LOCUS       c00099_gnlPro..        10260 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HFLFJKGA_99.
ACCESSION   c00099_gnlPro..
VERSION     c00099_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 23:36:21
            Original ID  :: gnl|Prokka|HFLFJKGA_99
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10260
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10260
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[7254:10198]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      7255..10198
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..10260
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10260
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             562..1410
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP_bind_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg99_1"
                     /sec_met_domain="ATP_bind_3 (E-value: 5.1e-08, bitscore:
                     21.6, seeds: 28, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKLEYLKEYLKGLGSVAVAFSSGVDSTFLLKVAHDVLGDKAIA
                     ITAQSCSFPKRELNEAKAFCEKEGIQHVICQSEELEIEGFSKNPPNRCYLCKKELFEKI
                     GDIAKKNGIEYIAEGSNMDDNGDYRPGLIAVKELGVKSPLREAKLTKAEIREYSKELGL
                     PTWDKQSFACLSSRFVYGETISEEKLGMVEKAEQLLLDYGFHQVRVRIHGSLARIETMP
                     EEFPKLLEKNVREDIAKKFKEYGFTYVTMDILGYRMGSMNETLGENDKTTADSSLRGKN
                     E"
     CDS             1407..3194
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M24"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg99_2"
                     /sec_met_domain="Peptidase_M24 (E-value: 3.2e-43, bitscore:
                     136.5, seeds: 437, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVKERITALRARMKETGIDAYLIPTDDFHGSEYVGEYFKCRKYI
                     TGFTGSAGTAVIMQDMAGLWTDGRYFIQAADQLEGTGITLFKMGEPEVPTVHEFLKKNL
                     TQGRCLGFDGRTVSAKEAAELEKMLDENGVSLSVDHDLAGDIWENRPVLSCEPVTELDI
                     KWAGESRADKCARIRKAMEKKGADLFVLTSLDDIAWLLNIRGGDIHCCPVVLSYLVMTK
                     TEIRLFANEKAFQTDVLEALEKDGVTLFPYDSIYEYVKTFKKDKKVLLCKKKVNSRLVS
                     NIPADTRILDEENLTLLPKATKNPVEVENERIAHIRDGVAVTKFIYWLKKNVGRIPITE
                     LSAAEKLYEFRSEQEDFIDNSFDPIIAYGKHAAIVHYFATPETDIPLEPSGFLLADTGG
                     HYKEGTTDITRTVVMGPTTEEEKKYFTAVLRGTLNLGAARFLHGCTGVNLDILARQPLW
                     EMGEDFKHGTGHGVGYLLNVHEGPNSFRWKIVPGGNAVLEEGMITSDEPGYYREDGFGI
                     RHENLMVCKKAEKTEYGQFMCFEFLTMVPFDLDGVVPELMSARERNLLNDYHAQVYEKI
                     SPYLNEEEKEWLKDATRAI"
     CDS             complement(3282..5048)
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     286.7; E-value: 2.2e-87)"
                     /gene_kind="resistance"
                     /locus_tag="ctg99_3"
                     /transl_table=11
                     /translation="MSRSAIKDPAKSKSSETFFKVLRFIGRYRFLLILSIILAAVSVIL
                     QLYVPILFGNAIDQVIAQHQVNFEMMWYYLSRILVMVILSSAATWLMNVINNRMTYQTV
                     KDIRAKAIRHIQVLPLSYLDGHSTGDIISRIIADTDILSDGMLLGFTQLFSGIVTIIGT
                     LIFMFSKNFWITLMVIVLTPVSFLVAKFISSHTFQMFRKQSDARGRQTALIEEMIGNQK
                     VVQAFGYEEKSSERFAKVNEELQECSLKAVFYSSLTNPSTRFVNNVIYACVALVGAFII
                     PGGRLTVGGLSVLLSYANQYMKPFNDISSVVTELQNALACAGRIFDLLEEEPEVAEASE
                     TLKDVKGEVDIKNVCFHYDESKKLIEDFNLHVKPGMRVAIVGPTGCGKSTFINLLMRFY
                     DVNSGSISVDGKPIRDITRHSLRSSYGMVLQETWIKNGTVRDNISIGKPEATDTEIIEA
                     AKLTHSWEFIRRLPKGLDTMLNEDSLSQGQKQLLCITRVMLCLPPMLILDEATSSIDTR
                     TELQIQEAFERMMEGRTSFIVAHRLSTIRNADLILVMKDGSIIEQGTHDELIAKGGFYH
                     TLYNSQFAKVSE"
     CDS             complement(5045..6859)
                     /locus_tag="ctg99_4"
                     /transl_table=11
                     /translation="MRSLAVYLKNYKKESILAPFFKFLEVVFDLIVPIVIAQIIDVGIS
                     NHDNKYIVQRFFILILMAALGLASSITAQFFAAKASVGFATKLRQAVYDHVQHLSFTEL
                     DTLGTDTLITRLTDDINQVQNGLNMGLRLLLRSPFIVLGSMVMAFTIDFKCALVFAVAI
                     PFLFLVVFVIMFLSIPLFKKVQGKLDTVTRLTRENLTGVRVIRAFCREKEAVAEFDTSN
                     QELTKLNLFVGKLSALLNPVTYVLINIATVILIQKAGVEVNLGGMQQGQVVALYNYMAQ
                     MIVELIKLASLIITLNKSAACAGRVADILKVKSTMDYPSFSTYSAQISKDLATATADAS
                     LSENAIVFNDVTFEYSKAGAPSLSHISFSVKKGQTVGIIGGTGSGKTTLVNLISRFYDA
                     SKGTVLLDGQNIENYTRSDLRSRIGVVPQKAALFKGSIRDNLKWGREDASDEDLWQALT
                     TAQGKEVVEGKPGQLDFMLEQNGKNLSGGQKQRLTIARALVKKPEILILDDSASALDFA
                     TDAALRKSLNRLDWKVTTFLVSQRSSSIQQADLILVLDNGTLAGKGTHAELLRTCDTYR
                     EIYFSQFPEERARYSSVSAGNIMKEVTV"
     CDS             7255..8526
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg99_5"
                     /sec_met_domain="HGD-D (E-value: 1.4e-56, bitscore: 181.2,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIIETFGHYVENLTDKKPQSARRLLKTGWEAQNLKFRYMQDKRL
                     MPADRHLANLMMDTMLRPIQKPEDSVIVSIFTPCEMMQEVGLHPYNVEGFSCYLSASKA
                     ERAFLQQAENQGIAETLCSYHKTFLGAAQKGLLPKPKCIVYTNLTCDANLLTFRTLADF
                     YQVPVFAIDVPWNQTTENVQYVADQLKDLKIFLEKNTGKTISEDRLKERLACSKRTLEN
                     YKKYQQMRADRYVPSDLVTPLYAGMTNNILLGTAEEEKYTQMLLEDIKKAPAAKGKHIY
                     WMHTIPFWSDAVRQELCFSEKAQIVGCELAETCEPDFDPENPFEAMAERMVYHSLNGSA
                     LRRIEAGIRHAKQAGADGAVWFGHWGCKHTLGAAQLAKKKFEEAGLPLLILDGDGCDRS
                     HGGEGQTSTRLGAFLEMLGGAENE"
     CDS             8519..10198
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg99_6"
                     /sec_met_domain="HGD-D (E-value: 8.1e-18, bitscore: 53.8,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 5.6e-66, bitscore:
                     211.4, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTYYVCKYTPIELLESLGGECENFNHMPEGFDLADQVSHPNIC
                     GFGKTLLEGVMEGKIKELVLVSCCDTIRSVYDILLESGKLDFLYILDVLHCDSACSRER
                     MAVQLKGLAKAYAQYKGTEFDAGKFRAAFHAQEKITKSHIAVLGARMGQELFEMTSKAM
                     PLPVENDTCVHNRSVGNILPPEGASFDELMDWYAGEILGQIPCMRMMDPTGRKKLYNDP
                     SVAGIIYHTVKFCDFYSFEYAEIKNHTDVPLLKIESDYTIQSSGQLLTRLEAFAESIQP
                     ETLEQTIDGDTKGERKMGKGYFAGIDSGSTSTDVVILNKDHEIVTSIILPTGAGAAIGA
                     DRALAEALKEAGLQREDIDALVTTGYGRTAIKNGDKSITEITCHARGAHFLNPEVRTVI
                     DIGGQDSKVIRLDENGAVANFVMNDKCAAGTGRFLEMMARTMEMNLDQMSECGLEFKED
                     ITISSMCTVFAESEVVSLIAQNKATDDIVHGLNKAVAVKTAALTRRVGGEEKYMMTGGV
                     SKNKGLVKTLEEKLGTKLVISDKAQLCGALGAALFAADMADV"
ORIGIN
        1 gtcagagaac atttaaccga gtatttaaag aaagatataa aatatcaccg agtgactacc
       61 ggagtacatg tctgaaagat atgttgtcat aacatataga ttaataaatt caataaaaat
      121 ctgattatca gtctgaaata agtatctctg ggtgttattt ataatatggg gtagtggtta
      181 attattatgt catgtatgaa tggggaagaa acaaacggag aactgcttca gaaaaagaag
      241 tagacaaact gtaaataaag aagttaagag aggctgttac tttagaaact atttaaagaa
      301 gtaacagaag tcggggaagc gttagaaaag atacaagaaa cataaatcaa tattgttcgt
      361 tctattttca gtaacacatt tcgcaatgcg aaaaataggt tgctgaacag tcattgccta
      421 tattataatg aagctatagc accctgttaa ataatacatt tgagaaagtt caactttcac
      481 gctctgttga gccagatcaa tatacattat ttacgaggag tgctacaggt acaataaaaa
      541 acggacaaga ggcagactga tatggaaaat aaactggaat atttaaaaga atatctgaag
      601 ggacttggca gtgtagcagt tgctttctca agtggagtgg attctacatt cttattaaaa
      661 gtagctcatg atgtgctggg tgataaggcg attgcgatta cggctcaatc ctgttctttc
      721 ccgaaaagag agctgaatga agcgaaggca ttctgcgaga aagaggggat tcagcatgtg
      781 atctgccagt ctgaggaatt ggagattgaa ggattttcaa agaatcctcc gaacagatgt
      841 tatttatgta aaaaagaact gtttgagaag attggcgata ttgcaaaaaa gaatgggatt
      901 gaatatattg cagagggatc aaatatggat gataacggcg attacagacc aggtctgatc
      961 gccgtaaaag aacttggagt taagagcccg ctacgtgagg cgaagctgac gaaagcggag
     1021 atcagagaat actcaaagga actggggctt ccgacttggg acaaacagtc atttgcctgt
     1081 ctgtcctcca ggtttgtcta tggagagacc atcagtgagg aaaagcttgg aatggttgag
     1141 aaagcagagc agcttttact tgactatgga ttccatcagg tacgtgtccg tattcacggt
     1201 tcacttgcaa gaattgagac tatgccggag gaatttccga aacttctgga aaaaaatgtc
     1261 cgagaggata ttgcaaagaa atttaaggag tatggattca cttatgtgac catggatatt
     1321 ctgggatatc gtatgggaag tatgaacgaa acacttggcg aaaatgacaa aacgactgca
     1381 gatagcagcc ttaggggtaa aaacgaatga cagtaaaaga gagaataaca gcacttcgtg
     1441 cacgcatgaa agagacagga attgatgcat atctgatccc tacagatgat ttccatggtt
     1501 cggaatatgt aggtgaatat ttcaaatgca gaaaatatat cacaggattt accggttctg
     1561 caggcactgc ggtgatcatg caggatatgg caggattatg gacggatgga cgttatttta
     1621 tccaggctgc agatcagctg gagggaacag gaattacttt atttaaaatg ggtgaaccgg
     1681 aagttcccac agttcatgaa tttctgaaaa aaaatctgac acagggaagg tgtctgggat
     1741 ttgacggacg tactgtcagt gcaaaagagg cagcagaatt ggagaaaatg ctggatgaaa
     1801 acggtgtgtc tctcagtgtt gatcacgatc tggcaggcga tatatgggaa aaccgtccgg
     1861 tactttcctg tgaaccggtt acagagctgg atataaaatg ggcaggagaa tccagagctg
     1921 ataaatgcgc aagaatccgc aaagcaatgg agaagaaggg tgcagattta tttgtactga
     1981 cttctctgga tgatattgcc tggctgttaa atatacgtgg gggagatatc cactgttgtc
     2041 cggtggttct ttcttatctt gtaatgacaa aaacagagat cagacttttt gcaaatgaga
     2101 aagcctttca gacagacgta ctggaagcgc tggaaaaaga tggtgtgacc ctttttccct
     2161 atgacagtat ctatgagtat gtgaaaacat ttaaaaagga caaaaaagtt cttctctgca
     2221 aaaagaaagt caacagtcgt ctggttagca atattccagc agacacccgg attctggatg
     2281 aagaaaatct tacacttctt cccaaggcaa cgaagaatcc tgttgaggtg gaaaatgaac
     2341 gcattgcgca tatcagagac ggagttgcag ttacaaagtt catatactgg ttaaagaaga
     2401 atgttggaag gattccgatc acagaattaa gtgcagcaga aaagctgtat gaattccgtt
     2461 cggaacagga ggatttcata gataacagtt ttgatccgat tattgcctat ggaaagcatg
     2521 ctgctattgt acattatttt gcaacacccg aaacggatat tcctctggaa ccatccggct
     2581 ttcttctggc agatacagga ggacattata aagagggaac cactgatatt acccgtactg
     2641 ttgtcatggg accgactact gaggaagaga aaaagtactt cacagcagtt ttgcggggaa
     2701 ctctgaatct gggagctgcc agatttcttc atggctgtac cggtgtaaat ctggatattc
     2761 tggcgagaca gccgttgtgg gaaatgggag aggattttaa acatggaacc ggtcatggag
     2821 taggatatct tctgaatgtc catgaaggac ccaatagctt ccgatggaaa attgttccgg
     2881 gtggaaatgc agtgctggag gagggaatga tcacctctga tgagccggga tattacagag
     2941 aggatggatt tggaatccgt catgaaaatc tgatggtctg caaaaaagct gaaaaaacag
     3001 agtatggtca gtttatgtgt tttgaatttc taactatggt accttttgat ctggatggag
     3061 tggtgccgga actgatgagt gcccgggaac gtaaccttct caatgattac catgcacagg
     3121 tatatgagaa gatttctccg tatttgaacg aagaagaaaa agaatggctg aaagatgcta
     3181 cccgagcaat ctgataaaaa taaaaaaaca ttttacaaaa tcaaaaagag gaacagccgt
     3241 gatggacagc tgttcctttt tgatttatta tctggcttgt tttattcaga aacttttgca
     3301 aactggctgt tatataaagt atggtaaaat ccaccttttg caatcagctc atcatgagta
     3361 ccctgctcaa tgatacttcc gtctttcata acaagaatca gatctgcatt tcggatggtt
     3421 gaaagcctgt gagctacgat aaagcttgtt cttccctcca tcattcgttc aaacgcttcc
     3481 tgaatttgta attctgttcg tgtatcaata ctggaagtgg cttcatccag gatcagcatc
     3541 ggaggcagac agagcataac tcgtgtgata cacagcagct gtttctgtcc ctggcttaag
     3601 ctgtcttcgt tgagcatggt gtccagtcct ttaggaagcc tccggataaa ttcccagctg
     3661 tgggtaagct tggctgcttc gatgatttca gtatctgtag cttccggttt tccaatcgag
     3721 atattgtcgc ggacagttcc gtttttgatc catgtttcct gaagcaccat accatagctg
     3781 cttctgagag aatggcgggt aatgtctctg atcggtttgc cgtcaacgga aatagatccg
     3841 gaatttacat catagaatct catcagaagg ttgataaagg ttgacttacc gcatccggta
     3901 ggtcctacaa tggcaacgcg catacctggt tttacatgga gattaaagtc ctcaatcagt
     3961 ttctttgatt catcataatg gaagcacaca ttcttaatat ctacttcacc ctttacatct
     4021 ttcagtgtct cagaagcctc tgcaacttcc ggttcctcct ccagcagatc gaagattctg
     4081 cctgcacagg caagagcatt ctgaagttct gtaacaacgg aactgatatc attgaatggt
     4141 ttcatatact ggttggcata ggagagaagt acggaaagtc ctccgactgt cagtctgcct
     4201 ccagggataa tgaatgcacc caccagtgca acacaggcat aaataacatt attgacaaaa
     4261 cgggtggaag ggtttgtcag gctgctgtaa aaaacagcct tcagactgca ttcctgtaat
     4321 tcttcgttaa cctttgcaaa gcgttcagaa gatttttcct catatccaaa agcctgaaca
     4381 accttctggt ttccaatcat ctcttcgatg agagcagtct gacgtcctct ggcatcgctt
     4441 tgcttccgga acatctggaa ggtatgggaa gaaataaatt tggccaccaa aaagcttacg
     4501 ggggtcagga caatgaccat taatgtaatc cagaagtttt tggagaacat gaagatcagt
     4561 gttccgatga tcgttacgat tccggaaaaa agctgggtaa atccaagcag cataccatcg
     4621 gatagaatat ctgtatctgc gataatacgg ctgatgatat ctccggtact gtgtccgtca
     4681 aggtaagaga ggggaagtac ctgaatgtgt cggatggctt tggcacggat atcctttact
     4741 gtctggtagg tcatgcggtt attgatcaca ttcataagcc acgtggcagc agaagagagg
     4801 atgaccatta caaggatacg tgacaggtaa taccacatca tttcgaagtt tacctgatgt
     4861 tgggcaatga cctgatcaat ggcatttccg aataggattg ggacatacag ctgaaggata
     4921 acggaaactg ctgccagtat gatactgagg atcagcagaa aacggtatct tccgatgaaa
     4981 cgcagtactt taaaaaaagt ttcgctgctt ttgcttttag caggatcttt tattgctgat
     5041 ctgctcatac agtcacctcc ttcattatat tacctgcaga tacagaggag tatctggctc
     5101 tttcttccgg aaactgagag aagtagattt cccggtaagt atcacaggta cgcagcagtt
     5161 cagcatgagt acccttacct gccagagtac cgttatcaag gacaaggatc aggtctgcct
     5221 gctgaatgct ggaggaacgc tgggatacca gaaatgtagt tactttccag tcaagtctgt
     5281 tgagagactt acgcagtgct gcatcagtgg caaagtccag ggcactggca ctgtcatcca
     5341 ggatcaggat ttcaggtttt tttaccaggg cacgggcaat ggtaagtctt tgtttctggc
     5401 cgccggaaag gtttttaccg ttctgttcca gcataaaatc aagctgtccc ggtttaccct
     5461 ctactacctc ttttccctgt gctgtggtaa gtgcctgcca cagatcctcg tcagaggcat
     5521 cttcccggcc ccatttcaga ttgtcccgga tagaaccttt gaaaagagct gccttctgag
     5581 gaacaacgcc gattctggag cggagatcac ttctggtgta attttcaata ttctgaccat
     5641 ccagcagaac agttcctttg ctggcatcat agaatctgga gatcagattt accagagtgg
     5701 tttttccgct tcctgtacca ccgataatac ctacggtctg tccctttttt acagaaaaac
     5761 tgatatgaga aagactgggg gcaccggctt tgctgtactc aaaggttacg tcattgaata
     5821 cgatggcatt ttcagaaagt gatgcatcag cagttgctgt tgcaaggtcc ttcgatatct
     5881 gagcagaata tgtggagaaa gaagggtaat ccatagtaga tttcactttc aggatatctg
     5941 ccacacgtcc tgcgcaggct gcagatttgt tcagggtgat gatcagggag gcaagcttga
     6001 tcagttccac gatcatctga gccatatagt tataaagggc aacaacctgt ccctgctgca
     6061 taccgccaag atttacttct actcctgctt tctggatcag aataacagta gcaatattga
     6121 tcagtacgta agtgaccgga tttaacaaag cggaaagctt tcctacaaag agatttaact
     6181 ttgtcagctc ctgattgctg gtatcaaatt ctgcaactgc ctctttttcg cggcagaatg
     6241 cacggataac gcggacgcct gtaaggtttt ctctggtcag tctggttact gtgtccagtt
     6301 ttccctgtac ttttttaaac agaggaatac tgagaaacat aatgacaaag acaaccagaa
     6361 acagaaacgg gattgcaaca gcaaaaacca gggcacattt aaagtcaatg gtaaatgcca
     6421 tgaccatgga cccaagtacg ataaacggac ttcgaagaag aagacgaagc cccatgttca
     6481 gtccgttctg gacctgattg atatcgtcgg taagtcttgt gatcagggtg tctgttccca
     6541 gggtatccag ctctgtaaaa gacagatgct gtacatggtc ataaacggcc tgtcttaatt
     6601 tagtggcaaa gcccacgctg gctttggctg caaagaactg agctgtaatg ctgctggcaa
     6661 gaccaagagc tgccattaaa ataagaataa aaaatctctg gacaatgtat ttgttgtcat
     6721 ggtttgaaat acctacatca atgatctgtg caatgacgat aggcacgatc aggtcaaata
     6781 caacctccag aaatttaaaa aatggcgcca ggatgctttc ttttttgtag ttttttaaat
     6841 aaactgccaa tgaacgcatt ttaaaaattc cttcctttcg taaaaaatct ttcctatatt
     6901 atttcttcct ttttttgaaa aataatacat tcaaaagtgt atcatttaag acttttttgt
     6961 caagaagaat gtgcaaaaac agatgaactt tggagaaaat tcgttactgt tcactccgtt
     7021 cacagtaact tagccaaaat tcattccaga ttgcctgcgg caatggaatt ttggcttgta
     7081 tgtctcggga ttttggcata ttcatgccaa aacacctcgc agaatagtgg tgtgtgaaca
     7141 gtaacgaaaa ttcaacttga cttccaaaaa agatattatt aaaatattcc gtggcactat
     7201 ttgtgcgttg acaatagata aattattatt accataatga ggaagagaca gactatggag
     7261 attattgaga catttggtca ttatgtggaa aatctgacgg ataaaaagcc tcagtcagcc
     7321 cgccggctgt taaaaaccgg ctgggaggcg cagaatctga agttccgtta catgcaggac
     7381 aagagactga tgcctgcaga caggcatctt gcaaatctga tgatggatac catgttgcgg
     7441 cccattcaga aaccggaaga ttctgttatt gtaagtattt ttacaccctg cgaaatgatg
     7501 caggaggtgg gattacatcc ctataatgta gaaggatttt cctgctatct ttctgcaagc
     7561 aaagcagaga gggcattttt gcagcaggca gagaatcagg gaattgcaga gacactgtgc
     7621 agttatcaca agacatttct tggtgcagcg cagaaaggac ttctgccaaa gcccaaatgt
     7681 attgtttata ccaacctgac ctgcgatgct aacctgctca ccttccgtac cctggcagat
     7741 ttttaccagg tacctgtatt tgccattgat gtaccatgga atcagaccac agagaatgta
     7801 cagtatgtgg cagatcagtt aaaggattta aaaatatttc tggaaaaaaa tacaggaaaa
     7861 acaatctctg aggacagatt aaaggaacgt cttgcctgca gtaagcggac tctggagaat
     7921 tacaaaaaat atcagcagat gcgtgcagac agatatgtgc cctctgatct ggtcacaccc
     7981 ttgtatgcag gaatgacaaa caatatcctt ctgggaacag cagaagaaga gaagtataca
     8041 cagatgcttc ttgaagatat taagaaagca ccggcagcga aagggaagca catttattgg
     8101 atgcatacca ttccattctg gtcggatgca gtgcgccagg agctttgctt cagtgagaaa
     8161 gcccagatcg taggatgtga acttgcagaa acctgtgagc cggattttga tcctgagaac
     8221 ccctttgaag caatggcaga aagaatggta tatcattcac tgaacggaag tgcccttaga
     8281 aggattgaag ccggtatccg ccatgcgaaa caggcaggag cagacggtgc tgtgtggttt
     8341 ggacattggg gatgtaaaca tacgcttggt gcggcacagc ttgcaaagaa gaagttcgag
     8401 gaagccggtc tgcccctttt gatcctggac ggtgacgggt gtgatcgaag ccatggagga
     8461 gaaggacaga cttccaccag gctgggagct tttctggaaa tgctgggagg tgctgagaat
     8521 gaataaaact tactatgtct gtaaatatac cccaattgaa cttctggaat ctcttggcgg
     8581 ggaatgtgag aactttaatc atatgccgga gggatttgac ctggccgatc aggtttcaca
     8641 tcccaatatc tgcggttttg gaaaaacact tctggaagga gtcatggagg ggaaaatcaa
     8701 ggaacttgtc ctggtgagct gctgtgatac tatcaggagt gtctatgaca ttctgctgga
     8761 aagcggcaag ctggattttc tctatatttt ggatgtgctt cactgtgaca gtgcctgcag
     8821 cagagagcgt atggctgtac agttaaaagg gctggcgaag gcttatgcac agtacaaagg
     8881 cacagagttt gatgccggaa aattccgggc tgctttccat gcacaggaga aaatcacaaa
     8941 gtcccatatt gcagtgcttg gcgccagaat ggggcaggaa ttatttgaaa tgaccagcaa
     9001 agctatgcct cttcctgtag agaatgatac ctgcgtgcat aaccgttctg tgggaaatat
     9061 acttccaccg gagggtgctt cttttgatga gctgatggac tggtatgcag gtgagattct
     9121 ggggcagatt ccatgtatgc gtatgatgga cccgacaggt cgtaagaagc tttataatga
     9181 tccgtctgtt gcggggatta tttatcatac agtgaagttt tgtgattttt acagcttcga
     9241 atatgctgaa atcaagaatc atacagatgt acctctttta aaaatcgaat cagattatac
     9301 tattcagagc agcggtcagc ttcttaccag actggaagct tttgcagaga gcattcagcc
     9361 tgaaacactg gagcagacca tagatggaga cacaaaagga gagagaaaaa tgggaaaagg
     9421 ttatttcgca gggattgaca gtggttccac cagtacagat gtggtgattt taaataaaga
     9481 tcatgagatt gtgaccagca ttatcctgcc tacaggagca ggagctgcta tcggagcaga
     9541 ccgtgccctt gcagaagcat tgaaggaggc cggattgcag agagaagata ttgatgcgct
     9601 ggttactacc ggatacggac gtacagctat taaaaatggt gataagagta tcacagagat
     9661 cacctgtcat gcaagaggtg cgcatttcct gaatccggaa gtccgtactg ttattgatat
     9721 tggcggacag gacagcaagg tgatccgact ggatgagaac ggtgcagttg caaactttgt
     9781 tatgaatgac aaatgtgcgg caggaaccgg acgatttctg gaaatgatgg cacgtaccat
     9841 ggaaatgaat ctggatcaga tgagcgaatg tgggctggaa ttcaaagaag atattacaat
     9901 ttccagtatg tgtacagtat ttgcagaatc agaagttgta tccctgatcg cccagaataa
     9961 ggcaacagat gatattgtcc atggcttgaa taaggcggtt gccgtaaaga ctgccgccct
    10021 taccagacgt gtgggcggtg aggagaaata tatgatgacc ggtggtgttt ctaagaataa
    10081 aggcctggta aagacactgg aagagaagct tggaacaaag ctggtgatca gtgacaaggc
    10141 tcagctttgc ggtgcacttg gcgcagcact gtttgcggct gatatggctg atgtgtaaat
    10201 ttttagttac tgttcactcc gttctcagca acacgcttcg cgatgcagga aatatgaacc
//
