LOCUS       c00034_gnlPro..        14143 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DBFMDGLB_34.
ACCESSION   c00034_gnlPro..
VERSION     c00034_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 21:03:01
            Original ID  :: gnl|Prokka|DBFMDGLB_34
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14143
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14143
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2175:5424]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2176..5424
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..14143
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14143
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             716..2173
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_1"
                     /sec_met_domain="OKR_DC_1_C (E-value: 2.3e-14, bitscore:
                     43.2, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 5e-127,
                     bitscore: 413.0, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYERQQHAPIYEALERFRKKRVVPFDVPGHKRGRGNPELAQLLG
                     EKCVGLDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSAVQSMILSVC
                     KAGDKIILPRNVHKSAINALVLCGAIPVYVNPEVNAQLGISLGMEVSQVEKAMDENPDA
                     VAVLVNNPTYYGICSDLRTIVKKAHARGMKVLADEAHGTHLYFGRNLPVSGMAAGADMA
                     AVSMHKSGGSLTQSSLLLLNKSMNAEKVRQIINLTQTTSASYLLLSSLDISRRNLALRG
                     EESFEKVAGMAQYAREEINEIGGYYAYGMDLINGTSVFDFDVTKLSIYTLGNGLAGIEV
                     YDLLRDEYDIQIEFGDICNILAYISIGDRLQDIERLVGALADIERLYKKDSTGMLSGEY
                     IAPAVVASPQQAFYAEKESLPMEQAAGRISGEFVMCYPPGIPILAPGEMVTQEIVEYIL
                     YARDKGCSMQGMEDPKVERLQVLKGGI"
     CDS             2176..3036
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_2"
                     /sec_met_domain="Spermine_synth (E-value: 1.1e-53,
                     bitscore: 170.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 4.2e-16,
                     bitscore: 48.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFV
                     ALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDV
                     VESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKTRYDLIINDSTDPLGHT
                     EGLFTKEFYGSCYTALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHI
                     PTCPSGYWLFGFASKKYHPLEDFRPERFDNLNIETWYYTTNLHRGAFMLPKYVEDLLEE
                     EENSL"
     CDS             3033..4313
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_3"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 9.9e-44, bitscore:
                     139.6, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 1.6e-36,
                     bitscore: 114.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLLVIGCGGVASVAIRKCCQNSDVFTEIMIASRTKEKCDALKE
                     KIESTTKTKIETAKVDADNAAEVAELIRAYKPDAVLNVALPYQDLTIMDACLEAGADYI
                     DTANYEAEDTEDPTWRAIYEKRCKEKGFTAYFDYSWQWAYDEKFKEAGLTALLGTGFDP
                     GVTSVFSAYALKHYFDEIHTIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWEDGH
                     WVETEPMEFKSVYDFPEVGKKDMYLLHHEEIESLAKNIPGVQRIRFFMTFGQSYLTHMK
                     CLENVGMLSTAPVEFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGIKDGKEK
                     SIYIYNVCDHQECYKEVESQAISYTTGVPAMIGSMMVVTGQWKKPGVFNVEEFDPDPYM
                     EALNKWGLPWKVCEDPELVKVWKANED"
     CDS             4303..5424
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_4"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 2.4e-15,
                     bitscore: 45.9, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDQLQTPCYVIDEKKMRENLEILKKVQEDTGCKILLAQKAFSG
                     FALYPMIGKYLAGTTASGLFEARLGYEEMGKENHVFSPAYRTEDIEELDRICDHIIFNS
                     TAQLKKFKEVCTGASLGLRINPECSTQGDHAIYDPCAPGSRLGVTRENFDVECLKWIDG
                     LHFHTLCEQNADDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYDVKLLEKCIQH
                     MKETYDLDIYLEPGEAVALNAGYLVTEVMDIVENGIRTLILDASAACHMPDVLEMPYRP
                     PLKDSGEAGEKAYTYRLSSCTCLAGDVIGDYSFDREIRIGDKLYFMDMAIYSMVKNNTF
                     NGMPLPDIAVMHEDGECEVIRHFGYEDFKSRLS"
     CDS             5372..6583
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_5"
                     /sec_met_domain="PAD_porph (E-value: 7.2e-129, bitscore:
                     418.8, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VRLSDISDTKTLRAGFPDICRAIKEKETDMEVTEKNRTKYRMPGE
                     FEPHEGCVMIWPERPGSWNYGAREAQKAFVKVAEAIGESEKVYMLVSKAQMENAKNQLG
                     NVSGVTLLECETDDAWARDVGATMVLDEKGAVCGVDWQFNAWGGDFDGLYRNWEKDDRV
                     AAFICRTLGCPCLDARPFVLEGGSIHSDGEGTLIVTEACLLSQGRNPQMSREQIEEQLK
                     YWLGVHKIIWLPCGIYQDETNEHVDNVCAFVRPGEVVLAWTEDETDPQYAMSLADLKVL
                     EQETDAKGRKFKIHKLPIPQKPVCLTREDVDGFVFEEGEDEREAGERMAASYVNFYISN
                     GGIILPQFGDENDKRAVEILQKCFPERRIYPIDARAIIVGGGNIHCITQQIPGKISDLD
                     AEKL"
     CDS             6664..7542
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_6"
                     /sec_met_domain="CN_hydrolase (E-value: 9.8e-57, bitscore:
                     181.4, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNVTVAAVQMKCSKSVEKNIAHAEELVRQAAAKGAEIVLLPELF
                     ERPYFCQERRYEYYEYAQTAEENPAVRHFSRVAAELGIVIPVSFYEKEVNNTYNSVAVL
                     DADGKNLGIYRKTHIPDDHYYQEKFYFTPGDTGFKVFDTRFGTIGVGICWDQWFPETAR
                     CMALQGAELLFYPTAIGSEPILECDSMEHWRRCMQGHAASNLIPVIAANRIGEETVEPC
                     PENGMQKSALNFYGSSFITDNTGALCAELPGGEEGVLVSTFDLDALKADRLNWGLFRDR
                     RPEMYAKIVGK"
     CDS             7770..8231
                     /locus_tag="ctg34_7"
                     /transl_table=11
                     /translation="MNRKEFLEILRSQLAGQMQEGKAAAHIRYYEDYIQSQVRGGRSEQ
                     EVLQELGDPHLIAKTLIDTDDGSTQEDYGEYSSYGSSYGNETELPHQQEKRWKKVIDLS
                     TWHGRAVVIAAAAVIIVLLILIIGVAIPFFIILAIILYFLSWLKKRNDQ"
     CDS             8434..13143
                     /locus_tag="ctg34_8"
                     /transl_table=11
                     /translation="MKHNFKLKQRLGALLLAMLFILQAILGLVPVCVTQAAPLTVETWD
                     SDKVVDYGYRFNMKFQPGITTYESFGCDNLDREAFSDNGKSERDTECVRVGADYKAGSA
                     GMRYNNVGKDGNGNIVDVRLILVGVENAEPRYDLRTAESIVQNKGGATFAWKDNEAYPM
                     VGFSKNSIGVFIYSVGYAKVKFQFLKHGTEETLPISGHGTIRDIDAGQGVRIPSDSSLD
                     NAYVLKNNDYLTVDGNSVSSPLGSVEPDDPRGWLNLFYNTDNFTVEFCHQFRLDKWDKS
                     REDAIAKAGSQERWAEITRNKYLDPSGNSYCPNFKGQKYCKAYAYFDFTSYCFGDVEMK
                     KAPEKRVGEANCTWEQAAATSKEKPFGIRQGQEFQYMIRAEVTPNRLKSFVVQDILEDC
                     LTIEDASKVSIVNDAGQTVTDWFDVAVEGQKVTCRAKAESLQDEAFTDNQTYTFTLKVR
                     QRPESEINISKYLAEDGYSILVPNHASMSYERTNGSGDTMDTETVWVKGVIPPELEVKK
                     NTSQYEWKTGDIIDYEVLVSQTKQDVKAVNVVITDELPSCLQLLEGQYAVETSQGGENC
                     TLTGQGENGWKAECPSLKYGETITIRFKCQASADSNGQEWENIVTATADNLINPETGEQ
                     ESRKDMAEVWPNSPQLEIDKTADKYEWQAGEQVAYRIVVNNVTAGTIAKDVTITDIGLP
                     QGLVLAGGAQSMEVLGVQQQVNYPVPDKKTGQAYEARPVDSQLNADENGFSFYCSYVPY
                     SQPVTIIFHCIAQEEANGHESVNAATVKAANTDERSDDAEVYVNSGEFWIEKSADHYEW
                     QVGEQVQYNVVVENKKAGTVARNVTVWDTGMPAGLALSSAEDVSVSGIPQNITQLTAGS
                     KDVLNQLNPEFYNETSEKPVNYEFLQEGSGWRLNISDLPANTPVMISFLCTVTEAANGM
                     ESINVANVQAQNAPVSQDDAEVYVNTAVLSIEKSFQNPYLAAGDGRAENEFRVGEQVNY
                     QVTVNNLQKGSIARNLVISDLSLPEGLALDGAEDAVTVSGVPAVVQNPVAGTDDAGNQL
                     NPENYKETVEKPVSCQVTRQGTGWIVTISDLPYQTPVTVNFRCTAQESVNGMEIVNTAQ
                     AYADNAQKVKDSSKIWVNSPVLKVEKTTDKPFYKYGDIITYRIVLTQEQTGCVARNVTL
                     QDVIDTQGVRLLKDSVILMDEKGNVADADVQINDDNTFLMSTGRTLVRDSRYSICDNDK
                     GGLFEQIMYNPLDCQEQKSMIVEYQAAVIDAALAGQKVHNTAVADSSEKIPATGETETE
                     VHSPILEIVKESDKKEYASGEKGYYKLTVRQLREDVTDQNIVIEDKLETQGASIVKDSI
                     FVKKNGIELKDAKIEADDTGFVIQTGASLSDMDKIEVCYEMVFKTESTEPEKIVNTAKA
                     RGDISPEITAQQEAYVKAKAEPTATPTPSATPKPTETPKPTETPKPTEVPKPTEQPKAT
                     PTPSVPGTCPKMTPVPTKAPLASYNGGNNGGTTSGSGGSSYANSGGYSGGYGSYQGGSM
                     AGSSKTGDVRPFKMMAVLGLIGMGLLTGGVVIYRRTVSGKRNIKGMPRK"
     CDS             13140..14027
                     /locus_tag="ctg34_9"
                     /transl_table=11
                     /translation="MKKLRTFAVSMIIAAIGLLIYCAGFYIKSYEQNLAARQEYAELSQ
                     MAGVKNREGAGLLADGKKTDEDSSTKNSEKKRRKKQRRSSESKNKNCTDEIRESFGISW
                     ENLRKINSQTVAWITVPGADISYPVVQAADDEYYLKHNFRGEEDLFGCIFLEHDIKKNF
                     TDSHSILYGHNIEGNMMFANLNRYEQPEFLKKCPEIEITTPKRKFLYKIFSVEQASSQS
                     PAFEYGYKLSSPAYRRQLSILKNNSMYDTGVEPDERERMVTLITCNSRLDKEIRMAVHG
                     ICHECYGIEKAEPK"
ORIGIN
        1 caagaaattg ttaaacaata gacatagttg tccctgataa atgaagaaaa tataaaaagc
       61 gggtaaagac tgtgcaaaat atggaaaatg gaattgacaa cagttcagaa gatatgttat
      121 tctcatcttt agtatgaaaa gacactatcg ttttcatgca aatatttgct cacattcaga
      181 gacagtttct gaatgttaag ccatacggac aggcggggca gttgccgggt gggagacacc
      241 acattattga ttgagttaga agctcaaatt ttataagttg attactttat aataatcagt
      301 gcgtaagcac acatcatctt gtgaaacggt caataagagc atagcatata tttgccagcg
      361 attgaagacg acagcagtca tgaatatttc agaatacggg aacaggcaca ggatacagac
      421 ggatttatac gggaaatccg gtcagtatat aaagagacag agcctgagaa attctataga
      481 tcatgagaga agcagatggt gaatgaactt atctgcttct ttttttgtgc agatatagca
      541 aatataaagg atatggttgg agataaacgc tttgcgagga tgtgtctcac atgcgttcga
      601 cttgaatata tagagaaata agaatcattg tgccggtttt gaggcagtat acaattgctg
      661 aatgatagaa ctgtatttgc cggtacatga cgacaggaaa agaggaacat gtcaaatgga
      721 ttatgaaaga caacagcatg cgcccatata tgaagcactg gaacgtttcc gaaagaagag
      781 agtcgttccc tttgatgtgc cgggacataa aagaggaaga ggaaatccgg agcttgcaca
      841 gttgctggga gagaaatgtg tggggctgga tgttaattct atgaaaccgc tggataatct
      901 ctgccacccg gtttcggtga tcagagaagc ggaggagctt gcagcagatg cttttggcgc
      961 agcgcatgca ttccttatgg taggaggaac cacatctgca gtgcagagca tgatcctgtc
     1021 tgtctgcaag gcaggggata agatcattct gccgcgaaat gtacataaaa gtgccatcaa
     1081 tgccctggta ctgtgcggtg caattccggt ttatgtaaac ccggaggtga atgcgcagct
     1141 gggcatttcc cttggcatgg aagtcagtca ggtggagaag gctatggatg agaatccgga
     1201 tgcggtggca gttcttgtaa ataaccctac ctattatgga atctgttcgg atctgcggac
     1261 tatcgtaaag aaggctcatg caagaggaat gaaggtgctg gcagatgagg ctcatggaac
     1321 ccatctttat ttcggcagaa accttcctgt atccggaatg gcggcaggtg ctgatatggc
     1381 ggcagtttcc atgcacaaat ccggcggaag tctgacacag agttcgctgc tgcttttgaa
     1441 taagagtatg aatgcagaga aagtgcgcca gatcatcaat ctgactcaga ccacaagcgc
     1501 ttcttatctt ctgttgtcca gtctggatat ctccagaaga aatctggcac tcaggggaga
     1561 ggaatccttt gaaaaggttg cagggatggc gcagtatgcc agagaggaga tcaatgagat
     1621 cggcggttat tatgcatatg gtatggatct gatcaatgga accagtgttt ttgattttga
     1681 tgttacaaaa ctctctattt atacactggg aaatgggctg gcaggtattg aagtttatga
     1741 tcttctcaga gatgaatatg atattcagat cgagtttgga gatatctgta atattctggc
     1801 ttacatttcc atcggagaca ggcttcagga tattgagaga ctggtagggg cattggctga
     1861 tattgaacgt ctgtataaga aggacagcac aggtatgctt tccggggaat atatcgcacc
     1921 tgcagtggtg gcgtctccac agcaggcatt ttatgcggag aaagaatctc tgcccatgga
     1981 acaggcggca ggcaggatca gtggtgaatt tgttatgtgt tatcctccgg gaatcccgat
     2041 tcttgctcct ggggaaatgg tgacacagga aattgtagaa tacattcttt atgcaagaga
     2101 caaaggctgt tccatgcagg gaatggagga tccgaaggta gaacgtcttc aggtcctgaa
     2161 agggggtatc tgatcatgga attatggtat tccgagttcc atacaggaaa tgtaaagctt
     2221 tctgtccgga ttaaccgaca gttattttca ggggaaagtg aatttcagag aatcgatgtg
     2281 tttgagtctg aagaatttgg aagatttgtg gctctggacg gtgagatcgt attctctgat
     2341 aaagatgaat ttatttatga tgaaatggtc acgcatgtgc caatgacagt acatcccaat
     2401 gtaaaaaatg ttctgatcat cggcggcggt gacggtggag ttgccagaga actgatccat
     2461 tatccacaga ttgagagcat tgatgtggtg gaatccgata aaatgtttgt ggatgtatgt
     2521 gcggagatgt ttccggatat tgcccaggga ctgaaggatg agagagtcaa catttattat
     2581 gaagacggcc ttcggttcct gcggaataaa aagaccagat atgacctgat catcaatgat
     2641 tccacagatc cgctgggaca tacagaggga ctttttacaa aggaattcta cggaagctgt
     2701 tatacggctc tcagagatga cggaatcatg gtttatcagc atggaagtcc tttttatgat
     2761 gaggatgagg tggaatgcag aaagatgcac agaaaggttt tccggtcatt tccggtgagc
     2821 agggtttatc aggcacatat ccctacctgt ccctcgggat actggctttt tggatttgca
     2881 tcaaagaaat atcatccact ggaagatttc aggccggaga ggtttgataa tcttaatata
     2941 gaaacatggt attatacaac aaatcttcac agaggagcat ttatgcttcc aaaatatgta
     3001 gaagatttac tggaagagga ggaaaacagt ttatgagcag attattggta atcggatgtg
     3061 gtggggtagc ttcagtggca attcgcaaat gctgtcagaa cagcgatgtt tttacagaga
     3121 ttatgatcgc aagcaggaca aaggaaaaat gcgatgcact caaagagaag attgaaagta
     3181 caacgaagac aaaaattgag acagcaaagg tagatgcgga taatgcagca gaggtcgcag
     3241 aattgatcag agcctataag ccggatgctg tcctgaatgt ggcacttcca tatcaggatc
     3301 ttaccatcat ggatgcatgt ctggaagccg gtgcggatta tattgatact gccaattatg
     3361 aagcagagga tacagaagat cccacatggc gtgcaatcta cgaaaagaga tgtaaagaaa
     3421 aaggctttac tgcatatttc gattattcct ggcagtgggc ttatgatgaa aaatttaagg
     3481 aagcaggact gactgctctt ctgggaaccg gttttgatcc gggtgttacc agtgtattca
     3541 gtgcttatgc cctgaagcat tattttgatg aaatccatac cattgatatt ctggactgta
     3601 acggtggtga tcatggatat ccttttgcca caaactttaa cccggagatc aatcttcgag
     3661 aggtttccgc aaatggttcc tactgggaag acggacattg ggtagaaaca gagcctatgg
     3721 aatttaaatc tgtctacgat ttccctgagg taggaaagaa ggatatgtat cttcttcatc
     3781 atgaagagat tgaatcactg gcaaaaaata ttccgggagt acagaggatc cgtttcttta
     3841 tgacattcgg acagagctat ctgacacata tgaaatgtct ggaaaatgta ggaatgcttt
     3901 ccaccgcacc tgtggaattt aatggacagg agattgtgcc gatccagttt ttgaaagctc
     3961 ttctgccgga tcctgcatct ctgggtccga gaacagtggg taaaacaaat atcggctgta
     4021 ttttcacagg tattaaggac ggaaaagaga aaagtattta tatttataat gtatgtgatc
     4081 atcaggaatg ctataaagag gtggaatccc aggcaatctc ctatacaaca ggtgttccgg
     4141 ctatgatcgg ttccatgatg gtagtgaccg gacagtggaa gaagccgggt gtatttaatg
     4201 tggaagaatt tgatccggat ccatatatgg aagcactgaa caaatgggga cttccatgga
     4261 aagtctgcga agatcctgaa ctggtaaagg tctggaaagc caatgaagat tgatcaactg
     4321 caaactccct gctatgtgat cgatgagaag aagatgcggg agaatctgga gattttgaaa
     4381 aaagtccagg aggataccgg gtgtaagatc cttctggcgc agaaagcgtt ttccggcttt
     4441 gctctgtatc ccatgatcgg aaaatatctg gcaggtacca ctgccagcgg tctgtttgag
     4501 gcaaggcttg gatatgaaga gatggggaaa gagaatcatg ttttttcccc tgcttaccgt
     4561 acagaagata tagaggaact ggatcggatc tgtgaccata ttatctttaa ttccacagca
     4621 cagctgaaga aatttaaaga agtgtgtacc ggagccagtc tgggactccg tattaatccg
     4681 gaatgctcca ctcaggggga tcatgcaatc tatgatccct gtgcgccggg ttccaggctg
     4741 ggggttacca gagagaactt tgacgtggaa tgtctgaaat ggatcgacgg actgcatttt
     4801 catacgctct gcgaacagaa tgcggatgac ctggagaaaa cattgcaggc ggtagaggag
     4861 aagtttggag aatttctgtc tgaggtttcc tggctgaata tgggcggcgg acatcatatt
     4921 accagagagg attatgatgt aaagcttctg gaaaaatgta ttcagcatat gaaggaaacc
     4981 tatgatctgg atatttatct ggagcccggg gaggctgttg ccctgaatgc cggatatctg
     5041 gtgacagagg ttatggatat tgtggagaat ggaatcagaa cgctgatttt ggatgcttct
     5101 gcagcctgcc atatgccgga tgtgctggag atgccctatc gtccgcctct taaggacagc
     5161 ggggaagcag gggagaaggc atatacctac cgcttatctt cctgcacctg tctggcagga
     5221 gatgtaatcg gagattattc ctttgacaga gagatccgga tcggggacaa gctgtatttt
     5281 atggatatgg cgatttattc tatggtgaag aataatacat ttaacggtat gccgctgccg
     5341 gatattgcgg ttatgcatga ggacggagag tgtgaggtta tcagacattt cggatacgaa
     5401 gactttaaga gccggctttc ctgatatctg ccgggctatc aaagaaaagg agacagacat
     5461 ggaagttaca gagaagaaca gaacaaaata tcgtatgccc ggagaatttg agcctcatga
     5521 gggatgtgtg atgatctggc cggaacgtcc cggttcctgg aattatgggg caagggaagc
     5581 acagaaagca tttgtgaaag ttgcagaggc tattggagag agcgaaaagg tgtatatgct
     5641 ggtttccaaa gctcagatgg agaatgcaaa gaatcagctg gggaatgttt ccggtgtgac
     5701 tttgctggaa tgcgagacag atgacgcctg ggccagagat gtgggagcaa ccatggttct
     5761 ggatgagaaa ggggcggtct gtggagttga ctggcagttt aatgcctggg gaggagactt
     5821 tgatggactt taccggaact gggagaagga cgacagggtg gctgccttta tctgcaggac
     5881 tcttggttgt ccatgtctgg atgccagacc ttttgtgctt gagggcggtt ccatccattc
     5941 tgacggagag gggactctga tcgttacaga ggcctgtctt ctgagtcagg gacgcaatcc
     6001 tcagatgagc agggaacaga tagaggaaca gttgaagtac tggctcggtg tccacaagat
     6061 tatctggctt ccatgtggaa tctatcagga tgaaaccaat gagcatgtgg ataacgtgtg
     6121 cgcttttgta aggcccggag aggttgtgct tgcatggaca gaggatgaga cagatccgca
     6181 gtatgccatg tctttggctg atctgaaggt gctggaacag gaaacagatg caaaaggcag
     6241 aaaatttaag attcataagc ttccgattcc tcagaaaccg gtctgcctta cccgggaaga
     6301 tgtggatggc tttgtgtttg aagagggaga agacgaacgg gaagcaggag aacggatggc
     6361 tgccagttac gtgaatttct atatttccaa tggagggatc atccttccac aatttgggga
     6421 tgaaaatgac aaaagggcag tggagattct gcagaagtgt tttcctgaaa gaaggattta
     6481 tcccattgat gccagagcca tcattgtcgg cggtggaaat attcactgta ttacccagca
     6541 gattcccgga aaaatatctg accttgatgc agaaaaactt tgagagtcat gtgtttgagg
     6601 gttattacct gaaagttatg aaaaaactta cttatgtaaa caggagcagg aggaacagac
     6661 aggatgagaa atgtaacagt ggcagcagtt cagatgaaat gcagtaaaag tgtggagaaa
     6721 aatattgccc atgcagagga actggtgcgt caggcagcag caaagggagc tgagattgtt
     6781 cttcttccgg agctttttga acggccctat ttctgccagg agcgcagata tgagtattat
     6841 gaatatgcgc agactgcaga ggaaaaccct gcagtgcgtc atttcagcag ggtagcggca
     6901 gagctgggga ttgtgatccc ggtcagcttt tatgaaaaag aggtcaataa tacttataac
     6961 agcgttgcgg ttctggatgc agatggaaag aatctcggca tttatcggaa aacacatatt
     7021 ccggatgacc attattatca ggaaaaattc tatttcacac cgggagatac cggctttaag
     7081 gtttttgata ccagatttgg aaccattgga gttggaatct gctgggatca gtggttcccg
     7141 gaaacggcaa gatgtatggc actgcaggga gcagagcttc tcttttatcc cactgccatc
     7201 ggaagtgaac ccatcctgga atgcgacagc atggaacact ggagaagatg tatgcaggga
     7261 cacgctgcct ccaacctgat ccctgtgatc gctgccaaca gaatcggtga ggaaacagta
     7321 gagccatgtc cggaaaacgg aatgcagaaa tctgctctta atttttacgg ctcttctttt
     7381 atcacagaca acacaggtgc tctctgtgca gaactgcccg gaggggaaga gggggtgctt
     7441 gtaagcactt ttgacctgga tgcattaaag gcagacagac tgaactgggg acttttcaga
     7501 gaccgcagac ctgaaatgta tgcaaaaatt gtcgggaaat gacatacaag ccaaaattcc
     7561 attgccgcag gcaatctgga atgaattttg gctcagttac tgagaacgga gtgaacagta
     7621 actgagttta taagaatttc ataaaaagtt tatgattata ttagttgcta cctgcggtat
     7681 atatggtaaa ataagagtac gaacgttact gataacggat cgagcagtag agttttgaca
     7741 tgtatttctg gcaaaatgga gtgtagaaga tgaacagaaa agaatttttg gaaatcctga
     7801 gaagccagct tgccgggcag atgcaggaag gcaaagcagc ggcacatatc aggtattatg
     7861 aagattatat acagtctcag gtacgtggcg gacgttcaga gcaggaagta ctgcaggaac
     7921 tgggagaccc gcatctgata gcaaaaactc tgatcgatac agatgatgga agtacacagg
     7981 aagattacgg agagtattct tcttacggaa gcagttatgg caatgagaca gagcttcctc
     8041 atcagcagga gaaaagatgg aaaaaagtaa tcgatctttc tacctggcat ggcagggctg
     8101 ttgttattgc agcggcggct gttataattg ttttactgat acttataatc ggagttgcga
     8161 ttccgttttt tattattctt gcaattattc tttattttct ttcatggctg aagaaaagaa
     8221 atgatcaatg aaaatctatg cagggtttca gaaaagaaac cctgcgcaga atcttaaaaa
     8281 tcttaagtgt aaacgttctt gtttcacgat attaattccc cttgaatatt tataatcata
     8341 catttcaact tatttctatt ctttaatcct gccaggtgca gggaaaaatc ccacattcat
     8401 ttttatattt tttgttcgga aaggagacgg aaaatgaaac acaatttcaa actgaaacaa
     8461 cgccttggag ctttgctgct tgcaatgctt tttattctgc aggcaattct ggggcttgtg
     8521 cctgtctgcg taactcaggc ggcaccgtta actgtagaaa catgggacag tgacaaggtg
     8581 gtagattatg gttatcgctt taacatgaag tttcagcccg gaattaccac atatgaatct
     8641 tttgggtgtg ataatctgga cagggaagct ttttcagaca atggaaaaag cgaacgtgac
     8701 acagagtgcg ttcgtgtagg agcggactat aaagccggaa gcgcagggat gcgttataac
     8761 aatgtaggaa aagatggaaa tggaaatatt gttgatgtca gactcattct tgtgggagta
     8821 gagaatgcag aaccccgtta tgatctgcgc actgcagaat cgattgttca gaataaaggc
     8881 ggagctacgt ttgcatggaa agataatgaa gcttatccaa tggttggctt ttccaaaaac
     8941 agtatcggtg tatttattta ttctgtagga tacgcaaagg ttaagtttca gtttctgaag
     9001 catggaacag aagaaacatt gccgatcagt ggccatggaa ccatacgtga tattgatgcg
     9061 ggacagggag tccgtattcc gtcagacagc agtctggata atgcatatgt tctgaaaaac
     9121 aatgattatc tgacggtaga tgggaattct gtaagctcac cccttggttc cgttgagccg
     9181 gatgatccga gaggatggct gaatcttttt tataatacag ataattttac ggtagaattc
     9241 tgtcatcagt tcagactgga taaatgggat aaaagtcgtg aagatgccat tgcaaaagcc
     9301 ggttctcaag aaagatgggc agagattaca agaaataaat atttggatcc atcaggcaac
     9361 agttattgtc cgaactttaa aggacagaaa tactgcaaag catatgcata ttttgatttt
     9421 acatcctatt gtttcggtga tgttgagatg aaaaaagcgc ctgagaaacg tgtgggagag
     9481 gcaaactgta catgggaaca ggcagctgcc acatcaaaag aaaaaccttt tggcattcgt
     9541 cagggacagg aatttcagta tatgatccgg gcagaggtga cacccaatag actgaaatcc
     9601 tttgtggtac aggatatact tgaggattgt cttactatag aggatgcatc aaaagtcagt
     9661 attgtgaatg atgcagggca gacagtgaca gactggtttg atgttgctgt tgaaggacag
     9721 aaagtgacct gcagggccaa agcagagagc cttcaggatg aagcatttac agataatcag
     9781 acttacacat ttactttaaa agtacgccag agaccggaat cagaaattaa catttcaaaa
     9841 taccttgcag aggatggata cagtattctt gtaccaaacc atgcatccat gagttatgaa
     9901 cgtacaaacg gaagcggaga tacaatggat acggaaacag tgtgggtaaa gggtgtgatt
     9961 ccaccggaac tggaagtaaa gaaaaatact tctcagtatg aatggaaaac gggagatatc
    10021 atagattatg aggttctggt ttctcagaca aaacaggatg taaaagcagt aaatgttgtt
    10081 attacagacg agcttccatc atgtctgcag cttctggaag ggcagtatgc tgtagagaca
    10141 agtcagggag gcgagaactg tacgcttacc ggacagggag aaaatggatg gaaagcagag
    10201 tgtccgtccc tgaagtatgg ggagacgatc acaatccgtt ttaaatgtca ggcatctgcg
    10261 gattccaatg gacaggaatg ggaaaatatt gtgactgcaa cagcggataa tctgatcaat
    10321 cctgagacag gagaacagga atccagaaag gatatggcag aagtatggcc gaacagtcca
    10381 cagcttgaaa ttgataaaac agcagacaaa tatgaatggc aggcaggaga gcaggtagct
    10441 taccggatcg tggtgaataa tgtaacggca ggaacaatcg caaaagatgt aactattact
    10501 gatattggtc tgccgcaggg actggttctg gcaggtggtg cacagagcat ggaagtactg
    10561 ggagttcagc aacaggtaaa ctatcccgta ccggataaga aaacaggaca ggcatatgaa
    10621 gcgagacctg tggattctca gttgaatgca gatgagaacg gattttcctt ttattgttct
    10681 tatgtgccat acagtcagcc tgtaacgatt attttccatt gtatcgcaca ggaagaggca
    10741 aatggacacg aaagcgtaaa tgcagcaact gtaaaagctg ctaatacaga tgagagatct
    10801 gatgatgcag aagtatatgt aaattcagga gaattctgga ttgagaaatc tgcagatcat
    10861 tatgaatggc aggtcggaga acaggtacag tacaatgtgg tggtggagaa taaaaaagca
    10921 ggtacagtgg cccggaacgt aactgtctgg gataccggta tgccagcagg acttgcactt
    10981 tcatcggcag aggatgtatc ggtaagcgga atcccacaga atattacgca gctgacagca
    11041 gggagcaaag atgttttgaa ccagctcaat ccggaatttt ataatgagac atcagagaaa
    11101 ccagtgaatt atgaatttct tcaggaggga agcggatgga gactgaacat ttcagatctt
    11161 ccggcaaata ctccggttat gatttctttc ctttgcacag ttacggaagc ggcaaatgga
    11221 atggaaagca ttaatgttgc caatgtgcag gcgcagaatg cccctgtttc gcaggatgac
    11281 gcagaagtgt atgtaaatac agcagttctt tctattgaga aaagttttca gaatccatat
    11341 ctggcagccg gggacggacg tgcggaaaat gaatttcggg taggagaaca ggtgaattat
    11401 caggttacgg ttaataatct tcagaaggga tctatcgcaa gaaatcttgt gatcagtgat
    11461 ctttcccttc ctgaagggct ggctctggac ggagctgaag atgctgttac tgtaagcggt
    11521 gttccggctg ttgttcagaa tccggtggca ggaactgatg atgcaggaaa tcagctgaat
    11581 ccggaaaatt ataaagaaac agtggaaaaa ccggtcagct gtcaggttac acgccaggga
    11641 accggatgga tcgtgacgat ttcagatctt ccgtatcaga cacctgtgac tgttaatttc
    11701 cgctgtactg cgcaggaaag cgtaaatggg atggagattg taaatacagc acaggcgtat
    11761 gcagataatg cacagaaagt aaaggactcc tcaaaaatct gggtgaactc gcctgttctt
    11821 aaagtagaga agacgacgga caaaccattt tacaaatatg gtgatattat tacataccgc
    11881 attgtcctga cacaggagca gaccggatgt gtggcgcgta atgttacttt gcaggatgtg
    11941 atcgatactc agggagtacg tcttctgaag gattcggtga ttctgatgga tgagaaagga
    12001 aatgtagcag atgctgatgt acagatcaat gatgataata ctttcctgat gtcaacaggc
    12061 aggacactgg tcagggatag cagatatagt atctgcgata atgataaagg cggtcttttt
    12121 gagcagataa tgtataatcc tctggactgt caggaacaga aaagtatgat cgtggaatat
    12181 caggcggcgg tgattgatgc agccctggca ggacagaaag tgcacaatac tgcagttgca
    12241 gacagcagtg aaaagatacc tgcaaccggg gaaacagaga cagaggtaca cagtccgatt
    12301 ctggaaattg tgaaggaatc agataagaaa gagtatgcgt ccggtgagaa aggatactat
    12361 aaactgacag taagacaact gcgtgaggat gtcacagatc agaatattgt tatcgaagat
    12421 aaactggaaa cccaaggggc ttccattgta aaagacagca tttttgtgaa gaaaaacggt
    12481 atagaactga aagatgccaa aatagaggca gatgatacag gatttgtaat tcagacagga
    12541 gcatcgttgt cagatatgga taaaattgaa gtctgctatg aaatggtatt taaaacagaa
    12601 agcacagagc ctgaaaaaat tgtaaacaca gcgaaagcaa gaggtgatat ttcaccggaa
    12661 attactgcac agcaggaggc atatgtgaaa gcaaaagcag aaccgactgc cacaccaaca
    12721 ccgtctgcaa caccgaaacc aacagaaaca ccaaagccga cagagacacc aaaacctaca
    12781 gaagtaccga aaccgacaga gcagccaaaa gccacaccaa caccatctgt accgggaacc
    12841 tgcccgaaaa tgactcctgt accgacgaaa gcaccgttgg catcttacaa tggtggaaat
    12901 aatggaggaa cgacttccgg aagcggaggc agcagttacg caaattcggg tggatattcc
    12961 ggtggatacg gaagctatca gggtggttcc atggcaggaa gttctaaaac aggagatgtc
    13021 agaccgttta aaatgatggc tgttcttgga cttatcggaa tgggactgct gacaggaggt
    13081 gtggtgatct acagaagaac tgtttccggg aaaagaaata taaagggtat gccgcggaaa
    13141 tgaaaaaact cagaacattt gcagtaagta tgatcatagc agcaatcggg cttcttatat
    13201 attgtgccgg cttctatata aaaagttatg aacagaatct tgcagcaagg caggaatatg
    13261 cagagctttc ccaaatggca ggggtgaaga acagagaagg tgccggatta ttggcagatg
    13321 gcaaaaaaac tgatgaagac agcagtacaa aaaacagtga aaaaaaacgc aggaaaaaac
    13381 agagaagatc ttctgaatca aaaaacaaaa actgtacaga tgaaatcagg gaatccttcg
    13441 ggatttcctg ggaaaattta agaaagatca actctcagac agttgcctgg attactgtcc
    13501 cgggagccga tatttcttat cctgtagttc aggcggcaga tgatgaatat tacctgaaac
    13561 ataatttcag aggagaggaa gatctgtttg gatgtatttt tctggaacat gacataaaaa
    13621 agaattttac agattcccac agtattcttt acgggcataa tatagaaggt aatatgatgt
    13681 ttgcaaatct gaaccgttat gaacagcctg aatttctgaa aaaatgtcct gaaattgaga
    13741 tcacaacacc aaaaagaaag tttctgtaca aaattttttc tgtggaacag gcatcttccc
    13801 aaagcccggc atttgaatat ggatacaagt tatccagtcc tgcatacagg agacaattat
    13861 ctatattgaa aaataattcc atgtatgaca caggagtaga gcctgatgaa agggagagaa
    13921 tggtgactct gatcacctgt aattcacgtc tggataaaga aatacgtatg gcggtacatg
    13981 ggatttgcca tgaatgttat ggtatagaaa aagctgagcc gaagtgatgt tgaaatcaat
    14041 cggatattgg taactttcgt aaaggatgaa ctgttactgt tcacacatca ctatccctcg
    14101 aggtgttttg gaaaaaacta atgaaaaatc tctcgatatt ttg
//
