LOCUS       c00087_gnlPro..        16507 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JIDJNFDO_87.
ACCESSION   c00087_gnlPro..
VERSION     c00087_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 19:03:23
            Original ID  :: gnl|Prokka|JIDJNFDO_87
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 7150
            Orig. end    :: 23657
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16507
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[17150:21707]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14557
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16507
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16507
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(80..601)
                     /locus_tag="ctg87_8"
                     /transl_table=11
                     /translation="MSTINYDLSRIKALAFDVDGVLSSTTVPLHPSGEPMRTVNIKDGY
                     AIQLAVKKGLHIAIITGGRTEAVRIRFEGLGVKDLYMGSAVKIHDYRAFRDKYGLTDDE
                     ILYMGDDVPDIEVMCECGLPCCPKDAVPEVKSVAKYISYADGGRGCGRDVVEQVLKAHG
                     LWMVEDAFGW"
     CDS             complement(582..1376)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg87_9"
                     /sec_met_domain="F420_oxidored (E-value: 4.8e-14, bitscore:
                     43.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPIVFIGAGNLATNLAKALYRKGFRIVQVYSRTMESAR
                     TLAEKVEAEYTTDLQAVSKDAKLYIVSLKDDALVDLLPQITEGKQASLLVHTAGSIPMS
                     VWEGHAERYGVFYPMQTFSKQREVKFQEVPFFVEAKRPEDVELLKAVAATLSEKVYEAS
                     SEQRKSLHLAAVFICNFTNHMYALAADLLEKYNLPFDVMLPLIDETARKVHELAPRDAQ
                     TGPAVRYDENVMSNHLAMLVDSPALQEIYKLMSKSIHEHHQL"
     CDS             complement(1384..1719)
                     /locus_tag="ctg87_10"
                     /transl_table=11
                     /translation="MGAAKANNSKDTYLATAVTFIVIGALFLIDKLIHFSSIGLPWVMN
                     KDNMLLYASICFLIFKRDKSIGFVLLGLWLVMNIGLVMSLLGSLSGYLLPLTLLIIGIV
                     LFWFAKR"
     CDS             complement(1722..2258)
                     /locus_tag="ctg87_11"
                     /transl_table=11
                     /translation="MENFSELIKNRRSMRKFTDEELTQDQVVALMKAALMSPSSKRSNS
                     WQFVVVDDKEVLKELSHCKEQASSFIADAALAIVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWVQVRERFTATGMPSDEFVHGILDIPLQLQILSVIAIGHKGMERKPFNEE
                     HLQWEKIHINKFGGK"
     CDS             complement(2702..3244)
                     /locus_tag="ctg87_12"
                     /transl_table=11
                     /translation="MLEEILAYNKQFVENKGYESYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EEMLEKMKARGINPDYIDMMRFCGVDFHSWLDGFEDTEKSVRGTVDFIVRHPLIPSDVT
                     VYGFIIDSTTGELTRIV"
     CDS             complement(3358..5253)
                     /locus_tag="ctg87_13"
                     /transl_table=11
                     /translation="MQTQCYNPIYSQLYTVTDFLSVAEAGTDTWLTANNNDNSKELFYY
                     ESLTPSKDKAWDKLFMQAYTALGICNTVINRAESVEGNADDIRVLTAEARCLRGFYHLI
                     LTTYFGPITLCMNEAGNNIVLEPKRNTLSEIYSYIIDDLKYAADNLNTTPYGNNRARVS
                     KKSAMGLLARAYIQGAGQGLSENGVSYWQRAADVAESFIADTEAGGGTYGGYLYKDISD
                     MWADGNNRTNKEALFVAAGCDAGDDDAWDYSNAGYNKLFTYTYWNQTNLSDISKITSDK
                     QNYFYGRTNNGNCAPSKYLLDCFEPTWDKRWENSFQTAFGAFSMGKVAWIPYTKNIVTL
                     TSDLCQKYGIDASHVGEKIYPYVDCDGKTMSHGGNQYTASVWPKGVTTGDVSTLMTPKK
                     VYVIDYPLPADDNRFFLYLSKEPLSAEDKKDRVYACVNIDDLFDANGNYVKTQNDMPGS
                     YDRTSKVYATYPCLNKFIWSYEGVYYGSNLQIRNGDIFVMRMAEVYLIAAEAEQHLGNG
                     TKAAGYLNTLRARAARSGALESSYKLTTVTEEDIYDEYARELCGEHSRWALLQRHQAFS
                     TRLAKYNKRAASSFKSYNIWRPISQTFLQQIDNAEEYGDNGYGTTAKSGLDGFLQ"
     CDS             complement(5408..8512)
                     /locus_tag="ctg87_14"
                     /transl_table=11
                     /translation="LSAPLSYSVYAEDGVSNTMVQVVTQTKTVKGTIIDESGEPLIGVS
                     IVVKGTSTGTITDFNGNFSIDLPAGRKELVISYIGYKEQTVTVTGNGPVNVKMISDTQA
                     LDEVVVIGYGAVKKRDLTGAVASVKSEDITMNPGTNPMEALQGKVAGLDITRESGQAGS
                     GVKMQLRGNRSLTASGNPMFIIDGMPGDYATLNPNDIESIEVLKDASSTAVYGSSGANG
                     VVIITTKGGKEGKLTANFNAFFGINSWSTMPEVRQGETYMEGLRTAHKNAGTYVDDANM
                     FTNPAYYEAYQNGKYIDWVDELLHTGTVQNYSLSVSGGTKNTKAYMSMNFSDENGQYND
                     DNYKLYSTNIRIDHTINKWFTTGISIQASYVHQNKPFAKIQDGMTAIPYGEIYDENGNV
                     NPYPIEGDAGYLNLLMNNKSNWRNQSQNTKLYVNPYIKITPIKGLTWESRVNGTLTYSR
                     SNSFQGDGSYNFYKAGGNVETDTNAKITQNRSYNYKWENIVTYNFNIAKIHEFTLTGVS
                     TWNHNQTDNTEMTGTGIANNKYLWEGLEKAAVQKNSSSYTMSKGVGLVGRINYSLLGRY
                     LLSASIRRDGSSRLAKDHKWSNFPAVSLGWRISDEKFMESTRNWLDNLKIRVGYGISGT
                     ASIDPYSSSSSLESGWLTLGGEKTQIYNLTKIIANPELTWERSKNTNIGIDASFLNNRI
                     NVTLDMYKTKTEGVIWKKSLPVVNGSYSSKEQYLTNINLCETKNKGLELALNTRNIETK
                     NFQWTSALTFAYNKEEITKLTGTANDKVINGDYTYAVGSAINSFYHYKLDGIWQKGEEA
                     DAAVFGLKPGSIKINVPDMVRHTDTDGSVYYTKVNADGQEIRYDASNTYSVSADDYQVL
                     GHNSPDWTMGFQNTLTYKDFDLSIYMYMRWGQMLKYSVLTDYDPTGLNNYPTYFNVWSE
                     TNPSNDFPAMDASIKDKLSYYPGFAALSYVDGSFFKIKNITLGYTMPDKLAKKLGLGKL
                     RVYGTITNPFVIAKSHLLKDYDPEMNGGLNYPLTKQLVFGLNLSF"
     CDS             8827..9825
                     /locus_tag="ctg87_15"
                     /transl_table=11
                     /translation="MPLKLTTYYHGKDIPELPGKNTFHSKELFLIYEATPGYTPLLIVA
                     TEDGRPVARLLAAIRKAKKWLPSSLVKHCVVYSEGEFLDESLSTNKEKAEEVFGDMLEH
                     LTQEASRSCVLIEFRNLNNSMFGYRVFRTNDYFPVNWLRVRNSLHSMEKTEDRFSPSRM
                     RQIKKGLKNGARVEEAHTVEEIHDFSRMLHKIYSSRIRRYFPANDFFRHMNNMLIKGQQ
                     AKIFVVKYKEKIIGGSVCIYSGDDAYLWFSGGMRKTYALQYPGVLAVWKALEDAHQRGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRVNWSWLNKLLVKFYV"
     CDS             10001..10405
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_16"
                     /sec_met_domain="Glyoxalase_4 (E-value: 6.1e-24, bitscore:
                     75.1, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAEGKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             10434..11987
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_17"
                     /sec_met_domain="CT_Btheta (E-value: 3.7e-290, bitscore:
                     952.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGFELIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPT
                     KPYDMYEVIGAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             12019..12939
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_18"
                     /sec_met_domain="OAD_gamma (E-value: 1.3e-15, bitscore:
                     48.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILIDNQNNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWIGLFDSGRKLLDQIVVPAGVLGPNQSYARVSDGAAEW
                     EVKGGSGDKYVTPSTNNKTLDSNAKMEKFEEHDADGVGMSISAMSVVFCGLILLFIAFK
                     IVGKVAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPPRK"
     CDS             12964..13395
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.7; E-value:
                     2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_19"
                     /sec_met_domain="Biotin_lipoyl (E-value: 7.5e-22, bitscore:
                     67.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKPA
                     AKPVTVRPMPNAPTAPTQVVKPTAPSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVNKGDSVLEGNDLVIIE"
     CDS             complement(13418..13831)
                     /locus_tag="ctg87_20"
                     /transl_table=11
                     /translation="LHRVEAHFQCDHVSTEDTELCSSTDQHQFRIRDKCREVRHGADAQ
                     KDERRIPAGSYSLIQYIQYGTFFINTDFQSGIHIKRYITDQHTEADRNQQHRFELFGYR
                     QIDEPQTHKNHNDMPYSSICKARVCPEVGEVIS"
     CDS             14072..14557
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_21"
                     /sec_met_domain="OAD_beta (E-value: 1.7e-65, bitscore:
                     211.8, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTI
                     TILLGLTVGASTQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNIFLKKGNKINP
                     LIGNAGVSAVPDSARISQVIGLEYDSTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             14852..16192
                     /locus_tag="ctg87_22"
                     /transl_table=11
                     /translation="MKRIIILFFLCCTIPLIAQHTDPIQEAMANYDYETALSLIAQKKT
                     TPPLLLQKGKALRGLGLTTEALATYQEIICNDTTNTRAFIEAAECCRALAKYNQALKYY
                     EHALDLNPENKYVRIQYISLLLSQQKFSEALGESSLMTEKDSSAIVLHLQAQSFEGMGE
                     LLPAAGCYYNIQAKYPDDYLAASKLGALNISGSYFDEAIEATEKYRQIDSTNISVNRQN
                     ALAYCLKQDYPTAIRRYEYLVSQGDSSFHTCYYLGISYYAAEKYYEAHDFLEVARKYDP
                     NNINLLYYLGRACSKTSWKKEGVDYLEKTIDLSIPKDSSMTRLYIGMTDCYKMAQMYKE
                     QIASIKERYQRYDKQNHKLLYDMAYIYFYDLKDKKNAERYLEAFLKTRPKDTKEEAEMN
                     ERGELVLGKSNYYNAAAKWLKDIQSKQKIEDFFQNSSPQLPLPKKDK"
     CDS             complement(16277..16507)
                     /locus_tag="ctg87_23"
                     /transl_table=11
                     /translation="GIPEEELRKAAKSAVCKINIDSDSRLAMTAAIRKVFAEKPAEFDP
                     RKYLGPARDNMEKLYKHKILNVLGSDNKLAQ"
ORIGIN
        1 agctaatata atctgatatt tatttaagtt atcaagcatg gttttattcg ttattaaaca
       61 acgattattt atgattaagt taccaaccga aggcgtcttc caccatccat agaccgtgag
      121 ctttcagcac ctgctccact acatcacgtc cgcatccacg accaccgtct gcataagaaa
      181 tatactttgc aacggatttc acttccggca cggcatcttt cgggcagcat ggcagtccgc
      241 actcacacat cacttcaata tccggcacgt catcacccat atatagaatt tcatcatcgg
      301 tcaatccgta cttatcacga aaagcacgat aatcatgtat cttcacagca gaacccatgt
      361 ataaatcctt cactcccagt ccctcaaaac ggatacgtac cgcttctgtc cggccaccgg
      421 tgatgatagc tatgtgaagt ccttttttca cagccaactg gatggcgtac ccatctttga
      481 tattcaccgt gcgcatcggt tctccggaag gatgcaaagg tacggttgtc gaactcaata
      541 ctccgtccac atcaaaagct aaagctttga tacgggataa atcataattg atggtgctca
      601 tggatacttt tgctcattag tttatatatt tcctgcaatg ccggagaatc taccaacatg
      661 gcaagatgat tactcatcac attctcatcg taacgaacag cgggtccggt ctgtgcatca
      721 cgtggcgcca attcgtggac tttacgtgct gtttcatcta tcagcggaag catgacatcg
      781 aaaggcaagt tgtatttttc aagcaaatca gctgctaatg catacatgtg attggtgaag
      841 ttacagataa aaacagcagc caaatgaagg ctcttacgtt gctcggaaga agcctcgtag
      901 accttttccg aaagtgtggc ggcaacagcc ttcaacaatt ccacgtcttc cggccttttc
      961 gcttcaacaa agaaaggcac ttcctgaaat ttaacttcac gttgtttgct gaatgtctgc
     1021 atcggataaa atactccgta acgttctgca tgcccttccc aaacgctcat cggaatgctt
     1081 cctgccgtat gcaccaacaa agacgcttgc tttccttctg ttatctgcgg taacaaatct
     1141 actaaagcat catctttcaa cgatacgata tacaattttg catctttgga gactgcctgt
     1201 aaatctgttg tatattcagc ttctactttc tcggctaagg tacgggcaga ttccatagtc
     1261 cggctatata cctgtacaat gcggaaacct ttacgataaa gagctttcgc cagattagta
     1321 gccaagttac ctgcaccgat aaacacgatc ggtgtatctt ctatacttct tttcattatt
     1381 ctcttatcgt tttgcaaacc agaataaaac gattccgatg atgagcagtg tcaatggcaa
     1441 cagatatccg gataacgaac ccaataagga catgaccaaa ccgatattca tcactaacca
     1501 aagcccaagc aacacaaaac caattgattt atcgcgtttg aaaataagga aacagatcga
     1561 ggcgtacaat agcatattgt ccttattcat cacccagggt agcccaatgg aagaaaaatg
     1621 aatcagctta tcgatcagaa aaagtgctcc gataacgata aaggtaacag cagtagccag
     1681 ataggtatct ttactattat tcgctttagc agctcccata cttattttcc tccgaacttg
     1741 ttaatatgaa ttttctccca ttgaagatgt tcttcattga aaggtttacg ttccatccct
     1801 ttatgtccga tagcaatgac agaaagaatc tgaagttgca agggaatatc caaaattcca
     1861 tggacaaatt catcggaagg cattccggtg gcagtgaaac gttcgcgaac ctgcacccaa
     1921 caacttccca agccaagatc ttcagcctgc aactgtatca tgatggaagc aatggaagcg
     1981 tcttcaatcc aaacatcgct ggccaacgga tcggccatta caacaatcgc caaagctgca
     2041 tcggcaatga acgaagaagc ctgttctttg caatgagaca attctttcaa tacctcttta
     2101 tcatcaacca ctacaaactg ccaactatta ctacgtttgg aagaagggga catcaaagct
     2161 gctttcatca atgcaactac ctgatcttgt gtcaattctt catcggtgaa cttccgcata
     2221 ctacgacggt tctttattaa ttcactgaaa ttttccatat tatttccggt ttcatttgat
     2281 taatgtatgc aaagataatg caaaccgagc gtaataggaa ataaaagttt atactaaatg
     2341 aagaatatat tgtatctttg cacagagaaa taatttcatt atgaaaaagc gaattacaca
     2401 agacgattac gttaaagcga atcgtaaagc tagccgtgag gcagaaattg agatgtacgg
     2461 acaccctatt tgtcaccaac gagtgcacca gtcaaagaaa gtatataacc gcagaaagat
     2521 aaaggcagcc gacaaaaagc tgccttattt ttttgtcttc aaaatagcgt cactatcctc
     2581 cagacatagc gacactatac aataagaatg gcgtcactat catgatagga tagcgtcact
     2641 atatttaggg gattaaaaaa gcagtttatc tatttaccta tttacctatc tatctaatta
     2701 tctatacaat ccgcgttaat tccccggtcg tagaatcaat aataaatccg tagactgtca
     2761 catctgaagg gatcaaagga tggcgtacaa taaaatcgac tgttcctctc accgactttt
     2821 ccgtatcttc gaaaccatcc agccacgaat gaaagtcaac tccgcagaaa cgcatcatgt
     2881 caatataatc cggattgatt ccgcgtgctt tcattttttc gagcatttct tcactatgca
     2941 tatggcaagc tccacaatca gaatgagcaa tcaccattat ttcctctact cccaactcaa
     3001 aaatagcaac aagcaaacta cgtatcacgc taccgaaagg atgggaaata acgccacctg
     3061 cattttttat cattttcaca tcgccattct taattcctaa tgctgctggc agcaaagcag
     3121 tcagtcgggt atccatacag gaaagaatag ctattttctt atcgggatat ttattggtaa
     3181 tatacgattc gtatcccttg ttctcaacaa attgcttgtt gtaagctaaa atttcttcta
     3241 acatagttcc gctttttaaa agttctgttc gattacacaa agatatagaa aatatagaaa
     3301 aaagggacat atcatcacga catatcccct ccgaaaatta gaatttaatc tatattgtta
     3361 ttgtaaaaat ccgtccagac cagacttagc tgttgtacca tatccattgt ctccatattc
     3421 ttcagcatta tcaatctgtt gaaggaatgt ttgtgatata ggacgccata tattataaga
     3481 tttaaaactg gaagcagcac gtttgttgta tttcgccaaa cgagttgaga atgcttgatg
     3541 acgctgcaac aatgcccaac gtgaatgttc tccacaaagt tcacgtgcat attcatcgta
     3601 gatatcttct tcggtgacag tagtcagctt ataagacgac tccaaagctc cggaacgagc
     3661 cgcacgggca cgaagcgtgt tcaaatatcc tgcagctttt gttccattac ccaaatgttg
     3721 ttcagcctcg gcagcaatca aataaacttc tgccatacgc atcacaaaaa tatcaccatt
     3781 acggatttgc aagttacttc cataatatac tccttcataa ctccagataa acttattcag
     3841 acatgggtat gttgcatata cttttgaagt acgatcataa ctgccaggca tatcattctg
     3901 tgttttcacg taattgccat ttgcatcaaa caaatcatct atattcacac atgcataaac
     3961 acggtctttc ttgtcttccg ccgacaaagg ttctttggac aaataaagaa agaaacgatt
     4021 atcatccgca ggcaatggat aatctattac atatactttt ttaggagtca tcaatgttga
     4081 tacatcccct gtagtcaccc ctttgggcca cacagatgct gtatactgat ttcctccatg
     4141 agacatcgtt ttgccatcac aatcaacata gggataaatt ttttcaccca catgagaagc
     4201 atcaatacca tacttctgac ataaatcgct agtcaaagtc actatattct tagtatacgg
     4261 aatccatgcc acttttccca tagaaaatgc cccgaaagca gtctggaatg aattctccca
     4321 acgtttatcc caagttggtt caaagcagtc cagcaaatat ttagatggtg cgcagttgcc
     4381 attgttggta cgtccataaa aatagttctg tttgtcagat gtaatcttac taatatccga
     4441 caggttcgtc tgattccagt aagtatacgt aaacaattta ttatatcccg cattcgaata
     4501 atcccatgcg tcatcatcac cggcatcaca acctgctgca acaaaaagcg cttctttatt
     4561 agtacggtta ttgccatcag cccacatatc cgatatatct ttataaagat aacctccata
     4621 agtacctccg ccagcttctg tatccgcaat aaagctttct gcaacatctg ccgctctttg
     4681 ccagtaagaa acaccattct cactcaaccc ctggccggct ccttgtatgt aggcacgagc
     4741 caaaagtccc atagccgatt tttttgaaac acgggcacga ttattaccgt aaggagttgt
     4801 attcagatta tctgcagcat atttcaaatc atcaatgatg tatgaataaa tttcagataa
     4861 cgtattacgt ttaggttcca acacaatatt atttcccgct tcattcatac aaagagtgat
     4921 cggaccaaaa tatgtagtca atatcaaatg ataaaaacca cgcaaacaac gtgcttcggc
     4981 tgttaacaca cgaatatcat ccgcatttcc ttctacactt tccgcacggt ttataacggt
     5041 attacatatc cccaaagcag tatacgcctg cataaataat ttatcccatg ccttatcttt
     5101 actcggcgtc agagattcat aataaaagag ttcttttgag ttatcattat tatttgccgt
     5161 caaccacgta tccgtaccag cctctgcaac agataaaaag tctgtcacag tatacaactg
     5221 actataaata ggattataac actgggtttg cattccgtac cacccgtcaa acgtagccaa
     5281 cgtttcttcg ccggtaactt ccattggatt atattcatcc aatgaacatg aattgatagt
     5341 aaccatcgca cacaatgcta aggccacatt atatactaat ttcttcatta tttatcagtt
     5401 tagagaatta aaatgaaaga ttaagaccaa agactaactg ttttgtcaat ggatagttca
     5461 aaccaccatt catttccgga tcataatcct tcaacaaatg actttttgca ataacgaatg
     5521 gattagtaat cgttccatac acacggagct tgcccaatcc caatttttta gccaatttat
     5581 caggcatagt atatcccaat gttatattct ttattttaaa gaatgatcca tctacatacg
     5641 acaacgctgc aaagcctgga taatagctca acttatcctt gatagaagca tccatggctg
     5701 gaaaatcgtt cgaaggattt gtttcagacc atacattgaa ataagtagga tagttgttca
     5761 accctgtcgg gtcataatcc gtcaatacag aatatttaag catctgtccc caacgcatat
     5821 acatataaat acttaaatca aaatctttat atgtcaaagt attctggaaa cccattgtcc
     5881 aatccggaga gttatgtccc aatacttgat aatcatcagc agacacagaa tatgtattag
     5941 aagcatcata acggatttcc tgtccgtcag cattcacctt cgtatagtag acactaccgt
     6001 ccgtatccgt atgccgcacc atatcaggca cattaatctt tatagatccc ggcttcagtc
     6061 caaacacagc agcatcagct tcttcacctt tctgccagat accatccaat ttgtagtgat
     6121 aaaaagagtt gattgcacta cctaccgcat acgtataatc gccattgatt actttatcat
     6181 tagcagttcc ggtcagtttc gtaatctctt ccttattata tgcaaaagtc agagccgatg
     6241 tccattgaaa atttttagtt tcaatgttgc gggtattcaa agcaagctca agacctttat
     6301 ttttagtttc acacaagttt atattggtca gatattgctc tttagaacta taggaaccgt
     6361 tcactacagg taatgatttt ttccatatca caccttccgt cttagtctta tacatatcca
     6421 atgttacatt gatacgatta ttcaggaaag aagcatcaat accgatattg gtgttctttg
     6481 aacgttccca tgtcagttcc ggattagcta ttattttagt gagattataa atctgcgttt
     6541 tttcaccacc taatgtcaac catccggact ccagagaaga agaggaagaa taaggatcaa
     6601 tactggccgt accagaaata ccgtaaccca cacgaatttt taaattatcc aaccagtttc
     6661 ttgtactttc cataaacttc tcgtcagaaa tacgccatcc caatgaaaca gccgggaaat
     6721 tagaccattt atgatcttta gccaaacgtg aagaaccatc ccgacgaata gaagcagaaa
     6781 gcaaatacct acccaataaa gagtagttga tacgtcctac taatccgact cctttagaca
     6841 tggtataact ggatgaattt ttctgaacgg cagctttttc caatccttcc cacaaatatt
     6901 tattgttagc aatacctgtt cctgtcattt ccgtgttatc cgtctggtta tggttccagg
     6961 tagacacacc agtaagcgta aattcatgta tcttagcaat attaaagttg taagttacga
     7021 tattttccca cttataatta tatgatctgt tttgagtaat cttggcattt gtatctgtct
     7081 ctacatttcc tcccgcttta taaaagttgt acgagccatc tccctggaaa ctattcgaac
     7141 gggaataagt caacgtccca ttcacgcgtg actcccatgt caatccttta atcggagtta
     7201 ttttaatata aggattcaca tacagttttg tattctggga ttggtttctc caattacttt
     7261 tattattcat caaaagattc aaatagccgg catccccttc aatcggataa ggattaacat
     7321 tgccattctc gtcatagatt tcaccataag gaatagccgt cataccatct tgaatctttg
     7381 caaaaggctt attctgatgc acataagatg cctgaatact aattcctgta gtaaaccatt
     7441 tattgattgt gtgatcgatg cgaatatttg ttgaatacaa tttataatta tcatcgttgt
     7501 attgtccgtt ttcatcggag aaattcatag acatataggc ctttgtattt tttgtacctc
     7561 ctgaaaccga caaactataa ttctgaacag tccccgtatg cagcaattca tctacccagt
     7621 caatgtattt cccgttttga taagcttcat aataagcagg gttagtaaac atattggcat
     7681 catccacata agtacccgca tttttgtgag ctgtacgcaa gccctccatg taggtttctc
     7741 cttggcggac ttccggcatt gtagaccagc tgtttatacc aaaaaaagca ttaaaattag
     7801 cagtcaattt tccttctttt ccgcctttgg tagtaatgat tacaacacca ttggcaccgg
     7861 aagaaccata aacagccgta gaagaagcat ctttcaacac ttcaatagat tcaatatcat
     7921 tcggattcag tgtcgcatag tcacccggca tcccgtcaat aataaacata ggattaccac
     7981 ttgctgtcaa tgaacggtta ccgcgcaatt gcattttcac tcctgaaccc gcttgacccg
     8041 attctctcgt aatatccaat cccgctactt taccctgcaa cgcttccatc gggtttgtgc
     8101 ccggattcat cgtaatgtct tccgatttca ctgaagcaac cgcccctgtt aaatcacgtt
     8161 tcttcactgc accgtagcca atgaccacca cttcatccaa tgcctgcgta tccgaaatca
     8221 ttttcacatt gaccggtccg ttacccgtca cagtcaccgt ttgttctttg taaccgatat
     8281 aagaaatgac cagttctttt cttcccgccg gaagatcgat agagaagtta ccgttaaaat
     8341 cggtaatcgt acctgtactt gttcctttca caacgataga aaccccaatc aacggctccc
     8401 cgctttcatc aatgatagtt cctttcacag ttttcgtttg tgtgacaact tgcaccatag
     8461 tattagaaac tccatcttct gcatacacag aatatgacag aggggcagac aataaagaca
     8521 gccctaaaat catggaagcg cgtctatgat gattcttcca tgcttcaaca aatgcattac
     8581 atctcattcg ttctaattta aagttaatat taattctcgt tgttttgcaa aaactattcg
     8641 attataatct taattaaaga cgaaactaat tttaatacgt actcactttt cataccatat
     8701 ttctcctata aaatacattt tctccattaa atacgcaacg atatattata ctttacttca
     8761 agcagctcca acaaattctt tattttgttg ttgaataaag aataaaaagt gtaaatttgt
     8821 acctagatgc cactgaaact aacaacatat tatcatggga aggatattcc tgaattgccg
     8881 ggaaaaaata ccttccattc caaagagtta tttctgattt atgaagcaac tcctgggtat
     8941 actcctttat taatagtggc aacagaagac ggcagaccgg tggcacgcct gcttgctgcc
     9001 atccgcaaag caaagaagtg gctcccttct tctttagtga aacattgtgt agtatatagt
     9061 gaaggcgaat ttctggacga gtctctttcg accaacaaag aaaaggcaga agaagtcttc
     9121 ggcgatatgc tcgaacatct cacacaagaa gcatcgcgca gctgtgtcct gatcgaattc
     9181 cggaacctga acaattcgat gttcggttat cgggttttcc gtaccaacga ttatttccca
     9241 gtcaactggt tgcgggtacg caattcgctg cacagtatgg aaaagacaga agaccggttc
     9301 agtccgtcgc gtatgcgtca gataaaaaaa ggactcaaga atggagccag agtagaggaa
     9361 gcacataccg tggaagagat acacgatttc tcacggatgc tgcacaagat ttattcctcc
     9421 cgcatacgca gatatttccc ggccaacgat tttttccgcc acatgaacaa tatgttaatc
     9481 aaaggacaac aggcaaaaat attcgttgtg aaatacaaag agaaaatcat tggcggttct
     9541 gtctgtatct attcgggaga cgacgcatac ctttggtttt cgggaggaat gagaaagaca
     9601 tacgcacttc aatatccggg tgtgctagcc gtttggaaag cattggaaga cgcacaccaa
     9661 cggggattcc gccacatgga atttatggat gtaggacttc cgttccgtaa acacggttat
     9721 cgtgatttcg ttcttcgctt cggaggaaaa caaagcagta cccgccgttg gttccgcgtc
     9781 aattggagtt ggctgaataa actcttagtc aagttttatg tctaaatgta atctcaagat
     9841 tacaaaacaa tgttttatgc tcctttccca ccattttttc tgtttaataa tccaataatt
     9901 aaatgcagaa atatttcttt attagataag aaatgtcttt ctttgtgctg ttttatgcct
     9961 tataagcaca gatttaaaac caaataaaaa aagtatagtt atgaagattt cacacattga
    10021 acatctgggc attgctgtaa aaagcatcga agaagccctt ccttactacg aaaatgtatt
    10081 aggtctgaag tgttacaaca ttgaaacagt ggaagatcag aaagtaagaa ctgctttttt
    10141 aaaagtgggc gaaacaaaaa ttgaactgtt ggagcctact tgcccggaga gtactattgc
    10201 caaattcatt gaaaacaaag gtgcaggcgt tcaccacgtc gcatttgctg tagaagatgg
    10261 cgtagccaat gcgctggcag aggcagaagg caaagaaatc cgccttatcg acaaagctcc
    10321 ccgcaaaggt gctgaaggtt tgaatatcgc tttccttcac ccgaaatcaa ctttgggtgt
    10381 gttaacagaa ctctgcgaac attaatcata aactctaaaa ccaacaagaa ctcatgagta
    10441 atcaacttga aaaaattaaa gagcttattg aacgccgtgc cgtagcacgt atcggaggcg
    10501 gtgaaaaagc aattgcgaag caacacgaaa aagggaaata cacagcacgc gagcgtctgg
    10561 ctatgctgct tgacgagggt agcttcgaag aaatggacat gttcgttgag cacagatgca
    10621 cgaacttcgg catggagaaa aaacattacc cgggagacgg tgtagtaacc ggctgcggta
    10681 cgatcgaagg acgtctggta tatgtgttcg cacaagactt cactgtttct gccggttcac
    10741 tgtcagaaac gatgtcattg aaaatttgta aaatcatgga tcaagccatg aagatgggcg
    10801 ctccctgtat cggtatcaac gactcgggtg gtgcacgtat tcaggaaggt atcaacgctt
    10861 tggcaggtta tgcagaaatc ttccaacgca atatccttgc ttccggtgtt atcccacaga
    10921 tttcaggtat cttcggtcct tgtgccggcg gtgctgttta ttctccggct ttgaccgact
    10981 tcacgctaat gatggaaggt acttcttata tgttccttac cggaccaaaa gttgtgaaga
    11041 ccgtaacagg tgaagacgtt agccaggaaa acctcggtgg cgcaagcgtt cactccacta
    11101 aatcaggtgt gactcatttc accgctaaaa cagaagaaga aggtttcgaa ctgattcgta
    11161 aactgttgag ttatattcct caaaacaacc ttgaagaagc tccttatgta gattgtacag
    11221 acccaatcga ccgtttggaa gattctttga atgatattat ccccgacagc cctactaaac
    11281 cgtatgacat gtacgaagtg atcggcgcta ttgtggacaa cggtgaattc cttgaaatcc
    11341 agaaagatta tgcaaagaat atcatcatcg gtttcgcccg tttcaacgga caatcggtag
    11401 gtatcgttgc taatcagcct aagtatctgg ctggtgtgct cgacagcaac gcatctcgta
    11461 agggtgcacg tttcgttcgt ttctgcgatg cattcaatat tcctatcgta tcgttagtag
    11521 acgtaccggg attccttccg ggaacaggtc aggaatacaa cggcgttatc cttcatggtg
    11581 ctaagctatt gtatgcttac ggtgaagcta ctgtgcctaa ggttactatc acattgcgta
    11641 aatcctacgg tggttctcac atcgtaatga gctgtaagca acttcgcggt gacatgaact
    11701 acgcatggcc gactgctgaa atcgcagtaa tgggtggagc aggagcagta gaagtattgt
    11761 acgcacgcga agccaaagat caggaaaatc ccgctcaatt ccttgctgaa aaagaagcag
    11821 aatacacgaa actgtttgcc aatccttaca atgcagccaa atacggctac atcgacgatg
    11881 tgattgaacc acgcaacaca cgtttccgcg taatccgtgc tttgcagcag ttgcagacta
    11941 agaaattgag taatccggct aagaagcatg gtaatattcc gttgtaatcc tacttttcac
    12001 attaaaacaa gaacgattat gaacaaaacc aaaatcggaa tattcctttc tttgctgttg
    12061 ctgattgggc tgacttcttg tggagagcaa aagtcgaaca acaagctggt actgaacgaa
    12121 atcctgatag acaatcagaa taattttcaa gatgactacg gattgcacag cgcatggatt
    12181 gaaatattca ataaatcatt cggtagcgcc gacctggcag cttgcttgtt gaaagtaagc
    12241 agccaaccgg gcgatacagt tacttacttt atcccgaaag gtgatatact tacattagtg
    12301 aagccacgtc aacatgcact attctgggca gatggcgaac ctaaccgcgg tactttccac
    12361 accagcttca agctgaatcc ggaaacggcc aactggatcg gtctgtttga ctccggtaga
    12421 aagctgctcg accagattgt agtgcccgca ggtgttcttg gccccaacca gtcatacgct
    12481 cgtgtcagcg acggagcagc ggagtgggag gtaaaaggtg gaagtggtga caaatacgtg
    12541 accccgagta cgaacaacaa aactcttgac agcaatgcca agatggaaaa attcgaagag
    12601 catgatgctg acggtgtcgg catgtccatc tctgccatga gtgtagtatt ctgcggattg
    12661 attcttctct ttattgcctt caagattgta ggaaaagtag ctgtaaattt gagcaagcgc
    12721 aatgctatga aatctaaagg cattgacaag catgaagcta aggaactgtc acaggctccg
    12781 ggcgaagttt acgctgcgat ttctatggca ttgcacgaaa tgcaggatga agtgcacgac
    12841 gtagaagaaa cggtactgac catcactcgc gtaaaacgca gttactcacc atggagttcg
    12901 aagatttaca ctttgcgtga aactcctccc agaaagtaag tcacctttta aaaagttaaa
    12961 acgatgaaag aatataaata taaaatcaac ggtaactcat ataaagtaac catcggagat
    13021 attgaagata atatcgctca tgtagaagtg aacggtacac actataaagt ggaaatggag
    13081 aaacagccga agcctgctgc caaacctgta acagtacgtc ctatgcctaa tgctcctact
    13141 gctcctactc aggtagtgaa accgactgct ccgtctaccg gaaaatcagg agtgaaatct
    13201 ccgctgccgg gtgttatcct cgacatcaaa gtgaatgtag gcgatactgt aaagaaagga
    13261 cagaccatta tcatattgga agccatgaag atggaaaaca atatcaatgc ggataaggac
    13321 ggtaagatta ctgccatcaa cgtcaacaag ggagactctg ttcttgaagg taatgacctc
    13381 gtaattattg aataatatgg gagattttat aaacttttta ggaaataacc tcgccgactt
    13441 ctggacatac acgggctttg caaatgctac tgtagggcat gtcgttatga ttcttgtggg
    13501 tttggggttc atctatttgg cggtagccaa agagttcgaa ccgatgctgc tgattcctat
    13561 cggcttcggt atgctgatcg gtaatatacc ttttaatatg gatgccggac tgaaagtcgg
    13621 tatttatgaa gaaggttccg tattgaatat attgtatcag ggagtaactt ccggctggta
    13681 tccgccgctc atctttttgg gcatcggcgc catgacggac ttctcggcac ttatctctaa
    13741 tccgaaattg atgttgatcg gtgctgctgc acaattcggt atcttcggtg cttacatgat
    13801 cgcattggaa atgggcttcg acccgatgca agccggcgct atcggtatca ttggtggagc
    13861 agacggcccg acggccattt tcctttcttc caagctagca cctaacctga tgggagccat
    13921 tgcggtgtcc gcctactcct atatggcgtt ggttccggtg atacagccgc ctatcatgcg
    13981 tctgctcacc accaagaacg aacgtgtcat ccgcatgaaa ccgccgcgtg ccgtttctca
    14041 cacggagaag gttattttcc cgattatcgg cttgttgctg acctgcttcc tggttccttc
    14101 cggtctacct ttgttgggta tgctgttctt cggtaacctg ttgaaagaaa gtggtgtaac
    14161 ccgtcgtctt gccaatacag ctagcggtcc gttgattgat actatcacta tcctgttggg
    14221 tctgacagta ggtgcttcta cgcaagcttc cgaattcctg acgctcgatt ctatcaagat
    14281 tttcgccctc ggtgcattgt cattcatcat tgcaactgca tccggtgtaa tcttcgttaa
    14341 gatattcaat atcttcttga agaagggcaa caagatcaat ccattgatcg gtaatgcagg
    14401 ggtttctgct gtccccgact ctgcacgtat ctcacaagtg attggtttgg aatacgattc
    14461 gaccaactat ttgttgatgc acgctatggg tccgaacgtt gccggagtga tcggttcagc
    14521 tgttgctgcc ggtatcctgc tcggattctt gatgtaagat ataaggaggc tgtttgaaca
    14581 gttcttaaaa taaaaaataa gactatccta aaagccttga atttataaaa atcacctttg
    14641 ctacattata gtagtaaagg tgatttttca ttataaggac ttgctgtaaa aaagactgta
    14701 gctaccatgc cccatgtatt gtattgcgca ctgttgtgtt accttctctt atcattccgt
    14761 taatctatcc aaaataatct acgaataatt cgtaaatata atatttttag taacttgcag
    14821 cagataagtc aaacaactaa aataaaatat tatgaaacgg attatcattc tgttctttct
    14881 ttgttgtacc attcctctaa tagcgcaaca cacagaccct attcaagaag ctatggcaaa
    14941 ctacgattat gagacggccc tttctcttat agctcaaaaa aagactaccc ctcccctgct
    15001 attacagaaa ggcaaagcgt tgcgtggact aggactcact acagaggcac ttgctaccta
    15061 tcaagaaatt atctgtaatg atactacaaa tactcgtgct ttcattgaag cggccgaatg
    15121 ttgccgagca ctagctaaat acaatcaagc actaaaatat tatgaacatg cacttgatct
    15181 gaatccggaa aacaaatatg tacgtattca atatatcagc ttgcttctct cccaacagaa
    15241 gtttagcgag gcgcttggtg aaagtagtct gatgacagaa aaagacagtt ccgccattgt
    15301 cctgcatcta caagctcaaa gctttgaagg aatgggcgaa cttcttcccg ctgcaggttg
    15361 ctattacaat atccaggcta aatatcccga cgattatctg gcagccagca aactaggtgc
    15421 tctaaatata tccggttctt atttcgacga agccatcgaa gctacagaaa aataccggca
    15481 aattgacagt accaacattt ccgtcaaccg gcagaacgct ttagcgtact gcttgaaaca
    15541 agactacccc actgctatcc ggcgttatga atatcttgtc agccaaggag acagttcttt
    15601 tcatacttgt tattatttag gcatcagtta ctatgcagca gagaagtact atgaagctca
    15661 tgattttttg gaagtcgccc gtaaatatga tcccaacaat atcaatctcc tttattacct
    15721 cggtcgcgcc tgttccaaaa cttcctggaa aaaagagggc gtagactatc tggaaaaaac
    15781 cattgatcta tccattccca aagatagcag tatgactcga ctttacatcg ggatgaccga
    15841 ctgttacaag atggcacaaa tgtacaaaga acagattgca tccatcaaag aacgctacca
    15901 gcggtatgac aaacaaaacc acaaactatt gtatgacatg gcctatatat acttctatga
    15961 cttgaaagat aagaaaaatg cggaacgcta tttggaagca ttcctaaaaa cacgtcctaa
    16021 agacactaaa gaagaagcgg agatgaacga gagaggcgaa cttgttttag gaaaatccaa
    16081 ttattacaat gccgccgcca agtggctgaa agatattcaa agtaaacaaa agatagaaga
    16141 cttctttcaa aattcctctc cacaacttcc tctcccaaag aaagataaat agataagaac
    16201 tataaagcaa ctaaaaggct gctaccggtt tatcggtagc agcctttctt ttatttatgg
    16261 aataatccgg agattattac tgtgccaatt tgttgtcaga accgagcaca ttcagaattt
    16321 tgtgcttgta cagtttttcc atattgtcac gagccgggcc aagatactta cgtgggtcga
    16381 attcagccgg tttttcagcg aataccttac gtatagcagc agtcatagcc agacgagagt
    16441 cagagtcgat gttgattttg caaacagcag acttagcagc tttacgcaat tcttcttccg
    16501 gaatacc
//
