LOCUS       c00016_gnlPro..        23249 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HFLFJKGA_16.
ACCESSION   c00016_gnlPro..
VERSION     c00016_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 23:36:21
            Original ID  :: gnl|Prokka|HFLFJKGA_16
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2048
            Orig. end    :: 25297
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..23249
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[12048:15297]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13249
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..23249
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..23249
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             1414..2871
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_4"
                     /sec_met_domain="FGGY_C (E-value: 1.9e-37, bitscore: 120.6,
                     seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="FGGY_N (E-value: 2.1e-80, bitscore: 261.4,
                     seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYYIGIDLGTSAVKLLLMEESGKICNIVSREYPLFFPHPGWSEQK
                     PEDWFAQSMEGMKELTKDIDRAQVAGIGFGGQMHGLVTLDKDDNVIRPAILWNDGRTGE
                     ETEYLNTVIGKDKLSQYTANIAFAGFTAPKILWMQKNEPENFKKVVKIMLPKDYLAYRL
                     SGSFCTDVSDASGMLLLDVKNRCWSKEMLEICGITEEQLPKLYESWEVVGTLKPEIAKE
                     LGFSENVKVVAGAGDNAAAAVGTGTVGDGQCNISLGTSGTVFISSKNFGVDENNALHSF
                     CHADGSYHLMGCMLSAASCNKWWAEEILQTKDFAAEQAPIQKLGENHVFFLPYLMGERS
                     PHNNPDARGVFFGMSMDSTRADMTQAVLEGVAFGLRDSLEVARGLGIKIERTKICGGGA
                     KSPLWKKIIANVMNLKVDVLENEEGPSMGGAMLAAVGCGAYPDVETIGKKFAKVVDTVE
                     PDPELVAKYEERYQKFRTLYPAMKPLF"
     CDS             complement(2983..3918)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     58.5; E-value: 1.6e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg16_5"
                     /sec_met_domain="LysR_substrate (E-value: 1.6e-33,
                     bitscore: 107.5, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 1.3e-18, bitscore: 58.5,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQGMEYIYEVYKEKSFSKAAAALFISQPSLSANVKRVENHIGYP
                     IFDRSTKPLQLTEVGKHYIQAVEKVMDIENNLENYLLDLGNLKTGTLNVGGSNFFSSWI
                     LPPLIADFSQKFPHVQISLVEESTAKLSQFLQAGKLDLVIDNCILDNQIFERYIYQKEQ
                     LLLAVPKNYSINTRLQKYQIPIEEIRNGQFRSSHIPSVPLNKFENEPFIILRSDNDTGK
                     RALTICQENHFSPSVVFRLDQQMTAYNIACLGMGITFIGDLLLSRVPTNSELVFYKLPG
                     QSSKRTVFFYWKKGRYISRAMEEFLKLPFS"
     CDS             4034..5458
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lyase_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FumaraseC_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_6"
                     /sec_met_domain="Lyase_1 (E-value: 1.2e-94, bitscore:
                     308.9, seeds: 17, tool: rule-based-clusters)"
                     /sec_met_domain="FumaraseC_C (E-value: 4.4e-22, bitscore:
                     70.1, seeds: 737, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTDYRVERDSIGVKDIPEDVYYGVQSLRAAENFHITGLNMHPE
                     IINSLAYIKKAAAITNCEVGLLEKKKAQAIVQACDEIVSGKFHNEFIVDPVQGGAGTSL
                     NMNANEVIANRAIEILGGKKGDYTIINPNDDVNCGQSTNDVIPTAGKMTSLRLLQNLKK
                     QLLRLYDALNEKATEFDHIIKMGRTQMQDAVPIRLGQEFKAYSVAIMRDIHRMDKAMDE
                     MRTLNMGGTAIGTGINADEGYLRRIVPNLTEISGMDFIQAFDLIDSTQNLDPFVAVSGA
                     VKACAVTLSKMSNDLRLMSSGPRTGFGEINLPAKQNGSSIMPGKVNPVIPEVVNQVAFN
                     IIGNDVTITMAAEAGQLELNAFEPIIFYCMFQSIDTLGYAVQTLVDNCIVGITANEERC
                     RYLVENSVGIITAISPHLGYQKAADIAKKAIKTGESVRSLILKEKLMDEDELNRILDPI
                     HMTEPGISGKDYLIKK"
     CDS             complement(5567..7252)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FTHFS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_7"
                     /sec_met_domain="FTHFS (E-value: 2.2e-275, bitscore: 905.7,
                     seeds: 408, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFKSDIEIAQECEMLPITQIAEKAGIDDKYLEQYGKYKAKIDYN
                     LLKESDKKDGKLILVTAINPTPAGEGKTTTTVGLADGMQRLGKSVMVALREPSLGPVFG
                     VKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMIDNHIFQGNALNIDPRKIT
                     WRRCVDMNDRQLRNVVDGLGGKTNGMPREDGYDITVASEIMAVLCLASDIKDLKERLSK
                     IIIGYTYGKVSEQKPVTAGDLHAEGAMTALLKDALKPNLVQTLEHVPAIVHGGPFANIA
                     HGCNSVTATKMAMKLADYAITEAGFGADLGAEKFLDIKCRMAGLKPSAVVIVATVRALK
                     YNGGVAKADLNNENLEALEKGIPNLLKHVSNIKNVYKLPCVVAINAFPTDTKAELDFVE
                     AKCKELGVNVALSEVWAKGGEGGIKLAEEVIRLVEEPNDFSYAYELEGSIEDKLNQIVQ
                     KVYGGKKVVLTANAQKQAKQLEALGFGNCPICVAKTQYSLTDDQTKLGAPTDFEVTVRN
                     LKISAGAGFIVALTGEIMTMPGLPKVPAAERIDVDETGKITGLF"
     CDS             8541..9998
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_8"
                     /sec_met_domain="OKR_DC_1_C (E-value: 2.2e-13, bitscore:
                     42.4, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 2.8e-126,
                     bitscore: 413.0, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYERQQHAPIYEALERFRKKRVVPFDVPGHKRGRGNPELAQLLG
                     EKCVGLDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSAVQSMILSVC
                     KAGDKIILPRNVHKSAINALVLCGAIPVYVNPEVNAQLGISLGMEVSQVEKAMDENPDA
                     VAVLVNNPTYYGICSDLRTIVKKAHARGMKVLADEAHGTHLYFGRNLPVSGMAAGADMA
                     AVSMHKSGGSLTQSSLLLLNKSMNAEKVRQIINLTQTTSASYLLLSSLDISRRNLALRG
                     EESFEKVAGMAQYAREEINEIGGYYAYGMDLINGTSVFDFDVTKLSIYTLGNGLAGIEV
                     YDLLRDEYDIQIEFGDICNILAYISIGDRLQDIERLVGALADIERLYKKDSTGMLSGEY
                     IAPAVVASPQQAFYAEKESLPMEQTAGRISGEFVMCYPPGIPILAPGEMVTQEIVEYIL
                     YARDKGCSMQGMEDPKVEYLQVLKGGI"
     CDS             10001..10861
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_9"
                     /sec_met_domain="Spermine_synth (E-value: 1.6e-53,
                     bitscore: 172.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 2.3e-15,
                     bitscore: 48.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFV
                     ALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDV
                     VESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKARYDLIINDSTDPLGHT
                     EGLFTKEFYGSCYKALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHI
                     PTCPSGYWLFGFASKKYHPLEDFRPERFDNLNIETWYYTTNLHRGAFMLPKYVEDLLEE
                     EENSL"
     CDS             10858..12138
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_10"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 1.9e-43, bitscore:
                     141.1, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 9.5e-36,
                     bitscore: 114.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLLVIGCGGVASVAIRKCCQNSDVFTEIMIASRTKEKCDALKK
                     KIESTTKTKIETAKVDADNAAEVAELIRAYKPDAVLNVALPYQDLTIMDACLEAGADYI
                     DTANYEAEDTEDPTWRAIYEKRCKEKGFTAYFDYSWQWAYNEKFKEAGLTALLGTGFDP
                     GVTSVFSAYALKHYFDEIHTIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWEDGH
                     WVETEPMEFKSVYDFPEVGKKDMYLLHHEEIESLAKNIPGVQRIRFFMTFGQSYLTHMK
                     CLENVGMLSTAPVEFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGKEK
                     SIYIYNVCDHQECYKEVESQAISYTTGVPAMIGSMMVVTGQWKKPGVFNVEEFDPDPYM
                     EALNKWGLPWKVCEDPELVKVWKANED"
     CDS             12128..13249
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_11"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 5.6e-15,
                     bitscore: 47.2, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKINQLQTPCYVIDEKKMRENLEILKKVQEDTGCKILLAQKAFSG
                     FALYPMIGKYLAGTTASGLFEARLGYEEMGKENHVFSPAYRTEDIEELDRICDHIIFNS
                     TAQLKKFKEVCTGASLGLRINPECSTQGDHAIYDPCAPGSRLGVTRENFDGECLKWIDG
                     LHFHTLCEQNADDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYNVKLLEKCIQH
                     MKETYDLDIYLEPGEAVALNAGYLVTEVMDIVENEIRTLILDASAACHMPDVLEMPYRP
                     PLKDSGEAGEKAYTYRLSSCTCLAGDVIGDYSFDREIQIGDKLYFMDMAIYSMVKNNTF
                     NGMPLPDIAVMHEDGECEVIRHFGYEDFKSRLS"
     CDS             13284..14387
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_12"
                     /sec_met_domain="PAD_porph (E-value: 1.4e-127, bitscore:
                     417.0, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVTEKNRTKYRMPGEFEPHEGCVMIWPERPGSWNYGAREAQKAF
                     VKVAEAIGVSEKVYMLVSKAQMENAKNQLGNVSGVTLLECETDDAWARDVGATMVLDEK
                     GAVCGVDWQFNAWGGTFDGLYRNWEKDDRVAAFICRTLGCPCLDARPFVLEGGSIHSDG
                     EGTLIVTEACLLSQGRNPQMSREQIEEQLKYWLGVHKIIWLPCGIYQDETNEHVDNVCA
                     FVRPGEVVLAWTEDETDPQYAMSLADLKVLEQETDAKGRKFKIHKLPIPQKPVCLTQED
                     VDGFVFEEGEDEREAGERMAASYVNFYISNGGIILPQFGDENDKRAVEILQKCFPERRI
                     YPIDARAIIVGGGNIHCITQQIPGKNI"
     CDS             14489..15367
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_13"
                     /sec_met_domain="CN_hydrolase (E-value: 5.4e-56, bitscore:
                     181.4, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNVTVAAVQMKCSKSVEKNIAHAEELVRQAAAKGAEIVLLPELF
                     ERPYFCQERRYEYYEYAQTAEENPAVRHFSRVAAELGIVIPVSFYEKEVNNTYNSVAVL
                     DADGKNLGIYRKTHIPDDHYYQEKFYFTPGDTGFKVFDTRFGTIGVGICWDQWFPETAR
                     CMALQGAELLFYPTAIGSEPILECDSMEHWRRCMQGHAASNLIPVIAANRIGEETVEPC
                     PENGMQKSALNFYGSSFITDNTGALCAELPGGEEGVLVSTFDLDALKADRLNWGLFRDR
                     RPEMYAKIVGK"
     CDS             15567..16028
                     /locus_tag="ctg16_14"
                     /transl_table=11
                     /translation="MNRKEFLEILRSQLAGQMQEGKAAAHIRYYEDYIQSQVRGGRSEQ
                     EVLQELGDPHLIAKTLIDTDDGSTQEDYGEYSSYGSSYGNETELPHQQEKRWKKVIDLS
                     TWHGKAVVIAAAAVIIVLLILIIGVAIPFFIILAIILYFLSWLKKRNDQ"
     CDS             16231..20928
                     /locus_tag="ctg16_15"
                     /transl_table=11
                     /translation="MKHNFKLKERLGALLLAMLFILQAILGLVPVCVTQAAPLTVETWD
                     SDKVVDYGYRFNMKFQPGITTYESFGCDNLDREAFSDNGKSERDTECVRVGADYKAGSA
                     GMRYNNVGKDGNGNIVDVRLILVGVENAEPRYDLRTAESIVQNKGGATFAWKDNEAYPM
                     VGFSKNSIGVFIYSVGYAKVKFQFLKHGTEETLPISGHGTIRDIDAGQGVRIPSDSSLD
                     NAYVLKNNDYLTVDGNSVSSPLGSVEPDDPRGWLNLFYNTDNFTVEFCHQFRLDKWDKS
                     REDAIAKAGSQERWAEITRNKYLDPSGNSYCPNFKGQKYCKAYAYFDFTSYCFGDVEMK
                     KAPEKRVGEANCTWEQAAATSKEKPFGIRQGQEFQYMIRAEVTPNRLKSFVVQDILEDC
                     LTIEDASKVSIVNDAGQTVTDWFDVAVEGQKVTCRAKAESLQDEAFTDNQTYTFTLKVR
                     QRPESEINISKYLAEDGYSILVPNHASMSYERTNGSGDTMDTETVWVKGVIPPELEVKK
                     NTSQYEWKTGDIIDYEVLVSQTKQDVKAVNVVITDELPSCLQFLEGQYAVETSQGGENC
                     TLTGQGENGWKAECPSLKYGETITIRFKCQASADSNGQEWENIVTATADNLINPETGEQ
                     ESRKDMAEVWPNSPQLEIDKTADKYEWQAGEQVAYRIVVNNVTAGTIAKDVTITDIGLP
                     QGLVLAGGAQSMEVLGVQQQVNYPVPDKKTGQAYEARSVDSQLNADENGFSFYCSYVPY
                     SQPVTIIFHCIAQEEANGHESVNAATVKAANTDERSDDAEVYVNSGEFWIEKSADHYEW
                     QVGEQVQYNVVVENKKAGTVARNVTVWDTGMPAGLALSSAEDVSVSGIPQNITQLTAGT
                     KDVLNQLNPEFYNETSEKPVNYEFLQEGSGWRLNISDLPANTPVMISFLCTVAEAANGM
                     ESINVANVQAQNAPVSQDDAEVYVNTAVLSIEKSFQNPYLAAGDGRAENEFRVGEQVNY
                     QVTVNNLQKGSIARNLVISDLSLPEGLALDGAEDAVTVSGVPAVIQNPVAGTDDAGNQL
                     NPENYKETVEKPVSCQVTRQGTGWIVTISDLPYQTPVTVNFRCTAQESVNGMEIVNTAQ
                     AYADNAQKVKDSSKIWVNSPVLNVEKTTDKPFYKYGDIITYRIVLTQEQTGCVARNVTL
                     QDVIDTQGVRLLKDSVILMDEKGNVADADVQINDDNTFLMSTGRTLVRDSRYSICDNDK
                     GGLFEQVMYNPLDCQEQKSMIVEYQAAVIDAALAGQKVHNTAVADSSEKIPATGETETE
                     VHSPILEIVKESDKKEYASGEKGYYKLTVRQLREDVTDQNIVIEDKLETQGASIVKDSI
                     FVKKNGIELKDAKIEADDTGFVIQTGASLSDMDKIEVCYEVVFKTESTEPEKIVNTAKA
                     RGDISPEIAAQQEVYVKTKAEPTATPTPSATPKPTETPKPTETPKPTEVPKPTEQPKAT
                     PTPSVPGTCPKMTPVPTKAPLASYNGGNNGGTTSGNGGSSYGNSGGYGSYQGGSMAGSS
                     KTGDVRPFKMMAVLGLIGMGLLTGGVVIYRRTVSGKRNIKGMPRK"
     CDS             20925..21812
                     /locus_tag="ctg16_16"
                     /transl_table=11
                     /translation="MKKLRTFAVSMIIAAIGLLIYCAGFYIKSYEQNLAARQEYAELSK
                     MAGVKNRAGAGLLADGKKTDEDSSTKNSEKKRRKKQRRSSESKNKNCTDEIRESFGISW
                     ENLRKINSQTVAWITVPGADISYPVVQAADDEYYLKHNFRGEEDLFGCIFLEHDIKKNF
                     TDSHSILYGHNIEGNMMFANLNRYEQPEFLKKCPEIEITTPKRKFLYKIFSVEQASSQS
                     PAFEYGYKLSSPAYRRQLSILKNNSMYDTGVEPDERERMVTLITCNSRLDKEIRMAVHG
                     ICHECYGIEKAEPK"
     CDS             22004..23095
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043:Periplasmic binding protein-like domain (Score:
                     107.3; E-value: 3.4e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_17"
                     /sec_met_domain="Peripla_BP_3 (E-value: 2.7e-33, bitscore:
                     107.3, seeds: 83, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDNGKPKYFSLMEQLRSDIMSGAIRPGEKLPSENELSQKYSLSR
                     HTVRKALGILEQDGYVEAFHGRGTYCSENMRHIKNSKNIAVVTTYISDYIFPRLIQGMD
                     NVLSESGYSIILKNTANSRQKEARCLEELLKKDIDGLIIEPSKSEMICKHRNLYQNLDK
                     FEIPYVFIQGIYSEMRDKPHILMDDAQGGYLVTKYLLELGHKKIKGFFKADDMQGLERH
                     KGYVKALQESGIAYDPDDVVWFHTEDRKVKPALMAKEMVQSGQLPDGIVCYNDQIAVQV
                     MEELEKMGVRIPDDISITGYDNSLYAQRGSGITTIAHPQEKLGEMAAELILEKINGVPE
                     EESKVERLIYPELIIRGSCRKIL"
ORIGIN
        1 ggaaacttcg gacctgaaac tcctgaaact ctgatcgcag agagatttga cggaccttgt
       61 atgtatgtag cagcagcaga aggtgacggt gatatgatca acggcagagg tgatgcttac
      121 tgtggtatgc ttaactgctc ctacaactta aaaatgcgtc atctgaaagc atatattccg
      181 gaataccctg ttggaacagc agatgatatt gcaaagatga tcgctgattt cgtaccggtt
      241 gcacgtgcag tcatcggtgt cagcaatctt aagatcatta ctttcggacc acgtccacag
      301 gacttcttcg catgcaacgc acctattaaa ggcctctatg agctgggtgt tgagattgaa
      361 gagaactcag agcttgatct tcttgtttct ttcaaagagc atgaaaatga tcctcgtatc
      421 ccggaagttt gtgcagatat ggcaaaagag atgggcgaag gcaaatatta tgctgacctt
      481 aatgtgaaaa tggcacagtt tgagcttaca cttcttgact gggcagaggc tcataaggga
      541 gcaagaaaat acgttgcatt tgctgacaaa tgctggcctg cattcccgtc acagtttgga
      601 tttgaacctt gctatgtaaa tagccgtctg gtttccagag gaattccggt atcctgtgag
      661 gttgatatct acggagcact cagcgagtac atcggacttt gcatttccaa tgatgcagtt
      721 acactgcttg atatcaacaa ctctgttcca cagtatatct atgatgaaga tattaaagga
      781 aaatacgatt ataagcttac tgatacattt atgggattcc attgtggaaa tactcctgca
      841 tgcaagatgt gtgattccag agctgttaaa tatcagctga tccagcacag acttcttgag
      901 ccggcaggat ctgaaccaga tttcacaaga ggaactcttg aaggtgatat cgctgcatct
      961 gacattacat tctatcgttt acagtgcaat tccgagggcg agctggtttc ttatgttgca
     1021 gaaggtgaag tactggatgt acctacaaga tcattcggtg gtatcggtat tttcgcaatc
     1081 aaagaaatgg gaagattcta ccgtcacgta ctgatcgagg gcaactatcc gcatcatgga
     1141 gcagttatgt ttggacatta cggaaaagca ttctatgagg tagtgaaatt ccttggactg
     1201 gatgttaaga agattggata taaccagccg gcaggtgtaa gatacccgac agaaaatcca
     1261 tggggttaat gagaaatcag taaaacggat tattaatgtt catgtgaagt gaatgaatct
     1321 gaatacagaa taaataaact gacactatat taaaggcatc ccggggcttt gctctgggat
     1381 gtattagatt agaaatagaa aaggagagca cttatgtatt atattggtat tgaccttggt
     1441 acttccgctg taaaacttct tcttatggaa gaatcaggaa aaatctgtaa catcgtatcc
     1501 agagaatatc ctttattctt cccacatccg ggctggtctg agcagaaacc ggaagactgg
     1561 tttgcacaga gtatggaagg tatgaaagag ctgacaaagg atatcgacag agcgcaggta
     1621 gcaggaattg gttttggcgg ccagatgcat ggtctggtaa cacttgacaa ggatgataat
     1681 gtgatccgtc ctgcaatcct ctggaatgac ggacgtacag gcgaagagac agaatatctg
     1741 aatacagtga tcggaaaaga caaactttca cagtatacag caaatattgc tttcgcaggc
     1801 ttcacagcac cgaagatcct ctggatgcag aaaaatgagc ctgagaactt taagaaggta
     1861 gtaaagatta tgcttcctaa ggattatctg gcatatcgtc tgtccggttc tttttgtaca
     1921 gatgtttctg atgcttccgg tatgcttctt cttgatgtga agaaccgctg ctggtcaaaa
     1981 gaaatgctgg agatctgtgg aatcacagaa gagcagcttc cgaaactgta tgagagttgg
     2041 gaagtagtag gaactctgaa acctgagatt gcgaaagaac ttggattcag tgagaatgta
     2101 aaagttgttg caggtgcagg tgacaatgcg gcagctgctg taggaacagg tacagttggt
     2161 gacggtcagt gtaatatttc tcttggaaca tccggaactg tgtttatttc cagtaaaaac
     2221 tttggtgtgg acgaaaataa cgcacttcat tctttttgtc atgcagatgg aagctatcat
     2281 ctgatgggat gcatgctcag cgcagcttcc tgtaacaaat ggtgggcaga ggagattctt
     2341 cagacaaagg atttcgcagc agagcaggct ccaattcaga agctgggaga gaatcatgta
     2401 ttcttccttc catatttgat gggagaacgt tcacctcata ataatcctga tgcaagaggt
     2461 gtattcttcg ggatgtccat ggacagcaca agagcagaca tgacacaggc tgttctggaa
     2521 ggtgttgcct ttggtcttcg tgattccctg gaagttgcaa gaggccttgg aatcaagatt
     2581 gagagaacca agatctgcgg tggcggagct aagagcccac tgtggaagaa gattattgca
     2641 aacgttatga acctgaaggt tgatgttctg gagaacgaag aaggaccgtc catgggtgga
     2701 gctatgctgg cagcagtagg ctgtggtgct tacccggatg tagaaaccat cggtaagaaa
     2761 tttgccaaag ttgttgatac agtagaaccg gatcctgaac tggttgcaaa atatgaagag
     2821 agatatcaga agttcagaac tctgtatccg gcgatgaagc cattgttcta atcgaatatc
     2881 tgcctgacat actggggttg ttgtgcttat ttagcacaac aaccccattt tgacgtacat
     2941 ctgatgatga ccaatcacca tagcctattt gattatgaca tatcaggaaa agggcagctt
     3001 caggaattct tccatggctc tgctgatata gcggcctttc ttccagtaaa aaaacacagt
     3061 gcgtttactg ctctgaccgg gcagcttata aaaaacaagt tctgaatttg ttggaactct
     3121 ggagagcaga agatccccga tgaaagtgat acccattccc aaacatgcaa tattataggc
     3181 agtcatctgc tgatccaggc gaaatactac agaaggcgaa aagtgatttt cctgacaaat
     3241 ggtaagtgca cgcttaccgg tatcattatc tgaacgaaga ataataaatg gttcgttctc
     3301 gaatttgttt aatggaacag aaggaatatg agaagaacgg aactgcccgt tccggatttc
     3361 ctcaatagga atctgatatt tctgcagtct ggtattgatt gaataatttt tgggaactgc
     3421 aagaagaagt tgttctttct ggtagatata acgttcaaaa atctggttat ccagaataca
     3481 gttatcaatc accagatcta actttccggc ctggagaaac tgggatagct ttgctgtact
     3541 ttcttctaca agagaaattt gaacatgggg gaatttttgg gaaaaatcag caataagggg
     3601 aggcagaatc cacgaagaaa aaaagttact gccacctaca ttaagagttc ctgttttgag
     3661 atttcccaga tccagtaggt agttttcgag attattttca atatccatga ctttttcaac
     3721 agcctgtata taatgttttc caacttcagt taactgcaaa ggtttggtac ttcgatcaaa
     3781 aataggatag ccaatatggt tttccacacg ttttacattg gcgcttaaag aaggctgcga
     3841 aatgaaaaga gcagcagcag ctttggaaaa gcttttttcc ttgtagacct catagatgta
     3901 ttccattccc tgaaacatat aaactcctcc gatatataac ttaaacacta tatattttat
     3961 aaaaatatat gtatttgatt atattatagc agagatatat aatgagggca aatacatggg
     4021 agggcgaata actatgaaaa aaacagacta tcgtgtagaa agggattcta ttggtgtaaa
     4081 ggatattccg gaagatgtat attatggagt acaatcctta cgtgcggctg aaaatttcca
     4141 cattacgggg ctgaatatgc atccggaaat tattaacagt cttgcataca taaaaaaagc
     4201 agcagcgata accaattgtg aggtggggct tcttgagaag aaaaaagcac aggcgattgt
     4261 ccaggcatgt gatgaaattg tttcaggaaa attccataat gaatttattg tggatcctgt
     4321 tcagggagga gctggcacat ctttaaatat gaatgccaat gaagtaattg caaatcgcgc
     4381 gattgagata ctgggaggaa aaaagggcga ttatacaatt ataaatccta acgatgatgt
     4441 gaattgtgga cagtctacca atgacgtgat tcctactgcc ggtaaaatga cttctcttcg
     4501 tttgttgcag aatctgaaaa aacagcttct tcgcctctat gatgctctta atgaaaaagc
     4561 tacagagttt gatcacataa taaaaatggg gcgtacacag atgcaggatg cagtaccaat
     4621 tcgtctggga caggaattta aggcatattc ggtagcaatc atgcgtgata tccacagaat
     4681 ggataaagca atggatgaaa tgcggactct taatatggga ggtactgcta ttggaacagg
     4741 aattaatgca gatgagggct atctgagaag aattgttcca aatctcactg aaatatcggg
     4801 aatggacttt atacaggctt ttgatctgat tgattccact cagaatctgg atccatttgt
     4861 agctgtttcc ggtgctgtga aagcatgtgc ggtaactctt tccaaaatgt caaatgatct
     4921 ccgtctgatg tcctccggtc cacgtactgg ttttggggag attaatcttc cggcaaaaca
     4981 gaatggttcc tctattatgc caggtaaagt taatccggtt attcctgaag tagtgaatca
     5041 ggttgctttt aatattattg gtaatgatgt taccattacc atggctgcag aggctggtca
     5101 gctggaatta aatgcgtttg agccgattat tttctattgc atgtttcagt ctatcgatac
     5161 tcttggctat gcagtccaga cattggtaga taattgtatt gtaggaatta cggcaaatga
     5221 agaaagatgc cgttatctgg tagaaaacag tgtaggtatt atcactgcaa tcagccccca
     5281 tcttggatat cagaaggctg cggatattgc aaaaaaggca attaagacag gcgaatctgt
     5341 aagaagtctg attctgaaag aaaagcttat ggacgaggat gaacttaatc gcattctgga
     5401 tccgatccat atgacggaac ctggtatttc cggaaaagat tatcttataa aaaaataaag
     5461 aaaaaaacag gcgggaaaat cttcccgcct gtaaaatcgt ctggacacat atcatatata
     5521 aatatgattt ttatattttt gaattattcg attgatttca accggattag aacagacctg
     5581 tgatcttacc tgtctcgtct acgtcgattc tctcagcagc cggaacttta ggaagacctg
     5641 gcattgtcat gatctcgcct gtaagagcta cgatgaatcc tgcaccagcg gaaatcttca
     5701 ggttacgtac tgtaacttcg aagtcagtag gagcacccag tttagtctgg tcatctgtta
     5761 agctgtactg tgtcttagct acacagatcg ggcagttgcc aaagccaaga gcttctaact
     5821 gtttcgcctg tttctgagcg ttagctgtca gaactacttt cttaccgcca tatactttct
     5881 gaacgatctg gttcagtttg tcttcgatag aaccttccag ttcatatgca taggagaagt
     5941 cgtttggttc ttcaacaaga cggataactt cttctgcaag tttgattccg ccttcgccgc
     6001 cttttgccca tacttcagaa agagcaacgt taacgcccag ttctttacat ttagcttcta
     6061 caaagtcaag ctctgctttt gtatctgtag ggaatgcgtt gatagcaaca acacatggaa
     6121 gtttgtatac gtttttgatg ttggaaacgt gttttaacag gttcgggata cctttttcaa
     6181 gagcttccag gttttcattg ttaaggtcag ctttagcaac gccgccgttg tatttcaggg
     6241 cacgtactgt agctacgatt acaactgcgc ttggttttaa accagccata cggcatttga
     6301 tatcaaggaa tttctcagca ccaaggtcag caccgaaacc agcttctgtg attgcataat
     6361 cagcaagctt catagccatc tttgtagctg ttacagagtt acatccatga gcgatgtttg
     6421 cgaatggtcc gccatgtacg attgcaggaa cgtgttccag agtctgtaca aggtttggtt
     6481 tcagagcatc ttttaacagg gctgtcatag cgccttctgc gtgaaggtca cctgctgtta
     6541 caggtttctg ctcggaaact tttccgtatg tatatccgat gatgatcttg gataatcttt
     6601 ctttcaggtc tttgatgtcg cttgcaagac agagaactgc catgatttca gatgcaactg
     6661 tgatgtcgta tccgtcttca cgaggcatac cgtttgtctt tccgccaaga ccatctacta
     6721 cgttacgaag ctgacggtcg ttcatatcta cacatcttct ccatgtgatc ttacgtgggt
     6781 cgatgtttaa tgcattgccc tggaagatat ggttatcgat catagctgcc agtaagttgt
     6841 tagctgcgcc aatggcatgg aagtcacctg tgaagtgaag gttaatatct tccataggaa
     6901 caacctgtgc atatccgccg cctgctgcac caccttttac accgaatacc ggtcctaagg
     6961 atggctcacg aagagctacc ataacactct tgccaagtct ctgcatacca tctgcaagac
     7021 ctacagtagt agtagtttta ccttctcctg ctggagttgg gttgatagct gtaacgagga
     7081 ttaattttcc atccttctta tcactttctt tcagaagatt gtagtcgatt tttgctttgt
     7141 attttccgta ctgctccaga tatttgtcgt caatacctgc tttctctgcg atctgagtaa
     7201 ttggaagcat ctcgcattcc tgtgcaattt caatgtctga tttgaatccc ataattgttt
     7261 ttctcctttc gtttccgcat aacatgaaaa acttctgttg ctgttcactc cgcgatcagc
     7321 aacaattatt aattgaaaga agtattggcc ggtctgcctg gtattcctga tttctgccct
     7381 gaaagttata aaaaaaggcc agtatctgaa tatttcaaat actgcccaga cggtcggctc
     7441 ccacaaacct ccgactccac gtggtttgca ctccactctt tccgtcagta ctcgaaggtt
     7501 ctttcaattg atgaatacaa tatatcattt tgagaaaaaa atgtcaagaa aatttttgtt
     7561 gaaacgtcaa aaaatgtgag taaactggat aaaagttgtg caaattgata agagaagaga
     7621 atcgtaatcc ctggtaatga aagaaaatac gttttctcaa ggaaagaaat tgttaaaaaa
     7681 tagacatagt tttccctgat aaatgaagaa aatataaaaa gcgggtaaag ctagagcgtg
     7741 tctgaaaaat cattcccgca atctgcacgc cccactttgc gggatatttc acccgaattc
     7801 agttgccgta gcccgctacg gcgccctcat ccgggcaaaa tataccacaa attgtgacgc
     7861 acatcttgca gaaagccttt ttcagacacg ctctagtgca aaatatggaa aatggaattg
     7921 acaacagttc agaagatatg ttattctcat ctttagtatg aaaagacact atcgttttca
     7981 tgcaaatatt tgctcacatt cagagacagt ttctgaatgt taagccatac ggacaggcgg
     8041 ggcagttgcc gggtgggaga caccacatta ttgattgagt tagaagctca aattttataa
     8101 gttgattact ttataataat cagtgcgtaa gcacacatca tcttgtgaaa cggtcaataa
     8161 gagcatagca tatatttgcc agcgattgaa gacgacagca gtcatgaata tttcagaata
     8221 cgggaacagg cacaggatac agacggattt atacgggaaa tccggtcagt atataaagag
     8281 acagagcctg agaaattcta tagatcatga gagaagcaga tggtgaatga acttatctgc
     8341 ttcttttttt gtgcagatat agcaaatata aaggatatgg ttggagataa acgctttgcg
     8401 aggatgtgtc tcacatgcgt tcgacttgaa tatatagaga aataattgaa tcattgtgcc
     8461 ggtttgaggc agtatacaat tgctgaatga tagaactgta tttgccggta catgacgaca
     8521 ggaaaagagg aacatgtcaa atggattatg aaagacaaca gcatgcgccc atatatgaag
     8581 cactggaacg tttccgaaag aagagagtcg ttccctttga tgtgccggga cataaaagag
     8641 gaagaggaaa tccggagctt gcacagttgc tgggagagaa atgtgtgggg ctggatgtta
     8701 attctatgaa gccgctggac aatctctgcc acccggtttc ggtgatcaga gaagcggagg
     8761 agcttgcagc agatgctttt ggcgcagcgc atgcattcct tatggtagga ggaaccacat
     8821 ctgcagtgca gagcatgatc ctgtctgtct gcaaggcagg ggataagatc attctgccgc
     8881 gaaatgtaca taaaagtgcc atcaatgccc tggtactgtg cggtgcaatt ccggtttatg
     8941 taaacccgga ggtgaatgcg cagctgggca tttcccttgg catggaagtc agtcaggtgg
     9001 agaaggctat ggatgagaat ccggatgcgg tggcagttct tgtaaataac cctacctatt
     9061 atggaatctg ttcggatctg cggactatcg taaagaaggc tcatgcaaga ggaatgaagg
     9121 tgctggcaga tgaggctcat ggaacccatc tttatttcgg cagaaacctt cctgtatccg
     9181 gaatggcggc aggtgctgac atggcggcag tttccatgca caaatccggc ggaagtctga
     9241 cacagagttc gctgctgctt ttgaataaga gtatgaatgc agagaaagtg cgccagatca
     9301 tcaatctgac tcagaccaca agcgcttctt atcttctgtt gtccagtctg gatatctcca
     9361 gaagaaatct ggcactcagg ggagaggaat cctttgaaaa ggttgcaggg atggcgcagt
     9421 atgccagaga ggagatcaat gagatcggcg gttattatgc atatggtatg gatctgatca
     9481 atggaaccag tgtttttgat tttgatgtta caaaactctc catttataca ctgggaaatg
     9541 ggctggcagg tattgaagtt tatgatcttc tcagagatga atatgatatt cagatcgagt
     9601 ttggagatat ctgtaatatt ctggcttaca tttccattgg agacaggctt caggatattg
     9661 agagactggt aggggcattg gctgatattg aacgtctgta taagaaggac agcacaggta
     9721 tgctttccgg ggaatatatc gcacctgcag tggtggcgtc tccacagcag gcattttatg
     9781 cggagaaaga atctctgccc atggaacaga cggcaggcag gatcagcggt gaatttgtta
     9841 tgtgttatcc tccgggaatc ccgattcttg ctcctgggga aatggtgaca caggaaattg
     9901 tagaatacat tctttatgca agagacaaag gctgttccat gcagggaatg gaggatccga
     9961 aggtagaata tcttcaggtt ctgaaagggg gtatctgatc atggaattat ggtattccga
    10021 gttccataca ggaaatgtaa agctttctgt ccggattaac cgacagttat tttcagggga
    10081 aagtgaattt cagagaatcg atgtgtttga gtctgaagaa tttggaagat ttgtggctct
    10141 ggacggtgag atcgtatttt ctgacaagga tgaatttatt tatgatgaaa tggtcacgca
    10201 tgtgccaatg acagtacatc ccaatgtaaa aaatgttctg attatcggtg gcggtgacgg
    10261 tggagttgcc agagaactga tccattatcc acagattgag agcattgatg tggtggaatc
    10321 cgataaaatg tttgtggatg tatgtgcgga gatgtttccg gatattgccc agggactgaa
    10381 ggatgagaga gtcaacattt attatgaaga cggccttcgg ttcctgcgga ataaaaaggc
    10441 cagatatgac ctgatcatca atgattccac agatccgctg ggacatacag agggactttt
    10501 tacaaaggaa ttctacggaa gctgttataa ggctctcaga gatgacggaa tcatggttta
    10561 tcagcatgga agtccttttt atgatgagga tgaggtggaa tgcagaaaga tgcacagaaa
    10621 ggttttccgg tcatttccgg tgagcagggt ttatcaggca catatcccta cctgtccctc
    10681 gggatactgg ctttttggat ttgcatcaaa gaaatatcat ccactggaag atttcaggcc
    10741 ggagaggttt gataatctta atatagaaac atggtattat acaacaaacc ttcacagagg
    10801 agcatttatg cttccaaaat atgtagaaga tttactggaa gaggaggaaa acagtttatg
    10861 agtagattat tggtaatcgg atgtggtggg gtagcttcag tggcaattcg caaatgctgt
    10921 cagaacagcg atgtttttac agagattatg atcgcaagca ggacaaagga aaaatgcgat
    10981 gcactcaaaa agaagattga aagtacaacg aagacaaaaa ttgagacagc aaaggtagat
    11041 gcggataatg cagcagaggt cgcagaattg atcagagcct ataagccgga tgctgtcctg
    11101 aatgtggcac ttccatatca ggatcttacc atcatggatg catgtctgga agccggtgcg
    11161 gattatattg atactgccaa ttatgaagca gaggatacag aagatcccac atggcgtgca
    11221 atctacgaaa agagatgtaa agaaaaaggc tttactgcat atttcgatta ttcctggcag
    11281 tgggcttata atgagaaatt taaggaagca ggactgactg ctcttctggg aaccggtttt
    11341 gatccgggtg ttaccagtgt attcagtgcc tatgccttga agcattattt tgatgaaatc
    11401 cataccattg atattctgga ctgtaacggc ggtgatcatg gatatccttt tgccacaaac
    11461 tttaacccgg agatcaatct tcgagaggtt tccgcaaatg gttcctactg ggaagacgga
    11521 cattgggtag aaacagagcc tatggaattt aaatctgtct atgatttccc tgaggtagga
    11581 aagaaggata tgtatcttct tcatcatgaa gagattgaat cactggcaaa aaatattccg
    11641 ggagtacaga ggatccgttt ctttatgaca ttcggacaga gctatctgac acatatgaaa
    11701 tgtctggaaa atgtaggaat gctttccacc gcacctgtgg aatttaatgg acaggagatc
    11761 gtgccgatcc agtttttgaa agctcttctg ccggatcctg catctttggg tccgagaaca
    11821 gtgggtaaaa caaatatcgg ctgtattttc acaggtgtta aggacggaaa agagaaaagt
    11881 atttatattt ataatgtatg tgatcatcag gaatgctata aagaggtgga atcccaggca
    11941 atctcctata caacaggtgt tccggctatg atcggttcca tgatggtagt gaccggacag
    12001 tggaagaagc cgggtgtatt taatgtggaa gaatttgatc cggatccata tatggaagca
    12061 ctgaacaaat ggggacttcc atggaaagtc tgcgaagatc ctgaactggt aaaggtctgg
    12121 aaagccaatg aagattaatc aactgcaaac tccctgctat gtgatcgatg agaagaagat
    12181 gcgggagaat ctggagattt tgaaaaaagt ccaggaggat accgggtgta agatccttct
    12241 ggcgcagaaa gcgttttccg gttttgctct gtatcccatg atcggaaaat atctggcagg
    12301 taccactgcc agcggtctgt ttgaggcaag gcttggatat gaagagatgg ggaaagagaa
    12361 tcatgttttt tcccctgctt accgtacaga agatatagag gaactggatc ggatctgtga
    12421 ccatattatc tttaattcca cagcacagct gaagaaattt aaagaagtgt gtaccggagc
    12481 cagtctggga ctccgtatta atccggaatg ctccactcag ggggatcatg cgatctatga
    12541 tccctgtgcg ccgggttcaa ggctgggggt taccagagag aactttgacg gggaatgtct
    12601 gaaatggatc gacggactgc attttcatac gctctgcgaa cagaatgcgg atgacctgga
    12661 gaaaacattg caggcggtag aggagaagtt tggagaattt ctgtctgagg tttcctggct
    12721 gaatatgggt ggcggacatc atattaccag agaggattat aatgtaaagc tcctggaaaa
    12781 atgtattcag catatgaagg aaacctatga tctggatatt tatctggagc ccggggaggc
    12841 tgttgccctg aatgccggat atctggtgac agaggttatg gacattgtgg aaaatgagat
    12901 cagaacgctg attttggatg cttctgcagc ctgccatatg ccggatgtgc tggagatgcc
    12961 ctatcgtccg cctcttaagg acagcgggga agcaggggag aaggcatata cctaccgctt
    13021 atcttcctgc acctgcctgg caggagatgt gatcggagat tattcctttg acagagagat
    13081 ccagatcggg gacaagctgt attttatgga tatggcgatt tattctatgg tgaagaataa
    13141 tacatttaac ggtatgccgc tgccggatat tgcggttatg catgaggacg gagagtgtga
    13201 ggttatcaga catttcggat acgaagactt taagagccgg ctttcctgat atctgccggg
    13261 ctatcaaaga aaaggagaca gacatggaag ttacagagaa gaacagaaca aaatatcgta
    13321 tgcccggaga atttgagcct catgagggat gtgtgatgat ctggccggaa cgtcccggtt
    13381 cctggaatta tggggcaagg gaagcacaga aagcatttgt gaaagttgca gaggctattg
    13441 gagtgagcga aaaggtgtat atgctggttt ccaaagctca gatggagaat gcaaagaatc
    13501 agcttgggaa tgtttccggt gtgactttgc tggaatgcga gacagatgac gcctgggcca
    13561 gagatgtggg agcaaccatg gttctggatg agaaaggggc ggtctgtgga gttgactggc
    13621 agtttaatgc ctggggaggt acctttgacg ggctttaccg gaactgggaa aaggatgaca
    13681 gggtggctgc ctttatctgc aggactctcg gttgtccatg tctggatgcc agaccttttg
    13741 tgctggaggg cggttccatc cattctgacg gagaggggac tctgattgtt acagaggcct
    13801 gtcttctgag tcagggacgc aatcctcaga tgagcaggga acagatagag gaacagttga
    13861 agtactggct cggtgtccac aagattatct ggcttccatg tggaatctat caggatgaaa
    13921 ccaatgagca tgtggataac gtgtgcgctt ttgtaaggcc cggagaggtt gtgcttgcat
    13981 ggacagagga tgagacagat ccgcagtatg ccatgtcttt ggctgatctg aaggtgctgg
    14041 aacaggaaac agatgcaaag ggcagaaaat ttaagattca taagcttccg attcctcaga
    14101 aaccggtctg ccttacccag gaagatgtgg atggctttgt gtttgaagag ggagaagacg
    14161 aacgggaagc aggagaacgg atggctgcca gttacgtgaa tttctatatt tccaatggag
    14221 ggatcatcct tccacaattt ggggatgaaa atgacaaaag ggcagtggag attctgcaga
    14281 agtgttttcc tgaaagaagg atttatccca ttgatgccag agccatcatt gttggcggtg
    14341 gaaatattca ctgtatcacc cagcagattc ccggaaaaaa tatctgacct tgatgcagaa
    14401 aactttgaga gtcatgtgtt tgagggttat tacctgaaag ttatgaaaaa acttacttat
    14461 gtaaacagga gcaggaggaa cagacaggat gagaaatgta acagtggcag cagttcagat
    14521 gaaatgcagt aaaagtgtgg agaaaaatat tgcccatgca gaggaactgg tgcgtcaggc
    14581 agcagcaaag ggagctgaga ttgttcttct gccggagctt tttgaacggc cctatttctg
    14641 ccaggagcgc agatatgagt attatgaata tgcgcagact gcagaggaaa accctgcagt
    14701 gcgtcatttc agcagggtag cggcagagtt ggggattgtg attccggtca gcttttatga
    14761 aaaagaggtc aataatactt ataacagcgt tgcggttctg gatgcagatg gaaagaatct
    14821 cggcatttat cggaaaacac atattccgga tgaccattat tatcaggaaa aattctattt
    14881 cacaccggga gataccggct ttaaggtttt tgataccaga tttggaacca ttggagttgg
    14941 aatctgctgg gatcagtggt tcccggaaac ggcaagatgt atggcactgc agggagcaga
    15001 gcttctcttt tatcccactg ccatcggaag tgaacccatc ctggaatgcg acagcatgga
    15061 acactggaga agatgtatgc agggacacgc tgcctccaac ctgatccctg tgatcgctgc
    15121 caacagaatc ggtgaggaaa cagtagagcc atgtccggaa aacggaatgc agaaatctgc
    15181 tcttaatttt tacggctctt cttttatcac agacaacaca ggtgctctct gtgcagaact
    15241 gcccggaggg gaagaggggg tgcttgtaag cacttttgac ctggatgcat taaaggcaga
    15301 cagactgaac tggggacttt tcagagaccg cagaccggag atgtatgcaa aaattgtcgg
    15361 aaaatgacga aagcaggaga atccgagtgg atttgcagtg ttatttccaa aacgatatat
    15421 gtgtttataa gaatttcata aaaagtttat gattatatta gttgctacct gcggtatata
    15481 tggtaaaata agagtacgaa cgttactgat aacggagaga gcagtagagt tttgatatgt
    15541 atttctggca aaatggagtg tagaagatga acagaaaaga atttttggaa atcctgagaa
    15601 gccagcttgc cgggcagatg caggagggca aagcagcagc acatatcagg tattatgaag
    15661 attatataca gtctcaggta cgtggcggac gttcagagca ggaagtactg caggaactgg
    15721 gagacccgca tctgatagca aaaactctga tcgatacaga tgatggaagt acacaggaag
    15781 attacggaga gtattcttct tacggaagta gttatggcaa tgagacagag cttcctcatc
    15841 agcaggagaa aagatggaaa aaagtaatcg atctttctac ctggcatggc aaggctgttg
    15901 ttattgcagc ggcggctgtt ataattgttt tactgatact gataatcgga gttgcgattc
    15961 cgttttttat tattcttgca attattcttt attttctttc atggctgaag aaaagaaatg
    16021 atcaatgaaa atctgtgcag ggtttcagaa aagaaaccct gcgcagaatc ttaaaatctt
    16081 aagtgtaaac gttcttgttt cacgatatta attccccttg aatatttata atcatacaat
    16141 ctcaacttat ttctattctt taatcctgcc aggtgcaggg aaaaatccca cattcatttt
    16201 tatatttttt gttcggaaag gagacggaaa atgaaacaca atttcaaact gaaagaacgc
    16261 cttggagctt tgctgcttgc aatgcttttt attctgcagg caattctggg gcttgtgcct
    16321 gtctgcgtaa ctcaggcggc accgttaact gtagaaacat gggacagtga caaggtggta
    16381 gattatggtt atcgctttaa catgaagttt cagcccggaa ttaccacata tgaatctttt
    16441 gggtgtgata atctggacag ggaagctttt tcagacaatg gaaaaagtga acgtgacaca
    16501 gagtgcgttc gtgtaggagc ggactataaa gccggaagcg cagggatgcg ttataacaat
    16561 gtaggaaaag atggaaatgg aaatattgtt gatgtcagac tcattcttgt gggagtagag
    16621 aatgcagaac cccgttatga tctgcgcact gcagaatcga ttgttcagaa taaaggcgga
    16681 gctacgtttg catggaaaga taatgaagct tatccaatgg ttggcttttc caaaaacagt
    16741 atcggtgtat ttatttattc tgtaggatac gcaaaggtta agtttcagtt tctgaagcat
    16801 ggaacagaag aaacactgcc gatcagtggc catggaacca tacgtgatat tgatgcggga
    16861 cagggagtcc gtattccgtc agacagcagt ctggataatg catatgttct gaaaaacaat
    16921 gattatctga cggtagatgg gaattctgta agctcacccc ttggttccgt tgagccggat
    16981 gatccgagag gatggctgaa tcttttttat aatacagata attttacggt agaattctgt
    17041 catcagttca gactggataa atgggataaa agtcgtgaag atgccattgc aaaagccggt
    17101 tctcaggaaa gatgggcaga gattacaaga aataaatatc tggatccatc aggcaacagt
    17161 tattgtccga actttaaagg acagaaatac tgcaaagcat atgcatattt tgattttaca
    17221 tcctattgtt tcggtgatgt tgagatgaaa aaagcgcctg agaaacgtgt gggagaggca
    17281 aactgtacat gggaacaggc agctgccaca tcaaaagaaa aaccttttgg cattcgtcag
    17341 ggacaggaat tccagtatat gatccgggcg gaggtgacac ccaatagact gaaatccttt
    17401 gtggtacagg atatacttga ggattgtctt actatagagg atgcatcaaa agtcagtatt
    17461 gtgaatgatg cagggcagac agtgacagac tggtttgatg ttgctgttga aggacagaaa
    17521 gtgacctgca gggccaaagc agagagcctt caggatgaag catttacaga taatcagact
    17581 tacacattta ctttaaaagt acgccagaga ccggaatcag aaattaacat ttcaaaatac
    17641 cttgcagagg atggatacag tattcttgta ccaaaccatg catccatgag ttatgaacgt
    17701 acaaacggaa gcggagatac aatggatacg gaaacagtgt gggtaaaggg tgtgattcca
    17761 ccggaactgg aagtaaagaa aaatacttct cagtatgaat ggaaaacggg agatatcata
    17821 gattatgagg ttctggtttc tcagacaaaa caggatgtaa aagcagtaaa tgttgttatt
    17881 acagacgagc ttccatcatg tctgcagttt ctggaagggc agtatgctgt agagacaagt
    17941 cagggaggcg agaactgtac gcttaccgga cagggagaaa atggatggaa agcagagtgt
    18001 ccgtccctga agtatgggga gacgatcaca atccgtttta aatgtcaggc atctgcggat
    18061 tccaatggac aggaatggga aaatattgtg actgcaacag cggataatct gatcaatcct
    18121 gagacaggag aacaggaatc cagaaaggat atggcagaag tatggccgaa cagtccacag
    18181 cttgaaattg ataaaacagc agacaaatat gaatggcagg caggagagca ggtagcttac
    18241 cggatcgtgg tgaataatgt aacggcagga acaattgcaa aagatgtaac tattactgat
    18301 attggtctgc cgcagggact ggttctggca ggtggtgcac agagcatgga agtactggga
    18361 gttcagcaac aggtaaacta tcccgtaccg gataagaaaa caggacaggc atatgaagcg
    18421 agatctgtgg attctcagtt gaatgcagat gagaacggat tttcctttta ttgttcttat
    18481 gtgccataca gtcagcctgt aacgattatt ttccattgta tcgcacagga agaggcaaat
    18541 ggacacgaaa gcgtaaatgc agcaactgta aaagctgcta atacagatga gagatctgat
    18601 gatgcagaag tatatgtaaa ttcaggagaa ttctggattg agaaatctgc agatcattat
    18661 gaatggcagg tcggagaaca ggtacagtac aatgtggtgg tggagaataa aaaagcaggt
    18721 acagtggccc ggaacgtaac tgtctgggat accggtatgc cggcaggact tgcgctttca
    18781 tcggcagagg atgtatcggt aagcggaatc ccacagaata ttacgcagct gacagcaggg
    18841 accaaagatg ttttgaacca gctcaatccg gaattttata atgagacatc agagaaaccg
    18901 gtgaattatg aatttcttca ggagggaagc ggatggagac tgaacatttc agatcttccg
    18961 gcaaatactc cggttatgat ttctttcctt tgcacagttg cggaagcggc aaatggaatg
    19021 gaaagcatta atgttgccaa tgtgcaggcg cagaatgccc ctgtttcaca ggatgacgca
    19081 gaagtgtatg taaatacagc agttctttct attgagaaaa gttttcagaa tccatatctg
    19141 gcagccgggg acggacgtgc ggaaaatgaa tttcgggtag gagaacaggt gaattatcag
    19201 gttacggtta ataatcttca gaagggatct atcgcaagaa atcttgtgat cagtgatctt
    19261 tcccttcctg aagggctggc tctggacgga gctgaagatg ctgttactgt aagcggtgtt
    19321 ccggctgtta ttcagaatcc ggtggcagga actgatgatg caggaaatca gctgaatccg
    19381 gaaaattata aagaaacagt ggaaaaaccg gtcagctgtc aggttacacg tcagggaacc
    19441 ggatggatcg tgacgatttc agatcttccg tatcagacac ctgtgactgt taatttccgc
    19501 tgtactgcgc aggaaagcgt aaatgggatg gagattgtaa atacagcaca ggcgtatgca
    19561 gataatgcac agaaagtaaa ggactcctca aaaatctggg tgaactcgcc tgttcttaac
    19621 gtagagaaga cgacggacaa accattttac aaatatggtg atattattac ataccgcatt
    19681 gtcctgacac aggagcagac cggatgtgtg gcgcgtaatg ttactctgca ggatgtgatc
    19741 gatactcagg gagtacgtct tctgaaggat tcggtgattc tgatggatga gaaaggaaat
    19801 gtggcagatg ctgatgtaca gatcaatgat gataatactt tcctgatgtc aacaggcagg
    19861 acactggtca gggacagcag atatagtatc tgcgataatg ataaaggcgg tctttttgag
    19921 caggtaatgt ataatcctct ggactgtcag gaacagaaaa gtatgatcgt ggaatatcag
    19981 gcagcagtga ttgatgcagc cctggcagga cagaaagtgc acaatactgc agttgcagac
    20041 agcagtgaaa agatacctgc aaccggggaa acagagacag aggtacacag tccgattctg
    20101 gaaattgtga aggaatcaga taagaaagag tatgcgtccg gtgagaaagg atactataag
    20161 ctgacagtaa gacaactgcg tgaggatgtc acagatcaga atattgttat cgaagataaa
    20221 ctggaaaccc aaggggcttc tattgtaaaa gacagcattt ttgtgaagaa aaacggcata
    20281 gagctgaaag atgccaaaat agaggcagat gatacaggat ttgtaattca gacaggagca
    20341 tcgttgtcag atatggataa aattgaagtc tgctatgaag tggtatttaa aacagaaagc
    20401 acagagcctg aaaaaattgt aaacacagcg aaagcaagag gagatatttc accggaaatt
    20461 gcggcgcagc aggaggtata tgtgaaaaca aaagcagaac ccactgccac accaacaccg
    20521 tctgcaacac cgaaaccaac agaaacacca aagccgacag agacaccaaa acctacagaa
    20581 gtaccgaaac cgacggagca gccaaaagcc acaccaacac catctgtacc gggaacctgc
    20641 ccgaaaatga ctcctgtacc gacgaaagca ccgttggcat cttacaatgg tggaaataat
    20701 ggaggcacaa cttccggaaa cggaggcagc agttacggaa attcgggtgg atacggaagc
    20761 tatcagggtg gttccatggc aggaagttct aaaacaggag atgtcagacc gtttaaaatg
    20821 atggctgttc ttggacttat cggaatggga ctgctgacag gaggtgtggt gatctacaga
    20881 agaactgttt ccgggaaaag aaatataaag ggtatgccgc ggaaatgaaa aaactcagaa
    20941 catttgcagt aagtatgatc atagcagcaa ttgggcttct tatatattgt gccggcttct
    21001 atataaaaag ttatgaacag aatcttgcag caaggcagga atatgcagag ctttccaaaa
    21061 tggcaggggt gaagaacaga gcaggtgccg gattattggc agatggcaaa aaaactgatg
    21121 aagacagcag tacaaaaaac agtgaaaaaa aacgcaggaa aaaacagaga agatcttctg
    21181 aatcaaaaaa caaaaactgt acagatgaaa tcagggaatc cttcgggatt tcctgggaaa
    21241 atttaagaaa gatcaactct cagacagttg cctggattac tgtcccggga gccgatattt
    21301 cttatcctgt agttcaggcg gcagatgatg aatattacct gaaacataat ttcagaggag
    21361 aggaagatct gtttggatgt atttttctgg aacatgacat aaaaaagaat ttcacagatt
    21421 cccacagtat tctttacggg cataatatag aaggtaatat gatgtttgca aatctgaacc
    21481 gttatgaaca gcctgaattt ctaaaaaaat gtcctgaaat tgagatcaca acaccaaaaa
    21541 gaaagtttct gtacaaaatt ttttctgtgg aacaggcatc ttcccaaagc ccggcatttg
    21601 aatatggata caagttatcc agtcctgcat acaggagaca attatctata ttgaaaaata
    21661 attccatgta tgacacagga gtagagcctg atgaaaggga gagaatggtg actctgatca
    21721 cctgtaattc acgtctggat aaagaaatac gtatggcggt acatgggatt tgccatgaat
    21781 gttatggtat agaaaaagct gagccgaagt gatgttgaaa tcaatcggat attggtaact
    21841 ttcgtaaagg atgaactgtt actgttcaca catcactatc cctcgaggtg ttttggaaaa
    21901 aactaatgaa aaatctctcg atattttgta taatttatgc ataaaaaaca acttgttcgt
    21961 acgtgcgtac aagttgtatc ctaaatacag gagggaagaa gacatgacag ataatggaaa
    22021 gccgaaatat ttctcactga tggaacagct cagaagtgat attatgtcag gagctatccg
    22081 accgggagag aagcttcctt cagaaaacga gctttcacag aaatattcct tgagtagaca
    22141 tacagttcgt aaagcactgg gaatcctgga gcaggacgga tatgtagagg catttcacgg
    22201 aagaggtact tattgctctg agaatatgcg ccatataaag aattcaaaga atattgcggt
    22261 agtgaccaca tatatttctg attatatttt tccgagactg atacagggaa tggataatgt
    22321 cctttcagaa agcggttaca gtattatcct gaaaaacaca gcaaacagca gacagaaaga
    22381 ggccagatgt ctggaggaac ttctgaagaa agatattgat ggactgatca ttgaaccaag
    22441 caaaagtgag atgatctgta aacacagaaa tctttatcag aatctggata aatttgaaat
    22501 tccgtatgtg tttattcagg gaatctattc agaaatgagg gataaacctc atattcttat
    22561 ggatgatgca cagggaggct atcttgtaac aaaatatctg ctggaactgg gacataaaaa
    22621 gatcaagggt ttctttaagg cagacgatat gcagggactg gagcgccaca agggatatgt
    22681 gaaggcctta caggagtcag ggattgccta tgatcctgat gatgttgtct ggtttcatac
    22741 agaggacagg aaagtaaaac ctgcactgat ggcaaaagaa atggtacaga gcggacagct
    22801 tccggatgga atcgtctgtt acaatgatca gattgctgtt caggttatgg aagaactgga
    22861 gaaaatggga gtcaggatac cggatgatat ttccattacc ggttatgaca attcactgta
    22921 tgctcagcga ggaagcggaa tcacaacgat agctcatccg caggaaaagc tgggagaaat
    22981 ggcagcagag cttatacttg agaagatcaa cggagttcct gaagaagaaa gtaaggttga
    23041 aagactgatt tatccggaac tgatcatacg gggatcatgc agaaaaatat tgtaaacaaa
    23101 tgaaataaat aaaaaataaa aataaatccg ggaggaattt tatcatgaaa acaggaagaa
    23161 actataagtt ctggttttgt acaggttcac aggatcttta cggagatgag tgcttaagaa
    23221 aagttgctga gcattccaga atcattgtt
//
