LOCUS       c00044_gnlPro..        22423 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GMCGOJKJ_44.
ACCESSION   c00044_gnlPro..
VERSION     c00044_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 15:59:08
            Original ID  :: gnl|Prokka|GMCGOJKJ_44
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 22423
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22423
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[7894:21109]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      7895..21109
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     protocluster    1..22423
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[7894:18880]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="2"
                     /tool="gutsmash"
     proto_core      7895..18880
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="2"
     cand_cluster    1..22423
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="chemical_hybrid"
                     /product="Others_HGD_unassigned"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="gutsmash"
     region          1..22423
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             1422..2102
                     /locus_tag="ctg44_1"
                     /transl_table=11
                     /translation="MDTLKILVVDDESRMRKLVKDFLTKKNFQVLEAGNGEEAMDIFYE
                     EKDIALIILDVMMPKMDGWEVCREIRKNSKVPIIMLTARSDERDELLGFDLGVDEYISK
                     PFSPKILVARVEAILRRTGQNNPEDVISAGGIVIDKAAHLATVDGKPMELSFKEFELLT
                     YFLENQGIALSREKILNSVWNYDYFGDARTIDTHVKKLRSKMGDKGEYIKTVWGMGYKF
                     EVDE"
     CDS             2099..3643
                     /locus_tag="ctg44_2"
                     /transl_table=11
                     /translation="MTGTGKTDKKFHTLQHQISVVFICLLLLSIFTITLINGLFLEKYY
                     VSKKVEVLEEAKEVLSQMNLDDILQYDTDIEEDKKGATDEISDEIERSSSRNNLTWIIV
                     NEENSGYYYWGENNMAKMLRSKLFGYINNLDQDMQHSRVLKKTDTCTMWQVHDRFAGME
                     YVECWGQFDNGYYFLIRSPLESIKESASISNSFYFIVGIIIIVISGIVILVMTNRITRP
                     ISELTKLSEKMSDLDFDARYQSRAGNEIDVLGDNFNKMSRKLESTISELKSANNKLQKD
                     IEDKIKIDEMRKEFLDNVSHELKTPIALIQGYAEGLNENISDDPESREFYCEVIMDEAS
                     KMNKLVKNLLTLNQLESGKDAPVMERFDIVSLIRGVLGSMHIMIEQKEATVIFEETEPV
                     YVWADEFKIEEVVTNYTSNALNHLDGERKVEIKVLQEEDCVKVTVFNTGTPIPEEDIPN
                     LWNKFYKVDKARTREYGGSGIGLSIVKAIIESMNQKYGVCNYDNGVEFWFTLDCRQ"
     CDS             3889..4527
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg44_3"
                     /sec_met_domain="GATase (E-value: 5.1e-31, bitscore: 97.8,
                     seeds: 97, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAIIDYDAGNIKSVEKALHYLGEETTVTRDPQTLLNADKVILPG
                     VGSFGQAMENLHTYGLVPVIHEIVEKKTPFLGICLGLQLLFESSEETPGVEGLGILKGK
                     IVKIPPAPGLKIPHMGWNSLHFQNNGRLFQGIPEQTYVYFVHSYYLQAEEPEIVKATTE
                     YSTCIHASVEKDNVFACQFHPEKSSKWGLKILENFATVGKDGNTEKEGK"
     CDS             4529..5287
                     /locus_tag="ctg44_4"
                     /transl_table=11
                     /translation="MFTKRIIPCLDVNNGRVVKGVNFVQLRDAGDPVEIAKAYDAAGAD
                     ELVFLDITASCEQRDTVVDMVRRVAANVFIPFTVGGGIRTVDDFKKLLREGADKISVNS
                     AAIDRPELISEAADKFGSQCVVVAIDAKRREDGGWNIYKHGGRLDTGIDAIEWAKKVEA
                     LGAGEILLTSMDCDGTKAGYDLALTRAIADAVSIPVIASGGAGTLEHFYDALTEGGADA
                     ALAASLFHYKELEISQVKDYLSDRGISVRR"
     CDS             5319..5993
                     /locus_tag="ctg44_5"
                     /transl_table=11
                     /translation="MSAISGDWLEALKGEFHQPYYAKLYKTVMTEYQTRKIFPPADDLF
                     NAFHFTPLNEVKVVILGQDPYHNDGQAHGLCFSVKRGVETPPSLVNIYQELHDDCGCYI
                     PNNGYLEKWAKQGVLLLNTVLTVRAHQANSHRGIGWEQFTDAAIQVLNEQDRPIVFLLW
                     GRPAQMKKSMLNNPKHLILEAPHPSPLSAYRGFFGCKHFSKTNEFLVANGLEPIDWQIE
                     NI"
     CDS             6081..7667
                     /locus_tag="ctg44_6"
                     /transl_table=11
                     /translation="MIAAMISKVIGLLYKSPLSNIIGSLGMGYTSLAQNAYMILLMIAS
                     FSIPQAVSKLISERIALKDYRNAHKFFKGAMIYAMVIGGVVGLFCLFGAGLIIPQNQKD
                     AIPALQILAPTIFLSGILGVFRGYFQAYRNMMPTSISQIIEQVFNAAVSLLAAWGFINA
                     FSDGTENSIAKWGAAGSTVGTGAGVVTALAFMLLVYGVNRRKILHRVEKDHRHQEESYK
                     EIFRVIILVVSPIILSAFVYNVNAYINGYLFSDILGRRGGDAAQIGILYAEYATYFMTI
                     INIPLTLSSTAPTSMIPEVSALYATGDIEATRECIDQTVQLSMVVSAPCAMGLAVLAQP
                     IVFLLYGNSTGLAANLLILGSFSILLNGMSNISNGVLQAIGQQRIPVITAAIALVVDIV
                     VVVVLLFTTNLGVYALLIAMVIYSVVVCVLNDRAMKKYLQYKNPWKEGYLYPVLASVPM
                     GIVAGCICYGLNIFVKSNFICLIVSIPVAAVVYLFAYLIISKPSESQLRRIPGGSYLIR
                     IAEKLPFWQNN"
     CDS             complement(7895..12136)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_7"
                     /sec_met_domain="HGD-D (E-value: 1e-63, bitscore: 205.8,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 2.4e-37, bitscore:
                     118.7, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYKTLGIDIGSTTVKIAILDENENLIFADYKRHFANIQETLADL
                     LQEAFDQYGEMTLHPVITGSGGLTLANHLGVPFTQEVIAVSTSLQKLAPKTDVAIELGG
                     EDAKIIYFENGNVEQRMNGICAGGTGSFIDQMASLLQTDATGLNEYAKDYKALYPIAAR
                     CGVFAKTDIQPLINDGATKPDLSASIFQAVVNQTISGLACGKPIRGHVAFLGGPLHFLS
                     ELRESFIRTLKLDEEHTIIPENSHLFAAIGSALNAKEDSSISLTEMKDRLRNSIKLDFE
                     VERMEPLFASQEEYDAFAKRQSSYKVKTGDLATYKGNCYLGIDAGSTTTKTALVGEDGT
                     LLYSFYSSNNGNPLKTTIRSIKEIYELLPKDAKIAYSCSTGYGEALIKAALILDEGEVE
                     TVSHYYAAAFFDPEVDCILDIGGQDMKCIKIRNKTVDSVQLNEACSSGCGSFIETFAKS
                     LNYTVQDFAKAAVFAQHPIDLGTRCTVFMNSKVKQAQKEGAEVSDISAGLAYSVIKNAL
                     YKVIKVSDASELGRHIVVQGGTFYNDAVLRSFEKIAGCEAIRPDIAGIMGAFGAALIAR
                     ERHQEGAETTMLSIDKINELKYTTSMANCRGCTNNCRLTINKFSGGRQYVSGNRCERGI
                     GKEKNKDHIPNLYEYKYKRIFSYAPLTADKASRGKVGIPRVLNMFENYPFWYTFFTELK
                     YEVVLSPTSTRKIYELGIESIPSESECYPAKLAHGHVTWLIRNGVKFIFYPCIPYERNE
                     FPDAVNHYNCPIVTSYAENIKNNVDELNDPSITFRNPFLAFTSEEILANRLVEEFKDIP
                     AGEVKAAVHKGWEEMAAARRDVQKKGEETLKYLEDTGRHGIVLAGRPYHIDPEIHHGIP
                     DLINSYGIAVLTEDSISHLAPVERPIRVNDQWMYHSRLYAAANYVKTRDDLDLIQLNSF
                     GCGLDAVTTDEVYEILDGSDKIYTCLKIDEVNNLGAARIRIRSLIAAIRAKKAQGQKRT
                     VKPASIDKVSFTKEMRKDYTILCPQMSPFHFSLLQAAFNSCGYNLEVLPNDNKHAVDVG
                     LKYVNNDACYPSLIVVGQIMDALLSGKYDLNKTAVVMSQTGGGCRASNYIAFIRRALKK
                     AGMEQIPVISVNLSGLESNPGFKLTLPLVKKVAYGAVFGDILMKCVYRMRPYELEEGIV
                     NRKHKIWEQRVISFLSGSSISHSQFKKMCREMVHEFDTIPISDVKKPRVGIVGEILVKF
                     LPAANNHLAELLESEGAEAVVPDLIDFMCYCFYNQNFKVENLGFKKSKATMANWGIKAI
                     EWVRKPASEALAQSRHFAPPADIRDLAKMASPIVSTGNQTGEGWFLTGEMMELIHGDVP
                     NIVCIQPFGCLPNHIVGKGVIKEIRREYPTANIVAIDYDPGASEVNQLNRIKLMLSTAQ
                     KNLKKVEEKNA"
     CDS             12335..13513
                     /locus_tag="ctg44_8"
                     /transl_table=11
                     /translation="VIFIKRREKMAEYKLLKTEGRAKRAEFHTVHGTIQTPVFMNVGTI
                     GAIKGAVSTMDLQQIGTQVELSNTYHLHVRPGDKIVKQLGGLHKFMVWDKPILTDSGGF
                     QVFSLAKLRKIKEEGVYFNSHIDGHKIFMGPEESMQIQSNLASTIAMAFDECPSSVADR
                     DYVQKSVDRTTRWLARCKAEMARLNSLPDTINKEQLLFGINQGAVYEDIRIEHAKAISE
                     MDLDGYAVGGLAVGETHEEMYRILDAVVPYLPQNKPTYLMGVGTPANILEGVERGIDFF
                     DCVYPSRNGRHGHVYTNHGKMNLFNAKYELDTRPIEEGCQCPACQHYSRAYIRHLLKAK
                     EMLGMRLCVLHNLYFYNHMMEEIRDALDAGNFAEYKKMRLEGFEEGKINSKR"
     CDS             13762..14061
                     /locus_tag="ctg44_9"
                     /transl_table=11
                     /translation="MNASSGMGMVGAIVWMVVLFGIMYFLMLRPQKKEQKRLQAMLNDM
                     EVGDSIVTTGGFYGVVIDMTEEDVIVEFGNNKNCRIPMRKQAIAEVEKAGSAAE"
     CDS             14196..15332
                     /locus_tag="ctg44_10"
                     /transl_table=11
                     /translation="VRYYNNNYAIRVFLEEIIMDYKIALIPGDGIGPEIVREAKKVLDK
                     VCEKYGHSFSYSEVLLGGASIDEHGVPLTDEAIATAKSSDAVLMGSIGGDAKTSPWYKL
                     EPSKRPEAGLLAIRKALNLFANLRPAYLYNELRKACPLRDEIIGDGFDMIIVRELTGGL
                     YFGERQTIEENGVKKAIDTLSYNENEIRRIAIKAFEIARKRRNKVTSVDKANVLDSSRL
                     WRKVVEEVAKNYPDVTLEHMLVDNCAMQLVRDPKQFDVILTENMFGDILSDEASMVTGS
                     IGMLSSASLNETKFGLYEPSHGSAPDIAGQDKANPIATILSAAMMLRFSLDMDKEADAV
                     EAAVQKVLTEGYRTGDIMSEGCKLVGTKEMGDLIAAAL"
     CDS             15440..17113
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_11"
                     /sec_met_domain="ILVD_EDD (E-value: 8.6e-230, bitscore:
                     753.5, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSDAVKTGTQQAPHRSLFNALGMTKEEMDRPLVGIVSSYNEIVP
                     GHMNLDKITQAVKLGVAMAGGTPVMFPAIAVCDGIAMGHVGMKYSLVTRDLIADSTEAM
                     AMAHQFDALVMIPNCDKNVPGLLMAAARLNVPTVFVSGGPMLAGHLNGHKTSLSSMFEA
                     VGAYAAGKLDEDGLTECEMKTCPTCGSCSGMYTANSMNCLTEVLGMGLKGNGTIPAVYS
                     ERIRLAKHAGMQVMEMYRKNIRPRDIMTKEAILNALTVDMALGCSTNSMLHLPAIAHEI
                     GMDFDISFANEISAKTPNLCHLAPAGPTYIEDLNEAGGVYAVMNELNKKGLLHTECMTV
                     TGKTVGENIKDCVNLNPEVIRPIDNPYSQTGGLAVLKGNLAPDGGVVKRSAVVEEMMVH
                     EGPARVFDCEEDAIAAIKGGKIVEGDVVVIRYEGPKGGPGMREMLNPTSAIAGMGLGSS
                     VALITDGRFSGASRGASIGHVSPEAAVGGPIALVEEGDIISINIPELKLEIKVSDEEMQ
                     ARKAKWQPREPKVTTGYLARYAAMVTSGNRGAILEVPKAK"
     CDS             17189..18880
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_12"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-54, bitscore:
                     174.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLTGAEIIVECLKEQGVDTVFGYPGGAILNVYDALYEYKDQITH
                     VLTSHEQGASHAADGYARATGKVGVCLATSGPGATNLVTGIATAYMDSVPMVAITCNVG
                     TPLLGKDSFQEVDITGIVMPITKHSFIVKDITTLADTVRRAFYIAKSGRPGPVLVDVTK
                     DVTGAKYEYTACAPAEITPKTDTIKDEDIATAVQMIKEAKRPFIFTGGGTIISEASREV
                     TELAHRIDAPVCDSLMGKGGFSGEDPLYTGMLGMHGTKTSNLGVSGCDLLIVLGARFSD
                     RVTGNTKTFAKNAKILQIDVDAAEINKNIVVDASVVGDEKEVLKRILAEVPEMRHSEWT
                     AHISELKEKYPLRYDHSQLTGPYIIEKLYELTKGDAIITTEVGQNQMWAAQYFKYKEPR
                     TFLSSGGLGTMGYGLGAAIGAKMGRPDKTVVNIAGDGCFRMNMNEIATAVRCGRPLIEI
                     VLNNHVLGMVRQWQTLFYDHRYSHTILNDAVDFVKLAEAMGAKAIRITKMEEVEPALKE
                     ALVCPGPIVLDCMIDQDLSVFPMVPAGASIDDIFDEEDMKNNEQSV"
     CDS             18864..19946
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg44_13"
                     /sec_met_domain="Aminotran_5 (E-value: 2.2e-53, bitscore:
                     171.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRVYNFSAGPAVLPEEVLKEVAEEMMDYQGTGMSVMEMSHRSAD
                     FQKIIDEAEQDLRDLMKIPDNYKVLFLQGGASQQFAAIPMNLMKNKVADYIVTGQWAKK
                     AYQEAQKYGKANKIASSEDKTFSYIPDCSDLPISPDADYVYICENNTIYGTKFKKLPNT
                     KGKTLVADVSSCFLSEPVDVSKYGIIYGGVQKNIGPAGMVISIIREDLITDDVLEGTPT
                     MLKFKTQADAGSLYNTPNCYCIYVCGKVFKWLKKMGGLEEMQRRNIEKAKILYDFLDQS
                     KLFKGTVVPEDRSLMNVPFVTGDKDMDAKFVKEAKEAGLVNLKGHRTVGGMRASIYNAM
                     PKEGVEALIAFMKKFEEENA"
     CDS             19946..21109
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: Hacid_dh_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_14"
                     /sec_met_domain="Hacid_dh_C (E-value: 3.2e-45, bitscore:
                     143.6, seeds: 144, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQYHCLNPIAEKGLGLFDEEYKKSEDLQECDAVLVRSAKMHDME
                     LPESVKVIARAGAGVNNIPVKDCAEKGVVVFNTPGANANGVKELVLAGMLLASRDIVGG
                     IEWVAKEKDQEDIDKLAEKQKKQFAGCEIMGKKLGIIGLGAIGAMVANAASALGMEVYG
                     YDPYISIDAAWNLSRTIKHIKSLDEIYSQCDYITIHVPLLDSTKEMINKEALDKMKDGV
                     VLLNFARDLLVDEDALIEALDSGKVKKYVTDFANHTVAGHKGILVTPHLGASTEESEEN
                     CAVMAVKEVRDFLENGNIKNSVNFPNCDMGTCVAVGRIAICHKNIPNMISQFTKILGAE
                     GLNIADMTNKSKGEYAYTLIDLESAASKEALDELKAIEGVSKVRVVK"
ORIGIN
        1 atcccgcata aaatcaaggt atattagaat gtagaattta ctttttcatt caagcacgac
       61 cgcatcaaca aaaaaatcca ggcactggaa gttctgcatc agaaatatga catgttccac
      121 agtttcgtcc gtctttttgg aatgccgggg agacaaaact gggataagaa tctgatacgt
      181 aagagaaaaa aggaaatctc aaaagagctg acagatacga tcagggaaaa gaaattgaaa
      241 agacggaggt gtatggtctg cggaaggaac ctgccatttg gctacccata caaactgtgc
      301 cagccctgct ttgaaaaaaa gaagtttttt gaggattttt ttgagactgt ggatacttaa
      361 atagtgctgt ctcattacaa ttaagagaaa cagacacaaa aaaagagggc taaaaaccct
      421 cttttttgtt taccgttcca acgacacaac taacattccg acattcttat atacaattac
      481 tgtacaaaat tgtcagggtt cgctttgtcg tggtcaagtg gacctggcgg gaattgaacc
      541 cgcgtccgaa agcctattca ttaaggcatc tcccatcaca gtcgctgttt taacattccc
      601 ttggatgtac gcccaccgac aggcttacaa ccttagtagc ttcatgatac atctaccggg
      661 gcaaagctta cccggcaagg tttctcacat ggtcgacgtc agattcctga agtgtgagtg
      721 catcagggct gacgagcagc aattaggctg ctaacgcgta ctgttcgtct gcgtttatat
      781 ttagtttccc ggttggtacg cagtctggga gtctgcggat ggcttcccca acttcaaagc
      841 ccccgtcgaa accagtacaa gccctgaaaa tgagtctgca acgctgtttt ttcataaaac
      901 agcactggtg atgagacgaa agcacttttt aatattgata tatcattcat tatataagat
      961 atatcgactg attaacagta tagaaataaa aacagaattt gtcaagaaga tttttatatt
     1021 tgagactgct tgttactgtt cacttaccat tatcccgcga ggtgttttgg catgaatatg
     1081 ccaaaatccc gagacataca agccaaaatt ccattgccgc aggcaatttg gaatgaattt
     1141 tggctacgtt actgagaacg gagtgaacag taacggctat ttggtgttgt gaacagcaat
     1201 acttataatt tttctgtcat atgttcacaa atcttacata aatctctgct atagtaacca
     1261 tatgaaagat aaaatctgtt gctgagggcg attttcccgg attttgcgct gtggctgtaa
     1321 aggcgctgaa cagtcgtgga ttttaacaat actcggaaaa cagtataaat aaaaagtaaa
     1381 aactgtttcg gaaaataatg aagaaaaacg gaggggatca aatggataca ttaaaaatcc
     1441 tggtggtgga tgatgagagc cgcatgagaa agctggtaaa ggatttcctg acaaagaaga
     1501 atttccaggt actggaagcc ggtaatggtg aagaagccat ggatatcttt tatgaggaga
     1561 aggacatcgc actgatcatt ctggatgtca tgatgccgaa gatggatgga tgggaagttt
     1621 gccgtgagat tcgcaagaac tcaaaagttc cgatcattat gctgactgca agaagtgatg
     1681 agagagatga gcttcttgga tttgatctgg gggtagatga atacatctcc aaaccattca
     1741 gtccgaaaat ccttgttgca agagtggagg caattctgag acgtacaggt cagaataatc
     1801 cggaagatgt gatttcagca ggcggcattg ttatagataa agcagcacat ctggctactg
     1861 tggatggtaa gcctatggaa ctgagcttta aggaatttga acttctgaca tattttctgg
     1921 agaatcaggg aatcgcactt tccagagaaa agattctgaa ttctgtatgg aattatgact
     1981 actttggaga tgcccgtacg attgataccc atgttaagaa gctcagaagt aaaatgggag
     2041 ataaaggtga atatataaag actgtatggg gtatgggata caagtttgag gtagacgaat
     2101 gacaggaacc ggaaaaacag ataaaaaatt tcatactctg caacatcaga tttcagtagt
     2161 gtttatatgt ctgttactgc tttcgatctt taccattact ctgatcaatg gtctttttct
     2221 tgaaaaatat tatgtatcca aaaaagtaga agtgctggag gaggcaaaag aagtgttgtc
     2281 tcagatgaat ctggatgaca tcctgcagta tgatacagat atagaagagg acaaaaaagg
     2341 ggcaacagat gagatttcgg atgagattga gaggagcagt tccagaaata accttacctg
     2401 gatcatagta aatgaggaaa acagcggtta ttattactgg ggagagaata atatggcaaa
     2461 aatgctccgc agtaagctgt ttgggtatat taataatctg gatcaggata tgcagcacag
     2521 tcgtgtgctc aaaaagacag atacctgtac catgtggcag gtgcatgatc gctttgcagg
     2581 catggaatat gtggaatgct ggggacagtt tgataatggt tactatttcc tgatccgttc
     2641 tcctctggaa agtattaagg aaagtgcatc tatttccaac agtttttact tcattgtagg
     2701 aataatcata attgtgatca gcggtattgt gattcttgtg atgacaaatc gtattacccg
     2761 cccgatcagt gaactgacca aattatcaga gaagatgtct gatctggatt ttgatgccag
     2821 atatcaaagc agggcaggta atgagattga tgtacttggc gataacttta acaaaatgtc
     2881 cagaaaactt gagagcacga tctcagagtt gaaatcggct aataacaagc ttcagaaaga
     2941 catagaagat aagattaaaa ttgatgagat gcgtaaggaa tttcttgata atgtttctca
     3001 tgagctgaaa actcctattg cattgatcca gggatatgca gaggggctga atgaaaatat
     3061 ttccgatgat ccggaaagca gggaatttta ctgtgaagtt attatggatg aggcttcaaa
     3121 gatgaacaag ctggtcaaaa acctgctgac gctgaatcag ctggagtccg gtaaagatgc
     3181 cccggtgatg gaaagatttg acattgtatc tctgatcagg ggtgtacttg gttctatgca
     3241 tattatgatc gaacagaaag aagcaactgt gatttttgaa gaaacagaac ctgtatatgt
     3301 atgggcggat gagtttaaga ttgaagaggt tgtgaccaat tatacaagca atgcactgaa
     3361 ccatctggac ggagaacgaa aagtagaaat taaggttctt caggaagagg actgtgtgaa
     3421 agtaaccgta tttaatacag gtactccgat tccagaagag gatatcccaa atctctggaa
     3481 taaattctac aaagtagata aggcccggac aagagaatat ggcggaagtg gtatcggact
     3541 ttcaattgtt aaggcaatca ttgagagtat gaaccagaaa tatggggtat gcaattatga
     3601 taatggcgtg gagttctggt tcactctgga ttgcaggcag tgataagata tccgggtatt
     3661 gtgaacgtag tgagaagagt gttactgtga atggagtgaa cagtaaccgg tagtatgacc
     3721 ggaataaaaa cagacagaag caaagaaagc actttgcaac tgtctgtttt tgggttatac
     3781 tgtattggag cgttttgatc ggatatttta ttccggtctg acatgtgatc cggaaagcct
     3841 tcggattacc ataatgagga aaacagataa tgacatcagg aggataacat gattgcaata
     3901 attgactatg atgccggaaa tattaaaagt gtagaaaaag cacttcatta tcttggggaa
     3961 gaaacaacag taacccgcga tccgcagact ttgttaaatg cggataaagt aatcctgccg
     4021 ggcgtgggaa gctttggaca ggcgatggag aatcttcata catacggact tgtacctgtg
     4081 atccatgaga ttgtagagaa gaagacgcca tttcttggaa tctgcctggg acttcagctc
     4141 ctttttgaaa gcagcgagga gacaccgggg gtggaaggcc ttggaatcct gaaagggaaa
     4201 attgttaaga ttccgcctgc gcccgggctt aagattccac atatgggatg gaattccctg
     4261 cattttcaga ataatggcag actgtttcag ggaatcccgg aacagaccta tgtatatttt
     4321 gtgcattctt attatctgca ggcagaggag cctgagattg taaaggctac tacagaatac
     4381 agcacctgta ttcatgcttc cgtagaaaag gacaatgtat ttgcctgcca gttccatccg
     4441 gaaaagagta gcaaatgggg actgaagata cttgaaaatt ttgctactgt gggaaaagac
     4501 ggcaatactg agaaggaggg aaaataagat gtttacaaag agaattattc cctgcctgga
     4561 tgtaaataac ggacgtgtgg taaagggcgt aaattttgtg cagcttcgcg atgcgggtga
     4621 tccggtggag attgccaaag cctatgatgc agcaggagca gatgaactgg tgtttctcga
     4681 tattacagca tcctgcgaac agagagatac ggtagttgac atggtaagac gggttgctgc
     4741 caatgtattt atcccgttta cagtaggcgg cggtatccgt actgtagatg atttcaagaa
     4801 actgctgaga gaaggagcag ataagatttc cgtaaattct gcagcaattg acagaccgga
     4861 actgatcagt gaggcggctg acaagtttgg aagccagtgc gtagttgtgg ctattgatgc
     4921 caagcgcaga gaagacggcg gatggaatat ttacaaacat ggcggaagac tggatacagg
     4981 gattgatgcc atagagtggg caaagaaagt ggaagctctg ggtgcagggg aaatccttct
     5041 taccagtatg gactgtgacg gtacaaaagc aggatatgat ctggctctta ccagagcaat
     5101 tgctgatgct gtctccattc ctgtgatcgc atcaggcggt gcaggtacac tggagcattt
     5161 ttatgatgca ctgaccgaag ggggagcaga tgctgcattg gctgcgtctt tgttccatta
     5221 taaagaactg gagatttctc aggtgaagga ttatctgtct gacaggggaa tttctgtcag
     5281 acgatgacca cgaaaaatac aagaggtgag gataaggtat gtcagcaatt tcaggtgact
     5341 ggctggaagc cctgaagggg gagtttcacc agccgtatta tgcgaaatta tataaaacgg
     5401 tgatgacaga atatcagacc aggaagattt ttcctcctgc ggatgatctg tttaatgcat
     5461 ttcattttac accgttgaat gaagtgaagg tagtaatcct gggtcaggat ccctatcata
     5521 atgacgggca ggctcatggg ctttgttttt ccgtaaagag aggagtggag acgccgccgt
     5581 ccctggtgaa tatttatcag gagcttcatg atgactgtgg atgctatatc cccaataacg
     5641 gctatctgga gaagtgggcg aagcaggggg tgcttcttct gaacacagtt ctgactgtac
     5701 gcgcccatca ggcaaattca cacaggggga tcggctggga gcagtttacg gatgctgcga
     5761 tccaggttct gaatgagcag gaccgtccta ttgtatttct gctctgggga cgtccggcgc
     5821 agatgaaaaa atccatgctg aataatccga agcatctgat cctggaggca cctcatccaa
     5881 gtcctctgtc tgcttacagg ggatttttcg gatgtaaaca tttcagtaaa acaaacgaat
     5941 ttcttgttgc caatggtctg gaaccaatcg actggcagat agaaaatata taagaaaaga
     6001 ggtaatgtgt agtcaggtaa aagacacaca gtgataacat gaatcagaaa aacaatttag
     6061 taaaaaatgc atcctttctg atgattgcag ctatgatctc caaggtgatc ggtcttctgt
     6121 acaagagtcc cctttccaat attatcggaa gccttggaat gggctataca agtcttgcac
     6181 agaatgccta tatgatcctt ctgatgatcg catcctttag tattccacag gcggtatcca
     6241 agctgatctc cgagcgtatt gctctgaagg attacagaaa tgcacataag ttctttaagg
     6301 gtgccatgat ctatgccatg gtgattggcg gagtggtcgg tttgttctgt ctctttggag
     6361 cagggctgat catccctcag aatcagaagg atgcaattcc ggcacttcag attctggctc
     6421 cgacgatttt tttgtccggt attcttgggg tattcagagg atattttcag gcatacagaa
     6481 atatgatgcc aacatctatc tcccagatca ttgagcaggt atttaatgcg gcagtcagtc
     6541 ttctggcagc ctggggattc atcaatgcat tctcagatgg aacagagaac agcattgcaa
     6601 aatggggggc agcaggttcc acagtaggaa ccggagccgg agtggtgact gcattggcat
     6661 tcatgcttct ggtgtatggt gtaaaccgca gaaaaatcct gcaccgggta gagaaagacc
     6721 acagacatca ggaagagtcc tacaaagaga tttttcgtgt gatcatcctg gttgtttcgc
     6781 cgatcattct cagcgccttt gtttataatg taaatgctta tatcaatggg tatcttttct
     6841 cggatattct gggaagaaga ggtggagatg cggcacagat tggtatttta tatgcagagt
     6901 atgctactta ctttatgaca attatcaata ttcctctgac gctgtccagt acggcaccta
     6961 cttccatgat tccggaagtt tccgccctgt atgccaccgg agacattgaa gcgaccagag
     7021 agtgcattga ccagaccgta cagctttcta tggtagtttc tgccccatgt gccatgggac
     7081 tggcagtgct tgcacagccg attgtatttt tgctttacgg aaattccaca ggactggcag
     7141 ccaacctgct gatccttggt tctttttcga tcctgctcaa tggaatgtca aatatttcca
     7201 atggagttct gcaggcaatc ggacagcaga ggattccggt gattacggct gcaatcgcac
     7261 tggttgtgga cattgtggta gtggtagtgc tgctgtttac tacaaacctt ggagtttatg
     7321 cactgctgat cgcaatggtg atctattctg tggttgtatg tgtgttaaat gacagagcca
     7381 tgaagaaata tctgcagtat aagaatccat ggaaagaagg atatctgtat cctgttcttg
     7441 catctgttcc catgggaatt gttgcaggct gtatctgcta tggactgaac atttttgtaa
     7501 aatccaattt catttgtctg atcgtttcca ttcctgttgc tgcggttgtt tatctgtttg
     7561 cttacctgat tatcagcaag ccgtcagaat cacagcttag aagaattccg ggtggaagct
     7621 atctgataag gattgcagag aaacttccgt tctggcagaa taattaaaca ctgaaattat
     7681 aaaaaacaaa agagttatat ttcatggttt aaatgtagtt ctgaaataga aacacattta
     7741 aaatttctga aatataactc tttttttgag cgcgtttgaa aaatgctttt cgcaaagcag
     7801 gatatgtaga ttgcgggaat gatttttcaa atacgctcta aggcggatat attgcaaggt
     7861 aaaatacatt gcaatatatc cattacggta ttatttatgc atttttttct tctacttttt
     7921 tcagattctt ctgagctgtg gagagcatca gtttgattcg gttgagctgg ttaacttcac
     7981 ttgcacccgg atcatagtcg atggctacaa tattggctgt cggatattct ctgcggatct
     8041 ctttgataac acccttacct acaatgtggt tcggcagaca tccgaaaggc tggatacaaa
     8101 caatattcgg aacatctcca tggatcagtt ccatcatctc acctgtcagg aaccatccct
     8161 cacctgtctg gtttccggtg gaaacgatcg gagatgccat ttttgccaga tctctgatat
     8221 cagcaggcgg tgcaaaatgg cggctctgtg caagagcttc gcttgcaggc tttctcaccc
     8281 attcgattgc tttgattccc cagtttgcca tggttgcctt ggacttcttg aatccaagat
     8341 tttctacctt aaagttctga ttatagaagc agtagcacat gaaatcgatc agatccggta
     8401 caactgcctc agcgccttca gattccagaa gctctgccag atgattattt gcagcaggca
     8461 ggaacttgac aaggatctca cctacgatgc cgacacgcgg cttcttcaca tcactgatgg
     8521 gaatggtatc aaattcatga accatttcgc ggcacatttt tttaaactgg ctgtggctga
     8581 tactgcttcc gcttaagaaa gagatcacac gctgttccca gattttatgt ttcctgttta
     8641 cgattccctc ttccagttca taaggacgca tacgatatac gcatttcatc aggatatctc
     8701 cgaatacggc accgtaagca actttcttca ctaatggaag cgtaagtttg aatccgggat
     8761 tgctttccag accgcttaag ttaacagaga taaccggaat ctgttccata ccggctttct
     8821 ttaatgcgcg tcgtataaat gcgatatagt tggaagcacg acatccgcca cctgtctgtg
     8881 acatgacaac ggccgttttg ttcaggtcat atttaccgga aagcagagca tccatgatct
     8941 gtcccacaac gatcagagac ggatagcagg cgtcattgtt tacatacttc agaccaacat
     9001 ccactgcatg cttattgtca ttcggaagca cctccaggtt gtatccgcag gaattgaatg
     9061 ctgcctgcag gaggctgaaa tggaacggtg acatctgcgg gcagaggatg gtatagtcct
     9121 ttctcatttc ctttgtaaag gatactttat caatagaagc aggtttgaca gtacgtttct
     9181 gtccctgtgc tttcttcgcg cggatcgctg cgatcaggga acggatacgg attcttgcag
     9241 caccaaggtt atttacctcg tcaatcttta agcaggtata gattttgtca cttccgtcaa
     9301 ggatttcata aacctcgtca gtagtaactg catccagacc acatccaaaa gagttcagct
     9361 ggatcagatc cagatcatcg cgtgtcttta catagtttgc ggcagcatac agtctggagt
     9421 ggtacatcca ctggtcgttg acgcggatcg ggcgttccac aggtgccaga tgagagatgg
     9481 aatcctcagt aagtacggca ataccatagc tgttgatcag atccgggata ccatgatgga
     9541 tttccgggtc aatatggtat gggcgtcctg caaggacaat accatggcgt cctgtatctt
     9601 ccagatattt cagggtttct tccccttttt tctgtacatc gcggcgtgca gcagccattt
     9661 cttcccagcc cttatgcaca gcagctttga cttctcctgc cgggatatcc ttaaattcct
     9721 ctaccagacg atttgccaga atttcctcag aagtaaatgc aaggaacgga ttgcggaagg
     9781 taatggacgg atcatttaat tcgtctacgt tattcttgat attttcggca tatgaggtaa
     9841 cgatcgggca gttatagtga ttgactgcat ccgggaactc gttacgttca tatgggatac
     9901 atgggtagaa aataaatttc acgccattgc ggatcagcca ggttacatgg ccatgggcaa
     9961 gtttggcagg atagcattca gattcacttg gaatggactc aatacccagc tcataaatct
    10021 ttctggtgga agtaggagag agcacaacct catacttcag ttctgtaaag aaagtatacc
    10081 agaaaggata attctcaaac atattcagaa cacgggggat acctacttta cctctggatg
    10141 ccttatcagc agtaagcggt gcgtaggaga aaatacgctt atatttatat tcataaagat
    10201 tcggaatatg atctttgttc ttttccttac cgataccgcg ttcacagcgg ttaccgctta
    10261 catactggcg gccgccggag aatttgttga tagtcagacg gcagttattg gtacatccac
    10321 gacagtttgc catagaagtt gtatatttca gctcgttgat cttatcaatg gagagcatag
    10381 tcgtttctgc gccttcctga tggcgttcac gggcaatcag tgcggcaccg aaggcaccca
    10441 tgattccggc aatatccgga cggatggctt cacagcctgc aatcttttcg aagcttcgaa
    10501 gaaccgcatc attgtagaag gtaccaccct gtacaacgat gtgtctgcca agttcggaag
    10561 catcagaaac cttaataacc ttatagagtg catttttgat aacagagtaa gcaagacctg
    10621 cggaaatatc ggatacctca gctccttctt tctgtgcctg ctttaccttg gaattcatga
    10681 aaacagtaca tctggtacca agatctatag gatgctgtgc aaaaacagca gcttttgcga
    10741 aatcctgtac tgtataattc agggatttgg caaaggtttc aataaaggaa ccgcatccag
    10801 aggagcatgc ttcatttaac tgtacgctgt caacggtctt gttgcggatc ttgatacatt
    10861 tcatatcctg tccgccgata tccaggatac agtctacctc cgggtcaaaa aacgctgctg
    10921 catagtaatg ggatacggtc tcaacctcgc cctcatccag gatcagagca gccttaatca
    10981 gagcctcgcc gtaacctgta gaacaggaat aagcgatctt tgcgtctttg ggaagcagtt
    11041 catagatttc tttaatagaa cggatggtag tttttaacgg gtttccgttg ttgctgctgt
    11101 aaaaggaata gagaagtgtt ccatcttcgc ctaccagtgc agttttggtt gtggtggaac
    11161 ctgcatcaat acccagatag cagtttcctt tatatgtagc cagatctcct gtttttactt
    11221 tgtaggaact ctgacgtttt gcaaatgcat cgtattcttc ctgagaagcg aaaagtggtt
    11281 ccatacgttc tacttcaaaa tccagcttaa tggaattgcg gagtctgtct ttcatttctg
    11341 tcagggaaat ggagctgtct tcttttgcat ttaatgcaga accaatggct gcaaaaagat
    11401 gggagttctc cggaatgatg gtgtgttcct catccagctt caaagtacgg ataaaggatt
    11461 ctctcagttc ggacaggaag tgaagcggac cacccaggaa tgcaacatgt ccacgaatgg
    11521 gtttcccgca ggcaagaccg gagatggtct ggtttacaac tgcctggaaa atagaagctg
    11581 acagatccgg tttggttgca ccgtcattga tcagcggctg gatatccgtt ttggcgaaaa
    11641 caccgcagcg ggcagcaatc gggtagagcg ctttgtaatc tttggcatat tcattcagac
    11701 ctgtggcatc tgtctggaga agagaagcca tctggtcgat gaaagaaccg gtaccgcctg
    11761 cacagatacc gttcatacgc tgttctacgt ttccgttttc gaaataaatg atcttggcat
    11821 cctcaccacc aagctcgatg gcaacatctg tctttggtgc cagcttctgc agagaagtag
    11881 aaactgcaat aacctcctgg gtaaaaggaa cgcccagatg gttggcaagg gtcagaccgc
    11941 cggaacctgt gatcacagga tggagagtca tctcgccata ctggtcaaag gcttcctgaa
    12001 gaaggtctgc aagggtttcc tgaatgttgg cgaaatggcg cttgtaatct gcgaaaataa
    12061 gattttcatt ctcgtccaga atcgcgattt ttacagtagt ggaaccaatg tcaattccaa
    12121 gtgttttgta attcataaag taaattcaag cctcctcttt ctgtataaaa gaaaaaatat
    12181 tgaagtaatt ctttcctatt aaaatatcta tttccagata tgaatattcc gtaatattat
    12241 acgctaacgg tctggaaaag acaatatgaa actttaccaa tgattacctt atttgcagtt
    12301 gaaaattcag ctatttcggg atataataga aaaagtgatt tttatcaaga ggagagaaaa
    12361 aatggcagaa tataaacttc ttaaaacaga aggccgtgcc aagcgtgcag aatttcatac
    12421 agtgcatggt acgatccaga ctcctgtttt tatgaatgtg ggaacgatcg gtgcgattaa
    12481 aggcgctgta tccaccatgg atttacagca gatcggaaca caggtagaat tatcaaatac
    12541 ttatcatctt catgtgcgtc cgggtgataa aatagtaaag cagttaggtg gccttcataa
    12601 atttatggta tgggacaaac caatccttac agactcaggc ggattccagg tattttccct
    12661 tgcaaagctg agaaagatca aagaagaggg agtctatttt aactcccata ttgacgggca
    12721 taagatcttt atgggtccgg aagagagtat gcagatccag tccaatcttg cttccactat
    12781 tgccatggca tttgatgaat gtcccagcag tgtggctgac agggattatg tgcagaagtc
    12841 tgtagacaga accacacgat ggcttgcccg ctgtaaagcg gaaatggcga gactgaacag
    12901 tctgccggat accattaaca aagaacagct tctgtttgga atcaaccagg gtgctgttta
    12961 tgaagatatc cgtattgagc atgccaaagc gatctctgaa atggatctgg atggctatgc
    13021 tgtcggcggt ctggcagttg gagaaaccca tgaagagatg tacaggatcc tggatgcggt
    13081 agtcccctat cttcctcaga ataaacctac ttacctgatg ggtgtgggaa caccggcaaa
    13141 tatcctggaa ggtgttgaac gtggtattga cttctttgac tgcgtatatc caagccgtaa
    13201 cggccgccat ggacatgtat ataccaatca tggaaagatg aatctgttca atgcaaaata
    13261 tgaactggac acacgtccta tcgaagaagg ctgtcagtgt cctgcatgcc agcattacag
    13321 cagagcctat atccgtcatc ttctgaaagc aaaggaaatg ctgggaatgc gtctctgtgt
    13381 acttcacaat ctgtatttct ataatcatat gatggaagaa atccgagatg ctcttgatgc
    13441 aggaaacttc gcagaatata agaaaatgcg gctggaaggc tttgaagagg gaaaaattaa
    13501 ctcgaaaaga taatctgtat ataaaataat tattaaatat gccaaaaact cttgaagtaa
    13561 agcggttttt tgtgtatgat gtgtagtgac gctttaatca gattgttctg catgaaaaca
    13621 agatttcata cagaaggtaa cggagattat aagtggatcg caaagcagct cttcagtatg
    13681 agcagccgtc aggacggtct gtgaatacat gatggactgc aaatatgcag aataacagga
    13741 aaagttacag gaggaatcaa aatgaacgca tcaagcggaa tgggtatggt tggcgctatt
    13801 gtctggatgg tagtactgtt cggaattatg tacttcttaa tgcttcgccc tcagaaaaaa
    13861 gagcagaaga gacttcaggc aatgttaaat gacatggaag ttggcgacag cattgttact
    13921 accggcggct tttatggcgt tgtcattgac atgacagaag aagacgtgat cgtagaattc
    13981 ggtaacaaca aaaactgccg tattccaatg agaaaacagg caatcgctga agttgagaaa
    14041 gccggaagcg ctgccgaata atgaaagaga tatgaaaaaa gcggaaccta tagtcagtga
    14101 tggctgtggt tctgtttttt tatttttaca gtaaaatctc cggaaaacag cacttttgta
    14161 ttttttcact ttaataggtt gaaatctgtc ggaaagtgcg ttattataat aacaattacg
    14221 caattagagt atttttggag gaaattatta tggattataa gattgcattg atccccggcg
    14281 acggaatcgg accggaaatc gtaagagaag caaagaaagt actggacaag gtatgcgaga
    14341 aatatggaca cagcttttcc tattcagaag ttctgttagg cggcgcatcc atcgatgaac
    14401 acggcgtacc ccttactgat gaggcaattg ccactgccaa atcatcagac gccgtactga
    14461 tgggctctat tggcggagat gcaaaaactt ctccatggta taagcttgag ccgtccaaac
    14521 gcccggaagc aggacttctt gcaatccgta aggcattaaa tctttttgca aacttaagac
    14581 cggcttacct ttacaatgag ctgagaaaag cgtgccctct ccgcgatgag atcatcggag
    14641 acggatttga catgatcatt gtacgtgagc ttacaggcgg tctgtatttc ggagaacgtc
    14701 agactattga agagaatggt gtgaagaaag caattgatac actttcctat aatgaaaacg
    14761 aaatccgccg tattgccatc aaagcatttg agatcgcacg taagagaaga aataaagtaa
    14821 caagcgtaga taaggcaaat gttctggatt cttccagact ctggagaaaa gtggtagagg
    14881 aagttgccaa aaattatccg gatgttacct tagagcatat gctggttgac aactgcgcaa
    14941 tgcagcttgt acgtgatccg aaacagttcg atgttatcct gacagagaat atgttcggag
    15001 atatcctttc agacgaggca agtatggtaa caggttccat cggaatgctt tcatctgcaa
    15061 gcttaaatga gacaaaattc ggtctctatg agccaagcca tggttctgca cctgatattg
    15121 caggacagga taaggcaaac cctatcgcaa ccattctttc agcagcaatg atgctccgct
    15181 tctcccttga tatggacaag gaagcagatg cagtggaagc agcagtgcag aaggttctga
    15241 cagagggata ccgcacaggt gatatcatgt cagagggatg caagcttgta ggaacaaagg
    15301 aaatgggcga tctgatcgca gcagctctgt aagaattgat attaagagga ttcagccggc
    15361 gcaggcagat tacggagtca ggaatttcgg ttgaatcatt aaaaataaat aaaacagtaa
    15421 gaaaagagga aataaaacaa tgagaagtga tgcagtaaaa acaggcacac agcaggcacc
    15481 tcaccgttcc ctgtttaatg ctcttggaat gacaaaagaa gaaatggaca gacctctggt
    15541 aggtatcgta agttcttaca atgaaatcgt accgggccat atgaaccttg acaagatcac
    15601 acaggcagtt aagcttggtg tggcaatggc agggggtaca cctgttatgt tcccggcaat
    15661 cgcagtctgc gacggtattg caatgggaca cgttggaatg aaatattctc tggttaccag
    15721 agacctgatc gcagattcca cagaagctat ggcaatggca catcagtttg atgcattggt
    15781 aatgattcca aactgtgaca agaacgtacc cggacttctg atggcagcag ccagactgaa
    15841 tgttcctact gtatttgtaa gcggcggccc aatgcttgcc ggacatctga acggacacaa
    15901 gacaagcctt tccagtatgt tcgaggcagt aggtgcttac gcagcaggca agcttgatga
    15961 ggacggactg acagaatgtg aaatgaaaac atgtcctaca tgcggatcct gttccggtat
    16021 gtacacagca aactccatga actgtctgac agaggttctt ggtatgggtc tgaaaggaaa
    16081 cggaaccatc cctgctgtat attccgagcg tatccgtctt gcaaaacatg caggtatgca
    16141 ggttatggaa atgtacagaa agaacatccg tccaagagat atcatgacaa aggaagcaat
    16201 cctcaatgcc ctgacagtag acatggcact tggatgctcc acaaacagta tgcttcacct
    16261 tccggctatc gctcatgaga tcggaatgga ctttgatatc agctttgcaa acgaaattag
    16321 cgcaaagact ccaaacctct gtcaccttgc acctgcaggt cctacataca tagaagacct
    16381 gaacgaagca ggcggtgtat acgcagttat gaacgaactg aataagaagg gacttcttca
    16441 tactgagtgc atgacagtta caggcaagac agtaggcgag aacatcaaag attgtgtaaa
    16501 cttaaatcct gaagttatca gaccgattga caatccatac agccagacag gcggacttgc
    16561 agttctcaag ggtaaccttg caccggacgg tggtgttgta aaacgttctg cagttgtaga
    16621 agagatgatg gtccatgaag gacctgcaag agtctttgac tgcgaggaag acgcaatcgc
    16681 agctatcaaa ggtggcaaga tcgttgaggg tgatgtagtt gttatccgtt atgaaggacc
    16741 gaaaggcggt cctggtatga gagagatgct gaaccctaca tctgcgatcg caggtatggg
    16801 actgggatct tctgtagccc tgatcacaga cggacgtttc agcggtgcat ccagaggagc
    16861 atccatcgga cacgtatcac cggaagcagc agtcggcgga ccgatcgcac ttgttgaaga
    16921 aggggatatc atcagtatta acattccgga actgaaactg gagatcaagg tttccgatga
    16981 agaaatgcag gcaagaaaag caaaatggca gcctcgtgag ccaaaggtaa caacaggata
    17041 tcttgcaaga tatgctgcca tggtaacctc cggaaacaga ggagcgatcc ttgaggtacc
    17101 aaaagcaaaa taaagatgaa caagtacccg gcgggaattg cagcataacc tgtgattcct
    17161 gcctgaaaag ttaggaggat acgtaaagat gcagcttaca ggtgctgaaa tcatcgttga
    17221 atgtttaaaa gaacagggcg ttgacactgt attcggatat ccgggcggtg ccatcctgaa
    17281 tgtatatgac gccctctatg aatataaaga ccagatcaca catgtactga cttctcatga
    17341 gcagggagca tcccatgcag cagacggata cgcaagagca accggtaaag tcggtgtgtg
    17401 tcttgcaact tccggtcccg gagctaccaa tctggtaaca ggaatcgcta ccgcatatat
    17461 ggattctgta ccaatggtgg caatcacatg taacgtggga acaccgctgc tcggaaagga
    17521 ttctttccag gaggttgata ttacaggaat tgtaatgcct attacaaagc acagctttat
    17581 cgtaaaagac attactactc tggcagacac tgtacgcaga gcattctata ttgcaaagag
    17641 cggacgtcct ggtcctgtgc ttgtagatgt gaccaaggat gtgacaggtg cgaaatatga
    17701 atatactgcc tgcgctcctg ctgagatcac accgaaaaca gacaccatca aagacgaaga
    17761 cattgcaact gcagtacaga tgattaaaga agcgaagaga ccatttattt ttacaggcgg
    17821 cggtacgatt atctcagagg catccagaga agtgacagaa cttgctcaca gaatcgacgc
    17881 tcctgtatgt gacagtctta tgggtaaggg aggattttcc ggagaagatc ctctgtacac
    17941 aggaatgctt ggaatgcatg ggaccaaaac ttccaatctt ggtgtctcag gctgcgatct
    18001 cctgatcgtg ctaggagcca gattcagtga tcgtgtcaca ggaaacacaa agacctttgc
    18061 aaagaatgcg aagattctcc agattgacgt agatgctgca gagattaaca aaaacatcgt
    18121 agtagatgca agcgtagtag gagatgagaa agaagttctc aaacgtattc tggcagaggt
    18181 tccggaaatg agacattcgg aatggactgc acatatcagt gaactgaagg aaaaatatcc
    18241 gttaagatat gatcattccc agcttacagg cccatacatt attgagaagc tgtacgaact
    18301 gacaaaagga gatgccatca tcactacaga ggttggacag aaccagatgt gggcagctca
    18361 gtatttcaaa tacaaagagc caagaacctt cctttcttcc ggtggcctgg gaactatggg
    18421 atatggtctt ggagcagcaa ttggtgccaa gatgggaaga ccggacaaga ctgtggtaaa
    18481 tatcgcaggt gacggatgct tccgtatgaa tatgaatgag attgcaacag cagtccgctg
    18541 tggcagacct ttaattgaaa tcgtattgaa caatcatgta ctgggaatgg tacgtcagtg
    18601 gcagaccttg ttctatgacc acagatattc ccatacaatt ttaaatgatg cagtagattt
    18661 tgtgaagctg gcagaagcca tgggagcaaa agcaatccgt atcacaaaga tggaagaggt
    18721 agagcctgca ttaaaagagg ctctggtatg tccgggacct atcgtacttg actgtatgat
    18781 cgatcaggat ctcagcgtat tcccgatggt accggcaggc gcaagcattg atgatatttt
    18841 tgatgaggag gatatgaaaa acaatgagca gagtgtataa tttttccgca ggaccggctg
    18901 tactgccgga agaggtactg aaagaagttg cagaggagat gatggactat cagggaactg
    18961 gtatgtctgt aatggaaatg agccacagaa gtgctgattt ccagaagatt attgacgaag
    19021 cagaacagga tctccgtgac ctgatgaaga ttccggataa ctataaggta ttattccttc
    19081 agggcggagc ttcccagcag ttcgcagcaa tccctatgaa ccttatgaag aacaaggtag
    19141 ctgattacat tgtaacagga cagtgggcaa agaaagcata ccaggaagca cagaaatatg
    19201 gaaaagcaaa caagatcgct tcttccgagg ataagacttt ctcctatatt cctgactgca
    19261 gcgaccttcc gatcagcccg gatgcagact atgtatacat ttgcgaaaac aacacaatct
    19321 acggaacaaa attcaagaag cttcccaaca caaaaggaaa aactctggta gcagatgttt
    19381 cctcctgctt cttatctgag cctgttgatg tatccaaata tggcatcatc tatggcggtg
    19441 tacagaagaa tatcggacct gctggtatgg taatctccat tatccgcgaa gatctgatca
    19501 cagacgatgt tctggaagga acacctacta tgctgaaatt caaaacacag gcagacgcag
    19561 gttctcttta caatactcca aactgctact gcatctatgt atgcggtaag gtcttcaaat
    19621 ggctgaagaa aatgggcggc ctggaagaaa tgcagagacg taacattgag aaagcgaaaa
    19681 tcctctatga tttccttgat cagagcaagc ttttcaaagg aactgttgta ccggaagacc
    19741 gttctctcat gaatgtacca ttcgtaacag gtgacaagga catggatgcc aaatttgtaa
    19801 aagaagcaaa agaggcagga cttgtaaact taaagggaca ccgtacagtg ggcggtatgc
    19861 gtgcaagcat ctacaacgct atgccaaaag aaggtgtgga agcactgatt gctttcatga
    19921 agaagtttga ggaggagaat gcataatgtt tcagtatcat tgcctgaatc ccattgcaga
    19981 aaaaggtctg ggattatttg atgaagaata taagaaaagc gaagatctgc aggagtgtga
    20041 tgcagtcctt gtaagaagtg caaaaatgca tgacatggag cttcctgaga gcgtaaaggt
    20101 aatcgcacgt gcaggtgcag gtgtcaacaa tattcctgta aaggactgtg cagaaaaagg
    20161 tgtggtagta ttcaatacac cgggcgccaa tgcaaacggt gtaaaagagc ttgtacttgc
    20221 aggtatgctc cttgcttccc gtgatatcgt aggcggtatc gaatgggttg ccaaagagaa
    20281 agaccaggaa gacatcgata aacttgctga gaagcagaag aagcagtttg caggatgcga
    20341 gatcatgggc aagaagctgg gtatcatcgg tcttggtgcc atcggagcaa tggtggcaaa
    20401 cgctgcttct gcacttggaa tggaagtata cggatatgac ccatacattt ctattgatgc
    20461 tgcatggaat ctttcccgca ccatcaaaca tatcaagagc ctggatgaga tttattccca
    20521 gtgtgattac atcaccatcc atgtacctct tcttgacagc acaaaagaga tgatcaacaa
    20581 agaagcatta gacaagatga aagacggcgt agtacttctg aactttgccc gtgatcttct
    20641 ggttgatgag gatgctctga tcgaagcatt agacagcgga aaagtaaaga aatatgtgac
    20701 agactttgca aaccatacag tagcaggaca taagggaatc ctggtaactc cacaccttgg
    20761 agcatctaca gaagaatccg aagaaaactg tgcggtaatg gctgtaaaag aagtcagaga
    20821 tttcctcgag aacggaaata tcaagaactc tgtaaacttc ccgaactgcg acatgggaac
    20881 ctgcgtagca gtaggacgta tcgccatctg ccacaaaaat atcccgaaca tgatcagcca
    20941 gttcaccaag atccttggtg cagaaggtct gaacattgca gatatgacaa ataagagtaa
    21001 aggtgaatac gcatatactc ttatcgattt ggaaagcgca gcctccaaag aagcactgga
    21061 tgagctgaaa gcaattgaag gcgtttccaa ggtacgtgtg gtaaaataat agtcagacca
    21121 tattattaac aagataaaaa atctcctgct ttaattacat gattgtaatg agcaggagat
    21181 tttctacatt gaaaccgccg tgtactgaat ggtacgcatg gtggtagtgt gccatgcttg
    21241 tttggtttat ttatcgtttg ctgcctatcc atcggcagat ataatgtgca actatatctc
    21301 cggcgagaat agcaaagaag agagcaacat atttcatcat ggattcacct ctttctgatt
    21361 aagatcacag atagttactg ttcactccgt tcacagtaac ttagccaaaa ttcattccag
    21421 attgcctgcg gcaatggaat tttggcttgt atgtctcggg attttggcat attcatgcca
    21481 aaacacctcg cgggatagtg gtgtgtgaac agtaaccaca gatacattat atcatacatc
    21541 agacaaaaaa agagattgac tttttacggg aagtagaata ttataaatac agctaagaaa
    21601 agtgattata tttgtcatag gcaaagcaaa aaccccagga gtgtgcgaga ctcctggggc
    21661 tttttgttcc gtttatgtaa ggtggcttat acctttaggc tgttactgcc tgtcgttcct
    21721 gtccaaccat ttgcaaacga agtagctaac aacatttgcc gtaacagaaa caagaaaagc
    21781 gattataaaa tctgtcatag gacttcacct cctttctgct ggaggttcgg cagcttttaa
    21841 attatatcac agcttagaac aaaacggaac tcagtatgtc actttttctt tatttctcaa
    21901 aaagtgcccc tctgaaatgc gcagcatcca gagaagcact ggatgagctg aaagcaattg
    21961 aaggtgtttc cagagtacgt gtagtaaaat aagaaacatt gatctgaaaa agtaataaaa
    22021 aatctcctgt gatgcagttg caatcacagg agatttttta ttactttact ataaactatt
    22081 ttttgacttt gaattttttt atatcggaat atggactgta aactctggat ttatccttgg
    22141 aggtcttatt ccaggaacgt actgtcacat accaggtgcc tttctttacg tttgtaaagg
    22201 ttacagttac ggtatttttg ccttctgtac gtttcagata tttcttaacc gggtatttct
    22261 cacctgcgga ggttttgtat ttgtttccaa gcaggatttc ataacctgtg gcatttttgc
    22321 attttgtgta agtaatagtc acagtgtttc cttctacagt aatattcctg atctttggct
    22381 gctgtggtgt gacaacagtg atcttgatct tcttgatctt tgt
//
