LOCUS       gnlProkkaKCOEMNOA_88   14907 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KCOEMNOA_88.
ACCESSION   gnlProkkaKCOEMNOA_88
VERSION     gnlProkkaKCOEMNOA_88
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 09:53:40
            Original ID  :: gnl|Prokka|KCOEMNOA_88
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14907
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14907
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3395:4907]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3396..4907
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14907
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14907
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(112..1260)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg88_1"
                     /sec_met_domain="Peptidase_M16 (E-value: 4.1e-08, bitscore:
                     23.4, seeds: 24, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYRWFDFGEKKIPYYKKEIGENSDLLHCALSIKKGSMQDYIAGT
                     AHCLEHMMIENEHVSSINWDLVDRWAHTDFYETTYYFYASVENFEYIYDIIQGILSGDW
                     LKKNVFSNIWPGIIEEYSNEISKVDNAKKKALFSKSIYEEKMPIGVCDSIYKIQYEDIE
                     NYFIENYLKSIPVFIVAGDTIRFEKMYKEKIVSGEYDVMKDRVNCMPLSFDNDLIIKNM
                     EVTHIYINVDIEQRPIFYQYEALYVRAYIAANCMNFILKKELGHNLHFIECRLVRLSKG
                     FCLIDIMFKKTIYDNFKIIGLIKNIKWWGYLDYIYKEIHLFMKQYCKVIGTNLGNTVNK
                     ILNHTIYGANYIEDRSLFQIRAEDIITFLEGLALYHKFRIVV"
     CDS             complement(1273..3063)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 166.9; E-value:
                     1e-50)"
                     /gene_kind="transport"
                     /locus_tag="ctg88_2"
                     /transl_table=11
                     /translation="MRMKNIKEYTAIIVKVIKLSYLSSKKYTIILWGINIMIGIAFPIS
                     TFIWSIFIDKATIGILSNEWKIAALWLGGYSIFWFIQNILNVINEYIENILSAKLNIYT
                     TDKIMKCIADLPMEYFDKSENYDKIQKVNTESNMRSMSIIKTLINLIQGILTMLGTVII
                     LLQVNWIILIILFFLCIPTLVLSLNLSFEKYNIYNARVKDMRFISFLKNMMSEYENIKE
                     LRVNLSSEFFINYIDKKYREFLKVDRKIQSKYSFKMIGMDCIEQIIICSMRIYLLINVV
                     IRNMSIGQLSLHINSIDNFRNSIITILNTMASIYEDGLYVNNLFEFLEIKNNIMRENQK
                     YIQEISKVEFRHVWFKYPNTEKYILEDINFVIEKGKSYSFVGLNGSGKTTIIKLILNLY
                     NPTRGEILVNDINLSNIDMEEYLSKIGVVFQDFMKYPLTISENISIASVRQMNNKNKIE
                     KAAKLSGADQFINKLPKKYDTSLFREWEDGVQLSIGQWQKIAISRAFLEDFPVIILDEP
                     TASLDAYAEFELYKKFKDIVKNKTSILIAHRFSTIKLADLIYVIKNGKIIESGSHNELM
                     KLNGEYAYLYRIQSDAYVSK"
     CDS             complement(3141..3347)
                     /locus_tag="ctg88_3"
                     /transl_table=11
                     /translation="MKLVNPLGRTVDTLESKADYVSPRSGCVCSGPSGTAASHNKGSGW
                     CVGYCGGETTETRHENMLNAKTA"
     CDS             complement(3396..4907)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg88_4"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     1.5e-13, bitscore: 41.0, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 1.1e-08,
                     bitscore: 25.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 7.6e-14, bitscore: 42.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.9e-10, bitscore: 29.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRLYNAIPVKNYKSLGTVFETTSGLYVYDTGTGKVFSCNEVTYN
                     LFKIIFSGGDTNEIYEKYSAQEINKSISEIIEMIQKENILQASYSEFDRETDFELEAIY
                     NYSLQSLILEVTQKCNFRCKYCIYHSFNEYYRNYGLQDMNWETAKKAIDYVSRHSGEKE
                     LSIAFYGGEPLINYDVMKKTIEYSEMVMPKKTLIFAFTTNLSLMTLEKAKFFAKHNCYI
                     MCSLDGPKIIHDAYRVDIKGDGTFNKVIEGLKNLLIAFGDRAKTHIKFNVVICPPYSRK
                     KLDAIKEFFDKLDYLPAGIDIKYSYVESGSLRKEDIDYTYFPEGEDIIGDVPPIDIWLT
                     EELPKQSSDQNVIFTLARDALARVHKRFLLDHPCEKMKRNGCCIPGGRRIYVDIKGNIA
                     LCERVGKSPSLGNINKGIDLEQVKRYYLEEYEKASVEQCKNCWAVNLCNMCYAACYREN
                     GIDIEAKNELCTYQKDQLKGELIMYHQVLETNPELLEHIQDIEII"
     CDS             complement(5343..5543)
                     /locus_tag="ctg88_5"
                     /transl_table=11
                     /translation="MEITFLIQQTLIDGIDVGSGTHYARAFCWCNYEYSKKLFAFSNDE
                     VGALHLKARWTIQLRNHDNWK"
     CDS             complement(6005..7282)
                     /gene_functions="other (smcogs) SMCOG1229:transposase
                     (Score: 275.3; E-value: 1.1e-83)"
                     /gene_kind="other"
                     /locus_tag="ctg88_6"
                     /transl_table=11
                     /translation="MPNTVKVLKLTTDEKNSLECLLRCPTTEARKYIRAKILLLKSDSY
                     TNEAIADKLDITVPTVRLCLQKYFAGGIDNALNDCKGKGRKQEISDDDITWVVNKACQK
                     PLDYGFSAEFWYPASFTRFIQSIAVKEGHPRLEHVSEFSLRKILANAKIRPFKVTYYCE
                     KRDPDFDSKMHNVLVIYKQVSLQFDKDGNLLPFEGTPVHTLSYDEKPGIQAIGSTTPDL
                     PPISNTEKGSSYMRDYEYIRYGTISLLAAIDLLTGEAIPLVSDTHKSSDFVEFLTRLDA
                     KYPEGDKIRLILDNHSAHTSQETQRYLNNHLGRFEFVFTPTHGSWLNLVEGFFSKLTKQ
                     MLQGIRVASKEELSERIYKYFDEINQIPIPYHGSYNLDSIDLATEDIDQIVYEVVNAKA
                     ASEELSCKRAPKPIKRSPKKSAKTEN"
     CDS             7562..7654
                     /locus_tag="ctg88_7"
                     /transl_table=11
                     /translation="MQKWDFQNNDCRNIKSSKTEGTVLITKVSR"
     CDS             7728..8069
                     /locus_tag="ctg88_8"
                     /transl_table=11
                     /translation="MNKEEKAKLWSDRIQQYQTSGQTCKQWCTENGIPLSTMGYWIRRF
                     AKEEPASESEQDMVFVRLPSEQEAARKLLSEESSSVRIFISDSIRIEISDSCRMELMES
                     ILGFLQRHA"
     CDS             8568..9728
                     /locus_tag="ctg88_9"
                     /transl_table=11
                     /translation="MEPIFTDKQLNNMSREDLISLMKIVQEQTKKKDTEIQLLKEKQKE
                     LEFLNAMLSDRLTLAQRKQFGASSEKYAEGYEQMNLFNEAEASADAETEELFEEIRPSS
                     YKRKKRKGKKEEDLSNFETVETRTYKLEGEARYCPECGKKYNVVTKEIVKRLRFVPAKF
                     AVEEEITYVYSCPKCGSMKRPEKEPSLIRGSIATPSLVAGIMNAKYVNGMPLARQEREF
                     ARYDLDLSTKTMANWIINCADRYLKPLYQLMKEELLESRYIHCDESRIQVLGEPDQEGT
                     TQNWMWVYLTDESSGSPQMVLFDYERTRAGYHPVNFLGNRFRGYLTCDGYQAYHSLGEG
                     IIVSGCLTHARRRFDAALTALKKRLHKRTAERDRCISGDVKDRDPL"
     CDS             9739..10215
                     /locus_tag="ctg88_10"
                     /transl_table=11
                     /translation="MIHNKTPEEKYEERQKQSRPVMDALFEWLHTMEDSVDRSSLIGDA
                     ILYTLNQEVYLRRYLEDGHLSIDNNSAERALKNFAVGRRNWLFAKSVRGADASALVYSI
                     TETALLNNLKPYAYLTYILDELRKMGAFPKEEELKKLLPWSEYLPEYCRTKLKK"
     CDS             complement(10457..11797)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 132.5; E-value: 4.2e-40)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg88_11"
                     /transl_table=11
                     /translation="MGLITYNFIMIFTPQTYLDKINKNIDSVLNETIGQFSDMTMSQCK
                     VKLLNLTKSYDIMINLTDEKGREIEFGSDMQYTADYQDVRWKIRTNIEKKYTFKPKNES
                     DTYYIYVLSDGERVNLYIDSLKEILPELIILILFISLVLSILYAKHVAVPVIRISELAR
                     KLADLNFVNYVDTGRKDELGRIEESLYELSERLSVALSELENANENLREEIEKERNMEK
                     QQLSFFSSASHELKTPITALKGHLQGMLYDVGEYKEHRKYLKRCLDIIENMQKLETEIM
                     SSAKIRSSGFKMNISKFDLRMLVIEVINEYEDVAMHRGITIQDELGDEVAYIKADYDLL
                     KRAVSNIISNAIRYSPENGNIKITIDDNEKAERLSVINQGSQIPENQIQKMFLPFARLE
                     ESRNKETGGSGVGLYLVKMILDLHKFSYCLRNKEANSIEFEILFFYK"
     CDS             complement(11850..12515)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 209.1; E-value: 1.1e-63)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg88_12"
                     /transl_table=11
                     /translation="MHNILIVEDDKDIQETLEFFLKDNGYMTDKASNGIEAIDKFETNK
                     FDLILLDIMLPKVDGYAVCENIRKKSQIPIIIISALSSEENQIKGLDLQADDYIIKPFS
                     IPILLRKISAIFRRNKYNEEIGVLIYKNVKLDLDSYKAFVSDKEVMLTKREFEILHELI
                     LNQGKILTREILMERVWQYEYIGNARIVDNHIKNIRKKIGDEVIKTIRGVGYKVDKIY"
     CDS             12924..14027
                     /locus_tag="ctg88_13"
                     /transl_table=11
                     /translation="MNTTARIALKLIPNSLQTQPVFLCVDDTMVSKFGTKFENVSKLFD
                     HAAHNGSNYLNGHCFVSVMLCVPVWNHDKVSYLSVPLGYRMWQKKESKLELAASMIRQV
                     MPEFHGKEHVIILCDSWYTKQNLVSVIDEYPNLDLIGNARTDSVMYDLEPARTGHRGRP
                     AKHGKRLSVETDFTFSNEKIGDYYTGVRRVLTRIFGTREVLAYVTAAEKEHGTKRLFFS
                     TVFPEDLQIFCAWQEKAPLNQTGSDRMKYIPLFLYSFRWNIETSYYEQKTFWSFCSYMV
                     RSCKGMEMLVNLINISYCAMKILPYQNEHFSEYRTKSVQEFRFELSQGIRSQIFFATFV
                     KNIETHIKSNAMTRALKQLVCQQVYHL"
     CDS             complement(14215..14460)
                     /locus_tag="ctg88_14"
                     /transl_table=11
                     /translation="MEQIADFIKQLYEYYYLKKNEIKKLQKNISPELLASFGRQLTKTE
                     DTKVELHKAVLNLAKKVMPDKRKTQIYAHFLEKESV"
ORIGIN
        1 agggcttagg aacaaatgtt ttgtacaatt tttaattttc aaacacgctc tagcgtagcg
       61 gattcttctt ataacaaaaa atattcctat agaatcatat ctcgcatata cttatactac
      121 tattctgaat ttatggtaca gtgccaatcc ttctaaaaat gtaattatat cttcagccct
      181 aatctggaat aaacttctat cctctatata gtttgcacca taaatagtat gatttaaaat
      241 tttatttaca gtgttcccta ggtttgtacc tataacttta cagtattgtt tcataaacaa
      301 atgtatttct ttataaatat agtctaaata cccccaccat tttatattct taattaaccc
      361 tatgatttta aaattgtcat atattgtttt cttaaacatt atatcaatta agcaaaatcc
      421 cttagataat ctaactaatc tgcattcaat aaaatgtaag ttatgtccta attctttttt
      481 cagaataaaa ttcatacaat ttgcagcaat atatgctctt acatataaag cttcatactg
      541 ataaaaaata ggtctttgct caatatctac atttatatag atgtgtgtta cctccatatt
      601 ttttattatc aaatcattat caaatgataa tggcatacaa tttaccctgt ctttcataac
      661 gtcatattca ccagatacta ttttttcttt atacattttt tcaaacctta ttgtatctcc
      721 tgctactata aatactggta tagatttcaa atagttttct ataaagtagt tctcaatatc
      781 ttcatactga attttatata tggaatcaca cacccctata ggcatttttt cttcataaat
      841 tgatttacta aacagtgctt tcttttttgc attatctact ttactaattt catttgaata
      901 ttcttcaatg atacctggcc atatattact gaaaacgttt ttctttagcc aatctcctga
      961 gagaatacct tgtataatat cgtagatata ctcaaaattt tcaacacttg cataaaaata
     1021 ataggttgtc tcataaaaat ctgtatgtgc ccatctatcc acaagatccc agttaataga
     1081 agaaacatgt tcgttttcaa tcatcatgtg ttcaagacaa tgtgctgttc cagcaatata
     1141 atcctgcatt gacccttttt ttatagataa agcacaatgt aacaagtccg aattctcacc
     1201 aatttctttt ttataatatg gtattttttt ctcaccaaaa tcaaaccacc tatatttcat
     1261 aatccccttc ctttacttac taacatacgc atctgattga attctatata gatatgcata
     1321 ttctccgttc agtttcatca actcattgtg actacctgat tctatgattt ttccattttt
     1381 tataacataa atcaaatcag ctaactttat cgtagaaaag cggtgagcta ttaatatact
     1441 tgttttattt tttacaatat ctttaaattt tttatatagc tcaaactctg catatgcgtc
     1501 taaagatgca gttggttcat ccaatataat tacagggaag tcttctaaaa acgctctact
     1561 tatagcgatt ttttgccact gtcctattga aagttgtact ccgtcttccc attctctaaa
     1621 taatgaagta tcatatttct ttggaagctt gttaataaat tgatctgctc cagataactt
     1681 tgctgctttc tcaattttat ttttattatt catttgtctg actgaagcaa ttgatatatt
     1741 ttcgcttatg gttaacggat atttcataaa gtcttgaaat actacaccga ttttggataa
     1801 atattcctcc atatcaatat tactcagatt aatatcattt acaagaatct ccccacgtgt
     1861 aggattatat aaatttaaaa tcaattttat tattgtggtt ttacctgaac catttagccc
     1921 aacaaaagaa taactttttc ctttctcaat tacaaaatta atatcttcta aaatatactt
     1981 ttccgtatta ggatatttaa accatacatg ccgaaattct actttgctga tttcctgaat
     2041 atatttttga ttttctctca taatattatt ctttatttcc aaaaactcaa ataaattatt
     2101 cacatataat ccatcttcat aaatagacgc cattgtattt aatatagtaa ttatcgaatt
     2161 tctaaaatta tctatagaat taatatgcaa tgataattgt ccaatgctca tatttctaat
     2221 aacaacattt attaataggt aaatccgcat actacatatt attatttgtt caatacaatc
     2281 cattccaatc attttaaaag aatatttact ttgaatcttt ctatcaactt ttaagaactc
     2341 tctatatttt ttatctatat aattaataaa aaactcagat gacaaattca cgcgtagttc
     2401 ttttatattt tcatactccg acatcatatt ttttaagaat gaaataaatc tcatatcctt
     2461 aactctagca ttataaatat tatacttttc aaacgataaa ttcaaactta gtactaatgt
     2521 aggaatacat aaaaaaaaca atattatcaa tataatccaa ttaacttgaa gtagaataat
     2581 tacggttccc agcatagtaa gaataccttg aataagatta attaaagtct taattatact
     2641 catagatctc atattagatt ctgtgttaac cttttgtatt ttatcataat tttccgactt
     2701 atcaaaatat tccatcggta aatcagctat acacttcata atcttatctg tagtataaat
     2761 attaagtttt gcagacaaaa tattctctat gtattcattg ataacattaa gtatattctg
     2821 aataaaccaa aaaatagaat acccccctag ccataatgca gctattttcc attcattact
     2881 caaaatgcct atagtagctt tatctataaa tatactccaa atgaacgtac taataggaaa
     2941 cgctatacct atcataatat ttattcccca taaaataatg gtatactttt ttgaactcaa
     3001 ataagatagt ttaattactt ttactattat agcagtgtat tctttaatat ttttcattct
     3061 cattttctaa ccccaatcta aataaggaag agatactatt gggtacctca ataatatctc
     3121 ttcctctagt ccagcaactt ttatgctgtt ttagcgttca gcatgttctc atggcgtgtt
     3181 tctgtagttt ctcctccgca atatcctacg caccaacctg aacctttatt gtgacttgct
     3241 gctgttccag aaggaccaga gcatacacag cctgatctag gactaacata gtccgctttg
     3301 ctttccaaag tatcgaccgt tcttcctaaa gggttcacta atttcatgtt cttacctcct
     3361 taaaaattta ttgttatatt attaataata ataacctata taatttctat atcctgaata
     3421 tgttcaagca attcagggtt tgtttccagt acttgatgat acattataag ttcacctttt
     3481 aactgatctt tttgatatgt acataattca ttctttgctt ctatatctat accattttcc
     3541 ctataacagg ctgcatagca catattacat agattgactg cccaacaatt tttacattgt
     3601 tctacagaag ctttttcata ttcttccaaa tagtatcttt ttacttgttc caaatctatt
     3661 cctttattaa tatttcctaa agaaggagat ttaccaaccc gctcgcataa cgcaatattt
     3721 ccttttatat caacataaat acgacggcca ccaggtatgc aacaaccatt tcttttcatt
     3781 ttctcacaag gatgatccaa cagaaatctt ttatgtacac gtgccaatgc atctcgtgca
     3841 agtgtaaaaa taacattttg atctgatgat tgttttggaa gttcttccgt aagccatata
     3901 tctataggtg gtacatcccc tataatatct tccccttcag ggaaatatgt ataatcaata
     3961 tcttctttac gtaaacttcc actctcaaca tacgaatatt ttatgtcaat tcctgcaggc
     4021 aagtagtcta acttatcaaa aaactctttt attgcatcca atttttttct cgaatagggt
     4081 gggcatatga caacattaaa ttttatatgg gttttagcac gatctccgaa tgcaataaga
     4141 agatttttta acccctcaat cactttattg aatgttccat caccttttat atccacccta
     4201 taagcatcat gtataatttt aggaccatct aaactacaca ttatatagca attatgttta
     4261 gcaaagaatt ttgctttttc taaggtcatt aatgataaat ttgttgtaaa tgcaaagatc
     4321 aaagtttttt tcggcataac catctcacta tattcaatag tttttttcat cacatcataa
     4381 tttattaacg gctctcctcc gtaaaaagcg attgataatt ctttttcacc cgaatgtcta
     4441 cttacataat ctattgcttt ttttgctgtt tcccagttca tatcctgtaa gccataattt
     4501 ctataatact cattaaaact atgatatata cagtacttac atctaaaatt acacttttgt
     4561 gtaacttcaa ggataagact ttgtaatgag taattataga ttgcttccag ttcaaaatct
     4621 gtttctcgat caaattctga gtacgatgct tgtagtatat tttccttttg tatcatttca
     4681 attatttcag atattgattt gttgatttcc tgagctgaat acttttcata tatttcgttt
     4741 gtatcgcctc cagaaaaaat tattttaaac aaattgtaag taacttcatt gcaactaaaa
     4801 acttttcctg tcccagtatc atatacatat aatccactag tcgtttcgaa gactgtccct
     4861 aagcttttat agtttttcac tggaattgca ttatatagtc tcttcatatc acccatcttt
     4921 tttctcccta tatagtcaag tctttttttc tttaaaatca aggattttta atgtttcatc
     4981 aatcaatatc tcagaaaaag gaaccatagg aatggacatt tctctgtatc tggtacgaaa
     5041 gtagtgaatt gggggcgaag taaaatgtct tcttttttcg ttctacataa cttagtgtat
     5101 ccccatccat ctacggcaac aaactcccat gtctactagc attatcagac tattgctgaa
     5161 tcctatcttc tctccttcct cttttccata accagggtgt cagctcagct tctttacagg
     5221 gtctttgccc atggaaaata ttcctgccaa ctatcggctc attctttttt attgtattac
     5281 tgacctcttt cctgtaacag tactttctgg tgagcatttt tctgttacaa tatatttgct
     5341 tgttacttcc agttatcatg atttctcagc tgtatcgtcc atctagcctt taaatgaagc
     5401 gctccaactt catcgttgct gaatgcaaac agcttctttg agtactcata attacaccaa
     5461 caaaaagccc ttgcataatg agttccactt cccacatcaa tcccatcaat taaagtttgc
     5521 tgaattaaaa aagtaatttc cacaatatat acaattttta cgttctatgt gttataattc
     5581 atttcaagta cctcactgtt taataagatt tttactaacc gctcaaagtc agtaatctta
     5641 ttttactctg agtttttttc aaccttcttt ctcggaattc cttatatttg aattatacaa
     5701 gaagctcctt tcttggtatt attatagcag acaaatttcg ctttttattt cttgatacat
     5761 ttatacacta atttaatcaa aaaaaactga ctgtgttcac tacaatgcct aaagaataac
     5821 tatccagctc ttttcgttta ttcatttttt aaagctagtt cttccaatat cctattgaaa
     5881 aaaggtactg catttcaaaa acgtccatta ccatcatcct tatctttcgt tgaaaaatac
     5941 caagccgttt atgattatct ggagaaggaa acaactctac gagaactagt ataatccgtt
     6001 ttaattagtt ttctgttttg gcagactttt taggacttcg ttttataggc ttaggtgcac
     6061 gtttacaact cagttcttcc gatgccgcct tggcattgac aacttcatac acaatctggt
     6121 caatatcctc tgtagctagg tcgatactat cgagattata agacccatgg tatggaatag
     6181 gaatctgatt aatctcatca aagtatttat aaatccgctc cgacagttct tccttgctgg
     6241 caacacgtat accttgaagc atttgctttg tgagtttgct gaaaaaacct tctaccaagt
     6301 taagccagga accatgagtt ggtgtgaata caaactcaaa ccttcctaaa tggttattta
     6361 aatatcgctg tgtttcctgc gatgtatgtg ccgaatggtt gtcaaggatg agacgtattt
     6421 tatcaccttc aggatatttt gcatccaacc gtgttaggaa ctccacaaaa tctgaacttt
     6481 tgtgggtatc actcaccagt gggattgcct ctcctgtaag aagatctatc gccgccagta
     6541 acgatatagt accatagcgg atatactcat aatcccgcat atagctgctg cctttctctg
     6601 tattactaat cggcggcaga tctggagttg tggagccgat tgcttgtatt cccggtttct
     6661 cgtcatagga taacgtatgg acaggggttc cctcaaaagg tagcagattc ccgtctttat
     6721 caaactgcag tgaaacctgc ttataaatta caaggacatt gtgcatcttt gaatcgaaat
     6781 caggatccct tttttcgcag taatatgtga ctttaaaagg acggattttg gcattggcaa
     6841 gaattttcct gagagaaaat tctgaaacat gttctaacct tggatgccct tccttcacag
     6901 caatagactg tataaaacga gtaaagctgg cgggatacca aaattcagca gaaaaaccgt
     6961 aatccagcgg cttctggcag gctttattga ccacccatgt gatgtcatca tcggatattt
     7021 cctgcttgcg accttttcct ttgcaatcgt ttaaagcatt atcaataccg ccagcaaaat
     7081 atttctggag acataagcgg acggtaggca cggttatatc aagcttgtcg gcaatggctt
     7141 cattggtata agaatcactt tttaataaca aaatctttgc ccggatatat tttctggctt
     7201 ccgttgttgg acatcgaaga agacactcta aagagttttt ttcatccgtt gtaagcttca
     7261 gcacttttac tgtatttggc atcgtatcat tcccctttca ttatgggaat agtataccat
     7321 acttcaaaca taaagacaat taaaatggat tatactagga ctagaatata gtgtaatcac
     7381 taccagtatt cgcaaatgaa ttacaagtta caaagcgggt gaggatactg cactgatgcc
     7441 tgttcactct aaaaaacatt acaacagacc attcaaactg aaagttttac tgtcatatct
     7501 ttctggagaa agcaaccatt ctgagtttac tggcagtttc aaaatatcgt cttttaaaac
     7561 tatgcaaaaa tgggattttc agaataacga ttgtaggaat ataaaaagtt ctaaaacaga
     7621 aggaactgtg ctcataacaa aagtaagtag gtaatcatcc gtatctgttt tttcgttttt
     7681 tattctgcta caatctcctt gaaactcagg aggtattcta tatcactatg aataaagaag
     7741 aaaaagcaaa actctggtct gaccgtatcc aacaatacca gaccagtgga caaacatgta
     7801 aacaatggtg tacagaaaac ggtatccctt tatctacgat gggatactgg atccgcagat
     7861 ttgcaaaaga agagccggca tccgagtctg aacaggatat ggtctttgtc agacttccat
     7921 ctgaacagga agctgccaga aagctgctct ctgaggaatc ttcatcggtg cgtattttta
     7981 tttcagacag tatccgtatt gaaatatctg attcctgcag aatggaactg atggaatcta
     8041 tactgggatt cctgcagcgc catgcttgac ctggcaggag ggacaacggt atatctctcc
     8101 tgtggtgtca ctgatctaag aaaaagttac aatggtctgg cggctatcat caaattaaaa
     8161 tttcacctcg acccatactc acgctgcatg tttgcgttct gcaaccgtcg gcgtacttct
     8221 ataaaaatcc ttcaatggga cggatccgga ttctggatcc tgatgaaacg gctcgaccgt
     8281 aatgccttcc actggccgga tactccggac gaactccgtc aggtgactct gaaagagatc
     8341 cactggctgt gtgacgggct ctccttaaat cccagggatg catttgagga acaccatcca
     8401 aagatcatcc tgtaagcata agacagcgga gctgtcaatc ccgtaaaaat catgaaaaac
     8461 atggcatttc ccagcgtatt tcctatatcc gtaagcgcag ttttttatag gaaaacagct
     8521 ggaaccatga tatactttta ataacgctaa agcagggaga acaggatatg gaaccgatct
     8581 ttacagataa acaactgaat aacatgagcc gggaagatct gatctcattg atgaagatcg
     8641 tgcaggagca gacaaagaaa aaagataccg agatccagct gctgaaagaa aagcagaaag
     8701 aacttgaatt cttaaatgcc atgctctctg accgccttac ccttgcacag aggaaacagt
     8761 ttggtgcatc cagtgaaaaa tatgccgaag gctatgaaca gatgaacctg ttcaatgagg
     8821 cagaagccag tgcggatgca gaaacagaag aactttttga agagatccgg ccatcctctt
     8881 ataaacgtaa aaaaagaaaa ggaaagaagg aagaagacct ttccaatttt gagaccgttg
     8941 agaccaggac ctataaactg gaaggggaag cccgttactg tccggaatgc ggaaaaaaat
     9001 acaatgtagt aacaaaggag atcgtaaaac gcctgcgctt tgtacctgca aagtttgcgg
     9061 ttgaagaaga gatcacttat gtatacagct gcccgaaatg cgggtccatg aaacgtccgg
     9121 aaaaagaacc ttccctgatc cgtggaagta tcgctacgcc ttcccttgtc gccggtatca
     9181 tgaatgctaa atatgtaaat ggaatgcctc tggcacgtca ggaaagagag tttgccagat
     9241 atgatctcga tctctccaca aagactatgg cgaactggat cataaactgt gcagacagat
     9301 acctgaaacc gctgtatcag ctgatgaaag aagaacttct ggaaagcaga tatatccatt
     9361 gtgacgaaag ccgtatccag gtactcggag aaccggatca ggaagggacg acccagaact
     9421 ggatgtgggt atatctcacg gatgaatcca gtggttcccc gcagatggta ctcttcgatt
     9481 atgaaaggac ccgtgcggga tatcatcctg taaacttttt agggaacagg tttcgtgggt
     9541 atctgacctg tgatggatat caggcttatc acagtttagg agaaggtatc atagtaagcg
     9601 ggtgccttac ccatgcaaga cgacgttttg atgcagccct cacagcatta aaaaaaagac
     9661 ttcacaaaag aacagctgaa agagaccgtt gcatatcagg cgatgtcaag gatcgggatc
     9721 ctctataaga tcgaggagat gatccacaat aaaacaccgg aagaaaaata tgaggagcgc
     9781 cagaaacagt cccgtccggt tatggatgcc ctgtttgaat ggctgcatac gatggaagat
     9841 tctgtagaca ggtcttccct tattggtgat gccattttgt atacgcttaa tcaggaagta
     9901 tatctgaggc gttatctgga agatggtcat ctcagcatag ataacaacag tgcagaacgc
     9961 gcattgaaga actttgcagt gggacgccgc aactggctgt ttgccaaaag tgtacgggga
    10021 gctgatgcca gcgcccttgt ttacagcatt acagaaacgg cacttctgaa caatctgaaa
    10081 ccatacgcat atctgaccta tatattggat gaactcagaa aaatgggagc ttttcctaaa
    10141 gaggaagaat taaagaaact gcttccatgg tcagagtatc ttccggaata ctgccggact
    10201 aaactaaaaa aataatacta agccatctga tataggaact ggcaaatcca gccaggaaca
    10261 gtatcagatg gcttttataa gatgtcaata tacgaatgat tacctactta catctgatat
    10321 agaatctggc agacagccag gaacaatatc agatggcttt tataaaatgt caatatacgg
    10381 atgattacct acttactaaa ctttactaaa tcattactgt gcactgcaat atattataga
    10441 aaataacaat aaattcctat ttataaaaaa ataatatttc aaattctatg ctatttgctt
    10501 ctttattacg caagcaataa gagaacttat gtaaatcaag aatcatcttt actaaatata
    10561 atcccacccc actaccacca gtctctttat ttcgcgattc ttccagtcta gcaaatggta
    10621 aaaacatttt ctgtatttga ttttctggta tttgacttcc ctgattaata acacttaaac
    10681 gctctgcttt ttcattgtcg tctatcgtta ttttgatatt tccattttca ggagaatagc
    10741 gtattgcatt actaataata ttactaacgg ctcttttcaa caaatcataa tctgctttaa
    10801 tatatgcaac ttcatctccc aattcatctt ggatagttat ccccctatgc atagcaacat
    10861 cttcatattc attaataact tctattacca acatccttag gtcaaatttt gaaatattca
    10921 tcttgaatcc agaagatctg atttttgctg acgacattat ttctgtttct aacttttgca
    10981 tattttcaat aatatccaga catcgtttta aatacttacg atgttcctta tattctccca
    11041 catcatataa cattccttgt aaatgtcctt ttaatgcagt aatcggtgtt tttaactcat
    11101 gtgaggctga tgaaaaaaac gaaagttgct gtttttccat attcctctct ttttcaattt
    11161 cttctcgcaa attttcgttt gcattttcta attcactaag cgcaacgctt aaacgttctg
    11221 atagctcata caaactttct tctattcttc ccaattcgtc tttccgaccc gtatcaacat
    11281 aattaacaaa gttaagatct gctagttttc tagccagctc tgaaattctt atcaccggaa
    11341 ccgctacatg tttcgcgtat aatattgaca acaccaaaga aataaatagt attaaaatga
    11401 taagctctgg caatatttct tttaatgagt ctatatagag atttactctt tcaccatccg
    11461 aaagtacata tatataatat gtgtcacttt catttttagg tttaaacgta tattttttct
    11521 ctatatttgt tcttattttc catctaacgt cttgataatc tgctgtatac tgcatatcac
    11581 ttccaaattc aatttctctc cctttctcat ctgttaaatt tatcataata tcataacttt
    11641 ttgtcaaatt taacaattta accttacact gactcattgt catatcagaa aactgaccga
    11701 tcgtctcatt taaaacagaa tctatatttt tatttatttt atctaagtat gtctgaggtg
    11761 taaaaatcat aataaaatta taggtaatca gccccatact aatttgcata attagtgtaa
    11821 gaaaaaagac ctgtacgctt aaatgagatt taatatatct tatcaacctt ataccctact
    11881 cctctaatag tcttaattac ttcatcacct atttttttcc taatattttt tatatgatta
    11941 tctacaatcc ttgcattacc tatatattca tactgccata cgcgttccat taatatttct
    12001 ctagttaata ttttcccttg attcaaaata agttcatgta aaatttcaaa ttctcttttc
    12061 gtcaacataa cttctttatc actaacaaat gccttatagc tatccaaatc caacttgaca
    12121 tttttataaa tcaaaacacc tatttcctca ttatatttat ttcttctgaa aattgcactt
    12181 attttacgta gcaaaatcgg tattgaaaaa ggcttaataa tataatcatc cgcttgtaaa
    12241 tctaatcctt ttatttggtt ttcttcactt gaaagtgcac ttataataat tatgggaatc
    12301 tgagattttt ttctaatatt ctcacagaca gcataaccat caactttagg cagcattata
    12361 tctaataata taagatcaaa tttattcgtc tcaaatttat ctattgcttc aattccatta
    12421 cttgctttgt ctgtcatata tccattatct ttcaaaaaaa actctaatgt ttcttgtata
    12481 tctttatcat cttcaacaat taaaatatta tgcataagtt attcctcttt ctaattcata
    12541 gaaacattag taacaaataa taaaatgact attcactaca ccactttaca actttttcat
    12601 aaaaaaatat cgtacaggac tttctgatgt ataatgaatt tggcaaaaaa cattacaaag
    12661 gaaagtgacc ctgtacgaca aaaatattat acaacgaaaa aacactgatt ggtagacttc
    12721 atcaatattt tttgatttat tttgaaactt tttctgttcc aacagcagat accctgtttc
    12781 tgttgatatt atccatactg gctttggaat ccgcgcattc catccgtttt ctttatcagc
    12841 attttttatc cggggtaaca gaaaaatcac tgaatgtatt ttattatgca tgttcctatg
    12901 caaaagttga ttattccaga tttatgaata ccactgcccg gattgctttg aagctgatac
    12961 cgaattcatt acagacgcag ccggtatttc tgtgtgttga tgatacaatg gtatctaaat
    13021 ttggcacaaa gtttgaaaac gtttcaaaac tgtttgacca tgctgcacac aatggttcca
    13081 actatttgaa tggacattgc tttgtgagcg tcatgctctg cgtgcccgtc tggaatcacg
    13141 ataaggtatc gtacctttct gttcctctcg gttatcgtat gtggcagaaa aaagaatcaa
    13201 aactggaatt ggccgcatcc atgatccggc aggttatgcc agaatttcac ggcaaagaac
    13261 atgtcattat tctttgcgac agctggtata caaaacagaa cctggtatct gtcattgatg
    13321 aatatccaaa cctggatctg attggtaatg caaggactga ctctgtcatg tatgatcttg
    13381 agcctgcgcg cactggacac aggggacgtc ctgctaaaca tggcaaacgc ctttctgttg
    13441 agacagattt tactttttcc aatgaaaaga ttggagatta ttataccggt gtccgccggg
    13501 ttctgaccag gatctttggt acccgtgaag tccttgcgta tgtcactgcc gctgaaaaag
    13561 agcatggcac aaaacggctg ttcttcagca ctgtttttcc agaagatctg cagattttct
    13621 gtgcatggca ggagaaagca ccactgaacc agacaggcag tgaccggatg aaatacattc
    13681 cactctttct atactcgttt cgctggaata ttgaaacgag ctactatgag cagaaaacat
    13741 tctggtcttt ttgcagctat atggtgcgaa gctgcaaagg gatggagatg ctggttaacc
    13801 tgattaacat cagttactgt gctatgaaga ttctgcctta tcagaacgag catttttctg
    13861 agtaccgcac caagagtgta caggagtttc gttttgaatt aagtcagggt attcgcagtc
    13921 agatattttt tgccactttc gtgaaaaata tcgaaacaca cataaaatca aatgctatga
    13981 caagggcttt aaaacagttg gtttgtcagc aagtctacca tttataaagt tgtaaactgg
    14041 tgtattcact attaatctct ataaaataat tatattacat ttttacggct tgtcaagatt
    14101 ttcccttgga taccagcttc gaaaggtaaa tttattttat agcctgccaa ttttgtaaat
    14161 ccacatattt acacattttc ttataaattt agaaaagtta ttcacattga atgattatac
    14221 ggattccttc tctaaaaaat gtgcataaat ttgtgttttc ctcttgtcag gcatcacctt
    14281 ctttgctaag tttagaactg ctttatgcaa ctccactttt gtatcttctg tttttgttag
    14341 ttgacgtcca aagctggcta acaattcagg agatatattt ttttgcagtt tttttatttc
    14401 atttttcttc aggtaataat attcataaag ctgctttatg aaatctgcta tctgctccat
    14461 cagataatgg ttcttttgtg cctgttcatt ccaactgcat gcatgctcta tatttccctg
    14521 ccaatgcttc tggcggttaa atgttttcta ttttccatct gttccttccg gctttcacaa
    14581 ttttctttgc attgcttttg gtaattgtga tatttgtaat ccatgcaaat tttgttattt
    14641 tttcttcccc atctgcctga attttctttt ctgtataata tatcagattt acatctgtat
    14701 tctgaaacat aatctgattc tggtattcta tttctgaacc tatcttttct ttttcaggca
    14761 gttcttgata ttcctgtgct atggatggtg cacatccttc tttataacgg atgatataat
    14821 cccagccatt atccgtacag gtttgtataa ccttctggct gacatacaat ccatcggctg
    14881 ttattataat cggaagcctc ggaaaac
//
