LOCUS       c00019_gnlPro..        16598 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BFJJCLAD_19.
ACCESSION   c00019_gnlPro..
VERSION     c00019_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 23:38:55
            Original ID  :: gnl|Prokka|BFJJCLAD_19
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16598
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16598
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2355:6598]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2356..6598
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..16598
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16598
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(36..827)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CbiA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_1"
                     /sec_met_domain="CbiA (E-value: 3.5e-27, bitscore: 86.9,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VIKISKKATTIAIVNQKGGTGKTTTCENLGIGLAMEGKKVLLVDA
                     DPQGSLTISMGWQQPDELPTTLSTLMAKIMNDQPIQPGEGVLHHVEGVDLIPANIELAG
                     LEVSLVNCMNREKMLKQVLEGAKHEYDFILLDCTPSLGMLTVNALAAADTTLIPVQAQY
                     LSAKGLEQLLQTVQKVRRQINPKLKIEGILLTMTDSRTNYGQQIDNLIRGAYGSKIKVF
                     DQTIPRSVRAAEISAVGKSIFQHDPKGKVAEAYRSLTKTNY"
     CDS             complement(824..1693)
                     /locus_tag="ctg19_2"
                     /transl_table=11
                     /translation="MTLDYFYGQAGELFSFYRIPKALFQEPRFQNLSTDAKTLYGILLD
                     RMSLSAKNGWLDEQGRVFIIFTIEDVKRALCCADNKATKLLRELEKFGLIERKRRGLGK
                     PSLVYVKNFSAESSKSIFQNRDFHDSGGFKSASQDPAKSRCNKTDENNTEKSETYPFYS
                     EEADEMSKREQLKEYFSQSLEVELLLRLCPDDEDTIYQIVDLLVDTCATNRKTLRIAGD
                     DKPAEVVRSRFMKLNADHIRFVLKCLAENSSPIRNMKQYLLASLYNAPTTMQLSYQNQT
                     NHDLAMRR"
     CDS             complement(1690..1869)
                     /locus_tag="ctg19_3"
                     /transl_table=11
                     /translation="MFYPPFGTKQVEIFLFIKRKSAILIFKNRNCAFLFQKIYCEEVFY
                     NVNILPTLFQSTAT"
     CDS             complement(2356..3567)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_4"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 3.4e-14,
                     bitscore: 44.8, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVRDSRPPFAGLANLSEEQLHRLPTPCYLLDEAQLCRNGEILLG
                     VQQRTGCRILLAQKAFSNFNVYPVLAPYLAGTEASGLYESRLGREELPEKENHVFCAAY
                     RADEFEELLQYADHIVFNSPSQLAKFGPAAKAAGKSIGLRINPECSTQEGHEIYDPCAP
                     GSRLGTTRAQWDDAVAAHPELPALLDGLHFHTLCEQDADALAVTLAAVEKKFADLLPRM
                     KWLNFGGGHHITRPGYALGTLESCILSVRQKYGVQVYLEPGEAWALNAGYLVTTVLDTL
                     RNGDTSLAILDMSAACHTPDVIEMPYRPPLLDAGEAGEKAHTVRLGGPTCLAGDIIGDY
                     SFDAPLAEGDKLIFGDMAIYTTCKNNTFNGMPLPPIWLLGADGNCRELVHFGYQDFKMR
                     LGAQ"
     CDS             complement(3567..4826)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_5"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 1.5e-44, bitscore:
                     144.9, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 5.5e-33,
                     bitscore: 105.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVLIIGCGGVASVAIHKCCQVPEVFTEICIASRTKAKCDKLAA
                     ELAPTTTTKITTAQVDADKVEEVIALIKAYQPDLVMNIALPYQDLTIMDACLACGVNYM
                     DTANYEPENTDDPEWRAIYEKRCKEAGFSAYFDYSWQWAYAKKFEEAGLTALLGSGFDP
                     GVTQAYCAYAKKHEFDTIDTIDILDCNGGDHGYAFATNFNPEINLREVSAPGSYWENGH
                     WVEIPAMSIKREYNFDQVGDKDMYLLHHEEIESLAKNIPEAKRIRFFMTFGQSYLDHMR
                     CLEDVGMLSTTPVNFNGQEIVPIQFLKALLPDPASLGPRTKGKTNIGCIFTGKKDGKDK
                     TYYIYNVCDHQECYKEVGSQAISYTTGVPAMCGALMLLTGKWTTKGVHTVEEFDPDPYL
                     DALDKYGLPRSESHDPALVD"
     CDS             complement(4866..5741)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Arginase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_6"
                     /sec_met_domain="Arginase (E-value: 3.3e-77, bitscore:
                     251.5, seeds: 235, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPNVETFIGCDSSYRAASIVLYGAPYDSTTSYRPGARFGPAAIR
                     HESYGLETYSPYQNADLTDFDVFDSGDLELCFGSSELALADIEARAEEILKDGKFPLLL
                     GGEHLVTLGAVRAAVKKYPDLHIVHFDAHADLRDDYLGAKLSHACVLRRCHELVGDGHI
                     HQFCIRSGDRAEFEFAAQHTEMHKFDFTGLAELTAQLCESKVPVYLTIDLDCLDPSCFP
                     GTGTPEAGGVSFLQLLEAIRTVTKANIIGADLNELAPTLDTTGVSTATACKVLRETLIA
                     LDKGWPGFQV"
     CDS             complement(5741..6598)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_7"
                     /sec_met_domain="Spermine_synth (E-value: 3.3e-54,
                     bitscore: 175.0, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 1.3e-22,
                     bitscore: 71.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFWFSEFHTPDVKHSIRVNKQLYSKQSDYQRIDIFETPEFGRVL
                     TLDGNVMLTERDEFIYDEMIVHVPMAVHKEAKDILVIGAGDGGVVRELTRYDRVERIDL
                     VEMDPQVVEACRAYLPSNACRMDDRRVHIYFENALKYIRRCEEEYDLIIVDSSDPFGPS
                     EGLFTREFYGSCFNALKEDGIMVNQQGSPFYAEDASAMQRSHKRIASTFPISRVYQAHI
                     PTFAAGYWLFGFASKKYHPIDDLDAESWKALNMRTRYYTTKLHIGAFYLPAFLEEMLRE
                     VEEH"
     CDS             complement(6611..8077)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_8"
                     /sec_met_domain="OKR_DC_1_C (E-value: 1.9e-11, bitscore:
                     36.3, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 1.2e-122,
                     bitscore: 401.1, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNENKARSRLDQRRAPIYEALERFRQMRVVPFDVPGHKRGRGNPE
                     LTAFLGQQCVGVDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSSVQS
                     MVLTACKRGDEIILPRNVHRSVLNALVLCGAVPVYVNPEVDKRLGISLGMKREQVAKAI
                     KEHPNAVAVLVNNPTYYGICSDLRAIVKMAHDAGMLCLADEAHGTHFYFGGGLPVSAMA
                     AGADMASVSMHKSGGSLTQSSLLLIGPNVHPGYVRQIINLTQTTSGSYLLMSSLDISRR
                     NLALRGRQVFHQVADIAEYAREEINAVGGYYAFGKELCNGDSVFDFDTTKLSVHTLDIG
                     LAGIEVYDILRDEYDIQIEFGDIGNILAYLSIGDRPQEVERLVSALAEIKRRYRTDGSG
                     LLSQEYIDPVVAASPQEAFYAPKKSLPLRETEGMVCSEFVMCYPPGIPILAPGERITKE
                     ILNYIEYAKAKGCSMTGPEDPEILHLNVLA"
     CDS             8649..9392
                     /locus_tag="ctg19_9"
                     /transl_table=11
                     /translation="MEKEGVWMALPIAIVEDQTPDAQRLEELLQQQLPEAECTWFACGD
                     DFLRAAAEPGLYAVVFLDICMAGTNGIETARRLRQADPEVLIVFVTSSPEYVWDAFPVH
                     PFDYLLKPYQEEKFVHLAAELRRALRCKEPELEIRIARQSIQLSLRKVLYAIARNHYVL
                     ITTEDGEYRAMCSFAQIEEKLTARENFMSCNRGVIINMDKVLRFGEDCIEILDGTRLPV
                     RQKDKCTLLAHFTQYQFRHMRQELH"
     CDS             9410..10726
                     /locus_tag="ctg19_10"
                     /transl_table=11
                     /translation="MDLALFGRYFLDFALLYPSAFLCLASLWEKLRTPRRTACIAAGCI
                     TLLCIGCAALCAVFGLNSNSLLPAIVLVSFWLLRWRVTPEVTVSQTAFLFSISAVMMAV
                     CSLLSTLLNAQTEISNPQTVCLASTALLRLGLAAMLTVLFWFTAVQWSRWLLREYSGEA
                     FWQSAWPLPALYAVFLVYCMPLNPAVVLVGRLKIISVLAVSISLFGIFLLLYEMYRVAR
                     EFTRNARLDRENQLLAMESRRYMELQTYLDNTRRLRHDFRQHLHVIAGLTETGQLEELK
                     SYLHQYESELSEHRPSLCANAAVDALAGYYDHAAGQQSVPVEWKLALPRQLPMPEADLC
                     TILGNLLENALHASQKLPPEQRRVQVMAQMLSPAMLGLVVENRYDGMLKKQQGILRSTK
                     HEGTGIGLVSAETVVHKYNGNLHLETEEQIFRVNVLLNL"
     CDS             complement(10813..11052)
                     /locus_tag="ctg19_11"
                     /transl_table=11
                     /translation="MGFFAVLAASLFAVFIFTVFGGYSLLLWCQQSLWMVVPPALVLAV
                     LVWTFLKMDDKITALQKRVDELEAAQKSTEKLEK"
     CDS             complement(11072..11548)
                     /locus_tag="ctg19_12"
                     /transl_table=11
                     /translation="MIYDTLNNLPNYLGVSDNLDTVIEYIMARDITTLPAGRTRIDGDK
                     AVVTVSTVTPQTSDKALFQRHDNHITLETDLDGSELFEVSLAELTPTKPTDEAADTTVG
                     TAGTSIAGMLCEGRFALYLAGEPYKSGLKAQGCGKLKKAVFSIELDPDEEETEE"
     CDS             complement(11850..13373)
                     /locus_tag="ctg19_13"
                     /transl_table=11
                     /translation="MTAVIYARYSSDNQREESIEGQIRECTAYAEKNGITVVKHYIDRA
                     LSAKTDNRPDFQQMIKDSEKRLFDIVLVWKLDRFARNRYDSAHYEYQLERNHVKLVSAT
                     EPISDSPAGIMVKSMLTGMAEYYSAELSEKVVRGMTENVLKGKYNGGTIPIGFKVDEEK
                     FFQIDPLKAPFVVEAFQRYNDGATMKELMNWLNDSGVTTNRNQKFTYNSVQKLLTNKRY
                     IGENHFKDIVMPDSIPAIVDKDLFEEVQLKIKKNSRAPARHKAEDDYLLTTKLFCGMCG
                     AMMFGECGTGRNKVVHHYYKCATAKRFKTCKKKTVRKEWLEDLVVAETMKLIQDDAVID
                     AIVAEVMELQDQENTTLPLLEKQMREVENGIENMLNAIQAGVLTNSTKSRLEKLEAQQK
                     ELEVRIAEEKIARPQLSENQVRFWLTRFRKLDPNVKSHRETLINTFVNAVYLYDEKVLI
                     TFNYKDGTKTITFDEIAAKDAPEGNGSDLGCFAPPKSLSVCKCAEVFVL"
     CDS             complement(13387..13707)
                     /locus_tag="ctg19_14"
                     /transl_table=11
                     /translation="MKQYDVKISHAALSDMEQIYSYIADRLLEPDTAMGQYNRIAEAIQ
                     SLNILPERCALVESEPERTQGLRQMLVDNYSVFYIVGEDVVSVARVLYSASDLVRRLRR
                     MK"
     CDS             complement(13704..14009)
                     /locus_tag="ctg19_15"
                     /transl_table=11
                     /translation="MEKTMTLNLRVNPTVKQQAEDVLKQLGIPMATAIDMYLRQITLTG
                     GIPFSLSLPKAPAALNADTMTDDQLHAALQVGIKEIQNGDTVDAASAFAQFREQHR"
     CDS             complement(14247..14456)
                     /locus_tag="ctg19_16"
                     /transl_table=11
                     /translation="MKKILTAIVSVSIFIVGILLILCADTNFLWYAFNQNVRLTVVAGI
                     LIALVGGVGVIMNLWCILKELYSK"
     CDS             complement(14934..15473)
                     /locus_tag="ctg19_17"
                     /transl_table=11
                     /translation="MKEIIIEPHIGIGQLKLGMTSDELENALLQMKKQWSNSSDEAMQM
                     ECCAETDDPNLITGRYMDNDSFFLVQYRNGKAAEIGIQRDLSKVASIKLFGMDMFNTAA
                     ECIIDSLMKKDNVICNEKDLQLGTEYFFPEIGVRLWRERAFHPKLLKDPLYMEEMQAVL
                     EDEYQYQYFQMVTVMG"
     CDS             complement(15470..15739)
                     /locus_tag="ctg19_18"
                     /transl_table=11
                     /translation="MWFFSLAFFAVIFMEMLSDFLLVTERRNTWKALNGNVSEAEFHNL
                     QQIVLCENQKVSIEKKLASTILLVLMICATAAFVWLTFWYKVLL"
ORIGIN
        1 tggttggcgg attttttcat tttagggctt gacttttaat agttagtctt cgtcagagag
       61 cggtaggctt ctgccacctt gcctttgggg tcgtgttgaa aaatgctctt gcccacggca
      121 ctgatctccg cagcacggac agaccgggga atggtctggt cgaacacttt gatcttactg
      181 ccgtaggcac ctcgaatcag gttgtcgatc tgctgcccat agttggtgcg gctatctgtc
      241 atagtcagca ggatgccctc gattttcagt ttcgggttga tctgccgtcg gaccttctgc
      301 acggtctgca aaagctgttc caagcctttc gcagacaggt actgcgcctg caccggaatc
      361 agggtggtgt ccgccgctgc cagtgcattg acggtcagca tcccaaggga aggggtgcag
      421 tccagcagaa tgaaatcgta ttcgtgcttt gctccttcca gcacctgctt gagcatcttt
      481 tcccggttca tgcagttgac gagagacact tccagccctg ccagttcgat gttcgccgga
      541 atcaggtcaa cgccctctac atggtgcaga acgccctcgc cgggctggat gggctgatcg
      601 ttcatgattt ttgccatcaa ggtagaaagg gtggtaggca gttcatcggg ctgctgccag
      661 cccatgctga tggtaagtga tccctgcggg tcagcgtcca ccaacaggac cttcttgccc
      721 tccatcgcca gaccgatgcc tagattttca caggtcgtgg tcttgccggt gccgcctttc
      781 tggttgacga tggctattgt ggttgctttc tttgaaattt ttatcacctc cgcatcgcta
      841 agtcgtggtt ggtttggttc tggtaggaaa gctgcatcgt ggtgggtgcg ttgtacagag
      901 aagcgagcag gtattgtttc atgtttcgga tcgggctgct gttctctgca aggcacttca
      961 gcacaaagcg gatatggtcg gcgttcagct tcataaagcg actgcgtacc acctcggcgg
     1021 gcttatcgtc cccggcaata cgcagcgtct tgcggttggt ggcgcaggtg tccaccagca
     1081 aatctacaat ctgatagatg gtatcctcat cgtccgggca aagacggagt agaagttcta
     1141 cctccaaaga ctgagaaaag tactctttca gttgttcgcg tttgctcatc tcatctgctt
     1201 cttctgaata gaaaggatac gtttcactct tttcagtatt attttcatca gtcttattac
     1261 atcgtgattt tgcagggtct tgacttgcgc ttttgaagcc tccagaatcg tgaaaatcac
     1321 gattctggaa tattgatttt gacgattctg ctgaaaagtt cttcacatac accaaacttg
     1381 gctttcccag acctctgcgt tttcgttcaa tcaaaccaaa cttttcaagt tcccggagca
     1441 acttggttgc tttgttgtct gcgcaacaca acgccctctt gacatcctca attgtgaaga
     1501 tgatgaatac ccggccctgc tcgtccagcc agccattttt agcagaaagg ctcatgcggt
     1561 cgagcaggat accgtacagt gttttggcat cggttgacaa gttctggaat cgtggttcct
     1621 gaaacagtgc tttcgggatg cggtagaatg agaaaagttc tccggcttgt ccgtagaagt
     1681 aatcaagggt catgtggctg tgctctgaaa tagcgtcggt aagatgttga cattgtagaa
     1741 aacctcctcg caatagattt tttgaaataa aaaagcgcaa ttccgatttt tgaaaatcaa
     1801 aattgcgctt ttccgcttga taaataagaa gatttcaacc tgtttggtgc cgaaaggggg
     1861 ataaaacatc ttgacaacac ctagagacag gttgtaaact atacatcgtc aataaaactc
     1921 tttaagcaac agagttgctt ttgggtgaga atgtgccttt ctcgaaataa aacgttctaa
     1981 cgataaatat cgttcattct cgcacctttg cgtgggggtg cgtgagtgcg tggttcggga
     2041 gagcgcttgc atggcatgca agaggtcacc ggttcgatcc cggtaatctc caccagaacc
     2101 aaagcactac acaaaaacgt gtggtgcttt tttgttgctg ccaaacgagt gagggtttag
     2161 ctcacccagg agagtgccgt gcatggactg caagagggtc accgtgatta caacagcccg
     2221 gtaatctcca ccagaatgaa agcactacac ggaaacgtgt ggtgcttttt tgttttatct
     2281 gccgttcacc ttacgtcctc tttcatgaaa aaagcgtttg tcgcagcccg caggccgtga
     2341 caaacgcttt ttattttact gtgcacccag acgcattttg aagtcctgat agccaaagtg
     2401 caccagctcc cggcaattgc cgtctgcgcc cagcagccag ataggcggca ggggcatccc
     2461 gttgaaggtg ttgttcttgc aggtggtgta gatggccata tcgccaaaga taagcttatc
     2521 tccctcggca agaggggcgt caaagctgta atccccgatg atatcccccg caaggcatgt
     2581 ggggccgccc agccggacgg tgtgcgcctt ctctcctgcc tcgccggcgt ccagcagcgg
     2641 cgggcggtag ggcatctcga tgacatccgg ggtgtggcag gctgcggaca tatccagaat
     2701 ggcaagactg gtatccccgt tgcgcagggt gtccagcacg gtggtgacga gatatcccgc
     2761 gttcagcgcc caagcctcgc cgggctccag atacacctgt acgccgtact tctgtcgcac
     2821 cgagaggatg cagctttcca gcgtgccaag ggcataaccc gggcgggtga tgtggtgtcc
     2881 cccgccgaag ttgagccact tcattctggg cagcaggtct gcaaactttt tctccactgc
     2941 ggccagcgtt accgccagcg catcggcgtc ctgctcgcac agggtatgga agtgcagacc
     3001 gtccagcagg gcgggcagct ccgggtgcgc cgccacagca tcgtcccact gagcacgggt
     3061 ggtgcccaga cggctgccgg gtgcgcaggg gtcgtaaatt tcgtgcccct cctgcgtgga
     3121 gcactccggg ttgatgcgca gaccgatgct tttgcccgct gcctttgccg ccgggccgaa
     3181 ctttgccagc tggctgggcg agttgaacac gatgtggtcg gcgtattgca gcaattcctc
     3241 aaactcatct gcccggtagg cggcgcagaa cacatggttc tccttctccg gcagctcttc
     3301 cctgcccaag cgactctcgt acaggccgct ggcctcggta ccagccagat agggtgccag
     3361 caccgggtag acgttaaagt tggaaaaagc cttctgcgcc agcagaatgc ggcagccggt
     3421 gcgctgctgc acacccagca ggatctcacc gttgcggcac agttgggctt cgtccagcag
     3481 atagcagggg gtgggcaggc ggtgcagctg ctcctcggac aggtttgcca gccccgcaaa
     3541 gggcgggcgg ctgtcgcgca cccgcatcag tccaccagag ccgggtcatg gctctcggag
     3601 cggggcaggc cgtacttatc cagtgcatcc agatacggat cgggatcaaa ctcttctacg
     3661 gtgtgcacgc ccttggtggt ccacttgccg gtgagcagca tcagggcacc gcacatggcg
     3721 ggcacgccgg tggtgtagct gatggcctga ctgcccactt ccttgtagca ctcctgatgg
     3781 tcacagacgt tgtagatata gtaggtctta tccttgccgt cctttttgcc ggtaaagatg
     3841 cagccgatgt tggtcttgcc tttggtacgg gggccaaggc tggcggggtc cggcagcaga
     3901 gccttgagga actggatggg cacgatctcc tgtccgttga agttgacagg ggtggtggac
     3961 agcatgccca cgtcctccag acaacgcatg tggtccagat agctctggcc aaaggtcatg
     4021 aagaagcgga tgcgctttgc ctccgggatg ttctttgcca gagactcgat ctcctcgtgg
     4081 tgcagcaggt acatatcctt gtcgcccacc tgatcgaagt tgtactcccg cttgatgctc
     4141 atagccggga tctctaccca gtggccgttc tcccagtagc tgccgggagc ggacacctcg
     4201 cgcaggttga tctccgggtt aaagttagtg gcaaaggcat agccgtggtc gccgccgttg
     4261 cagtccagaa tatcgatggt gtcaatggta tcgaactcgt gctttttggc ataggcacag
     4321 taagcctggg tcacacccgg gtcgaagccg ctgcccagca gggcggtcag gccggcttcc
     4381 tcgaactttt tggcgtaggc ccactgccag ctgtaatcaa agtaggcaga gaagccggcc
     4441 tccttgcagc gcttctcgta gatggcgcgc cactccgggt catcggtgtt ctcgggctcg
     4501 tagttggcgg tgtccatgta gttgacgccg caggcaaggc aggcgtccat gatggtcaga
     4561 tcctgataag gcagggcgat gttcatcacg aggtcgggct ggtaagcctt gatgagggcg
     4621 atgacctcct ccaccttgtc tgcgtccacc tgtgcggtgg tgatcttggt agtagtggtg
     4681 ggagccagct cagcagccag cttatcgcac tttgccttgg tacggctggc gatgcagatc
     4741 tcggtgaaca cctcgggcac ctggcagcac ttatggatgg caacagaggc cacgccgccg
     4801 cagccgatga tcagaacttt gctcatgtcg gttactcctt tatctgtaaa atggtaggtt
     4861 cgtatttata cctgaaagcc cggccagccc ttgtccagcg cgatcagggt ctcgcgcagc
     4921 accttgcagg cggtggcggt ggaaacgccg gtggtgtcca gcgtgggggc aagctcgttc
     4981 aggtctgcac cgatgatgtt ggccttggtc acagtgcgga tggcctccag cagctgcaaa
     5041 aagcttacgc cgccagcctc cggggtaccg gtgcccggga agcaggaggg gtcaaggcag
     5101 tccagatcga tggtcaggta caccggcacc ttgctctcgc acagctgtgc ggtcagctcg
     5161 gcaaggccgg taaaatcgaa cttgtgcatc tcggtgtgct gggcagcaaa ctcaaattct
     5221 gcccggtcgc cgctgcggat gcagaactga tggatgtggc catcccctac cagctcgtgg
     5281 cagcggcgca gcacacaagc gtggctgagc ttcgcgccca gatagtcgtc ccgcaggtcg
     5341 gcgtgggcgt cgaaatggac gatgtgcagg tcggggtatt tcttcaccgc agcacgcacc
     5401 gcacccagcg tgaccaaatg ctcgccaccc agcagcagcg ggaacttgcc gtccttcaaa
     5461 atttcctctg cccgggcctc gatatcggcc agtgccagct cgctggagcc gaagcacagc
     5521 tccagatcgc cgctgtcgaa cacatcaaaa tcggtcaggt cggcgttctg gtaagggctg
     5581 taagtctcca gaccgtagct ctcgtgccgg atggccgccg ggccgaaccg tgcaccgggg
     5641 cggtagctgg tggtggaatc gtaaggcgca ccgtacagca cgatgctggc ggcgcggtag
     5701 ctgctgtcgc agccgataaa ggtctcaacg ttggggtgca tcagtgttcc tccacttccc
     5761 gcagcatctc ctccagaaaa gccggcaggt agaatgctcc gatatgcagt ttggtggtgt
     5821 agtagcgggt gcgcatattc agcgccttcc acgattcagc gtccagatca tcgatgggat
     5881 ggtatttttt gcttgcaaag ccgaacagcc agtaccctgc cgcaaaggtg gggatatgcg
     5941 cctgatacac ccggctgatg gggaaggtgg atgcaatgcg cttgtggctg cgctgcatgg
     6001 cgctggcgtc ctcggcgtag aaggggctgc cctgctggtt gaccatgatg ccgtcctctt
     6061 tcagggcgtt gaagcagctg ccgtagaact cgcgggtgaa cagaccctca gaggggccga
     6121 aggggtcgga ggagtccaca atgataaggt cgtactcctc ctcgcagcgg cggatatact
     6181 tcaaggcatt ctcaaaatag atatgcaccc gacggtcatc catacggcag gcattgctgg
     6241 gtaggtaagc gcggcaggcc tccaccacct gcgggtccat ctccacaagg tcgatgcgct
     6301 ccacacggtc gtagcgggtc agctcccgca ccacgccgcc gtctccggca ccgatgacca
     6361 gaatatcctt ggcttccttg tgcaccgcca tgggcacatg gacgatcatt tcatcgtaga
     6421 tgaactcatc gcgctcggtc agcatcacgt tgccgtccag cgtgagcacc cggccgaact
     6481 ccggggtctc aaagatatca atgcgctgat aatcgctctg cttggagtag agctgcttgt
     6541 tcacacgaat gctgtgcttc acatccgggg tgtgaaactc tgaaaaccaa aattccatct
     6601 ctttccctcc ttatgccaga acattcaggt gcaaaatttc ggggtcctcc gggccggtca
     6661 tgctgcagcc cttggccttg gcgtactcga tgtagttcag gatctccttg gtgatgcgct
     6721 cgccgggtgc aaggatgggg atgcccgggg gatagcacat gacgaactcg ctgcacacca
     6781 tgccctcggt ctcccgcagg ggcaggctct ttttgggggc atagaaggcc tcctgcgggc
     6841 tggcagccac cacggggtcg atgtattcct gactcagcag acccgagcca tcggtgcggt
     6901 agcggcgctt gatctcggcc agcgcactga ccagacgctc cacctcctgc gggcggtcgc
     6961 cgatggacag gtaggcaagg atgttgccga tatcgccgaa ctcgatctga atgtcatact
     7021 cgtcccgcag gatgtcgtag acctcgatgc cggcaagacc aatatccagc gtatggacgc
     7081 tgagcttggt ggtgtcaaag tcaaaaacag aatcgccgtt gcacagctcc ttgccaaagg
     7141 cgtagtaacc gcctacggcg ttgatctcct cgcgggcgta ctcggcaatg tctgccacct
     7201 gatggaacac ctgccgtccc cgcagcgcca gattgcggcg ggagatatcc agactggaca
     7261 tcagcaggta gctgccggag gtagtctggg tcaggttgat gatctggcgc acatagcccg
     7321 ggtgcacgtt gggaccgatg agcagcaggc tggactgggt caggctgccg ccgcttttgt
     7381 gcatggagac cgaggccata tccgcgcccg ccgccatggc agaaaccggc aggccgccgc
     7441 caaagtagaa gtgggtgccg tgggcttcat ccgcaaggca gagcataccg gcgtcgtgcg
     7501 ccatttttac gatggcacgc aggtcggagc agatgccgta gtaggtgggg ttattcacca
     7561 gcacagccac agcgttgggg tgctccttga tggcctttgc cacctgctcc cgcttcatgc
     7621 ccagcgagat gcccaggcgc ttatccacct ccgggttcac atacaccggc accgcgccgc
     7681 acagcaccag cgcgttcagc acgctgcggt gcacgttgcg gggcagaatg atctcatcgc
     7741 cccgcttgca ggcggtaagt accatgctct gcacgctgct ggtggtgccg cccaccatta
     7801 aaaaggcgtg tgccgcgcca aatgcatcag cggcaagctc ctcagcttcc cggatgaccg
     7861 acaccgggtg gcaaaggtta tccagcggct tcatactgtt cacgtccacg cccacgcact
     7921 gctgacccag aaaagcggtc agttccgggt tgccgcggcc tcgcttgtgg ccgggcacgt
     7981 caaaaggcac cacccgcatc tgccggaacc gctccagcgc ctcgtaaatg ggcgcacggc
     8041 gctgatccag ccgggaacgc gctttgttct cgttcatcat ttcctccgtc cctgttcttc
     8101 tttttgcaca acaaaaaagc gcagacactg cacaaatatg cagacctgcg cttggagcag
     8161 ctttttccgc gctgataaag cacccagccg taagtgccgg tgctgcgcgt tattcgcgat
     8221 ccaaaaagac ggggtgatga gagtctatat agcaactaca cttttactac tcttattgac
     8281 cgtttcacaa gtctgcgcat aggctgcgca atttcatggt tgtaaaggaa ccaacttata
     8341 aaatttgagc ttcaaactca atcaataatg gcagcttgcg ccgccggtcg gcagtggacc
     8401 cggctgtccg tatggcctta gccccgtttg ggcggtcccg agtaaattgc tttgaaaaga
     8461 ctctgcaagg cggcgtctct caaaatcaac aaaagaataa catgattcgc cccgtctgtc
     8521 aaccaaaact ttttggcagt cgcccgctgc agatgcgcag ggcggcgctc ggcgcgcaaa
     8581 atggagcgtt ttgtgcaaaa aagcagatgc ccttcccgcc gcagtatgct ataataaagg
     8641 aacaatgaat ggagaaagag ggtgtatgga tggcactgcc aatcgccatc gtagaggatc
     8701 agaccccgga cgcccagcgg ctggaggagt tgctgcaaca gcagctgccc gaagccgagt
     8761 gcacatggtt tgcctgcggg gatgattttc tccgtgccgc agcagagccc ggcttatacg
     8821 ccgtggtgtt tctggatatc tgcatggcgg gcaccaacgg catcgagacc gcccgccgac
     8881 tgcggcaggc cgacccggag gtgctgatcg tattcgtgac ctcctcgccg gaatatgtat
     8941 gggatgcctt tccggtgcac cccttcgatt acctgctcaa accctatcag gaggaaaaat
     9001 tcgtgcacct tgccgccgag ctgcggcggg cgctgcgttg taaggagccg gaactggaga
     9061 ttcgcattgc ccgccaaagc attcagctgt cgctgcgcaa ggtgctgtat gccattgccc
     9121 ggaaccacta cgtccttatc accaccgagg atggtgagta ccgcgccatg tgcagctttg
     9181 cgcagatcga agaaaagctt accgcacggg aaaactttat gagctgcaac cgaggcgtta
     9241 tcatcaacat ggacaaggtg ctgcggttcg gggaggactg catcgagatc ttggacggca
     9301 cccgcctgcc ggtacggcag aaggataaat gcactctgct tgcccacttt acacaatacc
     9361 agttccgcca catgcggcag gagctgcact gaggaaagga gcagccgcca tggatcttgc
     9421 tctgttcggc cgttattttc tggattttgc gctgctgtat cccagcgcgt ttctgtgtct
     9481 ggcatcccta tgggaaaagc tgcgcacccc caggcgcacc gcctgcatcg ctgccggatg
     9541 catcaccctg ctgtgcatcg gctgcgccgc gctctgcgcc gtgttcgggc tgaacagcaa
     9601 ttctctcctg cccgccatcg tgctggtctc cttctggctg ctgcgctggc gggtaacgcc
     9661 ggaagtgacc gtaagccaga ccgcgtttct gttttccatc tctgccgtga tgatggcggt
     9721 gtgttccctg ctgtcgacgc tgctcaacgc ccagaccgag atctccaacc cacagaccgt
     9781 ctgccttgcc tccacggcgc tgctgcggct gggccttgcc gcgatgctca ccgtgctgtt
     9841 ctggttcacc gccgtgcagt ggagccggtg gctgctgcgg gagtacagcg gtgaagcctt
     9901 ctggcaatct gcgtggccgc tgcccgccct ctatgccgtt tttctggtat actgtatgcc
     9961 gctgaacccc gccgtggtgc tggtcgggcg gctgaagatc atctcggtgc tggcggtatc
    10021 catctcgctg ttcggcatct ttctgctgct atacgagatg taccgcgttg cccgggagtt
    10081 tacccgcaat gcccggctgg accgggaaaa ccagctgctg gccatggaat cccgccggta
    10141 catggagtta cagacctatc tggacaacac ccgccgtctg cggcacgact tccggcagca
    10201 tctgcatgtg attgccggac tgaccgagac cgggcagctg gaggagctga aaagctatct
    10261 gcaccagtat gaaagcgagc tcagcgagca ccgccccagc ctgtgcgcca acgccgccgt
    10321 ggatgcactg gccggatatt acgaccatgc agccgggcag cagagcgttc ctgtggagtg
    10381 gaagctggca ctgcctcggc agcttcccat gccggaggcc gacctgtgca ccattctggg
    10441 caatctgctg gaaaacgccc tgcacgccag ccagaagctg ccgccggagc agcgccgggt
    10501 gcaggtgatg gcgcagatgc tcagtcccgc catgctgggg cttgtggtgg agaaccgtta
    10561 cgacggcatg ctgaaaaagc agcagggcat cctgcgctcc accaagcacg agggcaccgg
    10621 catcgggctg gtatctgccg agacggtagt gcacaaatat aacggcaatc tgcatctgga
    10681 gaccgaggag cagatcttcc gggtgaatgt tctgttaaat ctgtaaccac cggcaggcca
    10741 acgtgaaagc gttcacaaaa aaagcagcgc cgtcctttgc agagaggttt ctctacgaag
    10801 ggcggcgctg tattattttt caagcttctc cgtgcttttt tgtgcggctt ccagctcgtc
    10861 cacccgcttt tgcagggcgg tgatcttatc gtccattttc aaaaatgtcc agaccagaac
    10921 ggccagcacc agcgcgggag gaacgaccat ccacagggac tgctgacacc agagcagcag
    10981 cgaatagccg ccgaatacag taaaaataaa tacggcaaac agacttgcag ccagtacagc
    11041 aaaaaatccc atacagaaag tctcctttca gttattcttc cgtttcttcc tcgtccgggt
    11101 ccagctcaat gctgaacacg gcttttttca gcttgccgca gccctgcgcc ttcagaccgg
    11161 atttatacgg ttcccccgcc agatacaagg caaagcgtcc ctcgcacagc attccggcaa
    11221 tgctggtacc ggcagtgcct acggtggtgt cggcggcttc atcggttggc ttggtgggcg
    11281 tcagctccgc aaggcttacc tcaaacagct cactgccgtc caagtcagtc tccagcgtaa
    11341 tgtgattgtc gtgccgctgg aacagtgcct tgtcggaggt ctggggcgtg acggtgctca
    11401 cggtgaccac cgccttgtcc ccatcgatgc gggtgcgccc ggcaggcagg gtggtgatat
    11461 cccgcgccat gatgtactcg atcacggtgt ccagattgtc gcttacgccc agatagttgg
    11521 gcaggttgtt cagggtatcg tagatcatag aaaaagtcct ccgtctgtgt tgtttcagtt
    11581 acctgtatgg tatcacaggt cagggacaga tgcaatatgt gtgcgggcag atgtcgcgag
    11641 ccgcgcagaa aaggaacccg ggtcgcggct cccagcggct gcgtcgtgcc ttgggcggca
    11701 cgcgcatcct gctggccgca gccccaacag ctcctccctg tttctgccgc tggcagcggt
    11761 cgtcgctgtt gcacaggggc tttttacccg ccggactatt cggcgggtcg atgctgttcg
    11821 aatccacccg ctctatgagt ttagccttgt cacaaaacaa aaacctcagc gcacttgcat
    11881 acgctgaggc tttttggtgg agcgaagcaa cccaaatccg aaccattgcc ctctggggca
    11941 tctttggcgg cgatctcatc gaaagtgatg gtttttgtgc cgtctttgta gttgaatgta
    12001 atcaaaacct tttcatcata gagataaaca gcattcacaa atgtattgat aagcgtttcc
    12061 cggtggcttt tcacgttcgg gtcgagcttg cggaaccggg tcagccagaa ccgaacctga
    12121 ttttcgctca actgtggccg agcgattttt tcttcggcaa tccgaacctc aagttctttc
    12181 tgctgggctt ccagcttttc caaacgcgat ttggtggaat tggtcagcac acccgcttgg
    12241 atggcgttca gcatattttc aatgccattc tctacctcac gcatctgctt ttccagcaat
    12301 gggagcgtgg tgttttcctg atcctgcaac tccatcactt ccgcaacgat ggcatcaatc
    12361 acggcatcat cctgaatcag cttcatggtt tcagctacga ccaaatcttc cagccattcc
    12421 ttacggacgg tctttttctt gcaggtcttg aaacgcttcg cggtggcgca cttataataa
    12481 tgatgaacga ccttgtttct acccgtaccg cactcgccga acatcatggc accgcacatt
    12541 ccgcagaaca gcttggtggt gagcaagtaa tcgtcctcgg ccttgtgacg ggcaggagcg
    12601 cggctgttct ttttgatttt cagctgcact tcctcaaaca aatccttgtc cacgatggcc
    12661 gggatgctgt cgggcattac gatgtccttg aagtggtttt ctccgatgta acgtttgttc
    12721 gtcagcaact tctgaacact gttataggtg aacttctggt tgcggttggt ggtcacgcca
    12781 ctgtcgttca gccagttcat cagttccttc atggtcgcac catcgttgta ccgctgaaag
    12841 gcttctacca caaagggagc tttcagcggg tcgatttgaa aaaacttctc ttcgtccacc
    12901 ttgaaaccaa tgggaatcgt gccgccgttg tacttcccct tcagaacatt ctcggtcatg
    12961 ccgcgcacaa ctttttcaga aagttctgcc gagtagtatt cagccatgcc ggtgagcata
    13021 ctcttgacca tgatacccgc agggctgtca gagatgggct ccgtggcaga caccagcttg
    13081 acatgatttc gttccaactg gtactcatag tgcgctgaat catagcggtt ccgggcaaaa
    13141 cggtcgagtt tccagaccag cacgatgtca aacagccgtt tttcgctgtc cttgatcatc
    13201 tgttggaagt ccgggcggtt atcggttttg gcggaaaggg cacggtcaat gtagtgtttg
    13261 accacagtga tgccgttctt ttcggcgtag gccgtacact cgcgaatctg accttcgatg
    13321 gattcttcgc gctggttgtc gctggaatag cgggcgtaga ttacggcggt catgcgaaca
    13381 cccctttcac ttcattctcc gcaggcggcg cacaaggtcg gatgcgctgt acagcacacg
    13441 agccaccgac actacatcct cacccacgat gtagaacaca gagtagttgt ccaccagcat
    13501 ctgccgcagt ccttgggtgc gctccggctc gctttcaacc agcgcacagc gttccggcag
    13561 gatgttcagc gactggatgg cttccgcaat gcggttatac tgccccatag ccgtgtcagg
    13621 ttccagcaga cggtcagcaa tgtagctgta aatctgctcc atatcactga gggctgcatg
    13681 ggaaattttt acgtcatact gcttcatctg tgctgttccc tgaactgtgc gaatgcgctt
    13741 gcagcatcca cggtatcacc gttctggatt tccttaatgc ccacctgcaa ggctgcatgg
    13801 agttggtcat cggtcatggt gtcagcgttc agagccgcag gagccttcgg cagggacagc
    13861 gagaagggga tgccgccagt cagggtgatc tggcgcaggt acatatcaat ggcggttgcc
    13921 atcgggatgc cgagctgctt cagcacatcc tcggcttgct gcttaacggt cgggttgaca
    13981 cggagattga gtgtcatcgt tttttccata gttatcacct cgattttatt gtaacgtatt
    14041 ttgcgttgca agtcaattcg aggtgaacgc gcaaatgaaa ttctccatat cgcacaatgt
    14101 attcatcgtt aaattgttca aagtgcggga tattcaccct ctataataaa ttcttggagt
    14161 gtgcccagct tttgctgagt agtaagcttg aatattatct ctcttggctg cgaccatggc
    14221 agactggaag tttaaccttc aataaactat ttactgtaca attcttttag aatacaccaa
    14281 agattcatta tcacaccaac gccaccaaca agtgcaatga gaatccctgc aactactgta
    14341 aggcgaacat tttgattaaa ggcataccat aaaaaattag tgtccgcaca aagtataagc
    14401 aaaattccaa caataaatat gcttaccgat acgattgctg taagaatttt tttcatgtta
    14461 cactctcctt tgtgtatcac tgttattctc cgagaaagtt cgactcacat ccctatgata
    14521 gtgaacacat cattcgtttc aaaacacttt gctgcccaag gaactgcttc tgcaataatc
    14581 tctttgcaag tacatccatc cgattgactt tttgttaaaa tattatccca ttgtactttt
    14641 gtaacgattg tcattccata aaagtcaaac tctggaatca cttcaagaat cagatctgaa
    14701 acgtggcggc tattccatat ttcatcactg atgctaatag atgtgtcaag ccagcacttg
    14761 tcgtgatact gcccttgttg aaattccaaa tagcagctgc tgtgtgaggc ttttctttga
    14821 tcttcgtcaa taaaatactt caaattagtt cacccatatt agcagatagc tgcgttcgtt
    14881 gctatgtact acaagcggaa aagttatatc aaatcccatt aatcgttagc aattcaaccc
    14941 atcacagtaa ccatctgaaa atactgatac tggtattcat cttctaatac cgcctgcatt
    15001 tcttccatgt atagcgggtc tttcaacagt ttgggatgaa atgctcgctc tctccagagt
    15061 cggactccaa tttcgggaaa aaaatattcc gttcccagtt gcaagtcctt ttcgttgcaa
    15121 ataacgttgt cctttttcat taagctatca ataatacact cggcggctgt attaaacata
    15181 tccatcccga acaattttat tgatgccact ttagacaaat cacgctggat gccgatttca
    15241 gcagcttttc cgttccgata ctgcacaagg aagaacgaat cattatccat atatcgtccg
    15301 gttatcaaat tagggtcatc ggtttccgca caacattcca tttgcattgc ttcatcagaa
    15361 gaattcgacc actgtttctt catttgtaga agagcatttt ctaattcatc tgatgtcatg
    15421 cctaatttta attgtccaat tccaatatgt ggttcaataa ttatctcttt cataacaaaa
    15481 ccttatacca aaaagtgagc catacaaatg cagcagttgc acatatcatc agaaccagta
    15541 gtatcgtact tgcaagtttt ttctcaatgg aaactttctg attttcgcac aagacaattt
    15601 gctgaagatt gtgaaattcg gcttcgctga catttccatt taacgctttc catgtattgc
    15661 ggcgttctgt aaccagcaag aaatcagaca gcatttccat aaaaatgacg gcgaaaaatg
    15721 ccagagaaaa gaaccacata ccgctccatt ggcttgctgt caaagtatct cggagcgttg
    15781 ccggtttcaa ggactgtacc gcaatgacat aaagtacggt actttgttca cagttgttct
    15841 ccttaatctg ctggcaccta tacaccgtta ttcccatcat gtctaaaagc gaattgattt
    15901 tgcaatttcc aatgcctggc tttccgacac agaacttgct tcaagttcaa ttgcaacaaa
    15961 gcattctttc tcgttatcat aagcgagaac gcctaaattg tttactggtt ctgaatttgc
    16021 accatcttga aaaattaccg ttgtaagtgc agtcgttccg cgttccgtgg tttgtatcac
    16081 atcgtattta ttatccgtgt caaacctgta aaccgatcct agccgaagtg cagagtaaac
    16141 aatctgcacg gaatctctat caccttcata tggttcatag gtactgtatc caaccgcgcc
    16201 aaccaacaca tgatttttgt cataaatatc atatactgga taagacggat tcaggcttgc
    16261 aagagcaagt ggtttatttt cagcacgttg cgtttgttct ctcttttgaa ttttccaccc
    16321 ttgcggaagt tcgattgaaa taacactgct cgcttgtcct aattcttcag tttgaaattc
    16381 aatttgccga tttggtttct ccttgttttc agcttgttct cctaaaatat ctgatgcgat
    16441 ttgtccatat tctttatcag tagtgatgga ttccagatac tgataaagcg tatttctttc
    16501 ttcatccgat cctctatagg gaagctctgt ttttatgccg gataaaacaa gctgctgaaa
    16561 gtctttatca ttcatcagtt tgtcatattt caacacat
//
