LOCUS       gnlProkkaFHEAOIEN_17   14139 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FHEAOIEN_17.
ACCESSION   gnlProkkaFHEAOIEN_17
VERSION     gnlProkkaFHEAOIEN_17
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 05:05:49
            Original ID  :: gnl|Prokka|FHEAOIEN_17
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14139
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14139
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3881:4139]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3882..4139
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14139
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14139
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             3..101
                     /locus_tag="ctg17_1"
                     /transl_table=11
                     /translation="MGYTQRPEPPFLRVAATCVAAFGLQKMVWGQI"
     CDS             98..1318
                     /locus_tag="ctg17_2"
                     /transl_table=11
                     /translation="MRHKFYFLIQQITWVVFLFLTLFAVKTFERALPDEIYVPFGEKAD
                     YRFGVPVSVTLKDDSEEVFYRLNGQEDAVAEAPFYTVTCKLFGIFPVKDVKVMMVDRQE
                     VTAGGEAIGIYVKTDGILVLGTAKIADAWGNECSPAQNLVQSGDYIVSVNGETVCGKEE
                     LIDKIDSYGSGREIIGVMRKGEYVEVSMNPVKGETGKYRLGIWVRDDLAGVGTLTYYRQ
                     DGSFGALGHAVSDGDTGVQMSLSEGYIYETKIVSIQKGKNGVPGELAGIIDYGKSHCMG
                     SITENSPLGIRGMLNDTAGELEGEVYEVAYKQDIALGKAYIISEVSGERAEYEIEIESL
                     DYSGDEENKGILFKVTDERLLDLTGGIVQGMSGSPIIQNGKMIGAVTHVFVSDASMGYG
                     IFIEKML"
     CDS             1401..2861
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:diguanylate cyclase (Score: 138.6; E-value:
                     6.7e-42)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg17_3"
                     /transl_table=11
                     /translation="MEQQEHIQKLADEYYEEGRARFFDHKLEEAAMLVQNALHLYKKCD
                     DMLKYATALNMLGVIYGATGNETMAVDYLVEGLECAINYQLNNITTLFYNNIGSRYQEL
                     GEHEKAIDYFLKSARELQNPTCIKEERHRSWALITYLNLAVSYYELNLYELSYKYLEQA
                     ERQLDEEVEEMYYYTVLIFKCRLLWQMGKGDYVYEYMEDLLASGEKDSNASDYLNDMKD
                     LCQLFRDMKEYEYWKQTISAVETYTIDQKTVFFQLFLTELWMDYYQTVGNEERYVELCV
                     AHADLYKRQKAIDAKDRATAIDIKIQLREKEAERKRVETMSVTDALTGLGNRYSLEREA
                     VHIIRDAGSERITVGVLDIDCFKQLNDTYGHIQGDRCLKVVADILKEAVMDCGHVYRFG
                     GDEFVMLFPAGMENRIGEIAEAILQKIAEVGIANEHSVVQPNLTISQGYACFVPEGTES
                     GARLIEHADKALYYVKRNSRNAYYIIRE"
     CDS             2861..2971
                     /locus_tag="ctg17_4"
                     /transl_table=11
                     /translation="MHILQLTTCFDKFSCVGISIISKQRVLSQEGLKWKN"
     CDS             2959..3756
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 89.4; E-value: 4.1e-27)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg17_5"
                     /transl_table=11
                     /translation="MEKLNVAIADDNERMLRLLGDIIESDDELNVVGVARDGEEAYHVI
                     KAKEPDVVLLDIVMPKLDGLGVLDRVSQDTSIKKHPAFIMISAIGQEKITEDAFARGAD
                     YYIMKPFDNDIVLSRIKNVRRPAAGRGAEVRKVNAYEKAEETKERNLEADVTDIIHEIG
                     VPAHIKGYQYLRDAIVMSVNDMDMLNSITKILYPTIAKKYQTTSSRVERAIRHAIEVAW
                     SRGKMDTIDEMFGYTIHNGKGKPTNSEFIALITDRIRLEYKMH"
     CDS             3882..4139
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_6"
                     /sec_met_domain="PF05402 (E-value: 2e-12, bitscore: 39.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.5e-09,
                     bitscore: 29.6, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKNKYQLRCAAGKYWLLDMEQDGETYRPPLMLNESGAYIFRQYT
                     AGNTADKIAEELATMYGGTADDMRTDVMQFIRQMELQGIL"
     CDS             4143..6314
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 61.8;
                     E-value: 1.2e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg17_7"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.1e-13, bitscore:
                     41.2, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNILLVGSKCRFLQLLTDKLDKEGHRVFLLTAEDKSVRTSKKIFE
                     TYHFAYDNPCIREVLEGVRPDVTVFMGAYDTGFLWGKGSSTASAYTSGLFQLLMNETAG
                     NVGRFLYLSSEEVFGGEYTQEISCEENCAAYTVRAQAIAAGEELCRSYFNMGYETIVLR
                     LDHLYGEPLTGAEARDICARMSVEGLETGEIRVNPHNRVALLHYSDAVEFLYAVITAKK
                     MMYGVYQISSGETISVQSAAELVAAELDGVKVVEDTGRERMDPVLSNQRFAEEFGIRIV
                     HKPETEIGREAAYIRQHASSFVRTQSRKKGWSRFGERSREAVRAMIPFAENLLCFLPFF
                     LLNNWMAGSAYFQNIDFYLLYVLLFAITYGQQQATFSSILAVAGYLAVQMYQRSGFDVV
                     LDINTYIWIAQLLILGLVIGYMRDRLHAVEEEERHEVDFLSRQVEDISDVNGSNVRIKE
                     ILSNQIVNQNDSFGKLYEITSSLDKYEPSEVLFYAAEVLAKLMDSQDVAIYTVANHSYA
                     RLFSATSPKARMLGNSIHYVQMEELYEKLREKKVFINKTMDERYPLMADAIYSEDEMQL
                     ILMVWGIPWERMTLGQANMLTVIGYLIQNAVVRANRYLSALEQQRYIHGTRILEADAFA
                     SLVNAYLNAREKKLTECALVVFEEGEISREEAAGVLSGMMRQSDYLGELSDGKMYALLA
                     NTSAEDAGMVVERFRSAGFPCRMKEEMEL"
     CDS             6311..7228
                     /locus_tag="ctg17_8"
                     /transl_table=11
                     /translation="MSRIETYFLLLVVLNLCITAAYVLWNEQHWREEPGKRTGGRIRAA
                     VMLLAPVIGPVFFVAGELARHLLFGQSADLEDVIFSKERVRTHFMANEEQERNVVPIEE
                     ALAISDRDSLRTLIMNVVRGDVTDSLGSLALALDSEDTETSHYAASVLRDVLNDFRQHA
                     QKLYRQMQKDGREAGDDACLLIEYMYVVLKQNVFHETEQRTFVDMFEEACELLYEKDYR
                     KLTAQYIEWLCELLLRLKEFGRMRYWCNRSRELYPDALSTYTCYLKMYFTQEKKTEFFR
                     ELDRLKASNIVIDRETLELIRTFS"
     CDS             7249..9126
                     /locus_tag="ctg17_9"
                     /transl_table=11
                     /translation="MVSRRNYLTIAMMFVILLFMFQFTGVMKEQLSEYESNEYADDTTT
                     SFQRSDAFLAEQTSADACEVIYVGEAGGAEESVVKTWCSYRKRTFFCSSSLALLDSLQD
                     DALQVLVVDGSKVTSEEEVAVLRREAQMGVTVIFATLPQSSVIREYRDLRELLGIRAVI
                     ADEIPLAGMHLFSGFLLGGEEIYEVTEPGEEERQDMNPSVPWYTTGAGTKTYMVGTLSD
                     ETIEQTVDNEIRAQYVGMDEEAAKNSLLPAILWRNSVDTAKIFCVNGDYLADISAVGIL
                     DAMMGETYDYDIYPVINAQNLVIADLPAFVSENEEEMQKRYSQSAQAVYQEIVWPSLTS
                     IASRTGAKMTCMMTPQFTYTDEEEPDGENVTYYLKRLKEEHAEAGLSADSREGIPLSEK
                     IKQDQTFWQTYAPSYRFLSLYADGVKSIGEESALPAEIRTVALGSGASEAVGYLNENVT
                     LQPSTSSGIRHTFLDDFKVKCMETALGYSNITLDLYSVTYPEGDEDSWEKMSKKIAANL
                     GTYWKAYEAFDATTLTESDVRIRRFLALDYKQQRTDNVIILSLEHREDAAWFLLRLHGE
                     EVTEVAGGSFEEVEDGVYLILAEEDEVSVEVQTGEEWQYQDGGKRGDGT"
     CDS             9195..10547
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 111.3;
                     E-value: 1.1e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg17_10"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1e-22, bitscore:
                     72.4, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKIFPEYQFVVLAIVANRSLRGKFVYDLPENVVEVHELYLEDAD
                     WRPKELKRAARLKLNEREYAALRSLLMNQNVDWDTLFSFFGEKEFSLNELLMGEDFFRA
                     VQECYTVRYAGAVFSDFLWTMRSMYLPLFLTLGMRLPRADVYHCVATGYAGVLGSMAKR
                     RFGCRLLISEHGIYTREREEELIRADWVSGIYKNIWIEQFKKMSKLAYDRADLVTSLYA
                     HARELQIELGCPADKTSITPNGIDPARFDGLKRPEVMEPDMVHIGAVLRVTPIKDVKTM
                     IRAFAYAKRDVPNLKLWIMGPTDEDEEYARECFDLVELMELPDVVFTGRVNVSEYLGGL
                     DFTILTSISEGQPLTILEGYAAKLPAIATDVGNCRGLLYGEDDDFGEAGILTHIMNVKE
                     IADAMVNLARHPVCRKQMGENGYRRVMAKYKISDMQQTYRKIYETFENIDW"
     CDS             10562..12013
                     /locus_tag="ctg17_11"
                     /transl_table=11
                     /translation="MAGIGIKLQKIYEKKTILAYLTGFGYSAVVTVAPMFVVIGTIMLM
                     SQLLGYENVGYARRGLFSGTLLYIFIFSLLTAAPFNAVLSRYMSDVIYEERYEDILPCY
                     DVGLLLNILLASLLGIPFCVWEHLAGHVNLIFVFTGFCGYIALVLVFYSMLYLSICKDY
                     QKISLYFLTGMAAALACALFFVKVCGREIVYSMLLSLTIGFFLTAVLEYATVKRYFKRN
                     SNRYRRVFSYFGRYWKLVVINFLYTLGLYIHNFVFWNTDLQMRVADTFVFAPTYDLATC
                     LAMFTNLSSTIIFITRVEMHFHTRYKAYSEAVIGGRWEDIKNTKDRMFRQLSAELMNLV
                     RIQFIISTAVYLLCVVVLPQYGFSGRVMQIYPCLAAGYFILFILYAEIIFLYYFNDLTG
                     ALLATLGFCLVTWAGSVLSAGGSDLWYGMGLVAGSFTGFTIAYFRLRFMERHMDEHIFC
                     GGQLFTVKRERMPESMVYTKKQKER"
     CDS             12017..12397
                     /locus_tag="ctg17_12"
                     /transl_table=11
                     /translation="MNVILILRIFLTAAGVLFLLGDINAYVRQKLTDTIGLLWAFVSVA
                     LILTGVVSVPGAREEEYLVVLLLAVCLLLLILLFKLSKVVSVLSMKNQELAMQVSLLNQ
                     ENERILHRLGILTDEKKDIVRD"
     CDS             12369..13598
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 100.2;
                     E-value: 2.4e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg17_13"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.5e-25,
                     bitscore: 80.9, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKILFVINTLSRAGAETALLELLAQLAAERGEDGQPRYELSLF
                     VLMNQGELVQQIPEGVRLVNPRYAQVSVLEPKGRIYMGMTVVKCLLHRANLIRLWRYHW
                     RAARAMRKEGRLMPDKLLWRAISDGARRFPEEYDLAVAFLEGGSAYYVADHVRAKKKAA
                     FIHIDYQKAGYSRELDRDCYLQYDAVFPIGEQVKRAFLAVYPECSARTRIYHNRIDCEK
                     IRKMSGQPGGFTDDFDGIRLLTVGRLTPQKAYPVAIEAMRQLKAEGYPVRWYVLGEGSS
                     RRELEQHIASCGLKEDFLLLGAVENPYPYYRQTDIYVHATGYEGKSIAIQEAQTLGCAI
                     VASECNREQIIDGEDGILCALDAAAVKEAVGFLIRNPDRRRAYAQAALKRPVNYENEER
                     LLEQLLSEKE"
ORIGIN
        1 caaggggtta cacccagcgt cccgagccac cctttttaag ggtggcggcg acttgtgtgg
       61 cggcctttgg gttacagaaa atggtatggg ggcagatatg agacataaat tttatttttt
      121 gatacagcag atcacgtggg ttgttttttt gtttttgacg ctgtttgccg taaagacgtt
      181 tgagcgggca ctgccggatg agatctacgt tccgttcggg gaaaaggcgg attaccggtt
      241 tggcgttccg gtgagcgtga cgttaaagga cgacagcgag gaagtgttct accgcttaaa
      301 cgggcaggag gatgccgtgg cggaggcccc tttttatacc gttacctgca agctgttcgg
      361 cattttcccg gtaaaagacg tgaaggtgat gatggtcgac agacaggagg tgactgcggg
      421 cggcgaggcg atcggtatct atgtgaagac ggacggaatc ctggtgctcg gtactgcaaa
      481 gattgcggat gcgtggggca atgagtgcag cccggcgcag aatctggtgc agagcgggga
      541 ttatattgtg agcgtgaacg gggagacggt gtgcgggaaa gaggagctga ttgacaagat
      601 tgacagctac ggcagcggac gtgagatcat cggagtgatg cggaaggggg agtatgtgga
      661 agtatccatg aatccggtca aaggcgagac gggaaaatac cgccttggaa tctgggtgcg
      721 ggatgatctt gccggggtcg gaacactgac ctactacagg caggacggaa gctttggcgc
      781 actcggacat gcggtgagcg acggcgacac cggcgtgcag atgagcctgt cggaaggata
      841 tatttacgag acgaaaatcg tcagcatcca gaaggggaag aacggcgtcc cgggcgaact
      901 tgcggggatc attgactacg ggaaatcgca ttgcatggga agcattacgg agaactcgcc
      961 gcttggcatc cgcggcatgt taaatgatac ggcgggagaa ctggaagggg aagtctacga
     1021 ggtggcttat aagcaggaca ttgcgcttgg aaaagcctac atcatctcgg aggtgtccgg
     1081 ggagcgcgcg gagtatgaga ttgagataga gagtcttgac tacagcgggg atgaggaaaa
     1141 caagggaatc ctttttaaag tcacggatga gcggctttta gacctgaccg gaggaatcgt
     1201 acaggggatg agcggcagtc cgattatcca gaacggaaag atgatcgggg cggtgacgca
     1261 tgtgtttgtg tcggatgcgt cgatggggta cggaatcttt attgagaaaa tgttgtgatt
     1321 gtacgacaaa aacttttaca acgtctggta cttatggtat actacagtca gtattgttgg
     1381 ctttaaggac ggaagatgga atggaacagc aggaacatat acaaaaactg gcagatgaat
     1441 actacgaaga gggcagagcc agattctttg accacaagct ggaggaagcg gcgatgcttg
     1501 tacagaatgc gcttcatctc tacaagaagt gcgacgacat gttaaaatac gccacagcgc
     1561 tcaatatgct cggggtgatc tacggcgcca cggggaacga gacgatggcg gtggattatc
     1621 tggtcgaagg acttgagtgt gcgatcaatt accagctaaa taacatcacg acactctttt
     1681 ataacaatat cggctccaga taccaggaac tgggagagca tgagaaggca attgattatt
     1741 tcttaaagtc ggcgcgggaa ctgcagaatc cgacctgcat caaggaggaa cgccaccgtt
     1801 cctgggctct gattacctac ctgaatctgg cggtctccta ctacgaactg aacctgtacg
     1861 agctttccta caaatattta gagcaggcag agcggcagct tgacgaggaa gtggaggaga
     1921 tgtattatta tacggtactg atcttcaaat gtaggctgct ctggcagatg ggaaaggggg
     1981 actatgtgta tgagtacatg gaggaccttc tggcgagcgg tgaaaaagac agcaatgcgt
     2041 cggattatct gaacgatatg aaggatctgt gtcagctgtt ccgcgacatg aaagagtatg
     2101 aatactggaa gcagactata tctgcggtcg agacctatac gatcgatcag aaaaccgtct
     2161 ttttccagct gtttctgacg gaattgtgga tggactacta tcagactgtg gggaacgaag
     2221 agcgctatgt ggaactgtgt gtggcacatg cggatctgta taagcgccag aaagcgatcg
     2281 atgcgaagga ccgcgccaca gcgatcgaca tcaagatcca gctgcgggaa aaagaggcgg
     2341 agcgcaagcg cgtggagact atgtctgtga cggatgcact gaccgggctg gggaaccgtt
     2401 attctcttga gcgtgaggcg gtgcatatca taagggatgc gggcagtgag cggatcacgg
     2461 tcggcgtttt ggacattgac tgctttaagc agctgaacga tacctacggg catattcagg
     2521 gagaccgctg cctgaaggtg gtggcggata ttctgaagga ggcagtgatg gactgcggac
     2581 atgtctaccg gtttggcggg gatgagttcg tgatgttgtt tccggcaggg atggagaacc
     2641 ggatcgggga gatcgcggag gcgatcctgc agaagattgc ggaggtggga atcgcaaacg
     2701 agcactcggt tgtgcagccg aatcttacca tctcccaggg gtatgcctgc tttgtgccgg
     2761 agggcacaga gagcggagcg cgtctgattg agcacgcgga caaggcgctt tactatgtga
     2821 agagaaacag cagaaacgca tattatatca tacgcgaatg atgcatatac ttcagttgac
     2881 gacttgcttc gacaaatttt cttgcgttgg aatcagtatc atcagtaagc aaagagtttt
     2941 gtcacaggag gggctaaaat ggaaaaactg aatgttgcaa tagcagatga taatgagaga
     3001 atgctgcgat tattagggga tattatcgaa agtgatgacg aactgaatgt tgtaggagtc
     3061 gcccgcgacg gcgaggaagc ataccatgtg ataaaggcga aagaaccgga tgtcgtgctg
     3121 ctcgacattg tgatgccgaa gcttgacgga ttgggggttt tagaccgcgt gagtcaggac
     3181 acctccataa aaaaacatcc ggcgtttatt atgatcagcg cgatcggtca ggagaaaatc
     3241 acggaagatg cgtttgcgcg cggcgcagat tattacatta tgaagccgtt tgacaatgat
     3301 atcgtgttaa gccgcatcaa gaatgtgaga agacctgcgg cgggacgcgg tgcggaagtg
     3361 cgcaaggtca atgcctatga gaaggcggag gagacaaagg agcgcaacct ggaagcggat
     3421 gtcaccgata ttattcacga gatcggagtt ccggcgcata tcaaagggta tcagtatctg
     3481 cgggatgcga ttgtcatgtc ggtcaatgac atggatatgc tcaactcgat cacgaaaatt
     3541 ctttatccca cgatcgcgaa gaagtaccag acaacctcca gccgtgtgga gcgggcaatc
     3601 cggcatgcga tcgaggtggc gtggagcaga ggcaagatgg ataccattga tgagatgttc
     3661 gggtatacca tccacaacgg aaaaggaaaa ccgacgaatt cggagtttat cgcactgatt
     3721 accgaccgga tacgtctgga atataagatg cattaacgat gaggacatat ttttcaggag
     3781 gcgcaaagcc gaagaagagt atgtcctcat tttcggataa ccggttcctt ttgagcgtca
     3841 gatgtgctat aattatacga tgatttttcg gaggatggca gatgcagaaa aacaagtatc
     3901 agctcaggtg cgcggcagga aaatactggc tgttagatat ggagcaggat ggagaaacgt
     3961 atcggccgcc gctcatgtta aatgagagcg gggcttatat cttcaggcag tatacggcag
     4021 gaaacacggc ggataaaatc gcggaggagc ttgccactat gtacgggggg accgcagacg
     4081 atatgcggac agatgtgatg cagtttatca gacaaatgga actacagggg atcttgtaaa
     4141 cgatgaatat attattggtg ggaagcaaat gccgcttcct tcagcttttg acggacaaac
     4201 tggacaaaga agggcaccgt gtgtttttgc tgacggcaga agacaaatcg gtcagaacgt
     4261 ccaaaaagat atttgagacg tatcattttg catacgacaa tccgtgcatc agagaggtgc
     4321 ttgagggagt gcgtccggat gtgacagtct ttatgggcgc ctatgacaca ggctttctct
     4381 gggggaaggg gagcagcacg gcgtcggcgt acacttcagg cctgtttcag ctgctgatga
     4441 atgagacggc tggtaatgtg ggacgctttt tgtatctctc gtcggaggaa gtcttcgggg
     4501 gagagtatac acaggagatt tcgtgcgagg aaaactgtgc ggcttatacg gtacgcgcgc
     4561 aggcgattgc ggcgggagag gaactctgcc gcagttactt taacatgggc tatgagacga
     4621 tcgtgctgcg gctggatcat ctctacgggg aaccgcttac cggggcggaa gcgcgtgata
     4681 tctgcgcccg catgagtgtg gaggggctgg aaaccggtga gatccgggta aatccccaca
     4741 accgtgtggc gctgttgcac tattcggacg ccgttgagtt tttgtatgcg gtgattacgg
     4801 caaaaaagat gatgtacggt gtttatcaga tctcttccgg agagacgatt tccgtacaga
     4861 gcgcggcgga gctcgtggcg gcggaactgg acggtgtgaa agtcgtagag gacaccggaa
     4921 gagagcggat ggatccggtt ttatccaacc agcgatttgc ggaggagttc ggaatccgca
     4981 ttgtacataa gccagagact gagatcggca gggaggcggc gtacatccgg cagcacgcat
     5041 cttcctttgt gcggacacag agcagaaaaa agggatggag ccggttcgga gagcggtcgc
     5101 gagaggccgt aagagcgatg attccgttcg cggagaatct gctttgtttc cttccgtttt
     5161 ttctgttaaa taactggatg gcggggagtg cgtatttcca gaacattgat ttttatctgc
     5221 tgtatgtgct gctgttcgcc attacctacg gacagcagca ggcgacattc tcctcgatac
     5281 ttgcggtggc ggggtatctt gcggtgcaga tgtatcagcg gagcggtttt gatgtggtgc
     5341 tggacatcaa cacgtacata tggattgcac agctactgat tctgggactt gtgatcggct
     5401 atatgcgtga ccgtctgcat gcggtggagg aggaggagcg ccatgaggtg gatttcctct
     5461 ccagacaggt ggaggatatc tcggatgtca atggcagcaa cgtgcgcatc aaggagattc
     5521 tgtcgaatca gatcgtcaac cagaacgaca gcttcggaaa gctgtatgag atcacgtcca
     5581 gcctggacaa gtacgagccg agcgaagtgc tgttctatgc cgcggaggtg ctggcaaagc
     5641 tgatggacag tcaggatgtc gcaatctata cggtggcaaa ccactcctat gcgcgtctgt
     5701 tctcggcaac ttcgccgaag gcacgcatgc tcggaaattc cattcactat gtgcagatgg
     5761 aagaactcta tgaaaagctg cgggagaaaa aagtgttcat caacaaaacc atggatgagc
     5821 gctatccgct gatggcggat gccatttatt cggaggatga gatgcagctg attctgatgg
     5881 tgtggggaat cccatgggag agaatgacgc tcggacaggc gaatatgctc actgtgatcg
     5941 gctatctgat ccagaacgcg gtcgtgcgcg cgaaccgtta tctctcggcg ttagaacagc
     6001 aacgctatat ccacggcacc agaattttgg aggcggatgc gtttgcttct ctggtgaatg
     6061 cttatcttaa cgcgagagag aagaagctga cggagtgtgc gcttgttgtc tttgaggagg
     6121 gggagatctc cagggaggaa gccgcgggcg tgctttccgg catgatgcgc cagagtgatt
     6181 accttggaga actctccgac ggaaagatgt acgcactgct tgctaacacg agcgcagagg
     6241 atgcgggaat ggttgtggag cgttttagga gcgcaggatt tccgtgcagg atgaaagagg
     6301 agatggaact atgagcagga tcgaaacgta ttttctgctg cttgtggtac tgaatctgtg
     6361 catcacggcg gcgtatgtcc tgtggaatga gcagcactgg agagaagagc ccggaaagcg
     6421 caccggcgga agaatccgcg cggcggttat gcttttggca ccggtgatcg gtcccgtctt
     6481 ctttgtggcg ggagaactcg cgcggcatct tttattcgga cagtcggcgg atctggaaga
     6541 tgttattttc agtaaggagc gtgtcagaac acactttatg gcgaatgagg agcaggagcg
     6601 gaatgtggtg ccgatcgagg aggcactggc gatttccgac cgggatagtc tgcgcacact
     6661 gattatgaat gtggtcagag gagatgtcac ggactctctc ggatcgctgg cgctggcact
     6721 tgacagtgag gacaccgaga cctcccacta tgcggcgtcg gtgcttcggg atgtgctcaa
     6781 cgatttcagg cagcatgcac agaaactcta ccggcagatg caaaaggacg gcagagaggc
     6841 gggggatgat gcctgccttc tgatcgagta catgtatgtc gtcttaaaac agaatgtttt
     6901 tcacgagacc gaacagcgga catttgtgga tatgtttgag gaggcgtgtg aacttctcta
     6961 tgaaaaagat taccggaaac tcactgcgca atacatcgaa tggctgtgtg aactgctgct
     7021 ccgcttaaag gaattcgggc ggatgcgcta ctggtgcaac cggagccggg aattatatcc
     7081 ggatgcgctt tccacgtaca cctgctattt gaaaatgtat tttacgcagg agaagaaaac
     7141 cgaatttttc cgggaactgg atcggctgaa agcgtccaat atcgtcattg acagggagac
     7201 gttagagctg atccggacgt tcagttagtc cggcaggaag gaaacgacat ggtatcacgc
     7261 agaaattatc tgacgattgc aatgatgttt gtgattctgc tttttatgtt tcagtttaca
     7321 ggcgtcatga aagaacagtt aagtgaatat gagagcaacg aatatgcaga cgataccaca
     7381 acatcctttc aacggtcgga tgcatttctg gcagaacaga catctgccga cgcctgcgag
     7441 gtgatctatg tgggcgaagc agggggagcg gaggaatccg tggtaaagac atggtgcagc
     7501 taccgcaagc ggacgttttt ttgcagcagc tccctcgcac tgcttgacag tctgcaggat
     7561 gatgcactgc aggtgctggt ggtggacggc agcaaggtga cgtcggaaga agaggtggcg
     7621 gtgcttcgca gagaggcaca aatgggtgtg actgtgattt ttgcaaccct gccgcagagc
     7681 tctgtgataa gggagtaccg ggatttaagg gagcttctcg gaatccgcgc ggtgattgcg
     7741 gatgagatac cgcttgcggg catgcatctg ttttccggct ttctgctcgg cggggaagag
     7801 atctatgagg tcacggaacc cggggaggag gagcgtcagg acatgaaccc ttctgttccc
     7861 tggtatacga ccggcgcggg aaccaagacc tatatggtcg gcacgctgtc cgatgagacg
     7921 atcgaacaga cggtggataa cgaaatacgg gcacagtatg tgggaatgga cgaagaggcg
     7981 gcaaaaaaca gccttctgcc tgccattctc tggagaaaca gtgtggacac ggcaaagatt
     8041 ttctgtgtga acggggatta tcttgcagac ataagcgctg ttggaatact ggacgccatg
     8101 atgggggaga catacgatta cgatatctac ccggtgatca acgcacagaa tcttgtgatt
     8161 gcagatctgc cggcgttcgt ctccgagaac gaggaggaga tgcagaagcg ctacagccag
     8221 tccgcacagg cagtgtatca ggaaattgtg tggccgtcgc tgacctccat tgcctcccgg
     8281 acgggggcaa agatgacctg catgatgacg ccgcagttta cgtatacgga tgaggaagag
     8341 ccggatggag agaacgtcac ctactatctg aaacgtctga aggaggagca cgcggaggcg
     8401 gggctgtccg cagacagcag ggaagggatc ccactctcag aaaaaataaa gcaggatcag
     8461 acgttctggc agacctatgc gccgtcctac cggtttttat ccctctacgc ggacggagta
     8521 aagagcatcg gggaggagag tgcccttccg gcggaaatcc gcacggttgc gctcggatca
     8581 ggtgccagcg aggcggtggg gtatctcaat gagaacgtca cactgcagcc gtcgacgagt
     8641 tccggaatcc ggcatacgtt tctggatgat tttaaagtga aatgcatgga gacggcgctc
     8701 ggctattcca acatcacact cgacctctat agcgtgactt atccggaagg ggacgaggat
     8761 tcctgggaga aaatgtccaa gaagatcgca gcaaacctcg gcacctactg gaaggcgtat
     8821 gaagcgtttg acgcaaccac cctgacggag agtgatgtgc gcatccgcag atttctggcg
     8881 cttgactata agcagcagcg cacggacaat gtgattatac tctccttaga acacagggag
     8941 gatgcggcat ggtttctgct gcgcctgcac ggagaggaag tcacagaagt tgcgggcgga
     9001 agctttgaag aggtagaaga cggcgtctat ctgattcttg cagaggaaga tgaggtctcc
     9061 gtggaagtgc agaccgggga agaatggcag tatcaggacg gcggaaagcg tggtgacggc
     9121 acatgagaat atgtattgtg gcagagggat gctatcccta tgttgtcggg ggtgtatcga
     9181 gctggataca cagtatgata aaaatatttc cagagtacca gtttgtcgta ctggcgattg
     9241 tggcgaaccg ttcgctgcgc ggaaagtttg tctacgatct cccggagaat gtggtggaag
     9301 tgcacgaact gtatctggag gatgcagact ggcggccaaa agaacttaaa agagcagcca
     9361 gactgaagtt aaatgagcgg gagtacgccg cactgcggag cctgctgatg aaccagaatg
     9421 tagactggga taccctgttc tcctttttcg gggagaagga attctctttg aatgaacttc
     9481 tcatggggga ggattttttc cgggcggtgc aggaatgtta tacggtgcgg tatgcggggg
     9541 cggtgttttc tgatttcctc tggacgatgc gctccatgta ccttccgctg tttctgacac
     9601 ttggcatgcg gctgccgagg gcggatgtgt atcactgtgt ggcgacggga tatgcgggcg
     9661 tgctgggcag catggcaaag cgcaggtttg gctgcaggct tctgatctcg gagcatggaa
     9721 tctacaccag ggagcgcgag gaagaactga tccgtgcgga ctgggtgtcc ggcatctata
     9781 aaaatatctg gattgagcag ttcaagaaaa tgtcgaagct tgcctatgac agggctgatc
     9841 tggtgacaag cctttacgcg cacgcgagag agcttcagat cgaactggga tgtcctgcgg
     9901 ataagacgag cattaccccg aatgggattg atccggcgcg gtttgacggt ttgaagcgtc
     9961 cggaagtgat ggagccggat atggtgcaca tcggtgcggt actccgcgtg acgccgatca
    10021 aggatgtcaa gaccatgatc cgggcgtttg cgtatgcaaa gcgcgatgtg cctaacttaa
    10081 aattatggat catggggccg acggacgaag acgaggaata cgcgagagaa tgttttgatc
    10141 tggtggagct gatggaactg ccggatgtgg tgtttaccgg aagggtgaat gtgtcggaat
    10201 atctcggcgg actggatttt accattctga ccagtatcag cgaggggcag ccgttaacga
    10261 ttctggaggg ctatgcggcg aagcttcctg cgatagcaac cgatgtcgga aactgccgcg
    10321 gactgttgta cggcgaggac gatgattttg gcgaggcggg aattctgacg cacatcatga
    10381 atgtgaagga aattgcggat gccatggtga atcttgccag acatccggtc tgcagaaaac
    10441 agatgggaga aaacggttac cgccgtgtga tggcaaagta caagatttcg gatatgcagc
    10501 agacgtaccg gaagatttat gaaacgtttg agaacataga ctggtagaag ggagagagac
    10561 tgtggcagga ataggaatca agcttcagaa aatatatgag aaaaaaacga ttcttgcata
    10621 tctgaccgga ttcggctaca gtgcagtcgt gacggtcgca ccgatgtttg tcgtgatcgg
    10681 aacgatcatg ctcatgagtc agctcctggg atatgagaat gtgggatatg cgagaagagg
    10741 actgttttcc ggaacgctgc tttacatctt tatcttttcg cttctgacgg cggcgccttt
    10801 taatgcggtg ttgtcccgct atatgtcgga tgtcatctat gaggagcgct atgaggatat
    10861 tctgccctgc tacgatgtgg ggctgctttt aaacattctg ctggcaagtc tcctcggaat
    10921 tccgttttgc gtgtgggagc atcttgcggg gcatgttaac ctgattttcg tgtttaccgg
    10981 attttgcggt tatatcgcac tggttctcgt gttttattcg atgctttacc tctccatctg
    11041 taaggattat cagaagatat cgctgtactt tttgaccgga atggcggcgg cactcgcctg
    11101 cgccctcttt tttgtaaaag tatgcggcag ggagattgtc tacagtatgc tgctttccct
    11161 cacgattgga ttctttctta cggcggtgtt ggaatatgcc acggtgaagc gctattttaa
    11221 gaggaacagc aaccggtaca gaagagtttt ttcgtatttt ggcaggtact ggaagctggt
    11281 ggtgatcaat tttttgtata cactcggtct gtatattcat aattttgtgt tttggaatac
    11341 ggatttacag atgcgcgtgg cggatacgtt tgtctttgct ccgacgtatg atctggcaac
    11401 ctgtctggcg atgtttacga atctgtcgtc gaccatcatt tttatcacgc gggtagagat
    11461 gcatttccac acacgttaca aggcgtattc ggaagcggtt atcggaggaa gatgggaaga
    11521 tatcaaaaat acaaaagata gaatgttccg gcagctttct gcggagctta tgaatctggt
    11581 gcgcatacag tttatcatct cgacggcagt gtatctgctc tgcgtggtgg tgcttccgca
    11641 gtacgggttc tcgggaagag tgatgcagat ctatccttgt cttgccgccg gatattttat
    11701 attatttatt ctgtatgcag aaattatttt tctgtactac tttaacgatc tgacaggggc
    11761 gcttttggca accctcggct tttgtctggt gacgtgggcg ggaagcgtgc tttctgccgg
    11821 cgggagtgac ctgtggtacg gcatggggct ggtggcgggc agctttaccg gctttaccat
    11881 tgcctatttc agactcaggt tcatggagcg ccatatggat gaacatatct tctgcggcgg
    11941 acagctgttt acggtgaaga gagagcggat gccggagagt atggtatata caaagaaaca
    12001 gaaggagcgt tagtatatga atgtgatttt aattctgcgg atttttctga cggcagcggg
    12061 agtgttgttc cttttggggg atatcaatgc gtatgtgaga caaaaactga ccgatacgat
    12121 tggacttctg tgggcatttg tctcggtagc gctgatttta acgggcgtgg tctccgtgcc
    12181 gggggcaagg gaggaggaat acctggtggt gcttcttctg gcagtctgcc tgctgctttt
    12241 gatcctgctg tttaagctaa gcaaggtggt gtcggttctt tccatgaaaa atcaggagct
    12301 tgccatgcag gtttccctgc tcaatcagga aaatgagaga atattgcaca ggctggggat
    12361 tttgacagat gaaaaaaaag atattgttcg tgattaacac attaagccgc gccggagcgg
    12421 agacggcact gttggaactg cttgcgcagc ttgctgccga gcggggggag gacgggcagc
    12481 ccagatatga gctctcgctc tttgtcctga tgaaccaggg agaactggtg cagcagatac
    12541 cagagggggt gcggcttgtc aatccaaggt atgcccaggt ctcggtgctc gaaccaaagg
    12601 gaagaatcta tatgggcatg accgttgtaa aatgtctgct tcacagagcc aacctgatcc
    12661 ggctgtggcg ctatcactgg agggccgcgc gggcgatgcg caaagaggga cggctgatgc
    12721 cggacaagct gctgtggcgg gcaatctcgg atggcgccag acgcttcccg gaggaatatg
    12781 atcttgcagt tgcattcctg gagggcggtt ctgcatacta tgtggcagac cacgtcaggg
    12841 cgaaaaaaaa ggcggcgttt attcatatcg actatcagaa ggcgggatac agcagggaac
    12901 tggaccgcga ctgctacctg caatatgatg ccgtatttcc gatcggggaa caggtaaagc
    12961 gggcgtttct cgccgtgtat ccggagtgca gtgcacgcac caggatctat cacaatcgga
    13021 tcgactgtga aaaaattcgg aagatgtccg ggcagccggg aggatttacg gatgatttcg
    13081 acggaatccg cctgcttacg gtgggaagac tcaccccgca gaaggcatat ccggttgcga
    13141 tcgaagcgat gcggcagtta aaggcggagg gatacccggt ccggtggtat gtgctgggcg
    13201 agggaagcag ccgcagggaa ttagagcagc acattgcgtc gtgcggatta aaggaggatt
    13261 tcctgctgct tggagcggtt gagaatccct atccgtacta ccggcagacg gatatctatg
    13321 tgcatgcgac cggatatgag gggaaaagca ttgcgataca ggaggcgcag acgcttggct
    13381 gtgcgatcgt tgcttccgaa tgtaacagag agcagattat agacggggag gacgggattt
    13441 tgtgcgcgct tgacgctgcg gcggtaaagg aagctgtggg cttcctgatc cggaatccgg
    13501 accggcgcag ggcgtacgcg caggcggcgt taaagcgtcc tgtaaattac gagaacgagg
    13561 aacggctgtt ggagcagctg ctttccgaga aagaataagg aagatacgat ggtagagaag
    13621 aaacaaaaag aactgctgat tatcattccg gcatacaatg aggagaaaaa tatagagcgg
    13681 gtgctggagg agctggaacg cccggagatc gcggagattg cggatattct ggtcatgaat
    13741 gatgcgtcct cggactctac gaactgggtc gtaaaggcac acggacatac gctggtatcc
    13801 catgtcttta atctggggta cgggagcgcc ctgcagcttg gatataaata cgcgatccgc
    13861 cgcaaatatt cctatgtgat ccagatggat gcggacggac agcatgatgt gtgcaacata
    13921 ccggtgatct atcagagact aaaacagcag gatgcggacg gacgctgccc ggatatcgtg
    13981 ctctgttcgc gttttatgga gggaagtgca gagtatccgg tctccgctac gaagaaactg
    14041 gcatacggat tcttccgctg gatgataaag atcagtaccg gacgaaagat tgccgatccg
    14101 acgaccggtc tgcagggact taaccgcagg gcattttta
//
