LOCUS       c00011_gnlPro..        12326 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HEKCBFPP_11.
ACCESSION   c00011_gnlPro..
VERSION     c00011_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 18:46:57
            Original ID  :: gnl|Prokka|HEKCBFPP_11
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12326
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12326
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[68:4110]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      69..4110
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..12326
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12326
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(69..635)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_1"
                     /sec_met_domain="HMGL-like (E-value: 2.6e-25, bitscore:
                     79.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEIKKKPVKIVETVLRDAHQSLIATRMTTEEMLPIVDKMDQVGY
                     HAVECWGGATFDACLRFLKEDPWERLRKLRDGFKNTKLQMLFRGQNILGYKPYPDDVVE
                     YFVQKSIANGIDVIRIFDCLNDLRNLQTAVDATKKEGGHAQIALSYTIGDAYTLDYWKK
                     TAKNIEEMGADSICIKDMAGLVVPN"
     CDS             complement(708..1832)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_2"
                     /sec_met_domain="OAD_beta (E-value: 1.3e-157, bitscore:
                     513.8, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVVETMTNLAAQTGFAFLKPGNFIMILVALVFLYLAIAKGYEP
                     LLLVPISFGMLLVNLYPSIMEEGGLLHYFYLLDEWSILPSLIFLGVGALTDFGPLIANP
                     ASFLLGAAAQFGIYSAYFLAMLMGFNGKAAAAISIIGGADGPTSIFLAGKLGQTDLMGP
                     IAVAAYSYMSLVPIIQPPIMKLLTTEKERQIKMEQLRTVTKTEKIMFPIVVTVVVCLIL
                     PTTAPLVGMLMLGNLFRESGVVKQLSETASNALMYIVVIILGTSVGATTSAEAFLNVNT
                     IKIVVLGLVAFAVGTAAGVLFGKLMCKVTGGKVNPLIGSAGVSAVPMAARVSQKVGADA
                     DPSNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             complement(1866..2234)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.6; E-value:
                     4.3e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 8.3e-22, bitscore:
                     66.6, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNYRITVNGVAYDVAVEELGAGEASAAPVSTPAAVPAPAKKAAP
                     KTSGSAGAVKITAPMPGKIVAVKAQAGASVKKGDAVLVLEAMKMENEICAAQDGVIASV
                     EVAVGDMVEGGDVLATMN"
     CDS             complement(2329..2673)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_4"
                     /sec_met_domain="OAD_gamma (E-value: 5.4e-28, bitscore:
                     87.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVFEQALLNTLMGMGTVFAVLIFISLLISLFVYIPSIERALKNR
                     SSKKEKKAAQEERPAPKRPILEEVVEEEELVDDGELVAVITAAIMAANGGAAVSADKLV
                     VRSIKRVKRR"
     CDS             complement(2686..4110)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_5"
                     /sec_met_domain="CT_Vparvula (E-value: 6.4e-137, bitscore:
                     446.7, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNSKMNARERIDYLFDDHSFVEVGGYVSARNTDYNLGAKKVEGD
                     GVITGYGVINDRMVYIYSQDASALGGSVGEMHAKKIASLYDLAMKTGAPVIGMLDCAGL
                     RLQEATDALHAFGTIFNKQAQASGMIPQISAVFGMCGGGSAVMSAMSDFTLMEKENGSL
                     FINSPNALAGNEESRQNTAGAQFQSEQAGNVDFVCETEEGLLDQLRILVDVLPSDYEAE
                     DVYFDNDDDLNRVIPELNDAAYDAAYILKSISDNNMYIETKAAYAKEMVTAFIRLNGET
                     VGAVANHPVDGESVLTRNGLEKAERFIKFCDAFSIPLLTVTNVTGLRANAHEERKQALA
                     LAKFTTTLAQVSVPRINLIAGEAYGTAAEVMNSKAIGADFVLAWPQASVGMMDAEQAVR
                     IMYAEEINTDKNKTALIAEKTAEYAEGQSSALAAAKRGYIDDIIEPDATRKRLIAAYEM
                     LYGKKVTPVTKKHTAV"
     CDS             4833..5474
                     /locus_tag="ctg11_6"
                     /transl_table=11
                     /translation="MENRKIQFRSKACNLHLSAYPGHFATKHSHVNYFLDMTTLKVRQS
                     NAEEAARALVPLYKHNTVVDTIVCLDGTEVIGAFLAEKLTESGFFSYNQHKSIYIVTPE
                     IDSDGQMFFRKNIQPMIKDRNIIILMASVTTGITINRSWECIEYYGGKLQGISAIFSTL
                     SEYGNLPVNALFTPNDIPTYHTYDKHDCPYCKSGQKIDALVNGHGYSELL"
     CDS             complement(5608..6621)
                     /locus_tag="ctg11_7"
                     /transl_table=11
                     /translation="MQKIPECRSMNFSIYEGMLNRYKDSEDIRKSYESRGLNGLEVIRA
                     GEPDEGKILPDMVNGVHLYFHIFWMDWWKGNYERLDQEFDSREQWLEYFGGMSRESYLN
                     SLRDDLAYAEQVGAKYVVFHVSEVTLRESYIYKYRYTDKEVIDASLEVINTLLDEKEYP
                     FDFLVENLWWSGLTLKNVRLTRRLIEGMHTQKKGIMLDTGHYMNTTTQLKTPEDAVAYL
                     NKMIDKYEKAQMLHWFKGMHLQLSLGGDYVRKQRKEWREHPIDFDKIPFYELFRLAYDH
                     ACHIDLHQPFIGEGVREFVERVAPKYVTLEYQQNSREEYEQFVEAQSKILKWITIH"
     CDS             complement(6758..7732)
                     /locus_tag="ctg11_8"
                     /transl_table=11
                     /translation="MADWKSSQEFLKEFYASPIVNEDTISAKIKRIFLPKSRKASALKE
                     LAGDLSGEGRAGDVILDNDMFEMDTEIWKKQEKRRLSVRTRVSLFLLLVAIPLTIAVGF
                     YVMDVAAVGTVFEKIFGPRKYYFISLVIIIYSLLPFFMVFEGRKPQVRELVVLATMVAL
                     ATAGRAAFFMIPSFKPIIAIVIISAIAFGGEAGFLVGAMTMVVSNFLFGQGPWTPWQMF
                     AMGFIGFLSGILYRIGLLPTKRLSLCIYGFLVTVFIYGGIMNPAALFMSVYDFTWEGLL
                     AIYISGIPVDLVHASSTFIFLWIGAKPLLEKLQRIKIKYDLMR"
     CDS             complement(7736..9529)
                     /locus_tag="ctg11_9"
                     /transl_table=11
                     /translation="VTANGLSEKKNSILEINDLCFAYPEEKKRALNHVSLQVEDGEFLV
                     LCGKSGCGKSTLLTHLKTPLTPHGKRKGEILFQGVSIGEMSNREQSQRIGYVLQNPDNQ
                     IVTDKVWHELAFGLESLGYSNADIRIRVAEMASYFGIQDWFYKNVSELSGGQKQLLNLA
                     SIMAMHPDMLILDEPTSQLDPIAASDFLETVKKINRDLGTTIILTEHRLEEVFPSADRV
                     VVMDEGQILCVGTPPEIGEELKKRNHEMFLAMPVPMQVYAKVESEQPCPITVRDGRKWL
                     DIVCKKKGISPANASSSYRKESDSQKGKSSFSKITEKFTEKFKEKKEDIILACDDLWFR
                     YDKELPDVVKGLSFSLKRGEFFALLGGNGTGKSTTLSLLSRLRKPYRGKVLLEGKDIRR
                     YSDKELFRNFLGVLPQNPQSLFVKKSVELELFEMVGGVKEKKDEEYQLAMDKKDAVEGI
                     IKVTHLEELLHRHPYDLSGGEQQRLALAKILLLRPKLLLMDEPTKGLDSYFKKEFAGIL
                     ALLKEQGVTVFMISHDIEFCASYADRCGLFFDGNIVACGTPGEFFAGNNFYTTAANRMA
                     RRYFPMAVTGEDVVKCLKKGV"
     CDS             complement(9571..10512)
                     /locus_tag="ctg11_10"
                     /transl_table=11
                     /translation="MKDTFSTYHPVLNMLYFCGTIGVTMFVVHPVILAISFICAVAYSV
                     VLKGWKKTVKFNLLFSLPMMIIVALINPMFNHYGVTIIGYLHNGNPFTLESCVYGLVMA
                     VMLVCTLVWFSCYTVVMTSDKFIYLFGRIIPALSLVLSMCLRFVPKFIKEASVISDGQK
                     CVGRSVENGSLIKRAKHGITIFSILVTWSLENAIETSDSMKCRGYGEKGRTAFSLYHFD
                     KRDFLCLIFMIITFGAAIWGFSKGYAFCSYNPRIVVKGVPFTAGSLLVFAAFLLFSIMP
                     AAMEILDRRMWKARRGQVESASPAGYRLWEVE"
     CDS             complement(10589..11911)
                     /locus_tag="ctg11_11"
                     /transl_table=11
                     /translation="MKKKGFMRVVLALLMSMLLIVSTGCGKSGNGGSSSGKKSGKTATL
                     ADMNEIPEDGIITKEQFKTVAGDNKKVQFKGTTDDGITYIWTYDCSKIQNPADQNLKID
                     FSEKGLDDLKKQANNANDALKMTMYGKGLICVPDLEVQLPEAWQSNSAYLVKEQAGKLA
                     RMSDVVVTAQAEEDSSKKKDTSASQKDSSDKVKEATTAAKKDTKPQKGTTSLKMSVTSL
                     DGDCYIIGGITEQQNKGASAANKAENGTTNSESEGSDESGNSGENSYNEEGSSGSGDVS
                     DGGASSSGSSGKQDVANDEEVSGSSHTCTISISCATILNNMSDLKSGKEEFVPSDGWIL
                     AASEVEFTEGESVHDVLQRVCKDAGIQMESSFTPAYNSAYVEGINNLYEFDCGQLSGWM
                     YNVNGWFPNYGCSKYTVQDGDVINWVYTCNLGKDVGDNSMY"
     CDS             complement(12004..12324)
                     /locus_tag="ctg11_12"
                     /transl_table=11
                     /translation="ASKSATGTTAKKKDTAVEATTGSWNFSGEDYVPDTYAADETDAAE
                     ADTTAEKDNDTSKIVAGLGIFYIVKRICAIAVVVIIAFILYKKRHRIASALRNFQKGGD
                     KE"
ORIGIN
        1 gtatagtgtg tatgaagctc gataggaatg tctgttgcct gctttaatgc agttgcaagc
       61 cgcgttgcct aattcggtac tacaagacct gccatatctt tgatacagat agaatctgct
      121 cccatctctt caatattctt agcagtcttt ttccagtagt ctaatgtata tgcatcaccg
      181 attgtatagg aaagggcgat ctgcgcgtgt cctccctctt tctttgttgc atctacagca
      241 gtctgtaagt ttctaaggtc atttaaacag tcaaaaatac gaataacatc aattccgttt
      301 gcaatagatt tctgtacgaa atattctaca acatcgtctg gatatggctt atatcctaag
      361 atgttctgtc cacggaataa catctgtaac tttgtattct taaagccatc tcttaattta
      421 cgaagtctct cccatgggtc ttcctttaag aaacgcagac aggcatcaaa tgttgcacct
      481 ccccagcatt ctactgcatg ataaccaacc tgatccatct tatctacgat tggcagcatc
      541 tcctctgttg tcattcttgt agcaatcaga gactgatgtg cgtcacggag aacagtttca
      601 acgattttaa ctggtttttt cttaatttca gccataattt ctcctctttt atttcaaatc
      661 acgtaatgaa ttactcttat aaaatcatta tcaaatctaa cgattattta tacaccaaaa
      721 attgccataa aagttccggc tgctacagcc gtaccgataa ctccggcaac gtttggtccc
      781 atcgcatgca tcagcaggaa gttcgatgga tcggcatccg ctccaacctt ctgggataca
      841 cgagctgcca taggaacggc agatactccg gcagaaccga tcagtggatt tacctttcct
      901 ccggtaacct tacacataag ctttccgaaa agaacaccgg ctgctgtacc aactgcaaaa
      961 gctacaagac ctaatactac gattttgatt gtgttgacat ttaaaaacgc ttctgcactt
     1021 gttgtcgcac caacggatgt accaagaata ataactacaa tatacataag agcgttagat
     1081 gctgtctctg aaagctgttt tactacaccg gattctctga aaagattacc aagcatcagc
     1141 ataccaacta atggtgctgt tgtaggaagg atcagacata caacaactgt tacaacgatt
     1201 gggaacataa tcttctctgt ctttgtgacc gttcttaact gttccatctt aatctgacgt
     1261 tccttttctg tagtaaggag cttcatgatc ggtggctgaa taattggtac aagtgacata
     1321 taagaatatg ccgctaccgc aattggtccc attaagtctg tctgcccaag ctttccggca
     1381 aggaaaatag aagtaggacc atcggctcca ccaataatgg aaattgctgc tgctgccttt
     1441 ccgttaaatc ccataagcat tgcaaggaaa tacgcgctgt aaataccaaa ctgcgccgca
     1501 gctcccagca agaaacttgc tggattggca atcagcggac cgaagtctgt tagtgctcca
     1561 acgcctaaga aaatcagtga agggagaata ctccattcat ctaataagta aaaataatgt
     1621 aataatccgc cttcttccat aatggacgga tataagttaa ccagcagcat accaaaagaa
     1681 atcggcacta acaaaagtgg ctcatatcct ttggcgatgg ccagatataa gaagactaaa
     1741 gcaaccagta tcataatgaa gttacctggc tttaagaatg caaatccggt ctgtgctgcg
     1801 agattcgtca ttgtctctac aacataactc ataaatcttc ctccgtttta ttttgcaaat
     1861 atgctctagt tcattgtagc cagtacatct ccgccttcta ccatatctcc aactgctact
     1921 tccacacttg cgataacacc atcctgtgct gcacagattt cattctccat cttcatagcc
     1981 tctaatacaa gaacagcgtc gcccttcttt acagaagcac ctgcctgtgc ctttactgct
     2041 acgatcttac ctggcattgg tgctgtaatc tttacggcac cggcacttcc ggaagtcttt
     2101 ggggcagctt tcttagctgg agccggaacg gctgctggtg tacttaccgg cgctgcactt
     2161 gcttctcctg cacctaattc ttctactgct acatcataag caacaccatt aactgtaatt
     2221 ctataatttt tcattgtaaa tcctcctgaa tgattttatg tacttctaaa atctttctat
     2281 agctaacttt tcaaaacttt ataaaaagat tccaagaata catttttgct atcttctctt
     2341 cactctcttg attgaacgaa cgaccaactt atctgcactg actgctgctc ctccattcgc
     2401 tgccatgatt gccgctgtga ttactgcgac aagttcacca tcatccacaa gttcctcttc
     2461 ttccacaact tcttcaagaa tcggacgctt tggagccggt ctttcttcct gcgcagcctt
     2521 tttctctttc ttagaagaac gattctttaa cgctctttca atagatggga tatatacaaa
     2581 aagagaaatc agtaaagaaa tgaaaatcag tactgcaaat acagttccca tacccatcaa
     2641 agtatttaat aaggcttgtt caaatacgtt catactctca cctcactata ctgccgtatg
     2701 cttctttgtc actggagtta ctttctttcc gtaaagcatt tcataagcag cgataagacg
     2761 ctttcttgtt gcgtccggct cgatgatgtc atctatatat cctctctttg cagctgctaa
     2821 tgcactgctc tgtccttctg catattccgc agttttctct gcgataagtg ctgtcttatt
     2881 cttatctgta ttgatttcct ctgcatacat gatacgaact gcctgttctg catccatcat
     2941 tcctacagat gcctgtggcc atgccagaac aaagtcagct ccgatagctt tagaattcat
     3001 tacttccgct gcagttccat aagcctcgcc tgcaatgaga ttaatacgag gtacactaac
     3061 ctgtgcaagt gttgttgtaa acttcgctaa cgcgagcgcc tgctttctct cctcatgtgc
     3121 gttggcacga agtcctgtca cgttcgttac agtaagaaga ggaatcgaaa atgcatcaca
     3181 gaacttaata aatctttctg ctttttcaag accatttctt gttaaaacgg actcaccatc
     3241 tactggatgg ttagcaaccg cacctactgt ctctccattc agacggataa atgcagttac
     3301 catctctttg gcataggctg cctttgtctc tatgtacata ttgttgtcag aaatagattt
     3361 taaaatgtaa gcggcatcat atgcggcatc atttaactca ggaataaccc tatttaaatc
     3421 atcatcgtta tcaaagtaaa catcttctgc ttcataatca gaaggaagta catcaacgag
     3481 aatacgaagc tggtcaagaa gtccttcttc tgtctcacat acaaaatcta cgttaccagc
     3541 ctgctcagac tggaactgtg ctcctgccgt attctgacgg gattcttcat tccccgctaa
     3601 tgcattcgga ctgttgataa agagactgcc gttctccttc tccatcaatg taaaatcaga
     3661 catagcggac attacggcac ttcctcctcc acacattcca aatactgcag aaatctgtgg
     3721 aatcattcca gatgcctgtg cctgcttatt aaaaatcgtt ccaaatgcgt gaagggcatc
     3781 tgtcgcttcc tgtaatctaa gtcctgcaca atccagcatt ccaatgactg gcgcgcctgt
     3841 tttcatcgcc agatcataaa gggaagcaat tttcttcgca tgcatctcac ctacggaacc
     3901 tccaagtgcg gaagcatcct gactgtaaat ataaaccatg cggtcattaa taactccgta
     3961 tccagtgata acaccatcac cttctacttt ctttgcaccg agattataat cggtattacg
     4021 agcggaaaca tatccaccaa cttccacaaa actgtggtca tcaaacagat aatcaatgcg
     4081 ctctctggca ttcatttttg aattacccat attctttcct ccataaaaat gctatattgt
     4141 ataccttgtt gctctttcat tctatgtaat aataacaaat tattatcatg ttagcaacca
     4201 ttttctgtta gttatttaac atttatttta ttttgcccat tccactaaac aaaatgaaca
     4261 ttctgcctat ttgcaaattt tttaacaatt ctttcaattt tctttctgaa tctcctgttt
     4321 ttttcaggaa cgcttgtgta tttttcctgt ttttctctat tttatcttta aaattctatt
     4381 tttgttttat atgtccattt ttatttcgtt ataattttaa cgtattttga cattcaatta
     4441 ctagttggtt tttctatttt ttcgtcattt tatacaaaat attctcattc tatcaaatat
     4501 cttccgtttt tcttcataat ttcactctta tttccatcat tcttcttttc tcgcttatat
     4561 tctcctcctg tcttttttaa atcaaagata tagtatccaa aatcaatttt ggactatttt
     4621 tgtcaaactt ttttcacaaa ctaatagcac tccctttcat tttatacaac tgtatatgca
     4681 taccacgaag tattttcaaa aaatcagaaa gaaattataa actgtcaaga aaagcctgta
     4741 attttgcaca aatactcctt tattttttca cacaaaaaag gtataataaa caaaataaac
     4801 aattctttca caataaagga ggaggacatc ttatggaaaa ccgcaaaatt caatttcgtt
     4861 caaaagcctg taatctacat ctttctgcct atccgggaca tttcgcaaca aagcattctc
     4921 atgtcaacta ctttttagat atgacaacat taaaagtacg tcagtctaat gcagaagaag
     4981 ctgcaagagc gttagttcca ctttataaac ataataccgt cgtcgatacc atcgtatgtc
     5041 ttgacggaac agaagtaatc ggtgcatttt tagcagaaaa gcttacagag agcggattct
     5101 tctcttacaa ccagcataaa tctatctata ttgttactcc agaaatagat tcagatggtc
     5161 agatgttctt ccgcaaaaac atccagccaa tgattaaaga tagaaatatc attattttaa
     5221 tggcatctgt cacaactgga atcacaatca accgaagctg ggaatgtatc gagtactatg
     5281 gtggcaaact gcagggaatt tcagcaatat ttagtacgct ttctgaatat ggtaatcttc
     5341 ctgttaatgc gctgtttact ccaaatgata ttcctactta ccatacatat gataagcatg
     5401 actgcccata ttgtaagagt ggtcagaaaa tcgatgcttt ggtaaacgga catggatatt
     5461 ccgaattact ataactacta atttgtagat ttcgtataga cgaaaaaaag aaaccatacc
     5521 atatcccaga tgcggatgag cattttaaac acaacgacta cagagcagat gggatatggt
     5581 atggtttctt ttttcgtctg ttttccccta atgaatcgta atccatttca aaattttact
     5641 ttgggcttct acgaattgtt catattcttc ccggctgttt tgctgatatt ccagtgtgac
     5701 atactttggt gctacgcgct ctacaaattc ccggacacct tctccgataa aaggctgatg
     5761 cagatcaata tgacaggcat ggtcatatgc aaggcgaaat agttcataaa atggaatttt
     5821 atcaaagtct atcggatgtt ctctccattc ttttcgctgc tttcttacat aatcccctcc
     5881 aagtgacagc tgcaggtgca ttcctttgaa ccagtggagc atctgtgctt tttcgtattt
     5941 gtctatcatt ttattcagat atgctacggc atcttccgga gtctttagct gtgttgttgt
     6001 attcatataa tgcccggtat cgagcatgat tccctttttt tgtgtatgca ttccttctat
     6061 aagccggcgg gtaaggcgga catttttcaa ggtaagcccg ctccaccaga gattctctac
     6121 aagaaagtcg aatggatatt ctttttcatc aagtagggta ttgatgacct ctaagcttgc
     6181 atcaatcact tctttatctg tatagcggta tttataaata tagctctctc ggagtgtcac
     6241 ttctgaaaca tggaaaacta catactttgc tccaacttgt tctgcatagg caagatcgtc
     6301 ccgcaaactg ttcagataag attccctgct cattcctcca aagtattcca gccactgctc
     6361 tcttgaatca aattcctgat ctaggcgttc ataattcccc ttccaccagt ccatccagaa
     6421 aatatgaaaa tacagatgta ccccattcac catatccggc agaatctttc cttcatctgg
     6481 ctcgcctgcc cgaatcactt ccagtccatt taatcctcgt gactcataag actttctaat
     6541 atcttcacta tctttataac gatttagcat cccttcataa attgaaaaat tcatggaacg
     6601 acattctggt attttctgca tagtttcccc cttcaatctc gtatactctc agaatctttc
     6661 taagaataca ttttatctat acttatcatc catacttatt tcaaaaatgc cccatcattc
     6721 tggcaatctt tctaaagttc aaaaacgccc cggctattca tctcatcaga tcatatttta
     6781 tttttatccg ctgcagcttt tccaacaatg gctttgctcc aatccacaga aaaataaatg
     6841 tagaactggc atgaacaaga tctaccggaa tacctgaaat atagattgca agcagtcctt
     6901 cccatgtaaa atcatacaca ctcataaaga gagccgctgg attcatgatt cctccataaa
     6961 tgaacaccgt cacaaggaat ccatatatac aaaggctgag ccgtttggtc ggaagcagtc
     7021 ctattcggta aaggattcct gacaaaaatc cgataaaacc catcgcaaac atctgccatg
     7081 gggtccatgg tccctgccca aataagaaat tgctgactac catcgtcatg gcaccaacta
     7141 agaatcctgc ctcgccgcca aatgcgattg cactgatgat cacgattgct ataatcggct
     7201 taaagctcgg tatcataaaa aatgctgccc ggccggcggt tgccaatgct accattgttg
     7261 caagaacaac tagctctctc acctgaggtt ttcgtccctc aaataccata aaaaacggta
     7321 ataacgagta tataatgatt accaggctaa taaaataata ctttcttgga ccaaaaatct
     7381 tttcaaatac tgtgccaacg gcggcaacat ccataacata aaatccgaca gcaattgtga
     7441 ggggaatcgc tacaagcaag agaaagagac ttactctggt acgaacagaa agcctgcgtt
     7501 tttcctgctt tttccagatt tcggtatcca tctcaaacat atcattatct aaaatgacat
     7561 ctcccgccct gccttctcct gacaaatctc ctgctaattc ttttaaagca gaagctttcc
     7621 tgctttttgg taaaaagata cgctttatct ttgcagaaat cgtatcttca ttcacgattg
     7681 gagaagcgta aaattctttc aagaactcct gacttgattt ccagtctgcc attgttcaca
     7741 ctcctttttt aagacatttc acaacgtcct ccccggtaac cgccatggga aaataccttc
     7801 tagccattcg gtttgccgct gttgtataaa aattatttcc ggcaaagaat tctcccggag
     7861 ttccacatgc cacaatattt ccatcaaaaa acaaaccaca tcggtctgca taagaagcgc
     7921 agaactcaat atcatgagaa atcataaaaa cagttacgcc ctgctctttg agtaatgcca
     7981 gtattccggc aaattctttt ttaaaatagc tgtcaagtcc tttggtcggt tcatccatca
     8041 acaaaagctt tggccgcaat aacaaaatct tagccagggc aagcctctgc tgctctcccc
     8101 cgcttaagtc atacggatga cgatgcagta attcttccaa atgtgttact ttaatgattc
     8161 cttccaccgc atccttttta tccatggcaa gctgatattc ttcatccttt ttctctttta
     8221 caccgcctac catttcaaac agttctaatt ccacactttt ctttacaaaa agggactgcg
     8281 ggttttgcgg cagtactcca agaaaattgc ggaacagttc tttatcgctg taacgacgga
     8341 tatccttacc ttctaaaagt acttttccac gatatggctt tctcaaacgg ctcaaaagtg
     8401 aaagtgttgt tgacttcccg gttccatttc ctccaagcaa tgcaaagaat tctcctcttt
     8461 ttaaggaaaa gcttagtccc tttacgacat ccggcagttc tttatcatag cggaaccaca
     8521 gatcatcaca cgctaagatg atatcttctt ttttctcttt aaacttttct gtaaactttt
     8581 ctgtaatctt agaaaaagaa gattttcctt tttgggaatc actctctttt ctatatgaag
     8641 aagatgcatt tgctggtgaa atgccttttt tcttacaaac tatatccagc cactttcgcc
     8701 cgtcacgaac agtaatcggg cagggctgct ctgactctac tttggcataa acctgcatcg
     8761 gtaccggcat agctaaaaac atctcatgat tgcgcttctt taattcttct ccgatttccg
     8821 gcggtgtgcc aacacataaa atctgccctt catccatgac cactaccctg tcagcagaag
     8881 gaaatacttc ctctaaacga tgttccgtaa gaataattgt cgttccaaga tcacgattaa
     8941 tcttctttac tgtttccaaa aaatcagaag ctgcaatcgg atcaagctga gaggtcggct
     9001 catcaagaat cagcatatcc ggatgcatgg ccatgataga tgccagattc aaaagctgtt
     9061 tctgtcctcc agaaagttcc gatacatttt tataaaacca gtcctgaatc ccaaaataac
     9121 ttgccatttc cgctacccgg atacggatat ctgcgttact gtatccaagg ctttccaaac
     9181 caaatgccag ctcatgccac actttatctg tcacgatctg attatccgga ttctgtaata
     9241 catagccaat cctctgactc tgctcccggt tactcatctc cccgattgat actccctgaa
     9301 aaagaatctc tccttttcgc tttccatgtg gcgttagggg agtctttaaa tgtgtcagaa
     9361 gtgtactctt tccacatcca ctctttccgc aaagaacaag gaattccccg tcctccacct
     9421 gcaaagaaac atgatttagc gccctctttt tttcttctgg ataagcaaaa cacaaatcat
     9481 tgatttctaa tatactattt ttcttttctg acaaaccatt cgctgtcacc ctgcacctcc
     9541 aaacttgctt tttatctcct gtatatacgg ctattcaact tcccacaaac ggtacccagc
     9601 cggtgatgca ctttctacct gtcctcttct cgccttccac atccttcggt ctaaaatctc
     9661 catcgctgct ggcatgatac taaacaataa aaaagcggca aagacaagca ggctgcctgc
     9721 tgtaaagggt actcccttta caacgatccg aggattataa gaacaaaatg catacccctt
     9781 tgaaaagccc catatcgctg ctccgaatgt aatgatcata aaaataaggc acaaaaaatc
     9841 ccttttatcg aaatgatata aagaaaaggc ggttctgccc ttctctccat atccccggca
     9901 cttcattgaa tccgatgttt caatcgcatt ctccaaagac caggtaacca gaatcgaaaa
     9961 aattgtaatt ccatgctttg ctctcttaat aaggctccca ttctctacac ttcgcccgac
    10021 acacttttgc ccatcagaaa taacagatgc ttctttgata aacttcggta caaagcgaag
    10081 gcacatggaa agtactaaag aaagtgccgg gatgattctt ccaaaaagat aaataaactt
    10141 atctgatgtc ataacaactg tgtagcagga aaaccataca agagtacata ccagcatcac
    10201 tgccatcaca agaccgtaca cacaactttc taatgtaaac ggatttccat tatgaagata
    10261 tcctataatc gttactccat aatgattaaa catcggatta attagggcaa caatgatcat
    10321 catcggtaat gagaagagca gattaaactt tactgtcttt ttccatcctt ttaaaacaac
    10381 ggaatacgca acagcgcata taaatgaaat tgccagaatc acaggatgaa caacaaacat
    10441 cgtcaccccg atcgttccgc aaaaatacag catatttaaa acaggatgat atgtcgaaaa
    10501 tgtatctttc atctaaatca aatctccatt acatcaaatt tctattatat taaatcttta
    10561 ttatatcaaa tctctatttc atacatcctt aatacatcga attatctcca acatccttac
    10621 caagattaca tgtataaacc cagttgatca catcgccgtc ctgtaccgta tacttactgc
    10681 atccgtagtt aggaaaccag ccatttacgt tatacatcca tccggaaagc tgtccgcagt
    10741 cgaattcata cagattatta attccttcca cataagctga attataagcc ggtgtaaaag
    10801 aagactccat ctggattcct gcatccttac atacacgctg taatacgtca tgtacagact
    10861 ctccttccgt aaattctacc tcggaagctg ccagaatcca tccatcagaa ggaacaaatt
    10921 cttccttgcc actttttaaa tcactcatgt tattaagaat cgtcgcgcag ctgatcgaaa
    10981 tcgtacacgt atgggaagaa cctgaaactt cttcatcgtt tgcaacatcc tgcttgccgg
    11041 aagaaccaga agaagaagct cctccatcag aaacatctcc acttcctgaa cttccttctt
    11101 cgttataaga attctctcct gaattccccg attcatcact tccttccgat tcactgttcg
    11161 ttgttccgtt ttctgcctta ttcgctgcgc ttgctccttt attttgctgt tctgtaatac
    11221 ctccgataat ataacaatct ccgtccagag aagttacgct catttttaaa gaagtggttc
    11281 ctttctgtgg ctttgtatcc tttttggcag cagtcgttgc ttccttcacc ttatcagacg
    11341 aatccttctg tgatgcagat gtatcctttt tcttggaaga atcctcttct gcctgtgctg
    11401 ttaccacaac atcgctcatc cttgcaagct ttccagcctg ttcctttaca agataagcag
    11461 aattcgactg ccacgcttcc ggaagctgta cctctaaatc tggtacacag atcagccctt
    11521 tcccgtacat tgtcatcttc aatgcatcat ttgcattgtt tgcctgcttc tttaaatcat
    11581 caagaccttt ctctgaaaaa tcaatcttca aattctgatc tgctggattc tgaatctttg
    11641 aacagtcata cgtccagata tatgtaattc catcatctgt tgtcccttta aactgtacct
    11701 ttttattgtc tcctgcaacg gtcttaaact gttccttcgt aataattcca tcctccggaa
    11761 tctcattcat atccgcaagt gttgctgtct tgccggactt tttaccggaa gaacttcctc
    11821 cattaccgga ctttccacaa ccggttgaaa caatcaataa catactcata agcagtgcca
    11881 gaacgacacg cataaatccc tttttcttca taaatacttt ttccctttct ttgtatatcc
    11941 ttagctttaa ctctgctcac tatacacctt atttttcttt aaaaaacaga ttatcttttt
    12001 aatctattcc ttatctccgc ctttttgaaa attgcgtaat gcacttgcaa tcctatgacg
    12061 ctttttatat aaaatgaaag caataatcac taccactgca atagcgcaaa tccttttgac
    12121 tatataaaat atccctaaac cagccacaat ctttgaggta tcattatcct tttcggctgt
    12181 ggtgtccgct tccgctgcat ctgtctcatc cgccgcataa gtatccggta cgtaatcctc
    12241 tccgctaaag ttccagcttc ctgtcgttgc ctctactgcc gtatctttct tcttcgctgt
    12301 cgttcctgtt gcactctttg acgcag
//
