LOCUS       c00069_gnlPro..        13746 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JDOKOADA_69.
ACCESSION   c00069_gnlPro..
VERSION     c00069_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 18:52:25
            Original ID  :: gnl|Prokka|JDOKOADA_69
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 496
            Orig. end    :: 14242
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13746
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[10496:14242]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13746
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13746
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13746
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(841..1647)
                     /locus_tag="ctg69_2"
                     /transl_table=11
                     /translation="MSTYKIVFSDIDGTLLTSEHIVSTATIEAIASLQDKNIPFVIISS
                     RSASCIYPILEKHHFQCPIVACGGAWIEDMNGRILSNEGMSKQTAATVIEFMTEKKFDL
                     AWGIYSGKNWITNDRTDARILHEESVVEVESVEGTVALLPEDAVVNKILCMCNPACILQ
                     IEEDLKKAFPILSIVKSSNYLLEIMPAGMNKAKGIRKFCELFSIATEDSVAFGDNYNDL
                     EMLYAAGCGILMGNAPVAILETFPGKVTLDNNHDGIPVALKDLGLI"
     CDS             2013..2789
                     /locus_tag="ctg69_3"
                     /transl_table=11
                     /translation="MECRKELSGVKRREQIIDNLREHGEVTVKILSNQFGVSEMTIRRD
                     LHLLEEQGYATIHYGGAALLDRQNIGCQSFSLRKGKESENKRRIAKKAASFIREGDVLF
                     MDTSTTVLEILTYMPAFRVKIITNSMPVMESVYRDENIDLYMAPGLYRSVGGPLDYATA
                     EYLSRFHYNKAFFGSTSYEPDFGTSAAEEIEAAVKKCVIENSDENYLLIDHSKMGKRNF
                     VKWGDTDNYTAILSDEELDIDWRTKIARNGGKLILC"
     CDS             2870..3421
                     /locus_tag="ctg69_4"
                     /transl_table=11
                     /translation="MGKKVLIITGSPRLKGNTNALVTAFASGAVAAGNEVEVFDAATAN
                     LNGCHADKSCEQRGCCGQKDDGVRMNELMREADVLVLASPVYWSGFTSQIKTAIDRFYQ
                     FSFPKGRETLHIKDLYLIAASANPDSAMFNDVVHAYEQLCELLHFDKGGTLLCPGLAGA
                     DDLENHQEFLEKAVKMGMAI"
     CDS             complement(3659..4264)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg69_5"
                     /sec_met_domain="HAD (E-value: 1.9e-10, bitscore: 31.5,
                     seeds: 107, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIVCLDLEGVLVPEIWIAFAEETGIPELKRTTRDEPDYDKLMKY
                     RLNILKEHGLGLKEIQETIAKIDPIPGAKEFLDKLRELTQVIIISDTFSQFAGPLMKKL
                     GYPTIFCNSLVVADNGEITDFKMRCEKSKYTTVKALQSIGYDTIASGDSHNDLGMIQAS
                     KAGFLFKSTDAIKAEYPEIPAYETYDELYAAIKGVIEA"
     CDS             complement(4613..5026)
                     /locus_tag="ctg69_6"
                     /transl_table=11
                     /translation="MNHHTHFQQTQHFPYSYKKKIDAFVSADNIVSSYTGVFPVEKLGK
                     EPYYLAVAKGHKNLLNELNMSLSVIDGQDGLFLNELKNKYSSDTGVGMNETTVTIILPF
                     TIANAQKNSSAYGNGNADHLNNDEFTSLLLECV"
     CDS             5353..6231
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     85; E-value: 8.5e-27)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg69_7"
                     /sec_met_domain="LysR_substrate (E-value: 4.4e-31,
                     bitscore: 97.9, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 2.2e-27, bitscore: 85.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELRVLRYFLAVAKEQSFTRAAEQLHITQPTLSRQLAALEEELGS
                     VLFNRSGRNITLTEEGLLLKRRALEIIDLQEKIIDEFKGNEEEVEGVITIGCGEFAAVE
                     ILAQICKEYKKRYPLVQIALHTGTADMILEMMNKGLIDIGLFLEPISTEDLEYIRFQDS
                     DQWVISMRADDPLAKKEVITKEDLLRIPLILPERYSVQSEIANWFGKDFEKLNIAFISN
                     LGTNAGVMAIHGLGYPVSIQGAIRYWREDLLVQRKLYPEVKANTIMAWRRNLPQSKAIR
                     LFIDEINAFQA"
     CDS             6414..7181
                     /locus_tag="ctg69_8"
                     /transl_table=11
                     /translation="MAKIVQTAGRNALGEFAPQFAHFNDDVLFGENWNNGDIDVKTRSI
                     ITVVALMSQGITDSSLKFHLQNAKDHGVTQKEIAAIITHVAFYAGWPNGWAVFNLAKEV
                     WDVNEGDLPYEDEAMRAHAKEMVFPIGAPNDAFAQYFVGQSYLAPVSAEQVGIFNVTFE
                     PGCRNNWHIHHAKNGGGQMIICIAGRGYYQEEGKEAIEMKPGDCINIPAEVKHWHGAAP
                     DSWFSHLAVEIPGEETANEWCEAVSDEEYGKLK"
     CDS             complement(7348..7605)
                     /locus_tag="ctg69_9"
                     /transl_table=11
                     /translation="MNKFYKAIEEKIKASGYPREISGRDVYNDICDQIEDKENGTYLVL
                     SKFEDDVTFEYHITIQDEGFNLGVLTMRAPEGVFQTDFDE"
     CDS             7944..8360
                     /locus_tag="ctg69_10"
                     /transl_table=11
                     /translation="MKYLEGYMERHTEGEETDLHFLMIDLDDFKQINDTYGHVEGDRAL
                     IRIAGVLKKTLAGHAGILARYGGDEFCIAGEMLREETEQLIKNLYENLEKANKQADCPY
                     DIGMSVGCAQFTRKIIPAICTSQFAVYFAFIQLT"
     CDS             complement(8637..9278)
                     /locus_tag="ctg69_11"
                     /transl_table=11
                     /translation="MENRKIQFRSKACNLHLSAYPGHFATKHSHVNYFLDMTTLKVRQS
                     NAEEAARALVPLYKHNTVVDTIVCLDGTEVIGAFLAEKLTESGFFSYNQHKSIYIVTPE
                     IDSDGQMFFRKNIQPMIKDRNIIILMASVTTGITINRSWECIEYYGGKLQGISAIFSTL
                     SEYGNLPVNSLFTPNDIPTYHTYSKHDCPYCKSGQKIDALVNGHGYSELL"
     CDS             10001..11425
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_12"
                     /sec_met_domain="CT_Vparvula (E-value: 7.9e-138, bitscore:
                     450.1, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNSKMNARERIDYLFDDHSFVEVGGYVSARNTDYNLGAKKVEGD
                     GVITGYGVINDRMVYVYSQDASALGGSVGEMHAKKIASLYDLAMKTGAPVIGMLDCAGL
                     RLQEATDALHAFGTIFNKQAQASGMIPQISAVFGMCGGGSAVMSAMSDFTLMEKENGSL
                     FINSPNALAGNEESRQNTAGAQFQSEQAGNVDFVCETEEALLDQLRILVDVLPSDYEAE
                     DVYFDNDDDLNRVIPELNDAAYDAAYILKSISDNNMYIETKAAYAKEMVTAFIRLNGET
                     VGAVANQPVDGESVLTRNGLEKAERFIKFCDAFSIPLLTVTNVTGLRANAHEERKQALA
                     LAKFTTTLAQVSVPRINLIAGEAYGTAAEVMNSKAIGADFVLAWPQASVGMMDAEQAVR
                     IMYAEEINTDKNKTALIAEKTAEYAEGQSSALAAAKRGYIDDIIEPDATRKRLIAAYEM
                     LYGKKVTPVTKKHTAV"
     CDS             11438..11782
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_13"
                     /sec_met_domain="OAD_gamma (E-value: 7.3e-28, bitscore:
                     87.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVFEQALLNTLMGMGTVFAVLIFISLLISLFVYIPSIERALKNR
                     SSKKEKKAAQEERPAPKRPILEEVVEEEELVDDGELVAVITAAIMAANGGAAVSADKLV
                     VRSIKRVKRR"
     CDS             11877..12245
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 64.4; E-value:
                     2.1e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_14"
                     /sec_met_domain="Biotin_lipoyl (E-value: 5.4e-21, bitscore:
                     64.4, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNYRITVNGVAYDVAVEELGAGEASAAPVSTPAAVPAPAKKAAP
                     KTSGSAGAVKITAPMPGKIVAVKGQAGASVKKGDAVLVLEAMKMENEICAAQDGVIASV
                     EVAVGDMVEGGDVLATMN"
     CDS             12279..13403
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_15"
                     /sec_met_domain="OAD_beta (E-value: 1.5e-157, bitscore:
                     514.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVVETMTNLAAQTGFAFLKPGNFIMILVALVFLYLAIAKGYEP
                     LLLVPISFGMLLVNLYPSIMEEGGLLHYFYLLDEWSILPSLIFLGVGALTDFGPLIANP
                     ASFLLGAAAQFGIYSAYFLAMLMGFNGKAAAAISIIGGADGPTSIFLAGKLGQTDLMGP
                     IAVAAYSYMSLVPIIQPPIMKLLTTEKERQIKMEQLRTVTKTEKIMFPIVVTVVVCLIL
                     PTTAPLVGMLMLGNLFRESGVVKQLSETASNALMYIVVIILGTSVGATTSAEAFLNVST
                     IKIVVLGLVAFAVGTAAGVLFGKLMCKVTGGKVNPLIGSAGVSAVPMAARVSQKVGAEA
                     DPSNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             13561..13746
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_16"
                     /sec_met_domain="HMGL-like (E-value: 9.4e-13, bitscore:
                     38.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEIKKKPVKIVETVLRDAHQSLIATRMTTEEMLPIVDKMDQVGY
                     HAVECWGGATFDASLRF"
ORIGIN
        1 accgatattt ggatagtaat tcacatcttt tggttcaccg aataatccga cacaataatg
       61 aatattgtaa acattaatat cataaagtgc accgccataa tatgcaggat caaaagaatg
      121 tgtgatatct ccttctaaat atgcatcata tcggctggag tactgagaat aattacaaag
      181 agccatacga agcgtaccga gtttttcaac atttttcttc atttcgtaaa atacttcatt
      241 gtgaagaacc gttacagcct caaaaataaa taatttattc tcttctgcaa tctgctgcaa
      301 ttcctgtgcc tcattataaa agccagtaaa aggtttttca aggatgacat ttttcccgtg
      361 aagaagtgcc tgttttgcat aggaatagtg agcactgtta ataagaccga tataaaccgt
      421 atctgctgtg gtttctgtaa gtagtttttc atagtcagta taaacttcag cgatattata
      481 ctgttttgca aaagcctctg ctttttcttt actgtgaggt ctggcaaaaa tagctgtttt
      541 ttcaatctct tttattggtt cgattgcaaa taaggcatct gcaatgattt ttcctgttcc
      601 aataaatgca agtttcataa tataatctcc ttatattttt attaaagaaa gaattcctaa
      661 atacacttta gtttatcata gaatctaact tttggcaaag aaataaagat tgttacacat
      721 atttgtaatc tcggagcaaa ggttggatgc gagcaggtga gcgagcattc aatctgccac
      781 ggctaaagtt acaaatatga cgtagcaatc ttcccgtttt cctctgttca tcctaatgaa
      841 ttaaatcagc cctaaatctt tgagtgccac tggaattcca tcatgattat tatcaagagt
      901 aacctttccg gggaatgtct ccagaatagc aacaggagca ttccccatga ggataccgca
      961 accggctgcg taaagcattt ccagatcatt gtaattatct ccaaatgcca cggaatcttc
     1021 ggtagcaatg ctaaaaagtt cgcagaattt gcggatacct ttggctttat tcattccagc
     1081 tggcataatt tctaacaggt aatttgagga ttttacgatt gatagaatcg gaaatgcctt
     1141 ttttaaatct tcttcaatct gaagaataca cgcaggattg cacatacaga gtattttatt
     1201 aacgaccgca tcttccggta ataaagcgac agttccctct acgctttcca cttccacaac
     1261 actttcttcg tggagaatac gagcgtccgt tctgtcattt gtaatccagt tttttccgga
     1321 atagatgccc catgcgagat cgaatttttt ttctgtcata aattcgataa cagtagcggc
     1381 tgtctgttta ctcatgcctt catttgaaag aatccggccg ttcatatcct caatccatgc
     1441 gcctccgcat gctacaatcg gacattggaa atgatgtttc tctaaaatcg ggtaaatgca
     1501 gcttgcactt cgggaagaaa tgataacaaa aggaatattt ttatcctgaa gagaagcaat
     1561 tgcttcaatg gtagcggtgg atacgatatg ttccgatgtt aacagtgttc cgtcaatgtc
     1621 actaaaaaca attttgtatg tactcatatg tggtatctcc tttaataaaa ttagttatgt
     1681 ctttcaaaca cgctctagaa tatcattaaa aagaacagaa ataaacgttt gaatatgttt
     1741 tatttggcta aaaatggaat aaaaaatgtt tgataaaaca tttttgctaa ggtataataa
     1801 aaaatattta aattgtgata ttaaatcagt acagagagtt atattttgac aaaatacata
     1861 acttcagaca aaatacaaat aaatataaaa gtaaaaaata gtaaaattaa gatagcatag
     1921 ataaagagaa atatatagct aataattatg aaatgagaca gatggaagaa gctggctaat
     1981 tcataattat atataaaagg aaggaaaaat agatggaatg tagaaaagaa ttatctggag
     2041 taaagagaag agaacagatt attgataatc ttcgggaaca tggagaggtt acagtaaaaa
     2101 tattatctaa tcagtttggt gtttcagaaa tgacaatccg aagagatttg catttattag
     2161 aagaacaggg ctatgcgaca attcattatg gaggagcggc acttttagat agacaaaata
     2221 taggttgtca gagtttttct ttaaggaagg ggaaagaatc ggagaataaa agaagaattg
     2281 caaaaaaggc agcctctttt ataagggagg gagatgtact ttttatggat acaagtacaa
     2341 cagtacttga aatccttaca tatatgcctg catttcgggt aaaaatcatt acgaattcaa
     2401 tgccagtaat ggagtcagta tatagagatg aaaatattga tctttatatg gcaccaggat
     2461 tataccgttc tgtaggagga cctcttgact atgctacggc ggaatatttg tcccgttttc
     2521 attataataa agcttttttt ggttctacca gttatgagcc agattttggc acgtctgcag
     2581 cagaggagat tgaagcagct gtaaaaaaat gtgtgattga aaattcagat gagaattatc
     2641 ttttaattga tcattctaaa atgggaaaaa gaaattttgt aaaatgggga gataccgata
     2701 attatacagc tattctatct gatgaagaat tagacattga ttggagaacg aaaattgcac
     2761 gcaatggtgg aaaattgata ttgtgttaaa cttgtctttg ctgcgcaact cagaaattgc
     2821 ctttgtcatt ttgtggtggt ataatgtctt tataaaggag gagtaagaaa tgggtaaaaa
     2881 agtattgatt attacgggaa gtccaagact gaagggcaac accaacgcac tggtaactgc
     2941 atttgcaagt ggtgcggtag ctgcagggaa cgaggtagaa gtttttgatg cagcaactgc
     3001 gaacttaaat ggctgtcatg cagataagag ttgtgagcag cgtggctgtt gcggacaaaa
     3061 agatgacgga gtgagaatga atgaactaat gcgagaagca gatgttcttg tattggcatc
     3121 tcctgtctac tggagcggct ttacatcaca gattaaaaca gcgattgacc gcttttatca
     3181 gtttagtttt ccaaagggaa gagaaacttt acatatcaaa gatttatatc tcattgcagc
     3241 atctgctaat ccagattcgg caatgtttaa tgacgttgtt catgcctatg aacagctttg
     3301 tgagttactg cattttgata agggaggaac actcctttgt ccgggacttg caggagcaga
     3361 tgacctcgaa aatcatcagg aatttttaga aaaagcagta aagatgggga tggctattta
     3421 attcattaat aggctgacgc atccaaagag aaaagctgtc ctatatttgt gacctcgcag
     3481 aggtttgaat gctcgttcat gtacacgcac ccaaaccttg ctcagaggtc acaatatagg
     3541 gcagcttttc tctttgggat tgatagtgat tggatttagg caaacaaaaa tgagaacatt
     3601 taacatgccg cgatgaaagt cacagatagg aggggatagc tcgtctgtct atcacaaact
     3661 acgcttcaat tactccctta attgcagcat ataactcatc atatgtttca tatgccggaa
     3721 tttctggata ctcagcctta atagcatctg tactcttgaa taaaaatcca gccttacttg
     3781 cctgaatcat accaagatca ttgtgactgt ctccgctggc aatggtatca taaccgatgg
     3841 actggagagc tttaactgta gtatatttag atttttcgca acgcatttta aagtcagtga
     3901 tttctccgtt atctgctaca acgagagagt tacagaagat agtaggataa ccaagcttct
     3961 tcataagcgg gcctgcaaac tgggagaatg tatcactgat aatgataacc tgtgtcagtt
     4021 ctcttaattt atccaagaat tcttttgctc caggaatagg gtcaatcttt gcgattgttt
     4081 cctgaatttc ttttaatcca agaccatgtt cttttaaaat gttaagacga tacttcatta
     4141 acttatcgta atctggttca tctctggttg ttctctttaa ctctggaatt ccagtctctt
     4201 ctgcgaatgc aatccagatt tccggtacta atacgccttc taagtctaaa caaacaattt
     4261 ccatgtcttt gtttcctcca tttctgatgt gtcagttgcg gtatttaaca ataagtaaca
     4321 ctacaaaaca gtatgtaaaa taccacgtct tatctttcta gtaatgtgag tgtgtattga
     4381 aaatcatttt agtattttca aacacaatcg gatatggctc atgctagagc gtgtttgaaa
     4441 aatcattctc gcaaatgtga tgtgtaaatt actttttgct ttttcaaata ttctccagtt
     4501 aagttcaagc catattaaac actattatag taggaaacct gaaaaatctc cataaaaatt
     4561 tttatttttc aaaaattcta agaatttttt ggctgttgga gcgatatgtt tttcaaacac
     4621 actctagcag taaactagta aattcatcat tatttaagtg atctgcgttg ccattaccat
     4681 aggctgaaga attcttttgt gcatttgcga tagtaaacgg caggataata gtgacagtcg
     4741 tttcattcat gccgacaccg gtatcggaag aatatttatt ttttagttca tttaaaaaga
     4801 gaccatcctg accgtcaata acggagagtg acatatttaa ttcgtttaaa agattcttat
     4861 gtccctttgc aactgcaaga taataaggct cttttccaag cttttccaca ggaaatactc
     4921 ctgtgtaaga agagacaata ttatcagcac tgacaaaagc atcaatcttt ttcttataag
     4981 aatacggaaa atgttgtgtt tgctgaaaat gagtgtgatg attcatgtag aaggcctccg
     5041 atacgatata aaaggcaact gctaataaat ataaccgata taaaaatatg tatgtgaaag
     5101 atattagaaa ccgccataaa aattcaataa ttaatgctat aattctatca aaaatatgtt
     5161 aaaacttcaa cataaggact caaagaaatc gactttttta gacaatctgt gagtgaatgt
     5221 ctgctatgcg aatattcgct atcctttgat gaagcttctg tacttaagtg agttgtaata
     5281 agtatttttt tgagacaaat atatggtata cttttatata tttttacagt cttatgtaaa
     5341 ggggatatag gaatggaact acgagtatta cgctattttt tagcagtcgc aaaagaacag
     5401 agttttacaa gagcagccga acaattacat atcacacaac caacactttc aagacagctt
     5461 gcagcgttag aggaagaatt agggagtgtt ctttttaatc ggagcgggcg aaatattact
     5521 cttacagagg agggcctttt attaaaacgc agagcattag aaattattga cttgcaggaa
     5581 aagattattg atgaatttaa aggcaatgag gaagaagtag aaggagtcat taccattggc
     5641 tgtggcgaat ttgccgcagt agaaatactg gcgcagatct gtaaggaata caagaaaaga
     5701 tatcctcttg ttcagatcgc actccatact ggaaccgccg atatgatatt ggaaatgatg
     5761 aataaaggcc tgatagatat cggtctgttt ttggaaccaa tcagtacaga agatttggaa
     5821 tatattcgtt ttcaggatag cgaccagtgg gtgatcagta tgagagctga tgatccgctt
     5881 gctaaaaaag aagttatcac aaaggaagac ttgctcagaa tcccacttat tttaccagaa
     5941 cgatatagtg tgcagagtga gattgcaaac tggtttggaa aagattttga aaagcttaat
     6001 atcgcattta tcagtaatct tggaacgaat gccggagtca tggcaattca tggattggga
     6061 tatcctgtct ccatacaggg ggcaatccga tattggagag aagatttact ggtgcaaaga
     6121 aaactgtatc ctgaagtaaa agccaatacc atcatggcat ggcggagaaa cttaccccag
     6181 tcaaaggcaa ttcgtttgtt tatagatgaa ataaatgcct ttcaagcata aaaaaccata
     6241 caatataggt attagtcata ataggagaaa gaaattataa taagtacata agatatattt
     6301 attaaaagta tattttagat atttttgttt ggaaggtaac ggtttagcac atgaggcaat
     6361 gaatcgttct gtttaaaaat gatgaaaata gttattttag gaggtttttt attatggcaa
     6421 aaattgtaca gacagcagga agaaatgctt taggagaatt cgccccacag tttgcccact
     6481 ttaatgatga cgttcttttt ggagagaact ggaataatgg agatattgat gtaaagacaa
     6541 gaagtatcat cacagtagtt gccctcatgt cacagggaat taccgattct tctttaaaat
     6601 ttcatttgca gaacgcaaaa gatcatggcg taacacagaa agaaatcgca gcaatcatta
     6661 cacacgttgc tttttacgca ggttggccaa acgggtgggc tgtgtttaac ttagcaaaag
     6721 aagtgtggga tgtaaatgaa ggtgaccttc catatgaaga cgaggcaatg agagcacatg
     6781 caaaggaaat ggtattccca atcggagcac caaatgatgc atttgcacag tactttgtag
     6841 gccaaagcta ccttgcgcca gtttccgcag agcaggttgg aatcttcaac gtaacattcg
     6901 aaccaggctg ccgtaacaac tggcatatcc accatgcaaa aaatggcggt ggacagatga
     6961 ttatctgcat tgcaggccgt ggttactatc aggaagaagg caaagaagcc atcgagatga
     7021 aaccaggtga ctgcattaac attccagcag aagtaaaaca ttggcatggg gcagcaccag
     7081 atagctggtt tagtcatctt gcggtagaga taccgggaga ggaaaccgcg aatgaatggt
     7141 gcgaagcagt cagtgatgaa gaatacggta agttaaaata gtaatttgcc gcaggtaaaa
     7201 cagacgccca cacaacgata taagccatat tagtgacttt agtcgcggcg tgttgaatac
     7261 ccgcttaaag cgttcctgtc caacacttgc tccgaggcca caaatatggc ttatatatcg
     7321 ttctgcgagc taactttggc ttattattta ctcatcaaaa tctgtttgga agacaccctc
     7381 tggtgctctc attgtcaaaa ctccgagatt aaatccctca tcctgaatcg taatgtggta
     7441 ctcaaaagtc acgtcatctt caaatttgga taacactaga taggttccat tttctttatc
     7501 ttcaatctga tcacagatat cattatatac gtctcttcca gaaatctctc ttgggtagcc
     7561 ggatgctttt attttttctt cgattgcttt ataaaatttg ttcatggttt cctcgctttc
     7621 gtggttatgt tgttttaata tgataattta aaatagatgg tttgaaaagg gttttgtgcc
     7681 atgctataat aatagtagta tagaatattt gttttgctaa gacaatacca ttttgatgta
     7741 aaagttttaa taaaatagtg tcatgcaaaa ataatagaaa ttcgaaggac agaattaagg
     7801 gaatatttta tggtgtgatt ataccatttg tttatattta tatttttttg gtgacacttg
     7861 gaattattca ggtatttacg gcatttctta caaatagaat tacaatggat gaattaacgc
     7921 agattaataa ctgaacaaag ctgatgaagt atttggaagg atatatggaa agacatacag
     7981 aaggggaaga aacagattta cattttttga tgatcgatct tgatgatttt aaacagatta
     8041 atgatacata tggtcatgtt gaaggagaca gggcattgat aaggatagca ggggttttga
     8101 aaaaaacact ggcaggacat gcaggcattc ttgcaagata tggcggagat gaattctgta
     8161 ttgccggaga gatgcttcgg gaagagacag aacaactgat taagaactta tatgaaaatc
     8221 tggagaaagc gaataaacag gcggactgtc catatgatat aggaatgtct gttggctgtg
     8281 cacagtttac aagaaaaatc attcctgcaa tctgcacgtc ccaatttgcg gtatattttg
     8341 ccttcattca gttgacgtag cccgctacgc cgccctcatt caggcgaaat ctcccacaaa
     8401 ttgtaacgca catcttacag aaagcatttt tcaaacacgc tccaggtctt ctaaaaaaag
     8461 aattgttata agtttgattt tgttccgttg cgctaaacgc ttaattttgc ctaataaaac
     8521 aaacttgctc gaaaacgagc tcgcaaggtt atggtcaaaa ttccgcagca caaagtgaca
     8581 aaattcaaac ttataacaat tcttttttcg tctatacgaa atctacaaat tagtagttat
     8641 agtaattcgg aatatccatg tccgtttacc aaagcatcga ttttctgacc actcttacaa
     8701 tatgggcagt catgcttact atatgtatgg taagtaggaa tatcatttgg agtaaacagc
     8761 gaattaacag gaagattacc atattcagaa agcgtactaa atattgctga aattccctgc
     8821 agtttgccac catagtactc gatacattcc cagcttcggt tgattgtgat tccagttgtg
     8881 acagatgcca ttaaaataat gatatttcta tctttaatca ttggctggat gtttttgcgg
     8941 aagaacatct gaccatctga atctatttct ggagtaacaa tatagataga tttatgctgg
     9001 ttgtaagaga agaatccgct ctctgtaagc ttttctgcta aaaatgcacc gattacttct
     9061 gttccgtcaa gacatacgat ggtatcgacg acggtattat gtttataaag tggaactaac
     9121 gctcttgcag cttcttctgc attagactga cgtactttta atgttgtcat atctaaaaag
     9181 tagttgacat gagaatgctt tgttgcgaaa tgtcccggat aggcagaaag atgtagatta
     9241 caggcttttg aacgaaattg aattttgcgg ttttccataa gatgtcctcc tcctttattg
     9301 tgaaagaatt gtttattttg tttattatac cttttttgtg tgaaaaaata aaggagtatt
     9361 tgtgcaaaat tacaggcttt tcttgacagt ttataatttc tttctgattt tttgaaaata
     9421 cttcgtggta tgcatataca gttgtataaa atgaaaggga gtgctattag tttgtgaaaa
     9481 aagtttgaca aaaatagttc aaaattgatt ttggatacta tatctttgat ttaaaaaaga
     9541 caggaggaga atataagcga gagaagaaga atgatggaaa tatgagtgaa attatgaaga
     9601 aaaacggaag atatttgata gaatgagaat attttgtata aaatgacgaa aaaatagaaa
     9661 aactaactag taattgaatg tcaaaatacg ttaaaaatat aacgaaataa aaatgggcac
     9721 ataaaacaaa aatagaattt taaagataaa atagagaaaa acaggaaaaa tacacaagca
     9781 ttcctgaaaa aaacaggaga ttcagaaaga aaattgaaag aattgttaaa aaatttgcaa
     9841 ataggcagaa tgttcatttt gtttagtgga atgggcaaaa taaaataaat gttaaataac
     9901 taacagaaaa tggttgctaa catgataata atttgttatt attacataga atgaaagagc
     9961 aacaaggtat acaatatagc atttttatgg aggaaagaat atgggtaatt caaaaatgaa
    10021 tgccagagag cgcattgatt atctgtttga tgaccacagt tttgtggaag ttggtggata
    10081 tgtttccgct cgtaataccg attataatct cggtgcaaag aaagtagaag gtgatggtgt
    10141 tatcactgga tacggagtta ttaatgaccg catggtttat gtttacagtc aggatgcttc
    10201 cgcacttgga ggttccgtag gtgagatgca tgcgaagaaa attgcttccc tttatgatct
    10261 ggcgatgaaa acaggcgcgc cagtcattgg aatgctggat tgtgcaggac ttagattaca
    10321 ggaagcgaca gatgcccttc acgcatttgg aacgattttt aataagcagg cacaggcatc
    10381 tggaatgatt ccacagattt ctgcagtatt tggaatgtgt ggaggaggaa gtgccgtaat
    10441 gtccgctatg tctgatttta cattgatgga gaaggagaac ggcagtctct ttatcaacag
    10501 tccgaatgca ttagcgggga atgaagaatc ccgtcagaat acggcaggag cacagttcca
    10561 gtctgagcag gctggtaacg tagattttgt atgtgagaca gaagaagcac ttcttgacca
    10621 gcttcgtatt ctcgttgatg tacttccttc tgattatgaa gcagaagatg tttactttga
    10681 taacgatgat gatttaaata gggttattcc tgagttaaat gatgccgcat atgatgccgc
    10741 ttacatttta aaatctattt ctgacaacaa tatgtacata gagacaaagg cagcctatgc
    10801 caaagagatg gtaactgcat ttatccgtct gaatggagag acagtaggtg cggttgcaaa
    10861 ccagccagta gatggtgagt ccgttttaac aagaaatggt cttgaaaaag cagaaagatt
    10921 tattaagttc tgtgatgcat tttcgattcc tcttcttact gtaacgaacg tgacaggact
    10981 tcgtgccaac gcacatgaag agagaaagca ggcgctcgca ttagcgaagt ttacgacaac
    11041 acttgcacag gttagtgtac ctcgtattaa tctcattgca ggcgaggctt atggaactgc
    11101 agcggaagta atgaattcta aagctatcgg agctgacttt gttctggcat ggccacaggc
    11161 atctgtagga atgatggatg cagaacaggc agttcgtatc atgtatgcag aggaaatcaa
    11221 tacagataag aataagacag cacttatcgc agagaaaact gcggaatatg cagaaggaca
    11281 gagcagtgca ttagcagctg caaagagggg atatatagat gacatcatcg agccggacgc
    11341 aacaagaaag cgtcttatcg ctgcttatga aatgctttac ggaaagaaag taactccagt
    11401 gacaaagaag catacggcag tatagtgagg tgagagtatg aacgtatttg aacaagcctt
    11461 attaaatact ttgatgggta tgggaactgt atttgcagta ctgattttca tttctttact
    11521 gatttctctt tttgtatata tcccatctat tgagagagcg ttaaagaatc gttcttctaa
    11581 gaaagagaaa aaggctgcgc aggaagaaag accggctcca aagcgtccga ttcttgaaga
    11641 agttgtggaa gaagaggaac ttgtggatga tggtgaactt gtcgcagtaa tcacagcggc
    11701 aatcatggca gcgaatggag gagcagcagt cagtgcagat aagttggtcg ttcgttcaat
    11761 caagagagtg aagagaagat agcaaaaatg tattcttgga atctttttat aaagttttga
    11821 aaagttagct atagaaagat tttagaagta cataaaatca ttcaggagga tttacaatga
    11881 aaaattatag aattacagtt aatggtgttg cttatgatgt agcagtagaa gaattaggcg
    11941 caggagaagc aagtgcagcg ccggtaagta caccagcagc cgttccggct ccagctaaga
    12001 aagctgcccc aaagacttcc ggaagtgccg gtgccgtaaa gattacagca ccaatgccag
    12061 gtaagatcgt agcagtaaag ggacaggcag gtgcttctgt aaagaaaggc gacgctgttc
    12121 ttgtattaga ggctatgaag atggagaatg aaatctgtgc agcacaggat ggtgttatcg
    12181 caagtgtgga agtagcagtt ggagatatgg tagaaggcgg agatgtactg gctacaatga
    12241 actagagcat atttgcaaaa taaaacggag gaagatttat gagttatgtt gtagagacaa
    12301 tgacgaatct cgcagcacag accggatttg cattcttaaa gccaggtaac ttcattatga
    12361 tactggttgc tttagtcttc ttatatctgg ccatcgccaa aggatatgag ccacttttgt
    12421 tagtgccgat ttcttttggt atgctgctgg ttaacttata tccgtccatt atggaagaag
    12481 gcggattatt acattatttt tacttattag atgaatggag tattctccct tcactgattt
    12541 tcttaggcgt tggagcacta acagacttcg gtccgctgat tgccaatcca gcaagtttct
    12601 tgctaggagc tgcggcgcag tttggtattt acagcgcgta ttttcttgca atgcttatgg
    12661 gatttaacgg aaaggcagca gcagcaattt ccattattgg tggagccgat ggtcctactt
    12721 ctattttcct tgccggaaag cttgggcaga cagacttaat gggaccaatt gcggtagcgg
    12781 catattctta tatgtcactt gtaccaatta ttcagccacc gatcatgaag ctccttacta
    12841 cagaaaagga acgtcagatt aagatggaac agttaagaac cgttacaaaa acagagaaaa
    12901 ttatgtttcc gattgtcgta acagttgttg tatgtttgat tcttcctaca acagcgccat
    12961 tagttggtat gctgatgctc ggtaaccttt ttagagagtc cggcgtagta aaacagcttt
    13021 cagagacagc gtctaacgct cttatgtaca tcgtagttat tattcttggt acatccgttg
    13081 gtgcgacaac aagtgcagag gcattcttaa atgtcagcac aatcaagatt gtagtattag
    13141 gtcttgtagc ttttgctgtt ggtactgcag caggtgtcct gtttggtaaa cttatgtgta
    13201 aggttacagg tggtaaggta aatccattaa ttggttctgc cggggtatct gccgttccta
    13261 tggcagcccg tgtatcccag aaagttggtg cggaagcaga tccatcaaac ttcttactga
    13321 tgcatgcgat gggaccaaat gttgccggag ttatcggtac agcggtagcc gccggaacat
    13381 ttatggcaat ttttggagta taatttagaa ttatttgatt atttaaaatt cattatttat
    13441 agggctataa tctgtaaaaa atgttacagg ggatatttat aaatagttta caagttgaat
    13501 tttagataat aacagttgta agcgcaaata gttacgtgat ttgaaataaa aggagatatt
    13561 atggccgaaa ttaagaaaaa accggttaaa atagtagaaa ccgttctccg tgacgcacat
    13621 cagtctctga ttgctacaag aatgacaaca gaggagatgc tgccaatcgt agataagatg
    13681 gatcaggttg gttatcatgc agtagaatgc tggggcggtg caacatttga tgcttcactt
    13741 agattt
//
