LOCUS       c00110_gnlPro..        12951 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KCOEMNOA_110.
ACCESSION   c00110_gnlPro..
VERSION     c00110_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 16:07:01
            Original ID  :: gnl|Prokka|KCOEMNOA_110
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12951
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..4434)
                     /locus_tag="ctg110_1"
                     /transl_table=11
                     /translation="MKHNFKLKERLGALLLAMLFILQAILGLVPVCVTQAAPLTVETWD
                     SDKVVDYGYRFNMKFQPGITTYESFGCDNLDREAFSDNGKSERDTECVRVGADYKAGSA
                     GMRYNNVGKDGDGNIVDVRLILVGVENAEPRYDLRTAESIVQNKGGATFAWKDNEAYPM
                     VGFSKNSIGVFIYSVGYAKVKFQFLKHRTEETLPISGHGTIRDIDAGQGVRIPSDSSLD
                     NAYVLKNNDYLTVDGNSVSSPLGSVEPDDPRGWLNLFYDTDNFTIEFCHQFRLDKWDKS
                     REDAIAKAGSQERWAEITRNKYLDPSGNSYCPNFKGQKYCKAYAYFDFTSYCFGDVEMK
                     KAPEKRVGEANCTWEQAAAVSKEKPFGIRQGQEFQYMIRAEVTPNRLKSFVVQDILEDC
                     LTIEDASKVSIVNDAGQTVTDWFDVAVEGQKVTCRAKAESLQDEAFTDNQTYTFTLKVR
                     QRPESEINISKYLAEDGYSILVPNHASMSYERTNGSGDTMDTETVWVKGVIPPELEVKK
                     NTSQYEWKTGDIIDYEVLVSQTKQDVKAVNVVITDELPSCLQLLEGQYAVETSQGGENC
                     TLTGQGENGWKAECPSLKYGETITIRFKCQASADSNGQEWENIVTATADNLINPETGEQ
                     ESRKDMAEVWPNSPQLEIDKTADKYEWQAGEQVAYRIVVNNVTAGTIAKDVTITDIGLP
                     QGLVLAGGAQSMEVLGVQQQVNYPVPDKKTGQAYEARPVDSQLNADENGFSFYCSYVPY
                     SQPVTIIFHCIAQEEANGHESVNAATVKAANTDERSDDAEVYVNSGEFWIEKSADHYEW
                     QVGEQVQYNVVVENKKAGTVARNVTVWDTGMPAGLALSSAEDVSVSGIPQNITQLTAGT
                     KDVLNQLNPEFYNETSEKPVNYEFLQEGSGWRLNISDLPANTPVMISFLCTVTEAANGM
                     ESINVANVQAQNAPVSQDDAEVYVNTAVLSIGKSFQNPYLAAGDGRAENEFRVGEQVNY
                     QVTVNNLQKGSIARNLVISDLSLPEGLALDGAEDAVTVSGVPAVIQNPVAGTDDAGNQL
                     NPENYKETVEKPVSCQVTRQGTGWIVTISDLPYQTPVTVNFRCTAQESVNGMEIVNTAQ
                     AYADNAQKVKDSSKIWVNSPVLKVEKTTDKPFYKYGDIITYRIVLTQEQTGCVARNVTL
                     QDMIDTQGVRLLKDSVILMDEKGNVADADVQINDDNTFLMSTGRTLVRDSRYSICDNDK
                     GGLFEQVMYNPLDCQEQKSMIVEYQAAVIDAALAGQKVHNTAVADSSEKIPATGEAETE
                     VHSPILEIVKESDKKEYVSGEKGYYKLTVRQLREDVTDQNIVIEDKLETQGAFIVKDSI
                     FVKKNGIELKDAKIEADDTGFVIQTGASLSDMDKIEVCYELVFKTESTEPEKIVNTAKA
                     RGDISPETAAQQEVYVKAKAEPTVTPTPSATPKPTETPKPTETPKPTEVPKPTEQPKVT
                     PTPSVPGTCPKMTPVPT"
     protocluster    1..12951
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[7440:10689]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      7441..10689
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..12951
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12951
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(4638..5099)
                     /locus_tag="ctg110_2"
                     /transl_table=11
                     /translation="MNRKEFLEILRSQLAGQMQEGKAAAHIRYYEDYIQSQVRGGRSEQ
                     EVLQELGAPHLIAKTLIDTDDGSTQEDYGEYSSYGSSYGNETEFPHQQEKRWKKVIDLS
                     TWHGRAVVIAAAAVIIVLLILIIGVAIPFFIILAIILYFLSWLKKRNDQ"
     CDS             complement(5323..6201)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg110_3"
                     /sec_met_domain="CN_hydrolase (E-value: 1.4e-56, bitscore:
                     180.7, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNVTVAAVQMKCSKSVEKNIAHAEELVRQAAAKGAEIVLLPELF
                     ERPYFCQERRYEYYEYAQTAEENPAVRHFSRVAAELGIVIPVSFYEKEVNNTYNSVAVL
                     DADGKNLGVYRKTHIPDDHYYQEKFYFTPGDTGFKVFDTRFGTIGVGICWDQWFPETAR
                     CMALQGAELLFYPTAIGSEPILECDSMEHWRRCMQGHAASNLIPVIAANRIGEETVEPC
                     PENGMQKSALNFYGSSFITDNTGALCAELPGGEEGVLVSTFDLDALKADRLNWGLFRDR
                     RPEMYAKIVGK"
     CDS             complement(6282..7493)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg110_4"
                     /sec_met_domain="PAD_porph (E-value: 8e-129, bitscore:
                     418.5, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VRLSDISGTKTLRAGFPDICLAIREKETDMEVTEKNRTKYRMPGE
                     FEPHEGCVMIWPERPGSWNYGAREAQKAFVKVAEAIGESEKVYMLVSKAQMENAKNQLG
                     NVSGVTLLECETDDAWARDVGATMVLDEKGAVCGVDWQFNAWGGTFDGLYRNWEKDDRV
                     AAFICRTLGCPCLDARPFVLEGGSIHSDGEGTLIVTEACLLSQGRNPQMSREQIEEQLK
                     YWLGVHKIIWLPCGIYQDETNEHVDNVCAFVRPGEVVLAWTEDETDPQYAMSLADLKVL
                     EQETDAKGRKFKIHKLPIPQKPVCLTREDVDGFVFEEGEDEREAGERMAASYVNFYISN
                     GGIILPQFGDENDKRAVEILQKCFPKRRIYPIDARAIIVGGGNIHCITQQIPGKISDLD
                     AEKL"
     CDS             complement(7441..8562)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg110_5"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 3.5e-15,
                     bitscore: 45.3, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDQLQTPCYVIDEKKMRENLEILKKVQEDTGCKILLAQKAFSG
                     FALYPMIGKYLAGTTASGLFEARLGYEEMGKENHVFSPAYRTEDMAELDRICDHIIFNS
                     TAQLKKFKEVCTGASLGLRINPECSTQGDHAIYDPCAPGSRLGVTRENFDGECLKWIDG
                     LHFHTLCEQNADDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYDVKRLEKCIRH
                     MKETYDLDIYLEPGEAIALNAGYLVTEVMDIVENGIRTLVLDASAACHMPDVLEMPYRP
                     PLKDSGEAGEKAYTYRLSSCTCLAGDVIGDYSFDREIRIGDKLYFMDMAIYSMVKNNTF
                     NGMPLPDIAVMHEDGECEVIRHFGYEDFKSRLS"
     CDS             complement(8552..9832)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg110_6"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 3.1e-44, bitscore:
                     141.1, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 1.4e-36,
                     bitscore: 114.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLLVIGCGGVASVAIRKCCQNSDVFTEIMIASRTKEKCDALKE
                     KIESTTKTKIETAKVDADNAAEVAELIRAYKPDAVLNVALPYQDLTIMDACLEAGADYI
                     DTANYEAEDTEDPTWRAIYEKRCKEKGFTAYFDYSWQWAYDEKFKEAGLTALLGTGFDP
                     GVTSVFSAYALKHYFDEIHTIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWEDGH
                     WVETEPMEFKSVYDFPEVGKKDMYLLHHEEIESLAKNIPGVQRIRFFMTFGQSYLTHMK
                     CLENVGMLSTAPVEFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGKEK
                     SIYIYNVCDHQECYKEVESQAISYTTGVPAMIGSMMVVTGQWKKPGVFNVEEFDPDPYM
                     EALNKWGLPWKVCEDPELVKVWKANED"
     CDS             complement(9829..10689)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg110_7"
                     /sec_met_domain="Spermine_synth (E-value: 2.5e-54,
                     bitscore: 172.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 3.7e-16,
                     bitscore: 48.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFV
                     ALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDV
                     VESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKARYDLIINDSTDPLGHT
                     EGLFTKEFYGSCYKALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHI
                     PTCPSGYWLFGFASKKYHPLEDFRPERFDNLNIETWYYTTNLHRGAFMLPKYVEDLLEE
                     EENSL"
     CDS             complement(10692..12149)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg110_8"
                     /sec_met_domain="OKR_DC_1_C (E-value: 2e-14, bitscore:
                     43.2, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 4.4e-127,
                     bitscore: 413.0, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYERQQHAPIYEALERFRKKRVVPFDVPGHKRGRGNPELAQLLG
                     EKCVGLDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSAVQSMILSVC
                     KAGDKIILPRNVHKSAINALVLCGAIPVYVNPEVNAQLGISLGMEVSQVEKAMDENPDA
                     VAVLVNNPTYYGICSDLRTIVKKAHARGMKVLADEAHGTHLYFGRNLPVSGMAAGADMA
                     AVSMHKSGGSLTQSSLLLLNKSMNAEKVRQIINLTQTTSASYLLLSSLDISRRNLALRG
                     EESFEKVAGMAQYAREEINEIGGYYAYGMDLINGTSVFDFDVTKLSIYTLGNGLAGIEV
                     YDLLRDEYDIQIEFGDICNILAYISIGDRLQDIERLVGALADIERLYKKDSTGMLSGEY
                     IAPAVVASPQQAFYAEKESLPMEQAAGRISGEFVMCYPPGIPILAPGEMVTQEIVEYIL
                     YARDKGCSMQGMEDPKVEHLQVLKGGI"
ORIGIN
        1 cgtcggtaca ggagtcattt tcgggcaggt tcccggtaca gatggtgttg gtgtgacttt
       61 tggctgctct gttggtttcg gtacttctgt tggttttggt gtctctgtcg gctttggtgt
      121 ttctgttggt ttcggtgtgg cagacggtgt tggtgtgaca gtgggttctg cttttgcttt
      181 cacatatacc tcctgctgcg cagcagtttc cggtgaaata tcacctcttg ctttcgctgt
      241 gtttacaatt ttttcaggct ctgtgctttc tgttttaaat accagttcat aacagacttc
      301 aattttatcc atatctgaca acgatgctcc tgtctgaatt acaaatcctg tatcatctgc
      361 ctctattttg gcatctttca gttctatacc gtttttcttc acaaaaatgc tgtcttttac
      421 aatgaaagcc ccttgggttt ccagtttatc ttcgataaca atattctgat ctgtgacatc
      481 ctcacgcagt tgtcttactg tcagtttata gtatcctttt tcaccggaca catactcttt
      541 cttatctgat tccttcacaa tttccagaat cggactgtgt acctctgtct ctgcttcccc
      601 ggttgcaggt atcttttcac tgctgtctgc aactgcagta ttgtgcactt tctgtcctgc
      661 cagggctgca tcaatcactg ctgcctgata ttccacgatc atacttttct gttcctgaca
      721 gtccagagga ttatacatta cctgctcaaa aagaccgcct ttatcattat cgcagatact
      781 atatctgcta tccctgacca gtgtcctgcc tgttgacatc aggaaagtat tatcatcatt
      841 gatctgtaca tcagcatctg ccacatttcc tttctcatcc atcagaatca ccgaatcctt
      901 cagaagacgt actccctgag tatcgatcat atcctgcaga gtaacattac gcgccacaca
      961 tccggtctgc tcctgtgtca ggacaatgcg gtatgtaata atatcaccat atttgtaaaa
     1021 tggtttgtcc gtcgtcttct ctactttaag aacaggcgag ttcacccaga tttttgagga
     1081 gtcctttact ttctgtgcat tatctgcata cgcctgtgct gtatttacaa tctccatccc
     1141 atttacgctt tcctgcgcag tacagcggaa attaacagtc acaggtgtct gatacggaag
     1201 atctgaaatc gtcacgatcc atccggttcc ctgacgtgta acctgacagc tgaccggttt
     1261 ttccactgtt tctttataat tttccggatt cagctgattt cctgcatcat cagttcctgc
     1321 caccggattc tgaataacag ccggaacacc gcttacagta acagcatctt cagctccgtc
     1381 cagagccagc ccttcaggaa gggaaagatc actgatcaca agatttcttg cgatagatcc
     1441 cttctgaaga ttattaaccg taacctgata attcacctgt tctcctaccc gaaattcatt
     1501 ttccgcacgt ccgtccccgg ctgccagata tggattctga aaacttttcc caatagaaag
     1561 aactgctgta tttacataca cttctgcgtc atcctgtgaa acaggggcat tctgcgcctg
     1621 cacattggca acattaatgc tttccattcc atttgccgct tccgtaactg tgcaaaggaa
     1681 agaaatcata accggagtat ttgccggaag atctgaaatg ttcagtctcc atccgcttcc
     1741 ctcctgaaga aattcataat tcaccggttt ctctgatgtc tcattataaa attccggatt
     1801 gagctggttc aaaacatctt tggtccctgc tgtcagctgc gtaatattct gtgggattcc
     1861 gcttaccgat acatcctctg ccgatgaaag cgcaagtcct gccggcatac cggtatccca
     1921 gacagttacg ttccgggcca ctgtacctgc ttttttattc tccaccacca cattgtactg
     1981 tacctgttct ccgacctgcc attcataatg atctgcagat ttctcaatcc agaattctcc
     2041 tgaatttaca tatacttctg catcatcaga tctctcatct gtattagcag cttttacagt
     2101 tgctgcattt acgctttcgt gtccatttgc ctcttcctgt gcgatacaat ggaaaataat
     2161 cgttacaggc tgactgtatg gtacataaga acaataaaag gaaaatccgt tctcatctgc
     2221 attcaactga gaatccacag gtctcgcttc atatgcctgt cctgttttct tatccggtac
     2281 gggatagttt acctgttgct gaactcccag tacttccatg ctctgtgcac cacctgccag
     2341 aaccagtccc tgcggcagac caatatcagt aatagttaca tcttttgcaa ttgttcctgc
     2401 cgttacatta ttcaccacga tccggtaagc tacctgctct cctgcctgcc attcatattt
     2461 gtctgctgtt ttatcaattt caagctgtgg actgttcggc catacttctg ccatatcctt
     2521 tctggattcc tgctctcctg tctcaggatt gatcagatta tccgctgttg cagtcacaat
     2581 attttcccat tcctgtccat tggaatccgc agatgcctga catttaaaac ggattgtgat
     2641 cgtctcccca tacttcaggg acggacactc tgctttccat ccattttctc cctgtccggt
     2701 aagcgtacag ttttcacctc cctgacttgt ctctacagca tactgccctt ccagaagctg
     2761 cagacatgat ggaagctcgt ctgtaataac aacatttact gcttttacat cctgttttgt
     2821 ctgagaaacc agaacctcat aatctatgat atctcccgtt ttccattcat actgagaagt
     2881 atttttcttt acttccagtt ccggtggaat cacacccttt acccacactg tttccgtatc
     2941 cattgtatct ccgcttccgt ttgtacgttc ataactcatg gatgcatggt ttggtacaag
     3001 aatactgtat ccatcctctg caaggtattt tgaaatgtta atttctgatt ccggtctctg
     3061 gcgtactttt aaagtaaatg tgtaagtctg attatctgta aatgcttcat cctgaaggct
     3121 ctctgctttg gccctgcagg tcactttctg tccttcaaca gcaacatcaa accagtctgt
     3181 cactgtctgc cctgcatcat tcacaatact gacttttgat gcatcctcta tagtaagaca
     3241 atcctcaagt atatcctgta ccacaaagga tttcagtcta ttgggtgtca cctccgcccg
     3301 gatcatatac tgaaattcct gtccctgacg aatgccaaaa ggtttttctt ttgatacggc
     3361 agctgcctgt tcccatgtac agtttgcctc tcccacacgt ttctcaggcg cttttttcat
     3421 ctcaacatca ccgaaacaat aggatgtaaa atcaaaatat gcatatgctt tgcagtattt
     3481 ctgtccttta aagttcggac aataactgtt gcctgatgga tccagatatt tatttcttgt
     3541 aatctctgcc catctttcct gagaaccggc ttttgcaatg gcatcttcac gacttttatc
     3601 ccatttatcc agtctgaact gatgacagaa ttctatcgta aaattatctg tatcataaaa
     3661 aagattcagc catcctctcg gatcatccgg ctcaacggaa ccaaggggtg agcttacaga
     3721 attcccatct accgtcagat aatcattgtt tttcagaaca tatgcattat ccagactgct
     3781 gtctgacgga atacggactc cctgtcccgc atcaatatca cgtatggttc catgtccact
     3841 gatcggcagt gtttcttctg ttctatgctt cagaaactga aacttaacct ttgcgtatcc
     3901 tacagaataa ataaatacac cgatactgtt tttggaaaag ccaaccattg gataagcttc
     3961 attatctttc catgcaaacg tagctccgcc tttattctga acaatcgatt ctgcagtgcg
     4021 cagatcataa cggggttctg cattctctac tcccacaaga atgagtctga catcaacaat
     4081 atttccatct ccatcttttc ctacattgtt ataacgcatc cctgcgcttc cggctttata
     4141 gtccgctcct acacgaacgc actctgtgtc acgttcgctt tttccattgt ctgaaaaagc
     4201 ttccctgtcc agattatcac acccaaaaga ttcatatgtg gtaattccgg gctgaaactt
     4261 catgttaaag cgataaccat aatctaccac cttgtcactg tcccatgttt ctacagttaa
     4321 cggtgccgcc tgagttacgc agacaggcac aagccccaga attgcctgca gaataaaaag
     4381 cattgcaagc agcaaagctc caaggcgttc tttcagtttg aaattgtgtt tcattttccg
     4441 tctcctttcc gaacaaaaaa tataaaaatg aatgtgggat ttttccctgc acctggcagg
     4501 attaaagaat agaaataagt tgagattgta tgattataaa tattcaaggg gaattaatat
     4561 cgtgaaacaa gaacgtttac acttaagatt tttaagattc tgcgcagggt ttcttttctg
     4621 aaaccctgca cagattttca ttgatcattt cttttcttca gccatgaaag aaaataaaga
     4681 ataattgcaa gaataataaa aaacggaatc gcaactccga ttatcagtat cagtaaaaca
     4741 attataacag ccgccgctgc aataacaaca gccctgccat gccaggtaga aagatcaatt
     4801 acttttttcc atcgtttctc ctgctgatga ggaaactctg tctcattgcc ataactgctt
     4861 ccgtaagaag aatactctcc gtaatcttcc tgtgtacttc catcatctgt atcaatcaga
     4921 gtctttgcta tcagatgtgg ggctcccagt tcctgcagta cttcctgctc tgaacgtccg
     4981 ccacgtacct gagactgtat ataatcttca taatacctga tatgtgccgc tgctttgccc
     5041 tcctgcatct gaccggcaag ctggcttctc aggatttcca aaaattcttt tctgttcatc
     5101 ttttacactc cattttgcca gaaatacatg tcaaaacttt cctgctccgt tatcagtaac
     5161 gttcgtactc ttattttacc atatatacta caggtagcaa ctaatataat cataaacttt
     5221 ttatgaaatt cttataaact cagttactgt tcactccgtt ctcagtaact gagccaaaat
     5281 tcattccaga ttgcctgcgg caatggaatt ttggcttgta tgtcatttcc cgacaatttt
     5341 tgcatacatc tccggtctgc ggtctctgaa aagtccccag ttcagtctgt ctgcctttaa
     5401 tgcatccagg tcaaaagtgc ttacaagcac cccctcttcc cctccgggca gttctgcaca
     5461 gagagcacct gtgttatctg taataaaaga ggaaccgtaa aaattaagag cagatttctg
     5521 cattccgttt tccggacatg gctctactgt ttcctcaccg attctgttgg cagcaatcac
     5581 aggaatcaga ttggaggcag cgtgtccctg catacatctt ctccagtgtt ccatgctgtc
     5641 acattccagg atgggttcac tgccgatggc agtgggataa aagagaagct ctgctccctg
     5701 cagtgccata catcttgccg tttccgggaa ccactgatcc cagcagattc caactccaat
     5761 ggttccaaat ctggtatcaa aaaccttaaa gccggtatct cccggtgtga aatagaattt
     5821 ttcctgataa taatggtcat ccggaatatg tgttttccgg taaacgccga gattcttccc
     5881 atctgcatcc agaaccgcaa cgctgttata ggtattattg acctcttttt cataaaaact
     5941 gaccgggatc acaatcccca gctctgccgc taccctgctg aaatgacgca ctgcagggtt
     6001 ttcctctgca gtctgcgcat attcataata ctcatatctg cgctcctggc agaaataggg
     6061 ccgttcaaaa agctccggaa gaagaacaat ctcagctccc tttgctgctg cctgacgcac
     6121 cagttcctct gcatgggcaa tatttttctc cacactttta ctgcatttca tctgaactgc
     6181 tgccactgtt acatttctca tcctgtctgt tcctcctgct cctgtttaca taagtaagtt
     6241 ttttcataac tttcaggtaa tacccctcaa acacatgact ctcaaagttt ttctgcatca
     6301 aggtcagata tttttccggg aatctgctgg gtaatacagt gaatatttcc accgccgaca
     6361 atgatggctc tggcatcaat gggataaatc cttcttttag gaaaacactt ctgcagaatc
     6421 tccactgccc ttttgtcatt ttcatcccca aactgtggaa ggatgattcc tccattggaa
     6481 atatagaaat tcacataact ggcagccatc cgttctcctg cttcccgttc gtcttctccc
     6541 tcttcaaaca caaagccatc cacatcttcc cgggtaaggc agaccggttt ctgaggaatc
     6601 ggaagcttat gaatcttaaa ttttctgcct tttgcatctg tttcctgttc cagcaccttc
     6661 agatcagcca aagacatggc atactgcgga tctgtctcat cctctgtcca tgcaagcaca
     6721 acctctccgg gccttacaaa agcgcacacg ttatccacat gctcattggt ttcatcctga
     6781 tagattccac atggaagcca gataatcttg tggacaccga gccagtactt caactgttcc
     6841 tctatctgtt ccctgctcat ctgaggattg cgtccctgac tcagaagaca ggcctctgta
     6901 acgatcagag tcccctctcc gtcagaatgg atggaaccgc cctcaagcac aaaaggtctg
     6961 gcatccagac atgggcaacc gagagtcctg cagataaagg cagccaccct gtcgtccttc
     7021 tcccagttcc ggtaaagccc gtcaaaggta cctccccagg cattaaactg ccagtcaact
     7081 ccacagactg cccctttctc atccagaacc atggttgctc ccacatctct ggcccaggcg
     7141 tcatctgtct cgcattccag taaagtcaca ccggaaacat tcccaagctg attctttgca
     7201 ttctccatct gggctttgga aaccagcata tatacctttt cgctctctcc aatagcctct
     7261 gcaactttca caaatgcttt ctgtgcttcc cttgctccat aattccagga accgggacgt
     7321 tccggccaga tcatcacaca tccctcatga ggctcaaatt ctccgggcat acgatatttt
     7381 gttctgttct tctctgtaac ttccatgtct gtctcctttt ctctgatagc caggcagata
     7441 tcaggaaagc cggctcttaa agtcttcgta cccgaaatgt ctgataacct cacactctcc
     7501 gtcctcatgc ataaccgcaa tatccggcag cggcataccg ttaaatgtat tattcttcac
     7561 catagaataa atcgccatat ccataaaata cagcttgtcc ccgatccgga tctctctgtc
     7621 aaaggaataa tctccgatca catctcctgc caggcaggtg caggaagata agcggtaggt
     7681 atatgccttc tcccctgctt ccccgctgtc cttaagaggc ggacgatagg gcatctccag
     7741 cacatccggc atatggcagg ctgcagaagc atccagaacc agcgttctga ttccattctc
     7801 cacaatatcc ataacctctg tcaccagata tccggcattc agggcaatag cctccccggg
     7861 ctccagataa atatccagat cataggtttc cttcatatgc cgaatacatt tttccagtcg
     7921 ctttacatca taatcctctc tggtaatatg atgtccgccg cccatattca gccaggaaac
     7981 ctcagacaga aattctccaa acttctcctc taccgcctgc aatgttttct ccaggtcatc
     8041 cgcattctgt tcacagagcg tatgaaaatg cagcccgtcg atccatttca gacattcccc
     8101 gtcaaagttc tctctggtaa cccccagcct tgaacccggc gcacagggat catagatcgc
     8161 atgatccccc tgagtggagc attccggatt aatacggagt cccagactgg ctccggtaca
     8221 cacttcttta aatttcttca gctgtgctgt ggaattaaag ataatatggt cacagatccg
     8281 gtccagttcc gccatatctt ctgtgcggta agcaggggaa aaaacatgat tctctttccc
     8341 catctcttca tatccaagcc ttgcctcaaa cagaccgctg gcagtggtac ctgccagata
     8401 ttttccgatc atgggataca gggcaaagcc ggaaaacgct ttctgcgcca gaaggatctt
     8461 acacccggta tcctcctgga cttttttcaa aatctccaga ttctcccgca tcttcttctc
     8521 atcgatcaca taacagggag tttgcagttg atcaatcttc attggctttc cagaccttta
     8581 ccagttcagg atcttcgcag actttccatg gaagtcccca tttgttcagt gcttccatat
     8641 atggatccgg atcaaattct tccacattaa atacacccgg cttcttccac tgtccggtca
     8701 ctaccatcat ggaaccgatc atagccggaa cacctgttgt ataggagatt gcctgggatt
     8761 ccacctcttt atagcattcc tgatgatcac atacattata aatataaata cttttctctt
     8821 ttccgtcctt aacacctgtg aaaatacagc cgatatttgt tttacccact gttctcggac
     8881 ccagagatgc aggatccggt agaagagctt tcaaaaactg gatcggcacg atctcctgtc
     8941 cattaaattc cacaggtgcg gtggaaagca ttcctacatt ttccagacat ttcatatgtg
     9001 tcagatagct ctgtccgaat gtcataaaga aacggatcct ctgtactccc ggaatatttt
     9061 ttgccagtga ttcaatctct tcatgatgaa gaagatacat atccttcttt cctacctcag
     9121 ggaaatcgta gacagattta aattccatag gctctgtttc tacccaatgt ccgtcttccc
     9181 agtaggaacc atttgcggaa acctctcgaa gattgatctc cgggttaaag tttgtggcaa
     9241 aaggatatcc atgatcaccg ccgttacagt ccagaatatc aatggtatgg atttcatcaa
     9301 aataatgctt cagggcataa gcactgaata cactggtaac ccccgggtca aaaccggttc
     9361 ccagaagagc ggtcagtcct gcttccttaa atttctcatc ataagcccac tgccaggaat
     9421 aatcgaaata tgcagtaaag cctttttctt tacatctctt ttcgtagatt gcacgccatg
     9481 tgggatcttc tgtatcctct gcttcataat tggcagtatc aatataatcc gcaccggctt
     9541 ccagacatgc atccatgatg gtaagatcct gatatggaag tgccacattc aggacagcat
     9601 ccggcttata ggctctgatc aattctgcga cctctgctgc attatccgca tctacctttg
     9661 ctgtctcaat ttttgtcttc gttgtacttt caatcttctc tttgagtgca tcgcattttt
     9721 cctttgtcct gcttgcaatc ataatctctg taaaaacatc gctattctga cagcatttgc
     9781 gaattgccac tgaagctacc ccaccacatc caattaccaa taatctgctc ataaactgtt
     9841 ttcctcctct tccagtaaat cttctacata ttttggaagc ataaatgctc ctctgtgaag
     9901 gtttgttgta taataccatg tttctatatt aagattatca aacctctccg gcctgaaatc
     9961 ttccagtgga tgatatttct ttgatgcaaa tccaaaaagc cagtatcccg agggacaggt
    10021 agggatatgt gcctgataaa ccctgctcac cggaaatgac cggaaaacct ttctgtgcat
    10081 ctttctgcat tccacctcat cctcatcata aaaaggactt ccatgctgat aaaccatgat
    10141 tccgtcatct ctgagagcct tataacagct tccgtagaat tcctttgtaa aaagtccctc
    10201 tgtatgtccc agcggatctg tggaatcatt gatgatcagg tcatatctgg cctttttatt
    10261 ccgcaggaac cgaaggccgt cttcataata aatgttgact ctctcatcct tcagtccctg
    10321 ggcaatatcc ggaaacatct ccgcacatac atccacaaac attttatcgg attccaccac
    10381 atcaatgctc tcaatctgtg gataatggat cagttctctg gcaactccac cgtcaccgcc
    10441 gccgatgatc agaacatttt ttacattggg atgtactgtc attggcacat gcgtgaccat
    10501 ttcatcataa ataaattcat ccttgtcaga aaatacgatc tcaccgtcca gagccacaaa
    10561 tcttccaaat tcttcagact caaacacatc gattctctga aattcacttt cccctgaaaa
    10621 taactgtcgg ttaatccgga cagaaagctt tacatttcct gtatggaact cggaatacca
    10681 taattccatg atcagatacc ccctttcagg acctgaagat gttctacctt cggatcctcc
    10741 attccctgca tggaacagcc tttgtctctt gcataaagaa tgtattctac aatttcctgt
    10801 gtcaccattt ctccaggagc aagaatcggg attcccggag gataacacat aacaaattca
    10861 ccgctgatcc tgcctgccgc ctgttccatg ggcagagatt ctttctccgc ataaaatgcc
    10921 tgctgtggag acgccaccac tgcaggtgcg atatattccc cggaaagcat acctgtgctg
    10981 tccttcttat acagacgttc aatatcagcc aatgccccta ccagtctctc aatatcctga
    11041 agcctgtctc cgatggaaat gtaagccaga atattacaga tatctccaaa ctcgatctga
    11101 atatcatatt catctctgag aagatcataa acttcaatac ctgccaaccc atttcccagt
    11161 gtataaatgg agagttttgt aacatcaaaa tcaaaaacac tggttccgtt gatcagatcc
    11221 ataccatatg cataataacc gccgatctca ttgatctcct ctctggcata ctgcgccatc
    11281 cctgcaacct tttcaaagga ttcctctccc ctgagtgcca gatttcttct ggagatatcc
    11341 agactggaca acagaagata agaagcgctt gtggtctgag tcagattgat gatctggcgc
    11401 actttctctg cattcatact cttattcaaa agcagcagcg aactctgtgt cagacttccg
    11461 ccggatttgt gcatggaaac tgccgccatg tcagcacctg ccgccattcc ggacacagga
    11521 aggtttctgc caaaataaag atgggttcca tgagcctcat ctgccaacac cttcattcct
    11581 cttgcatgag ccttctttac gatagtccgc agatccgaac agattccata ataggtaggg
    11641 ttatttacaa gaaccgccac cgcatccgga ttctcatcca tagccttctc cacctggctg
    11701 acttccatgc caagggaaat gcccagctgc gcattcacct ccggatttac ataaaccgga
    11761 attgcaccgc acagtaccag ggcattgatg gcacttttat gtacatttcg cggcagaatg
    11821 atcttatccc ctgccttgca gacagacagg atcatgctct gcactgcaga tgtggttcct
    11881 cctaccataa ggaatgcatg cgctgcgcca aaagcatctg ctgcaagctc ctccgcttct
    11941 ctgatcaccg aaaccgggtg gcagagattg tccagcggct tcatagaatt aacatccagc
    12001 cccacacatt tctctcccag cagctgtgca agctccggat ttcctcttcc tcttttatgt
    12061 cccggcacat caaagggaac gactctcttc tttcggaaac gttccagtgc ttcatatatg
    12121 ggcgcatgct gttgtctttc ataatccatt tgacatgttc ctcttttcct gtcgtcatgt
    12181 accggcaaat acagttctat cattcagcaa ttgtatactg cctcaaaccg gcacaatgat
    12241 tcaattattt ctctatatat tcaagtcgaa cgcatgtgag acacatcctc gcaaagcgtt
    12301 tatctccaac catatccttt atatttgcta tatctgcaca aaaaagaagc agataagttc
    12361 attcaccatc tgcttctctc atgatctata gaatttctca ggctctgtct ctttatatac
    12421 tgaccggatt tcccgtataa atccgtctgt atcctgtgcc tgttcctgta ttctgaaata
    12481 ttcatgactg ctgtcgtctt caatcgctgg caaatatatg ctatgctctt attgaccgtt
    12541 tcacaagatg atgtgtgctt acgcactgat tattataaag taatcaactt ataaaatttg
    12601 agctcctaac tcaatcaata atgtggtgtc tcccacccgg caactgcccc gcctgtccgt
    12661 atggcttaac attcagaaac tgtctctgaa tgtgagcaaa tatttgcatg aaaacgatag
    12721 tgtcttttca tactaaagat gagaataaca tatcttctga actgttgtca attccatttt
    12781 ccatattttg cacagtcttt acccgctttt tatattttct tcatttgtca gggaaaactg
    12841 tgtttatttt ttaacaattt cttcccttga gaaaacgtat tttctttcat taccaaggat
    12901 tacgattctc ttctcttatc aatttgcaca acttttatcc agtttactca c
//
