LOCUS       c00015_gnlPro..        14824 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ANFDJBBE_15.
ACCESSION   c00015_gnlPro..
VERSION     c00015_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 18:02:23
            Original ID  :: gnl|Prokka|ANFDJBBE_15
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14824
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14824
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1596:4824]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1597..4824
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14824
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14824
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             390..1418
                     /locus_tag="ctg15_1"
                     /transl_table=11
                     /translation="MLDMNVVSKEFDLSVDDIYYTVRCISKDAKSFTSGYDSKGKPIGD
                     HQDCPEIYSIGAVKNGVEMHWTGDAPKFRVYIKENGSWKKIAETYDNHYVHKGAKSGSN
                     TYTVRGVSKDGKKFTTMFNPTGVTYRYKTSDKTRDAFINYMMNHTDEWMPSLGSNHNLS
                     GIMFLDFDFDGVPELVAQKSDSKEYGFHSVVYKFEDGKLKRVGNVNDGFSIYYNKTAKK
                     YEVHDLKISLNVDDGYYWSGNSIITYDGENLFANMYSSRGVVEESNNIYYRYFDGNDKN
                     ISRAKYNEINLKQFNNCVNAHMFTEFIAIGYGDTSVWGENTTAENKQSLLDAYNSFSYE
                     KY"
     CDS             complement(1597..2637)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_2"
                     /sec_met_domain="IlvN (E-value: 9.6e-84, bitscore: 269.8,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.2e-60, bitscore: 194.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLR
                     DSGCDVIVGLYKGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKIAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(2698..3189)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_3"
                     /sec_met_domain="ALS_ss_C (E-value: 9.4e-30, bitscore:
                     93.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQEPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRVNTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             complement(3202..4824)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.1e-43, bitscore:
                     137.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKIYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             complement(5125..7449)
                     /locus_tag="ctg15_5"
                     /transl_table=11
                     /translation="MRYKYQLDNLNCAHCAGKIEAKIAETNGFEDVNFNFATKLLNFKS
                     ERQNPVSEIQAICDSIEDGVTVVDKTPKTNLKKYTYTLDNLNCAHCAGKIEAKIAETDG
                     FEDVSFNFATKLLNFKSEKQNPVSEIQAICDSIEDGVTVVDKTPKNDITTKPEPEITKK
                     KINRDTIFLAISIVLAVVSEILHLTLDGVTAVHYVVLAACFVATLLSGYKVFIKGAKNI
                     LKLRIDETTLMSVAVIAAFCLGDFVEAAMVTILFSIGEIFEDRAVDASRRDIEKLANIR
                     PDTATIIVDGAEQIVPAESVEIGSIIEVKPYERVPLDGIIIKGKTTLDTSALTGESLPV
                     DAGEGSEVLSGAINGSNLITVKTTKHFGDSTATRILQLVEDAAAQKGNSEKLISKFASV
                     YTPVVVLIAVAIAVIPPLCGLGAFSEWLYRALVCLVASCPCAIVISVPLSYYSGIGAAS
                     EVGVLIKGGKYIEALAKADTFVFDKTGTLTSGKLSVNKVNTVGSYSADEVLALAAASEK
                     YSAHPIASAIREKANGLELPELSDYSESAGHGTSAVYNGKTIQCGGSKILSDEEKKIAN
                     KDDSVFVIYDGQLIGSLNVSDTVRPEAKEVISQLKALGVKNTVMLTGDRQQPAENVKNE
                     LGLSECHAELLPAQKLELFKGLKSKSKGACFVGDGINDAPVLSASDCGIAMGFGSEAAI
                     EASDAVLASGTLKQLPKAIKIARSVINTVKGNIIFALSIKALVIILAAFGLAQIWMSVI
                     ADTGVSVVCVLIAARLLKKKY"
     CDS             complement(7460..7777)
                     /locus_tag="ctg15_6"
                     /transl_table=11
                     /translation="MENKEKTTTPEMPDIDVLFELADLFKVFGDSTRLRIMYTISENEM
                     SVLNIAEALSMEQSTISHQLRVLRQNKLVRVRREGKQIYYSLDDDHVKRIIEMGLDHVL
                     E"
     CDS             8497..9789
                     /locus_tag="ctg15_7"
                     /transl_table=11
                     /translation="LEKFVVTGGKPLSGEVTISGAKNAAVAIIPAVILCDEPCQIENIP
                     NISDVSLISRILQQMGANVRRINRSSLYIDPTKIRTCNAVTDLVRGMRASYYLLGALLG
                     KYGRAKVALPGGCNFGVRPIDQHLKGFEALGAATQLVDGAIIEAECDNLVGTHVYLDVV
                     SVGATMNIMLAASKAKGQTIIENAAREPHIVDLANFLNSMGADVRGAGTDVIKIRGVEY
                     LHGVTYSIIPDQIEAGTYMCAAAATRGCITVKNITPKHLESISAKLREMGVKITEYDEA
                     LKVDASSAPLKRCNIKTMPHPGFPTDCQPQFAALLMSVPGTSIINENVWDNRYQYVSEL
                     IRMGAQISVEGRLAIIEGGTPLTAAPVKATDLRAGAAMIIAALEINGTTEISNIQFIER
                     GYEDVVEKFRGLGADIKKVYFTGDNEQELGA"
     CDS             9914..10702
                     /locus_tag="ctg15_8"
                     /transl_table=11
                     /translation="LARAVPLFSGSKGNSYYIGSATEGVLIDAGRSCKQIENAMLANGL
                     DMSSIGAVFITHEHTDHCSALRVLAKRYGFKVYSSLGTLNALRAGNKLDPNTDADVITD
                     EVVIGNMRVQRIDTPHDAAESCCYRVTAPDGKSALIATDMGVMLPDVRTAAEQSDFVVL
                     ESNHDINMLKNGIYPYPLKQRILSNRGHLSNEACAKELVNLVEKGTLRLMLGHLSEENN
                     TVPLAMSTSVDLLTSNGMKYKSDYSLDVAPSVSTTKAIIF"
     CDS             10724..11209
                     /locus_tag="ctg15_9"
                     /transl_table=11
                     /translation="MIKINIICIGKIKEKYFTDAIAEYAKRLTAFCKFNIIELSEERIK
                     SNIPNRSQIDEVIFSEGKRIMQKISPSDYVVAMCIEGKPMSSEELSTLIDNASVSGKST
                     VDFIIGGSYGLDESVKKRADVRLSMSRMTFPHQMARMILSEQIYRAFEISSNGKYHK"
     CDS             11224..12966
                     /locus_tag="ctg15_10"
                     /transl_table=11
                     /translation="MALDGIFLRHIKTEIEKEALGARVSQIYQPNREELVFGLRTFSGN
                     KKLLLSARANSPRVNFCSSTPENPAQPPMFCMLLRKRIGGGKLVGLRQNGCDRVLMLDF
                     ECVNELGDTVMITVVCEIMGMYSNIIIVDSNGVIIDSLKRVDLTMSSKRLVLPNIKYEL
                     PESQNKLNLLKCTALDVCTAVKNLDTEMPLNKALLRTIEGASPIVCREIEYKVMEGATN
                     RIEGVLFDRLAVEIERLKSICSDCSGKPVVVYREDGKPMDFCFMNVEQYGDFAKVESKE
                     SFSDLLDGFYEARDSRDRMRVKSQSLTKLLNNTLERLARKIAKQKSELERCADREHLRI
                     CGDLLQANIYRIERGAEYVDVENFYDENNAILRIKLNPAISPSANAQKYYKDYRKAKNA
                     EIMLKEQLEKGREELDYIDSVLDTVDRAENEKDIAQIREELTEQGYLKVQKGKKPRQTT
                     LPPLEFESSDGFKILVGRNNRQNDKLTLKTASKNDMWLHTKDIHGSHVIVVSDGKKISD
                     TAICEAAQLAAYHSKARNSSQVPVDYTLVRYVSKPNGSKPGMVIYVNNKTLYVKPSQFK
                     IKTE"
     CDS             12972..13472
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_11"
                     /sec_met_domain="Isochorismatase (E-value: 4.4e-31,
                     bitscore: 99.3, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTLIVIDMQNDFIDGSLGTAEAVKIVPNVRKKIEEYRSNGDEI
                     IFTRDTHGEDYLSTPEGKKLPVVHCVKNTHGWQIADGLDVPDAIHIDKPSFGYTHWDKF
                     CFEKIELVGLCTDICVVSNALILKALFPNAEISVDSACCAGVTPETHNSALATMKMCQV
                     DVV"
     CDS             complement(13635..14177)
                     /locus_tag="ctg15_12"
                     /transl_table=11
                     /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIYTATDGEVI
                     FKKYSPVGELAEFASQYADVLAKISSMPTIITDRDHVIAAAGVSKREFLERRVTAVLEG
                     YMENRKTYSATQQTLGDIQPIEGIEHYASVIYPIIAAGDVSGAVVMLTGEQTKIPTNAE
                     IKLAQTAAAFLGKQMEE"
ORIGIN
        1 agcttgaaaa tgtaaacggc ggtgtgaaaa tctcttgggg caaagtaagc ggtgcgacta
       61 aatacagagt ttactacaaa ggcagtaagg gttggacaaa aatggttgat acaacttcaa
      121 cctcatatat cgacaaggat gtttcatccg gcagaaatta cacttatact gtaagatgta
      181 ttacatcaga cgcaaagaaa tttacaagcg gttataaccc gacaggcaag tcggtaaagt
      241 atgtagccac accgaaaatt tcaaaacttg aggtcacata tgacggagta aagctgacat
      301 ggaacaaggt tgcaggtgca gaaaaatacc gtgtgtacta caaggacaga aacggttgga
      361 caaagcttgg cgacacaacg ggtacaacaa tgcttgatat gaatgttgtt tcaaaggaat
      421 ttgatttaag cgttgatgat atttattaca cggttcgttg tatcagcaag gatgccaaga
      481 gttttacaag cggctacgat tcaaagggta agcccattgg cgatcatcag gattgtcccg
      541 aaatttacag cattggtgca gtaaaaaacg gtgttgaaat gcattggacg ggagatgcgc
      601 caaagttccg tgtttatatt aaagaaaacg gttcttggaa gaagatagca gaaacttatg
      661 acaaccatta tgttcacaag ggtgcaaagt ccggcagtaa cacttatacg gtaagaggtg
      721 tttcaaaaga cggtaaaaag tttactacga tgtttaaccc aaccggtgta acatacagat
      781 ataagacatc cgataaaaca agggacgctt ttatcaatta tatgatgaat catactgatg
      841 aatggatgcc aagtttggga agtaatcaca atttgtcagg tattatgttt ttggatttcg
      901 actttgacgg agttccggaa cttgttgcac aaaagtctga ttccaaagag tatggtttcc
      961 attccgttgt ttacaaattt gaagacggta agttaaaaag agtgggaaat gttaacgacg
     1021 gtttttcgat atactataat aaaactgcca aaaagtatga ggttcacgac ctaaagatat
     1081 ctttaaatgt agatgacggt tactattggt cgggtaattc aataatcaca tacgacggag
     1141 agaatctttt tgcaaatatg tattcgtcaa gaggcgtagt cgaagaatca aataatattt
     1201 attatagata ttttgacggt aatgacaaaa atatttcacg ggcaaaatat aacgaaatta
     1261 accttaaaca gtttaataat tgcgtgaatg cacatatgtt taccgaattt attgcaatag
     1321 gttatggtga taccagcgta tggggtgaga atacaacagc cgagaataag cagtctttgc
     1381 ttgacgctta taattctttc tcctatgaga agtattgatt atttaaaaat tgataagttt
     1441 taactgcaaa agggttcagc cgtaaaaagc tgaacccttt tattgcacaa caaaaaaacg
     1501 gttcagccaa attgactgaa ccgttaattc atactatgta atgctcgggt gacagaagtt
     1561 tgaatatatc aaactaactt cacgaactaa aaaacattag ttgttgatga gcttatcttc
     1621 gtcagaccag ctgtagagct ttctaacttc cttaccgaat acttcggcag gagcttcggc
     1681 agcgatcttt ctcatagcct tgaagtgaac ctgtgaaccg gcatcgctca tgtcaaggag
     1741 gaagtcctta gcaaatgtac cgtcctgaat gtcagaaaga acctttctca tagccttctt
     1801 agtatcctct gtgatgatct ttggacctgt gatgtagtca ccgtactcag ctgtgttaga
     1861 gattgaatat ctcatgcctg caaaacctga ctgatagata aggtcaacga tgagcttcat
     1921 ctcatggata cactcaaagt aagcgtttct tgggtcgtaa ccggcatcgc aaagtgtttc
     1981 aaaacctgcc tgcataagtg cgcaaacacc gccgcaaaga acagcctgct caccgaagag
     2041 gtctgtttct gtttctgttc tgaatgttgt ttcaagaacg ccggctcttg caccgccgat
     2101 accgagtgca tatgcaagtg cgagatcctt agcctgacct gtagcatcct gctcaacagc
     2161 aacgaggcaa ggtacaccct taccaacctg atactctgaa cgaactgtgt gacccggtcc
     2221 cttaggagct accattgtaa catcaacatc ctttggaggc ttgatgcaac cgaagtgaat
     2281 gttaaagccg tgagcgaaca taagcatatt gcctgcttcg aggtttggct cgatgtcgtt
     2341 cttgtaaaga gctgcctgct tttcatcgtt gataagaatc ataatgatgt cagcctgctt
     2401 tgcagcctct gccgatgtat ataccttaaa gccctgtgcc tcagcctttg cccagctctt
     2461 gctgcctttg taaagaccga cgattacatc gcaacctgaa tccctgaggt tgagagcgtg
     2521 tgcatgaccc tggctgccgt aaccgataat agcaattttc ttacccttga gaaggtcaag
     2581 gttgcaatct gactgatagt agattggtgc tgtcatgttt tttgtgtagt ctttcatatt
     2641 aaagtcctcc ttaccgcaaa cgcggcatat aaattaaaat atatgctaac tgtaagatta
     2701 aacggaaacc gaagctgtgc ctctgtcaat ggcaacagta cctgttctta caatctcacg
     2761 gataccataa ggcttgagta agtcaacaag cgtgttgacg cggcttgcac attcgcagta
     2821 ctcaacggta actgacgaag gggatacatc aacgattttc gcctgcataa tttcaaccgt
     2881 tttgacaatt tcggctcttt ttgaggcggc gcagtgaacc ttgattaaaa caagctcacg
     2941 gctgataaat tcgccctcgt taagcctttt taccttgatg acgggaatga gcttgtttag
     3001 ctgcttttca agctgttcaa caatgtactc gtcaccgttt gcaacgattg tgattcggga
     3061 aaccgacggt tcctgagtaa cacctactgc aagtgagtcg atgttaaaac ctcggcgaga
     3121 gaaaagtccc gaaatctttg aaagaacgcc cgcctgattt tcaacaagta ttgataatgt
     3181 atactgcatt ttatcacctc attaaattga cggagtgtcg gggtgaacat cgcaaacaag
     3241 aatgaacggc ttttccgaat caacaatacc cttgatgatg ttttcggctt ccttgtttga
     3301 atgagcctct gcatggtcaa tgccgtaagc atcggcaatc ttcaagaagt cgggatcacc
     3361 gttgagaatt gttgcggagt gtctgccgcc gtagtgtttg tcctgaagtt cacgaaccat
     3421 tccgagtcgt gcgtttttca taatgatgat tttaattccg agctgattgc ctgcaatagt
     3481 cgcaagctca ttaagcccca tctgaaaact gccgtcaccg cagattacaa taacatcacg
     3541 gtcgggtctt gcaaactttg caccgattgc agcgggaatt gagtaaccca ttgtacccat
     3601 accgcctgtt gtgagaaatc tgccctcacg aatacggaag ttgtttgcac accagatttg
     3661 attttgtcct acatcggcaa caagaattgc ctttgagcgg aacattgcgc tgagatgacc
     3721 gacaagtgtt ctcggctcaa caaagccgtc aaatacggga ggctcacggt aaaggtcttt
     3781 tttccagttc tttacggttt cgctccacat tgttgtaacc ttgtaatcgc cgatgctgtc
     3841 aagcagcata ttgatgacat ttttcatatc gcctacaatc ggaatttctg ttttaacatt
     3901 cttaccgatt tcagcagggt caatgtcaat gtgaattacc tttgtgtttt cactcatctg
     3961 gtcgggagcc gcaacagctc tgtcaccgag tcttgcaccg catacgatta caaggtcggc
     4021 ttcgtgaaga gcacggttgg caacagcctt gccgtgagtg ccgagcattc cgagataaag
     4081 ctcatgctcg ctgggcataa caccgatgcc catcatagtt gaaataacgg ggatacccgt
     4141 agtttctgca aatttttgaa gtttaagctt gatacccgaa ctcagcacgc cgccgcctga
     4201 tacgataaca ggacgcttgc ttgcgttgat ggcctcaaca gcctttttaa cctgaattgc
     4261 gtgtccctta gtgttcggct tgtaaccgat aatgtttacg ctttcgggat attcaaaact
     4321 ttcaatttca ttttcctgaa tatcaacggg aatgtcgata agtacaggac cgggtctgcc
     4381 ggttgaggca atatggaacg cctctttgaa aactctcgga aggtcttctg ttttgctgac
     4441 gagataactg tgctttacaa acggttcaca agctcccgtg atgtcagctt cctgaaagac
     4501 atctctgccg agaaggtcgg aacgaacctg acctgtaatg gcaacaatcg gaatagagtc
     4561 cgtataggcg gttgcaatgc ctgtgatgag gttggttgca ccgggaccgg aagttgccac
     4621 gcaaacaccg ggacgattac tgcatcttgc atagccgctt gccgcatgag cagcgttctg
     4681 ttcctgacga acaagaatgt gggtaatgct cgaatcgtaa attttatcgt aaaatgggca
     4741 gatagccgca cctggataac caaagactat atcaacgccc tcggcttcca aacattttac
     4801 cataatttca gcaccgctga tcattatgtt ttgtccctcc tatccttttt actgtgagca
     4861 aaaggtgttt tgtaacatta aatatacctt tttactttac cgctaattat acaataaata
     4921 ccttaaaaag taaagagcag tattgaccat aaattaaatt ttttgcagga ttttaaatta
     4981 ttctgtcatc gcctgaaaaa gatataataa atgattaaca acaaaagcaa aatgctgacc
     5041 ataaaagtat ctgtataaga gtaataacaa gaaaattccc gaacagtttt acctgctcgg
     5101 gaacagtaat gattgttgag aaaatcaata tttctttttg aggagtcttg cggctatgag
     5161 gacgcagacc acgctgacgc ctgtgtcggc gataacagac atccagattt gtgcaagacc
     5221 gaatgcggca aggataatta caagagcctt gattgagagg gcgaagatga tgttgccctt
     5281 gacagtgttg ataacacttc ttgcaatttt aattgccttt ggaagctgtt tgagtgtgcc
     5341 tgatgcgaga actgcgtctg acgcttcaat agctgcctca ctgccaaatc ccattgcaat
     5401 accgcagtcg cttgccgaaa gaacaggggc atcattgata ccgtcaccca caaagcaagc
     5461 acccttggat tttgatttca agcccttgaa aagttcaagc ttttgagcag ggagaagttc
     5521 tgcgtgacat tcggaaagtc cgagttcgtt tttaacattt tcggcaggct gttgtctgtc
     5581 gcctgtgagc attaccgtgt tcttgacacc gagcgcttta agctgtgaga taacctcttt
     5641 tgcctcaggt cttactgtgt cgctgacatt gagcgaaccg ataagctgac cgtcataaat
     5701 tacgaaaaca gaatcgtctt tatttgcaat cttcttctcc tcgtccgaaa gaatctttga
     5761 accgccgcac tgaatagttt tgccgttata aactgcgctt gttccgtgac cggcactttc
     5821 gctgtagtcg gaaagctcgg gaagttcaag accgtttgcc ttttctctga ttgcggaggc
     5881 aatcggatga gcggaatatt tttcgcttgc agcggcaaga gcaagaactt cgtcagcact
     5941 gtatgaaccg acagtattaa ccttgtttac gctgagcttg ccgcttgtga gcgtgcctgt
     6001 tttatcgaat acgaatgtgt ctgcttttgc aagagcctca atatattttc cgcccttgat
     6061 gagtacaccg acttcggatg ccgcgccgat acccgaatag taggagagag gtacggaaat
     6121 aacaatagca cacggacatg acgctacaag acaaacaagc gcacggtata gccactcgct
     6181 gaatgctccg agtccgcaaa gcggagggat tactgcgatt gcaactgcaa tgagtacaac
     6241 aaccggtgtg taaacagagg caaattttga aataagcttt tcgctgttgc ccttttgagc
     6301 ggcggcatct tcaacaagct gaagaatcct tgttgcggta ctgtcgccga aatgttttgt
     6361 ggttttgaca gtaataaggt tactgccgtt gattgcgccg ctgagtacct cactgccctc
     6421 gcctgcatca acaggaaggc tttcgcctgt gagagccgat gtgtcgagag ttgttttacc
     6481 tttaataata atgccgtcaa gcggaactct ttcgtatggc ttgacttcaa tgatacttcc
     6541 gatttcaacg ctttcggcag gaacaatctg ttccgcaccg tcaacaataa ttgttgctgt
     6601 atcgggacga atgtttgcaa gcttttcaat gtcacggcgg gatgcgtcaa ctgctcgatc
     6661 ctcaaaaatt tcaccgatag aaaagaggat tgttaccatt gccgcctcaa caaaatctcc
     6721 aagacagaat gccgcaatta ccgcaacaga cataagcgtt gtttcgtcaa ttctcagctt
     6781 tagaatgttt tttgcaccct tgataaatac cttgtaaccc gaaagaagtg ttgcaacaaa
     6841 acacgctgcg agtacaacat aatgaacagc cgtaacaccg tcaagtgtaa ggtggagaat
     6901 ttcggacact acagcaagta caattgaaat tgcaaggaag attgtgtcac ggttgatttt
     6961 cttttttgtg atttcgggtt ctggctttgt tgtgatatca tttttcggag ttttgtcaac
     7021 aacagttaca ccgtcctcaa tgctgtcgca gattgcctga atttcggaaa caggattctg
     7081 cttttcgctt ttgaagttga gaagttttgt cgcaaaattg aagcttacat cctcaaagcc
     7141 gtctgtttct gcaattttag cctcaatttt gcccgcacaa tgagcacaat tgagattgtc
     7201 taaagtgtag gtgtattttt tgagattggt tttcggagtt ttgtcaacaa cagttacacc
     7261 gtcctcaatg ctgtcgcaga ttgcctgaat ttcggaaaca ggattctgcc tttcgctttt
     7321 gaagttgaga agttttgtcg caaaattgaa gttcacatcc tcaaagccgt ttgtttctgc
     7381 aattttagcc tcaatcttgc ctgcacaatg agcgcaattg agattgtcaa gctgatattt
     7441 atacctcata tgttccccct tattcaagaa catggtcaag tcccatttcg atgattcgtt
     7501 tcacatggtc atcgtcaagg ctgtaataaa tctgttttcc ttcacggcga acacgcacca
     7561 gcttgttctg ccttaacaca cgcagttggt gggaaattgt gctttgctcc atgctgagag
     7621 cttcagcaat gttgagcacc gacatttcat tttccgaaat ggtgtacata atgcgaagtc
     7681 gggttgaatc accgaaaacc ttaaaaaggt ctgcaagctc aaacagcaca tcaatgtcgg
     7741 gcatttcggg agtggttgtt ttttctttgt tttccatagg cgtccccttt aattttctct
     7801 caggttaaaa gttatacttg aacatatgaa gatatgctca tatgttaatt ataatatagc
     7861 attcccattt aaaaaagtca atagacacac acgaaaaagt gtaataattt tcaagttttt
     7921 ttaccctaat atttcgcttg tttattgtgt tcgtttggag agtatatata atatagtata
     7981 ggaagagaag cttaaaataa aagggagaaa aggaagaatt aaaggtgcaa agttattccg
     8041 aagcggcaga atgatatttt tctgtattca atttgaattg taaaatgctc agactcctga
     8101 tgataacacg aaaataacac ttgtttcaat ttgtaacaat cttacaaaaa aagccgttga
     8161 gttattactt ctttttaagg aaaatcaatt caaaaaatga cgcttggtta taataaaaac
     8221 aaaaacagca agaaatcaat aaattgagta caacctgccc aaaaatagat tacagtttta
     8281 ttattccgtt gactttacta cagttttgta gtatcatttt ctgtaagaga attgataggt
     8341 tacatctgcg taatcgagca ggtttatttt taataaaatg taacaaatta gttcctgctg
     8401 cgaattttaa attcgtgtta tttttgagtt ttacttattt gatatatatt tcagatattt
     8461 ttttaatatc ttttgcacat aattggggtg taacaattgg agaagtttgt agttaccggc
     8521 ggaaagccat tatcaggtga agtgacaatc agcggtgcga aaaatgcagc cgttgcaatt
     8581 attccggcag ttattctttg tgatgaaccc tgccagattg aaaatattcc taacatcagc
     8641 gatgtatcgc tcatcagcag gattcttcag cagatgggtg ctaatgtaag gcgaatcaac
     8701 cgttcgtctt tatatattga tcctacaaaa atccgcacat gcaatgcggt tacagacctt
     8761 gtaagaggta tgagagcgtc atactatctt cttggcgcac ttttgggcaa gtacggcagg
     8821 gctaaggtgg ctcttccggg cggctgtaac tttggcgtgc gtccgattga ccagcatctc
     8881 aagggctttg aggctctcgg tgcggcaact cagcttgttg acggtgcgat tatagaggca
     8941 gaatgcgaca accttgtcgg tacacatgtg taccttgatg ttgtgtccgt tggtgcaaca
     9001 atgaacatta tgcttgccgc atcaaaggca aagggtcaga ctattattga aaatgccgca
     9061 agagaaccgc atattgttga ccttgcgaac tttcttaatt caatgggtgc ggatgtcaga
     9121 ggtgcaggta ctgatgttat caaaatccgt ggcgttgagt atcttcacgg cgttacctat
     9181 tcgattattc ccgaccagat tgaggcagga acatatatgt gtgccgccgc cgcaacaaga
     9241 ggatgtatta cggtaaagaa cattacaccg aagcaccttg aatcaatcag cgcaaagctg
     9301 cgtgaaatgg gtgttaagat tacggaatat gatgaggctc tcaaggttga cgcgtcatct
     9361 gctccgctaa agcgctgtaa catcaagact atgcctcatc ccggctttcc gacagactgt
     9421 cagccgcagt ttgccgcatt gcttatgagc gttcccggaa caagtatcat caacgagaat
     9481 gtctgggata accgctatca gtatgtcagc gagcttatca gaatgggcgc gcagatttcc
     9541 gttgagggca gacttgcaat cattgagggc ggaactccgc tcactgcggc tcccgttaag
     9601 gcaaccgacc ttcgtgcagg tgcggctatg attattgccg ctcttgaaat taacggcaca
     9661 accgagattt cgaacataca gtttattgaa cgcggttatg aggatgttgt tgaaaagttc
     9721 agaggacttg gtgcagacat taaaaaggtg tattttacag gagacaacga gcaggagctc
     9781 ggtgcctgat taaaacttaa ttagaaatca aagccgtttt ctttgtgaga acggcttttt
     9841 tgtgagataa aatttacaaa tcataaaatt tgtgttatca tatttggcag actaatgata
     9901 aggattgatt gttttggcaa gagcagtacc gctgttcagc ggaagtaagg gcaacagtta
     9961 ttacataggt tcggcaaccg agggcgtttt gattgacgca ggccgttcat gtaagcagat
    10021 tgaaaacgct atgcttgcaa acggacttga tatgagcagt atcggggcag tttttataac
    10081 tcacgaacac acagaccatt gcagtgcctt gcgtgtgctt gcaaagcgtt acggctttaa
    10141 ggtgtattca agtcttggta cgctcaatgc tttgagggca ggtaataagc ttgatccaaa
    10201 cacggatgca gatgttataa ctgacgaggt tgtaatcggc aatatgcgtg ttcagcgaat
    10261 tgacacaccc cacgatgcgg cggaaagctg ctgttatcgt gttactgctc ccgacggaaa
    10321 atccgcactt atagcaaccg atatgggtgt tatgctgccc gatgtcagaa ctgccgcaga
    10381 gcagagcgac tttgttgtgc ttgagtcaaa tcacgatatc aatatgctca aaaacggaat
    10441 ttatccttat ccgctaaagc agagaatcct ttcaaacagg ggacaccttt caaatgaggc
    10501 gtgcgcaaag gagcttgtca accttgttga aaagggaaca ttaagactta tgctcggtca
    10561 cctcagcgaa gaaaataaca ctgttccgct tgcaatgtca acatccgttg acctgctcac
    10621 atcaaacgga atgaagtaca aaagcgatta ttcgcttgat gttgctccga gtgtaagcac
    10681 aacaaaagcc atcatctttt aaccttaaac aaacaagaga aatatgatta aaattaacat
    10741 aatctgcatc ggaaaaatca aggaaaaata ttttaccgac gcaattgcag agtatgcaaa
    10801 acgcttgacc gcattttgta aattcaatat tattgagctt tcggaagaac gcattaagag
    10861 caacataccg aataggtcgc agattgatga ggttattttc tctgagggaa aacgaatcat
    10921 gcaaaaaatt tcgccttcgg attatgttgt tgcaatgtgt attgagggaa agcctatgtc
    10981 gagcgaggag ctttcaactt tgattgacaa tgcgtccgta agcggaaaaa gcaccgttga
    11041 tttcataatc ggcggcagct acgggcttga tgaatcggtt aaaaaacggg cggatgtccg
    11101 tctttcaatg agcagaatga cctttcctca ccaaatggca agaatgattt taagcgaaca
    11161 gatttaccgt gcgtttgaga tttcatcaaa cggtaaatat cacaaataat ttacggagtt
    11221 actatggcgc ttgacggaat ttttttaaga catattaaaa ctgaaataga aaaagaggct
    11281 ctcggtgcaa gggtgtcgca gatttatcag ccgaacagag aggagcttgt gttcggtctg
    11341 agaacatttt ccggcaacaa aaagctgttg ctttctgcac gagcaaattc accgagagtg
    11401 aacttttgtt cctcaacacc cgaaaatcct gcacaacctc cgatgttctg tatgcttttg
    11461 cgaaaaagaa tcggcggcgg aaagcttgtg ggacttcgcc agaacggttg cgaccgtgtt
    11521 cttatgctcg atttcgagtg cgtgaacgaa ctcggcgata ctgtgatgat aactgttgta
    11581 tgcgaaatta tgggtatgta cagcaacata attattgttg attcaaacgg cgtcatcatc
    11641 gattcactca agcgtgtaga tcttacaatg agcagtaaaa gacttgtact gccgaatata
    11701 aaatacgaac ttcccgaatc gcagaacaag ctgaatctgc ttaaatgtac tgcacttgat
    11761 gtgtgtacgg cggtaaaaaa tcttgacacg gaaatgccgc ttaacaaggc actgttaagg
    11821 acaattgagg gtgcttctcc gattgtatgc cgtgagattg aatacaaggt tatggagggc
    11881 gcaaccaaca gaattgaggg tgtgcttttt gaccgactcg cggttgaaat cgaaaggctg
    11941 aaaagcattt gcagcgattg ttcgggcaag cctgttgtgg tttatcgtga ggacggcaag
    12001 cctatggact tctgctttat gaatgttgag cagtacggcg attttgcaaa ggttgagagt
    12061 aaggaaagct tctccgattt gcttgacgga ttctatgagg ctcgtgacag ccgtgacaga
    12121 atgagggtga aatcacaaag ccttacaaag cttttgaaca acacccttga aaggcttgca
    12181 cgaaagattg caaagcagaa gagtgagctt gaacgctgtg cagaccgtga gcatcttcgc
    12241 atatgcggtg accttttaca ggcaaatatc tatcgcattg agcgtggtgc ggagtatgtt
    12301 gatgttgaaa acttttacga tgagaacaac gcaattttac gcataaagct taatccggca
    12361 atctcacctt cggcaaatgc tcagaagtat tacaaggatt accgcaaggc taaaaatgcc
    12421 gaaattatgc tcaaagaaca gcttgaaaag ggcagagaag agcttgatta tatagactcc
    12481 gttcttgata cggttgaccg tgcggagaat gaaaaagaca ttgcacaaat tcgtgaggaa
    12541 cttaccgagc agggctatct caaggttcaa aaaggcaaaa agccccgtca gacaactttg
    12601 ccgccgctcg aatttgaatc aagtgacggc tttaaaatcc ttgtcggaag aaacaaccgt
    12661 cagaacgata agctgacttt aaaaacagcg tcaaagaacg atatgtggct gcacacaaag
    12721 gacattcacg gttcgcatgt aattgttgtt tcggacggca aaaagatttc cgacacggca
    12781 atctgtgagg cggcacagct tgcggcgtat cacagcaagg cgagaaacag cagtcaggtt
    12841 cccgttgact acacactcgt tcgttatgta tcaaagccaa acggttcaaa acccggtatg
    12901 gtgatttatg tcaataacaa gacgctgtat gttaagccgt cacagttcaa aataaaaacg
    12961 gagtgatttg tatgaagaaa actttgattg taatagatat gcagaacgat tttattgacg
    13021 gcagtcttgg cactgccgag gctgtgaaaa ttgtgcctaa tgtacgcaaa aagattgaag
    13081 aataccgttc aaacggtgat gaaattattt ttacaaggga tactcacggt gaagattacc
    13141 taagcactcc cgagggcaaa aaactgcccg ttgtgcattg tgtaaaaaat actcacggct
    13201 ggcagattgc agacggactt gatgttcctg atgcaattca tattgacaag ccgtcattcg
    13261 gctatactca ttgggataaa ttctgctttg aaaaaatcga gcttgtcgga ctttgcaccg
    13321 atatctgcgt tgtgtcaaat gcgttgattc taaaggcact tttcccgaac gctgaaatca
    13381 gcgttgattc ggcttgctgt gccggcgtaa cccccgaaac ccataattcc gccctcgcaa
    13441 caatgaaaat gtgccaggtt gatgtggtgt gataatggtt tgaaaattca aactttataa
    13501 aaaacagtag tggcaaaccg tgttctctgc tacaagtaaa tgcataatta tacaaatacg
    13561 gtcgggaaaa ttcggtgtat tgttttacac ctttcttctc gaccgcattt tttattatta
    13621 cctattttta aaaatcattc ttccatttgc ttgccgagga atgcggcggc ggtttgtgca
    13681 agtttgattt cggcatttgt cgggattttg gtctgttcgc ctgtgagcat aactaccgca
    13741 cccgaaacat ctccggcggc gataatcgga tagattaccg atgcataatg ttcaatgccc
    13801 tcaatcggct gaatatcgcc gagcgtctgc tgtgttgccg aataagtttt gcggttttcc
    13861 atatatccct caagcacagc tgttaccctg cgctcaagaa attcacgctt tgaaactcct
    13921 gcggcggcga ttacatggtc acggtctgtt atgattgtcg gcattgagct gatttttgca
    13981 agcacatctg cgtattgtga cgcaaactcc gcaagctctc cgacaggcga atatttttta
    14041 aaaataacct cgccgtccgt tgcggtataa atttcgagcg gatctccctc acgaatacga
    14101 agcgtccgcc tgatttcttt cggtataacc actctgccga gatcgtcgat tcttctgacg
    14161 attcctgttg ctttcatatt taaaactccc ttcggacagt tctgtccctt gtctgataca
    14221 tattcagcaa attatttgca gtaatattgt ttgattcata cagtttttta taccgaaatt
    14281 ttctttggtg acatattttt acagcatata aaaaatataa ctttatcacg atttagttaa
    14341 tcgtaaccac ctaaattgca aaataatctt gacttagcaa aaacagtggt ttataattta
    14401 gttaatcgta aataactaaa tcgtagatga gtaatttgca aacggtcaga ggtgagaatt
    14461 ttgtttatag gcagaaagaa tgagctttta cagcttaaca gattgtataa cagcggaaaa
    14521 tttgaatttg ccgtcatata cggtcgccgc cgtgtaggaa aaacggctat cataaacgag
    14581 tttgtcaagg acaaaaacgc aatttgtttc acaggagttg aaacaaatgc aaagcaaaat
    14641 cttgaaaatt tgagcgagtg tattcttgaa ttttcaacag ggatgaaaac ggatactgct
    14701 ttttcaaact ttcagtcggc acttgaatat gtttttaaat tgtcagagaa caaaagaatc
    14761 gtcctttgcc ttgacgaata tccatatgta gcaagagcgt caagaagtct tgcttcaaca
    14821 ctgc
//
