LOCUS       c00010_gnlPro..        14514 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KODOIODJ_10.
ACCESSION   c00010_gnlPro..
VERSION     c00010_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 16:20:34
            Original ID  :: gnl|Prokka|KODOIODJ_10
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14514
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14514
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[230:4514](-)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(231..4514)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14514
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14514
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(231..4514)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg10_1"
                     /sec_met_domain="HGD-D (E-value: 8.2e-60, bitscore: 195.3,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 1.2e-37, bitscore:
                     121.9, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENNTLHKLGIDIGSTTVKVAILDQEDHLLFSDYERHFANIQETL
                     SSLLQKAYDALGDFAVAPMITGSGGLTLAKHLGVPFVQEVIAVSTALQHYAPQTDVAIE
                     LGGEDAKIIYFEGGNVEQRMNGICAGGTGSFIDQMASLIQTDATGLNEYAKNYKAIYPI
                     AARCGVFAKTDIQPLINEGATREDLSASIFQAVVNQTISGLACGKPIRGHVAFLGGPLH
                     FLSELKAAFIRTLNLDDEHAITPENSHLFAAIGSALNYKPGETTTLVSLRDRLANGIKM
                     EFEVARMDPLFASQEEYDAFRARHDGHNVRSADFSTYEGNCYLGIDAGSTTTKIALVGE
                     DGSLLYSFYSNNNGSPLATAIRSIKEIYTLLPPKAKIVHSCSTGYGEALLKAALMLDDG
                     EVETVAHFYAAAFFDPEVDCILDIGGQDMKCIKIKNQTVDSVQLNEACSSGCGSFIETF
                     AKSLNYSVQDFAKEALFAKNPIDLGTRCTVFMNSKVKQAQKEGASVADISAGLAYSVIK
                     NALFKVIKLSDASQLGKNIVVQGGTFYNDAVLRSFEKIAGVECVRPDIAGIMGAFGAAL
                     IARERHEAGYQTSMLSIEQINALTFDTKLARCQGCTNHCLLTINRFSGNRQYITGNRCE
                     RGLGKEKNKDNIPNLYEYKNKRLFDYTPLSAEEAARGTVGIPRVLNMYENYPFWATFFK
                     KLGFSVVLSPQSTRKIYELGIDSIPSESECYPAKLAHGHVTWLIHQNVDFIFYPCIPYE
                     RNEFPDSNNHYNCPIVTSYAENIKNNVDEITSGQVKFLNPFMSFASEETLSSQLIKTFG
                     QSEFGIPESEIRDAVAEGWKELAVCRMEMQKKGEEVLQYLKETGRRGIVLAGRPYHVDP
                     EINHGIPELITSYGIAVLTEDSISHLQPVERPLIVMDQWMYHSRLYAAANYVKTRDDLD
                     LIQLNSFGCGLDAVTTDAVNDILTKSGKIYTCLKIDEVNNLGAARIRIRSLISAIRVRE
                     KKQTKRTIVPANYNRVVFTEEMRKNYTILCPQMSPIHFELLEPAFQTAGYNLVVPDVDS
                     RTCVDVGLKYVNNDACYPSLIVVGQLMAAVMSGGYDMSRTAVLISQTGGGCRASNYIGF
                     IRRALEKAGYPDVPVISINLSGLEKNPGFKLTLPLIQHGLYALEFGDIFMRCVYATRPY
                     EAVAGSTDELHEKWKKEVIAFITQKKMLSHGKFKKMCREIIRDFDNLPRKDIKKPRVGV
                     VGEILVKFHPAANNHLVELLESEGAEAVVPDLTDFLLYCFYNTGFKADNLGMSQKSKKI
                     GRLGINFFEWLRSAARDEFTKSRHFTAPAHIDDLARYARDIVSEGNQTGEGWFLTGEML
                     ELIHTGTPNIVCTQPFACLPNHVVGKGVIKELRHRYPGSNIVAIDYDPGASEVNQLNRI
                     KLMLSTANKNLAKQNAPEQKDQAAG"
     CDS             4776..5633
                     /locus_tag="ctg10_2"
                     /transl_table=11
                     /translation="MNWLNKLERKFGNWAIPNLIVWLIGAYTIGFVLYQVNPSIIGLLM
                     LSPYHILHGQIWRLITWVFMPTDTNLVYLLIMALFYYQLGTTLERTWGTFRFNVYIFGG
                     MLFTVIGAFLLYGIMYLLNGGVTTEMLLIGTSFSTSYINMSIFLAFACMYPDMQVLLMF
                     IIPIKMKWMAAVYGVLIALSFFETGWAGRMAIFMSLLNFIIFFFSTRNLKRYTPHEVHR
                     RQKFKADMRRPQGYAGGAKHKCAVCGRTELDDPTLEFRFCSKCEGNYEYCQDHLFTHQH
                     IRMS"
     CDS             complement(5709..6809)
                     /locus_tag="ctg10_3"
                     /transl_table=11
                     /translation="MAGSTLGTLFKITTWGESHGKGVGVVIDGCPAGLSLCEADIQKFL
                     DRRKPGQSRYATPRKEDDAVEILSGVFEGKTTGTPISLVVFNRNQQSRDYSEIASYYRP
                     GHADYTFDQKYGFRDYRGGGRSSGRETIGRVAAGAVAVKILNELGITFITYTKSIGPIA
                     VSSGRFDFSEVTKNPLYMPDAEAAENAENYLDACMAELNSSGGIVECIIKGMPAGIGDP
                     VFEKLNANLAKAVMSIGAVKGFEIGDGFDVAKATGKNNNDAFVLGEDGRIAKATNHAGG
                     ILGGMSDGSDIILRAAIKPTPSIAATQRTVNQSGEEISVNIKGRHDPIIVPRAVVVVES
                     MAAITIVDALFSNMSARMDALKDFYS"
     CDS             6934..8259
                     /locus_tag="ctg10_4"
                     /transl_table=11
                     /translation="MIEKYLVKKITEPVDWKVTVPGSKSMTNRALLMAVLSAGTVRVEG
                     VLFSDDSRHFLACLVALGFTVEIEEEKKCVTVTGCGGRIPRGEAVIDVGSAGTAARFLA
                     AMLGFSDGCYEIRCSAQMKRRPMAELFDLLSGVGAKITFLEEEGHLPVRITGCRYARAD
                     KTAGETPRELSLDITKSTQFLSALLLIAPMVPEGMKIHITSEKTDGSYIRITRKMMQEF
                     GVSVAFDGRDYEVPCRSSYRKETYMVEPDMSAACYFYAAAAVTGGRALVRHVHMDNIQG
                     DLRFLEVLEHMGCTADDTPEGVLVTGPADGALRGITVNMNDFSDQALTLAAIAPFADAP
                     VRIEGIGHIRGQECDRIHAIQTNLTALGIRCEEEETAATIYPGSPHGGSVETYDDHRVA
                     MAFSLVGLRTDGIVIENPACCRKTFEDYFTVLSELTGKKTEA"
     CDS             8306..9457
                     /locus_tag="ctg10_5"
                     /transl_table=11
                     /translation="MYELLKQEGRAKRGVFHTVHGDIQTPVFMNVGTVAAIKGAVSTED
                     LEQIKCQVELSNTYHLHVRTGDKLIREVGGLHKFMSWNRPILTDSGGFQVFSLAGLRKI
                     KEEGVYFHSHIDGAKIFMGPEESMQIQSNLGSTIAMAFDECPPALAERKYVEDSVARTT
                     RWLERCKNEMQRLNGLEDTVNRHQMLFGINQGAIYTDIRIDHAKRISELDLDGYAVGGL
                     AVGETHEEMYHVLDETVPYLPVNKPTYLMGVGTPANILEGVERGIDFFDCVYPSRNGRH
                     GHVYTNQGKINLFNQKYEKDMRPIEEGCGCPTCRRYSRAYIRHLLKAKEMLGMRLCVLH
                     NLYFYNTMMEEIRDALDAGNFASYKEEKLYGMGQINREKEMAK"
     CDS             9556..9873
                     /locus_tag="ctg10_6"
                     /transl_table=11
                     /translation="MFSILATESASSAGWISMVVWLVILFAFMYFFMVRPQKKEQQKKN
                     SMLAELAVGDTILTTSGFYGTVIDIADDTVIVEFGSNKNCRIPMQKAAISAVEKPEDVT
                     E"
     CDS             9962..12457
                     /locus_tag="ctg10_7"
                     /transl_table=11
                     /translation="MKRKKNTFVSRAAVGCVTTAIFLLLCIIKGIYPFGIATLDTVDFQ
                     SQWIPAYYHVWDVLHGDGSAFFDWRVGGGNNFAGVSAQFSLFSPFNLFFLFVKRSWIEK
                     SMIVFLLIKLLAMGYGMRWFLKEQILKEERYGIYILAGSVGYAVNGYTLLYYGMGWLDV
                     AAILPLLCYFFCRMAEREGDWRLGKNTLGYIVCLTLVFIINIPQAYMMCFFLIVFAGGY
                     FFLNRQDQPLKKNSILKFGLTSLLSLGIAAVIFLPAARAMLGSYRLSGEEYRGISGYFL
                     LLRQDGMDAVWKWVILGSVAVPLLFFVISGRRKWEHIWQWYLVTAMVLPVLFEAVNLIW
                     HRGTYVCFPMRYGYMLVFAVIYMAAARVPDFVGESRTRRNILYAFLGIWCVQMVALGIA
                     LIQPEPHMDETDFVGDATEIGQPLAGKTDIFHKAKLADGAIDNNYPLIAESTSYSNYLH
                     LMTSEQIGMNTLLGYSQVWTRLSDTGGTLASDIMLGYRYYVASKAGSWGKDMAEDSLWP
                     LAETEKFTLWENASVGDRAFFIPKEDYEAYAATEAYTENVFENQNRLSELLFHTTPIDW
                     EKETYADDETGAELSYRFHADGKQILYLYGKDLQQAEITVNGKRIYVPDYNDLYNESYP
                     ATGNGGILSLGCFADEDITVDIRQSVGNSGAERAVFFGFLDQQELLEAADTAGRAVTYE
                     LDRDSCKLTVESAGEEYLMLPINADGGWYCTVNGEEWTVSRLAGNLMLVPLDAGTNEIT
                     LCYVPRGMKKGAAVTGIALMLLAGWGVLSRLLRRKSVLDKIYAGLGCAAADIFAVVYAG
                     FLLVVYVIPVVYTIYLRWI"
     CDS             12467..13951
                     /locus_tag="ctg10_8"
                     /transl_table=11
                     /translation="MEKLQARKKVYLWLLILLSLCALIPLAVLSKYNHQSGDDYGYAYR
                     TFQIWRETHSFWNVIKEAFATSAEFYQKWQGLYASAVLLALEPGIFGDKYYALTGILLL
                     AIIVGANCAGTVYIFHRKCGCPRLEGFAAGCVMSFLMIEWMPSALQGLYWYNGAMNYVF
                     FHAVLLLLLCVLLSLAGEHPRRKAGRTVLAVLLAVLLAGGNHVTAFVGILLIVGFGIFA
                     AVKKRRQNLICCVITLAAMVAGFLFNVTSPGTRIRQSYFSDRPGVAGTIVTAVKTGIAC
                     INSWMGLAVIVTAVLLLPVLLPLVKKIRGQYGFSFRYPLLVFVLSVAWLCAMFCPPIYA
                     MGTPGDVRLTNVVYFSFVWLFVLNEAYLCGWAVTRLEASGAAALSGAAGEFPGSFLITA
                     AVLAVGMIIGCGENMTAWQAYLLIRSGEAQEYSAEADERYAVLCDSAGEDVVLKAYTAK
                     PWMLFLDDITEEKSDWRNEYMRVYFGLNSVVLEQTE"
ORIGIN
        1 gtccgctcat tgtctgcagc ttgtcggaca cactccgtga gtgtccaaac gtggcaaaga
       61 cacggaatgg gatgccagcg gcggtatgga agaaatactc gaattttgct tcaaagaatt
      121 tgccgccgtc tgtttattct ggaacttttt tgttctctag tattcctgta atattactta
      181 tcacgaaaag gggctgcaca tttgatgcgc agcccctttc tctgtatctg tcagcctgca
      241 gcctgatcct tctgctccgg tgcgttctgc tttgccagat ttttgttcgc ggtggagagc
      301 atcagcttga tacggttgag ctggtttacc tcgctggcac ccggatcgta atcgatggcc
      361 acgatattgg aacccggata gcggtgacgc agttccttga tgacgccctt gccgaccaca
      421 tggttcggca ggcaggcgaa tggctgcgtg cagacgatgt tcggtgttcc ggtgtggatc
      481 agctctaaca tctcaccggt taagaaccag ccctcgccgg tctggttgcc ctcggataca
      541 atgtctcttg catatctggc aagatcatcg atgtgcgcag gtgcagtaaa gtgcctgctc
      601 tttgtgaatt catctcttgc agcgctgcgc agccactcaa agaaattgat gcccagacgg
      661 ccgatcttct tggacttctg gctcatgccg agattgtctg ctttaaagcc cgtattgtag
      721 aagcagtaga gcaggaaatc ggtcagatcc ggtacaacgg cctctgcacc ctcggattcg
      781 agaagctcca ccagatgatt gttggcagcc ggatggaact tgacaagaat ctcgccgaca
      841 acgccgacgc gcggtttctt gatgtctttg cgcggaaggt tgtcaaaatc gcggatgatc
      901 tcgcggcaca ttttcttgaa cttgccgtgg gagagcatct ttttctgggt aataaaggcg
      961 ataacctctt ttttccattt ctcgtgcaac tcgtccgttg atccggcaac cgcctcgtaa
     1021 gggcgcgttg cgtagacgca gcgcatgaag atatcgccaa actccagcgc gtagagtccg
     1081 tgctggatca gtggcagtgt cagcttaaag cccgggtttt tctccagacc gctcagattg
     1141 atcgagatga ccggaacgtc cggatagccg gctttttcca gtgcacgccg gatgaagccg
     1201 atgtaattgc tggcgcggca gccgccgccg gtctgggaga ttaagaccgc ggtgcgcgac
     1261 atatcataac cgccggacat cacggccgcc atcagctggc caaccacgat cagggacggg
     1321 tagcaggcgt cattgttgac gtactttaag ccgacatcca cgcaggtacg gctgtccaca
     1381 tccggaacaa caaggttgta cccggccgtc tggaacgccg gctccaacag ctcaaaatgg
     1441 atcggtgaca tctgtgggca gaggatggtg taattcttgc gcatttcctc cgtgaagacg
     1501 acgcggttgt aattcgccgg aacgatggtg cgcttcgtct gcttcttctc acggacacgg
     1561 atcgccgaga tcagggaacg gatacggatg cgcgccgcac caaggttgtt gacctcatcg
     1621 atttttaaac aggtgtagat cttgccggac tttgtcagaa tatcattgac agcgtctgtc
     1681 gtgacggcgt ccagaccgca gccgaaagaa ttcagctgga tgaggtcgag atcgtctctt
     1741 gtcttgacat agttcgccgc agcgtacagt ctggagtgat acatccactg atccatgacg
     1801 atgagcgggc gctccaccgg ctgtaagtgg gagatggaat cctccgtgag cacggcgatg
     1861 ccgtaggagg taatcagctc cggaataccg tggttgatct cagggtctac atggtacgga
     1921 cggcctgcga ggacgatacc gcgtcttccg gtctccttta aatactgtaa gacttcctcg
     1981 ccttttttct gcatctccat ccggcagacg gcaagctcct tccagccttc ggcaaccgcg
     2041 tcgcggatct cggattccgg aatcccgaac tccgactggc caaaggtctt aatcagctgg
     2101 gaggaaagcg tctcctcgct ggcgaaagac ataaacggat ttaagaactt cacctgaccg
     2161 gaagtgatct cgtccacgtt atttttgata ttttccgcgt aggaggtaac gatcggacag
     2221 ttgtagtgat tgttggaatc cgggaattcg ttgcgctcat aaggaataca cgggtagaaa
     2281 ataaaatcga cgttctggtg gatcagccat gtcacatgac cgtgtgccag ctttgccggg
     2341 tagcactcgg actcgctcgg gatggaatca attccaagct cgtagatctt gcgcgtcgac
     2401 tgcggggaga gtaccacgga aaaaccgagc ttcttaaaga aagttgccca gaacgggtag
     2461 ttctcgtaca tatttaaaac gcgcggaata ccgactgtgc cgcgtgctgc ttcctcggcg
     2521 gaaagcgggg tgtagtcaaa caggcgcttg ttcttgtatt cgtagaggtt tggaatgttg
     2581 tctttatttt tctccttgcc gaggccgcgc tcacagcggt tgccggtgat atactggcgg
     2641 ttgccggaaa agcggttgat tgtgaggaga cagtggttgg tacatccctg acatcttgcc
     2701 agctttgtgt cgaaggtcag cgcattgatc tgttcgatgg aaagcatgga ggtctggtag
     2761 cctgcctcgt gacgctctct ggcgatcagt gcggcaccga aagcacccat gatgccggca
     2821 atatccggac ggacacattc gacacccgca attttctcaa aactgcgcag tacggcatcg
     2881 ttgtaaaacg taccgccctg tacgacgata tttttcccga gctggcttgc atcggaaagc
     2941 ttgattacct taaataaagc attcttgatg acagagtacg caagacccgc agaaatatct
     3001 gcaacggatg cgccctcttt ctgcgcctgc tttaccttgg aattcataaa tacggtgcag
     3061 cgggttccaa gatcgatcgg atttttggca aaaagagcct cctttgcaaa atcctgtaca
     3121 gagtagttga gggattttgc aaacgtctcg atgaaagaac cgcagccgga ggaacaagcc
     3181 tcattgagct gtacggaatc caccgtctga ttcttgatct tgatacattt catatcctga
     3241 ccgccgatgt ctaagataca gtcgacttcc gggtcgaaga acgcggccgc atagaaatga
     3301 gccaccgtct caacctcgcc gtcatcgagc atcaaagcgg cttttaacag cgcttcgccg
     3361 tatccggtgg agcaggagtg gacaatcttt gccttcggtg gaaggagcgt atagatctcc
     3421 ttgatggaac ggattgccgt tgcaagcgga cttccgttgt tgttgctgta gaaagaatac
     3481 aaaagggaac cgtcctcgcc gactaaggca atcttagtcg tggtggaacc tgcatcgatg
     3541 cccagatagc agttgccctc ataagtggag aaatctgcgg acctgacatt gtgtccgtcg
     3601 tggcgcgcac ggaaagcgtc gtactcttcc tggctggcaa acagaggatc catacgggca
     3661 acctcaaatt ccatcttgat gccgttcgcg agccggtcgc ggagagagac gagcgtggtc
     3721 gtctcacccg gcttgtaatt taaagcggaa ccgatcgcag caaatagatg ggaattctcc
     3781 ggtgtgatgg cgtgttcgtc gtccagattc aaggtgcgga taaaagcagc cttgagctcg
     3841 gaaaggaagt gaagcggacc tccgagaaag gcaacgtggc cgcggatcgg cttaccgcag
     3901 gcaagaccgc tgatcgtctg attgaccacc gcctggaaaa tggaggcaga gagatcctct
     3961 ctggtagcac cctcgttgat taacggctgg atatcggtct tggcaaagac accgcaacgc
     4021 gcagcgatcg ggtagatggc cttgtaattc ttggcgtatt cattcagacc tgtcgcatcc
     4081 gtctggatga gggatgccat ctggtcgata aaagaaccgg taccgccggc acagatgccg
     4141 ttcatacgct gctcgacatt gccgccctca aaatagatga tcttggcatc ctcaccaccg
     4201 agctcgatgg caacatcggt ctgcggtgca taatgctgca gggcagtgga cacggcgatc
     4261 acttcctgga caaacggaac accgagatgc ttggcgagtg tcagaccgcc ggaaccggta
     4321 atcatcggtg caacagcaaa gtcgccgagt gcatcgtaag ctttctggag aagggaggat
     4381 aaggtctcct ggatattggc aaaatggcgc tcataatcag agaagagcag atgatcctcc
     4441 tggtctaaaa ttgcgacctt gacggttgtg gaaccgatgt cgattcccaa tttatgaagt
     4501 gtattgtttt ccataattcc ctccatggct gtttctcgta aagtaaatac tttagcagag
     4561 taaaatatgt aaaagatttc ttcttattat aaatagtgcc aatctggcga taaacactct
     4621 acattatacg acaggatatg tcaaaagaca atgtgcattt tgccggaaaa gtataaactt
     4681 tttgtaaaga agaatccctc tgattgacaa agatttcccc gaccgatata ctgaacaacg
     4741 taatgtcatt tttggaaagg tcaggaacag agtatatgaa ctggttaaat aaattagaac
     4801 gtaaattcgg caactgggcg attcccaatc tgatcgtgtg gctgatcgga gcttacacga
     4861 tcgggtttgt gctctaccag gtgaatccgt cgatcatagg acttttgatg ttgagtccgt
     4921 atcacatcct gcacggacag atctggcgtc tgattacctg ggtgtttatg cccacagaca
     4981 cgaatctggt gtatcttctc attatggcgc ttttctatta tcagcttgga acgacactgg
     5041 agcgcacatg gggaaccttc cggtttaacg tctatatttt cggaggtatg ctgtttaccg
     5101 tcatcggagc gtttttgctg tacggtatca tgtatctttt gaacggcggt gtgacgacgg
     5161 agatgcttct catcggaacg agtttcagca caagttacat caacatgtcc atcttccttg
     5221 cgtttgcatg tatgtatccg gatatgcagg ttcttctgat gttcattatc ccgattaaga
     5281 tgaagtggat ggcggctgtg tacggcgttc tgattgcttt aagctttttt gagaccggat
     5341 gggcgggaag aatggcgatt tttatgtcgc tcctcaactt tattattttc ttcttctcca
     5401 ccagaaacct caagcgctat acgccgcacg aggtgcacag acgccagaag tttaaggcag
     5461 acatgcgaag accgcaggga tatgcgggcg gtgcgaagca caagtgtgct gtctgcggca
     5521 ggacggaact tgacgatccg acgctggaat tccgtttctg ctccaagtgc gagggcaatt
     5581 acgaatactg tcaggatcat ctgtttacac atcagcatat tcggatgagc tagaaagtat
     5641 gaaaaagaaa aaggtgatac ttcgattccg ccagccggtg gagaagaagt atcacctttt
     5701 tgtttctttt aggagtagaa atcttttagc gcatccatcc gtgcactcat attggaaaaa
     5761 agtgcgtcga cgatcgtgat ggctgccatg gattccacca cgacaacggc gcgcggaacg
     5821 atgatcggat cgtggcgtcc cttgatgttg accgagatct cctccccgga ctgattgaca
     5881 gtgcgctgtg tggcggcgat ggaaggggtc ggcttgatgg cagcccggag gatgatgtcg
     5941 cttccgtcgc tcatgccgcc taagataccg ccggcatggt tggttgcttt ggcaatcctg
     6001 ccgtcctcac cgaggacaaa ggcatcgttg ttgttcttgc cggtcgcttt tgccacgtca
     6061 aatccgtccc cgatctcaaa acctttgacg gcgccgatgg acatgaccgc cttggcaagg
     6121 ttcgcattaa gcttctcgaa gaccggatct ccgatgccgg cgggcatccc ctttatgata
     6181 cactccacaa tgccgccgga ggaattcagt tccgccatgc aggcatccag atagttttcg
     6241 gcgttctcgg ctgcctcggc gtccggcata tagagcggat tcttcgtgac ttcggaaaaa
     6301 tcaaagcgcc cggaagatac ggcgatcggg ccgatggatt ttgtgtaggt tataaaggta
     6361 atgccgagct cgtttagaat cttgacggcg acggcgccgg cggcgacacg cccgatggtt
     6421 tcccgcccgg aggagcgccc gcccccgcgg tagtcgcgga agccgtattt ctggtcgaac
     6481 gtgtaatcgg cgtgaccggg acggtaatag gaggcaatct cgctgtagtc tctggactgc
     6541 tggttgcggt tgaagacgac aagcgagatc ggggtgccgg tcgtctttcc ttcaaacacg
     6601 ccagagagaa tctctacggc gtcgtcctct ttgcgcggcg ttgcatatct ggactgaccg
     6661 ggcttgcgcc ggtcgagaaa cttctggata tccgcctcac agagagaaag tcccgccgga
     6721 cagccgtcga tgacgacgcc gacgcccttt ccgtgagatt ccccccaggt tgtaatttta
     6781 aaaagagttc ccaaagtaga acctgccatg tgattccctc ctgcttacat aatgatcttt
     6841 ctcgattata aaagatttga ctttgcgccg caacagaaat atgttatgat ttgacggagc
     6901 agaagtacca gcaggcgagg agaagaatat ttcatgatag agaaatacct tgtgaaaaag
     6961 ataacagagc cggtggactg gaaggtaacc gtgccgggat caaagagcat gacgaaccgc
     7021 gcgcttctta tggcagtgtt gtccgcaggg acggtgcgcg tggaaggagt cctgttttcc
     7081 gatgattcca gacactttct ggcgtgtctt gtggcgctcg gctttacagt ggagatagag
     7141 gaagaaaaaa agtgcgtgac cgtgacgggc tgcggcggca ggattccccg cggggaggcg
     7201 gtaatcgacg tcggaagcgc cgggacagcg gcgcgttttc ttgcggcgat gctcggattt
     7261 tcggacgggt gctatgagat ccgctgctca gcgcagatga agcggcggcc gatggcggag
     7321 ctgttcgatc tgctttccgg tgtgggagcg aagattacat tcctcgagga ggaagggcat
     7381 cttccggtgc gcatcacagg atgcagatac gcccgggcgg ataagacagc aggggagacg
     7441 ccgcgggagc tctctcttga cattacgaag agcacacagt ttttaagcgc gctgctgttg
     7501 attgcgccga tggttccgga agggatgaag atccacatca ccagtgagaa gacggacggc
     7561 tcatacatcc gcatcacgcg gaagatgatg caggaattcg gcgtgagtgt cgcttttgac
     7621 ggaagagact acgaggtgcc gtgcagaagt tcctaccgga aagagactta tatggtggaa
     7681 ccggatatgt cggctgcctg ctatttttat gcggctgcgg ctgtgaccgg cggacgggcg
     7741 cttgtgcggc atgtgcatat ggacaacata cagggagatc tgcgtttcct ggaagtgttg
     7801 gagcacatgg gatgtaccgc ggacgatacg ccggagggcg tcctggtaac ggggccggcg
     7861 gacggtgcgc tgcggggcat cacagtcaat atgaacgatt tttccgatca ggcgctgacc
     7921 ctggcggcga tcgcgccgtt tgccgacgcg ccggtgcgca tagagggaat cggacatatc
     7981 cgtgggcagg aatgcgaccg gattcacgcg atacagacga acctgacagc gcttggcatc
     8041 cggtgtgagg aggaagagac ggctgccacg atctatcccg gcagccccca cggtggaagc
     8101 gtggagacat acgacgatca ccgcgtggcg atggcatttt ccctggtcgg acttagaacc
     8161 gacgggattg tcattgagaa cccggcgtgc tgccgcaaga catttgaaga ttactttacc
     8221 gtgttaagcg aactgaccgg gaagaagacg gaggcgtgaa gcagcgccgg ctttgcatga
     8281 gtaataaaaa ggagacgaaa aacagatgta tgaattatta aaacaggaag gacgcgcgaa
     8341 gagaggcgtt ttccatacgg tgcacggaga tatccagacg ccggtattta tgaatgtggg
     8401 tacggtggct gccatcaagg gagctgtctc cacggaagat ctggaacaga tcaagtgtca
     8461 ggtggagttg tcaaacacct accatctgca tgtgcgcaca ggggataaac tgatcaggga
     8521 agtgggagga ctgcacaagt ttatgtcgtg gaatcgtccg attcttacgg attccggcgg
     8581 atttcaggtg ttctccctgg caggcctgcg caagatcaag gaggagggcg tctatttcca
     8641 ctcgcatatt gacggggcaa agattttcat gggaccggag gagagtatgc agatccagtc
     8701 caatctcggc tccacgatcg ccatggcatt cgatgaatgt ccgccggcgc ttgccgagcg
     8761 gaaatatgtg gaggattccg tggcgcggac gacgcgctgg ctggagcgct gcaagaacga
     8821 gatgcagcgc ctcaacggtc tggaggatac cgtgaaccgt caccagatgc tgttcggcat
     8881 caaccaggga gccatctaca cggacatccg gatcgaccat gcaaagcgga tttccgagct
     8941 ggatctggac ggctatgcgg tcggcggact tgcggtcggc gagacacacg aggagatgta
     9001 ccatgtgctg gatgagaccg tgccttatct tccggtgaac aagccgacct atctcatggg
     9061 agtcggaacg ccggccaata ttctggaggg agtggagcgc ggcattgact tcttcgactg
     9121 tgtttatccg tcccgcaacg gccgacatgg ccatgtatac acgaaccagg gcaagatcaa
     9181 cctgttcaac cagaagtacg agaaggatat gcgcccgatc gaagagggct gcggctgccc
     9241 gacctgccgc cgctacagca gagcctatat ccgccatctg ctcaaggcaa aagagatgct
     9301 tggcatgcgc ttatgtgttc tgcacaatct gtacttctac aacacgatga tggaagagat
     9361 ccgggatgcg ctggatgccg gaaactttgc ctcctacaag gaagaaaagt tatacggcat
     9421 gggacagatc aaccgggaaa aggaaatggc aaagtaaaag ggaaaaggct tgccaaacag
     9481 cgaggttttg tgtacaatac tctttaatga agtcggatga cttcggacaa gtttatgatt
     9541 ttaggaggat atcagatgtt ttcaatctta gcaacagaga gtgcgtcatc cgctggctgg
     9601 atcagtatgg tggtgtggct ggttatttta tttgcgttta tgtatttctt catggttcgt
     9661 ccgcagaaga aggaacagca gaagaagaac tccatgcttg cagaacttgc agtgggagat
     9721 acgatcttaa caacaagcgg tttttatgga acagtgatcg atattgctga tgatacagta
     9781 atcgttgagt tcggaagcaa caagaactgc cgtatcccga tgcagaaggc ggccatctcc
     9841 gcagttgaga agccggaaga tgtaactgaa taagaagatt tttaagaggg atagtatata
     9901 aagtgtatta tcccttttct ttttgagaga gtatttcgga gagcgaggag agattgtccg
     9961 gatgaaaaga aaaaaaaata cgtttgtttc acgtgccgcc gtcggctgcg tgacaactgc
    10021 catttttctg ctgttgtgca tcataaaggg catctatccg tttggaattg ccacgcttga
    10081 cactgtggat tttcagtccc agtggattcc ggcatattac catgtatggg atgtgctgca
    10141 cggagacggc agcgcctttt ttgactggag agtcggcggc gggaataatt ttgcgggagt
    10201 gagcgcgcag ttttctctgt tcagcccgtt taacctgttc ttcctctttg tgaaaagaag
    10261 ctggattgaa aaatccatga tcgtgtttct tttaatcaag ctgcttgcca tgggctatgg
    10321 catgcgctgg tttttaaaag agcagatcct taaggaagag cgttacggaa tctacattct
    10381 ggcgggaagc gtggggtatg ccgtaaacgg ctatacgctt ttgtactatg gcatgggctg
    10441 gctggatgtg gcagcgatcc tgccgctatt gtgttatttc ttctgcagga tggcggagcg
    10501 ggaaggggac tggcgtctcg ggaaaaatac gctcggctat atcgtctgcc tgacgctggt
    10561 attcatcatc aatattccgc aggcgtacat gatgtgcttt ttcctgatcg tgtttgcggg
    10621 gggatatttt ttcctgaacc ggcaggacca gccgctaaaa aagaacagca ttttaaaatt
    10681 cgggctgact tctttactgt cgcttggaat tgcggcggta atatttctgc cggcagcgag
    10741 ggcaatgctt ggttcctacc ggctgtcggg cgaggagtac cggggaatct ccggctattt
    10801 tctgctgctt cggcaggacg gaatggacgc ggtgtggaaa tgggtgattc ttggcagcgt
    10861 ggcggttccg ctgctgttct tcgtcatttc cggcagacgg aaatgggagc acatctggca
    10921 gtggtatctg gtgacggcga tggtgctgcc ggttctcttt gaggcggtca acctcatctg
    10981 gcaccgcggg acgtatgtgt gttttccaat gcgctacggc tatatgctgg tgtttgccgt
    11041 gatttatatg gcagcggcgc gtgtgccgga ttttgtgggg gagagccgca cgcggcggaa
    11101 cattttatat gcgttcctgg gaatctggtg cgtgcagatg gtggcgctcg gcatcgcttt
    11161 gatacagccg gagccgcaca tggacgagac ggattttgtc ggggatgcca cggaaatcgg
    11221 tcagccgctt gccgggaaaa ccgatatttt ccacaaggca aagctggcgg acggagcgat
    11281 tgacaacaat tatccgctga tcgcagagag cacctcctac tctaactatc tgcatctgat
    11341 gacatcggag cagatcggga tgaacacgct gctcgggtat tcccaggtgt ggaccagatt
    11401 aagtgacacg ggcggaaccc tcgcgtccga tatcatgctg ggataccgct actatgtggc
    11461 gtccaaagcg ggctcgtggg gaaaagacat ggcggaggat tctctttggc cgcttgcgga
    11521 gacggagaag tttacgctgt gggaaaatgc gtccgtcggg gacagggcat tttttatccc
    11581 aaaggaggac tatgaagcgt atgcagccac ggaagcgtac acggagaatg tgtttgagaa
    11641 ccagaaccgg ctgtcggagc tgctctttca cacaactccc atcgactggg aaaaagagac
    11701 ctatgcggat gatgagaccg gagcggaatt atcgtaccgg tttcacgcag acggaaagca
    11761 gatcctatat ctctatggaa aggatctgca gcaggcagaa attacggtaa acggaaagag
    11821 gatctatgtc ccggattaca atgatctgta caatgagagc tatcctgcaa ccggcaatgg
    11881 gggaattctc tccctcgggt gttttgcgga cgaagacatc acggtggata tccgccagtc
    11941 cgtcgggaac agcggcgcag agagagcggt gttcttcgga ttccttgatc agcaggaact
    12001 gctggaggcg gcggatacag cgggaagggc ggttacatat gaactggatc gggattcctg
    12061 taagctcacc gtcgaatcgg cgggagagga gtatctgatg cttccaatca atgcggatgg
    12121 cggatggtat tgtacggtaa acggagagga gtggaccgta agccggctcg cgggcaatct
    12181 gatgctcgtg ccgcttgatg cgggaacgaa cgagatcacg ctttgctatg tgccgcgggg
    12241 aatgaaaaag ggcgcggcgg tgacgggtat agccctgatg cttctggcag gctggggcgt
    12301 tctctcgcgt ctgcttcgga gaaaaagtgt cctggataaa atctacgccg gacttggctg
    12361 tgccgccgca gatatttttg cggtggtcta tgccggattt ctgctggtcg tctatgtgat
    12421 tccggtggtg tatacgatat atttaagatg gatctgaggt aacagaatgg aaaaattaca
    12481 agcgagaaaa aaagtatatt tgtggctgct gattttattg agcctttgcg cgctgatccc
    12541 gttagccgta ctctcgaagt acaatcatca gtcgggggat gactatggtt atgcctaccg
    12601 caccttccag atctggcggg agacacattc tttctggaat gtgataaaag aagcgtttgc
    12661 cacatcagcg gagttctatc agaagtggca ggggctttat gcatcggcgg ttctgctggc
    12721 gctggaaccg ggaattttcg gcgacaaata ttacgcgctg accggaatct tgctgctcgc
    12781 aattattgtg ggggcaaact gcgcgggtac ggtttatatc tttcaccgca aatgcggctg
    12841 cccgagactg gagggatttg ctgccggctg tgtcatgtcg tttcttatga tcgaatggat
    12901 gccctccgcc ctgcagggat tgtactggta taacggcgcg atgaattatg tattcttcca
    12961 tgcggtgcta ttattgttgt tgtgtgtgct gctcagcctt gccggggagc acccgcggag
    13021 aaaagcaggc aggacggtgc ttgcggtgct gcttgcggtg ctgcttgccg gcgggaatca
    13081 cgtgaccgca tttgtgggga tactgctgat tgtcggattt ggaatatttg ctgcggtaaa
    13141 aaagcggcgg cagaacctga tctgctgcgt cataacgctt gcggctatgg tggcgggatt
    13201 cctttttaat gtgacgtcgc cgggcaccag aatccggcag tcgtattttt ccgacagacc
    13261 cggtgtggcg ggaacgattg ttaccgcggt aaaaaccgga attgcatgca tcaacagctg
    13321 gatgggactt gcagtcattg tcacggcggt tctgttgctt ccggtgcttc ttcccctggt
    13381 aaagaagata cgcggacagt atggattttc gttccgctat ccgctgcttg tctttgtgtt
    13441 gtcggtcgcc tggctgtgcg caatgttctg tccgcccatc tacgcgatgg gaacgccggg
    13501 ggacgtccgg ctgaccaacg tggtatattt ttccttcgtc tggctgtttg tgttaaatga
    13561 agcctatctg tgcggatggg cggtcacaag actggaggcg tccggggcgg cggcactgtc
    13621 cggggctgca ggagaatttc cgggcagttt tttgatcacg gctgctgtcc ttgcggtggg
    13681 aatgataatc ggatgcgggg aaaatatgac cgcatggcag gcatacctgc tgatccgcag
    13741 cggcgaggca caggaatatt cggcggaggc tgatgagcgc tacgccgttt tgtgtgattc
    13801 tgcgggggaa gacgtggtgt taaaggcgta taccgcaaag ccgtggatgc ttttcctcga
    13861 cgatattaca gaggagaaaa gcgactggag aaatgaatat atgcgcgtct attttggact
    13921 gaacagcgtt gtgttagagc agacggaatg agacggcaga agggagcagc ggacacaaaa
    13981 ggcaggctgc tcctttttca taagacccgg ttatagggag tatgaaaaag aaaaatagat
    14041 tcagaggttg cattgtttcc cgagatacat tattatagaa tttatatact gtctgttagt
    14101 aatgtactaa agtcaataca agacggattc ctgcacggca ggaagaaaag agggattaga
    14161 gagatggaat ataaggtagg cgtgatttcc ggcgacggga tcggaccgga gatcgtaaca
    14221 gaggcaaaga aagttctgga tcagcttgga aagatctacg gacatgtgtt ccgctatgaa
    14281 gagattctga tgggaggctg ctccattgac gcgacgggtg agccgctcac ggatgcggcg
    14341 atcgcttccg cgaaggcttc cgatgcggtg ctgatgggat cgatcggcgg caacacatcg
    14401 acttcgccgt ggtatcagct gccgccggag aagagaccgg aggcgggact tttaaagctc
    14461 cgcaaggcgc tgaacctgtt tgccaactta agaccggcat atttatatga agaa
//
