl_table=11
                     /translation="MDMDKIDVPNGYALSAGTSTIFLNSSVAYDTNADWITGANSIRFN
                     NGDGLYDDVRTSNNGDGGGLGPVYAGYSCGSCHRNAGRTKPTLWENGGSGNYGFSSMLV
                     YISRRNGAFFRDYGRVLHDQAIYGVKPEGKLSVTYDKQTFSFPDGETYELCKPNYTITE
                     WYKDSIAPEDLFCTVRIPLRHVGMGQMMAIDRREIEALAAKSNYPEYGISGRCNYITEK
                     GVTGVGLSGNKAQHLDLTVELGFSSDMGVTNSRYPEEICEGQAQINQGSMMGLSYDQLD
                     ISTADMEDVDLYMQSLGVPARRNINDPQVILGEQKFYEAKCHLCHVTTLHTQAGGSTLL
                     NGTRLPWLGGQTIHPYSDFLLHDMGSEIMGVGLNDNYVSGLARGNEWRTTPLWGIGLQE
                     KVNGHTYFLHDGRARNLTEAIMWHGGEGEASKNLFKQMSKEEREAVIAFLNSL"
ORIGIN
        1 aaaacgaacg tttttttagt cattttgttt ctgactacta tcttttttat tcccaataag
       61 ttacaagtaa aaacaagtaa ctttcacccc ttgaaaacgg gcttttttac tgttcttcac
      121 aaacagacat atcatcctta tttataatca cttataaact tttactcaag taatactgca
      181 gtaacaaact gccattttga gaagaaggct gggaaaatgg agttaaaaac ggcctttagg
      241 tggcaaaaag aagaaaaatt atccataaaa taaaagaaag tgtgtcgtaa tgaacgatac
      301 gccattttgc agggcaactg cactaaaatt cagaaatcgt ataaaatata ccaaagaaaa
      361 aaacagggcc ttatcataca agtttttccc atttcctctg tcactgtatc actgatttct
      421 tttttatcga ttgatattca agctgtttcg ttagtgatat atgcccgttt tctctatcac
      481 tacggtatca ctaccctatc actggcaatt tagatgggaa acaggaatta cgcttataca
      541 catctgtaga ttagcgtatt ataaataaca caaacaataa acacccaatt tccatcccta
      601 taaatcactc gattatttta tgtaaaaacg gctataaaat aggtaaaacc gggtggtttt
      661 cattgttcgg cacggtactt ttgttgccgg acacccccat gttgccccct cttacacccg
      721 ggtgtaccgg ctctctacac ccggatgtta aggatggcaa catgggggtg tttacgaaat
      781 tatgtgcttg tctttgctaa aaaagagagg gcttttgtgg aatgaagaac cgtatttcgc
      841 caatttaaca cctattgcat tcgtttttac atttgtttat tcgattattt tatatgcttt
      901 ttcaaaggca aaagaaggca atatattggt ttccaatcat atgataaaaa cgtcctgtta
      961 gaggagtgat agaggcagtg atacaggatg ttttcctcta tcactcatct aacgcttgaa
     1021 tattaatagc tacaaccttc gtagtgatag agtgatagag gatttgtaga aacttcgtat
     1081 ggagatcaca accttggaaa attttgatgc ggttgccctg ttgtgaaagt cggggttttg
     1141 tgcgtaaaaa aaagaaaagg tgtgcaattt tgaacacaca ttcatgcagt tcaatattgc
     1201 acaccttcgt cattcacaac aaatacgaat attaaccgat taaacctctc atacggtctt
     1261 caaaagcaga cagagctgct ttcgctcctt ctcccattgc tatgattatc tgtttgtagg
     1321 gtacggtcga tacgtcgcca gccgcataga tgccgggaac attcgtccga caatgcgcat
     1381 cgattacaat ctcacccggt ttgttcgttt cgacaacatc gcggaaaacg ccactgttgg
     1441 ctgccaagcc gatttggaca aagattccgt ccaggtcgat cacccgctcc gcatccgtct
     1501 tacgatcttt tacacgaaga cctgtcacct tatcgccatt accgagcact tccaaagatt
     1561 gggaatgcaa gaaaacttcc acattcggca agctctttgc tttttcctgc aacacttggt
     1621 cggctttcag ttcgtccata aattccagaa ccgtcacttt cgaacaaatg ccagccaaat
     1681 ctatagctgc ttcgataccc gaatttccac cgccgacaac cgctacgtgc ttacctttat
     1741 agaacggacc gtcgcagtga gggcaaaaag cgacaccttt tccgatatag tccgcttcgc
     1801 ccggaacatt caacttgcgc cagcttgcac ctgtcgccac gataagggca ggagcagaaa
     1861 aacgttcacc ggtagaagtg gtcagaagtt ttgccgatcc atccagttcg actttatcca
     1921 cacggcgatg ctccagtata tcgaccggat agtcgttgat atgtgtcaga aggtcgttcg
     1981 ccaactgctg tccggtagtc tgaggaacgg aaatcaggtt ctcgatgccg accgtttctt
     2041 tgacctgtcc tccgatacgt tcggctatca ctgcgacatt caagccttta cgtgccgagt
     2101 agatagcaga agctgcaccg gcaggtccac ctcccactat taacacatca tagttcttaa
     2161 caggtttttc aacagagtta tcaacacccc cttcattaat tccgtattgg gcttcgagtt
     2221 tggaaagcaa ttctcccaaa tcactacgcc ccacattgat cagtttgcca tcggcaaaaa
     2281 cagaagggac tccctgtact ttcattgcct caacttcttt ttggttgata gcgccatcca
     2341 ccgtttcgtg ggtgatccgg ctattgagag tagccatgac attgagtgcc tgcactacat
     2401 ccggacaatt ggtgcaagta agagaaacat aagtcgtcag cttgatcgga ccattcaagg
     2461 ctctgacacg agcacagata ctttcgtccg gtatattttt accttttcca tcgcaattca
     2521 ggaccgctaa cagcaaagaa gtaaactcat gtccgttagg tactgcacga aaccggatac
     2581 cggtaggcat accgtctttt acaattgtaa actgaagtcc ttcgccatcc gcaacgctgc
     2641 atgacaaatg atccgagcat gatgccacat caccaagcag gtctattagc tcctgacggc
     2701 tttcgtgatc gggagcgact tgtatatcaa atacatattg ggataccagt ccggagaaaa
     2761 tacccgaaag ctggtctttc attgctgagt ctaacataac tttagatctt accaaccaag
     2821 tcgatactcg gcttcaaggt tgcttcgcct tttttccact ttgcaggaca aacttcgttc
     2881 gggtgagaag caacgaactg ggcagcttca actttacgaa gcaattcgtc tgcattacgg
     2941 ccgataccgt tatcgtggat ttcggcaatc ttgatctttc cctcgggatt taccaggaac
     3001 gtaccgcgat aagccatacc ctcttcttca atcatcacac cgaatgcacg gcttaaagcc
     3061 cctgtcgggt ctgccagcat cggatatttg atcttacgga tcgtttcgga agcatcatgc
     3121 catgctttgt gtacaaagtg cgagtctgta cttacggaat atacttcgac acccatttcc
     3181 tgaaatttgc cgtacttgtc agccatgtcg accaattcgg tcggacatac gaacgtaaag
     3241 tcggcaggat agaagaaaaa gatggcccat ttgcccttga tatcttcgct acttactgtc
     3301 ttgaaactac cattctgaaa agcttgaact ttgaattcgg gtacttgtga attgataatt
     3361 ggttccatga tttttactat ttaatttgtt actactattt ttgtttaccc tacaaaggta
     3421 aatcgtaaga tactgattga aagaattttt caaattgata atttttatct gccgatagac
     3481 ggatttctat ctgcaagcat acttatctac tatgacaata ggaagcaaag taatgttttc
     3541 cggaacaata aaaatatacc taattgtagg taaaatacct ttcgatcata ccatgtgatt
     3601 ctttaattgt taactttgga tgttaactta aaaatattcg aagatgagaa gagctagttt
     3661 gtataataca ttttcagcaa gtctattgct cgtttgcaac gcatgtcttt cttcatgtgt
     3721 ctcacaaata ccccttacaa aggaaaaacc ggtaaacaat tccacttatc aagtcgaata
     3781 tctgttcgaa cacgaagggt gtaaggtcta tcgtttcatg gatatgggac attacatcta
     3841 tttcaccaac tgcaagggag atgttaccag tattgaaagc gacagcgtcc gcacagtcaa
     3901 ccggatcagc cgtaaaccga tcatcatcaa agagcagaca ctcgattagg tttatacggt
     3961 taccccgtgt ttcataaaga tcgctttcgc attggccaga cgttctgctg aaagcggttc
     4021 cacacctttc agcttatagt ccaggccttg cgcctcatat ttgtaagctc ccattgtatg
     4081 ataaggcaga agttcggctt tctggaccac gttatatgaa ctgatatatt cggccagctt
     4141 gctcaaggct tcatcatcgt ccgtcaggcc gggcacgatc acgtggcgaa tccatacagg
     4201 gatgccgcgt ttctccagtt catcaagaaa gcgtaaagta ttatcgagtt ttacggccgt
     4261 caaacgggga tgaagaccgg cgtcgatcgt cttgatatct aacagaacca gatcgacctg
     4321 ttcgagcacc tccaatgctt taccggaaca gatatagccg gaagtgtcca acgccgtatg
     4381 aataccgttc tcacggcaaa ggcggaaaaa ctctttaagg aattcaggtt gtaacaaagg
     4441 ctcgccaccg gtcacggtaa caccaccttt agcgataaaa ttcttatagc gcagcacttc
     4501 ggcaagcaac gcttcaggtt ccagcagata aggcgtttca cgctttacct cccaggtatc
     4561 cggattgtgg caatacagac aacgaagcgg acatccctgc ataaaaacga caaagcgaat
     4621 tccgggaccg tcaacggtcc cgaaactctc taaagaatgt atacgcccca acatattaat
     4681 caatggacaa ttataaactg ctgttgatgg tgcgcgagat gacgtcaagc tgctgttcgc
     4741 gtgtcagctt cacgaagttg acggcatagc cagaaacacg gatcgtaagc tgcgggtatt
     4801 tctccgggtg ctccatcgca tcgaccaaca ggtccttatc gaacacgttc acattcagat
     4861 gctggccgcc gtcaggcgtg aaatagccat ccaacaggct caccagatta tttatctgaa
     4921 tatcgcgctc cttacccaat gtagccggtg aaacggcaaa tgtataggag ataccgtcat
     4981 gcgcatgctg gaaaggcagt ttggcaacag aagccaaagc ggcgacagcc cctttcgtgt
     5041 cgcgtccgtt catcgggttg gctcccggag cgaacggcgt accacccgga cggccgtcgg
     5101 gagtcgttcc ggttttcttt ccgtaaacca cgtttgatgt gatcgtcagg atagattgtg
     5161 tcggagttgc cttgcggtat gtctgatgct ggcgcagata ttccatgaac ttctcggtaa
     5221 tgtcgacagc aatactgtcc gtgcggtcgt cattgtttcc gaaaggtaca tattcgcctt
     5281 cgcgttcgaa gtcgacagcc aaaccacgtt cgtcacggat cactttcact ttcgtgtcac
     5341 ggatggcagc cagcgagtcg gcaacgatag aaaggccggc gataccggtt gcgcggatac
     5401 gttccacatc tccgtcatga agccccatct cgaatgcttc atacgcatat ttgtcgtgca
     5461 tgtagtgaat gatcttcaga gcattgacat aaacttttgc caaccagcgc atcatctgct
     5521 cgtatttctc catcacttcg ttgtaatcca gatactcgct ggtgatcggt tcgaaacggg
     5581 gagccacctg cacacccgat ttctcgtcac gtccgccatt gatcgcatac aacaagcact
     5641 ttgccaggtt ggcacgagct ccgaaatact gcatctgctt accgatcttc atcggagaca
     5701 cacagcaggc gataccgtaa tcgtcgccat agtccggacg catcagatcg tcgttctcgt
     5761 actggatggc agaggtatcg atcgatactt ttgcgcagaa gtttttccag ttatccggag
     5821 cattgttgaa ccaaagcacc gtcaggttgg gttcgggtgc cgggccgagg ttatacaagg
     5881 tatgcagata acggtaagat gtctttgtca ccagcgaacg gccgtcaaca ccttgtccgc
     5941 ccagcgattc agtcacccaa acagggtcgc cggagaacag gtcgttgtat tccggagtac
     6001 gcaggaaacg gacaatacgc agtttgataa taaactggtc gatcaattcc tgtgcctctt
     6061 cttccgtcag cttgccttcg caaatatctt tttcgatata gatatcgagg aaagtagaag
     6121 tacgtccgag agacatggct gctccatcct gatcctttac ggctgccagg taagccagat
     6181 acaagaactg cacggcttcg cgggcatcct ttgccggacg tgtcacgtcg aaaccataac
     6241 cggcacacat tctctcaaat gctttcagcg ctttgatctg ctccgttatc tcctcacgac
     6301 tctgaatgat ttcttctgtc agttcctgta tatcgagacg tttctggaaa cgtttctttt
     6361 cttcgatcag gatctgggtt ccgtacagag gtacacgacg gtaatcaccg atgatacgtc
     6421 cgcgtccgta ggcatcaggc aacccggtaa tgatggcgga acgacgtgcc gcaatcatct
     6481 cgtctgtata ggctgaaaaa acgccttcgt tgtgcgtctt tctgtatttg gtgaagattt
     6541 cttttgtcat cgggtccaga tgatagccat aggcttccag actgttttcg accatgcgga
     6601 taccgccttt cgggaagata ccgcgcttca acggggcgtc tgtctgcaag ccgacgatta
     6661 cttcgttttc cttatcgatg taaccgggtc cgtatgtgtc aatcccctgg ggaagcttcg
     6721 tttcggcatc atatactcct ttctcccttt caaccttaaa catctcggtt agtttgttcc
     6781 acactttctt cgttttctcc gaagagggta cgaggaacgt atcgtctccg ttataaggtt
     6841 tgtaattgtt ctggataaag tctcttacat tgatctcctt tttccaggtt tctcctttga
     6901 actgcgccca gttctcgttt tcaaacttca taagcttatc ttgtctattt cggtttaggc
     6961 acgcaaagat acgtcttttc cccctatctg aaaaggattg taaaggacga gggatgttaa
     7021 accggagaaa atacctacaa atagggataa gggaaataaa aacgaagccc cggcagtacg
     7081 aataccgccg gggcctgttt tttgtctgcc gtccggtctt cacagaggga aaagcagtag
     7141 aacttttaat ttcattactt tagtattatt aatattaaat ccaaccgctc gttcgcctgt
     7201 cgcagggtaa ttgaaaccgt agatcaagaa aacctcttac atacggtttc acgcaggttg
     7261 tctagaatta tttgattata aaatgtcatt gtgcctgtgt aagggtggtt cgctaaccac
     7321 ccttacgata gacagtattg ttttttagta tcaatcgtta cttaacgata gcttttacag
     7381 cagcttcgcc ttcaacagct acaactacta cacctgccgg agcagcgata gttgcgttgt
     7441 cagaagaaac gacagtgtta gctactacct gacctaagat gttgcagata acaactttct
     7501 taccggcagc gcctgcgatt gttacgttac cttcgccagc gatcactttc acttcagatg
     7561 ttgcgatgcc ttcgttggct gtaggagcag aagttacttc gattacaaat gcttcagctt
     7621 ccttagcatc tgtaccgtaa accaagttac cgttgattac atatacatag ttaccattag
     7681 ctttcagtac atagtcaccg tcttcgtttt cagtaacttt gaacttgaag tcttcgatat
     7741 ccttgccagt atacttttca tcggcgataa ccaaagtgtc ttcaccagac agacgttcag
     7801 cgtctacaaa tttgatacgt tctacactct tgtaggaaag attttcatca gcagtaagtt
     7861 ctgcatattc tttcttgctg atttcatcat tagcataagc cttatcaaca atttctctaa
     7921 acttcttagc agttgtcatc atcttgccag cgtaagaaat gaagaacttc ggagttgcat
     7981 aaccttcagc atttacagag tcaacccaca aagcagctgt ttctttagcc aatactgcgt
     8041 tgttattttc gtcagaagcg atgaagccaa tgctattagt agcttcgaat gtcatgtgct
     8101 tgctgtcagc agccaaagaa ggagcagcat ccaagtctat gatttcgaac ggagtagagt
     8161 tagtaaagtc agttgtttct gctactaatt cctcagaacc attgattaca ccgtattctt
     8221 ttacttcatc agcagtagcg ccatatacga tagcgtatgt acctttacca ttttctttca
     8281 agaagaactc gatgtcatcc ttagccatct tccaagctgt tcccaaacct aattcatcag
     8341 cattgattgc atatgaataa gccagacgaa ctgtatcagc cggcaggata cctttttctt
     8401 cattaccttt gccattcagt tcaacccatt tttcaccgtc ataatatttg tagctggcag
     8461 taacagcctg tgctttttcg ttacggatca attcccattc agaaccagca tgaggaacaa
     8521 cagttacaac atctccttct acaccagctt tcaaatacag atctgaaccg gcttcttcgt
     8581 tagcatattc acctgttgtt acaaaggcga acttctgatt gatgtcagac aatgtactgt
     8641 agtagccgtt cagcttgtca taatcttcaa ctttcgtcaa agtgattgtt tcaagaccag
     8701 acaaacctaa atcagaagca aatactgtgt aagtattttc accttctgct tcatatagac
     8761 ggatattgtc ttgtacaaaa cccggtttct gaacattgat caacttaatt gtgttagcag
     8821 ctgaacccgc agcaaccaac cactgcccct gtggctgatc gaagtcagct tcagaaactt
     8881 tatcatacca acgtgcgcca gtgaaatcat tcttcaaccc cagtgcagaa gaattcttct
     8941 tgtctgcaac tttggcagtt acatttacga tcaacattct ttcgttggca acttcagtat
     9001 tagcgacacg tgtacccttg cctactgtaa cccccatgaa agtagaatgg cagtcatatt
     9061 cgacagaagc caactgacga gttgtttcat catttgtcac tttaccgaaa gtcacatctt
     9121 tgttgtccag gtcaccaact tttactttct gaactaatgc atatttacca tctccgatgt
     9181 ttgtttcgtt ctcttcagca tagaatacag tgttcttgtc gtcaattttc ttgtctttaa
     9241 tcgctttagc agtcattttt gcatagcgat aaccgattgc gttggcagcc aactctgagt
     9301 tggaaacacg ttcgtttgct aaaactacat attcatcgtc ttttgtatct tttgtgcctt
     9361 tgttgtcaac caacttgaaa cccaaattat cattggcgat tttttctacg cttacatttt
     9421 caaacacatc catgtcatcc aatgtttccg ggaactcgat tgtgaagttt tcgcaaaact
     9481 tgctcgcaaa agcttctgct gtaatttggt cgttgtagat ttcgtagaga gctaccttct
     9541 tcttgataac ggaagtagat ccatccgtat gatgctcaga actttgtaat aaagccaatg
     9601 accaatctgc tgtgccatcg ttcttcagtc ctaaaaaata cggttctttt tcatcagaaa
     9661 gcacagcttg caaattgccg tttgctgcaa cagtaaacca acgaaacgac tttgtttcat
     9721 cgtttgcctc ttttttggca gctaaagcat aagctccatc tttcttttca aaagccagat
     9781 actgttctcc ttcaatattt ttgaaagcat aatgtgtaac agttccaacc tttttagttt
     9841 caacagtcca ttgtgcagca gcaacaggat ttgcagccgt aatatcagca ccatccacta
     9901 atccttgcaa agaaaaagcc tgcaagtaat ctgtcggact cacaaaatgc acccctgcca
     9961 aataataagc gcggcttgct tgtgcatcct tccattcaac attacgcccc tccaactgtg
    10021 cgaaagctga actaaaagaa ccggctacca aagcggcagc caaaagagta gaaaatctct
    10081 tgttcataat ctaaaatgtt taattaataa taatatgtat attgaatatc gttcttactt
    10141 cctgtttaac aggtttttac caaattcctg tattttgacg agagaaaacg tacgtttttt
    10201 ttagtcattt ttgaggggct ttctggaggg tttgtgttgg aaagctggtt tttcgtactt
    10261 gttaagctat ctgattgata agaaagaata tagaaaagga aaaataattg gaagaaagga
    10321 ttgcaggttc aaaaagtagt tgtatttttg tgcagtgaaa atggcgaaag aaaacgtacg
    10381 ttttttcgct atttttcttc ttatacccat atacttctta ttagcaatga cttacattga
    10441 aaaaagtgcc taaagccata taaaaaaaga gctgttttca accgctcgcc aaactttttt
    10501 acatcttcat caaaacaaag ataatcaatc acctataaga ttaactccct ttattcacat
    10561 tggaggggaa aaacggcaaa aacagcaggt ttcgtaattt catcttggaa aagctccccc
    10621 ttctgttaaa gatatacaaa atacggagta ttggttgctt agctcaataa cagcttcaag
    10681 acttgcaaaa ccttacatta ttatgtatct ttacatcaac gtccgtcaca gacggatcaa
    10741 acaactataa tacattaatg gaatatatga aagaaaaaat cgactcctcc gacatcccca
    10801 cctcctatct gctctgcatg aaacaagatt gccccaaagc cactacttgc ttgaggagaa
    10861 tcgcagaaca acagatcggc gacgaagtca aactgtggca cgtcatcagc cctaaatacc
    10921 aagagaagca aaccgaccga tgtgcttatt tccgccctgc cgataaactg acctatgcgc
    10981 tcggtttcat cgggatgctg gaccggatgc cctacaaact gatgcaggaa gccatttgca
    11041 agctgatgag acggttcgga cgcaggactt actaccgcgt gcgaaaaggc gaacgcccgc
    11101 tctcgccgga cgaacaaaaa agcatgttga acatactgaa acagtgcggt atcaacgatc
    11161 ccggaaagtt cgatgcctac ttcgaggcat acgactggta agttcacatg acgctacttg
    11221 cctacgtatt ggttgtgcca tacctatgta acgaccgttt cctcggcatg aaacggttgt
    11281 gccaagctta tgtaacaggc gtttcctact caggaaacag ttgtgccaag ccgatgtaat
    11341 tgttttggca cagccggagc agcaaacata cccttgcggg aacaagtcca agactcgacg
    11401 ccgaacagat tccggacaga agcgaatggg aaacggaaac ataaaaaaga agcctctctt
    11461 cacagagagg cttctttttt ataccgaaaa taaccaataa aaacttttcg atatagttaa
    11521 tcatcttata tgcttacata attgacaaaa ggttttgata tagcgattat actaatagtg
    11581 ttactttctt aatgacattg caaagatacg ggtacttccc acctcctaca atacctatat
    11641 gtgagtaaaa aaacgtcttt tactacctaa tcaaggtgat attcaggcgc aatacctaca
    11701 aatgggtaac atcggaacct ttttacctac taattgcgat tgcacaccgt tgacagcccc
    11761 tctaattttg ccaaaaatta aaaaacgcaa tgaaaaggtc aactaattta ttagcaatca
    11821 ctctactcac ctcttgtgta acggcatttg cacaggaaca agaagaaaca acgacagaaa
    11881 aatccgcagt ggaacaatcc gcagacattt atgcagccgg atataacaag ttccgcttcg
    11941 gcggatatgg ggagatcctc gcaaacttta tggactacgg catcaaccgt ttccggggta
    12001 cggacaacgg aagcaagaaa gaccatcgca attcgatctc cataccccgt tttgtcttgg
    12061 ccttcgatta caaattcaat tcccaatggg tattaggagc agaaatagaa tttgaggctg
    12121 gaggtacggg aagtgcctat gagatagaaa acacagaaaa cggagaatac gaaatggaag
    12181 ttgaaaaagg cggtgaagtt gctttggaac aattccacat cacacgtctt atccatccgg
    12241 ccttcaatgt ccgtgccggt catttgatcg tcccggtcgg tttgaccaac gagcatcacg
    12301 agccgatcaa cttcttcgga acttctcgtc cggaaggcga aacgaccatc cttccttcta
    12361 cctggcacga aaacggtatc gaagtgttcg gtacgttcgg ccgaggctac acacgtttca
    12421 actaccaggc tttggtcgtt gccggattga acgccaacgg gttcgaccgc aatacatggg
    12481 ttgccggcgg caagcaggga ctattcgaaa cagacaactt cacctcaccg ggctatgtgg
    12541 cccgcctgaa ctatttagga gtaccgggat tgaaaatagg cggttccttc tactattgcc
    12601 acaatacggg agccaattcc gacaaaccgg aaacatacgt caaatatgga aacatacctt
    12661 tgcgcatcta tacggctgac ctgcaataca aaaacaaata tgtcaccgca cgcgcaaaca
    12721 tgatatacgg caacctgagc aaagccgacg acctcagcag tgtcaacaac caccaaagcg
    12781 gcggttctcc ttatacacag acaaccccga tcgccaaacg tgcggtcagc tacggtggtg
    12841 aagtggggtt caacctgcgt gcggtttgta aagacaatat gagcgtaccc gtaatctatc
    12901 cgttcgtccg ctacgaatac tacaacccac aggaaaaagg cgaaggcaag cacacgatgg
    12961 atttacgcaa caaagtaagc atgtggacag ccggagccaa ttggtatgct ttacctaatc
    13021 ttgtcgtgaa agcagactat acaacacgca aaatcggagg cggcaaatat aacagcgaaa
    13081 acgaattcag cttggctatc gcctatatcg gctggttcct cagcaaataa aaacaatata
    13141 aacaaattaa taacttatca ataaaaatga aaaagaaaaa ttatttctat ctggcagcct
    13201 tatcgctcgc catgacattc tcgatgggag catgtagcga caacaacgac cccaatccgg
    13261 atggtggcgg aaaagatccg gtcaacctgg attacagttc tgaaaacgcc agtgcatggg
    13321 gtaactatat gtataacgtt gcaatgttgc tgaacgacga tgcaaccatg ctctacaatt
    13381 cttgggtaac cgactacgtc gatgagcagg gttcacacgg cccatatgcc acgattttca
    13441 aagaccagac tgccggagct taccaaagcc cgctctcgtg tatcgaggaa atgatcgaaa
    13501 gcggtatgtg gaacatcgcc aacgaagtag gtgacgccaa gatcaaggac ccgtatacca
    13561 aatataccag cggtgacaag gaaggcggtc tctatgccgt cgaatcatgg tatagctggc
    13621 attcgcgcga cgactatacg aacaatatct tctccatccg taacacatac tacggccgca
    13681 tcgacgacaa cgacgtgtcc aaagtagacg gaaacctgag tgcattcaac tcttacaaag
    13741 atttcgacga tgaaggagac atcgcagaac actcgctttc aaaactgatc gcttcaacca
    13801 acccggctct cgacgaagaa atcaaaacgc tgattttcgc ttctgcaaag gcgatccagg
    13861 ctattccgca accgttccgc aacaacatcg acagcgaaga gtccgttgcc gcaatgaaca
    13921 cttgcatgga actggccaac ctgttgttaa atgaagtaaa accgtatgta aaccaaacat
    13981 tcggcgatcc tgaatacgac gatgaccttg atgcaatagc cgaacagttt gtcgatgcgg
    14041 tcgttcttcc tacttataaa gacttgcagg aaaagaacaa gcttttgctg gatgcggtaa
    14101 accagttcag acaaaaccca agcaacgaca acttcgaaaa ggcctgcaat ttatggatca
    14161 cggcacgcga accgtgggaa aagagcgaag ctttccttat cggtccggtc gccaacttag
    14221 gtctggaccc caacatggac agctggcctt tggaccagaa cggtatcgta caggtattga
    14281 attcacaaaa ctgggatgac ctggaatgga gcggaaactt tgacgaagaa gatgaagcca
    14341 tcggagccgc acagagcgta cgtggttacc atacattgga atatctccta ttcaaagacg
    14401 ggcagccccg cactgtcgat ggagcaaaat aaacatgcct ctgagacata aaacttgata
    14461 atagatcatg acaaaccttg aaacagcaga caaatgcccg ctgtttcagg gtttcagagt
    14521 aattacacaa tgcgactcgc gttattcgga aataaattca gaaaaccaat aaaatgatat
    14581 gaagcaatct tacctgttaa catcctcgct attcctgctc tttgcatgcg cagcttgtga
    14641 agaggacgat aaaatggata tggataaaat agatgtcccg aacggatatg cgctgtcagc
    14701 agggacttca acgattttcc taaactcatc ggtcgcctac gatacgaacg ccgactggat
    14761 aacaggagcc aactcgatcc gtttcaacaa cggcgacggt ctctacgacg atgtacgcac
    14821 cagcaacaat ggcgacggag gcggtctcgg acctgtttat gccggctatt cctgcggcag
    14881 ttgccatcgc aacgcaggaa ggaccaaacc gacattgtgg gaaaatggcg gatcgggcaa
    14941 ctacggtttc tcttccatgc tggtctatat ctcccgccgc aacggtgctt tcttccgcga
    15001 ctacggacgt gtattgcacg accaagccat ctacggcgtc aaaccggaag gtaagttgtc
    15061 cgtcacatac gacaagcaga ctttttcctt ccccgacgga gagacttacg aactatgcaa
    15121 acccaattac acgataaccg aatggtataa agacagtatc gccccggaag atttgttctg
    15181 caccgtacgc atcccgttac gccacgtcgg tatgggacag atgatggcaa tcgaccgcag
    15241 ggaaatcgaa gcgctcgctg ccaaaagcaa ttatccggaa tatggtatca gcggacgttg
    15301 caactatatc accgagaagg gtgtcaccgg tgtcggcctt tcaggaaaca aggcacagca
    15361 tcttgacctg accgtcgaac tgggcttttc aagcgatatg ggcgtgacaa acagccgcta
    15421 tccggaagag atttgcgaag ggcaggctca gatcaaccaa ggcagcatga tgggactctc
    15481 gtacgaccag ctcgacatat cgaccgccga tatggaagat gtggaccttt acatgcaaag
    15541 cctcggcgta ccggcacggc gcaacataaa cgaccctcag gtcatcttag gagaacaaaa
    15601 gttttacgaa gcgaaatgcc atctctgcca cgtcactacg ctgcacacgc aagcgggcgg
    15661 ttccacactg ctcaacggca cacgtttgcc atggctcggc ggacagacca tacatcctta
    15721 ttctgatttc ctactgcatg acatggggtc ggagatcatg ggagtcgggt tgaacgacaa
    15781 ttatgtcagc ggcctggcac gaggaaacga atggcgtact acgccgcttt ggggtatcgg
    15841 gctgcaggag aaagtcaacg gtcataccta tttccttcat gacggacgcg cccgcaacct
    15901 gaccgaagcc atcatgtggc atggaggcga aggggaagcc tccaaaaatt tattcaaaca
    15961 aatgagcaag gaagagcgtg aggcagtgat cgcattcctc aactccttat aatttatcca
    16021 taagacaaac taaaatgaaa caactgataa tcacaattgc agcattatta ctattgccgt
    16081 tggccgtcat ggcccaatat gaggaagata cggaaaacgg tgtcgtatca ctaaacggca
    16141 aagaaggttt tacaatcgct accaagaagg gggatttcgt tttcaaacct tatatgttgg
    16201 tacagaccag tgctaacatc aactactacg acgatgaagg gctggacccg gcctacaatc
    16261 aggacaatat acacaacagc ggtttctcga tcccttatgc catcctcggt ttcacgggca
    16321 aggcattcga ccgggtgaca ttcaacctct ccatcaatgc tgccggaaac ggaggaaaca
    16381 tccttcaaca ggcttggttc gacgtagaga taaaaaagag ttttgccata cgtgttggca
    16441 agttcaagac tccgttctcg cacgcttacc tgactacgct gggcgagacg ttaatgccga
    16501 cactgccgac atcgctcacc tcatccgtta tcctgcctta ttctcttaat gccgtgacac
    16561 cgaacatcgg catgggattc gacctcggag tggaagtgca cggattggta aaggataagt
    16621 tcggctacga agttgggatt ttcaacggaa cgggaagctc cgtcaacgtg gcatccaaaa
    16681 cgttcagcga cgactggcat atcccgtcat tgttgtatgc cggccgcatc acgtacatgc
    16741 cgaaaggagt tatgccgtcc aaccagggca gcccgaaccg tttgaaggaa gataagatgc
    16801 tgttcggtct ttccacttca ttgaatgtgg agagcgaaag cgaaagtacg aacgatttcc
    16861 gggcaggagc agaattcgcc atgttgaaga atcgcctgta tctcggcgct gaaatctatt
    16921 atatgaatgt a
//
