LOCUS       c00014_gnlPro..        12095 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NEMGGLJB_14.
ACCESSION   c00014_gnlPro..
VERSION     c00014_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 18:33:02
            Original ID  :: gnl|Prokka|NEMGGLJB_14
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12095
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12095
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1584:12095]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [PFOR_II, POR, POR_N]) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /neighbourhood="10000"
                     /product="OD_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1585..12095
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [PFOR_II, POR, POR_N]) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /neighbourhood="10000"
                     /product="OD_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12095
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [PFOR_II, POR, POR_N]) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /kind="single"
                     /product="OD_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12095
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="OD_AA_metabolism"
                     /region_number="1"
                     /rules="(minimum(1, [PFOR_II, POR, POR_N]) and minimum(2,
                     [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG,
                     Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /tool="gutsmash"
     CDS             complement(88..1572)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_20"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:Dihydroprymidine dehydrogenase domain II, 4Fe-4S
                     cluster (Score: 69.9; E-value: 4.8e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg14_1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 7.4e-27, bitscore:
                     82.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_20 (E-value: 4.6e-23, bitscore: 69.9,
                     seeds: 204, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKPTGFLEYERKESVGEAPLKRIKHFNEFHTPLSKKEQERQGAR
                     CMNCGVPFCQSGILIKGMVTGCPLNNLIPEWNDATYTGNWDEAYNRLRKTNPFPEFTGR
                     VCPHPCEVGCTCNLGGDPVNIKEKELSIIERAYESGLIKPEPPEVRTGKTVAIVGSGPS
                     GLCVAEYLNRRGHSVTVYERSDRVGGLLMYGIPNMKLEKTYIERKVKLMEKEGVVFKTG
                     VNVGVDVKAQDLKKQYDAVVLCCGASNPRDIKAPGRKSKGIYFAVDYLKAATKSLLDSN
                     FADKKYIDAKDKNVMVIGGGDTGNDCVGTSIRLGCKSLIQLEMMPKLPDERQPNNPWPE
                     WPRVCKTDYGQEEAIAVFGKDPRVYQTTVKEFIANEKGEVCKAKLVKLESKFDKKAGRN
                     IMAEVAGSEYEVPVDLVLIAAGFLGSQPYVTKAFGLDLTERTNVKTVEGHFKTNVDKVF
                     TAGDMHRGQSLVVWAIREGRDCAREVDKALMGYSNL"
     CDS             complement(1585..6120)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: Glu_synthase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: Glu_syn_central"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_2"
                     /sec_met_domain="GATase_2 (E-value: 5.1e-173, bitscore:
                     564.2, seeds: 30, tool: rule-based-clusters)"
                     /sec_met_domain="Glu_syn_central (E-value: 1.2e-112,
                     bitscore: 364.6, seeds: 570, tool: rule-based-clusters)"
                     /sec_met_domain="Glu_synthase (E-value: 7.8e-154, bitscore:
                     500.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYQDNMRQGLYDPSLEHDNCGIGAVVNIKGLKSHETVSNALKIVE
                     NLEHRAGKDAEGKTGDGVGILVQISHKFFEKTCSTLGFSIGKERDYGIGMFFMPQDELQ
                     RNRAKKMFEIIVEKEGLNFLGWREVPVQPGILGKKAADCMPCIMQGFVKRPFDVPRGLD
                     FDRRLYIVRRVFEQSNDSAYVVSLSSRTIVYKGMFLVGQLRLFYNDLQDKDYESAIALV
                     HSRFSTNTVPSWEKAHPYRYIVHNGEINTIRGNADKMLAREENMESDYLKDEMIKLTPV
                     VDPNGSDSARLDNTLEFLLMSGMPLPLAMMITIPEPWENNEGMSREKRDFYQYYATMME
                     PWDGPASILFTDGDIMGAVLDRNGLRPSRYYITDDDQLILSSEVGVLDFDTTHIVKKER
                     LHPGKMLLVDTVKGELIDDEILKDSYVKNQPYGEWLSDNLVFLKDLKIPNVAVEEYSYE
                     ESNRLMKAFGYSYEEVKDSVLPMALNGSEAIGAMGVDTPLAVLSKRHHPLFDYFKQLFA
                     QVTNPPIDAIREEIVTSTSIYVGGEGNVLEEKAENCHVLKIHNPILTNTDLLKIRYAKV
                     KNINVKDVPITYYKGTPLDKAINHLYVAVDQAHKNGANVVILTDRGVDENHVAIPSLLA
                     VSAVHHHLIETKKSTSVSIILESGEPREVHHFATLLGYGACAINPYLAQFSIKKLIQDG
                     LLKKDYYAAVNDYNNAVLHGIVKIASKMGISTLQSYQGSQIFEAVGISKKVIDEYFTNT
                     VSRVEGITIEDIAEDVDYHHSKAFDMLGLKNDLSLDSEGDHKYRSGKEEHLYNPLTIHT
                     LQTAAWTNNYELFKQYTSMINKETSPVSLRGLMDFNYPSKGVPIEEVESVDSIVKRFKT
                     GAMSYGSISKEAHETLAIAMNMIHGKSNTGEGGEDLERLTVGPDGLNKCSAIKQVASGR
                     FGVTSRYLVSAQEIQIKMAQGAKPGEGGHLPAGKVYPWIAKTRHSTPGVGLISPPPHHD
                     IYSIEDLAQLIYDLKNANRNARISVKLVSEAGVGTVAAGVAKAGAQVILISGHDGGTGA
                     APRNSSIHNAGLPWELGLAETHQTLIKNDLRNKVIIETDGKLMSGRDVAMAAALGAEEF
                     GFATGPLITMGCVMMRVCNLDTCPVGIATQNPELRKRFKGKPEYVVNYMKFVAQEMREY
                     MAKLGVRTVDELVGRTDLLKELPEAKEYRLDLSAILNNPYVDKKHPICYNKKNEYNFEL
                     EKTLDEKVLLTKLKTALDKKQKRSISIDVGNTDRSFGTIFGSEITKKYYNTLEDDTFTV
                     QCTGAGGQSFGAFIPNGLTLELVGDSNDYFGKGLSGGKLIVYPPKGIRFKAEENIIVGN
                     VALYGATSGQAYINGVAGERFCVRNSGATAVVEGVGDHGCEYMTGGKVLIIGKTGKNFA
                     AGMSGGVAYVLDEDNDLYLSLNKEMVSSEPVVSKYDVMEIKDMITAHVAYTNSEKGKEI
                     LNDFSKYLPKFKKIIPHDYKKMLKKISEMEGKGLSAEQAQIEAFYEIKRG"
     CDS             6941..7030
                     /locus_tag="ctg14_3"
                     /transl_table=11
                     /translation="MLKFDTERRGHFAKKYAFIIIEKRKEKSQ"
     CDS             7027..7695
                     /locus_tag="ctg14_4"
                     /transl_table=11
                     /translation="MIINKFYEKLYKELINKLESDYILIPNTPENRKAINNTLTTVPCT
                     VKSLEKDSKIFKALSNKKAKAKQLSIVPKISKTLSLIIIATLICMPFNTINTLPTPTYH
                     PTVQVSILDISDGSSHQKGKNKLSEIQEQYTNKNQEQRNPKNYKKKVATNTYNTYKKQN
                     KFHLTLSTKKATQLLSTFKKFFLKTKNTYDNLSDAYDVISTLFVLISTVKESIRSKKLK
                     "
     CDS             complement(7799..9553)
                     /locus_tag="ctg14_5"
                     /transl_table=11
                     /translation="MLYKEDFGEGKNIEFKREIPKRHEKLLKDVIAFSNSTGGKIFIGI
                     EDKTNEVIGIGEKNPFRLADDISNMIFDSCTPIIDPEITIQTLEGRTVVVVEVFPGRMR
                     PYYLKSFGKEQGSYIRINDTSRPADDRKLKELELEGQKISYDTLPEIDMEYSEREAKIL
                     CNAMEKVAYDVQTTYVTRAIQETSLDPKQNTEKTEIINKMTIEKLEDLGLLCRIGKDLQ
                     PTHAFRLMTKNKIRYAKIQCALFKGTERDIFIDKREFDGPLYVQLENAYQFVLKHINLG
                     AKIEGLHRKEAYELPVRTIRELITNAVVHRSYLDESCIQVCVYDDRIEVTSPGMLYGGL
                     DIQSAKSGKSKCRNTAIAEAFRYMGLIEAWGTGIPRMIKECREYGLREPVFEELGDGIR
                     VTIFRENEELEMRKRAENIQNAENKYQYMNNINSENLASVVKEQTVEYREQNHCFNTEK
                     SLFNALDSQGNEKKYCLNDEKTLFETTSQDKTHCFETSVLTAENKYMLYKKLKELQVNK
                     SIGSVTALNIKEIIESFSGEEVFGRKEIKQKLGYKDSKAGFLIQTMREFELIKDVKGRG
                     KGKYCFDI"
     CDS             complement(9756..12095)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: POR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) EKR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_6"
                     /sec_met_domain="POR (E-value: 5e-36, bitscore: 113.1,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.9e-13, bitscore:
                     39.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_7 (E-value: 8.3e-12, bitscore: 34.4,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.7e-08, bitscore: 22.9,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 8.1e-05, bitscore: 12.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 7.9e-20, bitscore: 59.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="PEVKPAPITSAPGTVECKFWGLGGDGTVGANKNSTKIIGDHTDKY
                     IQAYFQYDSKKTGGVTISHLRFGDNPIRSPYYINQADFVACHNPAYVIQGMKMVQDVKP
                     GGVFMINCQWSDEELAHHLNADAKKYIADNNIQLYTINAIDKAIEIGMGKRTNTILQSA
                     FFKLADVMPIDKAIEYMKAAAKKSYSKKGDAVVEMNYKAIDAGVDAVHKVEVPESWKNP
                     EADAPKAERTGRPEVVKLVNELLDPIAKMDGDSLPVSAFADKADGQYVTGASAYEKRGT
                     AVTVPQWDPEKCIQCNNCAFVCSHATIRPFLLTDDEVKAAPDNMKVADMKPKAGAYKYT
                     MSVSPLDCMGCGECITVCPTAAISMQPQESQAAEQPVFDYLVANVSKKTDAGMVDTTPK
                     GSQFNQPLLEFSGSCAGCAETSYARLITQLFGEQMYISNATGCSSIWGNPAATSPYTVN
                     INSKKGPAWSNSLFEDNAEHGLGMEVGQRYLRDQAIELVKEIAASDKATAEFKAAADKF
                     LETKDDTKANVEPTTALIAELEKAAAAGCEKSKEVLAKKDYLGKKSVWIFGGDGWAYDI
                     GFGGLDHVLASGENVNVMVFDTEMYSNTGGQASKASNIGEVCQFAAAGKEISKKSLAEI
                     AMSYGYVYVAQIALGANPNQAVKCLAEAEAYNGPSLIIGYAPCELHGIAKGGMNHCQDE
                     MKKAVKAGYWNLFSFDPAKKAEGKNPFTLTSKEGDGSYQEFLNNESRYTRLIKPFPERA
                     ERLFNESEKVAKARYEHLQRLVELYK"
ORIGIN
        1 cgagtattca aaccgcagcg actaaagtca caaatatagg ttcttttatt tactgcgagc
       61 gtctctttgc ctgcggcaaa ccagaagtta cagatttgag tatcccatca gggctttatc
      121 aacttctctt gcacagtccc gaccttcgcg aattgcccat acaacaagtg actgtcctcg
      181 atgcatatca ccggcagtaa agactttatc tacatttgtc ttgaaatgtc cttctactgt
      241 ctttacattc gtgcgttctg taagatctaa gccaaaagct tttgtaacat atggctggct
      301 tcctaagaat cctgctgcga ttaataccaa atcaacaggt acttcatact cgctgccagc
      361 gacttctgcc atgatatttc ttccggcttt tttgtcgaat ttactttcaa gttttacgag
      421 ttttgccttg cagacttcgc ctttttcatt ggcaatgaat tcttttacgg ttgtctgata
      481 tactcgtggg tctttgccaa atacagcgat agcttcttcc tgaccgtagt ctgtcttgca
      541 gactctaggc cattctggcc atgggttatt tggctgacgt tcatctggaa gttttggcat
      601 catttctaac tgaatgaggc tcttacatcc taaacggatg gatgttccga cacagtcgtt
      661 tcctgtgtca ccgccaccga taaccattac atttttatct ttggcatcaa tgtatttttt
      721 atctgcgaag ttagaatcta aaaggctctt tgttgctgcc tttaagtaat ctactgcaaa
      781 ataaattcct ttgctctttc tgcctggtgc tttgatgtct cttggattag aggctccaca
      841 gcaaagtaca acagcatcat actgtttctt taagtcctgt gcttttacgt ctacaccaac
      901 gtttacgcct gtcttgaata caacgccttc tttttccatg agctttactt ttctctcaat
      961 atatgttttt tcaagcttca tgttaggaat tccgtacatg agcagtccac caacacggtc
     1021 ggaacgctcg taaacagtta cagaatggcc acggcggttt aagtattctg ccacgcagag
     1081 tccggatgga ccggaaccta cgatagcaac tgtctttcct gtgcggactt ctggtggttc
     1141 cggtttgatc aggccacttt cataagctcg ctctataata cttaactctt tttctttgat
     1201 gttaaccgga tccccgccta agttacaggt acatccgact tcacaaggat gtggacatac
     1261 acgacctgta aattctggaa atggatttgt ctttctaaga cggttataag cttcatccca
     1321 gttacctgtg taagttgcat cattccattc aggaatcaga ttattaagcg ggcatccggt
     1381 aaccattcct ttaatcaaaa taccggactg gcaaaatgga actccacagt tcatacatct
     1441 tgctccctgt ctctcctgtt cttttttgga caggggagtg tgaaattcgt taaaatgttt
     1501 gattctcttt aacggcgctt ctcccacgct ttcttttcgt tcatattcta aaaatccagt
     1561 tggttttccc atagcgctct cctcctatcc tcttttaatt tcgtaaaatg cttcaatctg
     1621 tgcctgctct gcgctaagac cttttccttc catttcggaa atcttcttga gcattttctt
     1681 gtaatcgtgt ggaatgattt tcttaaactt cggtaaatat ttgctaaaat catttaaaat
     1741 ttctttacct ttttcagagt ttgtatatgc cacatgggcg gtaatcatat ccttaatttc
     1801 cataacatca tatttagaaa caactggttc ggaagaaacc atttccttgt tgaggcttaa
     1861 gtataagtcg ttatcctcat caagaacgta ggcaacaccg ccgctcattc cggctgcgaa
     1921 gttctttcca gtcttaccga taattaagac tttaccacca gtcatgtact cgcatccgtg
     1981 atcgccgaca ccttctacaa cagctgttgc accggagtta cgaacacaga aacgttcacc
     2041 agccacacca ttaatataag cctgaccgct tgttgcaccg taaagtgcta cgttaccaac
     2101 gataatattt tcctcggctt tgaagcggat tccttttgga gggtaaacga ttaatttacc
     2161 accggataat ccttttccga agtagtcatt actgtcaccg acaagctcta atgtaagacc
     2221 atttggaata aatgctccaa agctctgtcc gccggctcct gtacactgta cagtaaatgt
     2281 atcatcttcc agtgtgttgt aatatttctt tgtaatttca gaaccaaaga ttgtaccaaa
     2341 ggaacggtct gtatttccaa catcgataga aatgcttctc ttctgctttt tatcaagcgc
     2401 tgtctttaac ttcgtaagaa gaactttttc atctaatgtc ttttctaatt caaagttgta
     2461 ttcattcttc ttgttgtagc agattggatg cttcttatct acatatggat tatttaaaat
     2521 agcagataaa tctaagcggt actcttttgc ttctggaagt tctttcagaa ggtctgtacg
     2581 tcctaccagt tcatctacag tgcggacacc aagttttgcc atgtattcac gcatttcctg
     2641 tgcaacgaac ttcatgtagt ttacaacgta ttccggttta cctttgaaac gttttctaag
     2701 ttccggattc tgtgttgcga tacctactgg acaagtatct aagttacaaa ctctcatcat
     2761 aacgcagccc attgtgatca gcggaccagt agcaaatcca aattcttctg ctccaagtgc
     2821 tgctgccatt gctacgtcgc ggccgctcat aagcttaccg tccgtctcga tgataacttt
     2881 attacgaagg tcatttttaa ttaatgtctg gtgtgtctca gcaagtccaa gctcccacgg
     2941 aagtccggca ttatggatag aagaattacg aggtgctgca cctgtaccac cgtcatgtcc
     3001 ggaaataagg attacttgtg cgccagcttt tgctacaccg gctgcgaccg ttccgacacc
     3061 tgcttcagat accagtttta cagaaatgcg ggcatttctg tttgcatttt tcaaatcata
     3121 aattaactgt gccaaatctt caatactgta aatatcgtga tgaggtggtg gtgagattag
     3181 tcctacacca ggtgttgaat gtcttgtctt tgcaatccaa ggatatactt ttcctgctgg
     3241 taaatgtcca ccttcaccag gttttgctcc ctgtgccatc ttaatctgaa tttcctgtgc
     3301 acttacaagg taacggcttg ttacaccgaa acgaccggaa gctacctgct tgattgcaga
     3361 gcatttattc agtccatctg gaccaactgt cagacgctct aaatcttctc caccttcacc
     3421 agtgtttgat ttaccgtgaa tcatgttcat cgcgattgcc agagtctcat gtgcttcctt
     3481 ggaaatagaa ccataactca tagcacctgt cttaaatcgt ttcacgatag aatctacaga
     3541 ttcaacttct tcgataggaa ctcctttgga tggataattg aaatccatta atccacgaag
     3601 acttactgga gaagtttctt tattaatcat ggaagtatac tgtttaaaca gttcataatt
     3661 atttgtccat gctgctgtct gtaatgtatg gatggtcagt ggattgtaaa gatgttcttc
     3721 tttaccactt ctatatttgt gatcaccttc actgtcaaga ctaagatcat ttttcagtcc
     3781 taacatatca aatgctttgg agtgatggta atctacatct tctgcgatat cttcaattgt
     3841 gataccttct acacggctta ctgtgtttgt aaagtactca tcaatgactt tcttgctgat
     3901 accaactgcc tcaaaaatct gagaaccctg ataggactgc agtgtggaaa tacccatctt
     3961 agatgcgatc tttacgatac cgtgaagtac tgcgttattg taatcattta ctgctgcata
     4021 gtaatctttc tttaataaac catcctgaat cagcttctta atactgaact gtgccagata
     4081 tgggttgata gcacatgcgc cgtaacctaa cagtgtggcg aaatgatgta cttctcttgg
     4141 ttcaccactc tctaagataa tacttacaga agtactcttc tttgtctcaa tgagatgatg
     4201 atgtacagca gatactgcta acagagatgg aattgccaca tggttctcat caacacctct
     4261 atctgtcaaa ataacaacat ttgcaccatt tttatgcgcc tggtcaacag caacatataa
     4321 atgattgata gccttatcaa gcggtgttcc tttgtaataa gtaatcggca catcttttac
     4381 attgatattc tttacttttg cataacgaat ctttaataag tctgtatttg ttaaaatagg
     4441 gttgtgaatc tttaatacat ggcagttttc tgccttttct tccaacacat tcccctctcc
     4501 gccaacatag atggaagtag atgtaacgat ttcctcacga atcgcatcaa taggagggtt
     4561 tgttacctgt gcaaaaagct gtttaaagta atcaaataat ggatgatgtc tcttagaaag
     4621 tactgctaat ggagtatcaa cccccatcgc tccgattgct tcacttccgt ttaatgccat
     4681 cggtaataca gaatctttca cttcttcata agagtaacca aatgctttca tcaggcggtt
     4741 gctctcttca tagctgtatt cttctactgc aacattcgga atctttaagt cttttaagaa
     4801 tacaaggtta tcggataacc attcaccgta aggctgattc tttacataag aatcttttaa
     4861 gatttcatcg tcaatcagct caccttttac agtatctacg agaagcattt tacctgggtg
     4921 aagtctctct ttctttacga tatgtgttgt gtcaaagtct aacaccccaa cctcagaaga
     4981 aagaattaac tggtcatcat ctgtaatata gtaacgggaa ggtctaagac cattacggtc
     5041 aagtacggct cccatgatat ctccatctgt aaagaggata gatgcaggac catcccaagg
     5101 ctccatcatt gttgcgtagt actgatagaa gtctctcttc tctctgctca tgccctcgtt
     5161 attttcccaa ggttctggaa tcgtgatcat cattgccaga ggaagtggca ttccactcat
     5221 taagaggaat tctaatgtat tatctaatct tgcagagtca gaaccgtttg gatctacgac
     5281 tggtgtcagc ttaatcatct catccttcag ataatcagat tccatgtttt cctcacgggc
     5341 taacatctta tcggcattac cacgaatagt attaatctca ccattatgaa cgatgtaacg
     5401 ataaggatgt gctttctccc agcttggaac tgtgtttgtg gagaaacggg aatgaactaa
     5461 tgcgattgca gattcataat ccttatcctg aaggtcatta tagaataatc ttaactgtcc
     5521 aactaagaac atacctttat atacgattgt tctgctgctt aaagaaacaa cataagcaga
     5581 atcgttagac tgctcaaata ctcgtcttac aatataaagt cttctatcga agtcaagtcc
     5641 tcgtggaaca tcaaacggtc tctttacaaa tccctgcata atgcatggca tgcagtccgc
     5701 tgctttcttt ccgaggatgc ccggctgaac cggaacctct ctccagccta agaaatttaa
     5761 gccttctttt tcaacgataa tctcaaacat cttcttagca cggtttctct gtaactcatc
     5821 ctgtggcata aagaacatac caataccata gtcacgttcc ttgccaatag aaaagccgag
     5881 agtactacag gttttttcga agaacttatg ggatatctgc actaagatac ctactccgtc
     5941 acccgtttta ccctcggcgt ccttgccggc tctatgttca agattttcaa caattttcaa
     6001 ggcattcgac actgtctcat ggctcttaag acccttgatg tttactacag caccaatacc
     6061 acagttatca tgctccagac ttggatcata tagaccctgt cgcatattgt cctgatacat
     6121 ggtctcaccc tttcttgcat cactatgaaa tagtaaatat tcatcagttg taaattatat
     6181 ttttgtaatt agtaattatc aggaactctt aatcaaacct tatgattctc atgttctcat
     6241 gctcttgtaa tcttatgatt tcataatcct gaatgagtat ctatagtctg aataaaaatc
     6301 tataaatctc tgaataatta catatttaaa aagtaacaaa ttcattttca gaagtagttg
     6361 taatgacttc ctgcatttct ttttgttgtt atcatattac aacattttaa ataggttgta
     6421 aatataaaca ttaaggtgag ttgtctaata atttgattat ttatttttta atatattatt
     6481 ttctgattat tactcttgtt ttaggggata ttgtagttag tttatttggt ttttatttct
     6541 ttttagatta tattgttctt ataaaagtac aattttgttt gtgatttcac ctctttattc
     6601 atcgttattt tcagatttaa agacaattca tacaattata aatgtaattt tcaaatacaa
     6661 atcctgcatt ttattaacat tgtatacaaa ataacttaag aaaattaagt aagtaattgg
     6721 ttgaattcta caattttatg ccattgtcta aactagcata ctatttgtag tgaaaaagca
     6781 aaaaaagaat cggattcttt tttcgtaaac tgtcttttca aaaagaaaat ttccctaatc
     6841 tctcatacta atgtaagaaa ggagatttta attacacaca tggcaaatca gagcaataca
     6901 aaaagaaaaa attatacata ttaataataa tcaacaaaaa atgttgaaat tcgatacaga
     6961 aaggagaggc catttcgcaa aaaaatacgc atttattatt atagaaaaaa gaaaggagaa
     7021 atcacaatga ttattaacaa attttatgaa aaactctaca aggaacttat caacaaacta
     7081 gaatctgatt atattttaat ccctaacacg ccagaaaata gaaaagcaat taataatact
     7141 ctaacgacag tcccttgcac tgtaaaatct ttagaaaaag attcaaagat ttttaaagct
     7201 ttatctaaca aaaaagctaa agctaagcag ctttcaattg tacccaaaat ttctaaaact
     7261 ttatctctta ttataatagc cactttaatt tgtatgccat ttaataccat taacactctc
     7321 ccaacgccta cctaccaccc tactgtacaa gttagtattt tagatatttc tgatggatct
     7381 tctcaccaaa aagggaaaaa taaattatcc gaaatacaag aacaatacac aaacaaaaac
     7441 caagagcaac gtaatcctaa aaactacaaa aagaaagttg ctacaaatac atataataca
     7501 tataagaaac aaaataaatt ccatttaaca ttatccacaa aaaaagcaac tcaactttta
     7561 tcaactttta aaaagttttt tcttaaaaca aaaaatacat acgataattt atctgatgct
     7621 tatgatgtaa ttagtacttt atttgtattg atttccacag taaaagaatc tatacgctca
     7681 aaaaaattaa aatagtcctt ctatataatt ttattcaata ctattttcaa ttatacatta
     7741 aagccgttct tcacagaagt acggctttaa attttcttat gaaagccaag atagagtttt
     7801 aaatatcaaa acaatacttt cccttgcccc ttcctttcac atctttaatc aactcaaatt
     7861 cccgcattgt ttgaatcaga aatcccgcct tactgtcttt atatcccagt ttttgtttta
     7921 tttcttttcg cccaaagact tcttctcctg aaaagctttc gataatctcc tttatattta
     7981 atgcagtgac gctacctatg cttttattaa cttgtagttc tttcagcttt ttatataaca
     8041 tatatttatt ctctgcagtc aatacagacg tttcaaaaca gtgggtttta tcctgacttg
     8101 ttgtttcaaa cagtgttttt tcatcattca aacagtattt tttttcattt ccttgtgaat
     8161 ccagcgcatt aaacagtgat ttttctgtat tgaaacagtg attttgctct ctatattcca
     8221 ctgtttgttc ttttactaca gatgctaagt tctcactatt tatattattc atatactggt
     8281 atttattttc agcgttctgt atattctccg cccgttttcg catctccaat tcttcatttt
     8341 cccggaatat agttactcgt ataccatctc ccagttcctc aaacactggc tctctcaatc
     8401 catattctct gcattctttt atcattcttg ggattcctgt tccccacgct tctataagtc
     8461 ccatataacg aaatgcttca gcaatcgctg tatttctgca ctttgattta cctgatttag
     8521 ctgactgtat atccagtccc ccataaagca ttccgggaga tgttacttct atcctgtcat
     8581 catagacaca aacctgtata caagactcat ccaaataact tctatgaaca actgcattag
     8641 taatcaattc tcttattgtt cgaaccggga gttcatacgc ttcttttcta tgtaaccctt
     8701 ctatctttgc accaagattg atatgcttta atacaaattg ataagcattt tccagctgta
     8761 catataatgg tccatcaaat tctcttttat ctataaaaat atctctttct gttcctttaa
     8821 ataacgcaca ttgaattttg gcataccgta ttttattctt cgtcattagt ctaaacgcat
     8881 gggtgggttg aaggtctttt cctattcggc acaataaccc taagtcttct agtttctcga
     8941 ttgtcatttt atttataatt tcagtttttt ctgtattttg cttgggatct aatgacgttt
     9001 cctgtattgc tcttgttaca tatgttgtct gcacatcata tgccactttt tccattgcat
     9061 tacataatat cttcgcctct cgttccgagt actccatgtc tatttccggt aaagtatcat
     9121 aagaaatctt ttgaccttct aattctagtt cctttaactt tctatcatca gcaggacgac
     9181 ttgtatcatt tattcttata taagaacctt gttccttccc aaatgacttg agataataag
     9241 gacgcatacg tcctggaaaa acttctacaa caacaactgt tcttccttct aatgtctgta
     9301 ttgtaatttc cggatcaatt attggagtgc agctgtcaaa tatcatattt gaaatatcat
     9361 ctgctaatct aaatggattc ttctctccaa tcccaataac ttcattcgtc ttatcctcaa
     9421 ttccaataaa aattttaccc cccgtagaat tggaaaaagc aataacatct tttaataact
     9481 tctcatgtct tttcggtatc tctcttttaa attctatatt ttttccttct ccaaaatctt
     9541 ctttatatag cattcctgtc cctcttcaaa accattgtca gtacatctat cagtcattaa
     9601 tttgttatga tttattataa tacaattccc ttcttttttt caacatacaa gaagaagcca
     9661 tgcatcagca tagctgacac atagcttctc ttttgtattt cataaaatag ttttatcttt
     9721 tgtataacta atctgactga ccagttcagg ctttattatt tataaagctc aacgagtctc
     9781 tgcaggtgct cgtaacgagc cttagcaacc ttctcagatt cgttgaagag tctttcagct
     9841 ctttctggga atggcttaat cagacgagtg taacgggatt cgttatttaa gaattcctga
     9901 tatgatccgt cgccttcttt agatgttaat gtgaatggat tctttccttc agctttctta
     9961 gctgggtcga aggagaagag gttccagtaa ccagccttaa cggctttctt catctcatcc
    10021 tgacagtggt tcataccacc cttagcaata ccgtgaagtt cacatggagc gtatccgatg
    10081 atcagggatg gtccgttgta agcttctgct tctgcaagac atttaactgc ctggttaggg
    10141 ttagcaccaa gagcaatctg tgcaacgtat acatatccgt agctcatagc gatctctgca
    10201 aggctcttct tgctgatttc tttaccagct gctgcgaact gacaaacctc accgatgtta
    10261 gaagctttag aagcctgtcc acctgtgttg gagtacatct cagtatcgaa taccataacg
    10321 tttacgttct caccggaagc taatacatgg tctaatccac cgaaaccgat atcatatgcc
    10381 catccgtcac caccgaagat ccatacagat ttctttccga ggtaatcctt cttagcaagt
    10441 acttctttag atttctcaca tccggctgct gctgccttct ctaactctgc gataagagct
    10501 gttgttggct caacatttgc ctttgtgtca tcctttgtct caaggaactt atctgctgct
    10561 gccttgaact cagctgtagc cttgtctgat gcagcgatct ctttaacaag ctcgatagcc
    10621 tgatcacgga gatatctctg tccaacttcc atacctaaac catgctcagc attatcctcg
    10681 aagagtgagt tagaccaagc tggtcccttc ttagagttga tatttactgt gtatggtgat
    10741 gtagctgccg ggttacccca gatagaagaa catcctgttg cgttagagat gtacatctgc
    10801 tcaccgaaga gctgtgtaat aagtctagcg taagatgtct cagcacatcc tgcacatgag
    10861 cctgagaact caaggagtgg ctggttgaac tgtgatccct taggtgttgt atcaaccatt
    10921 ccggcatctg tcttcttaga aacgttagct actaagtaat caaatactgg ctgctctgct
    10981 gcctgagact cctgtggctg cattgagata gctgctgtag gacaaactgt gatacactca
    11041 ccacatccca tacagtcaag tggagatacg ctcattgtat acttgtaagc gcctgccttt
    11101 ggcttcatat cagcaacctt catgttgtca ggagctgcct ttacctcgtc atctgtaagt
    11161 aagaatggac gaattgtagc gtgagaacat acaaatgcac agttgttaca ctggatacac
    11221 ttctctggat cccactgtgg aactgtaacg gctgttcctc tcttctcgta tgcagaagca
    11281 cctgttacat actgtccgtc tgccttgtca gcgaatgctg aaactggaag gctgtctcca
    11341 tccatcttag cgattggatc aagaagctcg ttaacaagct taacaacctc tggacgtcct
    11401 gtgcgctctg ccttaggagc atctgcctct ggattcttcc aagactctgg aacctctacc
    11461 ttatgtacag cgtcaacacc ggcatcgata gccttgtagt tcatctctac gactgcgtca
    11521 cccttctttg agtatgactt cttagcagca gctttcatgt actcaatagc cttgtcgata
    11581 ggcattacat ctgcaagctt gaagaatgca gactggagaa ttgtgttagt tctcttgccc
    11641 attccgatct cgatagcctt gtcgatagcg ttgattgtgt aaagctgaat gttgttgtca
    11701 gcgatatatt tcttagcgtc agcgttgagg tgatgagcaa gctcttcatc tgaccactgg
    11761 cagttgatca tgaatactcc gcccggctta acatcctgaa ccatcttcat gccctggata
    11821 acgtatgcag ggttgtggca tgctacgaag tcagcctggt tgatgtagta tgggcttctg
    11881 attgggttgt caccaaatct caagtgagaa attgtaacac caccggtctt ctttgagtca
    11941 tactggaagt atgcctggat gtatttatct gtgtggtcac cgatgatctt tgtagagttc
    12001 ttgttagcac ctacagtacc gtctccacca agaccccaga acttacactc tactgtacca
    12061 ggagcagatg taataggagc tggtttaact tctgg
//
