LOCUS       gnlProkkaMKIECKOO_1    12669 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MKIECKOO_1.
ACCESSION   gnlProkkaMKIECKOO_1
VERSION     gnlProkkaMKIECKOO_1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 07:55:47
            Original ID  :: gnl|Prokka|MKIECKOO_1
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12669
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12669
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2:2669]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3..2669
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..12669
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12669
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     CDS             3..2669
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     754.3; E-value: 3.4e-228)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1"
                     /sec_met_domain="DUF4135 (E-value: 5.8e-92, bitscore:
                     301.7, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.5e-52, bitscore:
                     169.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLINIIQRIVIFDIYRKKTNHDLRGNNVKEQYDYYEKKYLNNAT
                     YVKSLLQEYPELKRLLELKNNSTQRAECEIGKSLYAEKEQIQKIFCDGRKFSGTVGIYM
                     AKGDIHRGGRSVAKVELDNGTILYYKPHSLDKNIKYQELYNYLCRKTGISCRTVQYLSH
                     DSYGWEEKIENIPCKNESEVEHYYFRMGIHLFLGYALGATDLHGENIIAHGEYPVIIDM
                     ETYPGYLKQQSEKDGSSVEEKINKSTEIKLANSVIHTGMLPVLTWGRGNSRVLISAMGT
                     EEKIKTPFKLPVVKDDKTSDIHIEYEPVEMQIKECIVRLNDQVINAADYTECIIRGFCR
                     AYMVTMADKKVEVMLSGFFDGRSRVVLRHTQQYAMYLMASFHPDYMKSRECRKALLNVI
                     HKEGESSFMKEIHDYEIDSLLEMDIPCFEIDANSRSVYDGNGGEHKEYLPCTPYESWRM
                     HMKQMSYSDMECQCDYIRLSMEMLKASDGKKKMFPTRIKGYDTDKERKIYSQIRKIVHR
                     ICSRAIIREQSAGWAGLQFWDNGHWNLRSGGIYLYDGISGIVLFLAKYLHDFEEKNASA
                     EEIYHLAVLRLKAYTDEIHKKQIYDKNLLTGIVNGESSVVYTYLYLFKLTGKRVWMIYA
                     EKHFSIIERVWKEDSQLDYLSGNAGAIVMAVMLYKETGNLKYYEIAADMEKDLWKKGQE
                     TGNGYGWRLKGTDGPLAGMSHGNSGFMMAYAALYECNHKAEYADKIQLLLRYEDSLYSE
                     KAGNWKDLRESSGESFMNAWCHGAPGILLSRMKLEELFPEDMQIKKDRLNAADSLFYGE
                     QDEKICLCHGMSGNLLIMKKYLRKYGNKKMKEQYEALCDCLLFQLDHPAKISGTEYLNL
                     AFMNGISGTGMALMEIL"
     CDS             complement(2722..3246)
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MKTLTELIQNYQNGIPDSDSEILKRMEPLVKGYASRIHCMEREDS
                     TQELYLTLLKTLPYLSSSSSEGECIRYMQTSVENRYRSLCRSCLSEPEKDDFDSCSVSL
                     QAPDSFDDTYYDVTAYINSYPSDSVQRKILSMYFYQDKSDAQIARKLKLSRQYVNRMKK
                     KLILKYISENK"
     CDS             3547..3786
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="METTVMNVAVSHGIWAVLAVFLLVYIVKSNEKRDEKQEEREKNYQ
                     SVIEKLTEKLEILHQVQSDLSEIKEKLFDKHKQE"
     CDS             3973..5550
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MDRKKFIAVAISAALGLSGAPVYASESVTFSDGEVQEYGAEEEKQ
                     EFQTDSQDPETDAFQDKMESDADTDGFLDEATGVSSGEADANGFTYQYLKESDTYRLTK
                     GTDTENVIIPYEYNGKVVSEVGERAFYGCINIKTVKAEEGADRRKNHIRIDKSAFENCE
                     NLRKVSFDQGAKLESRAFYNCPKLWEYTGVSYYDSFDTEIEQDSFDADTKVIFRAGDNG
                     IPESVKAFADKNRVFMEITDNDDYVLTDKDGTSYYDDWSEGDSRTFCVDCDDTMASVRV
                     WSAVEVIGRKAFYGCSNVKKVLIERKTSTIESKAFAKCKNMSIIMPSGITAISDDAFDG
                     ASGITIYADKGSYAEKYAKKHNLTCKTIPAPTAVPVPKLKVSYDEKNGNATLNWTPVEY
                     TFQYYIYRYDTATKKYKCVSKVDQNTTSYKPENPVGRTVKYKVRVRTLAGIYTDQYSKR
                     SNTVTVQGRPGNVSDISKKKKGKNLTFKWTKAKGAQGYILYRYDENARKYRKIKTIKNS
                     RIFLSAAR"
     CDS             complement(5736..7040)
                     /gene_functions="other (smcogs) SMCOG1077:phage integrase
                     family protein (Score: 124.6; E-value: 1.2e-37)"
                     /gene_kind="other"
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MAISTRQVKNKRDSNGVLTGRPGTVYDVNIKYTAPNGEKKTYSKK
                     GFPTKKEATQHEAEMKAKLHNPGQIASIASQRKQTVASYLNEWVESYARVNLRPSTYDG
                     YKKTIANYINPYIGGVALNQLTPAMVDKMFQQIIDKGLKPSTAAGAKRVLSVALSHARK
                     YRYIETNAAKDTLTKFGKSDKTPDPYTPEQVKALMQRVEGTVWEMPVILGGLYGMRRSE
                     ILGLRWRNVDLENNTFDVSEQLPFKVPPKTKVIEEMAPPKSNGRKLPITELARPFFLKQ
                     FAMQEAQREQAEKDGKPYYDNDLVVAKPDGSPISASWVSSQFGKLLEDLDMPHIRFHDL
                     RHTAATNMHQLTGDFYTVGEVLGHTLAGIGVSLGLSMNFEAVTARYVDVRLERKKEVLD
                     AYHGAVKQADPAKAEKAEPKKAKSAAKKKSSDLEL"
     CDS             complement(7044..7280)
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MAKKETTSPAIPVFPMLKTVEQMSKISGIGENKLRELMDSGELEY
                     IQNGNRRLIADAAIWDWYHRAKTTAKPPARQGG"
     CDS             complement(7307..7405)
                     /gene="allorf_007307_007405"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_007307_007405"
                     /protein_id="allorf_007307_007405"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGKAALNEQGCNSREVVLTAARLKPTFCNLTF"
     CDS_motif       complement(7346..7405)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MGKAALNEQGCNSREVVLTA"
                     /locus_tag="allorf_007307_007405_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7307..7345)
                     /prepeptide="core"
                     /locus_tag="allorf_007307_007405_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.50"
                     /molecular_weight="1374.6"
                     /monoisotopic_mass="1373.7"
                     /core_sequence="ARLKPTFCNLTF"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGKAALNEQGCNSREVVLTA"
                     /leader_location="[7345:7405](-)"
                     /alternative_weights="1392.7"
     CDS             7545..7664
                     /gene="allorf_007545_007664"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_007545_007664"
                     /protein_id="allorf_007545_007664"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MAHPLYGSAQKGRTRFALYCVAVILRRFLCQGTYGAAAD"
     CDS_motif       7545..7568
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MAHPLYGS"
                     /locus_tag="allorf_007545_007664_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       7569..7664
                     /prepeptide="core"
                     /locus_tag="allorf_007545_007664_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.50"
                     /molecular_weight="3383.9"
                     /monoisotopic_mass="3381.8"
                     /core_sequence="AQKGRTRFALYCVAVILRRFLCQGTYGAAAD"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAHPLYGS"
                     /leader_location="[7544:7568](+)"
     CDS             7561..7686
                     /gene="allorf_007561_007686"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_007561_007686"
                     /protein_id="allorf_007561_007686"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MARRKKDVPGLPYTASPLSCVAFFVKEHTGLLRIDTKRKRG"
     CDS_motif       7561..7593
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MARRKKDVPGL"
                     /locus_tag="allorf_007561_007686_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       7594..7686
                     /prepeptide="core"
                     /locus_tag="allorf_007561_007686_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.20"
                     /molecular_weight="3301.8"
                     /monoisotopic_mass="3299.8"
                     /core_sequence="PYTASPLSCVAFFVKEHTGLLRIDTKRKRG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MARRKKDVPGL"
                     /leader_location="[7560:7593](+)"
                     /alternative_weights="3319.9"
                     /alternative_weights="3337.9"
                     /alternative_weights="3355.9"
                     /alternative_weights="3373.9"
     CDS             complement(7708..7965)
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MNGTNGKQSDFPDVALVPYPVIVAATKGDPDAMKIVLQHFSGYIA
                     SLSMRKLCDERGNVYFGVDEDIRQRLQARLMRAILTFRAE"
     CDS             complement(7946..8386)
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MEPNRVEFQKQCIFQSYCKRVLHNEACNAHEEIRRRRAKEVSFSD
                     LALHEERQLYTLDKYFQDEEAEPSYQQAGKKITPKLLLEAIRTLPEEKRKAIMLYYFEG
                     MTDVEIGKLFNTSRSTIQYRRTSSFEILKKYLEEHADEWDEW"
     CDS             complement(8562..8687)
                     /gene="allorf_008562_008687"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_008562_008687"
                     /protein_id="allorf_008562_008687"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MEVAAMIYRAYRQSTAHFSLSKKARPPPGTLLPSYMNCQII"
     CDS_motif       complement(8631..8687)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MEVAAMIYRAYRQSTAHFS"
                     /locus_tag="allorf_008562_008687_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8562..8630)
                     /prepeptide="core"
                     /locus_tag="allorf_008562_008687_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.40"
                     /molecular_weight="2373.9"
                     /monoisotopic_mass="2372.3"
                     /core_sequence="LSKKARPPPGTLLPSYMNCQII"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEVAAMIYRAYRQSTAHFS"
                     /leader_location="[8630:8687](-)"
                     /alternative_weights="2391.9"
                     /alternative_weights="2409.9"
     CDS             complement(8845..9759)
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MGWAIMFLVLIALVIILSISLINWKIQIYKVIVQLNAILNRKTKK
                     LVTVSLSDRRLEHLVEIINQIVSKDNIYLGEIQKKENELKENISCLSHDLRTPLTSIRG
                     YLQLLSSAPDEKRAEYISALSGKALRLERLIDDFYQISLLEAGQYPFYYEKVELCSLLT
                     EILLDNYSIFSVNGIEPQIEIPNMDIYLNADRKACIRIIQNLIFNAVTSTTNNVVIQLI
                     NIADSVQLCIKNPVASIPTEEYSKLLERFYVADVSRSNGTSGQGLYIVKKLLLMMNCTN
                     PIIEIHDHNFMITIDFSPLLIKK"
     CDS             complement(9774..10580)
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MINHFKAEFYKLRHSKILITILGVCAAVIMVSFALGDMTFFGAGD
                     GTESVIGFQAKCYLSSEIPTFQTVARSSLAYTAFFWIIGILFATIFFTKEYNTGTIKLS
                     VAYGTKRTILYYTKAITILVVSLITYLIFVATFFVIEIIQSGYIPTASEVINLLGWALA
                     CGTVLLALESISIFLCVVIQNTGIVTGICCLYVFSGASVYLMLWSDMETVSIPLKFFVY
                     GNPMYYWMNFSSCRTMGIIEHLPFYFIGCISLLIVGGLIMIRKEIK"
     CDS             complement(10573..11493)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 170.2; E-value:
                     9.4e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MNVTVFEAINITKKYRNTLALNQVSMSVMQGDIYGFIGENGAGKT
                     TMIRLLTGLAEPTTGKIALFGESNKKLAKQRERIGCIIESPSLYLDMTAYENLEVQRLQ
                     RGIPGKGCIDNALALVGLKDTGKKKAKDFSLGMRQRLALAIALLGNPEFLVLDEPINGL
                     DPTGIIELRNLLKRLNKERGITILISSHILTELHQLANRYGILHEGKLLQEITATGLDK
                     RCKKHLLLQVNDVAAASVLLESKLNTSNFSVMPDKSIHLYDYVENAGKVSALLSANNIT
                     IYQLAQSGDSLETYYTNLIGGCQND"
     CDS             complement(11578..12243)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 181.8; E-value: 2.3e-55)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MNNVLIIEDDKEICVMIKDHLEKYNYQVFFTLTGANAIERIKELS
                     PDLIILDLMLPFISGDELIRNIRKFSDVPVIVVSAKSLTFNKVELLRLGADDYLTKPFD
                     LDELLARIERNLLRSQKDTPNLCLTFGELSINTSSKIVTVADEIIVLTAKEYQLVELLA
                     KYPDKVFSKQNLYESIWQEPFARDNDVINTHISNLRKKLKGEGCRIKTIWGLGYRFAK"
     CDS             complement(12236..12415)
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MEYMSCAEAAGKWGISERRVQKLCEGERIPGVSKFGSMWLIPKDV
                     EKPTDRRRKEFQHE"
ORIGIN
        1 atattaaatt gataaacatt attcaacgaa tagtaatatt tgatatatat cgaaaaaaaa
       61 ccaaccatga tcttcggggt aataacgtaa aagaacaata tgattattat gaaaaaaaat
      121 atcttaacaa tgcaacatat gtaaaatctt tactgcagga atatcccgag ttaaaacgtc
      181 tgcttgaatt aaaaaataac tctacccaga gggcagaatg tgaaatcggg aaatcccttt
      241 atgcagaaaa agaacagata caaaaaatat tctgtgatgg aaggaagttt tccgggactg
      301 tgggaattta catggcgaaa ggcgatatac acagaggagg acgaagtgtg gcgaaggtag
      361 aattggataa tggaacaatt ctgtactata agccacatag tcttgataag aatataaaat
      421 atcaggaact ttataactat ttatgcagaa aaacaggaat ttcctgcagg acggtacaat
      481 atttatctca tgattcctat ggatgggaag aaaaaattga gaatattccc tgtaaaaacg
      541 aaagtgaggt ggagcattat tatttcagaa tgggcataca tctgtttttg ggatatgccc
      601 ttggagcaac agatcttcat ggtgaaaata ttatcgcaca tggagaatat cctgtgatta
      661 tcgatatgga aacgtatccg ggatatttaa aacaacaatc agaaaaagac ggaagtagtg
      721 tagaagaaaa aataaacaaa agtacagaaa taaaattggc aaattcggtt atacatacag
      781 gaatgctccc tgttctcaca tggggcagag gaaacagcag agttcttata agtgcaatgg
      841 gaacagagga aaagataaaa acgccgttta aacttcctgt ggtaaaggat gataaaacat
      901 ctgatattca catagaatat gaacctgtgg aaatgcagat aaaggaatgc attgtaagac
      961 taaatgatca ggttatcaat gcggcagatt atacggaatg cattatcaga ggattttgca
     1021 gagcgtacat ggtgacaatg gcagataaga aagtggaggt gatgttgtcc ggcttttttg
     1081 acggacgttc cagagttgta ctgcggcata cccaacagta tgcaatgtat cttatggctt
     1141 cgtttcatcc ggattatatg aagtcaagag aatgcaggaa agctcttttg aatgtgattc
     1201 acaaagaggg ggaatcttct tttatgaaag agattcatga ttatgaaatt gacagccttc
     1261 tggaaatgga tataccctgc tttgagattg atgcgaacag cagatctgtt tatgatggaa
     1321 atggcggaga acataaagaa tatctgccct gtactcctta tgagtcatgg cgaatgcata
     1381 tgaagcagat gagttactct gatatggaat gtcagtgtga ttatatcagg ctgtccatgg
     1441 aaatgctgaa ggcatctgat ggaaagaaaa agatgtttcc gaccaggata aagggatatg
     1501 acacagataa agagcgcaaa atatacagtc agatcagaaa gatagttcat cgaatctgca
     1561 gcagagcaat tatccgggaa cagagcgccg gctgggcggg tctgcaattc tgggataatg
     1621 gtcactggaa tctcagatca ggtggaatat atttatatga tggaatatcc gggatagtct
     1681 tgtttcttgc aaaatatctt catgattttg aagaaaagaa tgcaagtgca gaagaaattt
     1741 atcatcttgc tgttttgaga ttgaaagctt atacagatga aatacacaaa aaacagattt
     1801 atgataaaaa tcttctgaca ggtattgtaa atggagaaag ctcggtggta tatacctatc
     1861 tttatttgtt taaacttaca ggaaaaagag tatggatgat ttatgcggaa aagcatttca
     1921 gcattattga gagggtatgg aaagaagatt cacaactgga ttatctgagc ggaaatgccg
     1981 gagctattgt aatggcagta atgttatata aagaaaccgg aaatctgaaa tattatgaaa
     2041 tagcggcaga tatggaaaaa gatttgtgga agaaaggaca ggaaaccgga aatggatacg
     2101 gatggagatt aaaaggaaca gacggaccgc tggctggaat gtctcatggc aacagtggat
     2161 ttatgatggc ttatgcagcg ttgtatgaat gtaatcataa agcggaatat gctgataaaa
     2221 tacagctttt gctgagatat gaggattctc tgtactcaga gaaagccgga aactggaagg
     2281 atttacgaga gagttcaggg gaaagcttca tgaatgcatg gtgccatggg gcgccgggaa
     2341 tcctgctttc acgaatgaaa ctggaagagc tgtttcctga ggatatgcag attaaaaaag
     2401 acaggttaaa tgctgcagac tctttgtttt atggagaaca ggatgaaaaa atttgtctgt
     2461 gtcatgggat gtccgggaat ttacttatta tgaagaagta tcttcgaaaa tatggtaata
     2521 aaaaaatgaa ggagcaatat gaggcgttat gtgactgcct tttatttcaa ctggatcacc
     2581 cggcaaaaat atctgggaca gaatatctga atctggcttt tatgaatggc atttccggta
     2641 cgggaatggc attaatggaa attttatgaa aactaaggga acacctgcag actgtaaatt
     2701 tatggtcagc aggtgtttct tttatttgtt ttcggaaata tatttgagaa ttagtttctt
     2761 cttcatccga ttgacgtact ggcgggacag cttcagtttc cgggcaatct gggcatcgct
     2821 tttatcctga taaaagtaca tggacagaat ttttctctgg acactgtccg aagggtaaga
     2881 gttgatatat gcggtcacat cataataggt gtcatcaaaa ctgtcgggag cctgtaatga
     2941 aacagaacaa gaatcaaaat catctttttc aggttcggaa agacaactgc ggcaaaggga
     3001 acgatatctg ttttcgacag aggtctgcat gtatctgata cattcacctt ctgaggatga
     3061 agaacttaaa tatggcaatg tctttaacag agtaagatac aattcctgtg tggaatcttc
     3121 acgttccatg cagtgaatcc gggatgcata tcctttcaca agcggttcca tacgtttgag
     3181 aatttcactg tctgaatctg ggataccatt ttgataattt tggataagtt ctgtcagtgt
     3241 tttcatagtt atctacctcc tttttagggg aagtagtaag aaaactgctg atcagaaact
     3301 aaaaaagaaa aaaattgtga gtttacaaat ggaagagaaa aaactcttta ttaagtgagt
     3361 ttgcaaattc aaattaatga taagaggaga aaaaatatat ggtaaaaaga gattggtaga
     3421 ataattgtag agaataaaac tgtgccttaa attggaacgg taataataag accagaaaag
     3481 acttttagtg gatggaatat agaaaaaatg cgtaataaaa gaagattaag aggagggagg
     3541 tgaactatgg aaacaacggt tatgaatgtg gcagtttcgc atggaatctg ggcagtgctg
     3601 gcggtatttc ttttggttta tattgtgaaa tcaaatgaaa aacgagatga gaaacaggaa
     3661 gagcgggaaa aaaattatca gtctgtaata gagaaactga cagagaaatt agagatttta
     3721 catcaggtac aaagtgattt atcagaaatc aaagagaagc tttttgataa gcataagcag
     3781 gagtaaaata acacttggtg cagaggttaa aagcttatca agaaatacaa atttgcagag
     3841 ttcacaacta acgtttgtat aatataagat tcatgtccat caaaatacat ttaatgccat
     3901 aattacaaaa atttctccat cttgttatat attaacacta acggttaaat atcacggaat
     3961 ggaggaattt ttatggatag aaaaaagttc atagcggttg ctatttcggc agcacttggt
     4021 ttatccggtg ctccggttta tgcatcagaa tctgtaacat tttctgatgg ggaagtacag
     4081 gaatatggag cagaagaaga gaaacaggaa ttccagacag atagccagga tcctgaaact
     4141 gatgcatttc aggataaaat ggaatcagat gcagatacag acggattttt ggatgaagca
     4201 acaggagtat cctcagggga agcggatgcg aatggattta catatcaata tcttaaagaa
     4261 tctgatacat accgcctgac aaagggaaca gatacagaga atgtcataat accttatgag
     4321 tataatggaa aagtagtttc agaggttgga gagagagctt tttacggatg tataaacata
     4381 aaaactgtga aagcagaaga gggagctgac agaaggaaaa atcatatccg cattgataaa
     4441 tctgcttttg agaactgtga aaatctcaga aaagtttctt ttgatcaggg agcgaagctg
     4501 gaaagcaggg cattttataa ttgtccgaag ctgtgggagt atacaggtgt ttcctactat
     4561 gattcttttg acacagaaat agaacaggat tcttttgacg cggatacaaa ggtaatattc
     4621 agagcaggag ataatggaat tccggagtct gttaaggctt ttgcagacaa gaacagggta
     4681 tttatggaaa ttacggataa tgatgattat gttctgacag ataaagatgg tacttcttat
     4741 tatgatgact ggagtgaagg agattccaga acattctgtg tagattgtga tgatacaatg
     4801 gcatcggtaa gagtgtggtc tgctgtggaa gtgattgggc ggaaagcttt ttatggatgc
     4861 tcaaatgtaa aaaaagtgct cattgagagg aaaacttcaa cgattgagtc gaaagctttt
     4921 gcaaagtgca aaaatatgag tattattatg ccttccggta taacagcaat cagtgacgat
     4981 gcttttgatg gtgcttctgg cattactatt tacgcggata agggctctta tgcggaaaaa
     5041 tatgcaaaga aacataatct gacctgcaag acaataccag caccgacagc agtaccggta
     5101 ccgaaactga aggtatctta tgatgaaaaa aatggtaatg ctacattaaa ctggacaccg
     5161 gtagaatata cttttcaata ttatatttac agatatgata cagccacaaa aaaatataaa
     5221 tgtgtaagta aagttgacca gaatactacg tcatataagc ctgagaaccc tgtagggaga
     5281 acagtgaaat acaaagtccg ggtaagaaca ttagccggaa tatatacaga ccagtacagt
     5341 aagaggagta atacagtgac tgtccaggga cgaccgggga atgtaagtga tatttctaaa
     5401 aagaagaagg ggaaaaacct tacgtttaag tggacaaagg caaaaggcgc acagggatat
     5461 attctgtaca gatatgatga aaatgcccgg aagtacagaa aaatcaaaac tataaaaaat
     5521 agtagaattt ttctctctgc cgcaagatga ttttaggtcg gttgagggat tagaaaacgc
     5581 cggaaacccg cataaactct atgtttttgc gggttctcgg cgtttctttt atcgcctgta
     5641 ttagtggtgc tttttcggta aatggtgccc aaatggtgcc caaatcccac gcggggctat
     5701 aaaacgatat aagaagcggt aaagagatac agcggttaaa gctctaaatc gctgctcttt
     5761 ttctttgccg cgctctttgc tttcttcggc tcggctttct ctgcctttgc cgggtcagcc
     5821 tgtttgaccg ccccatgata agcgtctaag acttctttct tgcgttcaag ccgcacgtcc
     5881 acataacggg cggtaacagc ttcaaagttc atagacagtc caagcgatac gccgataccc
     5941 gcaagcgtat gtcctaacac ttcgcctacg gtgtagaagt cgcctgtcag ttggtgcata
     6001 ttcgtagccg ccgtatggcg taaatcgtga aagcggatat gcggcatatc caaatcttca
     6061 agcagttttc caaactggga agatacccac gacgcggaga taggggaacc gtccggcttc
     6121 gctacaacaa ggtcattgtc atagtatggc tttccgtctt tttctgcctg ttcgcgctgc
     6181 gcttcctgca tagcaaactg tttgaggaag aacgggcggg caagctctgt gataggcagc
     6241 tttcgcccgt tggatttcgg cggtgccatt tcctcaatga cttttgtttt cggcggcacc
     6301 ttaaagggta gctgctcgga aacgtcaaag gtgttgtttt ccaaatccac attacgccag
     6361 cgcaagccca ggatttcaga acggcgcata ccgtaaagcc cacctaagat aacgggcatt
     6421 tcccaaacgg taccctcgac gcgctgcata agggctttta cctgttccgg cgtataaggg
     6481 tcgggggtct tgtcgctctt tccaaacttc gtaagcgtgt cctttgctgc gtttgtttcg
     6541 atatagcggt atttccgggc atggctcaac gccacgctca aaacacgctt tgccccggct
     6601 gcggtggacg gtttcaagcc tttgtcaata atctgctgaa acattttgtc taccatagcg
     6661 ggggtaagct gattaagggc aacgccgccg atatagggat tgatatagtt tgcaatcgtc
     6721 tttttgtacc cgtcgtaagt agaggggcgc aagttcactc ttgcatagct ttccacccat
     6781 tcattcagat agcttgcaac ggtctgtttc cgctgtgaag cgatagacgc aatctgcccc
     6841 ggattatgga gctttgcttt catctctgct tcatgctgcg ttgcttcctt ttttgtcgga
     6901 aagccctttt tggaataggt tttcttttcc ccattcgggg cggtgtactt gatattcacg
     6961 tcgtaaactg ttcccggtcg cccggtcagt acgccgttgc tgtcgcgttt attcttaacc
     7021 tgccttgttg atatagccat agcttaacct ccctgtcgtg ctgggggctt cgctgtcgtc
     7081 tttgccctgt gataccagtc ccagattgca gcgtcagcta tcaaacggcg gtttccattc
     7141 tgtatatatt caagctcgcc gctatccata agctcgcgca gcttattttc cccgataccg
     7201 ctaatcttgc tcatttgctc aacggtcttt aacataggga atacagggat agcggggctt
     7261 gttgtttcct tttttgccat aggaaaatac cccctttcat aaatggctaa aaagtcaagt
     7321 tacaaaaagt gggctttaac cgggcggctg ttagcacaac ctcgcgggaa ttgcacccct
     7381 gctcatttaa ggcagcttta cccattgcct gcgacgctct gaacgctcgg actgtggatg
     7441 taaaggctta tcttccctca atgcgtgtcg tcgcccgcaa gctgctaact tgcttcccgt
     7501 cgcggtgttt ttcgctcggc ttttcccgat aaggaaatag cgtcatggcg caccctctgt
     7561 atggctcggc gcaaaaagga cgtacccggt ttgccctata ctgcgtcgcc gttatcttgc
     7621 gtcgctttct ttgtcaagga acatacgggg ctgctgcgga ttgatacgaa acggaaaagg
     7681 ggttaagacg tttcggtatc ggtgcagtta ttcagcccta aatgtgagga ttgccctcat
     7741 tagccttgct tgcagccgtt ggcgaatatc ctcgtcaacg ccaaaataga cgtttccgcg
     7801 ctcatcgcag agctttctca tagaaaggct cgctatgtaa ccgctaaaat gctgcaagac
     7861 aattttcata gcgtccgggt cgccctttgt cgctgccaca atgacaggat agggaacaag
     7921 ggcaacgtcc gggaagtcag attgtttacc attcgtccca ttcatcagcg tgttcctcca
     7981 aatatttctt caagatttca aaagagcttg tccgtctgta ctgtatcgtg ctgcgcgacg
     8041 tattgaataa ctttccaatc tccacgtcgg tcatgccctc gaaatagtac agcatgatag
     8101 ctttcctttt ttcttccggc aaagtgcgga ttgcttcaag caacagcttc ggcgtgattt
     8161 tctttcccgc ctgctgatag ctcggctcgg cttcttcgtc ttgaaaatac ttgtcaagcg
     8221 tgtaaagctg ccgctcctca tgcaaggcaa ggtcggaaaa cgacacttcc tttgctctgc
     8281 gacgccggat ttcctcatgg gcgttgcagg cttcgttatg cagcacccgt ttgcagtaac
     8341 tttgaaagat acattgcttc tgaaattcca cgcgattagg ttccatgttc tcacctcctt
     8401 tcgtgttgaa aggtggcggt acctcccctt ttcgcgggat aatacaggtg attttttcaa
     8461 acgccgaatg aaagcgaaac ttttttgaaa aaacctcccg aaaatgcaaa atgcgcccat
     8521 ctgcaagacg cagacaggcg caagggaatt ataaaaagta tttagatgat ttgacagttc
     8581 atatatgagg gtagaagtgt ccccggcggt ggacgagctt tttttgataa gctgaaatgt
     8641 gccgtacttt gtcgatacgc tctatatatc atggcggcta cctccattag ccgccgtttt
     8701 tacggtgtta gggtcgtcgt agacttgccg ataggcaaaa agaagcggcg gctctgaaaa
     8761 tcaaagccgc cgtaatttag aaatggcgcg tgaaaatacc tctgctttgc gacggctttt
     8821 tttcttttgc cgtcgtccgg cagattattt ttttatgagt aagggcgaaa aatcaatcgt
     8881 aatcataaaa ttatggtcat gtatttcaat tattggattt gtacaattca tcataagtaa
     8941 tagctttttc acaatgtaaa gtccttgtcc agacgtacca ttacttcttg aaacatctgc
     9001 tacataaaag cgttccaaca gttttgaata ttcttctgta ggaatagatg caacaggatt
     9061 tttaatacag agttgtacag aatctgcaat attaattagt tgaattacaa cattatttgt
     9121 agtggatgtt accgcattga atataagatt ttgtataatg cgaatacacg cctttctgtc
     9181 agcattaaga tagatgtcca tattaggtat ttctatttgg ggttcaattc cattaacgct
     9241 gaaaatcgaa taattgtcta gcaggatttc agtaagcaat gagcatagct caaccttttc
     9301 atagtaaaat ggatattgtc ctgcttctaa aagagagatt tgataaaagt catctatgag
     9361 acgttctaat ctcaatgctt ttccggataa tgctgaaata tattccgctc ttttttcatc
     9421 aggcgcactt gatagaagtt gcaaatatcc gcgaatggaa gttagtggtg tccgtaaatc
     9481 atgagaaagg caagaaatat tctcttttaa ttcattctcc tttttttgaa tttcgcccag
     9541 ataaatatta tcttttgata caatctgatt tatgatttca accaaatgct ctaaccgcct
     9601 atcagataaa gacactgtaa ctaacttttt cgtttttcta ttcagaatag catttagttg
     9661 gacgattact ttatatatct gtattttcca gttaattaaa gaaattgaaa ggataatgac
     9721 caatgctatc agaacaagaa acataatcgc ccaacccata ttctacctcc cttttacttg
     9781 atttcttttc taatcataat aagaccgcca acaatcaaaa gagaaatgca ccctatgaaa
     9841 tagaatggta aatgctcaat aatacccatt gtgcgacaag agctgaaatt catccaatag
     9901 tacataggat ttccatatac aaaaaatttt aagggtattg aaaccgtctc catatcactc
     9961 catagcatta agtaaacaga cgctccactg aatacatata agcagcaaat ccctgttaca
    10021 atccctgtat tttgaataac gacacataaa aaaatagaaa tgctttctaa tgctaataaa
    10081 accgttccgc aagcaagagc ccatcccaaa aggtttatta cttcactcgc agttggaatg
    10141 taaccggatt gtatgatttc aataacgaaa aatgtagcta caaaaatcag atacgttatc
    10201 agagacacca ccaatattgt aatcgctttg gtgtagtaga gaatagttcg tttagtgccg
    10261 tatgcaacag ataatttgat tgtacccgta ttatattctt ttgtaaaaaa tatggttgca
    10321 aataaaatgc caataatcca gaaaaaggct gtatatgcaa gagatgagcg ggcaacagtt
    10381 tgaaacgttg gtatttcact agatagataa cacttagctt gaaatccgat tacactttct
    10441 gttccatctc cggctccaaa aaaagtcatg tcaccaagtg caaaagagac cattataacc
    10501 gccgcacata cgcctaatat agttatcaat atctttgagt gacgcaattt ataaaattca
    10561 gctttaaaat ggttaatcat tttggcaccc tcctatcaaa ttagtgtaat aagtttcaag
    10621 actatctcca gattgtgcta actgataaat cgtaatatta tttgcactta gcaacgctga
    10681 tacttttccg gcattttcaa cataatcata tagatgaata cttttgtctg gcataacaga
    10741 aaaatttgaa gtattcagtt tgctttccaa taaaacacta gcagcagcta catcattcac
    10801 ttgcaacaac aaatgctttt tgcagcgttt gtctaaccct gtagcggtaa tttcctgtaa
    10861 aagtttcccc tcatgtaaga taccatatct atttgctaat tgatgaagtt ccgtgagaat
    10921 gtgacttgaa atcaaaatag tgattccacg ttctttattt agtcttttga gtaagtttct
    10981 taattcgata attccagtag ggtctagtcc gttaattggt tcatctagta cgagaaattc
    11041 aggattccca agcaaagcga ttgcgagagc tagtctctgc cgcataccca aagagaaatc
    11101 ttttgctttt ttctttccgg tatctttcaa accaactaat gctaaagcat tatcaatgca
    11161 accttttcct ggaataccgc gttgcaaacg ttgtacctcc aaattttcat aggctgtcat
    11221 atcaagataa agagaagggc tttcaataat acagccaatg cgctcacgct gctttgcaag
    11281 tttcttattg ctttcaccga ataaagcaat tttgccagta gtaggttctg ccagtccggt
    11341 tagtaaacga atcattgttg ttttaccggc accgttttct ccgataaacc cataaatatc
    11401 tccttgcatt acagacatag atacttgatt tagggctagt gtattgcgat acttttttgt
    11461 gatgttgata gcttcaaaaa ctgttacgtt cattttttca cagctccttt cttgttattt
    11521 agtatcgcag acaattcctt gaataatcta aaggtaaagc taaagattat ctaaagctca
    11581 ctttgcaaat cggtaaccca agccccatat ggtcttaatt cggcagcctt cgccctttaa
    11641 tttttttcgt aagttactta tatgtgtgtt aatgacatca ttatcccttg caaatggttc
    11701 ttgccaaata ctttcataaa gattttgctt agaaaaaact ttatcaggat atttcgccag
    11761 tagttctaca agttgatact cttttgctgt aagcacaata atttcgtctg caacagtaac
    11821 tatttttgaa gatgtattaa tggaaagttc tccaaaggtc aaacaaagat tgggagtatc
    11881 tttttgactt cttagcaaat tgcgttcaat tcgcgctagt aattcgtcca aatcaaacgg
    11941 ctttgttaaa tagtcatcag cacccaagcg tagcagttcg actttgttga atgttaaact
    12001 ttttgcagaa acaacaatta caggtacgtc tgaaaatttt ctgatatttc taattaactc
    12061 atctccactg ataaaaggaa gcattaaatc taaaataatt aaatctgggg ataattcttt
    12121 tatacgttca atcgcatttg caccagtaag tgtgaagaag acttgataat tgtacttttc
    12181 cagatggtct tttatcataa cgcaaatttc tttatcatct tcgataatta aaacattatt
    12241 catgttgaaa ctcctttctg cgtctatcag ttggcttttc cacgtctttt ggtatcagcc
    12301 acatactacc aaattttgaa acgcccggta tgcgctcccc ctcacaaagt ttctgcaccc
    12361 gtctttctga aatgccccat ttgcccgctg cttctgcaca agacatatat tccataagcc
    12421 acccgtcctt tcttcaaagt ttatcagtat aattatatac ggtatggcga ataatagcaa
    12481 gtgcggaaat aggcattatt taggttcgtt ataggaagta tatagacata tccaagaaga
    12541 aaggggaaca gtaaaatgta actgggtgaa tgaatatggc aaaaagacca gtagaaaagt
    12601 acgacttcaa ggcttttggg caagcaataa agaacgcgcg gaaagagcgc aaagagagcc
    12661 gcaagaaag
//
