GCA_958422375.1 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaOEADKHHE_15 (original name was: gnl|Prokka|OEADKHHE_15)

Region	Type	From	To	Most similar known cluster		Similarity
Region 15.1	ranthipeptide	2,439	24,027

gnlProkkaOEADKHHE_19 (original name was: gnl|Prokka|OEADKHHE_19)

Region	Type	From	To	Most similar known cluster		Similarity
Region 19.1	NRPS	1	32,256	dipeptide aldehydes	NRP	29%

gnlProkkaOEADKHHE_20 (original name was: gnl|Prokka|OEADKHHE_20)

Region	Type	From	To	Most similar known cluster		Similarity
Region 20.1	lanthipeptide-class-ii	1	21,188

gnlProkkaOEADKHHE_23 (original name was: gnl|Prokka|OEADKHHE_23)

Region	Type	From	To	Most similar known cluster		Similarity
Region 23.1	cyclic-lactone-autoinducer	1	15,425

Region	Type	From	To	Most similar known cluster	Similarity
Region 15.1	ranthipeptide	2,439	24,027
Region 19.1	NRPS	1	32,256	dipeptide aldehydes	NRP	29%
Region 20.1	lanthipeptide-class-ii	1	21,188
Region 23.1	cyclic-lactone-autoinducer	1	15,425

No secondary metabolite regions were found in these records:: gnlProkkaOEADKHHE_1 (original name was: gnl|Prokka|OEADKHHE_1); gnlProkkaOEADKHHE_2 (original name was: gnl|Prokka|OEADKHHE_2); gnlProkkaOEADKHHE_3 (original name was: gnl|Prokka|OEADKHHE_3); gnlProkkaOEADKHHE_4 (original name was: gnl|Prokka|OEADKHHE_4); gnlProkkaOEADKHHE_5 (original name was: gnl|Prokka|OEADKHHE_5); gnlProkkaOEADKHHE_6 (original name was: gnl|Prokka|OEADKHHE_6); gnlProkkaOEADKHHE_7 (original name was: gnl|Prokka|OEADKHHE_7); gnlProkkaOEADKHHE_8 (original name was: gnl|Prokka|OEADKHHE_8); gnlProkkaOEADKHHE_9 (original name was: gnl|Prokka|OEADKHHE_9); gnlProkkaOEADKHHE_10 (original name was: gnl|Prokka|OEADKHHE_10); gnlProkkaOEADKHHE_11 (original name was: gnl|Prokka|OEADKHHE_11); gnlProkkaOEADKHHE_12 (original name was: gnl|Prokka|OEADKHHE_12); gnlProkkaOEADKHHE_13 (original name was: gnl|Prokka|OEADKHHE_13); gnlProkkaOEADKHHE_14 (original name was: gnl|Prokka|OEADKHHE_14); gnlProkkaOEADKHHE_16 (original name was: gnl|Prokka|OEADKHHE_16); gnlProkkaOEADKHHE_17 (original name was: gnl|Prokka|OEADKHHE_17); gnlProkkaOEADKHHE_18 (original name was: gnl|Prokka|OEADKHHE_18); gnlProkkaOEADKHHE_21 (original name was: gnl|Prokka|OEADKHHE_21); gnlProkkaOEADKHHE_22 (original name was: gnl|Prokka|OEADKHHE_22); gnlProkkaOEADKHHE_24 (original name was: gnl|Prokka|OEADKHHE_24); gnlProkkaOEADKHHE_25 (original name was: gnl|Prokka|OEADKHHE_25); gnlProkkaOEADKHHE_26 (original name was: gnl|Prokka|OEADKHHE_26); gnlProkkaOEADKHHE_27 (original name was: gnl|Prokka|OEADKHHE_27); gnlProkkaOEADKHHE_28 (original name was: gnl|Prokka|OEADKHHE_28); gnlProkkaOEADKHHE_29 (original name was: gnl|Prokka|OEADKHHE_29); gnlProkkaOEADKHHE_30 (original name was: gnl|Prokka|OEADKHHE_30); gnlProkkaOEADKHHE_31 (original name was: gnl|Prokka|OEADKHHE_31); gnlProkkaOEADKHHE_32 (original name was: gnl|Prokka|OEADKHHE_32); gnlProkkaOEADKHHE_33 (original name was: gnl|Prokka|OEADKHHE_33); gnlProkkaOEADKHHE_34 (original name was: gnl|Prokka|OEADKHHE_34); gnlProkkaOEADKHHE_35 (original name was: gnl|Prokka|OEADKHHE_35); gnlProkkaOEADKHHE_36 (original name was: gnl|Prokka|OEADKHHE_36); gnlProkkaOEADKHHE_37 (original name was: gnl|Prokka|OEADKHHE_37); gnlProkkaOEADKHHE_38 (original name was: gnl|Prokka|OEADKHHE_38); gnlProkkaOEADKHHE_39 (original name was: gnl|Prokka|OEADKHHE_39); gnlProkkaOEADKHHE_40 (original name was: gnl|Prokka|OEADKHHE_40); gnlProkkaOEADKHHE_41 (original name was: gnl|Prokka|OEADKHHE_41); gnlProkkaOEADKHHE_42 (original name was: gnl|Prokka|OEADKHHE_42); gnlProkkaOEADKHHE_43 (original name was: gnl|Prokka|OEADKHHE_43); gnlProkkaOEADKHHE_44 (original name was: gnl|Prokka|OEADKHHE_44); gnlProkkaOEADKHHE_45 (original name was: gnl|Prokka|OEADKHHE_45); gnlProkkaOEADKHHE_46 (original name was: gnl|Prokka|OEADKHHE_46); gnlProkkaOEADKHHE_47 (original name was: gnl|Prokka|OEADKHHE_47); gnlProkkaOEADKHHE_48 (original name was: gnl|Prokka|OEADKHHE_48); gnlProkkaOEADKHHE_49 (original name was: gnl|Prokka|OEADKHHE_49); gnlProkkaOEADKHHE_50 (original name was: gnl|Prokka|OEADKHHE_50); gnlProkkaOEADKHHE_51 (original name was: gnl|Prokka|OEADKHHE_51); gnlProkkaOEADKHHE_52 (original name was: gnl|Prokka|OEADKHHE_52); gnlProkkaOEADKHHE_53 (original name was: gnl|Prokka|OEADKHHE_53); gnlProkkaOEADKHHE_54 (original name was: gnl|Prokka|OEADKHHE_54); gnlProkkaOEADKHHE_55 (original name was: gnl|Prokka|OEADKHHE_55); gnlProkkaOEADKHHE_56 (original name was: gnl|Prokka|OEADKHHE_56); gnlProkkaOEADKHHE_57 (original name was: gnl|Prokka|OEADKHHE_57); gnlProkkaOEADKHHE_58 (original name was: gnl|Prokka|OEADKHHE_58); gnlProkkaOEADKHHE_59 (original name was: gnl|Prokka|OEADKHHE_59); gnlProkkaOEADKHHE_60 (original name was: gnl|Prokka|OEADKHHE_60); gnlProkkaOEADKHHE_61 (original name was: gnl|Prokka|OEADKHHE_61); gnlProkkaOEADKHHE_62 (original name was: gnl|Prokka|OEADKHHE_62); gnlProkkaOEADKHHE_63 (original name was: gnl|Prokka|OEADKHHE_63); gnlProkkaOEADKHHE_64 (original name was: gnl|Prokka|OEADKHHE_64); gnlProkkaOEADKHHE_65 (original name was: gnl|Prokka|OEADKHHE_65); gnlProkkaOEADKHHE_66 (original name was: gnl|Prokka|OEADKHHE_66); gnlProkkaOEADKHHE_67 (original name was: gnl|Prokka|OEADKHHE_67); gnlProkkaOEADKHHE_68 (original name was: gnl|Prokka|OEADKHHE_68); gnlProkkaOEADKHHE_69 (original name was: gnl|Prokka|OEADKHHE_69); gnlProkkaOEADKHHE_70 (original name was: gnl|Prokka|OEADKHHE_70); gnlProkkaOEADKHHE_71 (original name was: gnl|Prokka|OEADKHHE_71); gnlProkkaOEADKHHE_72 (original name was: gnl|Prokka|OEADKHHE_72); gnlProkkaOEADKHHE_73 (original name was: gnl|Prokka|OEADKHHE_73); gnlProkkaOEADKHHE_74 (original name was: gnl|Prokka|OEADKHHE_74)

Compact view

gnlProkkaOEADKHHE_15 - Region 1 - ranthipeptide

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Location: 2,439 - 24,027 nt. (total: 21,589 nt) Show pHMM detection rules used

Region on contig edge.

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

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core biosynthetic genes

additional biosynthetic genes

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KnownClusterBlast

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaOEADKHHE_19 - Region 1 - NRPS

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Location: 1 - 32,256 nt. (total: 32,256 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

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transport-related genes

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resistance

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NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

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Similar known gene clusters from MIBiG 3.1

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 32256:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg19_3

AMP-binding (20..419): X

nrpys: Leu, Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVLTDGGISK
Nearest Stachelhaus code(s):: Leu or Trp DVLTDGGISK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1033..1421): X

nrpys: Leu, Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAMFSGAIFK
Nearest Stachelhaus code(s):: Leu or Trp DAMFSGAIFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2027..2418): X

nrpys: Leu, Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAITTGGVSK
Nearest Stachelhaus code(s):: Leu or Trp DAITTGGVSK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaOEADKHHE_20 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 21,188 nt. (total: 21,188 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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core biosynthetic genes

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KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

Lanthipeptide predictions

Lanthipeptide(s) for ctg20_9

allorf_00016_00201

Leader:

MSLNFSTYAYITKSPVRYSDAAVFSA

Core:

AAPDYHHPELFPVLLLFHTRELYPHMTEVTCFQTL

Core with dehydrations:

AAPDYHHPELFPVLLLFHDhbRELYPHMDhbEVDhbCysFQDhbL

antiSMASH-DB 4.0 matches for allorf_00016_00201

14.3% NZ_CP058552.1: Lanthipeptides: allorf_1481579_1481740_lanthipeptide

23

YPHMTEVTCFQTL

35

Y H+ + C QT+

6

YKHVQKTNCVQTI

18

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

allorf_00016_00201 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 4093.1 Da

Molecular weight: 4095.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4113.7 Da N = 1; 4131.7 Da N = 2; 4149.7 Da N = 3

gnlProkkaOEADKHHE_23 - Region 1 - cyclic-lactone-autoinducer

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Location: 1 - 15,425 nt. (total: 15,425 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.