LOCUS       c00051_gnlPro..        13372 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IMIBIEDD_51.
ACCESSION   c00051_gnlPro..
VERSION     c00051_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 23:48:51
            Original ID  :: gnl|Prokka|IMIBIEDD_51
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13372
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13372
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1359:3372]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1360..3372
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..13372
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13372
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             64..1032
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg51_1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 4.2e-26, bitscore:
                     82.8, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLGILGAGGIASTMAKTVAGMKDVEAYAVAARDLERARVFAQKY
                     EVKKAYGSYEEMLADDEVELVYIATPHSHHYLHAKMCLEAGKHVLCEKAFTVNTEQAQK
                     LFDLAKEKKLLITEAIWTRYMPSRKMINDIIESGVIGEVTAVTANLSYTVSHVERIRKP
                     ELAGGALLDVGVYPINFASMVLGDKVKDVKATAIFQNGVDILDSIAMVFEGDRMATLQC
                     GAREISDRMGSIFGTRGYMQVQNINNPEKITVFDTDHKEVASYVVPEQISGYEYEVESC
                     KKAIHEGKPECPEMPHAETIRIMKILDDIRKSWNYEIPCIE"
     CDS             1360..2121
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: FGGY_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg51_2"
                     /sec_met_domain="FGGY_C (E-value: 1.9e-07, bitscore: 21.7,
                     seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 3e-50, bitscore:
                     161.8, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LYYVGIDIGSTASKTVVTGDREMKFVLPTGWSSKETASEIASRLL
                     DQGIDVMSEGVRVAATGYGRVAVDYADFVITEITCHGRGGRELAGNECAIIDVGGQDTK
                     VILIDQGMIQDFLMNDKCSAGTGKFLEIMANRLGVTIAELFDLAEQGTVVPISSLCTVF
                     AESEVISMIGEGRSREDIAAGVVNSVAEKVAQLARRKQLPGTVLLTGGLSECPYFAEIL
                     SEKLGCVVEAMKDGRYAGAFGASLLAGEKKK"
     CDS             2221..3372
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg51_3"
                     /sec_met_domain="HGD-D (E-value: 4.6e-88, bitscore: 286.6,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIIKDLPEVFEEFAEQRKNSFLAIKKIKDQNIPVIGSYCTYFPQ
                     EIAMAMGAASVGLCSMSDETIPVAEQTLPKNLCPLIKASYGFAVTDKCPFFYFSDVVVG
                     ETTCDGKKKMYEFMSEFKDVFILELPHKQTEAALQYWKSEIIRFKEYLEKKFEVEITEE
                     KLREAVRISNEGRRALKDFYELMKQDPAPMKGENLYNVLYGTTFKFDRSKVPAEIDALT
                     VKLKEEYAAGKNEGKKHRILITGCPMGGATMKVVKAIEENGGVVVAFENCSGAKSVDRL
                     IDENDPDIYEAIARRYLNIGCSVMTPNPNRFELLNELIDEYQVEAVVEMTLQACHTYNV
                     EAGKVGRFVREEKKIPYLHVETDYSQSDVGQLNTRIAALIEML"
     CDS             3978..6518
                     /locus_tag="ctg51_4"
                     /transl_table=11
                     /translation="LTDMVLPDGEIGTEYQVQLEADTDVSWSLEEGSELPAGLTLSSGG
                     VISGTPQKEGSFSFTVQADNGIGVSSQELSLYVAQREQEPVIKQYELTSGTALINLGIH
                     AEGEQSRKRLFLYNAGTDSLHLSDFPQSRYFDFSYAPIFDTNTDEEMQPGSCAAVDIDD
                     KKNLPAGNYEETVTFETKEGASCKVTLKVIVGASSEKDYELSIETGTEEEFTESDFYDP
                     EFRVEKYVVVRNSGKKETRIRIDTSGLKNFEVDDQMAKWTEDYEEQDSKKLLKPGETLY
                     FYILPKQEYGIYDETFAFLADDGSRYPLHVTMNREKNPTEKKQLEITEKSAGGFPTMQW
                     GYKTLPEAKTYILKNVTDTDMKLSFNRSKECSVLLSGNAYLAPGESTELRLWPKLGLSV
                     GKYSFQVTVTAKTVAGEHLTTQNLYNSFIVGDRTYQGLADAVAPVTGITNGAEKTADAL
                     HLPKSLEVYGAEVNGEKTTFSASVKWDVENCAYDPKSKAAQSFLVNGSLELNEDENNEG
                     LDTAVQIMVQVDAYQTLNRPVIDTRWTRVITNYAMLYLRDLSNEADGYQFVTAKSQKDL
                     KKGNYTAQTKITNSELNQYPELKYIPEGTHSLYCRAYKENSSHVMEYGEWSDGVPVTVK
                     AKTPDAPVVQKVQVKKNDVRIVLNSKGEEPDGYDVVAARSKNGKEPSDYIKVKSGYSGS
                     SKELILRGVPAGTWYIGVHAYKYLNGSNTKVLSKWAEVRKVTVKTSLVTGKPAVKSAKV
                     SRQGTKRNVAVTFTVPKSCDGTDWVLAKKVSKSDNGSYTGVSSYAYTKKNQTKTTVVFK
                     NVKPGVYYLAGRAYVKGYAKSYTKWSKIKKIVVK"
     CDS             6758..7516
                     /locus_tag="ctg51_5"
                     /transl_table=11
                     /translation="MKQKKIAIIMAGILAAAAAMTGCAEQNKTETQVDYTQNSQEKSEQ
                     TKQKTAEKSQPDKKQVNKSTSIGKEDSNQTADKKTKISASSNNAGDVQNSENGTDSTAG
                     TDTDDSQTTGVDTSASEDNGSTGNGGTQSDQRADQAMIYDSEGNGRLISEADDGNWYDS
                     DGNYYGSWEDIEDAMVNENGVTDQDGNKYYWTAPHDASEEVTDPYDLYSWDPGTNSYIP
                     FQAAESDCSPVGRGNGWYYYDEDSGEYVPW"
     CDS             complement(7662..8555)
                     /locus_tag="ctg51_6"
                     /transl_table=11
                     /translation="MTKTEKAVTWAIEIANDPAHGYDQDNRWGPDYDCSSLVISAWQQA
                     GVPVKTKGATYTGNMKSVFLSCGFKDVTSKVNLSTGSGMKRGDVLLNIASHTVMHIGNG
                     QVVSASKNENNGYHGGKPGDQSGKEIKLQSYYNFPWDCVLRYTEDSSTTDPDPEPQPTA
                     GNAKIRKGQGYANKFANAGISITGKRDAATKKAGVKVLQTALNRDYGAGLDVDGIWGTN
                     TDNALGQHYVKNGETQYMVTAAEILLLLRAYDPNGVEIPGTFGSGLLSAVKAFQKAQGL
                     TVSGTCDRNTFLKLIS"
     CDS             complement(8743..9078)
                     /locus_tag="ctg51_7"
                     /transl_table=11
                     /translation="MKNNTIGKRIAEARINRNITQEHLEELSGLSVSTISRIETGKYMP
                     TIENLLKLSEILDVGLDYFLYDLLPHNKDIQSPAIQDAISIMNQMGERQTEYIVKILKI
                     YQASHQD"
     CDS             9227..9751
                     /locus_tag="ctg51_8"
                     /transl_table=11
                     /translation="MMFSLQTLQNQGITIRETVYKSLDKLLLWNKESENSKYLELALLH
                     MQAYANMGFALDEENKTIREILKKTGKTREDFFPKGYLLGKRIKLTKSQVRGMIGRWRP
                     SRDSPMTIGELVDDIIRKVKNHEEGRYIYQYHRTDVTTKGDIEVYELVINKDESYFYDV
                     KKFRFYTFMEE"
     CDS             9757..10464
                     /locus_tag="ctg51_9"
                     /transl_table=11
                     /translation="MIRIMILDDDEMYLKKEKDITEQYFAEKNVDCTVTIYQNVEWFLL
                     GLNEEKFDMYILDIRMPGENGIEAAREIRRLYPDPVIIFITNFVDYAIEAYEVNTYRYI
                     PKECLKEKLPQAYDALLPGIMEKEERYYIINKRNEVEKLAYSDIFYMKKEGKYVIFVHR
                     RGEVKIRASLSTVEKELNSKEFIISDRGYLANIQHVMKMKGRDLYMRDGNIITVGRERF
                     KGVREAILNYWGV"
     CDS             10468..11949
                     /locus_tag="ctg51_10"
                     /transl_table=11
                     /translation="MLKVLLYGLATFMETGIGVWIFSQTFSERRILEKKYYVLEWLLYS
                     LIFFGIYNFSVSLWQIDKKIEKYVIKVICIYIIGLIAGIIYDIFFVKKKEMVLRRILYI
                     GMIFWLTAQYWAGYQSLLMIILGSGIIVLYVFCYFDCTFKQAYVWNFFYAVNIGLIKEA
                     YVVYAGVFNHKQWDDFYSYPRGHTYQEVIFWILGCLFIFWIIKFILSVNSIKGILRTRL
                     KELFIIGLLEYVLLIVSIIYKFGTIKKENFVMTACLLAVSNIALIGVYVKFQKKTLEMR
                     NQILDMRCKLMEEEYEELRMSYDRYRCLVHDEKHLLLYIKECLENGELDSCITFLNHYK
                     RESIRYSGVAWTGIPEINFMLNIKVRKMEEKNIFFKVDSKIEKIPMKDIDFVVLLGNLL
                     DNAIEAAEKCEEGKGKITCIFRNINDMFIFKVKNTSIYKPYEKNTKFYTSKKEKDEHGW
                     GIESVKQIVRKYNGEIDFKYDKDFFEVEIIISDNT"
     CDS             11966..12094
                     /locus_tag="ctg51_11"
                     /transl_table=11
                     /translation="MNEMNDKIIGNVEKELDEIEIIDTESIEEKLSFIVYGTIVCC"
ORIGIN
        1 tgaagtagga atggaacata gaagtttata actttttata agttttcagt aacggacaat
       61 aaaatgaagt taggtattct gggggccgga ggcattgctt ctactatggc aaaaacagtg
      121 gcaggaatga aagatgtgga ggcatatgcg gttgctgccc gtgatctgga acgtgcccgg
      181 gtatttgcac agaaatatga agtaaaaaaa gcatatggat cctatgagga aatgctggca
      241 gatgatgagg ttgaactggt ttatatcgcc actcctcatt cacaccatta tctgcatgca
      301 aagatgtgtc tggaagcagg aaagcatgta ctttgtgaaa aggcatttac tgtaaataca
      361 gaacaggcac agaaattatt tgatcttgca aaagagaaaa agcttctgat cacagaagca
      421 atctggacaa gatatatgcc gtccagaaag atgatcaacg acattattga aagcggcgtg
      481 attggtgagg ttaccgcagt tacggcgaat ctcagctata cagtaagtca tgtggaacgt
      541 atccgtaaac cggagctggc aggaggtgct cttctggatg taggagtata tccaatcaat
      601 tttgcctcca tggtgcttgg tgataaggta aaggatgtaa aggctactgc aatctttcag
      661 aatggagtgg atattctgga cagtattgcc atggtgtttg agggagaccg catggcaact
      721 cttcagtgtg gagcaagaga aatctcagac agaatgggaa gtattttcgg aaccagagga
      781 tatatgcagg tgcagaatat caataatccg gaaaagatta cagtgtttga taccgaccat
      841 aaagaagtgg cttcttatgt tgtaccggaa cagatctcag gatatgaata tgaggtagaa
      901 tcctgcaaga aagcaattca tgagggaaaa ccggagtgtc cggaaatgcc tcatgcggaa
      961 acaataagga ttatgaaaat cctggacgac atccgtaaat cctggaatta tgagattccc
     1021 tgtatcgaat aaaaagtgtg gaataatctt ataaaaaaga ccagtaatgt tttgacatat
     1081 acccgaaacg ttactggttt ttcttttctg ctataatgga aatgtaacaa aaaaatttat
     1141 tgtgtcttga ttttaccaga taaatttata aagaggattt tatcattatc tgtcgtgtgt
     1201 cattgcttgt tcgtggggta aaaatcattt atagcttttt taaataaatc tcctgctttt
     1261 attgtatttt tgaatttttg attattaatg ggaaagggta taatagaagt tacagtaaac
     1321 agaatggata aaaataccaa aaaaagcagg tgagaaaagt tgtattatgt tggaattgat
     1381 attggttcga ctgcttcgaa gacagttgtg actggtgaca gggaaatgaa atttgtgctg
     1441 cctacagggt ggagcagtaa ggagacggct tcggagattg cttcaaggct tctggatcag
     1501 gggattgatg taatgagtga aggggttcgt gtagcagcta caggatatgg gcgtgtagct
     1561 gtggattatg cggattttgt gattacggag attacctgtc atggaagagg tggcagagaa
     1621 ctggcgggaa atgaatgtgc aattattgat gtaggtggtc aggatacgaa agtaatcttg
     1681 atagatcagg gaatgatcca ggattttctt atgaatgata aatgttctgc cggaaccggg
     1741 aagtttctgg agattatggc gaatcgactg ggagttacca ttgcggaact gtttgacctg
     1801 gcagaacagg gaactgtggt accgatcagt tcgttgtgta cggtatttgc ggaatctgag
     1861 gtaatcagca tgattggtga agggcgaagc agagaggata tagctgcggg agtggtaaat
     1921 tctgtagcgg agaaagttgc gcagcttgcc agaagaaagc agcttccggg gacagtgctc
     1981 cttacgggag gattgagtga atgtccgtat tttgcagaaa ttctttcgga aaaacttgga
     2041 tgtgttgttg aagctatgaa agacggaaga tatgcaggag cgtttggggc atcattgctt
     2101 gccggagaaa aaaagaaata aataatcaac tgtagaggat aataaggact gcaacagttg
     2161 gcgaatggta tgaaagaagt aaaaaataat ataaaaacga tagaaagatg aggtacaaag
     2221 atggaaataa ttaaagattt accagaagta tttgaggagt ttgcggagca gaggaagaat
     2281 tcatttcttg ctatcaagaa gattaaggat cagaatatcc cggtaattgg ttcttactgt
     2341 acatattttc cacaggagat tgcaatggcc atgggagctg cttctgtagg tttatgttcc
     2401 atgtctgatg aaacaatccc ggtagccgag cagacattgc cgaaaaatct ctgtccactg
     2461 atcaaggcca gttatgggtt tgcagtgaca gataaatgtc cattctttta tttttcagat
     2521 gttgtagttg gtgagactac ctgtgacgga aagaaaaaaa tgtatgaatt tatgtccgaa
     2581 tttaaggatg tatttattct ggagcttcct cataaacaga cagaggctgc acttcagtac
     2641 tggaagagtg agattatccg tttcaaagaa tatctggaga agaaatttga ggtggagatc
     2701 acagaggaga agcttcgtga ggcagtccgc atcagcaatg agggacgtcg tgctttgaaa
     2761 gatttctatg aactgatgaa acaggatccg gctccaatga agggtgagaa tctttataat
     2821 gtattgtatg gaactacctt taagtttgac cgttccaaag tcccggcaga gattgatgca
     2881 ctgacagtga agctgaaaga agaatatgca gcaggcaaaa acgaaggaaa gaaacatcgt
     2941 attctgatca ccggatgtcc aatgggcgga gctaccatga aagtagtaaa agcaattgaa
     3001 gaaaatggcg gtgtggtagt tgcttttgaa aactgctccg gtgcaaagag cgtagacaga
     3061 ctgattgatg aaaatgatcc ggatatttac gaagcaattg caagacgtta tctgaatatc
     3121 ggctgttctg ttatgactcc gaatccgaac cgttttgaac tgttaaatga actgatcgat
     3181 gagtatcagg tagaagctgt tgtggaaatg actcttcagg cctgtcatac ttataatgtg
     3241 gaagccggta aagttggcag atttgtaaga gaagagaaaa agattcctta tctgcatgtg
     3301 gagacagatt attctcagtc tgatgttgga cagctaaata cacgtattgc ggctctgata
     3361 gaaatgttat aactgtgaag gtattataag attatacgaa aaatgtcgaa ttgtatgtat
     3421 tttattatag caatcctttg aaataatgca tcttaatcca gcccatcaga gtgtgaaatc
     3481 ctgcgtcaga tatctttgcc gtgcgtcagc gcgcctgcag atatcttcct tgtctttcgc
     3541 gctctgctga actgtcttaa atgcattatt tacgaggatt gctatagaaa aaaatatgta
     3601 taagcaataa atgacaagcg actgatcaaa tttataaacc agaaactaaa aaatatggac
     3661 agaaaacaga agctctctct gtgggatgaa tttttccggc ggacagggct tttctgatat
     3721 tcatgaccat tagacaacat gtcattccgt aattacagaa acattcccgt ccagtggtat
     3781 attaatatta attaggtaaa ttgatacttt tatattttat tatctggagg agaagaatga
     3841 aaagtaatta caaaattttt acagcagttt ttttatcggc aattatgaca gcagcagctc
     3901 cgttaacagt atgcggggcg gaagtttttt cggcgggaga atctttcagt gatggaacag
     3961 ggagtattcc tgccatattg acagatatgg ttctgccgga tggagagatt ggaacagaat
     4021 atcaggtaca gcttgaagct gatacagatg tgagctggag tctggaggag ggaagcgagc
     4081 ttccggcggg acttacgttg tcttccgggg gagtgatcag cggaacaccg cagaaggaag
     4141 ggagtttcag ctttactgta caggcggaca atggtattgg agtttcttca caggaactga
     4201 gcctttatgt tgcacagcgt gagcaggaac ctgttataaa gcagtatgag ctgacatcag
     4261 gtactgcttt gatcaatctg ggaattcatg cagagggaga acagtcacgt aagcggttat
     4321 ttctttataa tgcaggaaca gattcgcttc atctctctga ttttccgcag agcagatatt
     4381 ttgatttttc ctacgcaccg attttcgata caaatacgga tgaagaaatg cagcccggaa
     4441 gttgtgcggc tgtggacatt gatgataaga agaatctgcc tgccggaaat tatgaagaga
     4501 cagtgacatt tgagacaaaa gagggtgctt cctgtaaggt tactctgaaa gtaattgtgg
     4561 gagcttcctc tgaaaaagat tatgagctga gtatagaaac aggtacagaa gaagaattta
     4621 cagaaagcga tttctatgac ccggaatttc gtgtggagaa gtatgtagtg gtcagaaatt
     4681 caggaaaaaa ggaaaccaga atacggatag atacttctgg tcttaagaat tttgaagtgg
     4741 atgaccagat ggcaaagtgg acagaagatt atgaggaaca ggattccaaa aagctgctga
     4801 aaccgggaga aacgctttat ttttatatat tgccgaagca ggaatacgga atttatgatg
     4861 aaacgtttgc atttctcgca gatgacggaa gcagatatcc tcttcatgtt acaatgaaca
     4921 gagagaagaa tccgacagaa aagaagcagc tggaaattac tgaaaagtct gccgggggtt
     4981 ttccgacaat gcagtggggc tataagacac ttccggaagc aaagacatat attctgaaaa
     5041 atgttactga tacagatatg aagctgtctt ttaaccgtag taaagaatgt agtgtgttat
     5101 tatctggaaa tgcttatctg gcacctgggg agagcacaga actgagactc tggcccaaac
     5161 tggggctttc ggtgggaaaa tatagttttc aggtgactgt gactgcgaaa acagtggcag
     5221 gagaacacct gacaacgcag aatctgtata attcttttat tgtaggagac cggacttatc
     5281 agggactggc agatgctgtt gcgcctgtga ccggaattac caatggtgca gaaaaaactg
     5341 ctgatgcttt gcatctgccg aagtcgctgg aagtctatgg cgccgaggtg aatggagaga
     5401 aaacaacatt ttctgcgtct gtgaagtggg atgtggagaa ttgtgcttat gatccgaaaa
     5461 gcaaggcagc tcaaagtttt ctggtcaacg gatctctgga actgaatgag gatgaaaata
     5521 atgaagggct ggacactgcc gtacagataa tggtacaggt ggatgcttat cagacattaa
     5581 acagaccagt tattgatacg cggtggacca gagtgatcac aaattatgca atgctttatc
     5641 tgagagatct ttccaatgaa gcggacggct atcagtttgt gacagcgaaa tctcagaagg
     5701 atctgaaaaa ggggaattat actgcgcaga caaaaattac aaattctgaa ctgaatcaat
     5761 atcctgagct gaagtatatt ccggagggaa cacatagtct ttattgcagg gcatacaaag
     5821 agaacagcag ccatgttatg gaatatgggg aatggtcaga cggggttccg gttacggtaa
     5881 aggcaaagac tccggacgca cctgtggttc agaaggtgca ggtgaagaaa aatgatgtca
     5941 gaatagtact taacagcaag ggtgaggaac cggacggtta cgatgttgtt gctgccagaa
     6001 gtaagaacgg aaaagaacca tcggattata taaaggtaaa gagtgggtat tccggaagca
     6061 gtaaagagct tatcttacgg ggcgtaccgg caggaacgtg gtatattggc gtacatgctt
     6121 ataaatatct gaatgggagc aataccaaag tgctcagtaa atgggcagag gtcaggaagg
     6181 taactgtaaa aacaagcctt gtaacaggaa aacctgctgt taaatcagct aaggtttcca
     6241 gacagggaac aaaaagaaac gtggcggtga cgtttactgt tccaaagtcc tgtgatggaa
     6301 cagactgggt actggcaaag aaagtttcca aatctgataa tggcagctat actggtgtaa
     6361 gcagttatgc ttacacaaag aaaaatcaga caaaaaccac ggtggtcttt aaaaatgtga
     6421 agcccggagt ctactacctt gcaggacgtg cctatgtaaa aggttatgca aaaagttata
     6481 cgaaatggtc gaaaataaag aaaatagttg tgaaataagt actgctgcca tttgtttcac
     6541 agagatttca cttttaagaa aaaagatatt ccccttttac caagcgttta taaggcaaaa
     6601 ttatggggta aagattttgg aaaaaaatgg ggtacatttc atgacagata agggacatat
     6661 gaggcatcga agcctgtgaa gtatgtcata atgaacagga aaagcacatt atgataaagg
     6721 catcgacatt tttaacaaat gtagaaagga taacaaaatg aagcagaaaa agattgcaat
     6781 tattatggca gggattttag cagcagcggc tgctatgact ggctgtgcgg aacagaataa
     6841 aacagagaca caggttgatt atacgcagaa ctcacaggag aaatccgaac agacaaaaca
     6901 aaaaacagca gaaaaatctc agccggataa aaaacaggta aataaaagta catccattgg
     6961 aaaagaagat tcaaatcaga ctgcggataa gaagacgaaa atatctgctt catccaataa
     7021 tgcaggcgac gtacagaatt cagagaatgg aacagacagt actgcgggaa ctgatacaga
     7081 cgattcccag accacagggg tggacacttc tgcatctgaa gataatggtt caacaggtaa
     7141 tggtggtact caatctgatc agagggcaga tcaggcaatg atatatgaca gtgagggaaa
     7201 tggaaggctg atttctgaag ctgatgatgg aaactggtat gacagtgacg gaaattacta
     7261 tggaagctgg gaagatattg aagatgctat ggtaaatgaa aatggtgtca cagatcagga
     7321 tggcaataaa tattactgga cagcacctca cgatgcatca gaagaggtca cagatccgta
     7381 tgacctgtat tcctgggatc cgggaaccaa ttcctatata ccgtttcagg ctgcggaatc
     7441 tgactgtagt cctgtaggca gaggaaacgg ctggtattat tatgatgaag acagcggcga
     7501 atatgttccg tggtagaata taaaaatgcg aaaagaagca gttttgagac cattttaatg
     7561 ggtttcaaaa ttgcttcttt ttgttatata catgaatagt gaaggggtat atccgacaga
     7621 atcaggggac agaattctgc cggatgttta tctggtaaag atcagctgat cagtttcagg
     7681 aaagtatttc tgtcacaggt tccggaaact gttaagccct gtgccttctg gaatgccttt
     7741 acagcagaga gaagtcctga gccaaaggta ccgggaatct ctacaccgtt tggatcataa
     7801 gcacgtaaaa gaaggagaat ctcagcggca gttaccatat actgtgtttc accatttttt
     7861 acataatgct gtccaagagc attgtctgtg tttgttcccc agataccgtc tacatccaga
     7921 ccggcaccat aatccctgtt cagagctgtc tgaagaactt taacgcctgc ttttttggta
     7981 gcagcgtctc tttttccggt aatagagatt cctgcattgg cgaatttatt ggcataaccc
     8041 tgacctttgc ggatttttgc atttcctgca gttggctgag gttcaggatc aggatcagta
     8101 gttgaagaat cttcagtata acggagaacg caatcccagg ggaaattgta ataactctga
     8161 agtttgatct cttttccgct ctgatctccg ggtttaccac catgatatcc attattttca
     8221 tttttgctgg cagataccac ctgaccatta ccaatgtgca ttactgtatg acttgcgatg
     8281 tttaataata catcgccacg tttcatgcca cttcctgtgc tgagattaac tttggaagtt
     8341 acatccttaa agccgcagga cagaaaaacg gatttcatat ttcctgtata agtggctcct
     8401 tttgttttta caggtacacc agcctgctgc catgcagaga ttaccagtga agaacaatcg
     8461 tagtccggtc cccatctgtt atcctgatca tatccgtgtg ccggatcgtt tgcgatttca
     8521 attgcccatg ttactgcttt ttctgttttt gtcatttttt tatcctcctg aaatttgatt
     8581 atttatttgc tcaccggtga tacatcttat aaagagtgag aaaagggaaa aatgtaaaca
     8641 tgaaacagaa aaaaataaaa agcatttcct gattgttgct tcgaggtcag aaaaatgctt
     8701 ttcgaggaca aaaacacgaa aattgtcgaa ttgtaattat atttaatcct gatgagaggc
     8761 ctggtatatt ttcagtattt ttacaatgta ttcagtctgg cgttcaccca tttgattcat
     8821 gattgaaatc gcatcctgaa tagccgggct ttgaatatct ttattatgag gaagcagatc
     8881 ataaagaaaa tagtcaagtc ccacatcaag aatttcagaa agcttaagga gattttcaat
     8941 agtaggcata tacttacctg tttcaatccg gctgatcgta cttacagata aaccacttaa
     9001 ttcttccagg tgttcctggg taatatttct gttgatccga gcttctgcaa ttctttttcc
     9061 gatagtattg tttttcataa ataaaaatcc tttcctttga taaagtttaa cagacggaat
     9121 taaatatgta taaggatata aatgacaagc gactaatcaa atttgatatg ttttatgaca
     9181 ggaggaatat aggaatatgg acgaatatac aaaggatttg tataccatga tgttttcttt
     9241 gcagactttg caaaatcagg gaattacaat cagagaaact gtatataaaa gtctggacaa
     9301 attactgtta tggaataaag aatctgaaaa cagtaaatat ctcgaattag cgttgcttca
     9361 tatgcaggct tatgctaata tgggatttgc tttagatgaa gaaaataaga caatacgtga
     9421 gatattaaaa aagacaggaa agaccagaga agactttttc ccgaaaggat atcttcttgg
     9481 aaagagaatt aaactgacca agtcacaggt tcgtggtatg attggaagat ggagaccttc
     9541 cagagacagt ccgatgacaa tcggagaact ggtggatgat atcatcagaa aggtaaaaaa
     9601 ccatgaggaa ggcagataca tttatcagta tcacagaact gatgtgacaa ccaaagggga
     9661 tatcgaggtt tatgagctgg tcatcaataa ggatgaaagt tatttttatg atgtgaagaa
     9721 attcagattt tatacattca tggaggaata attgctatga taagaataat gattctggat
     9781 gatgacgaaa tgtatctgaa aaaagaaaag gatatcacag aacagtattt tgcagagaaa
     9841 aacgtagatt gcacggtaac gatataccag aatgtggaat ggtttctgct gggattgaat
     9901 gaagaaaaat tcgatatgta tattctggat atccggatgc ctggagaaaa cggaatagag
     9961 gcagcgaggg aaattcgcag actttatccg gatccggtta ttatatttat tacaaatttt
    10021 gtggattatg caatagaagc atatgaggta aacacctatc gttatatccc caaagagtgt
    10081 ctgaaggaaa aacttccgca ggcttatgat gcgcttcttc ctggaattat ggagaaagaa
    10141 gagcggtact atatcataaa taaaagaaat gaagttgaaa aactggcata ttctgatatt
    10201 ttctatatga aaaaagaagg aaaatatgtg atttttgtgc acaggcgtgg ggaagtaaag
    10261 atcagagcaa gtctgtcaac agtagaaaaa gaactgaatt caaaagaatt tattatatct
    10321 gacagaggat atcttgcaaa catccaacat gtgatgaaga tgaaaggaag ggatctttat
    10381 atgcgggacg gtaatattat tacagttggc agagaaagat tcaaaggtgt cagagaagca
    10441 attctgaatt actggggggt atgaagaatg ctgaaagttt tattgtatgg actggcaacg
    10501 tttatggaga cagggatagg tgtctggata tttagccaga cgttttctga acgaagaata
    10561 ttagaaaaaa aatattatgt tctagaatgg ctgttgtatt ctttgatttt ttttggaatt
    10621 tataattttt ctgtttcatt atggcagatt gataaaaaaa tagaaaaata tgtcataaaa
    10681 gttatttgta tatacataat tggattaatt gcaggaatta tatatgatat tttttttgta
    10741 aagaaaaagg agatggtctt aagaagaata ttatatatcg gcatgatatt ttggttaact
    10801 gctcagtatt gggctggata tcaatcgttg ttaatgatta ttcttgggag tggaataatt
    10861 gtattatatg ttttttgcta ctttgattgc acatttaaac aggcatatgt ttggaatttt
    10921 ttctatgcag ttaatatagg attgataaaa gaggcttatg ttgtatatgc aggggtgttt
    10981 aaccataaac agtgggatga tttttattca tatccgagag gacatacata tcaggaagtt
    11041 atattttgga ttttaggctg tttattcata ttttggataa ttaaatttat tttgtcagta
    11101 aacagtataa aaggaatatt gcgtacacgt ctgaaggaac tttttattat tggattgtta
    11161 gagtatgttt tattaatagt tagcatcata tacaaatttg gtacgattaa aaaggaaaat
    11221 tttgtaatga ccgcatgttt attagcagtt agtaatatag cattgattgg tgtatatgtt
    11281 aagtttcaaa aaaagaccct agaaatgaga aatcagattt tagatatgag atgcaaatta
    11341 atggaagaag aatatgaaga attgagaatg tcatatgacc ggtatcggtg tttggtgcac
    11401 gatgaaaaac atttgctttt atatataaaa gaatgcctgg aaaatggaga actggattca
    11461 tgtatcactt ttttgaatca ttacaagaga gaaagcatta gatatagtgg agtagcgtgg
    11521 acaggaattc cagaaataaa ttttatgttg aatataaaag tgcgaaaaat ggaagaaaag
    11581 aatatttttt ttaaagtaga ttcaaaaata gaaaaaattc cgatgaaaga catagatttt
    11641 gttgtactcc taggaaatct tttggataat gcaatagaag ctgctgaaaa gtgtgaagag
    11701 ggaaaaggta aaattacgtg tatttttcga aatattaatg atatgtttat ttttaaagta
    11761 aagaatacaa gcatatataa accttatgaa aaaaacacta aattttatac aagtaaaaaa
    11821 gagaaagatg agcacggatg ggggattgaa agtgtcaaac aaattgtaag aaagtataat
    11881 ggtgaaatag attttaaata tgataaagat ttttttgaag tagaaataat aattagcgat
    11941 aatacataat gggagagtga cggttatgaa cgaaatgaat gataaaataa taggaaatgt
    12001 ggaaaaagaa ttagatgaaa tagagataat agatacggaa agtatagaag agaaattgtc
    12061 ttttattgta tatggaacta tagtgtgttg ctgaaattgg attatttatg cagaaaaaat
    12121 cgaactatgt ttcttaaaat attaatctta gatgtacatc ggcagaaaaa ttttggaaat
    12181 ctaaaaggaa gtacgccaaa agaacaatat gattattatg aaaaaaaata tcttaacaat
    12241 gcaacatatg taaaatcttt actgcaggaa tatcccgagt taaaacgtct gcttgaattg
    12301 aaaaataact ctatccagag agcagaatgt gaaatcagga aatctcttta tgcagaaaaa
    12361 gaacagatac aaaaaatatt ctgtgatgga agaaagtttt ccgggactgt gggaatttac
    12421 atgtcgaaag gcgatataca cagaggagga cgaagtgtgg cgaaggtaga attggataat
    12481 ggaacaattc tgtactataa gccacatagt cttgataaga atataaaata tcaggaactt
    12541 tataactatt tatgcagaaa aacaggaatt tcctgcagga cggtacaata tttatctcat
    12601 gattcctatg gatgggaaga aaaaattgag aatattccct gtaaaaacga aagtgaggtg
    12661 gagcattatt atttcagaat gggcatacat ctgtttttgg gatatgccct cggagcaaca
    12721 gatcttcatg gtgaaaatat tattgcacat ggagaatatc ctgtgattat cgatatggag
    12781 acatatccgg gatatttaaa acaacaatca gagaaagacg gaagtagtgt agaagaaaaa
    12841 ataaacaaaa gtacagagat aaaattggca aattcggtta tacatacagg aatgcttcct
    12901 gttctcacat ggggcagagg aaacagagga gttcttataa gtgcaatggg aacagaggaa
    12961 aagataaaaa caccgtttaa acttcctgtg gtaaaggatg ataaaacatc tgatatccac
    13021 atagaatatg aacctgtgga aatgcagata aaggaatgca ttgtaagact aaatgatcag
    13081 gttatcaatg cggcagatta tacggaatgc attatcagag gattttgcag agcgtacatg
    13141 gtggcaatgg cagataagaa agtggaggtg atgttgtccg gcttttttga cggacgttcc
    13201 agagttgtac tgcggcatac ccaacagtat gcaatgtatc ttatggcttc gtttcatccg
    13261 gattatatga agtcaagaga atgcaggaaa gctcttttga atgtgattca caaagagggg
    13321 gaatcttctt ttatgaaaga gattcatgat tatgaaattg acagccttct gg
//
