LOCUS       gnlProkkaKFBOLDAB_9    12104 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KFBOLDAB_9.
ACCESSION   gnlProkkaKFBOLDAB_9
VERSION     gnlProkkaKFBOLDAB_9
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 08:13:57
            Original ID  :: gnl|Prokka|KFBOLDAB_9
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12104
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12104
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3592:4081]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3593..4081
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..12104
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12104
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(103..474)
                     /locus_tag="ctg9_1"
                     /transl_table=11
                     /translation="MKSFAKLIEDLGGTTYTCYMELGQPEDISNLYFSKYEIPKDLKIL
                     SVGILPYEMLEFIYIEENQNECFESETLLRHYINMLPLIMACSVKKADKENKSKQNLKG
                     ECPEEYYLKRQQDYRSNIN"
     CDS             complement(474..707)
                     /locus_tag="ctg9_2"
                     /transl_table=11
                     /translation="MGMKDGKEGFKAVHEYLVNGGKSCMAGFVLKNTLSDNGGVTRGIC
                     KMDTENVSVEIIDFSNEAQLNMYTKKELIGLV"
     CDS             complement(676..1707)
                     /NRPS_PKS="Domain: NAD_binding_4 (4-182). E-value: 5.2e-11.
                     Score: 34.0. Matches aSDomain:
                     nrpspksdomains_ctg9_3_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     234.4; E-value: 3.3e-71)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_3"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.4e-08, bitscore:
                     22.4, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.4e-19,
                     bitscore: 59.4, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVLVTGGAGYIGSHTCVELLENNKEVVVLDNLSNSSEEALNRVK
                     RITGKEVKFYKGDISDIVILDTIFKKENIESCIHFAGLKSVGESVAKPLEYYQNNIAGT
                     LILLQKLREYNVKNIIFSSSATVYGDPAFVPITEECPKGLCTNPYGWSKSMLEQILMDI
                     YKADETWNIILLRYFNPIGAHKSGLMGENPNGIPNNLMPYVTQVAVGKLKELGVFGNDY
                     DTPDGTGVRDYIHVVDLAKGHVKALQKIDEKCGFKIYNLGTGKGYSVLDIVKNFEAATG
                     MKVPYVIKDRRPGDIATCYCDPGKAAKELDWKAENGIKEMCEDSWRWQKKNPNGYEGWK
                     RRI"
     aSDomain        complement(1162..1695)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg9_3_NAD_binding_4.1"
                     /evalue="5.20E-11"
                     /label="ctg9_3_NAD_binding_4.1"
                     /locus_tag="ctg9_3"
                     /protein_end="182"
                     /protein_start="4"
                     /score="34.0"
                     /tool="antismash"
                     /translation="VTGGAGYIGSHTCVELLENNKEVVVLDNLSNSSEEALNRVKRITG
                     KEVKFYKGDISDIVILDTIFKKENIESCIHFAGLKSVGESVAKPLEYYQNNIAGTLILL
                     QKLREYNVKNIIFSSSATVYGDPAFVPITEECPKGLCTNPYGWSKSMLEQILMDIYKAD
                     ETWNIILLRYFNPIG"
     CDS_motif       complement(1636..1701)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg9_3_0001"
                     /evalue="2.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg9_3"
                     /protein_end="24"
                     /protein_start="2"
                     /score="13.5"
                     /tool="antismash"
                     /translation="VLVTGGAGYIGSHTCVELLENN"
     CDS             complement(1797..3182)
                     /locus_tag="ctg9_4"
                     /transl_table=11
                     /translation="MGKYFGTDGFRGEANVNLTVDHARKVGRFLGWYYGQLKKQRGDDI
                     PAKVVIGKDTRRSSYMFEYALVAGLTASGADAYLLHVTTTPSVAYVARTEDFDCGIMIS
                     ASHNPYYDNGIKLINGNGEKMDEATINLVEAYLDSELEVFGQKYEEIPFAHKDAIGCTV
                     DYAAGRNRYMGYLISLGLYSFKGMKVGLDCANGSSWNMAQQIFDSLGAKTFVINAEPDG
                     TNINRDAGSTHIEGLQKYVVENGLDVGFAYDGDADRCLCVDEKGNVVDGDAILYIYGKY
                     MKERGKLLTNTVVTTVMSNFGLYKAFDELGIGYAKTAVGDKYVYEYMTKNGCRIGGEQS
                     GHIIFSKYASTGDGILTSLKMMEVMMAKKKKLSQLTEDLHIYPQILVNVMVKDKAVAQA
                     DADVQAAISKVAERLGDTGRILVRESGTEPLIRVMVEAETKEICHTYVDEVVSIINKKE
                     ATR"
     CDS             3593..4081
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_5"
                     /sec_met_domain="PF05402 (E-value: 7.1e-12, bitscore: 35.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 4.1e-09,
                     bitscore: 26.4, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKCQPGYTLRKIKGISYLLPYGQQIADLKKGFVLNETSTFLWNV
                     LQHHEGAEPQQLAEILARTYQLDESYYPELLKDVTDFLTQLTAMGMITEDLHLISSIPS
                     VSMIIAGICIKLYGSAELISPNFKPFYHKFSDDDTSQEIELVTTPPPSRCYGQVLLQK"
     CDS             4078..4752
                     /locus_tag="ctg9_6"
                     /transl_table=11
                     /translation="MTVFENPDRYVVLFPQMQNLYEAHMLKDGTYVRVYCHPQVSETNI
                     ENLFHAIRLFFLFTAQRNGLFAIHSASVLYQGKAWLFSGHSGMGKSTHTALWHELFDTP
                     YLNGDLNLLGLKEDHIIVYGIPWCGTSGIFIAEAYELGGIVLLGRDLQTDYLEELNPSE
                     KVLRVMQRMISPAWTERQLSENLFFAGEIADRVPVLHLLCTKNASAACVMKNAIDQLEE
                     LQ"
     CDS             4749..6518
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 278.8; E-value:
                     1.6e-84)"
                     /gene_kind="transport"
                     /locus_tag="ctg9_7"
                     /transl_table=11
                     /translation="MKEKILLIWKHLKQGTLKKMWKQTLWIYQYGRRYWKAMILYTLLG
                     LVGTGVSLVSSLISRDLVDIITGHQTGKLISTFAAMIGFSVANILVSQASGYASTFINL
                     KVDSEIKNDIFAKMLVTDWESLTDYHTGDLVTRWSSDASNISSGILNWIPNLIIYTFRF
                     ISALAIVLYYDPTFALFALLGIPFSALLSKPLLKRMRDNNQRSAAMNAKLYGFNQEAFS
                     NIQTIKAFDLIHFYTEKLKSLQKDYVNMRLDFQKMSILTSVLMSIIGFIVSYSCYGWGI
                     YRVWSNAISYGTMTMFLSLSGTLTSSVNSLVSLIPAAISLTISAGRLMDIVEMPQEDYS
                     QDSAVRNFEKQHKSEGIGLNMQDLSYTYHNGTAVFANASIEAYPHEIVALVGPSGEGKT
                     TMLRLILSLLTPQEGSSHICAGTDHEHMIDMSPSTRKLFSYVPQGNTMFSGTIAENMRN
                     VKQDATDEEIIEALKLACAWDFVEKLPDGIESIVKERGGGFSEGQAQRLSIARALLRRS
                     PILLLDEATSALDVATERKVLRNIMQDTYPRTCIVTTHRPTVLNICNRVYAIRDKKCEI
                     LNDVEIHEMIQTF"
     CDS             complement(6586..6969)
                     /locus_tag="ctg9_8"
                     /transl_table=11
                     /translation="MKSYKKPVVTVDAGMAEGVYAASGASQGTLNVTYHGVWDRWGTNG
                     GKGLAMADWSGINGTITLNITFNDTLDQVETDDASVQESWSGKTATLTFASTASNPLTI
                     GVHIDHGASIDDLKMTGFTYSVN"
     CDS             7111..7656
                     /locus_tag="ctg9_9"
                     /transl_table=11
                     /translation="MSFCFLNVIIRLFRTLFLNRRIITGIRTDTMNNPTSDPVKIDLEQ
                     LLREGNIIRIKPQGYSMYPLFIPGRDEALIQQTDGTDCHRNDVVLYRRDQGILVLHRIC
                     RITSDGFYMVGDNQYEVEGPLRQDQIVGKLIAVNRNSREFTVGNPFYKFVSSLWLFMLP
                     VRPFCFKLSAFLRKLHHS"
     CDS             complement(7668..8006)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_10"
                     /sec_met_domain="PF05402 (E-value: 3.6e-15, bitscore: 46.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVINNSKYIMLLRENKGKGREKGKMKKTEGYVVRRMEDEYLVLP
                     SGRRTEEVNEVISLSETAGFIYMHAERAKNVDELAQLVAEEYEIELAEVLEDVRNVVLT
                     LQKKGILL"
     CDS             8053..9246
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_11"
                     /sec_met_domain="NTP_transf_5 (E-value: 3.1e-39, bitscore:
                     124.8, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERIYNTYLKIIRNICTGSDHSVSVHPEDLAALAKLAQEHCTVPF
                     VLPYLRSASVYPAMKQQVKGMMLNYYQIEHFTRLTVSLLKKNNIDCYLLKGLSLADCYP
                     VPEYRKLGDLDLYLADPSDLARAQAILESNGYISEDELSDHHVTYRYIFPKTGRRFLLE
                     LHYRVVGQYQYSPANKLVDSVFSPECLKASTQTIHGYTYTVLPPTEYTFYMIHHMLKHY
                     LYSGFGIRLLCDFTFYLKRHEKEINFRQIHEWCRESRISHLYEIILECCRKYLGLPDSI
                     DARTQYNPHDCHDFIIQILKDGDMGTDISQSLVGSSSYQKVNFLTYFKEGHIQMKVRFP
                     KASHYPVLWPALWCITFICFIRNTYTVRNTTFRQTLHDFKKNNQKTKLIRIFENSDF"
     CDS             complement(9263..10354)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_12"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.2e-39,
                     bitscore: 125.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALEKQQKKISVIIPVYNAEKYIRETLDSIIKQSYKTLEIILID
                     NGSKDRSPDIIQKYEAKYPEIHMIEGSGKGPGASRNRGLKIAKGDYIVFADADDYLPDK
                     EIFCKYINLAEQTDADIVVSNYARLWKDKILPATKHQSFALCSPSSEEFRFQGFFSVGT
                     LSYAWGKLYRREFLRNHQIYFADLSYAEDKLFNMQCYICDAKYAFLEDIGYIYRKNDMS
                     VSWQYRPDSVENWFKLVYELKSWIEKKDKDPKEYTSLIGYLLIFAAFFDGKMEYMQHKK
                     SLWAVRKVLKKYGSNPMGRKAFTELADRRKKLQITQKLWKIMIRTFSLGMKWRWYLLMS
                     VGIKILVSCRVDERLSDTGLRKK"
     CDS             complement(10351..11895)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_13"
                     /sec_met_domain="Polysacc_synt (E-value: 2.2e-14, bitscore:
                     43.4, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQKSRTEYSVMNTTVAFLAQTLAIFMGFFTRVVFTRTLSEGYVG
                     INGLFTDILNILSLSELGVGTAITYALYAPIARRDIKKQQILMRMFRNFYRITAGFVLL
                     AGLCLIPFLDILMKDHPDVNHLIIIYLLYLLNSVVSYLLIYKKTLVDAHQMNYITVMYH
                     NGFLVLQDILQIIVLFLTRNFILFLVIAVVCTIIGNICMSRKADRLFPYLKEPCKEQLP
                     QEERHDILRNVKAMLMHKIGNVVVNNTDNLLISSFVGIISAGIYSNYYLIIGSVRQVLE
                     QAMLGVAASVGNLGVTEENEKIGRIFDSLFFIGYWLFGFAGVCLLELLNPFVKLAFGKK
                     YLFPKEIVLILCINFFINGMRRAVLIFKESMGLFWNDRYKAIAEAVLNLVISILLVTYF
                     GVAGVFAGTFCSTVLTSVWVEPYVIYKYRLKKPVTAFFVKYAGYLGVMAAVWGITEYFC
                     RFISGQAFMILVCRLGICLIVPNILLWFAYRRTAEWKVLWNLLKKIVEKVFTGDKR"
     CDS             11982..12104
                     /locus_tag="ctg9_14"
                     /transl_table=11
                     /translation="MKKKSSIILHSLFFVICSVLAVLCLYHIISIRRLNVKYTPA"
ORIGIN
        1 tattttcaaa tgccagcacc acactactcc aggcaaggct cttacttttc tctctccggt
       61 ctatcagcag ctctctgtta tactctccat ttttaccaat ctttaattta tattggaacg
      121 gtaatcctgt tgccgtttta aataatattc ttctggacac tctcccttta aattttgttt
      181 tgatttattt tctttatccg cttttttcac tgaacaggcc attattaatg gcaacatatt
      241 aatataatgt cgtaataaag tttctgactc aaaacattca ttttgatttt cctctatgta
      301 tataaattcc aacatctcgt atggcaatat acctacactc aaaattttca aatctttcgg
      361 aatttcatat tttgaaaaat ataaattact aatatcttca ggttgcccta attccatata
      421 acaagtatag gttgttcctc ctaaatcttc tatcaattta gcaaatgatt tcactatact
      481 aaaccaatta gctccttttt ggtatacatg tttagttgtg cttcatttga gaaatcaata
      541 atttcaactg aaacattctc tgtatccatt ttgcaaatac cacgagttac accaccgtta
      601 tcagataatg tattcttcaa tacaaatcca gccatgcagg acttgccgcc attcaccaga
      661 tattcatgaa ccgctttaaa tccttctttt ccatccttca tacccatttg gattcttctt
      721 ctgccatctc caagaatctt cacacatttc ttttataccg ttttctgctt tccagtctaa
      781 ttcttttgct gcctttcctg gatcgcagta gcatgtagca atatcaccgg gacggcgatc
      841 ttttataaca tatggaactt tcatacctgt agcagcttca aaattcttta caatatctaa
      901 tacactatat ccttttccgg ttcctaagtt atatatttta aaaccacatt tttcatctat
      961 tttctgaagg gctttcacat gaccttttgc gaggtcaact acatgaatat agtcacgtac
     1021 tcctgttcca tctggtgtat catagtcgtt tccgaatact cccaattctt ttaacttgcc
     1081 tactgctacc tgtgttacgt atggcattaa attgttaggg attccatttg gattctctcc
     1141 catgagaccg cttttatggg ctccaattgg gttaaagtaa cgaagtagaa ttatattcca
     1201 agtttcatct gccttatata tatccataag gatctgctct agcatagatt tagaccagcc
     1261 ataaggattt gtacatagac cttttggaca ttcttctgtg atcggtacaa atgcaggatc
     1321 accatatacg gttgctgaag atgagaaaat aatatttttt acattgtatt ctctcaattt
     1381 ctgtaaaagg attaatgttc cagcaatatt gttctggtaa tactctaatg gttttgcgac
     1441 agattctcct acggacttca atcctgcaaa atgaatacat gattcaatat tttctttttt
     1501 gaaaatggta tctaaaataa ctatatctga aatatcacct ttataaaact ttacttcttt
     1561 ccctgttatt ctttttactc gatttaatgc ttcttcgctg gaattactca aattatcaag
     1621 aacaacaact tccttattat tttctaataa ctctacacaa gtatgacttc cgatatatcc
     1681 tgctccacct gttactaata ctgccatgat attttcctcc gaattatgtc actatgtctt
     1741 tttcgtgttt ttataataat aaatgctttc ttcatcttct acaaaatgaa aaaatattat
     1801 ctagttgcct cttttttatt aataatcgaa accacttcat ctacatatgt atgacagatt
     1861 tcttttgttt ctgcctctac cataacacga atcaatggtt ctgttccaga ctcccgaaca
     1921 agaattcttc cggtatctcc taatctttct gctacttttg atatcgcagc ctgcacatct
     1981 gcatctgcct gcgctacagc tttatctttt accattacat tcacaagaat ctgtgggtaa
     2041 atatgtaaat cctctgtgag ctgactcagc tttttctttt tagccatcat aacttccatc
     2101 atcttcaagc tggtaagaat tccatccccc gttgatgcat actttgaaaa tatgatatga
     2161 ccggactgtt ctcctccgat acggcatccg ttcttcgtca tatattcata aacatattta
     2221 tctccaactg ctgtcttggc atatccaatt cccaactcat caaaagcttt ataaagtcca
     2281 aaattcgaca tgactgtcgt tacaactgta ttggtaagca gcttacctct ttctttcata
     2341 tattttccgt agatataaag aatggcatct ccatctacta catttccctt ttcatctacg
     2401 cagaggcagc ggtctgcatc tccatcatag gcaaatccaa catctaatcc attctctact
     2461 acatacttct gcaatccttc aatgtgtgtc gaacctgcat ctctgttaat attcgtacca
     2521 tctggctctg cattaataac aaatgtcttt gctccaagac tgtcaaaaat ctgttgtgcc
     2581 atgttccagg aactaccatt ggcacaatcc agtccaacct tcattccttt aaaagaatat
     2641 aaaccaagtg aaataaggta tcccatatag cggttacgac ctgctgcgta atccactgta
     2701 catccgatgg catccttatg tgcaaaagga atctcttcat acttctgacc aaatacttcc
     2761 aactcgctat caagataagc ttctacaaga ttaattgtag cttcatccat cttttctcca
     2821 ttgccattaa tcagcttgat accattatca tagtatggat tatggctggc agaaatcata
     2881 ataccacaat caaaatcttc tgttcttgct acataagcca cagaaggagt tgttgttaca
     2941 tgcaaaagat acgcatctgc acctgaggct gtaagcccgg caaccaacgc atactcaaac
     3001 atatagcttg aacggcgtgt atccttaccg atgacaacct ttgccggtat atcatcccct
     3061 ctctgtttct ttaactgacc ataataccag cctaaaaagc ggcctacctt acgtgcgtgg
     3121 tctactgtca aatttacatt cgcttcaccg cgaaaaccgt ctgttccaaa gtattttccc
     3181 atcttttcct ccaagtattt ttaatatatc tttaattcac ttcctaatgg gtaccgaagg
     3241 attcgaacct tcgcttttcc ccttcatata ttatatcaca acacttcttt tttcaattca
     3301 ttccaaatgt tcattttaaa attcctagct tattttagaa actctgcttg atactcttat
     3361 tttcaattat tcttatttat cttgtatatc acattgtttt gaatatacaa catatctacc
     3421 ccgttctcta ctaaatattg catcatgcct cttatatact tttgtacatc aattggaaat
     3481 agcttgtatt tcttccctcc tcagtgttat aatttgctat agtcacagac atcacaacac
     3541 atatataagt ttacaagatt tgtctttgaa aaagaaagga atctttttta tcatgttcaa
     3601 atgtcagccc ggatatacac ttcgaaaaat caaaggtatc agttatctct taccttatgg
     3661 tcagcagatt gccgatctga aaaaaggctt tgtgctgaat gagaccagta ctttcctgtg
     3721 gaatgtactt cagcatcatg aaggtgccga accgcagcaa ctggcagaaa tacttgccag
     3781 gacttatcaa ctggatgagt cttattatcc tgaacttctg aaagatgtga cagattttct
     3841 gacacagctt acagccatgg gaatgatcac agaagatctc cacctgattt catcaatccc
     3901 ttctgtctct atgataatcg caggaatctg cataaaacta tacggttctg cagaactgat
     3961 ttccccaaat tttaaacctt tttatcataa attttcggat gatgatacct cacaggaaat
     4021 cgaactggtc accacgcctc cgcccagccg ttgttacgga caggttcttc tgcagaaatg
     4081 actgtttttg aaaatcccga ccgttatgtt gtcctttttc cacagatgca gaacctttac
     4141 gaagctcata tgctgaaaga tggtacttat gtacgggttt actgccaccc acaggtttct
     4201 gaaacaaata tagaaaattt atttcacgcc atacggctgt ttttcctttt cacagcacaa
     4261 agaaacggac tgtttgcaat ccactcagct tctgttctct atcagggaaa agcatggctg
     4321 ttttccggtc attccggaat gggaaaatcc acacacaccg ctctgtggca tgagcttttt
     4381 gacacaccgt atttaaacgg agacctgaat cttcttggat taaaggagga tcatatcatc
     4441 gtctatggca tcccctggtg cggaacttcc gggattttta ttgctgaagc atatgaactc
     4501 ggaggaattg tcctccttgg gcgcgacctg cagacagatt atctggaaga gttaaatcct
     4561 tcggaaaaag tcctccgtgt catgcagcgc atgatctccc ctgcatggac tgaacgccag
     4621 ctttcagaaa atcttttctt tgccggggaa atcgctgacc gcgtgccggt actacatctt
     4681 ctctgtacaa agaatgcttc tgccgcctgc gtgatgaaaa atgccattga tcaactggag
     4741 gagctgcaat gaaagaaaaa atactcctga tctggaagca cctgaaacag ggaaccctga
     4801 aaaaaatgtg gaaacagaca ttatggatct atcagtacgg cagacgttac tggaaagcca
     4861 tgatcctgta tacactgctt ggtctggtcg gaacaggtgt ctctctggtt tccagtctga
     4921 tttccagaga tctggtagat attattaccg gacaccagac cggaaaactt ataagtacct
     4981 ttgccgcaat gatcggcttc tctgtcgcaa acattctggt ttcgcaggca tccggatatg
     5041 cctctacttt cattaacctg aaggtggact ccgaaatcaa gaacgacatc tttgccaaaa
     5101 tgctggtaac tgactgggaa tccctgaccg attaccacac cggagatctg gtgacacgct
     5161 ggagttccga tgcctccaat atttcaagcg gaatcctgaa ctggattccc aacctgatca
     5221 tttatacttt tcgttttatc agtgcactgg caatcgtgct ttattatgac cctactttcg
     5281 cactttttgc tctgcttgga attcccttca gtgctctgct ttcaaagccg ctgctgaaac
     5341 gaatgcgtga taacaatcag agaagtgcgg ctatgaatgc aaagctttat ggatttaacc
     5401 aggaagcttt ctccaatatc cagacgatca aggctttcga cctgattcac ttttatacag
     5461 agaaactgaa atctcttcag aaagattatg ttaacatgag actggacttc cagaagatgt
     5521 ccattctgac ttctgttctc atgtccatta tcggatttat cgtatcctac agctgttatg
     5581 gatggggaat ttaccgtgta tggagcaatg cgatcagtta cggaactatg accatgtttc
     5641 tgtctttgtc cggtacattg acaagttcgg taaattctct ggtaagtctg attccggcag
     5701 ccatctcact gactatttcg gcaggaagac tgatggatat cgtggaaatg ccgcaggagg
     5761 actacagtca ggattctgct gtacgcaact tcgaaaagca gcataagtca gaaggaatcg
     5821 gtctgaacat gcaggatctc agttatacct atcataatgg tactgctgtt ttcgccaatg
     5881 cttccataga ggcttatcct catgagatcg tggctctggt aggaccttcc ggtgaaggta
     5941 agacaactat gctgcgcctg atcctgtctc ttctgacacc gcaggagggt tcttctcata
     6001 tatgtgccgg aacagatcat gaacacatga ttgatatgtc cccttctaca aggaagttat
     6061 tctcctatgt gccacaggga aatacaatgt tttcaggaac aattgcagaa aatatgcgaa
     6121 atgtgaaaca ggatgctaca gatgaagaaa ttattgaggc gctgaaactt gcctgcgcat
     6181 gggattttgt ggaaaaactc ccggatggaa ttgaaagcat cgttaaggaa cggggcggcg
     6241 gtttctccga aggtcaggca cagaggctct ccattgccag agcattactg cgcagatcac
     6301 cgatcctgct gctggatgag gctacttccg cactggatgt agctactgag cgaaaagtcc
     6361 tgcgaaatat catgcaggat acctacccca gaacctgcat tgtaaccaca cacaggccta
     6421 cggttctgaa tatctgtaac agggtttatg cgatacggga taagaaatgt gagatactaa
     6481 atgacgtgga aattcatgaa atgatacaaa cgttttaaaa tcaatttcag ggattgagtt
     6541 aaacactcta actcaatccc ttttcttgtc aggtggatat tctctttagt tcacagaata
     6601 agtaaatcct gtcatcttaa gatcatcaat acttgctcca tgatctatat gcactccaat
     6661 agtcagcgga ttggatgctg tacttgcaaa tgtcagtgtt gcagtcttac ctgaccagga
     6721 ttcctgtaca gaagcatcat ctgtctcaac ctgatctaat gtatcattaa aagtgatatt
     6781 taaagtaatt gttccattaa tacctgacca gtctgccatt gccagaccct tgccaccatt
     6841 agttccccat ctgtcccata ctccatgata tgttacattt aatgttccct ggcttgcacc
     6901 acttgctgca taaacaccct ctgccattcc tgcgtcaaca gttactaccg gcttcttata
     6961 tgatttcata attaatcatc ctttcctgaa atatgacctt tacattggtt ttatcttttt
     7021 ttatcttatc tatatcccct cagaaagtca agtattctta cacaaaacat actgattttt
     7081 tattttatta cgacaggaaa acactttctg ttgtcctttt gttttcttaa tgttataata
     7141 cgcctgttca gaactttatt tctgaacagg cgtattataa caggaataag gacagatact
     7201 atgaataacc caacatcaga cccagttaaa atcgatctgg aacagcttct ccgggaggga
     7261 aatattatcc gcatcaagcc tcagggttac agtatgtacc ctctcttcat tcccggacgg
     7321 gatgaagcac tgatccaaca gacagacggc acagactgcc acaggaatga tgtagtcctc
     7381 tacaggcgtg atcagggcat cctcgtgctt caccgcatct gccggataac atctgacggc
     7441 ttttatatgg tgggtgacaa ccaatacgaa gtggaaggtc ctctgcgtca ggatcagatt
     7501 gtcggaaaac tgattgctgt aaatcgtaac agcagagaat ttactgtagg aaatcctttc
     7561 tacaaatttg tttcttccct gtggcttttt atgctgcccg ttcgcccatt ctgttttaaa
     7621 ctgtcagcat ttctcagaaa gcttcatcac tcatgatcat ccatttttca taggagaatt
     7681 ccctttttct gcaaagtcag gactacattc cttacatctt caaggacctc tgcaagttct
     7741 atctcatact cttctgctac cagctgtgcc agctcatcga cattctttgc ccgttccgcg
     7801 tgcatataaa taaagcctgc cgtttcgctc aatgagatca cctcattgac ttcttctgtt
     7861 cttcttcctg acggaagtac gagatattca tcctccattc tcctgactac ataaccttct
     7921 gtctttttca ttttcccttt ttctcttcct tttcctttat tttcacgcaa taacatgata
     7981 tacttactat tatttattac tgccattcaa tctctgaacg gtaccaattt tacgcacttt
     8041 cgggagactc ctatggaacg aatatacaat acctatctga aaataataag aaatatctgc
     8101 accggttctg atcattctgt ttccgtacat ccggaagacc ttgcggctct ggcaaagctg
     8161 gcacaggaac attgtactgt cccatttgta ctgccatatc tccggtctgc ttctgtctat
     8221 cctgccatga agcagcaggt aaaaggcatg atgctgaatt attatcagat tgagcatttc
     8281 acccggctta ctgtctctct tttaaaaaag aacaatattg actgttatct tctgaagggt
     8341 ctgagtctgg ctgactgcta tccggttcct gaatatcgta agcttggaga tcttgatctg
     8401 tatctggctg atccttctga cctcgccaga gcgcaggcaa ttcttgaaag caacggatat
     8461 atctctgagg atgaactcag tgaccaccat gtaacctacc gttatatatt tcccaaaacc
     8521 gggcgccgtt ttctcctgga gcttcactat cgtgtagttg gccagtacca gtacagcccc
     8581 gccaacaaac ttgtggattc tgtcttctca ccggaatgtc tgaaggcatc cacccagaca
     8641 atccacggat atacttacac agtcctgccg cctacagaat atactttcta tatgattcat
     8701 catatgctga agcattatct gtacagcgga ttcggtatcc gccttctctg tgattttacc
     8761 ttttatctga agcgtcatga aaaagaaatc aatttccggc agattcatga atggtgcaga
     8821 gaatcccgca tcagccatct gtacgaaatc attctggaat gctgcaggaa atatctgggt
     8881 cttccggatt ctatagatgc ccggacacag tacaatccac acgactgcca tgattttata
     8941 atacagattc ttaaagacgg cgatatggga accgatattt cccagtcact ggttggaagc
     9001 agttcgtatc agaaggttaa cttccttact tatttcaaag aaggacacat ccagatgaag
     9061 gtccgctttc caaaagccag ccattatcca gtcctctggc ctgcactctg gtgtatcaca
     9121 tttatctgtt ttatccgcaa cacttacaca gtacgaaata caacattccg gcagactctt
     9181 catgacttta agaaaaataa tcagaagact aaactgatcc ggatttttga aaacagtgac
     9241 ttctgaccag gagccactgt ctttactttt tccttagtcc agtatcagaa agtctttcat
     9301 ctacccggca ggaaaccaaa atctttattc ccacagacat caacagatac cacctccatt
     9361 tcattcccaa cgaaaatgtc cggatcataa tcttccacaa tttttgcgtg atctgcagtt
     9421 ttttccttct gtctgccaac tctgtaaaag cctttctccc catcggattg cttccatatt
     9481 tcttaagaac ctttctgaca gcccacagag attttttatg ctgcatatat tccatttttc
     9541 cgtcaaaaaa tgccgcaaaa ataagcaaat atccaatcag tgaagtatat tctttcggat
     9601 ccttgtcttt tttctctatc cagcttttca gttcatatac aagtttgaac cagttttcta
     9661 cagaatccgg acgatactgc caggaaactg acatatcatt ttttctgtaa atatacccta
     9721 tatcttccag aaatgcatac ttcgcatcac agatataaca ttgcatatta aacagtttat
     9781 cttctgcata agaaagatcc gcaaaataaa tctgatgatt tctcagaaac tctcttctgt
     9841 ataatttccc ccacgcataa gaaagtgttc ctactgagaa aaatccctga aatctgaatt
     9901 cttcagatga tggactacat aatgcaaatg attgatgttt agtagccggc aatattttat
     9961 ctttccacaa tcttgcataa ttgctgacaa caatatccgc atctgtctgc tctgcaagat
    10021 ttatatattt acagaatatc tccttatcag gaagataatc atctgcatcg gcaaacacaa
    10081 tgtagtcacc cttcgcaatc ttcagccctc tgtttcttga agctcctgga ccctttcccg
    10141 atccttcaat catatggatc tccgggtatt ttgcttcata tttctgtata atatcaggac
    10201 ttctatcctt tgatccatta tctatcaata taatttccag agttttataa ctctgcttta
    10261 taatactgtc cagagtttct ctgatgtact tttctgcatt gtatacaggt ataatcacag
    10321 aaatcttttt ctgctgtttt tccaaagctg tcatctttta tctcctgtaa aaactttttc
    10381 tacaattttt ttcagtaaat tccataatac tttccactct gcagttctcc tgtaggcaaa
    10441 ccacaataaa atattcggca caatcaggca gattcccagt ctgcatacca gaatcataaa
    10501 tgcctgtccg gaaataaatc tgcaaaaata ttccgttatt ccccatactg cagccatcac
    10561 ccccagatat cctgcatatt ttacaaagaa agcggtaaca ggctttttca gtctgtattt
    10621 ataaatcaca tagggttcta cccatacaga agtaagtact gtactgcaga atgtacctgc
    10681 aaatactcct gccacaccaa aatatgtaac cagcagaatg gaaattacca gatttaacac
    10741 tgcttcagct atcgctttgt accgatcatt ccagaacagt cccatagatt ccttaaaaat
    10801 cagcactgca cgtctcatcc cattaataaa aaaattaata cacagtatca aaacaatttc
    10861 ctttggaaat aaatattttt taccaaatgc cagcttcaca aaaggattca gcagttccag
    10921 caaacagaca cctgcaaaac caaacagcca gtaccctata aaaaacagac tgtcaaaaat
    10981 ccgtcctatc ttttcgttct cttccgtcac accaagattt cccacacttg ccgcaactcc
    11041 cagcattgcc tgctccagaa cctgcctgac tgatcctatg atcagataat aattggaata
    11101 aatccctgca ctgataattc ccacaaaact tgagatcagc agattatctg tattatttac
    11161 tactacatta ccaattttat gcatcagcat tgcctttaca ttccttaaaa tatcatgacg
    11221 ttcttcctgt ggaagctgct ccttacacgg ttctttcaga tatgggaaca gcctgtctgc
    11281 ctttcgggac atacagatat ttccgattat ggtacataca accgcaataa caagaaacag
    11341 gataaagttt cgtgtcaaaa acaatactat aatctgaagg atatcctgca gtacaagaaa
    11401 accattatga tacatcaccg taatataatt catctgatgg gcatctacca gtgttttttt
    11461 ataaatcaat aaatacgaaa caacggaatt aagcagatac agaagataaa ttataatcag
    11521 atgattcaca tctggatgat ccttcatcaa aatatccaga aatggtatca ggcataaacc
    11581 ggcaagcaga acaaagcccg ctgttatcct gtagaaattc cgaaacatcc gcatcaggat
    11641 ctgttgtttt tttatatctc ttctggctat aggagcgtaa agagcatatg tgattgctgt
    11701 tccgacccca agttctgaca aagacaatat atttaatata tctgtaaaca aaccattaat
    11761 tcctacataa ccttcactga gagtcctggt aaaaacaact cttgtaaaaa aacccataaa
    11821 aattgccaat gtctgtgcca aaaaagcgac tgtcgtattc ataacagaat attctgtcct
    11881 tgatttctgt ttcaatcttc acttatcctt tctttttggt tataatacat tatagtcaat
    11941 tcatagttat atgtatagat atttttaagg agcaaatatt catgaaaaaa aaatcatcaa
    12001 tcatcctgca cagtcttttt tttgttatct gctcggtgct ggctgtatta tgtctctacc
    12061 acataatctc catcagacgg ctaaatgtaa aatacactcc tgca
//
