LOCUS       c00053_gnlPro..        13883 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OMBAAOFB_53.
ACCESSION   c00053_gnlPro..
VERSION     c00053_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 18:23:49
            Original ID  :: gnl|Prokka|OMBAAOFB_53
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13883
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..414)
                     /locus_tag="ctg53_1"
                     /transl_table=11
                     /translation="MEHVDKKTNVMTTFVRFLNKKILQNPTNMIKYIGWFFNLMLQLIH
                     FTQEREILYMKMKREDVRNIAIIAHVDHGKTTLVDELLKQSGVFRANQEVQERVMDSND
                     IERERGITILSKNTAITYKGTKINVIDTPGHADF"
     protocluster    1..13883
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[8410:11852]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      8411..11852
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..13883
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13883
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             541..1176
                     /locus_tag="ctg53_2"
                     /transl_table=11
                     /translation="MADKMFENNQVSIVGEIVSDFRFSHEVYGEGFYMVDVAVNRLSNY
                     MDYIPLMISERLIDVNEDMVGQNIYVTGQFRSFNRHEEKKNRLVLSVFVRELEFLDEID
                     DEVKSNQIFLDGYVCKEPIYRKTPLGREIADLLIAVNRSYGKSDYIPCICWGRNARFAS
                     GFDVGGHVQIWGRIQSREYVKKLSETQTEKRVAYEVSVSKIDFLEELD"
     CDS             1571..2461
                     /locus_tag="ctg53_3"
                     /transl_table=11
                     /translation="MSIFKGAGVAIVTPMKNDEEVNYDRLEQMIEYQINQGTDCIIIAG
                     TTGESSTLTTEEHAEVIKAAVKFAKHRIPVVAGTGSNCTREAIHLSEEAEKAGVDGLLC
                     VTPYYNKATQGGLIRYYTEIANSVKLPIIMYNVPSRTGCNILPETAAKLYHDVENIVAI
                     KEATGNVAQAAKTMYLTDGKLDLYSGEDGIVVPLMSIGAIGVISVWSNVAPKDVHDMCM
                     AFFDGDTKKAMEIQLKAQPLIEALFSEVNPIPVKKALNLMGMEAGPLRSPLTEMTDANA
                     AKLAEAMKNYGIKLA"
     CDS             2565..3332
                     /locus_tag="ctg53_4"
                     /transl_table=11
                     /translation="MIRAIMSGCNGKMGQVITGICKEDADIEIVAGIDLYDGIKNDYPV
                     FPNISVCDVAADVIIDFSNAKAVDDLLVYSVDKQIPVVLCTTGLSEEQLKKVDEASKKV
                     AVLKSANMSLGINMLMELLKQAATILAPAGFDMEIVEKHHNQKLDAPSGTALALADSMN
                     EALGNAYTYTYDRSKERKKREKTEIGISAVRGGSIVGEHEVIFAGLDEVIEFKHTAYSR
                     SVFAKGAVQAAKFLSGKPAGFYDMGDVIKATIA"
     CDS             3429..5393
                     /locus_tag="ctg53_5"
                     /transl_table=11
                     /translation="MGQTDLRYLKSLSNQYPTIATAATEIINLQAILSLPKATEHFITD
                     VHGEYDQFLHVLKNGSGAIKRKIEDEFGNAISAAEKKAIATLIYYPEQKLEQVLKTEDN
                     LEDWYKVTLYRLIRICKNASSKYTRSKVRKALPKDFAYVIEELLTGRQEISDQEAYYNE
                     IIRSVIRTGRAAELVIAFCNLIRRLVVDHLHVVGDIFDRGPYPNLIMDTLMEHHSVDIQ
                     WGNHDVYWMGAASGSAACICNVIRISAKYGNLDLLEDGYGINLVPLARFAMKWYDKDSC
                     DCFKLDYREDEYDVHDAFLDEKMHKAITIMQFKLEGQLIKENPEFEMEKRLLLDKINIE
                     KGTVCVEETEYPLKDVSFPTIDWEDPYRLSEDEADVMERLVTAFVNCEKLQRHVRFLYT
                     QGSLYKVYNGNLLYHGCVPLNEDGTFTRVNVFGKEYAGKELYDVLEGYARKGYYAIDPK
                     EKKKGQDILWFIWENQNSPVFGKAKMTTFERYFIADKITHQEPKNPYYRLLEKEEVVNR
                     ILEEFGLEGAEAHIINGHIPVEAKKGESPVKCNGKLLIIDGGFSKAYQPKTGIAGYTLI
                     YNSYGLVLAAHEPFESVEKAVQDGSDIVSHTVLVQQVVRRKTVADTDIGKSLKESIHDL
                     EELLAAYRAGTIVEKNRAE"
     CDS             5426..6304
                     /locus_tag="ctg53_6"
                     /transl_table=11
                     /translation="LCTKLRCAKRNAEMRIDMLIGNHLSASKGYAAMGKAALALDANTF
                     AFFTRNPRGGKAKEIDEKDVEKFLNFAKEHEFGKIVAHAPYTMNLCAAKEDVRSFSKEM
                     LLDDLKRMEYTPYNYYNFHPGAHVGQGAEKGIALIAEALNEALKPEQTTTVLLETMAGK
                     GTEVGRTFEELREILDRVELNDKMGVCLDTCHVWDGGYDIVNDLDDVLNEFDRVIGLDR
                     LKAVHFNDSMNDCGSHKDRHAKIGEGKIGAEAMRRVALHPLLEGRPFILETPNDDEGYR
                     REIQMVREWTR"
     CDS             6889..8343
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_7"
                     /sec_met_domain="OKR_DC_1_C (E-value: 1.2e-12, bitscore:
                     37.9, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 6.4e-131,
                     bitscore: 426.2, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKEQQMRAPVYEALEKLKKRRVVPFDVPGHKRGRGNPELVELLG
                     EKCVSLDVNSMKPLDNLCHPVSVIKEAEELAAEAFRAEHAFFMVGGTTSSVQGMVLSCC
                     KAGDKIILPRNVHKSVINALVLCGAIPVYVNPEVDVKLGISLGMQVSEVERAILENPDA
                     VAVLVNNPTYYGICSDLRSIVRVAHEHHMLVLVDEAHGTHLYFGENLPVCAMDAGADMA
                     SVSMHKSGGSLTQSSLLLTGKGVNWEYVSQIINLTQTTSASYLLMSSLDISRRNLALRG
                     KESFAKVAQMAEYARDEINSIGGFYAYGKDMVNGGSVYDFDVTKLSVYTRDIGLAGIEV
                     YDLLRDEYDIQIELGDIANILAYISIGDRIQDIERLVGALADIKRLYSKDPAKMLNTEY
                     INPKVLVSPQVAFYSQKESMPVRQTAGRICGEFVMCYPPGIPILAPGEMITPEIIEYIV
                     YAKEKGCSMQGTEDPEVENLNVLAKK"
     CDS             8411..9274
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_8"
                     /sec_met_domain="Spermine_synth (E-value: 3.3e-52,
                     bitscore: 166.3, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 2.6e-13,
                     bitscore: 39.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWFSDYHTEKVKVSVKVQKQLFGLQTEFQRIDVFDSDEFGRFL
                     SSDGSIVFSEKDEFVYDEMIVHVPMAVHPHVKKVLVIGGGDGGVARELGYYDEIEQIDV
                     VEPDRVFVEVCKEFFPDNACGLSDERVTVYYEDGLKFLRMKHDEYDLIINDAIDPLGHT
                     AGLFTKEFYGNCFRALKDDGIMVYQHGSPFYDEDEESCRGMHRKASHSFPISRVYQAHI
                     PTCSSGYWLFGFASKKYHPLDDLDAKRWKERKIKTWYYTTNLHKGAFMLPRYVEDMLED
                     EEGRKK"
     CDS             9372..10631
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Epimerase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_9"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 6.5e-45, bitscore:
                     143.9, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 2.3e-35,
                     bitscore: 111.4, seeds: 81, tool: rule-based-clusters)"
                     /sec_met_domain="Epimerase (E-value: 9.8e-08, bitscore:
                     21.3, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRLLIIGCGGVAGVAIHKCCQNSKTFTEICIASRTKSKCDALKE
                     KLEKTTDTVITTAQVDADNTEELIALIKKYQPDAVLNVALPYQDLTIMDACLACKVDYI
                     DTANYEPEDTDDKEWRAIYEKRCKEEGFTAYFDYSWQWAYREKFKEAGITALLGSGFDP
                     GVTSVFTAYALKHYFDEIETIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWENGH
                     WVETKPMEIKREYNFPQVGEKDMYLLHHEEIESLAKNVPGVKRIRFFMTFGQSYLTHMK
                     CLENVGMLSTSPIEYEGREIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGKKDGKEK
                     TIYIYNVCDHQECYKEVGSQAISYTTGVPAMIGAALVVDKVWDKDGVFNIEEFDPDPFM
                     DMLNQYGLPWVVDENPQTVA"
     CDS             10719..11852
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_10"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 3.4e-14,
                     bitscore: 42.7, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKWQEIPTPCYVVDEKKLKQNLKILQNLEQETGCHVLLAQKAFSM
                     FSLYPLIGQYISGTTASGIFEARLGKEEMGKENHVFAPAYKEKDMEELVQICDHVIFNS
                     FAQYEKYQHYFLQQECTASAGIRVNPECSTQEGHEIYDPCGPGSRLGVVKSEFLDQLPE
                     GIEGLHFHTLCEQNADDLITTWHAFEEKFGSYLKQVKWLNLGGGHHITRADYQLDELKK
                     LICEIRRKYNVRVYLEPGEAIALNAGYLVTEVMDIVHNGMDILILDASAACHMPDVLEM
                     PYRPPLKDGYLPGEKPHTCRLSSMTCLAGDVIGDYSFAQKKQVGDRLVFEDMAIYSMVK
                     NNTFNGMPLPGIAVLREDGDVEMIKEFGYEDFKGRLS"
     CDS             11824..13047
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_11"
                     /sec_met_domain="PAD_porph (E-value: 6.7e-118, bitscore:
                     383.2, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISKADCPEMIKDTTPVQDGFFMPGEFEQHQGCIMIWPERPGSW
                     RNGAKEAETAFSAVIRAIAASETVYVAAGKKGIDHAKAFAESLKKEENLHPVVVFEMET
                     DDSWARDVAPTFLVNRTDGKISDLTAAGNGTAQTGDDVKNSQVRGVNWSFNAWGGEVDG
                     LYASYEKDNAFAWNFCRKFEFDCYDAEPFVLEGGSIHSDGEGTLLVTESCLLSAGRNPS
                     LTKEQIEEQLKCYLGVEKVLWLPRGIYQDETNEHVDNVCAFLRPGEVVLAWTNNQNDPQ
                     YAMSKASFEYLSSVRDAKARKLIIHKLPIPDIPVCITKEELEGYEFEEGEDVREVGERL
                     AASYVNFYFSNNAVVMPVFGGENEESDLRAQQIMAKLCPDRKIIPVYARDILTGGGNIH
                     CITQQIPL"
     CDS             13125..13883
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_12"
                     /sec_met_domain="CN_hydrolase (E-value: 8.6e-51, bitscore:
                     162.4, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRQIKAAAIQMKCDLEHKKNLQKAEQMIRKAAAEGANIILLPELF
                     EREYFCQQRRYDFYSYARTVEESEAVAMGVRLAKELGVVLPISFYERDVNNLYNSIACI
                     DGDGTILGVYRKTHIPDDHYYQEKFYFTPGDTGFKVFDTKYGCIGIGICWDQWFPETAR
                     AMALLGAELLFYPTAIGSEPILECDSMPHWRRCMQGHAAANLMPAIAANRIGREVVQPC
                     AENGGQESALEFYGSSFLTDETGEVIFSASR"
ORIGIN
        1 aaagtccgca tgaccaggag tatcgatgac attgatcttt gtacctttat aggtaatggc
       61 tgtgtttttt gaaaggatcg tgataccacg ttctctctcg atatcattgg agtccatgac
      121 acgttcctga acttcctgat tcgcgcggaa tacgccgctc tgctttagca gctcatcgac
      181 cagagttgtt ttaccgtggt caacgtgtgc aataatggca atattacgga catcttcacg
      241 tttcattttc atatacaaaa tctctctttc ctgtgtgaaa tgtattaact gtaacataag
      301 gttaaaaaac caacctatat attttatcat atttgtggga ttctgcaata tttttttatt
      361 caaaaacctg acaaaagttg tcattacatt cgttttctta tcgacatgtt ccatgaaaat
      421 ttgaatgtga tacatggtaa aaatattatg tcaggcaggt cataccgggc agaaacggtt
      481 cgaaaagaaa aaacgcacaa aaaaatatag gtgtatgacc gcaaggaagg gagaatattc
      541 atggcagata aaatgtttga aaacaaccag gtgtcgatcg tgggggagat tgtatcggat
      601 ttccggttca gccacgaagt gtacggagag ggattttata tggtcgacgt ggcagtcaac
      661 cgtctcagca attatatgga ttacatacca ttgatgattt cggaacgatt gatcgatgtc
      721 aatgaggaca tggtcggaca gaatatttat gtgacaggac agttccgctc attcaaccgg
      781 cacgaggaaa agaaaaaccg gcttgtactt tccgtttttg tgagagaact ggaattttta
      841 gacgagattg acgatgaggt aaagagcaac cagatctttt tagacggcta tgtatgtaag
      901 gagccaattt accggaaaac accgcttgga agagagatcg cagatcttct gatcgctgtg
      961 aaccgctctt atggaaaatc agattacatt ccgtgcatct gctggggacg aaatgcaaga
     1021 tttgcctccg gttttgatgt gggcggacat gtgcagatct ggggcaggat ccagagccgc
     1081 gaatatgtca aaaaattatc ggagacgcag acggaaaaaa gggttgcata cgaagtatcc
     1141 gtcagcaaaa ttgatttttt agaggaattg gattgacagt agaaatagat ggtgctatga
     1201 ttgctaaaag atacatattg cttgatagag gttgcgtgct ttaagagtag ttttccggat
     1261 gtggcagaag cagaggatgg aggataaaag gaaagaacgc cgaaggagta tatttgctgc
     1321 ggatatgttc ctgggcataa ggtaaagaac cttatgactg tcatcttaag ctgaaatggc
     1381 agaaagatgg ggcgctatcg gattcgacat atactgggta atacatatga ttagaattta
     1441 cgaaccggct catcagagtc ggttttttta attcataggg aaattacgtc ctatgaataa
     1501 ataaaatacc gtgtgcacaa agcagtgtat cctaacgtat cataatacag gaagcaggag
     1561 gattattaat atgtctattt ttaaaggagc cggtgtggca atcgtaacac caatgaaaaa
     1621 cgatgaggaa gtaaattatg acagattaga gcagatgatc gagtatcaga tcaatcaggg
     1681 aacggactgt atcattatcg caggtacaac aggtgagagc tctacgctga cgacagaaga
     1741 gcatgcagag gtgatcaaag ctgctgttaa atttgcaaaa caccgtattc cggtcgttgc
     1801 aggaaccggt tcaaactgta ccagagaggc aatccacctt tcggaagaag cggaaaaagc
     1861 cggcgtggat ggactgctct gcgtaactcc atattataac aaagcaacac agggaggtct
     1921 gatccgctac tacacagaga ttgcaaattc tgtaaaactt cctattatca tgtacaatgt
     1981 tccaagccgt accggatgca atatccttcc ggagacagct gcaaaactgt accatgatgt
     2041 tgaaaacatc gttgcgatca aagaggcaac cggaaatgtt gcacaggcag caaagaccat
     2101 gtatttaacg gatggaaagc ttgatctgta ttccggcgag gatggaatcg tagtaccgtt
     2161 aatgtcgatc ggagcaatcg gtgtgatctc cgtatggtca aacgtggcac cgaaggatgt
     2221 acatgatatg tgtatggcat tctttgacgg agatacgaaa aaagcaatgg agatccagct
     2281 aaaggcacag ccgctcattg aggcgctgtt ctccgaagtg aacccgatcc ctgttaagaa
     2341 agcgctgaat ctgatgggca tggaggcagg accgcttcgt tccccgctca cagagatgac
     2401 agatgccaat gctgcaaaac ttgcggaagc aatgaagaat tatgggatca agctggcgta
     2461 aggggcagtg gaacacggaa agccagattt gaaaaaacac cggaaatgtt ggtttgcagc
     2521 gtttccggtg ttgctttaaa taaagaaaag agaggaaaaa caacatgata agagcaatta
     2581 tgagtggatg taacggaaaa atgggacagg tgatcacagg aatctgcaag gaagatgcag
     2641 atattgagat cgtggcagga attgacctct acgatggcat caaaaacgat tacccggtat
     2701 ttccaaatat ttctgtctgt gatgtggcag cggatgtgat cattgatttt tccaacgcaa
     2761 aagcagtgga tgatcttttg gtatatagtg tggacaagca gatcccggta gtactctgca
     2821 cgacaggact ttctgaggag cagttaaaaa aggtggacga ggcatcgaaa aaagttgccg
     2881 tattaaaatc tgccaacatg tcgcttggaa tcaatatgtt aatggagctg ttaaaacagg
     2941 ctgcaaccat tttagcaccg gccggttttg atatggagat cgtcgaaaaa caccacaacc
     3001 agaaactgga tgcgccgagc ggtacggcac ttgcacttgc cgattccatg aatgaggcgc
     3061 ttggcaatgc atatacctat acttatgacc gcagcaaaga gcgcaaaaag agagaaaaaa
     3121 cagagatcgg tatctctgca gtgcgcggcg gcagcatcgt aggagaacat gaggtgatct
     3181 ttgcaggact tgacgaggtg atcgagttta agcatactgc atattccaga agtgtatttg
     3241 caaagggcgc tgtgcaggca gcaaaattcc tgtccggaaa accggcggga ttctatgata
     3301 tgggggatgt gatcaaggct acgatcgcgt agagcattga caataaatta acgttggttg
     3361 cccccgctca tttcctatga taagataaaa aagcagcaaa tgaacgtgaa aaagaaatga
     3421 ggaatactat ggggcagacc gacctgcgtt atttaaaaag tttatcaaat cagtatccga
     3481 ccattgccac agcggcgaca gagattatca atttacaggc gattcttagc ctgccaaaag
     3541 caacagaaca ttttatcaca gatgtgcacg gggagtacga ccagttttta catgtgctaa
     3601 aaaatggatc cggtgccatc aagcggaaaa tagaggatga atttggcaat gcaatcagcg
     3661 cggcggagaa aaaagcgatc gccacgctga tctattaccc ggaacagaag ttggaacagg
     3721 tgttaaagac ggaagataat ttggaggact ggtacaaagt cactttatac cgcctgatcc
     3781 gcatctgtaa aaatgcatct tccaagtata caaggtcaaa agtgcggaag gcacttccaa
     3841 aagactttgc ctatgtgatt gaggaacttt tgaccggcag acaggagata tccgatcagg
     3901 aggcatatta taatgaaatt atccggtcgg tcatccgcac cggaagggcg gcggagcttg
     3961 tgatcgcgtt ctgtaatctg atccgccggc ttgttgtgga tcatctgcat gtggtcgggg
     4021 atatttttga caggggacca tatccgaatc tgatcatgga cacactgatg gagcatcact
     4081 ctgtggacat ccagtggggc aatcacgatg tgtactggat gggagcggcg tcgggcagtg
     4141 cggcatgcat ctgtaatgtg atccgcattt ctgcaaaata tggaaacctt gatctgttag
     4201 aggacggtta cgggattaat ctggtgccgc tggcaagatt tgcgatgaag tggtatgata
     4261 aggattcctg tgactgtttt aagctggatt accgggaaga tgaatatgat gtgcacgacg
     4321 catttttaga tgaaaaaatg cataaggcga tcacgatcat gcagtttaaa ctggaaggtc
     4381 agctgatcaa agaaaacccg gaatttgaga tggagaaaag acttcttctc gataagatca
     4441 acatcgaaaa ggggaccgtg tgtgtggagg aaaccgagta tccgctcaag gatgtcagtt
     4501 ttccgacaat cgactgggaa gatccatatc gtctctcaga agatgaggcg gatgtgatgg
     4561 agcgtcttgt gactgcattt gtgaactgtg aaaaactgca gcgtcatgtg cgttttttgt
     4621 atacacaggg aagtctttac aaagtatata atggaaatct tctctatcat ggatgcgtgc
     4681 cgctgaatga ggatggcacg tttaccagag ttaacgtttt tggaaaagaa tatgccggaa
     4741 aagagcttta tgatgtgctt gagggctatg cgcgaaaagg ctattatgcg atcgacccga
     4801 aggagaagaa aaagggacag gacattttat ggtttatctg ggaaaaccag aattccccgg
     4861 tgtttggaaa ggcaaagatg acgacgtttg agcgttattt tattgcagat aaaataacgc
     4921 atcaggagcc gaaaaatcct tattacaggc tgcttgaaaa agaggaagtg gtcaaccgga
     4981 ttttagagga attcgggctt gaaggtgcgg aggcgcacat cattaacggt catattccgg
     5041 tggaggcaaa aaaaggagag tctccggtca aatgtaacgg aaagcttctg atcattgacg
     5101 gcggtttttc caaggcatat cagccaaaga cggggattgc cggatatacg ctgatttata
     5161 attcttatgg tctggtgctt gcggcgcatg aaccgtttga atcggtagaa aaagcggtgc
     5221 aggacggaag cgatatcgta tcccatacgg ttctggtgca gcaggtcgtg cggagaaaaa
     5281 cggttgccga tacagatatc ggaaaaagtt taaaagagtc gatccatgat cttgaggagc
     5341 tgctcgcggc atacagagcg ggcacgatcg tggagaagaa ccgggcagaa taaaagagca
     5401 ttcgcatata cagacaggag tattattgtg cacaaaatta aggtgcgcga agcgcaatgc
     5461 agaaatgagg attgatatgt taataggaaa tcatttatcc gcatccaaag gatatgcggc
     5521 gatgggaaag gcagcgctgg cgttagatgc caataccttt gcttttttta caagaaatcc
     5581 gcgtggcggt aaggcaaaag aaatcgatga aaaagatgtg gaaaagtttt taaattttgc
     5641 aaaggagcac gaatttggaa agattgttgc gcatgcgcca tatacgatga acctctgcgc
     5701 tgcaaaagag gatgtccgtt ctttttcaaa ggaaatgctg cttgatgact taaaacgcat
     5761 ggagtataca ccgtacaatt attataattt tcatccgggt gcccatgtgg gacaaggggc
     5821 ggaaaaaggg atcgcattga ttgcggaagc attaaatgaa gccttgaaac cggagcagac
     5881 aacgaccgtt ttacttgaga cgatggcggg aaaaggaact gaggttggaa gaacgtttga
     5941 ggagttaaga gaaatcttag accgtgtgga attaaacgat aaaatgggag tctgcctcga
     6001 tacctgccat gtgtgggatg gcggttatga cattgtaaac gaccttgacg atgtgttaaa
     6061 tgagtttgac cgtgtgatcg ggctcgaccg gctgaaggca gttcacttta atgacagcat
     6121 gaatgactgt ggctcccaca aggaccgtca tgcgaagatc ggtgagggaa agatcggtgc
     6181 agaggcgatg cggcgcgttg cattgcaccc gcttttagaa ggaagaccgt ttatcttaga
     6241 gacaccgaac gatgatgagg ggtacagacg ggagatacag atggtccggg agtggacgcg
     6301 gtaagatcgc tgcaaacctg aatagaaaat aaaaatatcc taaaatgaaa taaaaaagaa
     6361 aataccagaa ttttacagaa tacgttattg catttgccat gtgtgtatgc tatacttcaa
     6421 atcacatgaa tgcgaaaatt gttttcatgc aaatattcgt tacaatagat ggaaaaggat
     6481 ctattgtttg cccaccaaga gattggttaa gcccatacgg acaggcgggg caactgccga
     6541 ttgcggtgta agccgcgtta ttgattgagt tagaagctca aattttataa gttgattacg
     6601 gggatgatac ccggaatcca atatcacttg tgaaacggtc aataagagta gtatacgcaa
     6661 atatttgctg gcgatggtgc caacgcggac tctggagaaa atagtttttg cagaatgtag
     6721 atagattaca taaagtatga ctatgatgat aacgacgata gaagaacagg tgatggatgc
     6781 ctgttctttt tttgcgtttt tcagcctgac ggtaatgtca gggaaaaaca tttgatgaaa
     6841 agcagagcat gcagattttt atggaagcca agggggattt ttttagtcat ggacaaagag
     6901 cagcagatgc gtgcgccggt ttatgaggca ctggaaaagt taaaaaaacg aagagtggtg
     6961 ccgtttgatg tgccgggaca taagagagga aggggaaatc cggagctggt agagctgttg
     7021 ggagaaaaat gtgtgagtct ggatgtcaat tccatgaagc cccttgacaa tctctgtcat
     7081 ccggtttcgg tgatcaagga agcggaggaa cttgccgcgg aggcatttcg cgcggaacat
     7141 gcatttttta tggttggcgg aaccacttcc tcagttcagg gaatggtgct ttcctgctgt
     7201 aaggcagggg ataagatcat tttgccgcga aatgtgcaca agagtgtgat taatgcactg
     7261 gtgctctgtg gagcgattcc ggtttacgtc aatccggagg tcgatgtgaa acttggcatt
     7321 tcactgggaa tgcaggtgtc agaggtggaa cgtgcgattt tagagaaccc ggatgcagta
     7381 gcagttttag tcaacaatcc gacttactat ggaatctgtt cggatctgcg gtctatcgtg
     7441 agagtggcgc atgaacatca tatgctggtg ctggtggatg aggcacacgg aacgcatctg
     7501 tattttgggg aaaatcttcc ggtatgtgcc atggatgccg gggcggatat ggcgtctgtc
     7561 tccatgcaca agtcgggggg aagcctgacg cagagctctc ttcttctgac cggaaagggt
     7621 gtgaactggg aatatgtcag ccagatcatc aatctgacgc agacgacgag tgcatcttat
     7681 cttctgatgt cgagccttga tatttcgcgg agaaaccttg ccttgcgagg aaaggaatct
     7741 tttgcgaaag tggcacagat ggcggagtac gcgagggatg agatcaattc tatcggtgga
     7801 ttttatgcgt atggcaaaga tatggtaaac ggtggcagtg tctatgattt tgatgtgaca
     7861 aaactgtctg tatatacgag agatatcggg cttgcaggca ttgaggtcta tgatctgctg
     7921 cgggatgaat atgatattca gatcgagctt ggagatatcg caaatattct tgcctatatt
     7981 tccatcggtg accggataca ggatattgag cggcttgtgg gtgcacttgc agacatcaaa
     8041 cggctgtatt cgaaagatcc ggcaaaaatg ctgaatacgg aatatattaa tccgaaggtt
     8101 ttagtgtcgc cgcaggtggc attttattcg caaaaggaat ccatgccggt tcgtcagaca
     8161 gcgggaagga tctgcggtga atttgtcatg tgctatccgc ctggaattcc gattttagcg
     8221 ccgggtgaga tgatcacgcc ggagatcatt gagtacattg tttatgcaaa agaaaaggga
     8281 tgctctatgc agggaacgga ggatccggaa gttgaaaatc tgaatgtgct tgcaaagaaa
     8341 taacagcata gatcagcaaa aataaagatt cctgtgaaaa gaagattttt tcaaaagaag
     8401 ggagaagatc atggaacttt ggttttcgga ttatcacacg gaaaaagtca aggtgtcggt
     8461 caaggtgcag aaacagttat ttggtttaca gaccgagttt cagcggatcg atgtgtttga
     8521 ttcggatgag tttgggcgtt ttttaagttc cgacggtagt attgtttttt cggaaaaaga
     8581 tgagtttgtc tatgatgaga tgattgtgca tgttccgatg gcggtgcatc cgcatgtgaa
     8641 aaaggtgtta gtcatcggcg gcggtgacgg cggcgtggca cgagagcttg gctattacga
     8701 tgagatagag cagatcgatg tcgtggagcc ggatcgtgta tttgtcgagg tctgcaagga
     8761 attttttccg gacaatgcat gcgggttatc ggatgaacgc gtgacggtgt actatgagga
     8821 tggattgaaa tttttgcgga tgaaacatga cgagtatgat ctgatcatca acgatgcgat
     8881 tgatccgctt ggacatactg caggactgtt taccaaggaa ttttacggaa actgcttccg
     8941 tgccttaaaa gatgacggaa tcatggtata tcagcatgga agtccgtttt acgatgaaga
     9001 tgaggaatcc tgccgcggta tgcaccggaa agcgagtcat agctttccaa tcagccgcgt
     9061 gtatcaggca catataccaa cgtgttcttc tggatactgg ctgttcgggt ttgcgtcaaa
     9121 gaaatatcat ccgcttgatg atctggatgc aaagcgctgg aaagagcgga agataaaaac
     9181 ctggtattat accaccaatc tgcacaaggg agcatttatg ctgccgcgat atgtggagga
     9241 tatgttagag gacgaagaag gacgtaagaa ataataaaaa ttaaattaaa atttattttt
     9301 tcacacgcaa gatttgtgcc ccggcacaaa cttgagatgc gcaaaaagac agcgcaggaa
     9361 aggagattaa aatgggaaga ttattaatta tcggatgtgg cggagttgca ggagttgcga
     9421 ttcacaaatg ctgccagaac agcaaaactt ttacggagat ctgcattgcg agcagaacaa
     9481 aatcgaaatg tgatgcctta aaagaaaaac tggaaaaaac aacggacact gtcatcacaa
     9541 cagcacaggt ggatgcggac aatacggagg aactgatcgc cctgatcaaa aaatatcagc
     9601 cggatgctgt gttaaatgtt gctttgccat atcaggattt aacaattatg gatgcctgcc
     9661 ttgcatgcaa agtagactat atcgatactg caaattatga gccggaggat acggatgaca
     9721 aagaatggcg tgccatctat gaaaaacgct gtaaagaaga gggatttaca gcatattttg
     9781 actattcctg gcagtgggca taccgtgaaa aattcaaaga ggcaggaatt acggcattgc
     9841 ttggaagcgg gtttgatccg ggagtgacca gtgtatttac cgcttatgcc ctgaaacatt
     9901 atttcgatga gatcgagacg attgatatct tagactgtaa cggcggcgac cacggctatc
     9961 cgtttgcaac caattttaac ccggagatca acctgcgtga ggtttccgca aacggttctt
    10021 actgggagaa tggtcactgg gtagaaacaa aaccaatgga aattaaaaga gaatataatt
    10081 tcccacaggt tggcgagaaa gatatgtatc tgctgcatca tgaggaaatt gagtcccttg
    10141 caaaaaatgt acctggagta aagcggatcc gtttctttat gacctttgga cagagctatc
    10201 tgacacatat gaaatgttta gaaaatgtcg gaatgctctc aacatcaccg atcgagtatg
    10261 agggcaggga gatcgtacca atccagttct taaaagcact gcttccggat ccggcatctt
    10321 taggaccgcg cacggttgga aaaacaaata tcggctgtat ctttacggga aaaaaagacg
    10381 gaaaagaaaa gacgatttat atctataatg tctgtgacca tcaggaatgt tacaaagaag
    10441 tcggttccca ggcaatttct tatacaacag gtgttccggc tatgatcggt gcagcgttag
    10501 ttgtcgataa agtctgggac aaagacggtg tattcaatat tgaagagttt gatccggatc
    10561 cgtttatgga tatgttaaac cagtatggtc tgccatgggt tgtggacgaa aatccgcaga
    10621 cggtggcata aaataagaat atgtgtgaaa cgggttggat aaaattttaa atttgtcagc
    10681 ttttgcgcag cggatttttg cagaaatgga gaattatcat gaaatggcag gagattccta
    10741 ccccgtgtta tgtggtagat gaaaagaagc taaaacaaaa tttaaaaata ttgcagaatt
    10801 tggaacagga aaccggctgc catgtgcttc tggcacagaa ggcattttcc atgttttcac
    10861 tgtatccgct gatcgggcag tatatcagcg gaacgacggc gagcggaatc tttgaggcgc
    10921 gccttggaaa agaggagatg ggaaaggaaa atcatgtatt tgcaccggct tataaggaaa
    10981 aagatatgga agaactggtg cagatctgcg atcacgttat ttttaattcc tttgcgcagt
    11041 atgaaaagta tcagcactat tttttgcagc aggagtgcac tgcaagtgcc gggatccgcg
    11101 tgaacccgga gtgctccaca caggaagggc atgagatcta tgatccatgc ggaccgggat
    11161 caaggcttgg tgtggttaaa agtgaatttc tggatcaact gccggaggga atcgaaggat
    11221 tacattttca tacactctgc gagcagaatg cggatgatct gatcacgacc tggcatgcgt
    11281 ttgaggagaa gtttggcagt tatttaaaac aggtaaaatg gctgaactta ggcggcggtc
    11341 atcatattac aagagcagac tatcagttgg atgaactaaa gaagttaatc tgtgagatca
    11401 ggcgaaaata taatgtccgg gtctacctgg aaccgggtga ggcgatcgca ttaaatgcgg
    11461 gctatcttgt cacggaggtt atggatatcg tacacaatgg aatggatatc ctgattctgg
    11521 atgcatcggc ggcatgccac atgccggatg tgcttgaaat gccatataga ccgccgctaa
    11581 aagacggtta tctgccgggc gaaaagccgc atacctgccg gctttcttcc atgacctgcc
    11641 ttgccgggga tgtgatcggt gattacagct ttgcacagaa aaaacaggtg ggagaccgtc
    11701 tggtctttga ggatatggca atttattcca tggtcaaaaa caatacattt aacgggatgc
    11761 cgctgcccgg aattgcagtc ttacgggaag atggagatgt cgagatgata aaggagtttg
    11821 gttatgaaga tttcaaaggc agactgtcct gagatgataa aagatacaac accggtacag
    11881 gacggatttt tcatgccggg tgagtttgag cagcatcagg gatgtatcat gatctggccg
    11941 gagcgtcccg gttcctggag aaatggcgcg aaggaagcag aaacagcgtt ttcagctgtg
    12001 atccgtgcaa tcgccgcgag tgagacagtg tatgtcgctg ccggaaaaaa ggggattgac
    12061 catgcaaaag catttgcgga aagtctgaaa aaagaagaaa acttacatcc ggtggttgtc
    12121 tttgagatgg agaccgatga ttcctgggcg cgggatgttg cgccgacctt tctggtaaac
    12181 agaacggatg gaaagatttc agacctgaca gcagcaggaa atggtacggc gcagacaggt
    12241 gatgatgtaa aaaactcaca ggtgcgcggt gtaaactggt cttttaatgc ctggggcggt
    12301 gaagtggatg gactatatgc ttcttatgaa aaagacaatg cgtttgcatg gaatttctgc
    12361 agaaaattcg agtttgactg ttatgatgcc gaaccgtttg tgttagaggg cggttctatc
    12421 cacagcgacg gagagggaac attgcttgtc acggagtcct gtctgctcag tgcggggaga
    12481 aacccatcgc ttacaaagga gcagattgaa gaacagttaa agtgttacct tggcgttgag
    12541 aaagttttat ggctgccacg cgggatctat caggatgaga ccaacgagca tgtggacaat
    12601 gtctgtgcat ttctaagacc aggtgaagtt gtgcttgcat ggaccaataa ccagaatgat
    12661 ccgcagtatg cgatgtcgaa agcgagtttt gagtatctaa gttcggtgcg ggacgcaaag
    12721 gccagaaagc tgatcatcca caaacttcca attccggata ttccggtctg tatcaccaaa
    12781 gaagaactcg aaggatacga atttgaggaa ggtgaagatg tcagggaagt cggagaacgg
    12841 ctcgccgcct cctatgtaaa cttttatttt tccaacaatg cggtagtcat gcctgtattt
    12901 ggcggagaaa acgaagaaag cgacctgcgt gcacagcaga ttatggcaaa actctgcccg
    12961 gacagaaaaa tcataccggt gtacgcaaga gacatattga caggcggtgg aaacatccac
    13021 tgtattacac agcaaattcc cttataggga atttattgta caaccttcca tataggagaa
    13081 ttaattcact gtgcaaaaat aaaaagaaca gaaaggatac acgcatgaga cagataaaag
    13141 cagccgcaat tcagatgaaa tgcgacctgg agcacaagaa aaacttacaa aaggcagaac
    13201 aaatgatccg caaagctgcc gcggaaggcg caaatatcat tttactgccg gaactttttg
    13261 agcgggaata tttctgccag cagcgcagat atgattttta cagctatgca agaactgtgg
    13321 aggagagtga agctgtggca atgggagtac gtcttgcaaa agaattgggc gtggtgcttc
    13381 caatcagctt ttatgagcgt gatgtcaata acctctataa ttcgatcgca tgcattgatg
    13441 gagatggaac gatcctcggt gtgtatcgga aaacccacat cccggatgat cattattatc
    13501 aggaaaaatt ttattttaca ccgggagata ccggatttaa agtgtttgat acaaaatacg
    13561 gttgcatcgg tattggaatc tgctgggatc agtggttccc ggagacagcg cgcgcgatgg
    13621 cgctgctcgg tgcagaatta ttgttttacc cgacagcgat cggctcggaa ccgattttag
    13681 aatgtgacag tatgccgcac tggagacgct gcatgcaggg acatgcggct gcaaatctga
    13741 tgcctgccat tgccgcaaac cggatcggca gggaagtagt gcagccatgt gcggaaaatg
    13801 gcggacagga gtcggcactg gaattttatg gttcctcatt tctgacggat gaaacaggag
    13861 aggtgatctt tagcgcttcc aga
//
