LOCUS       gnlProkkaFPGOFBJB_9    12212 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FPGOFBJB_9.
ACCESSION   gnlProkkaFPGOFBJB_9
VERSION     gnlProkkaFPGOFBJB_9
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 07:59:46
            Original ID  :: gnl|Prokka|FPGOFBJB_9
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 71857
            Orig. end    :: 84069
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12212
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10884]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10884
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..12212
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12212
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             1141..3534
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:diguanylate cyclase (Score: 93.2; E-value:
                     4.1e-28)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_61"
                     /transl_table=11
                     /translation="MTLDSLYIGVPIGAFFCFLFIFFSFLNAGDAKPVRYFRQILLSCL
                     IWTGGVVMMRMQIMPGMRFWFHVSVFGFLTVPIFMYAFLFYMLEIKKNGFLTGYCIATV
                     VAMGINVVTEVFIPEPDIIRYADGSIGYAYHLSWGSYLFAAAEAGVIVYTTVLAHRAIG
                     NKFEKRKKLFPLLLGTVAILTGNLFVALPGNFFPYDMLGGIFMALCLLYIMWHKYLFDI
                     SNRIVIGCIYSVALAVSLLPVFNFNHNAEWYLGSVLPEIQQKVIVLVLGFTGWSLFVFY
                     LARKMAEGIMQRQNRKQIEVLRRFQNESASILRQEDLFKLLVGVVNEMFPVKDIFVFIK
                     NGEKFTVVKTAGGQMPDQAEQDEITAMLERSGAGECSEISLMKYDDEIQGFIYIKSEKR
                     TRLNYLERDYYWRIGVYAGVCLKNISTYQEVYQISIHDELTGLYNRGYFKKFLAENWKE
                     EQKIALMYLDLDDFKLFNELYGEECGDRILKWCGHIIENTVGSKGETFRFGSNEYVVLI
                     NSDEKKKVAQIAAKIQKNFLLADEEKPDVLQPVTASVGIAFYPDTASGADELLSQAERA
                     NFYAKRDGKNCIKIYGAHTEDELEDQQVQKHYEQIAPTIYALTAAIDAKDSYTFEHSCH
                     VSDYAVLLAKKIGLEPNDIEIAKEAGLLHDIGKIGIPESILKKQGRLNDEEYEIMKTHV
                     TNSIEMIHFLPNMNYVIPAVLSHHERYDGKGYPRGLKGEDIPLLGRILAVCDSFDAMTT
                     KRTYKEAMSIDYAISELEHNKGTQFDPKLAEAFIELLKEGKIEV"
     CDS             3636..4334
                     /locus_tag="ctg9_62"
                     /transl_table=11
                     /translation="MWNRSELKSNAKLALKANYWKAVLVGLILSFILGSGSTAAQNSAR
                     SSTDGLTDIDPVMVFTVIGIILAAVFVAMVISILLSIFIWNPLEVGCQKFFINCKYGNA
                     ELGDMAYGFKNGYAHIGMIMFLRGLFTGLWMLLFIIPGIVKSYEYMMIPYLLAEHPEMT
                     RQEAFAESKQMMDGNKWDAFVLDLSFIGWTLLGVCTFGILLVFYVEPYIYLTRAELYHA
                     LKNNNKSVEF"
     CDS             4397..6241
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 153.6; E-value: 1.7e-46)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_63"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.7e-25, bitscore:
                     82.0, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGIFMSNEKMENLLNLALDATEREREKSLDLDTGYDRAERTWEV
                     IVKFGGTEEALRGLFAEKFPEEYDRIRITNLRNEYAILLLPEHIVELVAALTEIEYMEK
                     PKLLFFAVNNGRRVSCINQLQTVGTEQGTLSSGRNLSGTGVIVAVIDSGIDYTHPDFRN
                     ADGTTRILNLWDQTIPADSVADPFPAENGETSFLGAPSGYFLGTEFTRAVIDRALEQTT
                     ERERFALCPSRDISGHGTHVTGIAAGNGRASQGRYRGVAYESPLLIVKLGTPGERSFPR
                     TTELMQAVDYCIRKAQEYGMPIVINLSFGNNYGSHSGNSLLESYLDDMANYWRTSIVAG
                     SGNEGASAVHASGTLRENITKDVEIAVSSYEPSLNLQIWKNYSDEIAVSLIHPNGTRVG
                     PVRQILGPQRFRLGNTDILLYYGEPSPYSPYQEIYFDLLPVNEYIDSGVWTIQLVPQRI
                     AAGNYDMWLPAGGVLNEGTGFLMPSEETTLTIPSTAARVITVGAYDGYFDRAAAFSGRG
                     YTRETNQVKPDLVAPGVDITSCAPGGGYVTRSGTSMAAPFVTGGAALLMQWGIVDKNDP
                     YLYGEKMKAYLIKGARRLPAMRDYPNPVFGDNGIIVSS"
     CDS             6653..7342
                     /gene_functions="other (smcogs) SMCOG1157:hypothetical
                     protein (Score: 141.1; E-value: 8e-43)"
                     /gene_kind="other"
                     /locus_tag="ctg9_64"
                     /transl_table=11
                     /translation="MGKVLGIVNRKGGVGKTTTATTLSYLLSKEGCKVALIDFDGQRHT
                     TKLCGVTAPEQLSVTIYDILKCIVMNEELPDKGSYMIRTETGVDLIPANNKLDNFDKLM
                     CDTDFAEYKLKEFVDTIKEQYDYILIDGMPKMGTAMINVMICCDSLIIPVQSATLAVEG
                     MAEFLRAFHRIKSHANAETQQEKTKQCQRKQTDKKEICRTDTAYGRVDERDTFWGWTGE
                     EVSLIPP"
     CDS             7595..7936
                     /gene_functions="other (smcogs) SMCOG1148:hypothetical
                     protein (Score: 56.3; E-value: 8.6e-17)"
                     /gene_kind="other"
                     /locus_tag="ctg9_65"
                     /transl_table=11
                     /translation="MKLDYCAIGMRIKERRTKKEWSQEMLASTVGISNPHMSNIERGKT
                     KVSLATLIDIANPLDTTLDALICDNLVKGKVVFDEEISQELEECSEEDIRIVYDMVKAL
                     VKSLAKRKH"
     CDS             7937..8677
                     /locus_tag="ctg9_66"
                     /transl_table=11
                     /translation="MLQWGQRYMIRIGICDDLVEQLQIQEEMVRNIVCRLGLNTEIKCF
                     QSGEDLLWEMEQKGNMDIILLDIEMGGINGVETARRIREKDNRAILFFISYYEQYCKEI
                     INVQPFRFIDKPVSEEELDRGFREAFKAMSQKEEIFEYTYKKVPYKILVNKIRYFESDK
                     RQVNLYSTDGVSSFYKKLDEVEAQLEQMNIKFLRISKSYLVNVNYVKEFRYEKVVMDDG
                     KEFKIGPRYKDKIRKSYIELMRIS"
     CDS             8678..9973
                     /locus_tag="ctg9_67"
                     /transl_table=11
                     /translation="MMKVMLAAIEIFSLVYQRIFAQKVLTQRKHSRVWECFVWGMYFVI
                     SNFFTYSFAKSAWDNTGIFVVSFFFALRILYIDSAWVLSAVTAFMAISGALSEVLTYYG
                     WQIFVQKSGVKVDTANEDYLLLLVSKLVMFFFIKILLALIKRHKNIRLNTQEWVEIFMI
                     PGGSIVILAEMICQKESMSETLDFVAALMVMLINIFTYYLYDKIGETAEKRVREEVLQE
                     QSEYYLRQYNENMNLWVEMSEFRHNMTERYLMEKMYLEKGDYEALKKYCDNSLEKLHKQ
                     RKVSNTGCFYFDSIINYKAAVAETFDIKFETKLMIPRDLKVETEDICICLGNLLDNAIE
                     ASKKVKAEERSVCVEIRVDRRNLMMMVSNHYEEERKKSGNHYMTTKKEKHRHGFGLNII
                     RKIARRYDGEVIIDDGNHQFVVTVLLYEIFSM"
     CDS             10001..10288
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_68"
                     /sec_met_domain="TIGR04223 (E-value: 1.3e-14, bitscore:
                     46.2, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSERQASLFFLHKNKKVTDNHTILDVLKILCRKMVLLGKKRGGIK
                     MKNLLNRYLSNLMTFGLEKVATGAATKCCYFILHQPKVPENLKKFSESKK"
     CDS             10285..10884
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_69"
                     /sec_met_domain="AgrB (E-value: 2e-34, bitscore: 110.7,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKLFERIVDFMEENGSIQSEYRDVYLFALQTIAVYAFNIGTGVV
                     IGAAFGELLYCMIFLIAFMLLRQEAGGYHAPGWMSCYFLSCGILVLTLLWIKAEFAYQT
                     CLTIAAALAAGMGIFLFAPLEDKNKPLEEAEKKVIGKKARIIVVTELILGMVFLAVNQR
                     AAYAVLGAVIWCGVSYLAWSVKRYTEKNGKSREDNN"
     CDS             10856..12211
                     /locus_tag="ctg9_70"
                     /transl_table=11
                     /translation="MGKVEKITIKLAMLFIGLSLLFPARVLAAEKNEINEITEKKQIIF
                     LLDASKSMQGDGQWIEAADSACMIASALPEEYEVALLVYNTEIVYEEDFGNINQKTRHA
                     LETVELQGYTTPAVGLETAADMFDSAAAEKRVVFISDGEISLREQSETEAAIRQFENMV
                     DQIAEQGIKIDMFAIPNDKTENEVSYGTKVTSGEQYTVGENQTIEEITAKYLFQTLQIE
                     KIELGEAVSGEGNMTVDLQDTYMQNAKILLVSGENIEDFHVAGQCESLNMLQGNKFAVA
                     ELENPLEQQITMDYSLENRGNVHTYLIKEYFLKADMEKSYTSEEGTFTLKVNVVNHQEK
                     PVLDSETLKDSISVLINGKEASYRVENGTAMVPYQTDETAKVNVEIAIQPSGNVVHYIK
                     TADTVELTVPVVEEEPDYTVLWIVIVSLCAVVLLLSVLYERKKQKKNDGETGS"
ORIGIN
        1 acgtatttaa gacttcaccg tgttccctct ggtaagcggc agcaagggct gtgacgatgc
       61 ttgaatcgat gcccccggat aaaaaggtac agaccggcac atcggagatc atctgccgtt
      121 ttacggtatc gcgcatgaga aaagatacat gtgccacggt gtcctcgtag gagtccgtgt
      181 ggggcagaca tttcagatcc cagtaggtgg tatcggagag ccccatggca tcaaaacaca
      241 ggtaatgtcc gggtagaact tcatagatat cctgaaaaac cccacatccg ggggtgcgcg
      301 ccggcccgac tgcaagcagt tctctcaggc tgttttcggt aatagcgggt gaaagatccg
      361 gaaagcagaa cagtgctttt ggctctgagg caaagacaag ctcaccgtct tttgcgtgat
      421 aaaaaagcgg ctttgtccct actctgtcgc ggtagagaaa aagctgtttt gcggcaccgt
      481 cccagatggc aaaggaaaag attccattta agcgggagac aaaggaagca ccgaaatgca
      541 tgtaggcata taagatcact tccgtgtcgg atgttgtgag aaaattatat ccggcagcag
      601 taagctccgg gatcagttca tcggtattat agatctcccc attgtagacg atggcataat
      661 ctgccccgtc ccggtgacgt atcataggct gtgcaccgtg cgtgatatca cggatagaaa
      721 gtctctgatg tgacagaccg gcatgaggtg tcagataaat gccggaagca tcaccgccgc
      781 ggtggatgag tttttcgtgc atggacacca gtatattttc ccaaaaggac tgtctgtccg
      841 tataacagcg tttcaggctg caaaatcctg caattccgca cataaggtca ctccattaaa
      901 aaacatattt aatccctgtt agtgtatgca aatccatcaa aaagatgatg gattcccatc
      961 aaaaagatga tggatgatgg aaaaaaatgg aattgcaggt taaaatatgc tataatgagc
     1021 gaaagagagt caacatgctt gtatgattga cgaattgtga attggatcat gtgccgattt
     1081 tgcacatgaa tataatgatt gattttgaaa aattttacat tcaatttgga ggaaacggct
     1141 ttgacgctgg atagtttata tattggagtt ccaatcggag cgtttttctg ttttttattt
     1201 atattttttt cattcctgaa tgccggggat gcaaaaccgg tcaggtattt cagacagatt
     1261 cttttatcct gtctgatctg gactggcggt gtagtaatga tgcgtatgca gatcatgccg
     1321 gggatgcggt tctggtttca tgtgtcggta ttcggatttt tgacggtacc gatttttatg
     1381 tatgcatttt tattttatat gttggagatc aaaaagaatg gtttcctgac cggatattgc
     1441 atagctactg tggtggcaat ggggatcaat gttgtcacag aagtatttat cccggaaccg
     1501 gatattatcc ggtatgcaga tggaagcatt ggatatgcct atcatctatc ttggggaagt
     1561 tatttatttg cagctgcgga ggcaggtgtg atcgtctata cgacagtttt ggcgcacagg
     1621 gcaatcggca ataaatttga aaaacgaaag aaattatttc cactgctgct tggaacagtt
     1681 gcaattttga caggcaatct ttttgttgca ctgccgggta attttttccc gtatgatatg
     1741 ctgggcggta tttttatggc attgtgcctg ttatatatca tgtggcacaa gtatctgttt
     1801 gatatctcga accgtatcgt gatcggatgt atctactcgg ttgcactggc ggtcagtctt
     1861 cttcctgtgt tcaattttaa tcacaatgcg gagtggtatc ttggcagtgt attgccggaa
     1921 atacagcaaa aagttatagt gctcgtactt ggatttacag gatggtcgtt gtttgtattt
     1981 tatctggcaa gaaaaatggc agagggaatc atgcagaggc agaacagaaa gcagatcgag
     2041 gtattacgtc gttttcagaa tgagtcggcg tctatattgc ggcaggaaga tctgtttaag
     2101 ctgctggttg gtgtggtaaa tgagatgttt ccggtaaagg acatctttgt ttttatcaaa
     2161 aatggagaaa agtttacggt tgtaaaaaca gccggtggac agatgccgga tcaggcagag
     2221 caggatgaaa tcacggctat gctggaaaga tcgggggcag gtgagtgctc tgagatttca
     2281 ttgatgaagt atgatgatga gatacaggga tttatctata taaaatcgga gaaaagaacc
     2341 agattaaatt atttagagag agattattac tggagaattg gtgtgtatgc gggtgtgtgc
     2401 cttaagaata tcagcactta tcaggaagta tatcagatat cgattcatga tgaactgaca
     2461 gggctttata acaggggata ttttaaaaag tttctggcgg agaactggaa agaagagcag
     2521 aagatagctc tgatgtatct tgatctggat gattttaagc tttttaatga gctgtacggg
     2581 gaagaatgtg gggatcgcat attaaaatgg tgcgggcata tcatagagaa tactgtagga
     2641 agtaagggag aaacattccg gtttggatca aatgaatatg tggtgctgat aaattcggat
     2701 gaaaagaaaa aggtggcaca gattgcggcg aagatacaga agaattttct gctcgcggat
     2761 gaagaaaaac cggatgttct acaaccggtg actgcaagtg tcggaattgc attttatccg
     2821 gatacggctt cgggagcgga tgagctgctc agtcaggcag aacgtgcaaa tttttatgca
     2881 aaacgggacg gaaaaaactg tattaaaatt tatggagcac atacagaaga tgaacttgag
     2941 gatcagcagg tacaaaagca ttatgaacag attgcaccaa cgatttacgc actgactgca
     3001 gcaatcgatg caaaggattc ttataccttt gaacattcct gccatgtatc ggattatgcg
     3061 gttcttctcg caaaaaaaat aggtcttgag ccgaatgaca ttgaaattgc aaaggaggca
     3121 ggactgcttc acgatatcgg aaagattggt attcctgaga gtatcttaaa aaaacagggc
     3181 aggttaaatg atgaggaata tgagatcatg aaaacacatg tcacgaattc cattgagatg
     3241 attcattttc tgccgaatat gaactatgtg ataccggctg tattatcgca tcatgagaga
     3301 tatgacggaa agggatatcc gagaggcctg aaaggagaag atattccact gttagggcgt
     3361 attcttgcgg tatgtgattc gtttgatgcg atgacaacaa agcgtaccta caaggaagct
     3421 atgtcgatcg attatgcaat cagtgagtta gaacacaata agggaacaca gtttgatcca
     3481 aaactggcag aggcatttat tgaattgtta aaagaaggga aaattgaggt ctaattctta
     3541 agattttctg aggatttttg tttgagggat gacaaaaaaa cgttaatgtg ttaaactgca
     3601 aaagtgtaaa atgtttttat caggaggagt ttaacatgtg gaacagaagt gagttaaaaa
     3661 gcaatgcaaa gctggcattg aaggcgaatt actggaaagc agtgctggtg ggactgattc
     3721 tgtcatttat tttaggttca ggctcaacag ctgcccaaaa ttcggcaagg tcatcaacgg
     3781 atggattgac ggatatagat ccggtaatgg tatttactgt gattgggatt atactggcag
     3841 cagtatttgt tgccatggtg atcagcatcc tgctcagtat ttttatctgg aatccgcttg
     3901 aagtgggatg tcagaaattt ttcattaact gtaagtatgg taacgcggaa ttaggcgata
     3961 tggcatacgg atttaaaaac ggatatgcgc acatcggcat gatcatgttc ctgcgggggc
     4021 tgtttacagg actctggatg ttattattta tcattccggg tatcgtgaaa agttatgagt
     4081 atatgatgat cccatatctt ttagcagagc atccggagat gaccagacag gaagcctttg
     4141 cagaaagtaa acagatgatg gatggaaaca aatgggatgc atttgtgtta gatctttcat
     4201 ttatcggctg gacgctgtta ggtgtctgca catttggtat tcttcttgtt ttttatgtag
     4261 aaccttacat atatctgaca cgcgcagaac tgtatcatgc attaaaaaat aataataagt
     4321 cggtagaatt ttaaatttac cccaaaagag tcataaaatc cccccaagct gcatttctaa
     4381 taagtaagga gtgcgtttgc gggggatttt tatgtccaat gagaaaatgg aaaatctgtt
     4441 aaatcttgca ctcgatgcga cagagcggga gagggaaaaa tcgttagatc tcgataccgg
     4501 gtatgacaga gcggaacgga cctgggaagt tatcgtaaaa ttcggaggca cggaagaagc
     4561 gttgagggga ctgtttgcag aaaaatttcc ggaggagtat gaccggatca ggattacaaa
     4621 tctgcggaat gaatatgcga tcctgctttt gccagagcat attgtggaac tggtggcggc
     4681 actgacagag atcgaataca tggagaaacc gaaacttttg ttttttgcag tgaataacgg
     4741 cagacgtgta tcatgcatca atcagctgca gacggtgggg acggagcagg gaacattgtc
     4801 gtctggcaga aatttaagtg gaaccggcgt gatcgtggca gtgatcgatt ccggcatcga
     4861 ttatacacac ccggattttc ggaatgcaga cggaaccacc cggattttaa atctgtggga
     4921 tcagacgata ccagcagaca gcgtggcaga tccgtttcct gcggagaatg gagaaacgtc
     4981 atttttaggg gcaccgtcag ggtactttct tggaactgaa tttacgagag cggtgataga
     5041 ccgcgcttta gagcagacaa cggagagaga gcggtttgcg ttgtgcccca gccgtgacat
     5101 ctccgggcat ggcacccatg tgacggggat cgcagccgga aatggcagag cctcacaggg
     5161 aagataccgc ggagtggcat atgaaagtcc gcttctgatc gtaaaattgg gaacgccggg
     5221 ggaacgatct tttccaagaa cgacggaact gatgcaggca gtagattact gtatcagaaa
     5281 agcccaggaa tacgggatgc ccatcgttat aaatttgagc tttgggaata actatggttc
     5341 ccactccggc aactccctgt tagagagtta tcttgatgat atggcgaatt actggcggac
     5401 gtcgattgtt gccggcagcg gaaatgaggg ggcgtcggcg gtgcatgcgt ctggaaccct
     5461 gcgggaaaat atcacgaaag atgtggaaat cgccgtgagc agttatgagc cgtctttaaa
     5521 tcttcaaatt tggaaaaatt attccgatga gattgcggtc tcgctgattc atccgaatgg
     5581 tacgagagtg ggaccagtcc ggcagatttt aggtccgcag cgttttaggc tggggaatac
     5641 agatattctg ctttattacg gagaaccgag tccctacagt ccttatcagg aaatttattt
     5701 tgacctgctt ccggtaaacg agtatattga cagcggcgtc tggacgatac agcttgtacc
     5761 acagagaatt gcagccggaa attatgatat gtggcttccg gcgggcggtg ttttaaacga
     5821 aggtacgggc tttttgatgc cgtcggagga gacaacactg acgattccgt cgacggcggc
     5881 gcgggtgatc accgtcggag cctacgacgg atattttgac cgcgcggcgg cattttccgg
     5941 gcgcgggtat acgcgggaga ccaatcaggt caaaccggat ctggtcgcac cgggggtgga
     6001 tattacttcc tgtgcgccgg gcggcgggta tgtgacaaga agcggaacat cgatggcggc
     6061 tccctttgtg actggcgggg cagcacttct gatgcaatgg gggatcgtgg ataaaaatga
     6121 tccatatctg tatggggaaa aaatgaaagc gtatctgatc aagggggcaa gaaggcttcc
     6181 ggcgatgcgg gactatccga atccggtgtt tggggataat ggtattatag tgtcaagtta
     6241 gtgagaagcc agtaaaatca aggggttccg ctgatttcgt ccaaaacaga aattgctgtg
     6301 aaaacggcaa attgggatga aaacaacctg gttttcattc tgaaaaaggg aaatcggata
     6361 acttgacact aaaataccat aaggagttaa aaatctattt ttcaagtgta tttcaaattt
     6421 atcatttcta atcaatctca gttttagtgc aaaatctatt ttccaaattg taaccgatag
     6481 tgttcttaca tggaaggagg taagtgaaca gtcctacttt tatccaagtg tcatatgaaa
     6541 ttgataccat ggcagtcgcc aaggttcagc aagcctggcc ttggctcgct gcctgcatga
     6601 gaatccaatg taaccaaaat aacaaattca acaagagaaa ggaagcaaac gtatgggcaa
     6661 ggttttagga attgtaaaca gaaagggcgg agtaggtaag accacgaccg ccacaaccct
     6721 gtcatatctg ctgtctaagg agggctgtaa ggtcgcattg attgactttg acgggcagag
     6781 gcacacaaca aaactttgcg gagtgaccgc accagagcag ctttccgtga caatttatga
     6841 cattttgaag tgtatcgtga tgaacgaaga actgccggat aaagggtcct acatgataag
     6901 gacagagaca ggagtagatt taattccggc gaataacaag ctggataact ttgataagct
     6961 gatgtgtgat actgattttg cagaatacaa gctgaaagag tttgtggaca ccattaagga
     7021 gcagtatgac tacatcctca ttgacgggat gcctaagatg gggacagcca tgataaatgt
     7081 gatgatatgc tgtgacagtc tgattattcc ggtacagtcg gcaacgctgg cggtagaggg
     7141 aatggcagag tttctaaggg ctttccacag aatcaagagc cacgcaaatg cagagacgca
     7201 gcaggagaaa actaagcaat gtcaaaggaa acagactgat aaaaaggaga tttgcagaac
     7261 agacacagcg tatggaagag tggacgaaag agacaccttt tgggggtgga ctggggagga
     7321 ggtcagtttg ataccacctt gaacgttcat tttaactaaa agactaaaaa gtgaaaaaaa
     7381 aagtatttag gataaaatag aaatatagtc tggttacaca ttggtaataa acgtaaaatg
     7441 acgtatatgt taagcttaaa atgataattt tgcaaataaa ataaaaaatt tcttgtagat
     7501 tattaaacca tagcaaaata aattagtata cagagcattc ttaaatagtc aaagaaaaga
     7561 tatgataaaa ggaaaatgag tttcggagat agaaatgaaa ttagattatt gcgcaatagg
     7621 tatgagaata aaagagcgtc ggacgaagaa agaatggtcg caggagatgc tggcatctac
     7681 tgttggaatt tccaatccac atatgagtaa tatagagcgg ggaaagacaa aagtaagctt
     7741 ggcaactttg atagatattg caaaccctct ggatacgaca ttggacgcat tgatttgtga
     7801 taatctggtg aaagggaaag ttgtttttga tgaagaaatt tcacaggaat tggaagaatg
     7861 cagtgaagaa gacatcagaa ttgtttatga tatggtaaaa gctttggtta agagtctggc
     7921 aaaacggaaa cattagttgt tacagtgggg gcaaagatat atgataagga tcgggatttg
     7981 tgatgattta gtagaacaac ttcagataca ggaagagatg gttaggaata tcgtttgccg
     8041 tttggggctg aatacagaaa taaaatgttt tcaaagtgga gaagatttgc tatgggaaat
     8101 ggaacaaaaa ggcaatatgg atatcattct tttggatatt gaaatgggcg ggataaacgg
     8161 agttgaaacg gcaagacgga ttcgggaaaa ggataacagg gcaattttgt tcttcatttc
     8221 ctactatgaa cagtattgta aggaaatcat taatgtacag ccatttcggt ttatagacaa
     8281 gcctgtttcg gaggaggaac tggatcgtgg gtttagagaa gcgtttaagg cgatgagtca
     8341 aaaagaagaa atttttgagt atacatataa aaaagttcca tataagattt tggtaaataa
     8401 aattcgttat tttgagagtg ataagcgaca ggtgaatctt tacagtacag acggtgtttc
     8461 ttccttttat aaaaaactgg atgaagtaga agcacagtta gaacagatga atatcaagtt
     8521 tttaaggatt agtaaatctt atctggtcaa tgtgaactat gtaaaggaat ttcggtatga
     8581 aaaagtagtg atggatgacg gcaaagaatt taaaataggt cccagatata aggataaaat
     8641 acgaaaaagt tatattgaat tgatgaggat aagctaaatg atgaaagtaa tgctggcagc
     8701 cattgaaatt ttttctttag tgtatcagag aatttttgca caaaaagtcc tgacacaaag
     8761 aaagcatagc agagtgtggg agtgttttgt atggggaatg tattttgtta tttctaattt
     8821 ttttacttac agttttgcaa aaagtgcgtg ggacaataca ggaatatttg ttgtctcatt
     8881 tttttttgct ttacgtattt tatatataga ttctgcatgg gttttatcgg cagttactgc
     8941 ttttatggca attagcggag cattatcaga agtattgact tattatggat ggcagatatt
     9001 tgttcagaaa agtggagtca aagtagatac ggcaaatgag gattacttac tattgctggt
     9061 ttccaagcta gttatgtttt tctttataaa aatattgctg gcacttatca agcggcataa
     9121 aaatatcagg ttgaatacac aggaatgggt tgaaattttt atgattcccg gaggaagcat
     9181 tgtcatttta gctgaaatga tctgtcaaaa ggaaagcatg agtgagacat tggattttgt
     9241 ggcagcgctt atggtaatgc tgataaatat ttttacatat tatttgtatg ataaaattgg
     9301 agaaacagca gaaaaaagag tacgggaaga ggttttacag gagcaaagtg aatattatct
     9361 cagacagtac aatgaaaaca tgaatctgtg ggtagaaatg agtgagttcc gccataatat
     9421 gacggaacgg tatctgatgg agaaaatgta tctggagaaa ggagactatg aggcactcaa
     9481 aaaatattgc gataattctt tagaaaagtt acataagcag agaaaagtat ctaatacagg
     9541 gtgtttctat tttgacagta ttattaacta taaagcggcg gttgctgaga catttgatat
     9601 taaatttgaa acaaagctga tgataccgag agatttaaaa gtggaaacag aagatatctg
     9661 tatctgtctt ggaaatttgt tggataatgc gatagaggca tccaaaaaag tgaaagcaga
     9721 agaacgtagt gtttgcgtag aaatacgagt ggatagaaga aaccttatga tgatggtttc
     9781 taaccattac gaagaagaac ggaaaaagag cggaaatcat tatatgacaa caaaaaaaga
     9841 aaaacacagg catggatttg gactgaatat aataaggaag atagccagac ggtatgatgg
     9901 ggaggttatc attgatgatg ggaatcatca atttgtggtg acagtattat tgtatgagat
     9961 tttttctatg taaaaaaatg taaagggaaa taagagatgc gtgagtgaga gacaggcgtc
    10021 tctttttttt ttgcataaaa ataaaaaagt tacagataac catacgattc ttgacgtttt
    10081 gaagattctg tgtcgaaaaa tggtattatt aggaaaaaag agagggggaa tcaagatgaa
    10141 aaatctgtta aaccgctatt tgagcaattt aatgacattt ggactggaga aagtagcaac
    10201 aggcgctgca acaaaatgct gctattttat tctgcatcag cccaaggtgc cggaaaatct
    10261 caaaaagttt tctgagagta agaaatgaga aaactttttg aaagaatcgt agacttcatg
    10321 gaagaaaatg gaagcattca atcggagtac agggatgtat atctatttgc gttgcagacc
    10381 attgctgtat atgctttcaa tattggaacg ggtgttgtca ttggcgcagc ctttggggaa
    10441 ttgttatatt gcatgatatt tctgattgca tttatgctgt tgcggcagga agcaggagga
    10501 tatcacgcac cgggatggat gagctgctat tttctttcat gtgggattct ggttttaacc
    10561 ttgttatgga taaaagcaga atttgcttat cagacctgtc ttacaatcgc tgcggcgttg
    10621 gctgcgggga tggggatatt tctatttgct cctctggagg ataaaaataa gcctctggag
    10681 gaagcagaaa agaaagtaat cggaaaaaag gcgcgaatca tagttgtaac agagctgata
    10741 ctcggaatgg tattcttagc ggtaaatcag agagctgcat atgcggtttt gggcgcagtt
    10801 atctggtgtg gagtgagtta tctggcatgg tcagtaaaaa gatatacgga gaaaaatggg
    10861 aaaagtagag aagataacaa ttaaattggc aatgctgttc atagggcttt ctttgctgtt
    10921 tccggcaagg gttttggcag cggagaagaa tgaaatcaat gaaatcaccg aaaaaaagca
    10981 gattatattt ttgttggatg caagtaagtc catgcaggga gacggacagt ggattgaggc
    11041 ggcagacagt gcatgtatga tagcatcggc gctgccggaa gagtatgaag tggcgttgct
    11101 tgtatataac acggaaattg tttatgagga agattttgga aatattaacc agaaaaccag
    11161 gcatgcactt gagacggtag agctgcaggg ctataccacc ccggcggtgg gattggaaac
    11221 agcggctgac atgtttgaca gtgcggcggc agagaaaaga gtggtattta tttccgatgg
    11281 agaaatttct ctgcgggaac aaagtgaaac agaagctgca atcaggcagt ttgaaaatat
    11341 ggtggatcag attgcagaac agggaataaa aattgacatg tttgcaatcc ccaatgataa
    11401 gacggagaat gaggtttcgt atggaacgaa agtgacgtca ggagagcagt atacagtagg
    11461 cgaaaaccag acgattgaag aaatcactgc aaaatatctg ttccagacgt tacagataga
    11521 aaaaatagaa cttggcgagg cggtttcggg cgaaggaaat atgacggtgg atttgcagga
    11581 tacttatatg cagaatgcaa agatacttct tgtgtcaggg gaaaacattg aggattttca
    11641 tgttgcggga caatgtgaaa gcctgaatat gctccaggga aacaagtttg cagttgccga
    11701 attggaaaat ccgttagaac agcagattac gatggactat tcgttggaaa acagaggaaa
    11761 tgtccatact tatctgataa aagaatattt tttaaaagct gatatggaga aatcctatac
    11821 atcagaggaa gggacattta ccctgaaggt aaatgttgta aaccatcagg agaagccggt
    11881 tttggattcg gaaactttaa aagacagtat ttctgttttg attaatggca aggaagcgtc
    11941 ttaccgtgtg gaaaatggca cggcgatggt tccgtatcag acagacgaga cggcaaaagt
    12001 gaatgtggaa attgcaattc agccgtcggg aaatgtggtt cattacataa aaacggcaga
    12061 tacggtggaa ctgacagttc cggttgtaga ggaggaacct gattatacgg ttctttggat
    12121 tgtaattgta tctttatgtg cagtggtgct tttgctctct gttttatatg aaaggaaaaa
    12181 gcaaaaaaaa aacgatggtg agacgggttc ca
//
