LOCUS       c00058_gnlPro..        16951 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MBIHEHPF_58.
ACCESSION   c00058_gnlPro..
VERSION     c00058_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 18:33:08
            Original ID  :: gnl|Prokka|MBIHEHPF_58
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16951
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16951
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4690:6951]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4691..6951
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..16951
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16951
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(296..748)
                     /locus_tag="ctg58_1"
                     /transl_table=11
                     /translation="MLMPSIFGENLFDDDWMNFPFNDEFWGKKNPLYGKHAQNMMKTDI
                     RETDGSYELDVDLPGFKKDEIKVQLKDGYLTLAAAKGLDKDEKDKEGNYIRRERYAGTL
                     SRSFYVGDAVSEEDIHAKYEDGILKLSVPKKAPKAVEKNGYIAIEG"
     CDS             complement(910..1368)
                     /locus_tag="ctg58_2"
                     /transl_table=11
                     /translation="MLMPSIFGESLFDDFFTPFYYDDKDEKKAEKKLYGHRAQNLLKTD
                     IKETKEGYELVIDVPGFKKEEVKVALKDGYLTVSAAKGLDEEQDDKKTGRYIRRERYAG
                     ACERSFYVGEDVTQEDIKGEYKHGILKLFVPKKEAKPVSNDPKYITIE"
     CDS             complement(1713..1805)
                     /locus_tag="ctg58_3"
                     /transl_table=11
                     /translation="MNIYNHIAEMAHVENEMSKMNLPETVPAVV"
     CDS             complement(1802..2989)
                     /locus_tag="ctg58_4"
                     /transl_table=11
                     /translation="MARKDNKGRNLKTGESQRPDGRYMYRYKDELTGKRVTIYDMDLAS
                     LREQEKKINKDIDDQLITDTSVKKLTVNGLFERYMATKNIREKTKKDYWRTWNYRIKNT
                     LGNIRVVDFKTSHVRTFFSGLSDEGLAHSTIKSMYALLNPAFNMAVEDGIIRKNPVTGT
                     LGDYGAAAKEKEALTLEQQEKLLKFVENSKVYKPHLPMMQIMFGACLRISETIGLTWSD
                     VDMKNREIHVNGQLVYYEGEEGYCFHDWETKTDAGIRTIPMTQTVYDAFRKQKELNLML
                     GLQSNVEIGKRSGFIFNTKHGRPIMPAGVNSFLKNIVNAYNKRETILAENENREPELMP
                     HISAHILRHTGCTRLGENNVNPKVMQYVMGCWMSSGHSFSTDRSGAKNILMRRSL"
     CDS             complement(3083..3190)
                     /locus_tag="ctg58_5"
                     /transl_table=11
                     /translation="MDENRRKQRISFGMRVQRKIGVFQEFTLGNPKILC"
     CDS             complement(3190..3384)
                     /locus_tag="ctg58_6"
                     /transl_table=11
                     /translation="MRKTTEYNTENRLTVDIEGLMAMLSCGAVTARKIADCAEAKIIVG
                     RRVLYNVDKIKKYLDAMAV"
     CDS             3992..4546
                     /locus_tag="ctg58_7"
                     /transl_table=11
                     /translation="MTIGDKIKKIRTFRNMTQAELGAALGWGDKGANRLAQYETNYRVP
                     RKDLVTEMAKILDVNPIALYEPTIMNAEELMETLFWIDEFNPGMIKLFQLETYPGEKCN
                     SSEDTAVRYHDSDDWPVHPPVGMWFNYGVLNDFLKEWTLRKEELKSGVITRDEYFEWKI
                     NWPQTCDDCGKYEPQKHWKKS"
     CDS             complement(4691..5392)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_17"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: 101; E-value: 1.2e-31)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg58_8"
                     /sec_met_domain="Fer2_3 (E-value: 3.8e-32, bitscore: 101.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_17 (E-value: 1.4e-07, bitscore: 22.4,
                     seeds: 82, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00076, bitscore: 10.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYTIRIKRQENKEAKPFWQEFEIEAEGELSIAAMLNELNARQKL
                     TDKSGKEAEPISWECGCMVKKCGACAMRINGLPELACSTFLQSLKGKVIVLEPLSKFPV
                     VKDLIVDRSVVFENLKKINLWLESDAYMTEYTHEIRYQSARCLMCGCCLEVCPNFDFGK
                     DFAGAIAPVNAYRILNEEQDTSHHEQIAEKYRKHYFEGCGKSLSCQNICPAGIPVEELM
                     VRSNAAAVWKK"
     CDS             complement(5395..6951)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 273.7; E-value:
                     1e-83)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg58_9"
                     /sec_met_domain="FAD_binding_2 (E-value: 3.1e-84, bitscore:
                     273.7, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 5.4e-17,
                     bitscore: 52.4, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKNMIIVGAGLAGLSAALQAVKEGCSVKLISSLPSERAQSVMAE
                     GGINAALNTKGEDDSTQEHYEDTIKAGCNLADPNAVWNMTQAAPEVVKWLHSIGVQFNT
                     CGYDELDLRNFGGQKKKRTAFAKSDTGKQIMTAMIDAVRRLEVQGQIERFEHHSFRTLL
                     MTANICHGCVVCDNYTGEIKMLYADAVIVASGGMHGLFGNTTGSLANTGEVSASLFSAG
                     VPMANLEMIQYHPTTVEIGGKKMLISEAARGEGGRLFTYRDGNRWYFMEEKYPELGNLM
                     PRDITAREIWKISKESPVYLDMTEIPKDVTDRKLAGLVSDCQIYLHKDIRKEPVQVVPG
                     IHYFMGGIYVDEKHRTPVRNLYAAGECCAQYHGANRLGGNSLLGAIYGGRIAAQTACED
                     AMTAKDMLVTETQELADLCESISQPDKKKINKIMLNTLGVVRNRKRMEEELEKLCQIKG
                     SLSLLGQAAIMSAIERTESRGAHYREDYPKKNDDFARTTIASYNGQKIQIHFEEIPERR
                     Q"
     CDS             complement(6948..7487)
                     /locus_tag="ctg58_10"
                     /transl_table=11
                     /translation="MRKINTILSVLLLVIFMLHGLMGSFMLLGIGSSAGKILAWVGVAV
                     LAAHTVIGVILTINTLKISKNAGNSYLKQNAVFWARRASGLAILILMFFHIGLFGGVQD
                     GIYILFPFTTVKLITQLLLVAALFIHLFINIRPLLVSLGIISYKERRGDIYLILSVLLL
                     FSAGAVIIYYIGWHTL"
     CDS             complement(7496..8005)
                     /locus_tag="ctg58_11"
                     /transl_table=11
                     /translation="VKRRLILLVVVIALIAGFGALLHSPPSIIDAVTGATPKAKKAAQS
                     SAQLEGSYIFCMNPLLDKLSDEDIREQLKAFVTGKTDSIRTDTELSFDIYVSETDYALI
                     RYADSLCERLNDAGADVQIKQYSGTMLRSRAVSGKYEAFLSESDLVSTDALENADYIIL
                     DSAEMR"
     CDS             complement(8020..10602)
                     /locus_tag="ctg58_12"
                     /transl_table=11
                     /translation="MERIFLLKGLDCPNCSAKIEKEVGDLENVNSSSVNLMKQTLTIQT
                     ETFDNSIVEQIETIVHSHEPDVEVSEKKESYTTKTYLLKGLDCPNCSAKIEKEVGDLED
                     VSSSVVNLMKQTLTISVKTSASGKIQDEVATIVHSHEPDVKVSEQTDSYVTKKYLLKGL
                     DCPNCSAKIEKEVGELEGVALSEVNLMKQTLTVSMDHNKAASMLDMVTTIVHSHEPDVE
                     VSEQKADTSVAPDKKEKTPVYSDDDKKLTIRLISGAVIYAVGMGLTLFGHVSLPVELGV
                     LIVAYIILGWDVVWQAVKNITRGQIFDEHFLMSLSTIGAFAIGEYPEAVAVMLFYQVGE
                     FFQSLAVKRSRKSISDLMDIRPDSATVRRNGELVVVAPETVSIGELIVVKPGEKIPLDG
                     IVTEGESMLDTRALTGESVPRSIRKGEEALSGCVNQSGVLTIKVTKSFGESTVTKIIDL
                     VENASSRKAPTENFITTFARYYTPIVVGMAAILAIIPPVILGGGWSEWLRRGFVFLIVS
                     CPCALVISIPLTFFGGIGAASKRGVLVKGSNYLEALNKVSVVVFDKTGTLTKGVFKVVD
                     ITVEFGFTKEQVLEYAAQAESYSNHPIAKSIQEAFGKTIDQSVLSGYEEISGHGIRVLI
                     GGKRVLAGNSKLMDSEKVSYAACQSAGTKVYIAVDGRYAGCIVIADEVKDDSQNAIASL
                     KKIGVEKTVMLTGDDEKIGKAVAEQLGLDEYYAQLLPDQKVEKLEYLDQHKTKGSKLAF
                     VGDGINDAPVLARADVGIAMGGLGSDAAIEAADVVLMTDEPSKLVDAIDVAKATKRIVM
                     QNIIIALGIKSVFLILGALGIAGMWEAVFGDVGVTIIAVLNAMRILKK"
     CDS             complement(10661..11017)
                     /locus_tag="ctg58_13"
                     /transl_table=11
                     /translation="MADSQFTCNCDVIHEDIVNDVKKKMQSKEEYIELASLFKLFGDGT
                     RVQILHALEQSEMCVCDLAVLLGVTKSAVSHQLKALRLAKLVKYRKEAQIAYYSLADEH
                     VKEIIDKGFEHLRD"
     CDS             11801..12337
                     /locus_tag="ctg58_14"
                     /transl_table=11
                     /translation="MENQLFELARKRRSIRQYGNKRIDDDVIAEIMKVALTAPTSFGHH
                     AVEFVVVREAEMIRKVGACKNFGGSQVNGADTVIVAIVKTSDKRASEFWIEDGAIASAY
                     LLLAIEQYDLGACWVHIRNRKGKLKSSDEEIRQLLNIPDGYTVLNLVALGEKGEKKAPY
                     TEKDLKFGNIHMEKF"
     CDS             complement(12663..13313)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     67.6; E-value: 2.3e-21)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg58_15"
                     /sec_met_domain="LysR_substrate (E-value: 5e-16, bitscore:
                     49.0, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 7.1e-22, bitscore: 67.6,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIMLNHNLRIFIRVAEKGSITETANELYISQPAVSKAIKILEDEL
                     NLKLFHRDKRKGLILTDIGHEILILARQMEKTENRMYQAAFRSNNFIGGKVRIASMPIL
                     TSVILSEVFYRFHKLYPYVSIELIEGSSMDIRKAIEEHQVDLGIFSAPFDTLDYQLLFT
                     DRMIAVGTSEMLTDPVLDLNIEPERFIFCQVGHETAMELLKAKNVKISQSFIV"
     CDS             13411..14349
                     /locus_tag="ctg58_16"
                     /transl_table=11
                     /translation="MSIILGFLAGVGLPIQTSVNTRLRKKVGSPYNASLVSFVVALLFL
                     SALLLITGQGLHIPLAQLLNEPAWIWIGGICGLVFLTGNILLFSKLGGVQTVVLPVLGQ
                     ILMGLIIDNFGLFYSQKTPLSVFRIAGAVMVILGVVLVSMAKENKTASEKLQKSESTTL
                     WIWRAFGIFAGMLSATQIAVNGYLGKVVGSPIKASAISFTVGIIFLAIICIVLHFKNGK
                     SESFKNESAKNPWWMWIGGILGGLYILANVYLSRIVGTGMTVIILLIGSTTGGILVDHF
                     GMFESPKKPINAQKILGVLIMILGAAAIKLL"
     CDS             14364..15014
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg58_17"
                     /sec_met_domain="adh_short (E-value: 8.8e-32, bitscore:
                     100.4, seeds: 44, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKKNIVIAGAGSGMGNHIAEVFGKHGFQVFLLARNRKHLTEYEE
                     QFRDKGIDCFGIVADISETESVRKAFADIFSEINYIDVLVCNVTIREPGLPTSWTDKDL
                     LEHYNTDVLGAFRCVKEVLPSQIAQGIGTILFTGGGFSIHPMAEYSCVSIDKAALRSLA
                     CTLHQELKEKGIFVGIVTIMGNVVPETHYAPEKIAEVYWKMYQERKVWEYIYQ"
     CDS             complement(15301..16461)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg58_18"
                     /sec_met_domain="Amidohydro_1 (E-value: 8.3e-18, bitscore:
                     55.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKLLKNANVYAPEKLGKKDILIEGEKILLMQDSIEGYEGLPGVE
                     TYDLEGKIVVPAYIDMHVHITGGGGEQGPASRVPESQLSEFLKNGITTVVGLLGTDGVT
                     RSVENLVAKARALTEEGMTVYTLTSSYGYPPTTLTGSVERDIILVPPMIGVKVAVSDHR
                     SSNPGGEELIALATAARRAGLLSNTPGLVTMHMGDGEGRLDPVFYVLDHSDVPAKNLLP
                     THILRNPGLIDAGADLVRRGGYIDCTAGADDVEVESDAMKLYELLHREGVKLDHVTISS
                     DAFGSQPRFNEEGECIGLTYASPKYLHRTIQILVREGMPLEAALQLLTSTPAVLLGQEG
                     VKGCVAEGADADLLVLDENLDINSLFARGQVAVWEQEVKMKGRFEQ"
ORIGIN
        1 attcatctca ctacctgcag aggtaggaga attcttgtta tatattatgt taaataaggt
       61 gttgacattt ttcccctcct gcttatatgt ggtttatttt cctgtttttt atttttcctt
      121 aggagtgctt cctgatggtg ttactttaac atttttatgt attttttcca atacatgaaa
      181 ccgccatata atacaacaat cctgccaaaa cctcatttca ctttttaaaa caaaaaaccg
      241 ggatcctttc ggatcccggc catgtatata tggggggaga ataagcaatg gaggtttaac
      301 cttcgattgc gatgtaacca tttttctcaa cggctttcgg tgctttcttc ggaacggaaa
      361 gtttcagaat accgtcttca tatttcgcgt ggatatcttc ctcgctgact gcatcaccaa
      421 catagaagct tctgcttaag gttcctgcat aacgttcacg tctgatgtaa ttgccttctt
      481 tatctttctc atctttgtca agacccttgg ctgctgccag tgtcagataa ccatctttca
      541 gctgaacctt aatctcatct ttcttaaatc ccggaagatc gacatccagt tcatagctgc
      601 cgtctgtttc acggatatct gttttcatca tgttctgtgc atgtttacca taaagcggat
      661 tcttcttgcc ccaaaactca tcgttaaacg ggaagttcat ccaatcatca tcaaataagt
      721 tttctccaaa aatactaggc attaacataa gtcatctctc cttttatgat aaaaaatcta
      781 tatacaagtc tttcgactgt tgcctgcaaa tctatattta agggtactgc ccgaagtctc
      841 cgggcagcac cacgagcttt ttagcggtca gatattgtct gacgggaatc tgatcaaatc
      901 aattactgat tattcaatgg taatatattt cggatcattg gaaactggtt ttgcttcttt
      961 cttcggaaca aacagtttca gaataccgtg tttgtattca cctttgatgt cttcctgtgt
     1021 aacatcttca cctacataaa agcttctctc gcatgctcct gcataacgtt cacgtctgat
     1081 gtaacgtcct gtcttcttgt catcctgttc ttcatcaaga cctttggctg cgctgacggt
     1141 cagataacca tctttcagag ctaccttaac ttcctctttc ttgaatccag gtacatcaat
     1201 taccaattca taaccttcct tggtttcttt gatatctgtt ttcagaagat tctgtgctct
     1261 gtgtccatac agcttcttct ctgctttctt ctcatctttg tcatcgtaat agaacggtgt
     1321 aaagaaatca tcaaataaac tttctccaaa aatactaggc attaacataa gtcatctctc
     1381 ccttttcttt ataatctata tcaactaact tgttaagtac tgaacccggt tggtatggag
     1441 gatatctaag agattttctt tcaatcttct tatctcttta tccctcttcc tttgttctag
     1501 ttgtaatata acacttgttg ttagcactgt caataggtga gtgctaattt tttgtgaaga
     1561 atttgtgaag cctttatttt acgggcttca cagggatttt tcacttgctt tcgcactcga
     1621 ttttcttgat tttacaccat ttttacacca tttcatttga ttttggtgta acactcactt
     1681 tatttacacc aaattacacc atcgacttac atttacacca cagcaggtac agtttccggc
     1741 agattcattt ttgacatctc attttctaca tgagccattt cagcgatatg attgtagata
     1801 ttcatagtga tcttcgcatc agaatgttct tcgctccgct acggtcggtg ctaaacgaat
     1861 gtccactgga catccagcac cccatcacat actgcataac tttgggattg acattattct
     1921 cacccaatct ggtacatcct gtgtgacgaa gaatgtgtgc agatatatga ggcatcagtt
     1981 ctggctccct gttctcattt tccgccaata ttgtttctct cttattatag gcattaacga
     2041 tattcttcag aaaactattc acacctgctg gcataatcgg acgcccatgt tttgtgttaa
     2101 aaataaaacc actgcgttta ccaatctcta cattactctg caatcccaac atcaaattta
     2161 attccttctg cttacgaaac gcatcatata cggtctgagt cataggaatt gttctgattc
     2221 cagcatccgt ttttgtctcc caatcatgga aacaataacc ttcttctccc tcataataaa
     2281 caagctgtcc attcacatga atttcccggt ttttcatatc cacatctgac caggtcaatc
     2341 cgattgtttc acttattctc aggcaggctc caaacataat ctgcatcatt ggcaaatgcg
     2401 gcttatacac cttactgttc tccacaaatt tcagaagctt ctcttgttgt tccagcgtta
     2461 atgcctcttt ctcctttgca gcagcaccat aatcgccaag agttcctgtt accggatttt
     2521 tacggataat cccatcctcc acagccatat taaatgctgg gtttaataaa gcatacatac
     2581 ttttaatcgt gctgtgtgcc aaaccctcat ccgaaagtcc tgaaaaaaat gtccgtacat
     2641 gagatgtctt aaaatcaact acacggatgt ttccaagagt attctttatc cgataattcc
     2701 atgttcgcca gtagtccttt ttcgtttttt cccggatatt ctttgtcgcc atatatcgct
     2761 caaataatcc atttaccgtc aatttcttta cagatgtgtc cgtaataagc tgatcgtcaa
     2821 tatctttatt gattttcttt tcctgctcac gcagacttgc cagatccatg tcatagattg
     2881 taacacgctt tccggtaagc tcatctttgt aacgatacat ataacgtccg tctggacgct
     2941 gactttctcc agtttttaaa tttctgcctt tattgtcttt tcttgccata ctaatcattc
     3001 ctttcacatt cgttgtttgt tattcggaat gatttttgtc ctgttcgtat cagtcataat
     3061 ctgtctgata tctgctcaca gattaacata atattttagg atttccaagg gtaaattctt
     3121 gaaaaacacc aatttttctt tgcactctca ttccgaagga aattcgttgt tttctcctgt
     3181 tctcgtccat tacactgcca ttgcatcaag atattttttt atcttatcca cgttatagag
     3241 aacacgtctg ccaacaatga tctttgcttc tgcacagtct gcgatttttc ttgctgtgac
     3301 tgcaccgcag gatagcattg ccattaaacc ttcaatatcc acagtcagac gattttctgt
     3361 gttatactct gttgtctttc tcatgatgca catacctcct ttcctccgta ttcttctgca
     3421 tcacctccca gacatcggtt tcatgcccgt tgtcagtacc ttcttctgtc gttttcgatg
     3481 ttgtctaatg atgaattttc ttctgttcgg cgtgttggct tccattcgta caggcggtgt
     3541 caacgttaca tttgacctct atcagaattt ttctgaatgc tgccagctcc ttctcgagcc
     3601 tgccagccgt tgccggagta tcttcgactt ccacatgcta ctctctggta cagcggtgga
     3661 attctgtgtt gtcctttaat cctctaaggg cacctataca gctcattcaa ttttcaaggt
     3721 gcggaaaagc tcttgaattc ctattcaaaa cctttttcta ctaatcacac atggcagagg
     3781 cgataaggtc atatttttca taaaaaattt gatttttttc atctcagcct tgtccattcg
     3841 cttttatgcg aatattgatt atactgtcat tatatttcgc tttaatgtta atgtcaagtt
     3901 tttttattcg ctcaaatgcg aatgtttctg tttacatttt gagattttga tagtaaaatg
     3961 gaattatcaa atagaaagca ggaaatctga tatgacgatt ggtgataaaa taaaaaaaat
     4021 ccggacattc cggaatatga cacaggcaga actcggtgca gctctcggct ggggcgataa
     4081 aggtgcaaat cgccttgctc aatacgaaac caactaccgg gttccccgta aagatctggt
     4141 tactgaaatg gctaaaattc tcgatgtgaa cccaattgct ctgtatgaac caactataat
     4201 gaatgccgaa gaattaatgg aaacactttt ttggattgat gaatttaatc ccggtatgat
     4261 caaactattt caattagaga cttatcccgg tgaaaaatgc aattccagtg aagataccgc
     4321 cgtccgctat catgactctg acgactggcc agtccatcca cctgttggca tgtggtttaa
     4381 ttatggggtt ctcaatgatt ttttgaaaga atggactctt agaaaagaag aactgaaatc
     4441 tggcgtgatt accagagatg aatattttga gtggaaaatc aactggccac aaacctgtga
     4501 tgactgtgga aaatatgaac cccaaaagca ttggaaaaaa tcataattta tctgtactca
     4561 ccgtacactc gaaataaaaa agagatgcca gtaatatact gatatctctt tttctctact
     4621 ataattttgt atgatagagc atgtcttcca tgtagaagat taaactagaa aaacttccag
     4681 ctctttttaa tcatttcttc cacacagcgg ctgcatttga ccttaccata agctcctcca
     4741 ccggaatccc tgccggacat atattctggc atgatagtga tttcccacat ccttcaaaat
     4801 aatgtttcct atatttctct gctatttgtt catggtgtga agtatcctgc tcctcattca
     4861 gtatcctgta tgcgtttacc ggagcaatgg cacctgcgaa gtctttccca aaatcaaaat
     4921 tcggacagac ctcaagacaa catccacaca taagacatct tgctgattga tagcgtatct
     4981 catgagtata ctctgtcata tatgcatcgc tttcaagcca caggttgatc ttcttaagat
     5041 tttcaaaaac aactgacctg tcaacgatca gatcttttac taccggaaat ttactcaaag
     5101 gttccagtac aattactttt ccctttagag attgcaaaaa tgtagaacag gcaagttctg
     5161 gcagaccatt gattcgcatc gcacatgccc cgcatttttt caccatacag ccgcattccc
     5221 atgaaatcgg ttcagcttct ttgcctgatt tatcagtaag tttctgtctt gcattcagtt
     5281 cattcagcat agctgcaatg gaaagctcac cctctgcttc tatttcaaat tcctgccaga
     5341 aaggctttgc ttctttattt tcctgacgct ttatacgaat ggtatatctc atttttactg
     5401 ccgcctttcc ggaatttctt caaaatgtat ctgtatcttt tgtccattat agcttgcaat
     5461 ggttgttctt gcaaaatcat catttttctt cggatagtct tctctgtagt gtgcacctct
     5521 gctctctgtt ctttcgatgg cactcatgat tgcagcctgt cccagcagtg aaagtgagcc
     5581 ttttatttgg catagcttct ccagttcttc ttccatgcgt ttccgatttc ttacaactcc
     5641 aagtgtattt agcatgattt tatttatttt cttcttatca ggctggctga tggattcaca
     5701 caaatctgcc agctcttgcg tctctgttac cagcatatcc ttagctgtca ttgcatcctc
     5761 gcaggcagtc tgtgctgcaa ttctgccacc atagattgct ccaagcaaag aattaccacc
     5821 aagacgattt gctccatgat actgtgcaca gcactctccg gcagcatata gatttctgac
     5881 aggtgtacga tgcttctcgt ccacgtaaat accacccata aaataatgga tacccggcac
     5941 aacctgtacc ggctcttttc tgatatcctt atgaagataa atctgacaat ccgataccag
     6001 ccccgcaagt ttcctgtctg tcacatcttt aggtatctct gtcatatcca gataaacagg
     6061 actttcctta cttattttcc atatttctct tgcagtgatg tctcttggca tcagattgcc
     6121 aagttccgga tatttttctt ccataaaata ccatcggttt ccatccctgt atgtgaaaag
     6181 gcgaccacct tctcctctgg cagcttcgct gatcagcatt ttctttccgc caatctcaac
     6241 tgttgtcgga tgatactgga tcatctcaag attagccata ggaacacctg ccgaaaacag
     6301 gctggcactt acttcaccgg tatttgctaa ggaacctgtc gtatttccaa acagtccatg
     6361 cataccaccg gaagccacga taactgcatc cgcatatagc atttttatct cacctgtata
     6421 gttatcgcag acaacacatc catgacatat gttcgctgtc atcagtaaag tacggaagga
     6481 gtgatgttca aaacgctcta tctgtccctg cacttctaat cgccgtactg catctatcat
     6541 agctgtcatg atctgttttc cggtatcact ctttgcaaac gctgtccgtt tctttttctg
     6601 tcccccgaaa tttctcagat ccagttcatc ataaccacat gtattaaact gcactccgat
     6661 gctgtgaagc cactttacca cttccggtgc cgcctgtgtc atattccaga ctgcgtttgg
     6721 atctgccaga ttgcatccgg cttttatcgt atcttcgtaa tgttcctgtg tactgtcatc
     6781 ttctcccttg gtattaagtg cggcgttgat accgccctct gccataactg actgtgctct
     6841 ctcagaaggc agagaagaga ttaactttac actgcatcct tcttttactg cctgcaaagc
     6901 tgccgacaga ccggcaagcc ctgctccgac aataatcata ttctttttca taatgtatgc
     6961 catcctatat agtaaatgat aactgcccct gcactaaaca gcagcagaac cgacaatatc
     7021 agataaatgt ctcctcttct ctccttatag cttatgattc caagcgatac aagcagtgga
     7081 cggatattta taaaaagatg aataaaaagt gctgcaacca gtaacagctg cgtaatgagt
     7141 tttactgttg taaacggaaa caaaatatag atcccgtcct gtactccgcc aaataatcct
     7201 atatggaaaa acatcagaat aagtattgca agtccgctgg ctctccttgc ccagaatact
     7261 gcattttgtt ttaagtagct gttacctgca tttttagaaa ttttcaaagt atttatggta
     7321 agtatgactc caatcacagt atgtgctgca agaacagcca ctccaaccca cgcaagtatt
     7381 ttcccggcac tgcttccaat tccaagaagc ataaaacttc ccataagacc atgcagcata
     7441 aaaatcacga gcagtaatac ggaaagtatt gtatttattt ttctcattct tccgctcacc
     7501 tcatttctgc actgtccagt atgatatagt cagcattttc aagagcgtct gtgctgacca
     7561 gatcactttc agaaaggaat gcttcatatt tcccactgac tgcccttgaa cgcagcattg
     7621 taccgctgta ttgttttatc tgcacatcag cacctgcatc attaagcctt tcgcataagg
     7681 aatcggcata tcttataagc gcataatctg tttccgaaac ataaatatca aatgataatt
     7741 ctgtatctgt acgaatgcta tccgtctttc ctgttacaaa tgcttttaat tgctctctta
     7801 tatcctcatc tgacagttta tcaagcaacg gattcataca gaaaatataa ctgccctcaa
     7861 gctgtgccga gctttgggct gctttctttg cctttggtgt tgcacctgta acagcatcta
     7921 taatggatgg aggggagtgc agtaatgcac caaaccctgc aatcaaagca attaccacca
     7981 ccagtaaaat aagtctacgc ttcactgcac ttttctcctt tattttttca aaatcctcat
     8041 ggcattcaat actgctataa tcgtaacacc aacatcacca aatacagctt cccacatgcc
     8101 tgctatgcct aatgcaccca gtataaggaa cacactcttg attccgagtg caatgataat
     8161 attctgcata acaattcttt tcgttgcttt tgcaacatca atcgcatcca caagctttga
     8221 tggttcatct gtcatcagaa caacatctgc agcttcaatc gcagcatctg aaccaagtcc
     8281 acccatcgca attcctacat cggctcttgc aagaacaggt gcatcattga taccatctcc
     8341 tacaaatgca agtttgcttc cttttgtctt atgctgatcc aggtactcca gtttttcaac
     8401 tttctgatct ggaagtaact gtgcataata ttcatccagt ccgagctgct ctgccacagc
     8461 ctttccaatc ttttcatcat caccggtaag cataactgtt ttctcaacac cgattttctt
     8521 cagactggca atcgcattct gactgtcatc tttcacttca tcggctatta cgatacatcc
     8581 ggcatatctg ccatcaacag caatataaac ctttgttccg gctgactggc aggctgcata
     8641 agatactttc tcagaatcca taagtttgct gtttcctgca agtactcttt taccaccaat
     8701 caatacacga attccatgtc ctgatatttc ttcataaccg gaaagaacag actgatcaat
     8761 tgttttgccg aaagcctcct gtatggattt tgctatcgga tggtttgaat agctttctgc
     8821 ctgtgcagca tattcaagaa cctgctcttt tgtaaagccg aattctactg tgatatcaac
     8881 aaccttaaac acaccttttg tcagggttcc agttttatca aacacgacga cgcttacctt
     8941 attcagtgct tctagataat tgcttccctt tacaagcaca cctctctttg atgccgcacc
     9001 aattccacca aagaaggtca gagggatgga aataaccaat gcacaagggc atgaaacgat
     9061 taagaataca aaacctctgc gaagccattc tgaccatcca ccaccaagaa tgacaggcgg
     9121 aataatagca agaatagcag ccatgccaac aacaatcggt gtataataac gtgcaaatgt
     9181 tgtgataaag ttctccgtag gtgcttttct ggaagaagca ttttcaacca gatctataat
     9241 ctttgtaact gttgattctc caaaactctt tgtaacttta attgtaagaa caccgctctg
     9301 attgacacat cctgacagtg cttcttctcc cttacggatg cttcttggaa cagattcacc
     9361 ggtaagtgct cttgtatcaa gcattgactc accctctgta acaattccat ccaaaggaat
     9421 cttttctccc ggttttacaa caatcagttc gccaatcgaa acagtttccg gtgctactac
     9481 taccagttcg ccatttcttc tgactgtagc cgaatccggt ctgatgtcca taagatcaga
     9541 aattgatttt ctggaacgct ttacagcaag tgactggaaa aactcaccaa cctgataaaa
     9601 gagcataact gctacagctt ctggatactc cccgattgca aatgcaccta ttgtagataa
     9661 actcatcagg aaatgctcat caaaaatctg tcctctggta atatttttta ctgcctgcca
     9721 tacgacatcc cagccaagaa taatatatgc aacaatcaat acaccaagtt ctacaggaag
     9781 cgatacatgt ccaaataagg tcaatcccat tccaaccgca tagatgactg cacctgagat
     9841 cagacgtatt gtaagctttt tatcatcatc actatatacc ggtgttttct ctttcttatc
     9901 tggagcaaca gatgtatctg ccttttgttc tgatacttca acatccggtt catggctgtg
     9961 tacaatcgta gtaaccatat ccagcatgga agctgccttg ttatgatcca tactgacagt
    10021 aagtgtctgc ttcatcagat taacctcaga taaagctact ccttccagtt cgccgacttc
    10081 cttttcaatc tttgctgaac aattgggaca atccagtcct tttaacaaat attttttagt
    10141 aacatatgaa tccgtttgct ctgaaacttt aacatctggc tcatgactgt gtacaatagt
    10201 cgccacttca tcctgtatct tcccagaagc agaggtcttc acacttatag taagtgtctg
    10261 tttcatcaga ttgactactg atgatgatac atcctctaaa tcaccgactt ccttttcaat
    10321 ctttgctgaa cagtttggac aatcaagtcc ttttaaaaga tatgttttag tagtatacga
    10381 ctcttttttc tcagatactt caacatccgg ttcatggctg tgtacaatcg tctcaatctg
    10441 ctcaacgatt gaattgtcga atgtttcagt ttgtattgta agagtctgtt tcatcagatt
    10501 gacagatgat gaattcacat tctctaaatc gccaacttct ttttcaatct ttgccgaaca
    10561 attgggacaa tccagtccct tcagtaaaaa tattcgttcc attctaacct ccattgtata
    10621 tgtttagttg ctcaatcact caacttaaaa ggtaaaaatt ttaatctctt aaatgttcaa
    10681 agcctttatc aataatttcc ttaacatgct catctgccaa agaataatac gcaatctgag
    10741 cttccttacg atattttact aacttagcca gacgtagtgc cttaagctgg tgcgatactg
    10801 cggatttcgt aactccaagc aatactgcca gatcacagac gcacatctcg ctttgttcta
    10861 atgcatgaag aatctgcacc ctggtaccat ccccaaataa tttaaaaagt gaagcaagtt
    10921 ctatatattc ctctttagac tgcatcttct tttttacatc atttacgatg tcttcatgga
    10981 taacgtcaca attacaagtg aattgagaat ctgccattat cttcctcctt atgctttagt
    11041 tgaacaactg ctcaactaat tataatatgt tattttttca ctgtcaataa aatttaacct
    11101 gaattattca tttttttatc aatgtatcct ttttccagaa gtggtgcctg atacagcttc
    11161 cggcagatga ataccatatt agcttcttta aaatatgtag ttccatctga aaatacaggt
    11221 gtcagaccgg tagcttgtat cttatcctca tttttccctg aatgactccc aagatagcct
    11281 aatgtttttt atattcagcc ggaaagtggg ataatgtaaa atattcttcc taatccattc
    11341 gcagcatatc aggaaccagt aaaatcccga ttactgtaaa cgcaatacca cctgcacata
    11401 ccaacactat tgtcgtttca attccctttc ttacttttct cctgtctttt taagcacagg
    11461 aagattcgga aatctccctg tgtttttctt aataatatcc tcgttcttcc agccagtctt
    11521 tcacgtaact tctgattcaa aaataaattt tttataagat aaatttattt ttctttttac
    11581 tcaaatacat tcttagaaaa atagccccca tatttataag gaaaatcaaa aaaatcaaat
    11641 ttaacgatag atactctcgc accatatttc ccagcactgc actaaaggaa atggatgcat
    11701 ggaatgcact acttgcaaat gaataccata cacagcttgg aaacgaagcc ggtgagtatt
    11761 tcgatgtcaa tgggtttatt gcagttcagg tagaagtata atggaaaatc agttatttga
    11821 actcgcaaga aaacgacgtt ctatcagaca gtatggaaat aaacggattg acgatgatgt
    11881 gattgcggaa attatgaaag tagcattaac tgccccgact tcatttggac atcatgcagt
    11941 ggaatttgta gttgttcgtg aagctgaaat gatacgaaaa gttggtgcat gtaagaactt
    12001 tggcggttct caggtaaatg gtgcagatac tgttattgta gccatcgtaa aaacgtcaga
    12061 taaaagagcc agtgagtttt ggattgaaga tggtgctatc gcatcggcat atctgcttct
    12121 tgcgattgag caatatgatc ttggagcctg ctgggtacat atccgtaacc gaaaaggaaa
    12181 attgaagtct tctgatgagg aaataaggca gttgttgaat attccagatg gatatacagt
    12241 attaaactta gtagcacttg gagaaaaagg agaaaaaaag gctccttata cagaaaaaga
    12301 tctaaagttt ggaaatattc acatggaaaa attttaaaag acacaataaa gggatatatg
    12361 ataatagccg gttatggtta tcatatatcc cgctttttat cgctatgtat ttataaaaaa
    12421 ttgtgagtaa caggttatac agatggaatg atttcactta cataattcgc aatcatacgt
    12481 tttagttcca gagcaaccgg agtcagatcg tgcagatcat tcgcagcaag cccgatagga
    12541 atctctattg tcggttcaat cgcacaacgg cttagtttat ttggggtatt gtttactgta
    12601 aactctgaga tgataccgat gccatttcct ttttctgcga gatgaatgac cgattccgcc
    12661 tgttagacaa taaagctttg tgatattttt acattttttg ctttgagaag ttccattgca
    12721 gtttcgtgtc ctacctgaca gaaaatgaaa cgttctggtt cgatattcag atccaagacg
    12781 ggatctgtaa gcatctcaga agttccaaca gcaatcatac ggtctgtgaa aagaagctga
    12841 taatctaacg tatcaaatgg tgccgaaaag ataccgagat caacctgatg ttcttcgatt
    12901 gccttacgga tatccataga acttccctcg atcagttcaa tcgacacata aggatataac
    12961 ttatgaaagc gataaaaaac ttcagacaat attacagagg tgagaattgg catagatgct
    13021 attcttacct taccgccaat aaaattgtta gaacggaaag ctgcctgata catccggttt
    13081 tcagtttttt ccatttgacg ggctaaaata agaatctcat gccctatatc agtaaggata
    13141 agaccttttc ttttatcccg gtgaaataat ttcaaattta gttcatcttc caatatcttg
    13201 atcgccttgc tgactgcagg ctgggagata taaagttcat tggcagtttc agtgatgctt
    13261 cccttttcgg caacccggat aaagatacga agattgtgat ttaacataat catatagtta
    13321 tctccacatt tcaataacgg tatttgagtt atgaacaagt ataacataca ataaaaacgt
    13381 gaacaagaga tatagaaagg aatgaagaat atgtcaatta ttttaggatt tctggcaggt
    13441 gttggtctgc ctatacaaac aagtgtaaat acaagattaa gaaaaaaagt gggttcacca
    13501 tataacgcat ccttagtatc atttgtggtt gcgttattgt ttctatccgc attattattg
    13561 attaccggac aggggttaca catacctttg gcacagttgt tgaatgagcc tgcatggatt
    13621 tggattggcg gtatctgtgg tctggtcttt ctgacaggaa atatcttatt attttcaaaa
    13681 ttaggtggag tacagacagt tgtacttccg gttctcggtc agattttaat gggcttgatc
    13741 atcgacaatt ttggattgtt ttattcacag aaaacaccgc tgtctgtatt ccgcattgct
    13801 ggtgcggtaa tggtaatttt gggcgtagtt ttggtttcaa tggcaaaaga aaataaaact
    13861 gccagtgaga agctgcaaaa atcagaaagt accactttgt ggatatggag agcatttggc
    13921 atttttgcag gaatgttaag tgccactcag attgcggtaa acggttatct tggcaaagta
    13981 gtaggttctc cgataaaagc atctgctatt tcgtttactg ttggaattat ctttctggca
    14041 attatatgta ttgttctgca ttttaaaaat gggaaatcag aatcattcaa aaatgaatcg
    14101 gctaaaaatc cctggtggat gtggatcggt ggaatccttg gcggattata tattcttgca
    14161 aatgtctatt tatcaagaat tgtaggaact ggaatgacag tcatcattct tttgattggt
    14221 tctacaacag gaggtattct ggtcgatcat tttgggatgt ttgaatctcc gaaaaagcca
    14281 attaacgccc agaaaatact gggtgtcctg attatgatct taggagctgc tgcaattaaa
    14341 ctgctgtaaa ggagtccatt gaaatgcgaa aaaagaatat tgtaattgca ggagcaggat
    14401 cgggaatggg aaatcatatc gcagaagtgt ttggcaaaca tggttttcaa gtatttctac
    14461 ttgcaagaaa cagaaaacac cttacagaat atgaagaaca gtttcgggat aagggaatag
    14521 attgctttgg cattgttgct gatatttcag agacagaatc tgtaagaaag gcatttgctg
    14581 atatattcag tgaaataaac tatattgatg ttctggtatg taatgtaaca ataagagaac
    14641 caggactgcc aacatcatgg actgataaag atttgcttga acattacaat acggatgttc
    14701 ttggggcatt tcgatgtgta aaagaggtac taccctctca aatcgcacag ggtatcggta
    14761 caattctttt taccggcggt ggcttctcca tacatccaat ggcagaatat tcctgcgtat
    14821 ccatagataa agctgcactt agaagtcttg cctgcacatt gcatcaggaa ttaaaagaaa
    14881 aaggaatttt tgttggaatt gtaactatca tgggtaatgt cgtcccggaa actcactatg
    14941 caccggaaaa aatagcagaa gtgtattgga aaatgtatca ggaacggaag gtttgggaat
    15001 atatttatca gtgaatctga gattgtagtt attgaataag cgttaaataa cgcctgtatc
    15061 ttagcctaac aagatacagg cgttgttctt tccggggtca acagttttgt ccatttttga
    15121 cgataatcat attctctcat atttttttac ccatcttcta tgattctggt tttcatctgt
    15181 atttcattat atcttttaat cgtatcatcg tcaatttaat tatatcagaa taaataaaaa
    15241 gaagcgaaaa cctatcaacc atgatggtct tcgcttcttt caattcatat cataaaaaca
    15301 ttactgctca aatctgcctt tcatcttcac ttcctgctcc cacacagcca cctggccacg
    15361 ggcaaacagg ctgttgatgt cgagattttc atccagtacc agaagatctg cgtctgcgcc
    15421 ctctgctaca cagcccttga ctccttcctg accaaggagc actgccggag tgctggtcag
    15481 aagctgtaag gcagcctcca gcggcatacc ctctcttacc aggatctgaa tggtgcggtg
    15541 cagatacttc ggagatgcgt atgtcaggcc gatgcactcg ccctcctcgt tgaagcgtgg
    15601 ctggcttccg aatgcgtcac tggatatggt gacatgatcc agtttcacgc cttcgcggtg
    15661 taagagctcg taaagcttca tggcatcaga ttctacttct acatcatcgg caccggcggt
    15721 gcagtcaatg taaccgccgc ggcgtaccag atccgcaccg gcatcaatca ggcccggatt
    15781 acgtaaaata tgggtcggta gcaggttctt ggccggaaca tcggaatgat ccagaacata
    15841 gaataccgga tccagtcttc cctctccgtc acccatatgc atagtcacca gccccggtgt
    15901 gttgctgagc agaccggctc tgcgggctgc ggtagccagg gcgatcagct cttccccgcc
    15961 cggattggag cttctgtggt cagatacagc taccttcaca ccgatcatag gcggaaccag
    16021 gatgatatcg cgctctacgc ttccggtcag ggtggtcggc gggtaaccgt aggagctggt
    16081 cagtgtatac acggtcatgc cttcctcggt cagggcacgg gcctttgcta ccagattctc
    16141 tacactgcgg gttacgccat ctgtacccag aaggccaacc acggtggtaa taccgttttt
    16201 taaaaattcg ctgagctgag actccggtac acgggatgcc ggtccctgct ctccaccgcc
    16261 tccggtgata tgcacatgca tgtcaatgta agccggaaca acgatttttc cctccaggtc
    16321 ataagtctcc actcccggga gtccctcata gccttcgata gaatcctgca tcagaaggat
    16381 tttctctccc tcaatgagga tatctttttt tcccaatttc tctggtgcgt aaacattcgc
    16441 gtttttcagt aacttgatca taatgtctat tctcctgcct tttctttatt cttcaaaaat
    16501 tccaccggaa tcaggaatcc cggtggaaca agactttcgt atttagttct cctttttctt
    16561 ctcatcagca agctttgcga taccgaatcc ggtaaagccc cagatgattg caaagatcca
    16621 gccagtgtag cacaggattg cccacggaag gtaatccagg gtctctacac caagggtaga
    16681 tgccatatag gcacctgctg cggaccacgg aatcagcggc accactacag taccggcatc
    16741 ctcaagggtt ctggacaggt tctttgccgc aagtccgcgc tctttataag cgtcacggaa
    16801 catctctcca ggaatcaaaa tggaaagata agagttaccg gtagtcagtg ccatggtaat
    16861 gcaggctgcc accgttgcgg taatcagtgc gccggtactc tttgccacgc ttaaaatctt
    16921 ctgaagtaca acatccagac agccggcccg g
//
