LOCUS       gnlProkkaENFLOKOM_25   14179 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ENFLOKOM_25.
ACCESSION   gnlProkkaENFLOKOM_25
VERSION     gnlProkkaENFLOKOM_25
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 10:17:03
            Original ID  :: gnl|Prokka|ENFLOKOM_25
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 7510
            Orig. end    :: 21689
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14179
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10351]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10351
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14179
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14179
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2277..3161
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_11"
                     /sec_met_domain="PF04055 (E-value: 1.6e-18, bitscore: 58.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHRELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVY
                     IPDDDRATLCVSSQVGCKMNCKFCMTGKQGYTANLTASQIMNQIHSLPERDKLTNVVMM
                     GMGEPLDNLDEVLKALELLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLH
                     SPLTVQRAELMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLK
                     LLRGLDCRVNLIRFHAIPGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACG
                     MLSTAKQEKNNES"
     CDS             3180..4220
                     /locus_tag="ctg25_12"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKE
                     AEQTNK"
     CDS             4225..5319
                     /locus_tag="ctg25_13"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5329..6570
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg25_14"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(6590..7054)
                     /locus_tag="ctg25_15"
                     /transl_table=11
                     /translation="MVGDLFRHFSNQSVLYGSQQLARVVGTERRKLLFKVFGMIGVVDK
                     TYINGDSQLRLRRITVGRYSLIVLIVTCDFSVNLQVGILTRLEQLQTGLPDEDIFQVLI
                     KLGCQRSIHILRLDREVGYRNGLYLIIIDRRSVKLIGNSARNDYQRQAEQ"
     CDS             7090..7863
                     /locus_tag="ctg25_16"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQPAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             8050..8265
                     /locus_tag="ctg25_17"
                     /transl_table=11
                     /translation="MVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAPQ
                     TEAPATNAPATETPAPATETPAPAAE"
     CDS             8593..9903
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 85.5; E-value: 4.7e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg25_18"
                     /transl_table=11
                     /translation="MLCGYFLTDVMSPLKPMLEKELLWDSLDYGFFTSAYGWFNVFLLM
                     LIFGGIILDKMGVRFTGMGACLLMVFGCGLKYYAISTTFPEGAMLFGFKTQVTLAALGY
                     AIFGVGVEIAGITVSKIIVKWFKGKEMALAMGLEMATARIGTTLAMVLTVPLADFFGST
                     DESGTFHTNIPAPILFCLIMLCVGTIAFFLYTFYDKKLDASLDAEGLEPEEPFRMKDIV
                     YIITNKGFWLIALLCVLFYSAVFPFIKYAADLMVQKYNVDPKLAGTIPGLLPIGAIILT
                     PLFGSLYDRIGKGATLMIIGSVMLIFVHTMFALPILNIWWFATIIMIILGFAFSLVPSA
                     MWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPLLIGWVLNTYCKGPVVDGAQTYDYTL
                     PMAIFALFGVLALIVALMLKAENKKKGYGLEEANIQK"
     CDS             10001..10351
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_19"
                     /sec_met_domain="PqqD_RRE (E-value: 5.8e-11, bitscore:
                     32.8, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.6e-17, bitscore: 53.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYELRVSAYLSQMQ
                     KDGFIKLVIPVV"
     CDS             complement(10370..10654)
                     /locus_tag="ctg25_20"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(10692..11792)
                     /locus_tag="ctg25_21"
                     /transl_table=11
                     /translation="MFSKPVKKEPNMKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGV
                     VYSLPKTQIELEIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVP
                     NSETTYFVKLKDKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPAVLQKKANPREF
                     LTEEILMASSTAKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEE
                     AMTQMFSGTCNKEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDL
                     KSVKMPQEDGKKKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLF
                     NKNSTIKVYFDPNTGGLLKVDREEGK"
     CDS             complement(11833..13344)
                     /locus_tag="ctg25_22"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPAGNPGMATGGSGDVLTGVILALLAQGYST
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWQLVSE"
     CDS             complement(13807..13992)
                     /locus_tag="ctg25_23"
                     /transl_table=11
                     /translation="MLASIHSVLVPHIVGKDSLRLGKVFPYFVGKYSRILKENFPTIYG
                     TIETNEHLQAKSHYFI"
     CDS             complement(14022..14111)
                     /locus_tag="ctg25_24"
                     /transl_table=11
                     /translation="MILKQVFLIVSSQNNPDFASFLIVSCAGS"
ORIGIN
        1 cgctcatttc cagttgaatg gcttttcgca ggcggatgcc aagttgttct caaagcaata
       61 tttgtctact tactccaagg ctttgtccgc acaacaggaa gatattcttg cttcgtgggt
      121 gctggctaaa caaccgcgct gtttaagtgt attgctcaac gagctggttt cgttcggtca
      181 gtacgatgct ctcaatgaat atatgagtgg atattgccgg ctcaatgagg ttgggcaatt
      241 ctatgacagt gtgctacggc gtttgtcggc tgattatggt ttcgaagaga ttggaagaac
      301 gcttctgatg ctttcactta ctttagaagg atttaccgaa gatgaagtga agagcatggc
      361 agacattaat cagatacttt ggtcgcagtt gagagtggaa atgagcagct ggctcactaa
      421 caaaggaggg cgatattgca ttggtgacac acaaatggta gaggcaatcg aacgctattt
      481 cgctcaagat gacgaatgta tagatgatag tcgccatgaa attatttccg ctctgctgga
      541 tgaggaagag atcctttccc atccgttgac ttttgccgat tataactatc gcatgaaaca
      601 gttctgctac catgattcgt atcgctataa agtggagatt acctatcaat gctataagat
      661 gcaagaatgg gatatattga aggattggat ttgtgatgtg gagattttcg agattctgta
      721 tcgcacgaat cgttctctgt tggaagatag ctggaaggcg atcatgaacg acaatcctga
      781 agttacgcct gaagtctatg ccgaattgga ttttgatgag atcgattctt ttttaattcc
      841 tgtcattgct aatgatatgg ctactttctt gagcagttct ttccatctga cgaaggcggc
      901 agctgctgtg agtgagaaga gtatggaagg tgctgccatg ccactcattg ccaagtcggt
      961 attgaagatg aatgagggat gccggtatgc ccgtaatgaa gaatacgaaa cggcatgcga
     1021 ctgtttcctg aaagcattgg tgatgcagga aaacattgta ccgactccgg aactggagat
     1081 tgccaacacc tgtcgaaatc tagctttggc atattactac aatgagcaat acaatgaagc
     1141 ggcgatctat ttgaataggg cgcttgatta tcatgcggct tctgctgacg agaagagtca
     1201 ggcagaagtc attgaacttt ccgaatatct ggcttattgt gattactata aggatgagga
     1261 agagagtgct gccgagaaat tccggaaagt agctgaaatg cacgagtcgt tgaatggcag
     1321 actgtccggt ggagtggcta aatgtttgcg tatgcagggt aaatgtcttt attatatcaa
     1381 acgatacgat gaagcatgga tgctgatgaa tcaggcgttg gacattgcta tacagataga
     1441 cagcaaaaaa cagatcgtcg cttgtcataa acagttgtat tatctatgca gggaattcaa
     1501 acggatgatg aatgaacgtg gcgatgagca ggcgtctact ttattcttcc gtgagtctct
     1561 tctgcatgaa atgtatttca gcgaaaaacc gcgtctggcg gaactgactg tccgctacga
     1621 ggcattgaga tgtgatatta tgcagcagta ttacatgaat aaagactatg ataacgtgat
     1681 tcgtattgca acgtctttgg attttcacga tgatgctgac cctaatgctt cctgtctggt
     1741 atattattac aaagcacagg cttatgtgaa gttggagaat tatccaatgg cgaaagaggc
     1801 tttcttcaga gagcttgaac tgcgaaagaa gtatttggga tgggaggaag aagatacgat
     1861 tctggcttgt cagaacttag gggttttgca cagcttttgt aatgaacggg aagaggcgtt
     1921 ggcttgtttc cgtgaggcgt acggtcatga agtgaaaaag aatggcgagg attctgaaat
     1981 ggcgcaaaag ctacttcaat atatcagcgt ggttgaatca taacggaggc atacttccct
     2041 tttttgttaa cttttacatt cctgctatac ggaaatcgac tttatttcct tacatttgca
     2101 gatataaact atcaacagaa agaagaatgt ctaaatatcc ccttttagga atgactcttg
     2161 tagagcttca atcattgaca aaaagactgg gtatgcccgg ctttgctgcc aagcagattg
     2221 catcctggct ttacgaaaag aaggtagcct cgattgatga tatgactaat ttgtcattga
     2281 aacaccggga gttgctcaag cagaactatg aggtgggagc agaagctccg gtagatgaaa
     2341 tgcgctctgt agatggtacg gtgaagtatc tttataaagt gggtgagaac cattttgtag
     2401 agtcggttta tataccggat gatgaccggg caacgttgtg cgtgtcgtca caagtaggtt
     2461 gcaagatgaa ctgtaagttc tgtatgaccg gtaaacaggg gtataccgct aacctgaccg
     2521 ccagccagat catgaatcag attcattcgc tgccggaacg ggacaaactg actaatgtcg
     2581 taatgatggg aatgggcgag ccgctcgata acctggatga ggtattgaag gcattggaac
     2641 tactgaccgc tacctacggt tacgcatgga gtccgaagcg tatcacgctt tctactgtcg
     2701 ggctacggaa aggattgcag cgttttattg aagaaaacga ctgccacctt gccatcagcc
     2761 ttcactctcc gctgaccgtt cagcgtgctg aattaatgcc ggcggaaaag gcgttttcaa
     2821 tcaccgaaat ggtggaactg ttaaaaaact atgattttag taaacaacgt cgactttcgt
     2881 ttgaatatat tgtttttaaa gggctcaatg attcgcaggt ctatgccaaa gagttgctga
     2941 aacttcttcg cgggctggat tgcagggtga atctgattcg ttttcatgcc ataccggggg
     3001 tagaccttga gggggcggac atggatacga tgacccgttt tcgtgattat ctgacatcac
     3061 acggactttt caccactatc cgttcatcca gaggcgaaga tatttttgcc gcttgcggta
     3121 tgctgtcgac agcgaaacag gagaaaaata atgaaagtta atatataaaa ccgaacatca
     3181 tgaaaaagta ctcttttatt ttatgcatcg ctttggtagc ctttgtcgtt gcatcttgtg
     3241 gtctgaaagg aaatcacacc tctagtggtc gtgcttacga gcttttggtt gtagtagatc
     3301 acggtgtttg ggatcgtgct gccggaaggg ctttacatga tgcgctcgat gctgatatgc
     3361 ccggtttgcc gcagtcggaa ccttctttcc ggattatgta tacttcaccg aaagattatg
     3421 attctacgct gaagttgata cgtaacatta ttattgtaga tatacaggat atatatacga
     3481 aagcctcgtt caaatatgcg aaggacgtgt atgccaatcc gcagatgata ttgactatcc
     3541 aggctccgaa cgaagaagag tttgagaagt ttgtggaaga gaacaaaaag acgattgtcg
     3601 acttctttac ccgtgcggaa atgaaccgtc agattacgtt cctggaaggg aaacacagta
     3661 acttcatttc gcagaaagtg gacagtttgt tcggatgcga catctgggtg gatgccgaac
     3721 tggctaattc aaagaccggg gatgatttct tctgggcttc taccaacaca ggtactgccg
     3781 accgtaactt tgtgatgtac tcttatccgt acactgacaa ggatacgttt accaaagaat
     3841 attttgtgca caaacgtgac tccgtgatga aagccaatat ccccggattc aaggaaggcg
     3901 tttatatgtc gaccgatagt ttgctgaccg atgtccgtcc gatcaatgtg cagaacagct
     3961 acacaatgga agcacgtggc ctgtggcgta tgaagggcga ctttatgggt ggtccgtatg
     4021 tgtctcatac tcgtctggac gagaaaaacc aacgaattat tacagcagaa atatttgttt
     4081 attcacctga taaaatgaaa cgcaacctgg tacgccagat ggaagcatct ctgtatacac
     4141 tgaaacttcc gaatgaagtt cagcagaagc agattccatt gggagaagca tctaaggaag
     4201 cggaacaaac taataaataa aaacatggaa gataacaaga taaggatagg tatcacccaa
     4261 ggagatatta acggggtggg ctatgaggtg attcttaaga cattttccga ccctacgatg
     4321 ttggaactat gtactccgat catttatggc tcaccgaaag tagcggctta tcatcgcaaa
     4381 gcgctggata tacagaccaa tttcagcatt gtcaactctg ctaccgaagc ggggtacaac
     4441 cgtttgagcg ttgtgaactg tacggatgat gaggtgaaag tggaattttc caaacccgat
     4501 cccgaagccg gtaaagctgc gttgggggct ttggaacgtg ccatcgaaga atatcgcgaa
     4561 gggttgatag acgttatcgt aacagctccg atcaacaaac atacgattca gtcggaagag
     4621 ttctccttcc ccggacatac ggaatatatc gaagaacgtc tgggcaatgg tgataagtca
     4681 ttgatgattt tgatgaagaa tgacttccgg gtggctttgg tgacgacaca tatccctgtc
     4741 agagagatcg cgactacgat taccaaagaa ctgattcagg agaaactgat gatattccat
     4801 cgttgcctga aacaggattt cggtatcggt gctccgcgta ttgcggtgct ctctctcaat
     4861 cctcatgccg gagacggtgg tttgttggga atggaagagc aggaagtgat tatccctgcc
     4921 atgaaagaaa tggaagagaa aggaatcctt tgctacggtc cttatgcggc cgacggcttt
     4981 atgggttcag gcaattatac tcattttgac ggtatcctgg cgatgtatca cgatcagggg
     5041 ctggctccgt tcaaggcctt ggctatggaa gacggggtga actatacggc aggactgccg
     5101 gtagtacgta cttctccggc tcatggaacg gcatacgata ttgcaggtaa gggagtggct
     5161 tgtgaagatt ctttccgtca ggcaatctat gttgccatcg acgtgttccg taatcgtcag
     5221 cgggaaaaag tggctcgtgc caatccgttg cgtaaacagt attacgagaa acgtgacgat
     5281 agtgataaac tgaagctgga tacagtagac gaagattaaa aacgagtgat gacgaaagca
     5341 gagatacaac aagtgaaaca gcgtttcggt attattggaa atactgaagc attgtcgcgc
     5401 gccatagatg ttgccattca ggtagctcct accgatttgt ctgtgctgat taccggagaa
     5461 agtggagtcg ggaaagaaag ttttccgcag attattcatc aatatagccg gaggaagcac
     5521 gggcagtata ttgctgtcaa ctgtggtgct attccggagg gtacgattga ttccgaactg
     5581 ttcggacatg agaaaggtgc gtttaccggt gcgattggcg aacggaaagg gtactttggc
     5641 gaagctgacg gcggtactat ttttcttgat gaagtagggg agttgccgat gtctacccag
     5701 gcacgtttgc tccgtgtact ggagagtggc gagtttatga aagtaggttc gtccaaagta
     5761 caaaaaacgg atgtgcgtgt ggtggcggct accaacgtca atctgacaca agcgattgca
     5821 gaaggacgtt tccgtgaaga tttatattac cggttgaata cggtgcctat ccagataccg
     5881 cctttgcgtg aacgtggtga cgatgtgctc ctgttgttcc gtaagttttc cgcagacttt
     5941 gcagagaaat accggatgcc tgctattcag ttgacggagg atgcgaagaa agagttgttg
     6001 gcttacccgt ggccaggaaa cgtgcgtcag ttgaagaata tcaccgagca aatatctatc
     6061 attgaaacca atagggagat ctctgctgct atcttgcaga attatcttcc cgcacaaaat
     6121 acgcaacgtc ttcccgcgct gatgggaacg cgtgagagta aaggctttga gagcgaacgg
     6181 gagattcttt attctgttct gttcgatatg cgccaggaag tggcggagct gaagaagatg
     6241 gtgcacaacc tgatggcgga acgtgccgga caggtggggc aggtaggaca aatgggaacg
     6301 gtggttacta ctccggtagt gacggcgcat caaccttcgg tacctgctat cattcacacc
     6361 atgcagccca cggtttgcaa ggatgatgat gacatacaag acacggaaga atatgtagaa
     6421 gaatctcctt tgtcactgga cgaagtggag aaagaaatga tacgcaaagc acttgagagg
     6481 catcatggaa agcggaagag tgcggccaag gacttgaata tttccgagcg tacactctat
     6541 agaaaaataa aagaatatga attggattaa gaaaataata cgccctttgt tactgttcgg
     6601 cttgccgttg gtagtcattg cgtgcactgt ttcctataag tttaacggat cgtctatcaa
     6661 ttatgataag gtaaagacca tttcgatagc cgacttcccg atcaagtcgg agtatgtgta
     6721 tgctccgttg gcaaccaagt ttaatgagga cctgaaagat atcttcatcc ggcagacccg
     6781 tctgcaactg ctcaagccga gtcaaaatgc cgacttgcag attgacggag aaatcacagg
     6841 ttacaatcag tacaatcagg ctgtatctgc cgacggttat tcttcggaga cgaagttgac
     6901 tatcaccgtt aatgtacgtt ttgtcaacaa caccaatcat gccgaagact ttgaacaaca
     6961 gttttctgcg ttccgtacct acgactctag ccagttgctg actgccgtac aggacggatt
     7021 gattgctgaa atgtctaaag agatcaccga ccaaattttt aatgcaactg tagcaaactg
     7081 gtaatataaa tgacttctgt taactttcaa caatggattc agcatcccga gacgctgaat
     7141 agggatactt tgtacgaact gcgcaatctt cttgcgaggt atccgtattt tcagtcactt
     7201 cgtctgctgt atctgaagaa tctgtatatt ctccatgata ttagttttgg tggagaactg
     7261 cggaaagcag ttctttacat tgcagacaga cggcagttgt tccggttgat tgaaggtgac
     7321 cgctatgatg tgcaggcacg gaaaaaggga gtacctctca cggaggtgct gaaagacgaa
     7381 ccgtccgtag accgcacatt agcattgatc gacgctttct tgtccacagt acccgaagag
     7441 gtgactgccc gcaccagctt cgactattcg atggattaca cctcttatct tttggaggag
     7501 actccggcca cggaacagcc ggccgaagaa acgcccaaac tcaaaggcta cgaactgatt
     7561 gacgacttta tagaaaagag cgagagcgac tctcccctct gcaagaaacc tttaagagaa
     7621 gaaatgccat cttcgccaac ctcttcggac gaacttaccg aagaagaaac gatgaaggaa
     7681 gaagaggaag atgacagctg ttttacggaa actttggcaa aaatctatgt taaacagcaa
     7741 cgatattcaa aagctcttga aataattaaa aaattaagct tgaaatatcc aaaaaaaaat
     7801 gcttactttg cagaccaaat cagatttttg gagaaattga ttattaacgc taattcaaaa
     7861 taactaaaaa tgtacttatt attcgttatc ttaatggtta ttgcagcctt gttgatgtgt
     7921 ttcatcgtgc tgattcagaa ctcaaaagga ggcggacttg cttctggttt ctcttcatct
     7981 aacgccatca tgggcgtgcg caagactaca gattttctgg aaaaagcaac atggggctta
     8041 gctatcttca tggtggtaat gagcattgct actgcttatg tagttcctcg ctctgctgtt
     8101 gctaaagacg cagtgttgga acaggcacag aaagaacaac agactaaccc gtataactta
     8161 cccgcaggta cggctgcgcc gcaaactgaa gctcctgcta ccaatgcacc tgctacagaa
     8221 actccggcac cggctactga aactcctgct cctgcagcag agtaattcac tccgttgtca
     8281 ggtaagactt tggggtaaaa ccattaatgg gaaggtgcag acggatgctg catttctttg
     8341 atatttaagt gcggattacg cagattacac ggattttcaa tcttccgcgt ggtcagtgta
     8401 atccgcactt aactttttct tgtaaaaaca atctcttttt gatagaaaca aacgagattt
     8461 aactaccttt gttggtcgta tgaagattat taactactat ttttaaatat aacaatgaca
     8521 gaacatttga aacagaaatt gaatgactcc gccgtactcc gatggagtgt tctagcattg
     8581 gtcgcattta ctatgctatg cggctatttc ctcaccgacg taatgtctcc tctaaaaccc
     8641 atgcttgaga aagaactact atgggacagt cttgattatg gtttcttcac aagtgcttac
     8701 gggtggttta atgtattcct attgatgctg attttcggtg gtatcatttt ggataagatg
     8761 ggagttcgtt ttaccggaat gggagcttgc ttattgatgg tgtttggttg tggattgaaa
     8821 tactatgcga tttctactac ttttccggaa ggtgccatgc tcttcggatt caaaacacag
     8881 gtaaccctgg ctgcattggg gtatgctatc ttcggtgtag gtgtggaaat tgccggtatc
     8941 acagtttcca aaattatcgt gaaatggttc aagggtaagg aaatggcatt ggctatggga
     9001 cttgaaatgg ctacggcacg tatcggaaca actctggcaa tggtgctcac ggttcctttg
     9061 gccgactttt tcggatctac ggatgagagt ggcacatttc ataccaatat tcctgctccg
     9121 attttgtttt gtctgattat gttgtgcgtg ggtacgattg ctttcttcct ttatactttc
     9181 tatgataaga agttggatgc ttctttggat gcagaaggat tggagccgga agagccgttc
     9241 cgtatgaaag atattgtgta tatcattacc aataaaggat tctggctgat tgcattacta
     9301 tgtgtattgt tctactcggc tgtattcccc tttatcaagt atgctgccga cttgatggtg
     9361 cagaagtata acgtagatcc gaagttggcg ggaacgattc ccggattgtt gccgattggt
     9421 gcgattatcc tgactccgtt gttcggctcg ctttatgacc gtattggtaa gggagccaca
     9481 ttgatgataa tcggatcagt gatgcttatt tttgtgcata cgatgtttgc tctgcctata
     9541 ctgaatatat ggtggtttgc tactatcatc atgattatat tgggatttgc cttctcgttg
     9601 gtgccttcag ctatgtggcc gtctgttccg aagattattc cggaaaaaca gttgggtacc
     9661 gcatatgcat tgattttctg ggtacagaac tggggattga tgggtgttcc tttgttgatc
     9721 ggatgggtgt tgaatactta ttgcaaaggt ccggtagtag acggtgcaca gacttatgat
     9781 tacacgttgc cgatggctat ttttgctctc tttggtgtgc ttgctctgat tgtggctttg
     9841 atgttgaagg cagagaacaa gaagaaggga tacggtttgg aagaggcgaa tatccaaaag
     9901 taactaggaa attcaatacc taaagtaaca aaggaatttt gtatcaaggt gtaaacagaa
     9961 gagtatcagt atgaatactc tgaaataaaa aataagaagt atggctgcca aagagaaaat
    10021 caacctgtta gaggtcattc cctgtcgcag tgaacatatt acagcagaaa gggaagggga
    10081 gacaattgtg ctctcctttc cccgttttaa atatccgtgg atgcaacgct tccttgtgcc
    10141 aaaaggaatg tcgaaagaac ttcatgtgaa attggaagaa cacggtacag ctgtatggga
    10201 actgatagat ggaaaacgca atgttcgtga gattatagaa aaactcgcag accactttca
    10261 aaatgaagag ggctacgagt tgcgtgtatc ggcttatctt tctcaaatgc agaaagatgg
    10321 atttataaaa ctggtgatac cagtcgtata aataggaact tattattatt tatttgataa
    10381 atacagccca aagtatgacg gcaattgcta tcaggactcc catgataata agcgttcccc
    10441 aaacaaaata attgctgtct ttctctttct ttttctccga gtcgtggatg atacgttcca
    10501 tttcttcggg ggtggtgttg ggtagtggat aaggttcgtt tgcacggttt agatgcttca
    10561 acttatcgtt agcacgttca cgacgtaggc gggaagcttc ccgtccctct tttattcggc
    10621 gtatcatgtc gaatgcatgt ccttcaccaa ccatattctt tgttttttag aagttcactt
    10681 ccttcgtttt tctatttccc ttcttctctg tccactttga gcaatcctcc cgtattcgga
    10741 tcaaaataaa ctttgatggt agaattcttg ttgaacaaaa ccggagccag atattctatc
    10801 acaccaaatt gggtaatagg aagctcacct tcgtaaagtt tctttttacc gtcggtcagt
    10861 gtaaccatag cttgtccggg tacgttgtag gcgattccat ccaaatcttt cttcttctta
    10921 ccatcttcct gtggcatctt gaccgatttc aggtctttca gactgatata aaacggagtt
    10981 cctgccaaat cattgttggc aactacacct aacttcttcg agaagcggaa agcaacttca
    11041 ttgttgaatt ccttgtcagg ggtaaggcgg acagtgaatg ttctctcttc tttgttgcag
    11101 gtgccggaga acatttgcgt catggcttct tcctgtgcat tcagattgtc gagcataatc
    11161 ttaagctgtg ctccgtctga aggcatattg tcagcctgtc cgcgcaataa ggcatttttg
    11221 ctttcgcgga tgttatagat ttctttagcc accagctcgg ccatcttggc ggtagagcta
    11281 gccatcagaa tctcttcggt caggaattcg cgaggattcg ctttcttttg gaggactgcg
    11341 ggggcgggag cagctttttt gcctacactg ctattgctgt aaggaacatt gatcgttttc
    11401 acaatgccat cctctgtcag ttccataagc ggtgctactg tcttatcctt caattttacg
    11461 aaatacgtag tttcgctgtt gggcacacct acggatttca cttttacgct agccagttcc
    11521 cagtactctt caggatcggc ggagacgttg gtcagtcgca ggtaacgatc agcatatttg
    11581 ctgaattctc ccggagtata gttgactttg ttggctttta tttcaagttc tatttgggtt
    11641 ttgggaagac tgtaaaccac tccatagtct tttcctcggg taacccctgt cagtacttcg
    11701 gtttgtgcat aggcggacgt tgtcattagt agtcctgctg ctataatcaa ctttttcata
    11761 ttcggttctt ttttaactgg ttttgaaaac aaagttaatg aagttattga aaaaagggta
    11821 agttcttaac ttttattcgc ttacaagttg ccatgctgtc ggcagacagg tgataatatc
    11881 gcttgcgatc attccgatca ttccttgctt cttttgagcg acatcgcccg ccaatccgtg
    11941 aatgtaagtg ccgattttag cggcttcttc ggttgagtaa ccttgggcaa gcagtgccag
    12001 gattactccg gtcagtacgt caccgctacc tccggttgcc attcccggat ttccggctgg
    12061 gttgaagaaa catttacctt ctggggtgat aatggcggag taggctcctt ttaaaataat
    12121 gtgaacatgg gcggcacgag ccaattcgca agccttcatc agacgttcgt aagagtcctg
    12181 gcatttgccg gtcagacgtt ccagctcttt cggatgcggg gtgaggatgg aacccttcgg
    12241 caggtgggta agtgcatgac ggtggttggc gaggatatta agtgcgtcgg catccaccac
    12301 aacaggagtc tggcaatgtt ccagttgctc caataaagca gcttccgttt cctcgtttcg
    12361 tcccagccct gggccgatgc cgactgcttg atagtcgtcc gtgtcggtag gtacggcaaa
    12421 acaggtttcg ttgatgtcgg tttctacgat tgcttcgggt atggaggtct gcaagatgtc
    12481 gttgttgcac attggcgcat gaacagtcag caaccctact cccgaacgga ggcaggcacg
    12541 ggcagcgaga acagaggctc ctgccattcc ttttgaaccg gcaatcaata gtgcatggcc
    12601 gaagttcccc ttgtgggcaa actgtttgcg tggcttgatg agtgaacgga tttgctctat
    12661 ttccaacatt tcgtagttcg tttccatctc ttcaataccg tcttcgctta attggatgtc
    12721 cagcacttcc cattctccga caaattccgt gttctctgcg aaaagaaagg cgagcttcgg
    12781 cagttgcaga ctgaaagtta cgtcggcacg gataatatta gcttttacgt tgaatgtgtt
    12841 ttcttctccc atcagtccgg aaggaatgtc gatggctact accatagcag gggaggaatt
    12901 gatgtatttc actacggcag cgaatccgcc gcttaacggt ttgttcaggc ctgaaccgaa
    12961 taatccgtcg attaccagat ggtcgggcgt caggacggga ggtacgaatt gggtactgat
    13021 ttcgtggaat tttacttctt ccatcatttc taccagttct ttattggttt ggcagtcggg
    13081 tgaaagttct cctttcgtgt tgaagagaaa tacctcgatt ttatatcctt tttcagccat
    13141 catgcgggct acggcgagag cgtctccgcc attattcccc ggtccggcaa agatagtgac
    13201 cggcgtttcc gtattccatc tgtctgtgat ggcttttgtt aatacggttg ctgcacgttc
    13261 catcagatcg attgatgcaa taggttcgtt ctcaatggta taagcgtcca atttcttgat
    13321 actgctgctt ggaaatattt tcattgcgat gttcttttag ttttcggatt acaaatgtac
    13381 atgattcttc tgacttttcc cgtttgttgt gggaagaaaa ccataattgc aacttttaat
    13441 tcatcattag ttctatcttt gggtcagaga aatatctgct tttgaactat taagtgttag
    13501 aataactccg ccaaaaaata attcaatgca gcaccattat gaacttactt ttatttctcc
    13561 tgaaaaagat ttcttcattt catttctcat attctcattg tttttcgata aacgaaagct
    13621 aatcaaatag atatcttatg agaaacactt tttcgaaacg gtatttctca taagttctcc
    13681 catattttgg ctcaaaagcc accttattct catagtattt cagggtattt ctcatagtca
    13741 aaagccattt gttcttcctt ttttctttca gcctgcctta tttttatcag gaaatgaagc
    13801 tactatttag ataaaatagt ggctttttgc ttgaagatgc tcattggtct cgattgtccc
    13861 atatattgtg ggaaagtttt ccttcaatat acgggaatac tttcctacaa aatacgggaa
    13921 tactttccca agccttaggg aatcttttcc cacaatatgt ggaactaaga cactgtgtat
    13981 ggaagcaagc aaaaggaata catagtttta tttattcaat gtcagcttcc ggcacacgac
    14041 actatgagaa atgaagcaaa atccgggtta ttttgcgaag aaactatgag aaatacctgt
    14101 tttaaaatca tttctcatag tctatcttat tagtttactg ccacttgttt cttatttatg
    14161 agaatatgag aaatgaaaa
//
