LOCUS       c00005_gnlPro..        13644 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CBCOOMDK_5.
ACCESSION   c00005_gnlPro..
VERSION     c00005_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 19:04:03
            Original ID  :: gnl|Prokka|CBCOOMDK_5
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 8042
            Orig. end    :: 21686
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13644
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[18042:21291]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13249
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..13644
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13644
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(143..1234)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043:Periplasmic binding protein-like domain (Score:
                     107.3; E-value: 3.4e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_9"
                     /sec_met_domain="Peripla_BP_3 (E-value: 9.8e-34, bitscore:
                     107.3, seeds: 83, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDNGKPKYFSLMEQLRSDIMSGAIRPGEKLPSENELSQKYSLSR
                     HTVRKALGILEQDGYVEAFHGRGTYCSENMRHIKNSKNIAVVTTYISDYIFPRLIQGMD
                     NVLSESGYSIILKNTANSRQKEARCLEELLKKDIDGLIIEPSKSEMICKHRNLYQNLDK
                     FEIPYVFIQGIYSEMRDKPHILMDDAQGGYLVTKYLLELGHKKIKGFFKADDMQGLERH
                     KGYVKALQESGIAYDPDDVVWFHTEDRKVKPALMAKEMVQSGQLPDGIVCYNDQIAVQV
                     MEELEKMGVRIPDDISITGYDNSLYAQRGSGITTIAHPQEKLGEMAAELILEKINGVPE
                     EESKVERLIYPELIIRGSCRKIL"
     CDS             complement(1426..2283)
                     /locus_tag="ctg5_10"
                     /transl_table=11
                     /translation="MIIAAIGLLIYCAGFYIKSYEQNLAARQEYAELSQMAGVKNREGA
                     GLLADGKKTDEDSSTKNSEKKRRKKQRRSSESKNKNCTDEIRESFGISWENLRKINSQT
                     VAWITVPGADISYPVVQAADDEYYLKHNFRGEEDLFGCIFLEHDIKKNFTDSHSILYGH
                     NIEGNMMFANLNRYEQPEFLKKCPEIEITTPKRKFLYKIFSVEQASSQSPAFEYGYKLS
                     SPAYRRQLSILKNNSMYDTGVEPDERERMVTLITCNSRLDKEIRMAVHGICHECYGIEK
                     AGPK"
     CDS             complement(2310..7019)
                     /locus_tag="ctg5_11"
                     /transl_table=11
                     /translation="MKHNFKLKERLGALLLAMLFILQAILGLVPVCVTQAAPLTVETWD
                     SDKVVDYGYRFNMKFQPGITTYESFGCDNLDREAFSDNGKSERDTECVRVGADYKAGSA
                     GMRYNNVGKDGNGNIVDVRLILVGVENAEPRYDLRTAESIVQNKGGATFAWKDNEAYPM
                     VGFSKNSIGVFIYSVGYAKVKFQFLKHGTEETLPISGHGTIRDIDAGQGVRIPSDSSLD
                     NAYVLKNNDYLTVDGNSVSSPLGSVEPDDPRGWLNLFYNTDNFTVEFCHQFRLDKWDKS
                     REDAIAKAGSQERWAEITRNKYLDPSGNSYCPNFKGQKYCKAYAYFDFTSYCFGDVEMK
                     KAPEKRVGEANCTWEQAAAASKEKPFGIRQGQEFQYMIRAEVTPNRLKSFVVQDILEDC
                     LTIEDASKVSIVNDAGQTVTDWFDVAVEGQKVTCRAKAESLQDEAFTDNQTYTFTLKVR
                     QRPESEINISKYLAEDGYSILVPNHASMSYERTNGSGDTMDTETVWVKGVIPPELEVKK
                     NTSQYEWKTGDIIDYEVLVSQTKQDVKAVNVVITDELPSCLQLLEGQYAVETSQGGENC
                     TLTGQGENGWKAECPSLKYGETITIRFKCQASADSNGQEWENIVTATADNLINPDTGEQ
                     ESRKDMAEVWPNSPQLEIDKTADKYEWQAGEQVAYRIVVNNVTAGTIAKDVTITDIGLP
                     QGLVLAGGTQSMEVLGVQQQVNYPVPDKKTGQAYEARPVDSQLNADENGFSFYCSYVPY
                     SQPVTIIFHCIAQEEANGHESVNAATVKAANTDERSDDAEVYVNSGEFWIEKSADHYEW
                     QVGEQVQYNVVVENKKAGTVARNVTVWDTGMPAGLALSSAEDVSVSGIPQNITQLTAGT
                     KDVLNQLNPEFYNETSEKPVNYEFLQEGSGWRLNISDLPANTPVMISFLCTVTEAANGM
                     ESINVANVQAQNAPVSQDDAEVYVNTAVLSIEKSFQNPYLAAGDGRAENEFRVGEQVNY
                     QVTVNNLQKGSIARNLVISDLSLPEGLALDGAEDAVTVSGVPAVIQNPVAGTDDAGNQL
                     NPENYKETVEKPVSCQVTRQGTGWIVTISDLPYQTPVTVNFRCTAQESVNGMEIVNTAQ
                     AYADNAQKVKDSSKIWVNSPVLKVEKTTDKPFYKYGDIITYRIVLTQEQTGCVARNVTL
                     QDVIDTQGVRLLKDSVILMDEKGNVADADVQINDDNTFLMSTGRTLVRDSRYSICDNDK
                     GGLFEQVMYNPLDCQEQKSMIVEYQAAVIDAALAGQKVHNTAVADSSEKIPATGEAETE
                     VHSPILEIVKESDKKEYASGEKGYYKLTVRQLREDVTDQNIVIEDKLETQGASIVKDSI
                     FVKKNGIELKDAKIEADDTGFVIQTGASLSDMDKIEVCYEMVFKTESTEPEKIVNTAKA
                     RGDISPEITAQQEAYVKAKAEPTATPTPSATPKPTETPKPTETPKPTEVPKPTEQPKAT
                     PTPSVPGTCPKMTPVPTKAPLASYNGGNNGGTTSGSGGSSYANSGGYSGGYGSYQGGSM
                     AGSSKTGDVRPFKMMAVLGLIGMGLLTGGVVIYRRTVSGKRNIKGMPRK"
     CDS             complement(7222..7683)
                     /locus_tag="ctg5_12"
                     /transl_table=11
                     /translation="MNRKEFLEILRSQLAGQMQEGKAAAHIRYYEDYIQSQVRGGRSEQ
                     EVLQELGDPHLIAKTLIDTDDGSTQEDYGEYSSYGSSYGNETELPHQQEKRWKKVIDLS
                     TWHGKAVVIAAAAVIIVLLILIIGVAIPFFIILAIILYFLSWLKKRNDQ"
     CDS             complement(7883..8761)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_13"
                     /sec_met_domain="CN_hydrolase (E-value: 2e-56, bitscore:
                     181.4, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNVTVAAVQMKCSKSVEKNIAHAEELVRQAAAKGAEIVLLPELF
                     ERPYFCQERRYEYYEYAQTAEENPAVRHFSRVAAELGIVIPVSFYEKEVNNTYNSVAVL
                     DADGKNLGIYRKTHIPDDHYYQEKFYFTPGDTGFKVFDTRFGTIGVGICWDQWFPETAR
                     CMALQGAELLFYPTAIGSEPILECDSMEHWRRCMQGHAASNLIPVIAANRIGEETVEPC
                     PENGMQKSALNFYGSSFITDNTGALCAELPGGEEGVLVSTFDLDALKADRLNWGLFRDR
                     RPEMYAKIVGK"
     CDS             complement(8863..9966)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_14"
                     /sec_met_domain="PAD_porph (E-value: 5e-128, bitscore:
                     417.0, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVTEKNRTKYRMPGEFEPHEGCVMIWPERPGSWNYGAREAQKAF
                     VKVAEAIGVSEKVYMLVSKAQMENAKNQLGNVSGVTLLECETDDAWARDVGATMVLDEK
                     GAVCGVDWQFNAWGGTFDGLYRNWEKDDRVAAFICRTLGCPCLDARPFVLEGGSIHSDG
                     EGTLIVTEACLLSQGRNPQMSREQIEEQLKYWLGVHKIIWLPCGIYQDETNEHVDNVCA
                     FVRPGEVVLAWTEDETDPQYAMSLADLKVLEQETDAKGRKFKIHKLPIPQKPVCLTQED
                     VDGFVFEEGEDEREAGERMAASYVNFYISNGGIILPQFGDENDKRAVEILQKCFPERRI
                     YPIDARAIIVGGGNIHCITQQIPGKNI"
     CDS             complement(10001..11089)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_15"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 5.7e-15,
                     bitscore: 45.7, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VIDEKKMRENLEILKKVQEDTGCKILLAQKAFSGFALYPMIGKYL
                     AGTTASGLFEARLGYEEMGKENHVFSPAYRTEDIEELDRICDHIIFNSTAQLKKFKEVC
                     TGASLGLRINPECSTQGDHAIYDPCAPGSRLGVTRENFDGECLKWIDGLHFHTLCEQNA
                     DDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYNVKLLEKCIQHMKETYDLDIYL
                     EPGEAVALNAGYLVTEVMDIVENEIRTLILDASAACHMPDVLEMPYRPPLKDSGEAGEK
                     AYTYRLSSCTCLAGDVIGDYSFDREIQIGDKLYFMDMAIYSMVKNNTFNGMPLPDIAVM
                     HEDGECEVIRHFGYEDFKSRLS"
     CDS             complement(11112..12302)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_16"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 5.6e-44, bitscore:
                     141.4, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 6.4e-26,
                     bitscore: 81.4, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIASRTKEKCDALKKKIESTTKTKIETAKVDADNAAEVAELIRAY
                     KPDAVLNVALPYQDLTIMDACLEAGADYIDTANYEAEDTEDPTWRAIYEKRCKEKGFTA
                     YFDYSWQWAYNEKFKEAGLTALLGTGFDPGVTSVFSAYALKHYFDEIHTIDILDCNGGD
                     HGYPFATNFNPEINLREVSANGSYWEDGHWVETEPMEFKSVYDFPEVGKKDMYLLHHEE
                     IESLAKNIPGVQRIRFFMTFGQSYLTHMKCLENVGMLSTAPVEFNGQEIVPIQFLKALL
                     PDPASLGPRTVGKTNIGCIFTGVKDGKEKSIYIYNVCDHQECYKEVESQAISYTTGVPA
                     MIGSMMVVTGQWKKPGVFNVEEFDPDPYMEALNKWGLPWKVCEDPELVKVWKANED"
     CDS             complement(12389..13249)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_17"
                     /sec_met_domain="Spermine_synth (E-value: 5.6e-54,
                     bitscore: 172.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 8.3e-16,
                     bitscore: 48.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFV
                     ALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDV
                     VESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKARYDLIINDSTDPLGHT
                     EGLFTKEFYGSCYKALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHI
                     PTCPSGYWLFGFASKKYHPLEDFRPERFDNLNIETWYYTTNLHRGAFMLPKYVEDLLEE
                     EENSL"
     CDS             complement(13252..13644)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_18"
                     /sec_met_domain="OKR_DC_1_C (E-value: 4.1e-15, bitscore:
                     46.5, seeds: 113, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="DICNILAYISIGDRLQDIERLVGALADIERLYKKDSTGMLSGEYI
                     APAVVASPQQAFYAEKESLPMEQTAGRISGEFVMCYPPGIPILAPGEMVTQEIVEYILY
                     ARDKGCSMQGMEDPKVEYLQVLKGGI"
ORIGIN
        1 ggaatgctca gcaacttttc ttaagcactc atctccgtaa agatcctgtg aacctgtaca
       61 aaaccagaac ttatagtttc ttcctgtttt catgataaaa ttcctcctag atttattttt
      121 attttttatt tatttcattt gtttacaata tttttctgca tgatccccgt atgatcagtt
      181 ccggataaat cagtctttca accttacttt cttcttcagg aactccgttg atcttctcaa
      241 gtataagctc tgctgccatt tctcccagct tttcctgcgg atgagctatc gttgtgattc
      301 cgcttcctcg ctgagcatac agtgaattgt cataaccggt aatggaaata tcatccggta
      361 tcctgactcc cattttctcc agttcttcca taacctgaac agcaatctga tcattgtaac
      421 agacgattcc atccggaagc tgtccgctct gtaccatttc ttttgccatc agtgcaggtt
      481 ttactttcct gtcctctgta tgaaaccaga caacatcatc aggatcatag gcaatccctg
      541 actcctgtaa ggccttcaca tatcccttgt ggcgctccag tccctgcata tcgtctgcct
      601 taaagaaacc cttgatcttt ttatgtccca gttccagcag atattttgtt acaagatagc
      661 ctccctgtgc atcatccata agaatatgag gtttatccct catttctgaa tagattccct
      721 gaataaacac atacggaatt tcaaatttat ccagattctg ataaagattt ctgtgtttac
      781 agatcatctc acttttgctt ggttcaatga tcagtccatc aatatctttc ttcagaagtt
      841 cctccagaca tctggcctct ttctgtctgc tgtttgctgt gtttttcagg ataatactgt
      901 aaccgctttc tgaaaggaca ttatccattc cctgtatcag tctcggaaaa atataatcag
      961 aaatatatgt ggtcactacc gcaatattct ttgaattctt tatgtggcgc atattctcag
     1021 agcaataagt acctcttccg tgaaatgcct ctacatatcc gtcctgctcc aggattccca
     1081 gtgctttacg aactgtatgt ctactcaggg aatatttctg cgaaagctcg ttttctgaag
     1141 gaagcttctc tcccggtcgg atagctcctg acataatatc acttctgagc tgttccatca
     1201 gtgagaaata tttcggcttt ccattatctg tcatgtcttc ttccctcctg tatttaggat
     1261 acaacttgta cgcacgtacg aacaagttgt tttttatgca taaattatac aaaatatcga
     1321 gagatttttc attagttttt tccaaaacac ctcgagggat agtgatatgt gaacagtaac
     1381 agttcatcct ttacgaaagt taccaatatc cgattgattt caacatcact tcggcccagc
     1441 tttttctata ccataacatt catggcaaat cccatgtacc gccatacgta tttctttatc
     1501 cagacgtgaa ttacaggtga tcagagtcac cattctctcc ctttcatcag gctctactcc
     1561 tgtgtcatac atggaattat ttttcaatat agataattgt ctcctgtatg caggactgga
     1621 taacttgtat ccatattcaa atgccgggct ttgggaagat gcctgttcca cagaaaaaat
     1681 tttgtacaga aactttcttt ttggtgttgt gatctcaatt tcaggacatt ttttcagaaa
     1741 ttcaggctgt tcataacggt tcagatttgc aaacatcata ttaccttcta tattatgccc
     1801 gtaaagaata ctgtgggaat ctgtaaaatt cttttttatg tcatgttcca gaaaaataca
     1861 tccaaacaga tcttcctctc ctctgaaatt atgtttcagg taatattcat catctgccgc
     1921 ctgaactaca ggataagaaa tatcggctcc cgggacagta atccaggcaa ctgtctgaga
     1981 gttgatcttt cttaaatttt cccaggaaat cccgaaggat tccctgattt catctgtaca
     2041 gtttttgttt tttgattcag aagatcttct ctgttttttc ctgcgttttt tttcactgtt
     2101 ttttgtactg ctgtcttcat cagttttttt gccatctgcc aataatccgg caccttctct
     2161 gttcttcacc cctgccattt gggaaagctc tgcatattcc tgccttgctg caagattctg
     2221 ttcataactt tttatataga agccggcaca atatataaga agcccgattg ctgctatgat
     2281 catacttact gcaaatgttc tgagtttttt catttccgcg gcataccctt tatatttctt
     2341 ttcccggaaa cagttcttct gtagatcacc acacctcctg tcagcagtcc cattccgata
     2401 agtccaagaa cagccatcat tttaaacggt ctgacatctc ctgttttaga acttcctgcc
     2461 atggaaccac cctgatagct tccgtatcca ccggaatatc cacccgaatt tgcgtaactg
     2521 ctgcctccgc ttccggaagt cgttcctcca ttatttccac cattgtaaga tgccaacggt
     2581 gctttcgtcg gtacaggagt cattttcggg caggttcccg gtacagatgg tgttggtgtg
     2641 gcttttggct gctctgtcgg tttcggtact tctgtaggtt ttggtgtctc tgtcggcttt
     2701 ggtgtttctg ttggtttcgg tgttgcagac ggtgttggtg tggcagtcgg ttctgctttt
     2761 gctttcacat atgcctcctg ctgtgcagta atttccggtg aaatatcacc tcttgctttc
     2821 gctgtgttta caattttttc aggctctgtg ctttctgttt taaataccat ttcatagcag
     2881 acttcaattt tatccatatc tgacaacgat gctcctgtct gaattacaaa tcctgtatca
     2941 tctgcctcta ttttggcatc tttcagttct ataccgtttt tcttcacaaa aatgctgtct
     3001 tttacaatgg aagccccttg ggtttccagt ttatcttcga taacaatatt ctgatctgtg
     3061 acatcctcac gcagttgtct tactgtcagt ttataatatc ctttttcacc ggacgcatac
     3121 tctttcttat ctgattcctt cacaatttcc agaatcggac tgtgtacctc tgtctctgct
     3181 tccccggttg caggtatctt ttcactgctg tctgcaactg cagtattgtg cactttctgt
     3241 cctgccaggg ctgcatcaat cactgctgcc tgatattcca cgatcatact tttctgttcc
     3301 tgacagtcca gaggattata cattacctgc tcaaaaagac cgcctttatc attatcgcag
     3361 atactatatc tactatccct gaccagtgtc ctgcctgttg acatcaggaa agtattatca
     3421 tcattgatct gtacatcagc atctgccaca tttcctttct catccatcag aatcaccgaa
     3481 tccttcagaa gacgtactcc ctgagtatcg atcacatcct gcaaagtaac attacgcgcc
     3541 acacatccgg tctgctcctg tgtcaggaca atgcggtatg taataatatc accatatttg
     3601 taaaatggtt tgtccgtcgt cttctctact ttaagaacag gcgagttcac ccagattttt
     3661 gaggagtcct ttactttctg tgcattatct gcatacgcct gtgctgtatt tacaatctcc
     3721 atcccattta cgctttcctg cgcagtacag cggaaattaa cagtcacagg tgtctgatac
     3781 ggaagatctg aaatcgtcac gatccatccg gttccctgac gtgtaacctg acagctgacc
     3841 ggtttttcca ctgtttcttt ataattttcc ggattcagct gatttcctgc atcatcagtt
     3901 cctgccaccg gattctgaat aacagccgga acaccgctta cagtaacagc atcttcagct
     3961 ccgtccagag ccagcccttc aggaagggaa agatcactga tcacaagatt tcttgcgata
     4021 gatcccttct gaagattatt aaccgtaacc tgataattca cctgttctcc tacccgaaat
     4081 tcattttccg cacgtccgtc cccggctgcc agatatggat tctgaaaact tttctcaata
     4141 gaaagaactg ctgtatttac atacacttct gcgtcatcct gtgaaacagg ggcattctgc
     4201 gcctgcacat tggcaacatt aatgctttcc attccatttg ccgcttccgt aactgtgcaa
     4261 aggaaagaaa tcataaccgg agtatttgcc ggaagatctg aaatgttcag tctccatccg
     4321 cttccctcct gaagaaattc ataattcacc ggtttctctg atgtctcatt ataaaattcc
     4381 ggattgagct ggttcaaaac atctttggtc cctgctgtca gctgcgtaat attctgtggg
     4441 attccgctta ccgatacatc ctctgccgat gaaagcgcaa gtcctgccgg cataccggta
     4501 tcccagacag ttacgttccg ggccactgta cctgcttttt tattctccac caccacattg
     4561 tactgtacct gttctccgac ctgccattca taatgatctg cagatttctc aatccagaat
     4621 tctcctgaat ttacatatac ttctgcatca tcagatctct catctgtatt agcagctttt
     4681 acagttgctg catttacgct ttcgtgtcca tttgcctctt cctgtgcgat acaatggaaa
     4741 ataatcgtta caggctgact gtatggtaca taagaacaat aaaaagaaaa tccgttctca
     4801 tctgcattca actgagaatc cacaggtctc gcttcatatg cctgtcctgt tttcttatcc
     4861 ggtacgggat agtttacctg ttgctgaact cccagtactt ccatgctctg tgtaccacct
     4921 gccagaacca gtccctgcgg cagaccaata tcagtaatag ttacatcttt tgcaattgtt
     4981 cctgccgtta cattattcac tacgatccgg taagctacct gctctcctgc ctgccattca
     5041 tatttgtctg ctgttttatc aatttcaagc tgtggactgt tcggccatac ttctgccata
     5101 tcctttctgg attcctgttc tcctgtgtca ggattgatca gattatccgc tgttgcagtc
     5161 acaatatttt cccattcctg tccattggaa tccgcagatg cctgacattt aaaacggatt
     5221 gtgatcgtct ccccatactt cagggacgga cactctgctt tccatccatt ttctccctgt
     5281 ccggtaagcg tacagttctc gcctccctga cttgtctcta cagcatactg cccttccaga
     5341 agctgcagac atgatggaag ctcgtctgta ataacaacat ttactgcttt tacatcctgt
     5401 tttgtctgag aaaccagaac ctcataatct atgatatctc ctgttttcca ttcatactga
     5461 gaagtatttt tctttacttc cagttccggt ggaatcacac cctttaccca cactgtttcc
     5521 gtatccattg tatctccgct tccgtttgta cgttcataac tcatggatgc atggtttggt
     5581 acaagaatac tgtatccatc ctctgcaagg tattttgaaa tattaatttc tgattccggt
     5641 ctctggcgta cttttaaagt aaatgtgtaa gtctgattat ctgtaaatgc ttcatcctga
     5701 aggctctctg ctttggccct gcaggtcact ttctgtcctt caacagcaac atcaaaccag
     5761 tctgtcactg tctgccctgc atcattcaca atactgactt ttgatgcatc ctctatagta
     5821 agacaatcct caagtatatc ctgtaccaca aaggatttca gtctattggg tgtcacctct
     5881 gcccggatca tatactgaaa ttcctgtccc tgacgaatgc caaaaggttt ttcttttgat
     5941 gcagcagctg cctgttccca tgtacagttt gcctctccca cacgtttctc aggtgctttt
     6001 ttcatctcaa catcgccgaa acaataggat gtaaaatcaa aatatgcata tgctttgcag
     6061 tatttctgtc ctttaaagtt cggacaataa ctgttgcctg atggatccag atatttattt
     6121 cttgtaatct ctgcccatct ttcctgagaa ccggcttttg caatggcatc ttcacgactt
     6181 ttatcccatt tatccagtct gaactgatga cagaattcta ccgtaaaatt atctgtatta
     6241 taaaaaagat tcagccatcc tctcggatca tccggctcaa cggaaccaag gggtgagctt
     6301 acagaattcc catctaccgt cagataatca ttgtttttca gaacatatgc attatccaga
     6361 ctgctgtctg acggaatacg gactccctgt cccgcatcaa tatcacgtat ggttccatgg
     6421 ccactgatcg gcagtgtttc ttctgttcca tgcttcagaa actgaaactt aacctttgcg
     6481 tatcctacag aataaataaa tacaccgata ctgtttttgg aaaagccaac cattggataa
     6541 gcttcattat ctttccatgc aaacgtagct ccgcctttat tctgaacaat cgattctgca
     6601 gtgcgcagat cataacgggg ttctgcattc tctactccca caagaatgag tctgacatca
     6661 acaatatttc catttccatc ttttcctaca ttgttataac gcatccctgc gcttccggct
     6721 ttatagtccg ctcctacacg aacgcactct gtgtcacgtt cactttttcc attgtctgaa
     6781 aaagcttccc tgtccagatt atcacaccca aaagattcat atgtggtaat tccgggctga
     6841 aacttcatgt taaagcgata accataatct accaccttgt cactgtccca tgtttctaca
     6901 gttaacggtg ccgcctgagt tacgcagaca ggcacaagcc ccagaattgc ctgcagaata
     6961 aaaagcattg caagcagcaa agctccaagg cgttctttca gtttgaaatt gtgtttcatt
     7021 ttccgtctcc tttccgaaca aaaaatataa aaatgaatgt gggatttttc cctgcacctg
     7081 gcaggattaa agaatagaaa taagttgaga ttgtatgatt ataaatattc aaggggaatt
     7141 aatatcgtga aacaagaacg tttacactta agattttaag attctgcgca gggtttcttt
     7201 tctgaaaccc tgcacagatt ttcattgatc atttcttttc ttcagccatg aaagaaaata
     7261 aagaataatt gcaagaataa taaaaaacgg aatcgcaact ccgattatca gtatcagtaa
     7321 aacaattata acagccgccg ctgcaataac aacagccttg ccatgccagg tagaaagatc
     7381 gattactttt ttccatcttt tctcctgctg atgaggaagc tctgtctcat tgccataact
     7441 acttccgtaa gaagaatact ctccgtaatc ttcctgtgta cttccatcat ctgtatcgat
     7501 cagagttttt gctatcagat gcgggtctcc cagttcctgc agtacttcct gctctgaacg
     7561 tccgccacgt acctgagact gtatataatc ttcataatac ctgatatgtg ctgctgcttt
     7621 gccctcctgc atctgcccgg caagctggct tctcaggatt tccaaaaatt cttttctgtt
     7681 catcttctac actccatttt gccagaaata catatcaaaa ctctactgct ctctccgtta
     7741 tcagtaacgt tcgtactctt attttaccat atataccgca ggtagcaact aatataatca
     7801 taaacttttt atgaaattct tataaacaca tatatcgttt tggaaataac actgcaaatc
     7861 cactcggatt ctcctgcttt cgtcattttc cgacaatttt tgcatacatc tccggtctgc
     7921 ggtctctgaa aagtccccag ttcagtctgt ctgcctttaa tgcatccagg tcaaaagtgc
     7981 ttacaagcac cccctcttcc cctccgggca gttctgcaca gagagcacct gtgttgtctg
     8041 tgataaaaga agagccgtaa aaattaagag cagatttctg cattccgttt tccggacatg
     8101 gctctactgt ttcctcaccg attctgttgg cagcgatcac agggatcagg ttggaggcag
     8161 cgtgtccctg catacatctt ctccagtgtt ccatgctgtc gcattccagg atgggttcac
     8221 ttccgatggc agtgggataa aagagaagct ctgctccctg cagtgccata catcttgccg
     8281 tttccgggaa ccactgatcc cagcagattc caactccaat ggttccaaat ctggtatcaa
     8341 aaaccttaaa gccggtatct cccggtgtga aatagaattt ttcctgataa taatggtcat
     8401 ccggaatatg tgttttccga taaatgccga gattctttcc atctgcatcc agaaccgcaa
     8461 cgctgttata agtattattg acctcttttt cataaaagct gaccggaatc acaatcccca
     8521 actctgccgc taccctgctg aaatgacgca ctgcagggtt ttcctctgca gtctgcgcat
     8581 attcataata ctcatatctg cgctcctggc agaaataggg ccgttcaaaa agctccggca
     8641 gaagaacaat ctcagctccc tttgctgctg cctgacgcac cagttcctct gcatgggcaa
     8701 tatttttctc cacactttta ctgcatttca tctgaactgc tgccactgtt acatttctca
     8761 tcctgtctgt tcctcctgct cctgtttaca taagtaagtt ttttcataac tttcaggtaa
     8821 taaccctcaa acacatgact ctcaaagttt tctgcatcaa ggtcagatat tttttccggg
     8881 aatctgctgg gtgatacagt gaatatttcc accgccaaca atgatggctc tggcatcaat
     8941 gggataaatc cttctttcag gaaaacactt ctgcagaatc tccactgccc ttttgtcatt
     9001 ttcatcccca aattgtggaa ggatgatccc tccattggaa atatagaaat tcacgtaact
     9061 ggcagccatc cgttctcctg cttcccgttc gtcttctccc tcttcaaaca caaagccatc
     9121 cacatcttcc tgggtaaggc agaccggttt ctgaggaatc ggaagcttat gaatcttaaa
     9181 ttttctgccc tttgcatctg tttcctgttc cagcaccttc agatcagcca aagacatggc
     9241 atactgcgga tctgtctcat cctctgtcca tgcaagcaca acctctccgg gccttacaaa
     9301 agcgcacacg ttatccacat gctcattggt ttcatcctga tagattccac atggaagcca
     9361 gataatcttg tggacaccga gccagtactt caactgttcc tctatctgtt ccctgctcat
     9421 ctgaggattg cgtccctgac tcagaagaca ggcctctgta acaatcagag tcccctctcc
     9481 gtcagaatgg atggaaccgc cctccagcac aaaaggtctg gcatccagac atggacaacc
     9541 gagagtcctg cagataaagg cagccaccct gtcatccttt tcccagttcc ggtaaagccc
     9601 gtcaaaggta cctccccagg cattaaactg ccagtcaact ccacagaccg cccctttctc
     9661 atccagaacc atggttgctc ccacatctct ggcccaggcg tcatctgtct cgcattccag
     9721 caaagtcaca ccggaaacat tcccaagctg attctttgca ttctccatct gagctttgga
     9781 aaccagcata tacacctttt cgctcactcc aatagcctct gcaactttca caaatgcttt
     9841 ctgtgcttcc cttgccccat aattccagga accgggacgt tccggccaga tcatcacaca
     9901 tccctcatga ggctcaaatt ctccgggcat acgatatttt gttctgttct tctctgtaac
     9961 ttccatgtct gtctcctttt ctttgatagc ccggcagata tcaggaaagc cggctcttaa
    10021 agtcttcgta tccgaaatgt ctgataacct cacactctcc gtcctcatgc ataaccgcaa
    10081 tatccggcag cggcataccg ttaaatgtat tattcttcac catagaataa atcgccatat
    10141 ccataaaata cagcttgtcc ccgatctgga tctctctgtc aaaggaataa tctccgatca
    10201 catctcctgc caggcaggtg caggaagata agcggtaggt atatgccttc tcccctgctt
    10261 ccccgctgtc cttaagaggc ggacgatagg gcatctccag cacatccggc atatggcagg
    10321 ctgcagaagc atccaaaatc agcgttctga tctcattttc cacaatgtcc ataacctctg
    10381 tcaccagata tccggcattc agggcaacag cctccccggg ctccagataa atatccagat
    10441 cataggtttc cttcatatgc tgaatacatt tttccaggag ctttacatta taatcctctc
    10501 tggtaatatg atgtccgcca cccatattca gccaggaaac ctcagacaga aattctccaa
    10561 acttctcctc taccgcctgc aatgttttct ccaggtcatc cgcattctgt tcgcagagcg
    10621 tatgaaaatg cagtccgtcg atccatttca gacattcccc gtcaaagttc tctctggtaa
    10681 cccccagcct tgaacccggc gcacagggat catagatcgc atgatccccc tgagtggagc
    10741 attccggatt aatacggagt cccagactgg ctccggtaca cacttcttta aatttcttca
    10801 gctgtgctgt ggaattaaag ataatatggt cacagatccg atccagttcc tctatatctt
    10861 ctgtacggta agcaggggaa aaaacatgat tctctttccc catctcttca tatccaagcc
    10921 ttgcctcaaa cagaccgctg gcagtggtac ctgccagata ttttccgatc atgggataca
    10981 gagcaaaacc ggaaaacgct ttctgcgcca gaaggatctt acacccggta tcctcctgga
    11041 cttttttcaa aatctccaga ttctcccgca tcttcttctc atcgatcaca tagcagggag
    11101 tttgcagttg attaatcttc attggctttc cagaccttta ccagttcagg atcttcgcag
    11161 actttccatg gaagtcccca tttgttcagt gcttccatat atggatccgg atcaaattct
    11221 tccacattaa atacacccgg cttcttccac tgtccggtca ctaccatcat ggaaccgatc
    11281 atagccggaa cacctgttgt ataggagatt gcctgggatt ccacctcttt atagcattcc
    11341 tgatgatcac atacattata aatataaata cttttctctt ttccgtcctt aacacctgtg
    11401 aaaatacagc cgatatttgt tttacccact gttctcggac ccaaagatgc aggatccggc
    11461 agaagagctt tcaaaaactg gatcggcacg atctcctgtc cattaaattc cacaggtgcg
    11521 gtggaaagca ttcctacatt ttccagacat ttcatatgtg tcagatagct ctgtccgaat
    11581 gtcataaaga aacggatcct ctgtactccc ggaatatttt ttgccagtga ttcaatctct
    11641 tcatgatgaa gaagatacat atccttcttt cctacctcag ggaaatcata gacagattta
    11701 aattccatag gctctgtttc tacccaatgt ccgtcttccc agtaggaacc atttgcggaa
    11761 acctctcgaa gattgatctc cgggttaaag tttgtggcaa aaggatatcc atgatcaccg
    11821 ccgttacagt ccagaatatc aatggtatgg atttcatcaa aataatgctt caaggcatag
    11881 gcactgaata cactggtaac acccggatca aaaccggttc ccagaagagc agtcagtcct
    11941 gcttccttaa atttctcatt ataagcccac tgccaggaat aatcgaaata tgcagtaaag
    12001 cctttttctt tacatctctt ttcgtagatt gcacgccatg tgggatcttc tgtatcctct
    12061 gcttcataat tggcagtatc aatataatcc gcaccggctt ccagacatgc atccatgatg
    12121 gtaagatcct gatatggaag tgccacattc aggacagcat ccggcttata ggctctgatc
    12181 aattctgcga cctctgctgc attatccgca tctacctttg ctgtctcaat ttttgtcttc
    12241 gttgtacttt caatcttctt tttgagtgca tcgcattttt cctttgtcct gcttgcgatc
    12301 ataatctctg taaaaacatc gctgttctga cagcatttgc gaattgccac tgaagctacc
    12361 ccaccacatc cgattaccaa taatctactc ataaactgtt ttcctcctct tccagtaaat
    12421 cttctacata ttttggaagc ataaatgctc ctctgtgaag gtttgttgta taataccatg
    12481 tttctatatt aagattatca aacctctccg gcctgaaatc ttccagtgga tgatatttct
    12541 ttgatgcaaa tccaaaaagc cagtatcccg agggacaggt agggatatgt gcctgataaa
    12601 ccctgctcac cggaaatgac cggaaaacct ttctgtgcat ctttctgcat tccacctcat
    12661 cctcatcata aaaaggactt ccatgctgat aaaccatgat tccgtcatct ctgagagcct
    12721 tataacagct tccgtagaat tcctttgtaa aaagtccctc tgtatgtccc agcggatctg
    12781 tggaatcatt gatgatcagg tcatatctgg cctttttatt ccgcaggaac cgaaggccgt
    12841 cttcataata aatgttgact ctctcatcct tcagtccctg ggcaatatcc ggaaacatct
    12901 ccgcacatac atccacaaac attttatcgg attccaccac atcaatgctc tcaatctgtg
    12961 gataatggat cagttctctg gcaactccac cgtcaccgcc accgataatc agaacatttt
    13021 ttacattggg atgtactgtc attggcacat gcgtgaccat ttcatcataa ataaattcat
    13081 ccttgtcaga aaatacgatc tcaccgtcca gagccacaaa tcttccaaat tcttcagact
    13141 caaacacatc gattctctga aattcacttt cccctgaaaa taactgtcgg ttaatccgga
    13201 cagaaagctt tacatttcct gtatggaact cggaatacca taattccatg atcagatacc
    13261 ccctttcaga acctgaagat attctacctt cggatcctcc attccctgca tggaacagcc
    13321 tttgtctctt gcataaagaa tgtattctac aatttcctgt gtcaccattt ccccaggagc
    13381 aagaatcggg attcccggag gataacacat aacaaattca ccgctgatcc tgcctgccgt
    13441 ctgttccatg ggcagagatt ctttctccgc ataaaatgcc tgctgtggag acgccaccac
    13501 tgcaggtgcg atatattccc cggaaagcat acctgtgctg tccttcttat acagacgttc
    13561 aatatcagcc aatgccccta ccagtctctc aatatcctga agcctgtctc caatggaaat
    13621 gtaagccaga atattacaga tatc
//
