LOCUS       c00007_gnlPro..        15295 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OMOMMHNM_7.
ACCESSION   c00007_gnlPro..
VERSION     c00007_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 19:32:03
            Original ID  :: gnl|Prokka|OMOMMHNM_7
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15295
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15295
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[435:5295]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      436..5295
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..15295
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15295
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(436..1260)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_1"
                     /sec_met_domain="ECH_1 (E-value: 4.7e-82, bitscore: 266.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYDDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKQYPKFP"
     CDS             complement(1264..2931)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.5e-07, bitscore:
                     21.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTDKKNILQLVALLEAHGITKVVLCPGSRNTPIVHTLSNHPNFT
                     CYPVTDERSAGYFAIGLALNGGKPAAVCCTSGTALLNLHPAVAEAFYQNVPLVIISADR
                     PAAWIGQMDGQTVPQPGVFQTLVKKSVNLPEIHTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINVPISEPLFQFTVDSLPEVRVITRYQGLNVYDRDYNDLVDRMNKYQKRMIIIGQMN
                     LIYLFEKRYIKLLYKHFAWLTEHIGNQTVPGIPVKNFDAALYAMPEEKVGQMVPELLIT
                     YGGHVVSKRLKKFLRQHPPKEHWHVSPDGEVVDLYGSLTTVIEMDPFEFLEKIASLLDN
                     RTPEYPRVWENYCKIIPEPEFAYSEMSAVGTLLKALPESCALHLANSSVVRYAQLYSIP
                     STIEVCCNRGTNGIEGSLSTAVGYAAASDKLNFIAIGDLSFFYDMNALWNVNVRSNLRV
                     LLLNNGGGEIFHTLPGLDMSGTSHKFIAAVHKTSAKGWAEERGFLYLQAQNDEELAEAM
                     KTFTQPEAMEQPVLLEVFTNKNKDARMLKNYYHQLKQK"
     CDS             complement(2951..4066)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_3"
                     /sec_met_domain="Chorismate_bind (E-value: 2.2e-57,
                     bitscore: 186.3, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDEEISNLTTIDAFIQRKQPFAVYRIPGEKVPRLLTQAEGAVRL
                     IYDLKELNGQRGFVIAPFQVSESCPVVLIQPDQWGQPLPVDDDTEEDREIALRLQGQES
                     FLTSSTEEYAACFHTFINALRDRTFDKLVLSRHLTVDKVADFSPLSIFRAACKRYIHSY
                     IYLCYTPQTGIWLGSTPEIILSGEKDEWHTVALAGTQPLQDGRLPQVWDEKNRKEQDYV
                     ASYIRRQLLSLDIHSTENGPYPAYAGALSHLKTDFRFSLKDNKGLGDLLKVLHPTPAVC
                     GLPKEEAYQFILQNEGYDRRYYSGFIGWLDPEGRTDIYVNLRCMHIEDKQLTLYAGGGL
                     LASSELNDEWLETEKKLQTIKRLIAVPPLKS"
     CDS             complement(4063..5295)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_4"
                     /sec_met_domain="HBT (E-value: 7.9e-18, bitscore: 56.5,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLASGR
                     PTYGLMPLAKMLELGNYGGFILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARKNG
                     FALFTYHDDTIITDSPENEHIQNEARLNNLQIIKEEEFSAAVDFAPCKCMLVSDDEEAL
                     VGLEDHWKRRLNGALDVFRSEPYFLEVVPCAIDKANSLGALLEVLDVKREEVIAVGDGV
                     CDVTMIQLAGLGVAMGHSQDSVKACADYVTASNEEDGVAVAVEKAIIAEVRAAEIPLDQ
                     LNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALAETVAGLGS
                     MILCQPDEIVVGMQVSGNHISSAHEGDTVRAVGTVVHKGRSSHVWNVDVFTSTNKLVSS
                     IRVVNSVMKKR"
     CDS             complement(5380..5742)
                     /locus_tag="ctg7_5"
                     /transl_table=11
                     /translation="MIQVRIKRVYDDFSETDGYRVLVDKLWPRGMKKEWLKYDYWAKDI
                     TPSSTLRRWFHEDIPGHWEDFVIQYQKELDASSSMADFLTLIKPHPVITLLYASKEPVY
                     NHARILRDYLEMRLKE"
     CDS             complement(5808..7565)
                     /locus_tag="ctg7_6"
                     /transl_table=11
                     /translation="MRFFVCILVLLFVHNQFSRADKTLTDDSLYTEKYIRDIYIPEPRR
                     ALQLLDEAEDRKTIPLRVVNELRSLSYSNMYMNKLAFMYARKAYLLDSLYQKDPKHMLK
                     MTVHLAEFSAMMSKYNESMRYALDGIRQAQELGNREAKARLFFCMGENNWRLSFKDKAY
                     DYFNRTIELLRGSKEMREMMLLSYYYGAEMSFLMNDSRIDEALKVGFEREKQIKRLKEV
                     PQISEDYVDGQYSYLYAKLAYIYCMEKKYEKAEQYYQKYLSKKESHTPDGKMYSVPYLA
                     LSGQYEKVIDNCRGFKELMRTQQDTLNEQYLTVLRQEVKAYLGMHKYKEAAEIRETILT
                     ITDSINTRDRNNAALELNAMYGASEKEEYIAEQAFQLKIRNITLCFLACIVVLTLFIVW
                     RLWHFNHIVEYKNRMLARLINEKFANRKDGNQLSEVYEQLAVVSEIEPERISPEELEEL
                     ANDTDKESGEEEENKKIFQELNDIVIRKQLYLSSELSREDLAQIVHLNNARFARMIREC
                     TGTNFNGYINELRINYAIELMKKHPNYTIRAIADEAGFNSTPILYNLFKKKTGMTPYEF
                     KKAQDSLQN"
     CDS             complement(7720..8487)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acetyltransf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_7"
                     /sec_met_domain="Acetyltransf_1 (E-value: 3.2e-07,
                     bitscore: 22.4, seeds: 223, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METNYITLTKENIADEHICCAFSDKKCKDSYELKKAWLKKEFDNG
                     YVFRRIDERAKVFIEYGPAEKAWVPVSAPNYLMINCFWVSGKYKGCGHGKALLQSAIDD
                     AKLQGKDGLVTVVGTSKFHFMSDTKWLLRQGFQTIEKLPYGFSLLALKINPAAPDPSFN
                     DSVLTGECPDRDGIVVYYTHRCPFTEFHVRGSLVNAAKSKDLPLKIIELETMEQAQNAP
                     TPATIFTLFYNGKFVTTDLSVCIEARLGKALGL"
     CDS             complement(8537..9472)
                     /locus_tag="ctg7_8"
                     /transl_table=11
                     /translation="MAQKGELHIRNKHNGQYDFPLLIEKYPPLKRFVSLNPLGVQTINF
                     FNPQAVKALNKALLISYYGIRYWDIPKQYLCPPIPGRADYIHYIADLIQPDRVANDLQT
                     EEEDANEQKTKCRCLDVGVGANCIYPIIGHTEYGWTFVGSDIDPVSIENARKIVTCNPV
                     LAHKIDLRLQKDSQKIFDGIIMPGEYFDVTICNPPFHSSKEEAEDGTLRKLSSLKGMKV
                     KKVQLNFGGSANELWCEGGEIRFILNMISESQKYQKNCGWFTSLVSKEKNLEKLCAKLK
                     SVNVSEYKIIRMQQGTKSSRILAWRFSNNS"
     CDS             9865..12366
                     /locus_tag="ctg7_9"
                     /transl_table=11
                     /translation="MIYPQNFEQKIGFDQIRQLLKDKCLSTLGEERVTDMTFSEQHEEV
                     EEKLNQVTEFVRIIQEEDGFPDQFFFDVRPSLKRVRIEGMYLDEQELFDLRRSLETIRD
                     IVRFLHRNEDEEENDTPYPSLKRLAGDIAVFPQLIGKIDGILSKYGKIKDNASTELARI
                     RRELASTMGNISRSLNSILRSAQSEGYVDKDVAPTMRDGRLVIPVAPGLKRKIKGIVHD
                     ESASGKTVFIEPAEVVEANNRIRELEGDERREIIRILTEFSNILRPSIPEILQSYEFLA
                     EIDFIRAKSYFAIQTNSLKPAVENEQLLDWTMAVHPLLQLSLAKHGKKVVPLDIELNQK
                     QRILIISGPNAGGKSVCLKTVGLLQYMLQCGMLIPLHERSHAGIFSSIFIDIGDEQSIE
                     DDLSTYSSHLTNMKIMMKSCNERSLILIDEFGGGTEPQIGGAIAEAVLKRFNQKGTFGV
                     ITTHYQNLKHFAEDHEGVVNGAMLYDRHLMQALFQLQIGNPGSSFAVEIARKIGLPEDV
                     IADASEIVGSEYINADKYLQDIVRDKRYWEGKRQTIRQREKHMEETIARYQTEMEELQK
                     SRKEIIRQAKEEAERMLQESNARIENTIRTIKEAQAEKEKTRQARQELTDFRTSLDALA
                     SKEHEEKIAQKMKKLKEKQERKKNKKNEPKAAVSSPSSAPKVVPIAVGENVKIKGQTSV
                     GQVMEINGKNATVAFGSIKTTVKIDRLERTNNAPKTEGIAKSTFVSSQTHDQMYEKKLS
                     FKQDIDVRGMRGDEALQAVTYFIDDAILVGMDRVRILHGTGTGILRTLIRQYLATVPGV
                     SHYADEHVQFGGAGITVVDFD"
     CDS             12453..13505
                     /locus_tag="ctg7_10"
                     /transl_table=11
                     /translation="MKNNLLSEKLIYTGDSLTPTHLHLCTYNATEMQESANDTFQAIKG
                     TLNSDRINWLQIHGMKDTETIREICSHFEIDFLVLQDILNADHPTKIEEHDKYIVLILK
                     IFYPNEHKEEDELDELLQQQVCLILGNNYVLTFLEKETDFFDDVSSALRNDVLKIRSRQ
                     TDYLLSVLLNSIMGNYISTISSIDDALEDLEEELLTITSGDDIGIQIQALRRQYMLMKK
                     SILPLKEQYIKLLRAENLLIHKVNRAFFNDVNDHLQFVLQTIEICRETLSSLVDLYISN
                     NDLRMNDIMKRLTIVSTIFIPLTFLVGVWGMNYKWMPELEWQYGYLFAWIVMAIIGIIV
                     YLYFRKKKWY"
     CDS             13525..14733
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_beta"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_11"
                     /sec_met_domain="SDH_alpha (E-value: 2.7e-83, bitscore:
                     271.3, seeds: 645, tool: rule-based-clusters)"
                     /sec_met_domain="SDH_beta (E-value: 4.9e-22, bitscore:
                     70.7, seeds: 368, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSIKELYRIGTGPSSSHTMGPRKAAEMFLERHPDAASFKVTLYG
                     SLAATGKGHMTDVAIIDTLQPTAPVEIVWQPKVFLPFHPNGMTFAALDSNDKVQENWTV
                     YSIGGGALAENNDNPTIESPDVYGMENMTEILQWCEDTGKSYWEYVKECEEEDIWDYLA
                     EVWATMKDAIHRGLEAEGVLPGPLNLRRKASTYYIRATGYKQSLQSRGLVFSYALAVSE
                     ENASGGKIVTAPTCGSCGVMPAVLYHLQKSRDFSDMRILRALATAGLFGNIVKFNASIS
                     GAEVGCQGEVGVACAMASAAANQLFGGSPAQIEYAAEMGLEHHLGMTCDPVCGLVQIPC
                     IERNAYAAARALDANLYSAFTDGMHRVSFDKVVQVMKQTGHDLPSLYKETSEGGLAKDY
                     KQM"
ORIGIN
        1 tggcataaaa catccttatc ccacattcct tgttctttct ctacttgccg acaaaatctt
       61 tttaatatat cttcgtaatc aggaagatcg tcacaactta aagcgggcaa aggtgcacac
      121 tcccctattc ccactctgcc agggaagtca ggagaggtaa aatgaagata ccaaacttta
      181 cgcgtagtat atgttcctct ggaagtcccg gcaggttgct tgaaatggag caatcgggga
      241 ataatttcta ttttacaatt catcgtgaat aatttttcaa ttcaccacag aataacacag
      301 agcctcacga agttttaaca agttatatct cttgcagttc tcctaccatt ctctcctcca
      361 cagtcttgct ttgcagaaaa tcgggcttaa acgcaggaaa agcaaactct gtggtactct
      421 gtggcaaagc cgattttaag ggaatttcgg atattgtttg aagttcggtt tacgtttctc
      481 cagaaacgca ttctttcctt cctgtgcttc atcagtcagg taatagagca acgttgcgtc
      541 acctgccaat tcctgaatac ctgcctgacc atccagttcg gcattcaatc ctgctttaat
      601 catgcgcaaa gccaacggac taagcagcat catttcttct gcccactgca catattcatc
      661 ttccaactgc tccaagggaa ctactttatt cactaatccc atatccaatg cttcttgtgc
      721 attatacttc cggcagagga accagatttc gcgtgctttc ttctgaccga ccacacgtgc
      781 cagataagac gcaccgaatc cagcatcaaa gctacctaca cgaggacccg tctgaccgaa
      841 aatagcattt tccgacgcaa tggacaaatc acataccaca tgaagcacat gtccgccacc
      901 aatagcaaaa ccgttcacgg cagcaatcac cggtttcggg atgctgcgaa tctgcttttg
      961 cacatccaat acgctaagac gaggcacacc gtcttttccg atatatccgc cacgtccttt
     1021 cacattctgg tcgccgcccg aacaaaatgc cttatcaccg gctccggtaa tcacaatcac
     1081 atcaatatcc gcttcttcac ggcagatgcg caatgcgtca ctcatttcag cagtagttgt
     1141 cggagtaaac gcattccgat agcgttcacg gttgatcgtg atacgggcaa ttccattata
     1201 ataatcaaaa agaatatcgt cgtattctct aatggttgtc cactctcttt gtgttgacat
     1261 aatctatttt tgttttaatt gatgataata attcttcaac atgcgcgcgt ccttgttttt
     1321 gttggtaaac acctccaaga gcacaggctg ttccatagct tccggttgag tgaaagtttt
     1381 catcgcttca gccagttctt cgtcattttg tgcttgcaga tagaggaatc cacgttcctc
     1441 cgcccaacct ttggccgacg ttttatggac tgccgcaata aatttatgtg aggtacccga
     1501 catatccaat cccggcaagg tatggaaaat ctctcctcct ccattattta acagaagaac
     1561 acgcagattg gagcgaacat tgacattcca caatgcattc atatcataga aaaagctcaa
     1621 atctccgata gctataaagt tcagtttgtc ggaagctgcc gcataaccga cagccgtaga
     1681 cagtgagcct tcaatgccgt ttgtcccccg gttgcaacaa acttcaatcg tagaaggaat
     1741 ggagtataat tgcgcataac gcaccaccga actgtttgcc agatgcaacg cacatgactc
     1801 cggcaaggct ttcaataacg taccgacggc agacatttcc gaataagcaa actccggttc
     1861 gggaatgatc ttgcaatagt tttcccacac acggggatat tcaggagtcc gattgtccag
     1921 caaactggct atcttctcca gaaactcgaa cgggtccatt tcgatcaccg tagttaatga
     1981 gccgtacaaa tcgaccacct caccatccgg cgatacgtgc caatgttctt taggcggatg
     2041 ctgacggaga aacttcttca gccgtttgga aacgacatgt cctccataag taatcaacaa
     2101 ctccggaacc atctggccga ccttctcttc gggcatggca taaagcgccg catcaaagtt
     2161 ctttaccgga ataccgggaa ctgtctggtt gccgatatgt tcagtcaacc aggcaaaatg
     2221 tttatataat aacttgatat atcttttttc aaacaggtag ataagattca tctgaccgat
     2281 gataatcatt cgcttctggt atttattcat ccgatcgacc aaatcattat aatcacgatc
     2341 gtagacgttc aacccctgat aacgggtaat gacacgcact tcaggaagcg aatcaaccgt
     2401 aaactggaac aacggttcag aaatagggac attaatatgt accggtcctt ttccatgatg
     2461 gttcgtttcc agcaaagctt cattcaccag acgattgcaa taccattcat cttcttccgt
     2521 atgaatctcc ggaaggttta ctgacttctt aaccaatgtc tgaaatacgc ctggttgtgg
     2581 tactgtctgt ccatccatct gcccgatcca ggcagcggga cgatccgcag aaataatgac
     2641 cagaggaaca ttttgataaa atgcttctgc cacagccgga tgaaggttta ataatgcagt
     2701 accggaagtg caacagacag ctgcgggctt accaccattc aacgcaagac cgatggcaaa
     2761 atagccggca ctccgttcat ccgtcaccgg atagcaggta aaattcggat ggttagacaa
     2821 agtatgtact atgggcgtat tacgactacc cggacacaat acaaccttag taatcccatg
     2881 cgcctcgagc aacgcaacca actggagtat gttcttcttg tctgtataca tgatgataat
     2941 tattagtagt ttatgatttt aaaggaggca ctgcaatcag ccgtttgatg gtttgcaact
     3001 tcttctccgt ttccagccat tcgtcattca attccgaaga ggccaataat ccaccgccgg
     3061 cataaagagt aagttgttta tcttcgatat gcatacagcg taagtttaca tagatgtctg
     3121 ttcgtccttc cggatcgagc catccgataa agccggagta atagcggcgg tcgtaacctt
     3181 cattctgcaa aataaactga taggcttctt ccttcggcaa gccgcatacg gcaggtgtcg
     3241 gatgcaaaac tttcagaagg tctcccaaac ctttattatc tttcaaagaa aaacggaaat
     3301 cagtttttaa atgtgacaaa gcaccggcat aagcaggata tggcccgttt tccgtagaat
     3361 gaatatccag tgaaagaagc tgccgacgga tataagaagc aacataatct tgttctttcc
     3421 ggttcttttc atcccatact tgcggcaatc tgccatcttg caaaggctgt gttccggcta
     3481 gtgcaaccgt atgccattcg tctttctcac ctgataaaat gatttcggga gtacttccca
     3541 gccagatgcc cgtctgcgga gtataacata agtaaatata cgaatgaata taacgtttac
     3601 aagccgcccg aaagatggac aaaggagaaa aatccgcaac tttatcaact gtaagatgac
     3661 gggaaagcac tagtttatca aacgtcctgt cacgtaacgc atttataaag gtatgaaagc
     3721 atgccgcata ttcttccgta gaagaagtca gaaatgattc ttgtccttgc aggcgcaagg
     3781 ctatctcccg atcttcttcc gtatcatcat ccacgggtaa aggctgcccc cactgatcgg
     3841 gttgaatcaa cacaaccgga catgactcac tcacctgaaa cggagcaatt acaaatcctc
     3901 tctgtccatt cagttctttc aaatcgtata tcaaacggac cgctccttcc gcctgcgtca
     3961 acagacgggg aactttctct ccgggaatac ggtaaacagc aaacggctgc ttccgctgaa
     4021 taaatgcatc aatagttgtc aagttactta tttcttcgtc ggtcatctct ttttcatcac
     4081 actgttgact acccgtatgg aagacaccag tttgtttgtt gaagtaaaca cgtctacatt
     4141 ccatacgtgg gaggaacgtc ctttatgtac aactgttcct actgcacgca cggtatctcc
     4201 ttcatgtgca gaagatatat ggtttccgct gacctgcatt cctactacaa tctcgtccgg
     4261 ctggcaaaga atcatcgaac cgagtccggc aactgtttcc gccaacgcaa gagtagctcc
     4321 accatgcaaa atgccaaaag gctgacgggt acgatggtct accggcatcg ttgcttccac
     4381 acgatcttcg tcggcgtatg tatattgaat tcccaagttt cccattaatg cgtggcgtgc
     4441 ctgcgcattc agttggtcaa ggggaatttc ggctgcacgc acttcggcta tgatagcttt
     4501 ctccactgca acggccactc cgtcttcctc attcgaagca gtcacatagt cggcacaggc
     4561 tttgaccgag tcttgtgaat gtcccatagc tacacccagc ccggccaact gaatcattgt
     4621 tacatcacac acaccgtcgc ccacagcaat cacttcctca cgcttcacat ccagcacctc
     4681 cagcaaagca cccaaagaat tggctttgtc gatggcgcag ggaactactt ccagaaaata
     4741 tggctccgaa cggaatacgt ccaacgctcc gttcaatcgt ctcttccagt gatcttccag
     4801 accaaccagt gcttcttcgt catcgctcac cagcatacac ttacaaggag caaaatcaac
     4861 ggcagcagaa aattcttctt ctttaattat ttgcaggtta ttcaaccggg cttcattttg
     4921 gatatgttca ttttcaggag aatccgttat gatcgtatca tcatgataag tgaataaggc
     4981 aaaaccgttt ttacgggctt tcttttccag atacggcaac atttcgggat taatccgacg
     5041 ttcaaacaga atttccccgt tttgtgcatt gataatctga cagccattat aggaaaggat
     5101 aaaacctcca tagtttccaa gttcaagcat cttggccagc ggcatcaggc cataagtagg
     5161 tctgccggat gccagcacaa tacgtactcc catttgctga accttcaaca gggcagccaa
     5221 tgtacgctta ctaatttctt tcgcatcatt gaggagtgtt ccgtctacat caagaaccaa
     5281 taatttatac ttcatgatta cacgattttg atttagatta caaaggtagg aaattgagtg
     5341 aacgacagaa agcgtaaaca gataaaaatt actttaattt cactctttca aacgcatttc
     5401 cagataatcg cggaggatac gggcatgatt atacaccggt tctttggaag cgtaaagcaa
     5461 tgttatcacc ggatgcggct tgataagagt cagaaaatca gccattgagg aagaagcgtc
     5521 aagttctttc tgatactgta tgacgaagtc ttcccagtgt ccgggaatat cttcgtgaaa
     5581 ccatctacgc aatgtggaag acggtgtgat gtcttttgcc caataatcgt acttaagcca
     5641 ttctttcttc attccacgtg gccataattt atctaccagt acccggtagc catctgtttc
     5701 tgaaaaatcg tcgtaaaccc gctttatcct tacctgtatc atttctatta atagttaatt
     5761 ataaatagat aaaccggaaa atgcgaaaat tgtttagcag aatccactca attctgtaac
     5821 gaatcctgtg cttttttaaa ttcgtaagga gtcattcccg tctttttctt aaaaagattg
     5881 tataaaatcg gggtgctatt aaatccggcc tcatccgcaa tggcacgtat cgtataatta
     5941 ggatgctttt tcatcagttc aatggcataa ttaatgcgca attcattgat atatccatta
     6001 aaattggttc cggtacattc tcttatcatc ctcgcaaaac gtgcgttatt cagatgtacg
     6061 atttgtgcca gatcttctct cgacaattct gaagaaagat ataactgttt ccgaataacg
     6121 atatcattca gttcctgaaa tatcttctta ttctcttctt cttccccact ttctttatct
     6181 gtatcgttag caagttcttc cagttcttcg ggtgaaatac gttccggttc aatctccgac
     6241 acaacagcca gttgttcgta tacttccgat agctggttcc catcttttct attagcaaat
     6301 ttctcgttta taagcctggc aagcatcctg ttcttatatt cgactatatg attgaaatgc
     6361 cacaaacgcc aaacgataaa cagagtcaac acaacaatac acgcaagaaa acagagggta
     6421 atatttctta tttttaattg aaaagcctgt tcggcaatat attcttcttt ttcagaagcg
     6481 ccgtacattg cattcaattc caatgcagca ttgtttctat cccgggtatt gatactatct
     6541 gttatagtta aaatcgtttc acgtatctcg gcagcttctt tgtatttatg catacccaaa
     6601 tatgccttca cttcctgtcg aaggacagtc agatactgtt cattcaaagt atcctgctgg
     6661 gttctcatca attccttgaa ccccctgcaa ttatcaataa ccttttcata ttgtccggaa
     6721 agcgccaaat aaggaaccga gtacattttt ccgtcgggag tatgagactc tttctttgat
     6781 aagtatttct gataatattg ctccgccttc tcatatttct tctccatgca atagatgtag
     6841 gctaatttgg catataaata actatattgg ccatctacat aatcttcaga gatttgaggt
     6901 acttccttaa gccgtttaat ctgcttttca cgctcaaaac ccactttcaa tgcctcatca
     6961 attcgagaat cattcattaa aaagctcatt tctgctccat agtaataaga gagcagcatc
     7021 atttcccgca tctcctttga gccccgcaaa agctcaatag tccggttaaa ataatcgtat
     7081 gctttatctt taaaagataa tctccaatta ttctccccca tacagaaaaa taacctggct
     7141 ttggcttccc tgttccctaa ttcttgcgcc tgcctgattc catctaatgc ataacgcata
     7201 ctttcattat atttactcat cattgccgaa aactcagcca aatgtactgt cattttcagc
     7261 atgtgtttcg gatctttttg atatagagaa tcaagcaaat aagctttcct tgcatacata
     7321 aatgctagtt tattcatata catattacta tatgataaac tacgcaattc atttacaacc
     7381 cgcaaaggaa tcgttttcct gtcctccgct tcgtccagta attgcagagc acgcctaggt
     7441 tcgggaatat aaatatccct gatatatttc tccgtataca gagaatcatc tgttaaagtt
     7501 ttatcagccc tcgaaaattg attatgtaca aataaaagca ccaaaataca tacaaaaaaa
     7561 cgcataagtt cttaccgtat tttaatcatt caacatccaa agatatgtat tttccataaa
     7621 aagtgcaagg tacatcttaa ttttgcaaaa ttaaaataag aaacattagc tatcttctta
     7681 tcccaatcct agtttctgat aaatcttcat ctcacagaat cacaagccta aagcctttcc
     7741 caaccgggct tcaatacaca cgctcaaatc ggtcgtaaca aacttaccat tataaaaaag
     7801 agtaaagata gtggctggag taggcgcatt ttgtgcctgt tccatggttt ctaattctat
     7861 tatttttaat gggagatcct tgctcttggc tgcattgacc aaagaaccgc gaacatggaa
     7921 ttcagtaaac ggacaacgat gagtataata cactactatt ccatcccggt caggacactc
     7981 acctgtcaag acactgtcgt tgaatgaagg atcgggagca gccggattta ttttcaaagc
     8041 caacaaactg aatccgtaag gaagtttttc tatagtttgg aaaccttgtc gcagcagcca
     8101 ttttgtatca ctcataaaat gaaatttaga agtgcccact acggtaacta aaccatcttt
     8161 tccctgcaat ttcgcatcat caatagcaga ctgcagcaaa gccttaccat gcccgcatcc
     8221 tttatattta cccgacaccc agaaacaatt tatcatcaga taattaggag cactgacagg
     8281 aacccacgcc ttttcagcag gaccatattc gatgaacact ttcgcccgtt cgtcaatacg
     8341 tctgaaaaca taaccattat caaactcttt tttcagccat gcttttttta actcataact
     8401 atctttgcat ttcttatccg aaaaggcaca gcatatatgt tcgtccgcaa tattctcctt
     8461 cgtcaaagtg atgtaatttg tttccataat attatattaa taggtttaaa aataacaaat
     8521 cgataagcac tcattattat gagttattag aaaatcgcca ggctaatatt ctgctgcttt
     8581 tagttccctg ctgcattctg ataatcttat attccgatac attcacagac ttcaatttag
     8641 cacatagctt ttcgagattc ttttcttttg aaaccaagct ggtaaaccat ccacagttct
     8701 tctgatattt ctgactctcg gagatcatat tcagtataaa acggatttct ccaccctcac
     8761 accaaagttc attcgcactc ccgccaaaat ttaattgtac ttttttcacc ttcatccctt
     8821 tcaggctact caatttgcgc aaggttccgt cttccgcttc ttccttcgag ctatgaaacg
     8881 gagggttaca tatcgtaaca tcaaaatact cgccaggcat gataattcca tcaaaaattt
     8941 tctgactgtc tttctgaagt cgcaagtcaa tcttatgtgc caataccggg ttgcaagtca
     9001 ctatctttcg tgcattctca atcgagaccg gatcaatatc actgcccaca aatgtccatc
     9061 catattctgt gtgccctata atcggataaa tacaatttgc acctacccca acatccagac
     9121 atctgcattt cgttttctgt tcgttcgcat cttcctcctc tgtctgcaaa tcgttcgcta
     9181 ccctatccgg ctgaataaga tcggcaatat aatgaatata atccgctctt ccaggaatgg
     9241 gtggacacaa gtattgtttc ggtatatccc agtaccgaat gccataataa ctgattaata
     9301 atgctttatt taaagctttt actgcttgcg gattaaaaaa gtttatagtt tgtacaccca
     9361 gaggattaag tgatacgaat ctcttaagtg gaggatattt ttctatcaac aacggaaaat
     9421 cgtattgacc attgtgctta tttcttatat gtaactcacc tttttgtgcc atgccggcaa
     9481 agatacagag aattttcctg tctgcaaatt ttccctgtta atacactaaa ttggaatcaa
     9541 atcaccccaa aatatcataa aataaaaaag catcccataa ggtcattttc tgaaacctta
     9601 attaggatgc ttattctata atgcattgat attcaatgct taaaagcgga gagacaggga
     9661 ttcgaacccc gggtacctcg cagtacaacg gttttcaaga ccgccgcaat cgaccactct
     9721 gccacctctc caaaactcct ttatcagaag tgctttccgt tgaaagcggt gcaaaggtac
     9781 gaatcatttt taaatctgca aacattctga tatttttttc gcgaattaat cgtatttttg
     9841 cagtccatta gtaagaacaa agatatgata taccctcaaa attttgagca aaagatagga
     9901 ttcgaccaga tcaggcagtt actaaaagat aagtgtctta gcactttagg cgaagaaaga
     9961 gtcacagaca tgaccttttc ggagcaacat gaagaagttg aggagaaatt aaaccaggta
    10021 acagagtttg tccgcatcat ccaagaagaa gatggatttc ccgatcaatt tttctttgat
    10081 gtccgccctt cactaaagcg agtgcggata gaaggaatgt atctggacga gcaagaacta
    10141 ttcgacctgc gccgttcgtt agaaaccatc cgtgacattg tacgctttct ccatcgaaat
    10201 gaagatgaag aagagaacga caccccctac cccagtctga aacgactggc aggagatata
    10261 gccgttttcc ctcaactgat aggaaaaata gacggtatcc ttagcaaata tggaaaaatc
    10321 aaggataatg cttccaccga attagcccgt atacgtcgcg agcttgccag tacaatggga
    10381 aatatttccc gctcgttaaa cagcatcctg cgcagcgcac aatccgaagg atacgtagat
    10441 aaagacgtag ctcccaccat gcgtgacgga cgtttggtga tccccgtcgc acccggactc
    10501 aagcgaaaaa tcaaaggtat tgtacacgat gaatccgcta gcgggaaaac agtgtttata
    10561 gaaccggcgg aagtcgtaga agccaacaac cgtattcgcg aactcgaagg cgacgaacga
    10621 cgcgaaatta ttcgcatcct taccgagttt tcaaacattc tccgtccgtc tatcccggaa
    10681 atccttcaat catacgaatt tctggcagaa atagatttta tccgcgcgaa aagctatttc
    10741 gccatacaga ccaatagtct gaaacccgcc gtagagaatg agcaactact ggactggaca
    10801 atggctgtac atcctttatt acaactttca cttgccaaac acggaaagaa agtcgtacca
    10861 ctggatatag aactgaatca aaaacaacgt attcttatta tatccggtcc gaatgccgga
    10921 ggtaagtccg tctgcctcaa aacagtcggt ttactgcaat atatgttgca atgcggtatg
    10981 ctcattccct tgcacgaacg cagtcacgcc ggtatattca gcagcatctt tatcgatatt
    11041 ggtgatgagc aatctattga agacgatttg agtacctact cttctcacct gaccaatatg
    11101 aaaatcatga tgaagagttg caacgaacga agcctcatcc tgattgacga gttcggtgga
    11161 ggtacggaac cgcaaattgg aggtgctatt gccgaagccg tcctgaaacg tttcaaccag
    11221 aaaggaacat tcggagtcat caccacccac taccagaatc tgaaacattt tgccgaagat
    11281 catgaaggag tagtgaacgg agccatgctt tacgaccgcc atctcatgca agcacttttc
    11341 cagctacaaa tcggaaatcc cggaagttcg tttgccgtag aaatcgcacg aaaaatcgga
    11401 ttaccggaag atgtcattgc agatgcttcg gaaatcgtag gaagtgaata tatcaatgcc
    11461 gacaaatacc ttcaggacat cgtgcgcgac aagcgttact gggaaggaaa acgtcaaact
    11521 atccgtcaac gggaaaaaca catggaagaa accattgccc gctaccaaac ggaaatggaa
    11581 gagttgcaga aatcacggaa agagatcatc cggcaagcaa aagaagaagc ggaacggatg
    11641 cttcaggaat ccaatgcacg cattgaaaat acaatacgca caatcaagga agcacaagct
    11701 gaaaaggaaa agacacgcca ggcacgtcag gaactgacag acttccgtac ttctttagat
    11761 gcgctggctt ctaaagagca tgaagagaag attgcacaga aaatgaagaa attaaaggag
    11821 aaacaagaac ggaagaaaaa taagaaaaac gaaccgaaag ccgcagtctc ttccccgtca
    11881 agtgctccta aagtagtgcc gattgcagta ggtgaaaatg taaaaatcaa aggacagaca
    11941 agtgtcggcc aagtgatgga aatcaatggt aaaaatgcga ccgttgcttt tggaagcata
    12001 aaaacgaccg taaaaataga ccgtttggaa cgtaccaata acgcacccaa gacggaagga
    12061 atcgccaaaa gcacctttgt cagtagccag acgcatgacc aaatgtacga aaagaagctt
    12121 agcttcaaac aagacatcga tgtgcgtgga atgcgcggag acgaagctct gcaagcagtc
    12181 acctatttta tcgatgacgc catattagtc ggcatggacc gtgtacgcat ccttcacggc
    12241 acaggaacgg gaatacttcg tacattaatc cgccagtatc tggccaccgt accgggagtg
    12301 agccactatg ctgacgaaca tgtgcagttt ggcggtgccg gaatcacagt agtcgatttt
    12361 gactaacctg taaacaaaac gtccaaagaa cttgttctca tttagaaaac cactaccttt
    12421 gttacagtgg ttttctaaaa cgagaataaa gcatgaagaa taatctgtta agcgaaaagc
    12481 ttatttacac aggagacagt cttactccta cccacttaca tctttgtact tacaatgcta
    12541 ccgagatgca ggaaagcgcc aacgacacct ttcaagccat caagggaaca ctgaacagcg
    12601 atcggatcaa ttggctacaa atacacggaa tgaaagatac ggagactatc cgggaaattt
    12661 gcagtcattt tgaaatagac ttcctagtcc tgcaagatat actgaatgcg gatcatccta
    12721 ccaagataga agagcacgac aaatacatcg tcctgatctt aaaaatattc taccccaacg
    12781 aacataaaga agaagacgaa ctggacgagt tgctccaaca acaagtctgt cttattctag
    12841 gtaataacta cgtacttact ttcctcgaaa aagaaaccga cttcttcgat gatgtcagtt
    12901 ccgctctgcg caatgatgtc ctgaagatac gtagccgcca gactgattat ctacttagcg
    12961 tgctactcaa cagtatcatg ggaaactata tttcaacaat ctcttccatt gatgacgcac
    13021 tcgaagattt ggaagaagaa ctgctcacca tcaccagcgg tgatgacatc ggtattcaga
    13081 ttcaggcatt acgacgccaa tatatgctga tgaaaaaatc tatccttcca ctaaaagaac
    13141 aatatataaa gttactacgg gcagaaaacc tgcttattca caaagtgaac cgtgcctttt
    13201 tcaatgatgt aaacgaccac ttgcaatttg tattacagac cattgagatc tgccgggaaa
    13261 ctctttcctc attagtcgat ctgtacatct ccaacaatga tttacgtatg aacgacatca
    13321 tgaagaggtt aaccatcgta tccaccatct ttatcccttt gacatttctg gtcggagtat
    13381 ggggaatgaa ttacaaatgg atgcccgagc tcgaatggca atacgggtat ttatttgcct
    13441 ggattgtaat ggcaattatc ggtattattg tatatttgta cttcagaaaa aagaaatggt
    13501 attaacaaaa acacatcatc agtcatgaaa tcgataaaag agctatatag aataggcaca
    13561 ggaccttcca gtagccacac tatgggaccg cgtaaagctg ccgaaatgtt tctggaacgt
    13621 catccggatg ctgcatcttt taaagtaacc ctttacggca gtttagctgc tacaggcaaa
    13681 ggacacatga cggatgtagc cattatagac actttgcaac ccactgcccc ggtagaaatt
    13741 gtgtggcagc ccaaagtctt tctaccgttc catccgaacg gaatgacatt tgcagcttta
    13801 gatagcaacg ataaagtgca ggagaattgg actgtttata gcatcggtgg tggtgcacta
    13861 gcagaaaata atgacaatcc aaccatcgaa agccccgatg tatatggtat ggaaaacatg
    13921 actgaaatac tccaatggtg tgaagatacc ggaaaaagtt attgggaata cgtaaaggaa
    13981 tgtgaggaag aagatatatg ggactacctg gctgaagtat gggctaccat gaaagatgcc
    14041 attcaccgtg gactcgaagc agagggcgta ctacccggac cactaaatct ccggcggaaa
    14101 gcctccactt attacatacg tgctaccgga tacaaacaat ccctgcaatc cagagggctc
    14161 gtcttctctt atgctttggc agtaagtgaa gaaaatgctt ccggcggtaa aatagtaacc
    14221 gctccgactt gtggttcttg tggagttatg cctgccgtac tttatcatct tcaaaaaagc
    14281 cgtgacttta gcgatatgcg cattttacgt gcgttagcca ctgccggttt gtttggcaac
    14341 atcgtcaaat tcaacgcatc catttccgga gcagaagtag gttgtcaggg agaagtcggt
    14401 gttgcctgcg caatggcttc ggctgccgcc aatcaattgt tcgggggcag ccctgcacaa
    14461 attgagtatg cagcagaaat gggcttggaa caccatttgg gaatgacttg cgacccggta
    14521 tgcggattgg tacaaattcc ctgcatcgaa cgaaatgcat acgccgccgc acgtgcgctg
    14581 gatgctaatc tttattcagc tttcaccgat ggcatgcacc gtgtctcttt cgacaaagta
    14641 gtgcaagtga tgaaacagac cggacatgac ctaccgtcac tctataaaga aacaagtgaa
    14701 ggaggattgg ccaaggatta caaacaaatg taattataaa aagcaacgga ccattccttt
    14761 tatagaaatg gtccgttgtc atttttatga ttaaaagtta ttcagttggc ggccaattcg
    14821 tatcgtctcc gttactgata tctttttcat gtatcaatcc accatcctgc gtgaaataaa
    14881 gcgagtagcg ttggctacct tgtttcacct gaatcacaga ttccatcgga ttctgtggaa
    14941 atgttaacac atatacatct gtcactaccc acgcgttata tttagaatcc ataaaagccg
    15001 tataaacagc cggcaccaac tgatcaatac tgttcagttc attttctgtc atcacccagt
    15061 tggcattagt atcaaaccat acttccaatt catcattgct cacccaacag tcagctacat
    15121 aataagcacc tttcatctcc cattctatat tctgggcagc cggatatacc tgtttcaagg
    15181 cctccgtaat attactgggc ggaacaaaag tatcatcatc gtcattatca catgcgccga
    15241 aagaaagggc agtcataagc aacactactg cccatgcgct aaacttaaat ctcca
//
