LOCUS       c00066_gnlPro..        15421 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JDOKOADA_66.
ACCESSION   c00066_gnlPro..
VERSION     c00066_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 18:52:25
            Original ID  :: gnl|Prokka|JDOKOADA_66
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15421
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15421
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2390:7458]"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2391..7458
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
     cand_cluster    1..15421
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /kind="single"
                     /product="Rnf_complex"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15421
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Rnf_complex"
                     /region_number="1"
                     /rules="(Complex1_51K and minimum(5, [FMN_bind, FeS, Fer4,
                     Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N, SLBB]))"
                     /tool="gutsmash"
     CDS             complement(65..523)
                     /locus_tag="ctg66_1"
                     /transl_table=11
                     /translation="MKCPFCGLDNTRVIDSRPADDNSSIRRRRLCDECGKRFTTYERVE
                     IMPLTVIKKDKTREPYDRSKMMSGILRACHKRPVSVEQIEQMVNKIENELFNLEYKEIE
                     SKQIGEVVMEHLKSLEQVAYVRFASVYREFKDVETFMNELKKMLDNNR"
     CDS             complement(594..845)
                     /locus_tag="ctg66_2"
                     /transl_table=11
                     /translation="MRFWELSNKDVINCKNGHRLGCVGDLEIDVCKLCITDFYVPTGGK
                     YCGCLGKKSEYKIPVGAVIRIGVDSILVDIDEKKCLVK"
     CDS             complement(1140..2081)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hydrolase_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg66_3"
                     /sec_met_domain="Hydrolase_4 (E-value: 8.9e-32, bitscore:
                     100.2, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAYQKFTGTYQSSDHINRIHYYIYEPETDLRAILQIVHDFGDFVE
                     RNENLIRFFTDHGVMVCGCDHIGHGRSSKKEDYGYFGSKNGWTYLVKNTKKLTHYMKRE
                     YPDTPYFIYGHGLGSLIVRMDCIYEKGINGVILSGTSGKQKYCWRKILLAALLKRIWGA
                     EHRSVYLEKDIEKRLNHRFLKEQDTYSWIAANEKIRREYSRIYSEHLPVTVAAYEDILK
                     MLALVSTRKWYRSVNEDIPILLLGGKEDPIGNGGKGILEVHRQLEDTRHWVELHLYEGM
                     RHNICDEVRRDEVYTDMLQWMKLHMNEEYELQ"
     CDS             complement(2391..3176)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FeS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Fer4"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Fer4_9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1020:4Fe-4S binding domain (Score: 31.4; E-value:
                     3.8e-10)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_4"
                     /sec_met_domain="Fer4_9 (E-value: 4.3e-11, bitscore: 32.9,
                     seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 3.9e-09, bitscore: 26.2,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 5.4e-09, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="FeS (E-value: 8.7e-11, bitscore: 31.4,
                     seeds: 364, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.3e-07, bitscore: 21.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSISGIILAAVVVGGTGLVISILLGIASEKFKVPVDEKEVAVREC
                     LPGNNCGGFAGCDALAKAIAAGEAPVGACPVGGQPVADKIASIMGVEAGAGEKQVAFVK
                     CAGTCDKAKSKYKYAGNEDCVSAMSVPGGGPKACSFGCTGFGSCVKVCDFDAIHVINGV
                     AVVDKEKCVACGKCVATCPKSLIELVPYAAPHKVQCNSKEFGKAVKEVCSAGCIGCKMC
                     TRVCEADAITVENNIAKIDYSKCTGCGKCAEKCPAKIIL"
     CDS             complement(3192..3767)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_5"
                     /sec_met_domain="Rnf-Nqr (E-value: 1.4e-66, bitscore:
                     213.8, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKELILLIISAAIVNNVVLSQFLGLCPFLGVSKKVETAGGMGAAV
                     IFVITIASLVTSLIYKFILAPLDLTYLQTIVFILVIAALVQFVEMFLKKSMPALYESLG
                     VYLPLITTNCAVLGVALNSVQYGYNILQSVVYGLGISIGFTIAIVILAGIREKMEYNDI
                     PESWQGMPIVMVTAGLMSIAFFGFSGII"
     CDS             complement(3782..4540)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_6"
                     /sec_met_domain="Rnf-Nqr (E-value: 1.4e-71, bitscore:
                     230.1, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNNSALERLYNGIIKENPTLVLILGMCPTLAVTTSAINGAGMGL
                     STTVVLMFSNMIISILRNFIPDRVRIPGYIVIIASLVTVVQFLLQGYVPALNDALGVYI
                     PLIVVNCIILGRAESYASKNGPVSSFFDGLGMGLGFTVSLTILGAFRELLGAGTIFGKT
                     ILSESFYTPITIFILAPGAFFVLACLVAARNKIMNRKVKNGEMEEIPAGCGDCSACGNS
                     CCSSKSFFDMSVDNKKEETKAASEEKAENK"
     CDS             complement(4542..5171)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FMN_bind"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_7"
                     /sec_met_domain="FMN_bind (E-value: 3.5e-23, bitscore:
                     72.1, seeds: 891, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSLVKDALKLVIITVVAGLVLGAVYGITKKPIADQEAKAQMEAY
                     KAVFPKASDFKDVDGFSEEAASKVIASYKNTVDGHESDVISSAVEAVDASGKALGYIFN
                     ITTSKGYGGDIQLTVGIQSDGTVSGYSVLSISETAGLGMKAKDDPSWGKQFAGKKADAF
                     SVVKDGSGSGDDAKIDAISGATITSKAVTGAMNSCLAYFQSLEGGN"
     CDS             complement(5171..6124)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: NQR2_RnfD_RnfE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_8"
                     /sec_met_domain="NQR2_RnfD_RnfE (E-value: 5.8e-123,
                     bitscore: 399.8, seeds: 472, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEQLYNVSANPHVRDKASTHSIMLDVIIALLPATLFGFWNFGVK
                     AIINTVICVAVCVLAEYVWQRCMHQKITIKDCSAALTGLLLALNLPPEVPFWIPVIGGL
                     FAIIVVKQLFGGLGQNFMNPALGARCFLLISFAGIMTNFSYNGFGGSFDATTSATPLAA
                     LKAGEVVNLKAMFLGNTAGTIGETSALLLLVGGVYLIAKKIISWRIPVCYIVTLGLFVL
                     LFGGHGFDMTYLAEQLCGGGLMLGAFFMATDYVTSPITPKGQIVFGILLGILTGIFRLF
                     GGSAEGVSYAIIFCNLLVPLIERVTTPTAFGKGGKK"
     CDS             complement(6145..7458)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Fer4"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: RnfC_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Complex1_51K"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: SLBB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_9"
                     /sec_met_domain="Fer4 (E-value: 8.7e-08, bitscore: 21.9,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="SLBB (E-value: 2.4e-16, bitscore: 49.5,
                     seeds: 67, tool: rule-based-clusters)"
                     /sec_met_domain="Complex1_51K (E-value: 6e-53, bitscore:
                     168.9, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="RnfC_N (E-value: 5.8e-42, bitscore: 131.9,
                     seeds: 53, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2e-06, bitscore: 18.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLLTFKGGLHPYDGKELSKDKPITEYLPQGELVYPLSQHIGAPA
                     VACVKKGDRVLVGQKIAEAGGFVSANIYSSVSGTVKKIEPRMTVSGNKVNSIIVENDGE
                     YETVSFQPVTEKTNEAIINAVKEAGIVGLGGAGFPTHVKLSPKEPEKIDTIIINAAECE
                     PYITADYRCMMEIPEQLISGLNIMLSLFPKAKGVIGIEDNKPEAIAKLTEMCKNESRIE
                     VAVLKTKYPQGAERSLIFAVTGRAINSSMLPADAGCIVDNVATAIAIHEAITLGKPLFE
                     RVVTVTGDAIKNPGNFKVKNGTNAAELVEAAGGFKSQPEKVISGGPMMGMALSTLDVPC
                     AKTFSSLLCFTKDEVAACEPSNCIRCGRCISVCPAGLMPTKLSEIADHGDFALFDELNG
                     CECVECGCCSYICPAKRRLTQSMKTGRREAMALRRKKK"
     CDS             complement(7784..8191)
                     /locus_tag="ctg66_10"
                     /transl_table=11
                     /translation="LHRNGLDSTKKSYKNDILLILFFLIIGIGAFAFMQLQGKSGAEVK
                     VSVNNKEYGIYSLDKNQTVTIGEDDWENILIIKDGKASMAKADCPDKICVNHAAISKKG
                     ETIVCLPHKVVVEVVDENGTQDGNQIDIISK"
     CDS             complement(8163..9185)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg66_11"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3e-29, bitscore:
                     92.0, seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILTIAIPSYNSMDYMRNCIESLLPGGEDVEILIVDDGSKDETP
                     AIADEYEAKYPGIIRAIHQENGGHGEAVNAGLRNATGFFYKVVDSDDWVDAEAYQKILA
                     FLKEAVKEEEPLDMLLSNYVYEKVGAKHKKVIQYHSILPENRYFGWEEIGHFHASQNIL
                     MHSVIYRTELLRSFQFELPKHTFYVDNIFVYWPLPYVKKMYYLDVDFYRYFIGRDDQSV
                     NEKVMISRIDQQIRVNKIMIDLYAKHESMLSCPQLKEYMLHYLETIQMVTSVLLMKMNT
                     SESEAMRDDLWHYLEEKSPDAYKILKSSVLGKFTKSHNKLSHKLTMGGYKIAQKWIGFN
                     "
     CDS             complement(9373..10662)
                     /locus_tag="ctg66_12"
                     /transl_table=11
                     /translation="MVKAIVGANWGDEGKGKITDMLAQDSDIIIRFQGGANAGHTIIND
                     YGKFALHTLPSGIFYGHTTSIIGNGVALNIPILFNELKEITSKGVPAPKILISDRAQIV
                     MPYHILFDEYEEERLAGKSFGSTKSGIAPFYSDKYAKVGFQVNELFEEEAVLREKIERV
                     IVQKNILLEHLYHKPLIDADELYNTLMEYKEMVAPYVCNVSAYLDKAIKEGKNILLEGQ
                     LGTLKDPDHGIYPMVTSSSTLAAYGAIGAGIPPYEIKKVVTVCKAYSSAVGAGAFVSEI
                     FGDEAQELRVRGGDGGEFGATTGRPRRMGWFDCVASKYGCRLQGTTDVAFTVVDVLGYL
                     DEIPVCTGYEIDGKVTTEFPVTNQLEKAKPVLEVLPGWKCDIRGIKKYEDLPENCRKYI
                     EFVEEHIGYPITMVSNGPGRDDIIYRGFEK"
     CDS             complement(10771..12441)
                     /locus_tag="ctg66_13"
                     /transl_table=11
                     /translation="LSSKDTKETNVLAQASILMVAGIVTRIIGVLYRSPVTSIIGDEGN
                     GYYSIAVNIYTMILLISSYSIPMAVSKVVSAKMAVHQYKIAHKVFKCALIYVLVIGGIA
                     SLITFFGASVLIPSNQPKAIPVLRILAPTIFFSGFLGVFRGYFQAHRTMIPTSLSQIVE
                     QVANAVISIGAAVFFIHAFAGGDADKIPVFGAMGSAAGIGAGVITGLLFMLFIYSCNKK
                     YFKKEIQKDDTGVDSSYKDIFRIIFMMVTPVILSTFVYNISTVVDQTLFMDIMGFKRMA
                     SETAASLYGVFSGKYWVLINVPIALANSMSTAMIPAISGSYELKDYKKCRGHVRQAIHF
                     TMVISIPAAIGMGALAYPIMEVLFPQKATIDLAVSILRTGCISIIFYALSTVSNGVLQG
                     IGKVNIPLRNAAVSLVLHVVLLTPLLYFTNLNLYALVFATMFYAFLMCLLNNLSVRKYL
                     GYHQEMKRTFMIPLLSSVIMGILCYVFYQGIYLILSGIFGSFIHLRILVFICLMISVGF
                     AVIVYFVLVLKLKGITEAELRNFPKGNMLVRMAKKSKLL"
     CDS             complement(12583..14016)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lyase_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg66_14"
                     /sec_met_domain="Lyase_1 (E-value: 1.7e-24, bitscore: 76.7,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYDKYQSPLSERYASKEMQYIFSPDKKFKTWRKLWIALAETEYEL
                     GLDSVTKEQIEELKAHADDINFDVAKAREKEVRHDVMSHVYAYGVQCPNAKGIIHLGAT
                     SCYVGDNTDIIIMTEALKLVRSKLINVIAELSAFAMKYKDLPTLAFTHFQPAQPTTVGK
                     RATLWLHDLMLDLEDLEYVISTMKLLGSKGTTGTQASFLELFNGDHETIRKIDGKIAEK
                     MGFDACYPVSGQTYSRKIDSRVLNVLSGIAQSAHKFSNDIRLLQHLKEIEEPFEKHQIG
                     SSAMAYKRNPMRSERIASLADYVMSDAMNPAFVASTQWFERTLDDSANKRLSVPEGFLA
                     IDGILDLYLNVVDGLVVYPKVIEAHLMRELPFMATENIMMDAVKAGGDRQELHERIRQH
                     SMAAGRVVKEEGKENDLLERIAADSAFGMTMEQLQAIMKPENFVGRSPEQTVEFITEYV
                     QPVLDENKDILGMKAEINV"
     CDS             complement(14134..15420)
                     /locus_tag="ctg66_15"
                     /transl_table=11
                     /translation="AVSDTNGPKKNIQVHKGMGLVNEVFSSENLEKLKGNISVGHVRYS
                     TAGSSTRENAQPLVLNYYKGTLALAHNGNLVNALELREELEKTGAIFQTTIDSEVIAYH
                     VAKERISSATAEEAVLAAMRKLKGAYSLIVMSPRKLIGARDPFGFRPLCIGKRDNTYFL
                     TSETCALDTVGAEFVRDVEPGEVVTLTPSGIVSNRELCFKDSSKQARCIFEYIYFARPD
                     AVIDGVGVYASRIKAGRFLAMDSPVEADMVVGVPESGNPAAQGYAMESGIPYGTAFIKN
                     SYVGRTFIKPKQSMRESSVQVKLNVLKDAVKGKRIVMIDDSIVRGTTCHRIVRMLKDAG
                     AKEVHVRISSPPFLHPCYFGTDIPSEDQLIAYGKTLDEIRDSIEADTLAYLGMERLKEL
                     NNGLPYCDACFSGNYPIEPPTQDIRGEQG"
ORIGIN
        1 cgaggccaca aatatgcttt atttattttc cagtgggcgt ctgtttagcc acacaagtta
       61 ttatttaacg gttattatcc aacatcttct tgagttcatt cataaatgtt tccacatctt
      121 taaactcacg gtaaacagaa gcaaatctca catacgcaac ttgctctaag gacttcaaat
      181 gctccatgac cacctcgcca atctgcttac tttcaatttc tttatattct aaattaaaaa
      241 gttcattctc tatcttattc accatctgtt caatctgctc tacagatacc ggacgtttat
      301 gacaggcgcg caaaattccg gacatcatct tagaacgatc atatggttct cttgttttat
      361 ctttttttat gacagtgagt ggcataatct ctactctctc atatgtagta aatctttttc
      421 cacattcgtc acaaagtctt cgccgtcgta tggatgaatt atcatctgca ggtcttgaat
      481 caattacacg ggtgttatcc aatccacaaa aagggcattt catatcttat cctccagtat
      541 ttctatctct tatgtttaca tttatcgtgc cggttattat accagaaaaa tagctatttt
      601 acaagacatt tcttctcgtc aatatctaca aggatactat ctacgcctat tcgaatgact
      661 gctccgaccg gaattttata ttctgatttt ttgccaagac aaccgcaata ttttcctcct
      721 gtaggaacat agaaatctgt gatacataat ttacatacat caatttctaa atctccaaca
      781 cagcctaagc gatgtccatt cttacaatta atcacatctt tattactaag ttcccaaaaa
      841 cgcatcaaaa aagccctttc ttttaaatta tgagggcttt cttaaaataa tgctatctat
      901 atgctattca tttattatct agagggtgtt tgaaaaatgc tttctgcaag atgtgcgtta
      961 caatttgtgg gagatttcgc ctgaatgagg gcggcgtagc gggctacgcc aactgaatga
     1021 aggcaaaata taccgcaaat tggggcgtgc agattgtagg aatgattttt caaacacgct
     1081 ctaggagcaa aatattgtga tcgtaatgga attataagtt ctttttatta taaatttctt
     1141 tattgcagtt catattcctc attcatatgc aatttcatcc actgaagcat atctgtatat
     1201 acttcatctc ttcgcacttc atcacaaata ttatgacgca tcccttcata taaatgcaac
     1261 tccacccaat gacgagtgtc ttctaactgc cggtgtactt ccaatatccc ctttccgcca
     1321 ttaccaatag gatcctcttt tccgccaagc aacaaaatcg gtatatcttc atttacggaa
     1381 cgataccatt tcctggtgga gactaatgca agcattttta aaatatcttc atatgctgct
     1441 acggtaacag gaagatgttc agaataaatc ctggaatatt ctcgtcttat tttttcattc
     1501 gcagcaatcc aggaatatgt gtcctgttcc tttaaaaaac gatgatttaa acgtttttct
     1561 atatcttttt caagatatac acttctgtgt tccgcccccc aaatcctctt caaaagggcc
     1621 gctaaaagaa tctttctcca acaatacttt tgtttaccgc tagtccccga caaaatcact
     1681 ccattaatgc ctttttcata gatacaatcc attcgcacaa tgagagatcc cagtccgtgt
     1741 ccatagataa aatacggtgt atctggatat tctcttttca tatagtgtgt cagctttttt
     1801 gtatttttta ccagataagt ccatccattc ttgctgccaa aatagccata gtcctctttt
     1861 ttagaagaac gtccatgccc gatatggtca catccgcaaa ccataacgcc atgatctgta
     1921 aaaaaacgaa tcaaattctc atttctctcc acaaaatctc caaaatcatg cacaatctgt
     1981 aaaatagcac gaagatctgt ctccggttca tagatataat aatgtattct gtttatatga
     2041 tcagaacttt gatatgttcc tgtaaatttc tgataagcca tacaaaagcc tcccgtcctc
     2101 tctgtatatg acagattcct tttctcaact actatacagg ataaatgtga aaaaagaaag
     2161 acaatctgtc ttgcattttc gttaagatag attgcctttt ctttcgtttt tattaagttt
     2221 cttacaataa actatattcc agaatatggc tgaaaaatta ctatagcaac ctatatttca
     2281 taacttgcaa caagtatttt caaagacata tgagaagaag aaaaaatctt ctccgtaaat
     2341 tcaagaatgc cggggcattc ttgaatttag catcaactaa atcatacaga ttaaagaata
     2401 atcttagcag gacacttctc tgcgcacttt ccacatccgg tacatttgct gtaatcaatt
     2461 tttgcgatgt tgttctcaac agtgatcgca tctgcttcac agacacgagt acacatctta
     2521 caaccgatac atcctgcgga gcatacttct tttactgctt taccaaattc tttggagttg
     2581 cattgtactt tatgaggagc tgcatatgga acaagctcga ttaaagattt cggacaagtt
     2641 gccacacatt taccgcaggc aacacatttt tctttatcaa ctacagcaac gccattgata
     2701 acgtgaatag catcaaagtc acaaaccttt acacagcttc caaaaccagt acagccaaag
     2761 ctgcaggctt ttggtccacc gccaggtaca ctcatggcag aaacacagtc ttcattacca
     2821 gcatatttgt attttgattt tgccttatcg caggttccgg cacattttac gaatgcaacc
     2881 tgtttttcgc ctgctccagc ttctacaccc atgatagaag cgattttatc tgctactggc
     2941 tgtccaccta caggacatgc tccaactgga gcttctccag cagcgattgc tttagcaagt
     3001 gcatcacaac cggcaaaacc accacagttg tttcccggaa ggcactctct tacagcaact
     3061 tctttttcgt ctaccggcac tttaaatttc tcggaagcaa tgccaaggag aatggaaata
     3121 acaagtccgg ttccaccgac aactactgcc gcaaggataa ttccacttat actcattttt
     3181 gtccctccta attaaatgat tcctgaaaaa ccaaagaatg caatagacat aagtccggct
     3241 gttaccatta cgataggcat accctgccag gactctggaa tgtcgttgta ttccattttc
     3301 tcacggattc cggcaaggat aacaatcgcg attgtaaatc caatagaaat accgagacca
     3361 taaactacag actgtaaaat attatatcca tactgtacag agtttaaagc tacaccaagt
     3421 acggcacagt ttgttgtaat cagtggaaga tatactccta atgattcata caaagctggc
     3481 atagatttct ttaagaacat ctctacgaac tgtacaagcg cagcgataac gaggatgaat
     3541 acaatcgtct gcaaataagt taaatcaagt ggtgcaagaa taaacttgta aattaatgat
     3601 gtcactaaag aagcaattgt aataacgaag attacggctg ctcccattcc accggcagtc
     3661 tctacctttt tggatactcc gaggaaagga cataatccta aaaactgact cagtactaca
     3721 ttgttaacaa tagcggcact gataattaat aatattaatt ctttcataat ccttcccctt
     3781 tctatttatt ctctgctttt tcttcagaag cagcctttgt ttcttctttt ttattgtcta
     3841 cagacatatc aaagaaactc ttgctcgaac agcaggaatt accgcaggca gagcaatcgc
     3901 cacatcctgc aggaatctct tccatctcgc cattctttac cttacggttc ataatcttat
     3961 ttcttgcagc tactaagcag gcaagtacaa agaaagcacc aggagcaaga ataaaaatag
     4021 taattggtgt gtagaaagat tcagataaga ttgtctttcc aaaaattgtt ccggcaccaa
     4081 gtaactcacg gaacgcacct aaaatagtaa gggatactgt aaatccaaga cccattccaa
     4141 gtccatcaaa gaaagaagaa acaggaccat ttttacttgc ataggattct gcacgtccta
     4201 aaataataca gttaactacg attaatggga tatatacacc aagagcatca tttaatgctg
     4261 gcacataacc ctgtaagagg aactgtacta ctgtaactaa ggatgcgata attacaatgt
     4321 atccaggaat acgaactcta tccggaataa aattacgcag aatagaaata atcatattgg
     4381 agaacattaa tactacggtt gtagaaagtc ccatacctgc accattgatt gccgatgttg
     4441 ttaccgcaag agtaggacac atacccaaga taagaactaa ggtagggttc tctttgataa
     4501 taccattata aagtctttct aaagcactat tatttttcat cttagttacc tccttctaat
     4561 gactggaaat aagcaagaca gctattcata gcacctgtaa ctgctttact tgtgattgtt
     4621 gcaccggaaa tggcatcaat ctttgcgtca tctccagaac cggaaccatc ttttacaaca
     4681 gagaaagcat ctgctttctt accggcaaac tgtttgcccc agcttgggtc atctttggct
     4741 ttcataccaa gacctgctgt ctcactgata gagagtacgg aatatccgct tactgttccg
     4801 tcagactgaa taccaacagt aagctgaatg tctccaccgt atcctttaga agttgtgata
     4861 ttgaaaatgt aaccaagtgc tttgccagaa gcatctactg cctctactgc agaagagata
     4921 acatcgctct catgtccatc aacagtattc ttataagaag caatcacttt agaagctgct
     4981 tcctcggaga atccgtcaac atctttgaaa tcacttgcct ttggaaatac agccttgtat
     5041 gcttccatct gtgcctttgc ttcctgatca gcaataggtt tctttgtgat tccgtatact
     5101 gcaccaagga caagacctgc aacaacagta ataataacaa gctttaaagc atcttttact
     5161 aaagaattca ttatttctta cctccttttc caaatgcggt aggagttgta actctttcaa
     5221 ttaatggtac taacaggtta cagaagataa tcgcatagga aactccctct gcggaaccac
     5281 cgaataaacg gaagattcct gtcaggatac caagtaagat accaaataca atctgtccct
     5341 ttggtgtaat tggagatgta acgtaatctg tagccatgaa gaacgcacca agcattaatc
     5401 caccaccaca taactgttct gcaagatatg tcatatcaaa tccatgtcca ccgaaaagga
     5461 gaacaaaaag accaagtgta acaatataac atactggaat tctccagcta atgattttct
     5521 ttgcaattaa atatacacca ccgacaagca gtaagagtgc agatgtctca ccaattgtac
     5581 cagcagtatt accaaggaac atagccttta agtttacgac ttctcctgct tttaatgcag
     5641 caagaggtgt ggcacttgtt gtcgcatcaa aacttccacc aaatccatta taggagaagt
     5701 tggtcataat tcctgcaaaa gaaattaata agaagcaacg tgctccaagc gcagggttca
     5761 taaagttctg gcctaaacca ccaaaaagct gttttacaac gatgattgcg aataaaccac
     5821 cgataacagg aatccagaat ggtacttctg gcggaaggtt taatgctaat aataaaccag
     5881 taagtgctgc actgcagtct ttaattgtaa tcttctggtg catgcagcgc tgccatacat
     5941 attctgcaag aacacagaca gcaacacaga ttactgtatt gatgattgcc tttactccga
     6001 agttccagaa accaaataat gttgctggaa gaagagcgat aattacgtca agcataatgc
     6061 tatgtgtaga agccttatcc cttacatgag gattggctga tacgttatat aattgttcgt
     6121 tcattttttc acctctcctt atgtttattt cttctttctg cgaagagcca tcgcctcacg
     6181 acgacctgtc ttcatagact gggttaatct tctctttgcc gggcagatgt aagaacagca
     6241 tccacattcc acacattcac atccattgag ttcatcaaat aatgcgaaat ctccgtggtc
     6301 tgcgatttcg gaaagctttg taggcatcag gccggcagga catacggaaa tacaacgccc
     6361 gcaacggata cagttacttg gctcacaagc agccacttca tcttttgtga aacataaaag
     6421 agaagagaat gtctttgcac aaggaacatc taatgtagat aaagccatac ccatcatagg
     6481 cccgccagag attacttttt ctggctgaga cttaaatccg cctgctgctt ctactaattc
     6541 tgcagcattt gttccgttct ttactttaaa gtttccagga ttcttaatcg catctcctgt
     6601 tacagttact actctctcaa agaggggttt tccaagtgta attgcctcat gaatcgcaat
     6661 cgcagttgcc acgttatcta caatacatcc ggcatcggct ggaagcatgg aagaattaat
     6721 ggcacgacct gttactgcaa atattaaaga acgctctgca ccctgtggat actttgtctt
     6781 taatacagct acttcaatac ggctctcatt tttacacatt tctgtcaact ttgcaatcgc
     6841 ctctggctta ttatcttcga ttccgattac acccttagct ttagggaata aggaaagcat
     6901 aatattaaga ccagaaataa gctgttccgg aatctccatc atacaacgat aatcggcagt
     6961 gatgtatggc tcacattctg ctgcgttgat aataattgta tcaatttttt ccggttcctt
     7021 tggggaaagc tttacatgcg tagggaatcc ggcaccaccg agtccgacga tacctgcttc
     7081 ttttactgca ttgatgattg cttcatttgt cttttctgtt actggttgga aggaaacagt
     7141 ttcgtactct ccgtcattct ctacaataat ggagttcact ttgttaccag aaactgtcat
     7201 tcttggttca atctttttta ccgttccaga aacagagcta tagatgttgg cagaaacaaa
     7261 tcctccagcc tccgcgattt tctgaccgac taaaactctg tcacctttct ttacacaggc
     7321 aacggcagga gcaccaatgt gctgacttaa agggtatacc agctctccct gtggtaaata
     7381 ttcagtaatt ggtttgtcct tacttaactc tttaccatca tacggatgaa ggccaccttt
     7441 aaatgttagt agtcccattt ttttaccttc tttctaaaat tttttaaatc aaatagtgca
     7501 tgcatatttt tgtaagttct cacataaatt cttacgaaag catttcaata tttgatataa
     7561 aatcattaat aataatataa gaaaaaaagg gcgaaatcaa gaatcgtcat tttcttaacg
     7621 attagcaact tcgccatttc ccatatttta tataaaaaaa cttcgctatt atgcaattat
     7681 ttgcaatttt tttgtgtagt tttacaatac tgtatttaaa atagaacaat attgtatgca
     7741 atccaatcta ttattgttaa ataataaatt atatcaactg atgttattta ctgataatat
     7801 ctatctgatt cccatcctgt gttccattct catcaacgac ttccacaacc actttatgag
     7861 gaagacagac aatggtctct ccctttttac taatcgctgc atgattgaca caaattttat
     7921 ctgggcagtc tgcttttgcc atactggctt ttccatcctt tatgataaga atattttccc
     7981 agtcatcttc accgattgta acagtctggt ttttatctaa agagtatatt ccatattcct
     8041 tattattaac actgactttt acctctgctc cgctctttcc ctgaagctgc ataaaagcaa
     8101 aggcaccaat accaataatc agaaaaaaca gaatcagcaa aatatcgttt ttataagact
     8161 tcttagttga atccaatcca tttctgtgca atcttatatc ctcccatcgt gagtttatga
     8221 ctcagcttat tgtgggactt agtaaacttt ccaagaacag agctttttaa tattttataa
     8281 gcatctggag atttttcttc aagataatgc cataaatcat ctcgcatcgc ctctgattct
     8341 gatgtattca tcttcataag aagcacagag gttaccatct gaatcgtctc aagataatga
     8401 agcatatatt ctttaagctg tggacatgag agcatgctct catgctttgc ataaaggtca
     8461 atcataatct tattcacacg aatctgctgg tcaattcttg aaatcattac cttttcattg
     8521 acagactggt catcacgccc aataaaatac cgataaaaat ctacgtcaag ataatacatc
     8581 ttcttaacgt atggcaatgg ccagtataca aaaatgttat ctacataaaa tgtgtgtttt
     8641 ggtaattcaa actgaaaact ccgaagcagc tctgtacggt aaatcaccga atgcatcaaa
     8701 atattctggc tggcatggaa atgtccaatc tcttcccatc caaagtaacg attctccggc
     8761 agaatagaat gatactggat aaccttttta tgctttgctc caaccttctc gtaaacatag
     8821 tttgaaagca gcatgtcaag aggctcttct tctttcactg cctcttttaa aaaggcaagt
     8881 atcttctggt aagcttctgc gtctacccag tcatcactgt ctactacttt ataaaagaat
     8941 ccggttgcat tacggagtcc ggcattcact gcctctccat gtccaccgtt ttcctgatga
     9001 atcgcacgaa taatacccgg atatttcgcc tcatattcat ctgcgattgc aggagtctca
     9061 tcttttgaac catcatcaac aatcaatatc tctacatctt ccccacctgg aagaagactt
     9121 tcaatacagt ttctcatata atccatagaa ttgtaacttg gaattgcaat tgtcaggatt
     9181 ttcatgaatt acctcctttg gtatcctata tacttttaga atctttctgt tcctgcttta
     9241 gtacgaaaaa ttctcccagt caaaaagcaa acctagagcg tgtttgggaa atcattcctg
     9301 caatctgcac atcttacaga aaacattttt caaacacact ctagaaagat tcctaagagt
     9361 atatttattt aattatttct caaatccgcg gtagatgata tcatctcttc ccggaccgtt
     9421 agaaaccata gtaataggat atccaatatg ttcttctaca aactcgatat atttacggca
     9481 gttctctggt aaatcttcgt acttcttaat tccacgaatg tcacatttcc atcctggaag
     9541 tacttctaat acaggttttg ccttctctaa ctgatttgtt acagggaatt ctgttgtcac
     9601 cttaccatca atttcgtagc ctgtacatac aggaatctcg tcaaggtatc caagtacatc
     9661 tactacagtg aaagcaacat ctgttgttcc ctgaagacgg catccgtatt tagatgcaac
     9721 acaatcaaac caacccattc ttcttggacg tcctgttgtt gctccaaatt ctccgccgtc
     9781 accaccgcgg acacgaagtt cctgtgcctc atcaccaaag atttcactta caaatgctcc
     9841 agcacctact gcactactgt atgccttaca tactgtaaca actttcttaa tctcatatgg
     9901 aggaatacct gctccgatcg caccatatgc tgctaatgta gaagaagatg ttaccattgg
     9961 ataaattccg tgatctggat cctttaatgt tcctaactga ccctctaata aaatattttt
    10021 accttctttg attgccttat ctaagtacgc agatacgtta catacataag gagcaaccat
    10081 ctctttgtat tccattaatg tgttatacag ttcgtctgca tcaattaatg gtttgtgata
    10141 aagatgctct aataagatat ttttctgtac gataacacgc tcaatctttt ctcgaagtac
    10201 tgcctcttct tcgaataatt cgttaacctg gaaaccaacc ttcgcatact tatcagaata
    10261 gaaaggtgcg ataccagact tagtagaacc aaaagattta cctgccagac gctcctcttc
    10321 atattcatca aaaagaatat gataaggcat aacaatctgt gcacgatcag aaattaaaat
    10381 ctttggtgca ggaaccccct tagaagttat ctcttttaac tcattaaaaa gaataggaat
    10441 attcagtgct actccgttac cgataatact tgttgtatgt ccatagaaaa tacctgatgg
    10501 taatgtatgg agtgcaaact ttccataatc atttataatt gtatggcctg cattggcacc
    10561 accctgaaaa cggataataa tatcagaatc ctgtgcgagc atatcagtaa tcttaccctt
    10621 accttcatct ccccagtttg cgcctacgat tgcttttacc attagctcat tcctcccagc
    10681 tttaaaaact tactattttt atggatgtgg tttatcccat cacccaaaca cactaattat
    10741 aacttacttt gctttataag taaagaataa ttacaataac ttacttttct ttgccattct
    10801 gacaagcata tttcctttcg ggaagttacg aagttctgcc tctgtaattc cctttaactt
    10861 aagtaccaga acgaaatata cgataaccgc aaagcctact gaaatcatca agcatataaa
    10921 tacaagaatt cttaaatgaa taaaacttcc gaatattcct gataagatca agtagattcc
    10981 ctgataaaat acatagcaga gtattcccat aattacagaa gaaagtaatg gaatcataaa
    11041 tgttcgtttc atttcctgat gatatcctaa atacttgcgt acactcaaat tattcagcag
    11101 acacataagg aaagcataga acatcgtagc aaatacaagc gcatataaat tcaggtttgt
    11161 aaaatacaac aacggtgtaa gcagaacaac atgaaggaca agggaaaccg ctgcgttacg
    11221 aagcggaata tttacctttc caattccctg caatactcca ttacttactg tagacagtgc
    11281 ataaaatata atactgatgc agccagtgcg taaaatactt actgccagat caatcgttgc
    11341 tttttgtggg aacagcactt ccataattgg ataggcaagc gcccccattc caattgcagc
    11401 aggaatacta ataaccattg taaaatgaat tgcctgcctt acatgccccc tgcatttttt
    11461 atagtctttc aactcataac tgccggaaat tgcaggaatc atagcagtag acatagaatt
    11521 tgcaagcgcg atcggcacgt tgatgagcac ccagtatttt ccggagaaca cgccatataa
    11581 agaggccgct gtttcagaag ccattctttt aaatcccata atatccataa ataaagtctg
    11641 gtcaactacc gtactgatat tgtagacaaa cgtgcttaaa attaccggtg ttaccatcat
    11701 aaagataatc ctaaagatat ctttatagga actgtcaaca cccgtatcat ctttttgaat
    11761 ttctttttta aaatattttt tattacagga gtaaataaac aacataaata agagaccggt
    11821 tataacacct gccccaatac ctgcggcact tcccatcgca ccaaatactg gaatcttatc
    11881 ggcatcccca cctgcaaatg catgaataaa gaatacggca gccccgatac taatgactgc
    11941 gttagccacc tgctctacaa tctgagaaag cgaagtcgga atcatcgtcc tgtgtgcctg
    12001 aaaatatcca cggaataccc ctaaaaatcc ggagaaaaag atagttggag ctaaaatacg
    12061 aagtacagga atcgccttag gctgattcga aggaattaat acagaggctc caaaaaaagt
    12121 aataaggctg gcaatcccac ctattaccag aacatatata agtgcacatt taaatacctt
    12181 atgtgcaatc ttatactgat gtaccgccat cttggccgaa accaccttgg aaactgccat
    12241 aggaatacta taggaagata tcaataatat catcgtataa atattcacag caatactata
    12301 atatccatta ccttcatcac ctataatact tgtaaccgga cttcgatata atacaccgat
    12361 aatccttgtc acgatacctg ccaccatcaa tattgaagcc tgggcaagta cattcgtttc
    12421 ttttgtatct ttgctactca actgacaacc acctttccaa actttaaggg ttattctttc
    12481 tcctgttttt ataaattaca taacttaagg gttatcgttg ccgataaccc ttagtattat
    12541 acggatttct ttctagcatg tcaatccgaa gtttctgtat ttttatacat taatctctgc
    12601 tttcattcca agaatgtctt tattctcgtc aagaacaggc tgaacgtatt ctgtaatgaa
    12661 ctctactgtc tgctctggag atcttccaac aaagttttct ggtttcatga tggcctgaag
    12721 ctgttccatt gtcattccaa atgctgaatc tgctgcgatt ctttcaagaa gatcattctc
    12781 tttaccttct tcttttacaa cacgacctgc tgccatagag tgctgacgaa ttctttcgtg
    12841 aagttcctga cggtctccac cagcttttac tgcatccatc atgatatttt ctgttgccat
    12901 aaatggaagt tctctcataa gatgtgcttc aattaccttt ggatatacta caagaccatc
    12961 tacgacattc agatataagt caaggatacc atcaatcgca agaaaacctt ctggtacaga
    13021 aagacgcttg ttagcagagt catctaatgt tctctcaaac cactgtgtag atgctacaaa
    13081 tgccggattc atcgcatcag acattacata atctgctaaa gaggcaattc tctcacttct
    13141 cataggattt ctcttataag ccattgcaga ggaaccaatc tgatgtttct cgaatggttc
    13201 ttcaatttct tttaaatgct gtaaaagacg aatatcatta gagaatttat gagcagactg
    13261 tgcaattcca gaaagtacat taagtacacg gctgtcaatc ttacgggaat atgtctgtcc
    13321 ggaaactgga taacatgcat caaatcccat cttctctgca atctttccat caatcttacg
    13381 gattgtctca tgatctccgt tgaataactc taagaaactt gcctgagttc ccgttgttcc
    13441 tttagagcct aacaacttca ttgtgctgat aacatattct aagtcttcta aatcaagcat
    13501 aagatcatgt aaccataatg tagctctctt tccaacggtc gttggctgcg ctggctggaa
    13561 atgtgtgaaa gccagtgtag ggaggtcttt gtacttcata gcaaatgcag aaagctctgc
    13621 aatgacatta atcagcttgc ttcttactaa cttgagagcc tctgtcataa tgataatatc
    13681 tgtattatca cctacatagc aggatgttgc tccaagatgg atgattccct ttgcatttgg
    13741 acactgtaca ccatatgcat atacatggga cataacatcg tgacgtactt ctttctctct
    13801 tgcttttgcc acatcaaaat taatgtcatc ggcatgggcc tttaactcct caatctgttc
    13861 ctttgtcaca ctgtcaagac ctaactcata ttctgtctct gctaatgcga tccaaagctt
    13921 tctccatgtc ttaaacttct tgtctggaga aaagatatac tgcatctctt tacttgcata
    13981 tctttctgag agaggactct gatatttgtc gtacattgtt tatacctgct actaaaaaca
    14041 tatacaaatg tgtatatgct agatgatttg catctaaata gcttttcctt tcctgatttt
    14101 ttataattgc cacttgattt tctattagtt aatttatccc tgttctccac ggatatcctg
    14161 tgttggcggt tcaatcggat agttaccgct gaaacatgca tcacagtatg gaagtccgtt
    14221 gttaagttct tttaaacgtt ccattccaag ataagctaat gtatctgcct caatgctgtc
    14281 acgaatctca tctaaagtct taccataggc aatcaactga tcttcggaag gaatatccgt
    14341 tccaaaataa caagggtgta aaaatggagg agaactgatt cttacatgaa cttcttttgc
    14401 tccggcatcc tttaacatac gaacaatacg atgacaagtt gttcctcgaa cgatagaatc
    14461 gtcaatcata acaattctct taccctttac agcatctttt aacacattaa gctttacctg
    14521 tacactgctc tcacgcatgc tctgctttgg cttgataaac gttcttccaa cataagaatt
    14581 tttaatgaaa gctgttccgt aaggaatacc agattccata gcatatccct gtgctgccgg
    14641 attacctgat tcaggaacac caacaaccat atctgcttct accggtgaat ccatagcaag
    14701 gaatcttcct gccttaatac ggctggcata aacaccaacc ccgtcaatga ctgcatccgg
    14761 tcttgcaaaa tagatatatt caaaaataca tcttgcctgc ttagaagaat ctttgaagca
    14821 aagttcccta tttgatacaa ttccactcgg tgttagggta acaacttctc ctggttctac
    14881 atctcttaca aattctgccc ctactgtatc taaggcacac gtctcagatg taaggaaata
    14941 tgtattgtct ctcttgccga tacaaagagg tctgaaacca aatggatctc ttgccccaat
    15001 cagctttctc ggactcatta cgataagaga ataggctccc tttaacttac gcattgctgc
    15061 aagtaccgct tcttctgctg ttgcggaaga aattctctct ttggcaacat ggtaagcgat
    15121 tacctcagaa tcaatcgttg tctggaaaat agcgcctgtc ttttcaagtt cctcgcgaag
    15181 ttctaatgca tttaccagat taccattatg tgcaagagcc agcgtacctt tataataatt
    15241 cagtactaac ggctgtgcat tctctctggt actagaacct gcagttgaat accggacatg
    15301 acccacactg atatttccct ttaatttctc aaggttttca ctgctaaaca cttcgttgac
    15361 aaggcccatt cctttatgaa cctgaatgtt ctttttcggg ccgttggtat ccgaaactgc
    15421 a
//
