LOCUS       c00006_gnlPro..        16301 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ELBIODCO_6.
ACCESSION   c00006_gnlPro..
VERSION     c00006_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 18:42:07
            Original ID  :: gnl|Prokka|ELBIODCO_6
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16301
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16301
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2749:6301](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2750..6301
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16301
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16301
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(177..1391)
                     /locus_tag="ctg6_1"
                     /transl_table=11
                     /translation="LNSFKMTKKALYIFNPEHDLALASGETNYMAPASARQMASELALL
                     PMWYAEEGSVVLAPSAYNLDYVKKIQELLGLSVDLMTEPELVSERNLEIRPWGWDIAIR
                     KQLLDLGVEESELPSIEQLDKLRFCSHRSCAVGLLPQLQLGACFCGESFYLTFPEEWKS
                     FVESHDTCLLKAPLSGSGKGLNWCKGVYTPSISGWCSRIGKQQGGVIGEPLYNKVEDFA
                     MEFRSSSNGRFGFAGYSQFRTGGSGAYEGNLLISDAAIERNLLEYIPVEEIYKLRDRLE
                     QELSLRFGTIYNGYLGVDMMICRFPESPVYRIHPCVEINLRMNMGVVARHIYDHYIYPT
                     STGAFQISYYPTEGTAWRAHKEMEEAYPLEIEQGRIKSGYLSLVPAHKKSSYRAWVFIS
                     KSVFL"
     CDS             1539..2717
                     /locus_tag="ctg6_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     RELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREYLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFANSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2750..6301
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_3"
                     /sec_met_domain="PFOR_II (E-value: 4.4e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 5.1e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 5.1e-31, bitscore: 100.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-11, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 1.8e-11, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 2.8e-08, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00014, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 8.6e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNEILAADNASPEAKEVLKAWIENMYDADKTKE
                     LAPQVKAVIEEGLSHGCPICKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAK
                     WRYNSYKRLARENWGAE"
     CDS             complement(6454..7320)
                     /locus_tag="ctg6_4"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFFG
                     EVYGEARVGLVVPQYVTIHSINELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVDSW
                     IPKSENK"
     CDS             complement(7341..8165)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.5; E-value: 8.7e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg6_5"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.1e-28, bitscore:
                     92.5, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMVHFSTFFDAVNAGIGSFIIGFQHILFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSPRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8162..9388)
                     /locus_tag="ctg6_6"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTAGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDTDDKLVGEVRLNDLLKLRSKQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETREFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(9688..10026)
                     /locus_tag="ctg6_7"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMPQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10110..11498
                     /locus_tag="ctg6_8"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLFGV
                     FAFSSCEKNLYDESKQPEKEIQVKDLDIPAGFQWKLTQVAAGTVAATTPTMVSFFLDEA
                     CSKEEKIADIPVDTEISSLPLSIPTYVNTLYAQYKTSTNETKKVTIPVNADRSFSLNIT
                     NDAKSKSNTTRSITRGHDIEDDIQLAKGVIFHPKDGWGTIMFEDQFPSLGDYDFNDFVV
                     NYKVQFQGIKKVDKKYTAQYIQIGLRLKAIGGIFPYSPYLRLKEIDSDEVESIEVYETK
                     NVIPAIDGVDLVPNKHLIIDYSPLIKNLAKPAGSQYYNTEKNALVATSDLPEINILITL
                     KKRKEVKEILEGDEFDLYLKRNDSGTEIHMNGIEPITYQYPFNDKNLLPVYTNGDEEDD
                     NYYFSAGRLIWGLRVPGNAAHAIEKANFLEAYKGFAKWAQSSGKNEQNWYNQGNADKSL
                     LIHN"
     CDS             complement(11579..14416)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 61.6; E-value: 2.6e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_9"
                     /sec_met_domain="Peripla_BP_1 (E-value: 3.4e-19, bitscore:
                     61.6, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRMMGYTKWIAVLLCLLGMTACRQDTHRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDEGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNFPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRI
                     APGAYQAAKKVGREKEMIFVGIDALPGKGNGLEMVLDSVLNATFIYPTNGDKVMQLAMN
                     ILEKKPYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRAKNRLNKELSEQKKQLEEQRDKLEEQRDQLEEQRD
                     KLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADHTLSGDQH
                     RMLMLIQRNVNILLRLVNQILDFRKYENGKMEYTPVQVDVLSSFEGWNESFLAAARKKH
                     IHFSFDNMPDTDYHTLADMEKLERIYFNLLSNAFKFTPENGKITVRLSSLTKEDTRWIR
                     FTVANTGSMISAEHIRSIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTISVESDEKQG
                     TVFTVDLPVQTCETILAEDSLKSSISAVPLNPASPGSPASSDLNGTLAAEEEELEKGYD
                     SSKPSVLVIDDNADIRSYVRGLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPGI
                     DGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVRN
                     LIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGDSNLNVEDLGKDMGLS
                     RVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFTKCYR
                     EQFGESPTDLLKRKG"
     CDS             complement(14806..15924)
                     /locus_tag="ctg6_10"
                     /transl_table=11
                     /translation="MKHVSILFRSKCWNVFLLLCIALPSLAQKEFKIDQVSVVNVGDGR
                     FLYRDLMTEKPLNGEHRIIDGYHSAYILASFKDGFYDGKYEEHLDNILINEGVYKDGRK
                     NGLFKIYSKFDGKLKEEKSYKEGKLNGTSKTFFTDGKIESEKNYRMGKEDGKHLSYDYD
                     GTLRMDHNYKDGKQVGKQYTFMKGTYELYETVYYNNEGLKDGEYSSIFTFGAPHVLGSY
                     KNGQKNGRWTEIAESGDTIVIETYLNGKEEGLHVSYSGETGMRTKEYYLKNDRKDGIYR
                     EYDLKNGELKYEATYQFGRLHGKARQLVVDNRFDYWETSTYVNGRQNGPFESRYVKNNK
                     LRECGEYKNGHRVGRWKLYTIDGKLEREWDEN"
ORIGIN
        1 gtaaacgaac ttaggtataa caagcgaagt tgtcaactaa atccagtaca gtacacacat
       61 ggcatgtgat tacttgtttc atgcaatgaa actttttgtt tctcggtgtg gaaccaatgg
      121 tttcactaca tgaaactatc agtttcacac cgagaaacca taacttcgat ataatatcac
      181 aaaaacacgc tttttgagat aaacacccac gcccgataac tactcttttt atgagccggc
      241 accaatgaca aatagcctga ttttattctt ccttgttcta tttccaaagg ataagcctcc
      301 tccatttctt tgtgtgctct ccaggctgtt ccttccgtag ggtaatagct tatttgaaaa
      361 gctcctgttg aagtaggata gatataatgg tcataaatat gacgcgctac tactcccata
      421 ttcatcctca agttgatttc cacgcaagga tgaatccgat aaacaggaga ttccggaaag
      481 cgacagatca tcatatccac tcccaaataa ccattataaa tggttccgaa acggagggat
      541 aattcttgtt caaggcggtc gcgcaattta taaatttctt cgacagggat atattccaaa
      601 agattccgtt cgatggctgc atctgaaatc agcagattac cttcgtacgc cccacttcca
      661 cccgtacgga attgagagta tccggcaaag ccaaatcgac cattactcga agaacgaaat
      721 tccatagcaa aatcttccac cttattatat agaggttcgc caataacacc tccttgctgt
      781 ttgccaatgc gtgagcacca accggaaatg gaaggagtat atacaccttt gcaccaattc
      841 aacccttttc cgctaccgga taaaggagct ttcagtaaac aagtatcatg tgattctaca
      901 aatgacttcc attcttcggg aaacgtcagg taaaaagact ctccacaaaa acaggctccc
      961 agttgtagct gtggtaataa tcccacagca caggaacgat gggaacagaa acgcagttta
     1021 tccaattgct caatagaagg aagctcgctt tcttccactc ccaaatccaa cagttgtttt
     1081 cttattgcta tatcccagcc ccaaggacga atttccaaat tccgctccga aacaagttca
     1141 ggttctgtca tcaaatcaac cgaaagtcct aataattcct gtatcttctt cacatagtcg
     1201 agattataag cggaaggagc caatacaaca cttccctctt ctgcatacca catcggcaac
     1261 aaagccaatt cggatgccat ctgccgggcg gaagccggtg ccatatagtt tgtttcaccg
     1321 ctggctaacg ccaaatcatg ttccggattg aatatataaa gagccttttt tgtcatttta
     1381 aacgaattca aaactttatt ctgcaaatat atacaggaaa tagtcaggaa tggctacaat
     1441 aaacagaaag ttctaattaa actcacaatt ttgccatctc tactttgcaa atcctaaaaa
     1501 aagcagtata tttgccaccc gaaaaacaaa gaactgaaat ggaatcattc tatcgcacac
     1561 acgcctacct cgttgagcac accaatgccc ccgttcgccg cgatcttatg gacgagatcg
     1621 actggagcga ccgcctgatt ggtatcaaag ggacacgtgg cgtaggaaaa accactttcc
     1681 ttctccaata cgccaaagaa aaatttggga acgaccgctc ctgcctgttc atcaacatga
     1741 acaacttcta cttctctggc cacagcattg tagactttgc taacgaattc cagaaacgtg
     1801 gtggaaaagt attgttgatc gaccaagtgt tcaaacaccc ggaatggagc agagagttgc
     1861 gcatgtgtta cgaccgtttt cctaatttga aaattgtctt taccggctca tccgtaatgc
     1921 gactgaaaga ggaaaatctt gaattgcgtg atattgcaaa aagctataac ctgcgcggat
     1981 tttctttccg cgaatacctg aacttacaaa caggcatgaa attcagggcc tacagtctcg
     2041 aagaaattct tagcactcac gaacagattg ccaaaggagt actctctaaa gttcgtccgc
     2101 tggattactt ccaggattac ctgcatcatg ggttctatcc attcttcctc gagaagcgta
     2161 acttttcgga gaatttgctg aaaacgatga acatgatggt ggaagtagat atcctgctca
     2221 tcaaacaaat tgaactgaaa tatctttcaa agataaaaaa attactatat ttgctcgctg
     2281 tcgacggacc gaaagctccc aatgtgagtc aactggcaag tgacatacag acatctcgcg
     2341 ccacggtgat gaactatatc aagtatctgg cagatgcgcg actcattaat ctggtttatc
     2401 cgaaaggaga agaatttcct aaaaaacctt ccaagataat gatgcacaac tccaacctga
     2461 tgtattccat ctatcccgtg aaagtggagg agcaggatgt actcgacaca ttctttgcaa
     2521 attctttatg gaaagaccat aaggtacata aaggagataa aaacgtctct tttatggtgg
     2581 acgaagtaat gccgttcaaa atttgccagg aaggagcaaa gatcaagaac aatccgaatg
     2641 tgacgtacgc gttgcataag gctgaaatag gtcggggcaa ccagatacct ctctggatgt
     2701 tcggcttttt atattaaaag atttatttac ttaaatattt aatttagtta tgactaaaca
     2761 gaagaaattc atcacttgtg atggtaacca ggctgcagcg catatctcgt atatgttctc
     2821 tgaagtagct gctatctacc ccatcactcc ttcttcgact atggctgagt acgtagacga
     2881 atgggctgcc gcaggacgta agaacatctt cggcgaaaca gtattggtac aggaaatgca
     2941 atctgaaggt ggtgctgccg gtgcagttca cggttctctt caggctggtg cgttgactac
     3001 tacttacact gcttctcagg ggcttctcct gatgatccct aatatgtaca aaattgccgg
     3061 tgagttcttg ccttgcgtat tccatgtatc tgctcgtaca ttggcttctc acgcattgtg
     3121 tatcttcggt gaccaccaag acgtaatgtc agctcgtcag actggctttg cgatgttggc
     3181 tgaaggctct gtacaggaag ttatggattt ggctggtgtt gctcacttgg ctaccatcaa
     3241 atctcgcgtt ccgttcatga acttcttcga tggtttccgt acatctcacg aaatccagaa
     3301 gattgaaatg ttggaaaatg atgatcttgc tccgctgatc gatcaggaag ctttggctga
     3361 attccgtgcc cgcgcactga atccgatgaa tccggttgct cgtggtatgg ctgaaaaccc
     3421 cgaccacttc ttccaacatc gtgaatcatg taacaactac tatgaagcag ttcctgctat
     3481 cgtagaagaa tacatgaatg aaatttctaa gattacaggt cgtaaatacg gtttgttcga
     3541 ttattatggt gcagaagatg cagaacgcgt aattatcgct atgggttctg taacagaagc
     3601 tgcccgcgaa gctatcgacc acttggtagc aaatggcgaa aaagtgggta tggttgccgt
     3661 acacctgtat cgtccgttct ctgctaaaca cttcctggct gctgtaccta agactgccaa
     3721 gactatcgca gttcttgacc gtactaaaga accgggcgct aacggcgaac ctctttacct
     3781 tgacgttaaa gactgcttct acggcgcaga aaatgctccg gttatcgttg gcggtcgcta
     3841 cggtttgggt tcaaaagata ctactcctgc tcaaattctt tcagtattcg aaaacttggc
     3901 catgccaatg ccgaagaatc acttcactat cggtatcgta gacgacgtta ctttcacttc
     3961 tcttcctcaa aaagaagaaa tcgctttagg cggtgaagga atgttcgaag ctaaattcta
     4021 cggtttgggt gctgacggta cagtaggtgc taacaagaac tctgtaaaga ttatcggtga
     4081 caacactgac aaacactgcc aggcttactt ctcttatgac tctaagaagt caggtggttt
     4141 cacttgttct cacttgcgtt tcggtgatac tccgatccgt tccacttatt tggtaaatac
     4201 tccgaacttc gttgcttgtc acgttcaggc ttacctgcac atgtacgatg taactcgtgg
     4261 tttgcgtaag aacggttctt tcttgctgaa cactatctgg gaaggtgaag aactggctaa
     4321 gaacctgcct aacaaggtta agaaatattt tgcacagaac aacatttccg tatactatat
     4381 caacgcaaca cagattgcat tggaaattgg tttgggtaat cgtaccaaca ctatccttca
     4441 atctgcattc ttccgtatca caggtgttat tcctgtagac caggctgttg aacagatgaa
     4501 gaaattcatc gttaagtctt acggtaagaa gggtgaagac gttgttaaca agaactatgc
     4561 tgccgttgac cgtggtggtg aatacaagac tttagctgtt gatcctgctt gggctaacct
     4621 gccggatgat gcaaaagctg aaaacaacga tcctgcattc atcaacgaag tagttcgtcc
     4681 gatcaatgca caagatggtg acttgctgcc tgtatctgca ttcaagggta tcgaagacgg
     4741 tacttggtat caaggtactt ctaaatacga aaaacgtggt gtagccgcat tcgttcctga
     4801 atggaatcca gaaaactgta tccagtgtaa caagtgtgca tacgtttgtc ctcacgcttc
     4861 tatccgtccg ttcgtactcg atgctgaaga gcagaagggt gctaagttcg aacaattgaa
     4921 agcagtaggt aaagtattcg acggtatgac attccgtatc caggttgacg ttctcgactg
     4981 tctgggttgc ggtaactgtg ctgacatctg tccgggtaat ccgaagaagg gtggcaaagc
     5041 attgacaatg aaacacctcg aaagccaatt ggctgaagct gacaactgga cttactgtgc
     5101 tgaaaacgtg aagactaaac aacatcttgt tgatatcaag tctaacgtga agaactcaca
     5161 gttcgctact ccgttgtttg agttctctgg tgcttgctct ggttgtggtg aaactccgta
     5221 tgtgaaattg atttctcaat tgttcggtga ccgtgaaatg gttgctaacg ctaccggatg
     5281 ttcttctatc tactctggtt cagttccttc tactccgtat actacgaacg aaaacggtca
     5341 cggtcctgct tgggctaact cactgttcga agacttctgt gaattcggtt tgggtatgga
     5401 attggctaac gaaaagatgc gtgctcgtat cgtgaagtta ttcaacgaaa tccttgctgc
     5461 cgacaacgct tcacctgaag caaaagaagt gctgaaagca tggattgaaa acatgtacga
     5521 tgctgacaag actaaagaat tggctcctca agtgaaagca gtgattgaag aaggtctttc
     5581 tcacggatgt cctatttgca aagaactgaa aggactgact caatatcttg taaaacgcag
     5641 ccagtggatc attggtggtg acggtgcttc ttacgatatc ggttatggtg gtcttgacca
     5701 tgtaatcgct tccggtaagg acgttaacat cctcgttctg gatactgaag tttactctaa
     5761 cacaggtggt cagtcttcta aggctactcc ggtaggtgct atcgctaagt tcgctgctgc
     5821 tggtaagcgc gtacgtaaga aagacctcgg tctgatggct actacttacg gttatgtata
     5881 tgttgcacag atcgctatgg gtgctgacca agctcaaact ctgaaagcta tccgtgaagc
     5941 tgaagcatat ccgggaccat ctttgattat cgcttacgct ccatgtatca accacggtct
     6001 gaaagcaggt atgggtaaga gccaggaaga agaagaaaaa gctgttaagt gcggttactg
     6061 gcacttgtgg cgttacaacc cagctttgga agaagaaggc aagaacccat tccaattgga
     6121 tagcaaagaa ccgaactggg aagatttcca aggtttcttg aagggtgaag ttcgttacgc
     6181 ttctgtaatg aaacaatatc ctactgaagc tgaagaactg tttaaagctg ctgaagaaaa
     6241 cgctaaatgg cgttacaaca gctacaaacg tttggctaga gaaaactggg gtgctgaata
     6301 atagtaatac cctataaata taaagcggta atcttatcaa agattaccgc ttttttattg
     6361 tatgaactct gtccaacata aacagtactc cctttttccc actaaagttc atgtctattt
     6421 tatatttaaa attaagaata acaatgctcc aatctattta ttctctgact tcggaatcca
     6481 actatccacc aacagccgat gctcatccct ccatttacgg gctatttctt cttcatccat
     6541 cctggcatcc ttcatagctg tcataaaaga gctaagttct tctgtcgtta gtttgatgtt
     6601 gccaaagaat tcggcagcaa acggatcttt ctcactgaat cctttccatg caatagcatg
     6661 tatttcttcc aagtctccat atactttctt cggatcatcc aagaatttca agtcaaactg
     6721 gtcgaacatc caatgcggtg tccaccccgt aatgacaatc cattctcctt tgtccatcgc
     6781 ttttttcaaa gaagccagca tggtggaact acttgaagtc atgagggtat acccatcaag
     6841 tccgtaagca gcaatggcct tatcggtcgt cttcattatc cctgctcccg catcaattcc
     6901 tactatttca gaagaaaaac ggtctttatt agcttccagc tcattaatag agtggatcgt
     6961 aacatattga ggaacaacca gtccgacgcg agcttctccg tatacctccc caaaaaattc
     7021 gatgctgtct ccatactgat ccatataatc tttcatcgtt attggtaacc aggcatccag
     7081 aaacacatca gatttctttc ctgacataga tacaaagatg ggggcaaggt cagcattttg
     7141 cagttcaacc tcatatccat gctcttccaa taccacctta gccaaatgac tcatggcaat
     7201 accttccagc caattggcat aggctatttt tactttcttt ttctctaagt ctgaattagt
     7261 acaggaagcc agcaaaagca tagctgacaa tactattcct actattttat atattctcat
     7321 acgtatttta tcctttccgt ttagttctta ttttttcgtc ctgccattcc ttgcgtgata
     7381 cggtctaaga tgatagctaa aataacaact gctataccac cttcaaaccc aagtccgatt
     7441 ttcatttggg taataccttt caatacaatt tctcccagac caccggcagc aatcatggca
     7501 gcaattacaa ccatagaaag cgacatcatt attgtctggt tgacaccagt cagaatggtg
     7561 ggcaacgcca aaggaagctg cactttatac aataactgcc aacgggtagc tccgaacgaa
     7621 cgggaagctt ccactacatt tttaggaact tgccggattc ccaatccggt aaggcggacc
     7681 acaggaggca tagcaaagat aatggtggca aacactcctg gcactgctcc caatccgaaa
     7741 aacaaaacag caggaatcag ataaacaaaa gcaggcatcg tctgcatcaa gtcgagaaca
     7801 ggacgaagta ttttctctgc acgcggactg tttgccgtcc acactcctaa aggtacacca
     7861 acaatcagag ccagacaggt agatgaaaaa acgagagcca gggtttgcat agtagcctcc
     7921 caaaatccca ttccatagat cagtaataat cccaatgcgg tgaaaattgc cgtaccgcgt
     7981 cctgctttca tccatgcgag tgcagcaagt accaaaatgg ttatataaaa aggtattccg
     8041 aaaagtatgt gttggaatcc tataataaaa ctaccgatgc ccgcattcac ggcatcaaag
     8101 aaagtggaaa aatgtaccat catccaattg atggccatct ctatatattg tcctatattt
     8161 atcataaatc tattgcgttt tgaattattt cgtttatttc ttctttatct ttcccggtca
     8221 cttcgatgat taaggatgaa agcgggattg ttcctaaaaa ctcgcgcgtc tcatcaatca
     8281 cccataccgg cgaattgctc tttgtcatta gaggaagtat atcctccaac accgtatcct
     8341 ccaacacaga atgtacttct gtacgcacaa tcgtttcaat ggatttttcc tgtttgctac
     8401 gtaacttaag caagtcgttc agacgtactt ctccgaccag tttatcatcg gtgtctatga
     8461 caggtaatac ggtgatattc ttcgcacgca tcttacgaat caatacttcg ggaccttctt
     8521 tcttcagacg ggccaccaac ggtttgtcaa tcattaaaga agaggcggta ataattttgc
     8581 tcctatccac gttttcaaca aaacgggcta cataatcgtt agccggttca gtcaggattt
     8641 cctccgaagt acctacctgc accacttctc cgtctttcat gatggcaata cggtcaccta
     8701 gcttaattgc ttcactcaag tcgtgggtaa taaaaacaat cgtctttttc atctttgatt
     8761 gcaaggccag tagttcatcc tgcatctgta cgcgaatcag aggatcgaga gcagagaaag
     8821 cctcatccat taaaagcact tcaggattat tagccagagc gcgagccagt ccaacacgct
     8881 gttgcattcc accggaaagc tcgcctacca tctgattttc atatcctttc aatccgacaa
     8941 gcttcatgct ttccatcgct ttcttctcac gttcctcttt cttcactccc tgaagttcga
     9001 ggccgaacgc gatattgctc aatacggaac ggtgaggtaa cagaccgaaa ttctggaaaa
     9061 ccatcgccag ctctttccgg cgaacctgca ataattcttt ttcggaaatt ttagatatat
     9121 ctactccgtt tacaagcact tgcccggcag taggacgtat cagacgattg atacaacgca
     9181 gtaatgtcga ttttccactt cccgagagtc ccattatcac gaaaaactct ccttcattaa
     9241 ttgaaagatt ggcatctttc actcctaccg tacaaccggt atctttcaga atttcctctt
     9301 tactcttatc ttttttcaac atcttgaggg ctttctgctt ctcgttacca aagataaggt
     9361 acaaatcctt tatttctatt ttactcatat aatatattgg tttagattat aatatttgtt
     9421 ttgttttcaa ctgccgcatt ccttattctc acttacgata aacaagttga atgttcgcat
     9481 ggttcagtca tgtcacatga taacatgacg gtccgacgtt ttttaaatgg tttaaaaaaa
     9541 acagacagag tagtttaaaa ggaatagaat ttgataagat tatcctctta atgaacagta
     9601 gaaaacagta ttttcataaa taaataacag tctgttcttg catattgttg gcacaaaggt
     9661 aaggaaaata gattaaatat gcaaatttca ttcaggtacg gagtaattcc aaagatgctt
     9721 tttcaagtct acgcatccat tttgtttgaa agagatccct tcttccaaca agagttgttt
     9781 ctgctctgtc caacccggaa caagccgtcc cgacgcattg acaacccgat gacaaggcgc
     9841 agataaatca tccggaatct gcttcaaagc acgccccacc atacgggaac attgaggcat
     9901 tcccaataat gcggcaattc ccccataggt agaaacttta cctaccggaa tttcccgaac
     9961 aacctgatac acctcttgac aaaaggatgc ggaaaggctt gccttatcta ctttataatc
    10021 tttcatcact caaacattac tttatttcag ttccaaaact agataaaaag aaaagaattt
    10081 gcaaataata aaagcatttc aaataaaata tgcaacttta tttgctttat ttacaaataa
    10141 tcccgacctt tgtacccatt aaaagcaacc ctattattaa caaaacaagc actgctgtta
    10201 tgaaaaagaa gacaattcta ttcgcttctt gtttatttgg agtattcgct ttcagctcct
    10261 gtgagaagaa cctttatgat gaaagcaagc aacctgaaaa agaaattcaa gtaaaagacc
    10321 tggatatacc cgcaggcttt caatggaaat taactcaagt agccgcagga acagtagctg
    10381 ctactacccc cactatggtt tccttctttt tggatgaagc atgtagtaaa gaagagaaaa
    10441 tagccgacat tcctgtagat acagaaattt caagtctccc tttgagcatc ccaacctacg
    10501 taaatacatt gtatgcccag tacaaaacca gcaccaatga aacaaaaaaa gtaaccatac
    10561 ctgtaaatgc agatagaagt ttctcactga acattactaa tgatgccaaa tccaaatcta
    10621 acaccacccg gtcaatcact cgtgggcatg atatagaaga tgacatccaa ttggcaaaag
    10681 gagtcatttt tcatcccaaa gatggttggg gaacaatcat gtttgaagac caattcccat
    10741 cattaggaga ttatgacttt aatgattttg tagtcaatta taaggtgcag ttccaaggta
    10801 ttaaaaaggt tgacaaaaaa tacactgcgc agtatataca aataggatta cgtctaaaag
    10861 ctatcggagg aatattccct tattctcctt atttaagact gaaagaaata gattctgacg
    10921 aagtggaaag tatagaagtt tatgaaacta aaaacgtgat tcctgcgatc gacggagtag
    10981 atcttgtccc caataaacat cttatcattg attacagccc tttaattaag aatctggcta
    11041 aacctgcagg cagccaatat tataatacag aaaagaatgc tttggtagca acaagtgatt
    11101 taccggagat caatatcctg atcaccctaa agaagagaaa agaagtaaag gaaatattag
    11161 aaggcgatga attcgacttg tatttaaaac gtaatgatag cggaacagaa atccatatga
    11221 atggtattga accgatcact taccaatatc cattcaatga taaaaatctg ctaccggtat
    11281 atacaaacgg ggacgaagaa gatgataatt attattttag tgcaggacgc ctgatttggg
    11341 gattaagagt accaggcaac gcagcacatg ctattgaaaa agccaatttc ttggaagcct
    11401 ataaaggatt tgcaaaatgg gcgcaaagta gtggcaaaaa cgaacaaaac tggtataatc
    11461 aaggaaacgc agataaaagt ttattgattc ataactaaca catatcaata aatcccggta
    11521 aacattgaaa attcaagtta ccgggattta ttgtattctg acgtgaatag ttttgattct
    11581 atcctttcct tttcagcaaa tctgtcgggc tttcgccaaa ctgctctcta taacatttgg
    11641 taaaataaga aggagagctg aaaccgactt cataaccaat ctctgccact gtcatatccg
    11701 acgaagcaag caaggaagca gctttcttta aacgagcgat acgaagcaat tcattcggag
    11761 aataattagt caaggatttt attttgcgat agagctgcac acgacttaat cccatatcct
    11821 tacccaaatc ttctacattc aaatttgaat ctcccatctt tgcttcaatc aaagccttga
    11881 atttttccac aaagtcttta tccatatcac agacatcctc tttcgccaac gtttgtccgt
    11941 caccaaagaa ctgtttcagg cggcgatgtg aatctatcag attacgaacg cgtgccaaca
    12001 gcaattgcga actgaagggc ttggagatat aagaatccgc acctccgtca tatccctgaa
    12061 tccgttgttc atccaaagaa caggctgtca ataagatgac agggatatgg caggtttgca
    12121 gttcgctttt cagccgacga caacactcta ttccatcaat accaggcatc atcacatcag
    12181 agattatcaa gtccgggaca tatttcattg ctttgcggat gccctccgaa ccgtctgctg
    12241 cttcaattac agtataatcg gtatggagta atccgcgtac atacgaacgg atatctgcat
    12301 tatcatcaat taccaaaacg gaaggcttgg aagaatcata gcctttttcc agttcctctt
    12361 cttcggcagc taaagttcca ttcaggtcgg aagaggcggg agatccggga gaagcaggat
    12421 ttaaaggaac tgcagagatt gatgacttta gagaatcttc ggccagaata gtttcacaag
    12481 tctgtaccgg taaatcaacg gtaaagacag tgccctgctt ttcatcactt tccacagaaa
    12541 ttgtaccttt atgcaattca acgaaagctt tgaccaatgc aagtccgatt cccgaaccgg
    12601 catggtgcat gtctatttta taaaaacgat cgaaaatgct ccggatatgt tcggcggaaa
    12661 tcattgaacc ggtattggct acagtaaaac gaatccaacg agtatcctct ttcgttaagg
    12721 aagataaacg aaccgttatc tttccatttt ccggtgtgaa cttgaacgcg ttggaaagaa
    12781 gattaaaata aatacgttcc aacttttcca tatccgccaa tgtatggtaa tccgtatccg
    12841 gcatattatc aaaagagaaa tgaatgtgtt tcttccgggc cgctgcaagg aatgattcgt
    12901 tccagccctc aaaagaggaa agaacatcta cctgaactgg tgtatattcc atcttaccgt
    12961 tctcgtattt acggaaatcc agaatctgat tgacaagacg taaaaggata ttcacgtttc
    13021 gttgaatcag catcaacatt cgatgctgat ctccacttag tgtatgatcg gccaataaat
    13081 gttctaccgg atcggcaacc aatgtaagcg gagtacggaa atcgtgagat atatttgtga
    13141 agaaaaccag tttggcatgc gttgcctctt ccagttgatg agaaagctgg atgagctgat
    13201 cccgttgttc ttccagttta tcccgctgtt cttctaattg gtcgcgttgt tcctctaact
    13261 tgtcccgctg ctcttccaac tgtttcttct gctcggaaag ttccttattc agacgatttt
    13321 tagcacggag agatttatag actaccaata ataaacctgc caccaataga agaataacca
    13381 aaccaccata catcaccacc tgctgtgtag caacccgaga cagatatccg ccgatacgtc
    13441 cgttcaatgt ttcaatcttc tgatccagtt ccgagatatg agtcgtctga agttgcatga
    13501 catgcgcatt tgtacggtcg accaccgcag tgttcatgac cgtttcccgg ggataaggct
    13561 ttttctcaag gatattcatt gccagttgca tcactttgtc gccattggtc ggataaataa
    13621 aagtagcatt caacacactg tcgagcacca tttccaatcc gttacctttg ccggggagag
    13681 catcgatacc gacaaaaatc atttccttct cccgtcccac tttctttgca gcctgataag
    13741 ctcccggagc aatacggtca ttatgcgcat acacggcgtc tatcttcgga tgccgacgga
    13801 gcatactatc catttccact tccgccggtt cacgctccca cgcagcatcc gctttatcaa
    13861 tcagtttgat atccggaaag ttactgatag cagccataaa tccttgatgg cgttccatgg
    13921 caggagttga gccacccagt ccggtaagtt ccaccacatt cccttttcct ttcaggcttg
    13981 acgcaatata attgcctacc gcacgtccta tttcataatt gtcggcaccg atataggcag
    14041 tatatttatc agaaagaatc ttccggtcta ccaagatgac aggtattccc ttttgatagg
    14101 cttcctctac aatcggagtc atgggggccg cttcgttggc agagataatc aataagtcaa
    14161 ccccttcatc tataaaataa tgaacgtctt ccgcctgttt acgattatca tccgcagccg
    14221 accggatttc aaccgatact ccatcataaa acattgcttc gcggagaatt tcatcattca
    14281 tcttatgccg ccaagagtca tcgctgcatt gcgccacccc gatacggaaa cggtgtgtgt
    14341 cctgccgaca agccgtcatg ccaagaagac agagcaagac tgctatccac ttcgtatatc
    14401 ccatcattct aatcattctc atttttttcg tatttctttc tatgacccaa atggacgatt
    14461 gagaacaaaa ataagaaata aaactgtgag tatgctatct atcacccaat tattctcatc
    14521 attaccctcc aaagaaatgc aaaacagttc ccaatattca accggaaatt attaacaaaa
    14581 gtataaagcg taaaacaaac actcaataaa tgttataaaa catctctttt tatttggatt
    14641 atttgcagat ttagcagaag tccgtatctt tgcaatgtgt ttttcatagt attagattta
    14701 aggttaacaa aggttggagc aaggcgttgc tccttttttt atgtctgtac ggctacacct
    14761 tgcactctgt ataacaccta caacctatat gacagttgat aagacctagt tttcatccca
    14821 ttccctttcc agtttgccat caatggtata aagtttccaa cgtcctaccc ggtgaccgtt
    14881 cttatattct ccacattcgc ggagcttgtt attcttcaca taacgagatt caaaaggacc
    14941 gttttgccgt ccgttgacgt atgtagaagt ttcccaataa tcaaagcgat tgtccaccac
    15001 taactggcgt gcttttccgt gcagtctgcc aaactgatag gttgcctcgt acttcaattc
    15061 gccatttttc aagtcatatt cacgatagat tccgtccttg cggtcatttt tcagataata
    15121 ttctttggta cgcatccctg tctcaccact gtatgaaacg tgcaggcctt cttcttttcc
    15181 attcagataa gtttcaatta caatggtatc gccactctct gcaatctctg tccaacgacc
    15241 gttcttctgc ccattcttgt aactacccaa cacatgagga gctccaaaag taaagatgga
    15301 cgaatattct ccatccttca acccttcgtt attataataa accgtttcgt atagttcata
    15361 agtccccttc atgaaagtat attgtttccc tacttgttta ccatccttat aattatggtc
    15421 catccgcaga gttccgtcat agtcatacga caaatgtttt ccatcctcct tgcccatccg
    15481 gtagtttttc tcactttcta tttttccgtc agtaaagaac gttttgctcg taccgttcaa
    15541 ctttccttcc ttataagact tttcttcttt cagtttaccg tcaaacttag aatagatttt
    15601 aaataagcca ttcttccgtc catctttgta gacgccttca tttatcagaa tgttatccaa
    15661 atgctcttca tatttgccat cataaaaacc atctttaaaa gaggccagta tatacgcaga
    15721 gtgataaccg tcaatgatac gatgttcgcc gttgagcggt ttttccgtca tcaagtctcg
    15781 gtacaagaat cttccgtcgc ctacattaac gacagatacc tgatcgattt taaactcttt
    15841 ttgtgctaat gagggaaggg ctatgcatag aagcaaaaat acattccagc atttcgagcg
    15901 gaataaaata gaaacgtgtt tcataatgtg acattctctt tttagttatt atcttgtgaa
    15961 tcgtgcaaag atatataatt agctaaaaat ccaacaataa aaagagaaga aaagaggtga
    16021 tatccgaaaa gatttgaatt taaaaaatcc tccttactac aacataccgt agtaagaagg
    16081 atttttcact ttaggattct tttcgtccct acatttacat caatagagaa attacatcag
    16141 cctgtctttc aaaacctgcg gaagttcggg cattgcaccg ctttgcgtgc agacataagc
    16201 agaaacttca acggcaagtt tatgagcttc aggaaccggt tttccattga gaatggaagc
    16261 acagaaagca gccgtaaagg aatcacctgc ccccaccgta t
//
