LOCUS       gnlProkkaENFLOKOM_84   12668 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ENFLOKOM_84.
ACCESSION   gnlProkkaENFLOKOM_84
VERSION     gnlProkkaENFLOKOM_84
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 10:17:03
            Original ID  :: gnl|Prokka|ENFLOKOM_84
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12668
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..624)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg84_1"
                     /sec_met_domain="APE_KS2 (E-value: 1.3e-29, bitscore: 93.3,
                     seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYPLNIYITAHTLISSLGFGISENKKAIHDYRSGIRMQEAGRIS
                     DSPILAGMIDSVELEKRAKELLEKRAKELDISSYTRLEQLFILTIQEVISQSGVNLQES
                     DCALLLSTTKGNIDLLSNQEKRTNSDKPSGSVQSTIDNPSFLQELSADSPTFLWKMAER
                     IGHFFEAANQVEVISNACISGVSALVVAKRWIESGRYKRVIVAGG"
     protocluster    1..12668
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[0:4971]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..4971
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..12668
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12668
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             complement(609..1052)
                     /locus_tag="ctg84_2"
                     /transl_table=11
                     /translation="MKRKTNQQIAALTNRTTFRVRFSEIDSMQIVWHGEYVRYFEDGRE
                     AFGKQYGLDYMSIYREGYMVPIVDLTCQFKQSLSFGEEAIIETRYIACEAAKIKFEYVI
                     YRATDQSVVATGSTIQVFLNLNKELELINPPFYLEWKKKWNIL"
     CDS             complement(1049..1483)
                     /locus_tag="ctg84_3"
                     /transl_table=11
                     /translation="MNREAVIQGEGILNLIPQRPPIVMVDSFFGFEENRSYSGLTVTTD
                     NLFCEAGRLQEPGIIEHIAQSAAARIGFIYTRQGEKVPLGFIGSVDKLKIYNLPEAGMK
                     LFTEITVVQEVFDITLISAQVKTEEELIAECKMKIFIKKE"
     CDS             complement(1480..2550)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 126.4; E-value:
                     2.4e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg84_4"
                     /transl_table=11
                     /translation="MQQNKYDKEPLTAVEAQRLAQEIAFGPIVFQVSRLMLKFGIFQLL
                     ADERKGMTQEEISKACGLPSYGAQVLLEASLTIGTVLLREGRYCLAKAGWFLLNDKMVR
                     VNMDFNHDVNYQGMFHLEEAITNGRPEGLKVFGEWSTIYEGLSSLPSQVQKSWFGFDHY
                     YSDCSFDEALAIVFARHPKTLLDVGGNTGRWATKCVSYDDTVEVTIMDLPQQLEMMRQQ
                     TKELPGATRIHGHGANLLDPEVPFPTRFDAIWMSQFLDCFSEEEVTSILTRAARSMNRE
                     SRLYIMETFWNRQKFDTAAYCLTQISLYFTAMANGNSKMYHSDDMQRCIEAAGLEIEEI
                     HDHLGMGHSIVQCRLK"
     CDS             complement(2537..3472)
                     /locus_tag="ctg84_5"
                     /transl_table=11
                     /translation="MSTWKGKTRGGTFGYLFFIYLIKYLGITAAYLFLSLVVLYFIPFA
                     PKATKSTWFYARHILKYNRIRSLKMLLLNYYRLGQILIDKVAIGNGKVNQYQFKFEQYP
                     EFLQLLNSEQGVIMIGAHVGNWEIGVPFFDDYGKKINIVMYDAEHRRIKEILEKNGQDR
                     EFKIIPVNEDNLTHVFRITEAINQKEYVCFQGDRYLNKEKLLPGILLGQKAPFPAGPFL
                     LASRMKVPVVFYFAMREPGRTYRFHFIIAEPVVRTKEKKAEMALLEQYTVALEQILKRY
                     PEQWFNYYPFWEPAGKQSPDLKEKQKDATE"
     CDS             complement(3475..3726)
                     /NRPS_PKS="Domain: PP-binding (7-75). E-value: 3.8e-14.
                     Score: 44.9. Matches aSDomain:
                     nrpspksdomains_ctg84_6_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg84_6"
                     /sec_met_domain="PP-binding (E-value: 9.4e-15, bitscore:
                     44.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNEEIIEKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDM
                     VVLVEKNFGFNVTGQDFAGIKTFQDFYDLVITRMQEAK"
     aSDomain        complement(3502..3705)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg84_6_PP-binding.1"
                     /evalue="3.80E-14"
                     /label="ctg84_6_PP-binding.1"
                     /locus_tag="ctg84_6"
                     /protein_end="75"
                     /protein_start="7"
                     /score="44.9"
                     /tool="antismash"
                     /translation="EKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDMVVLVEKN
                     FGFNVTGQDFAGIKTFQDFYDLV"
     CDS             complement(3748..4971)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (65-405). E-value:
                     5.5e-53. Score: 172.2. Matches aSDomain:
                     nrpspksdomains_ctg84_7_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 293.9; E-value:
                     3.5e-89)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg84_7"
                     /sec_met_domain="APE_KS1 (E-value: 3.9e-159, bitscore:
                     519.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVVITGMGIYSCIGKNLDEVKDSLYNGKSGIGIDPVRKELGYF
                     SALTGILERPDLKKLLDRRKRLCLPEQGEYAYLATLEAFRNAGIDEAFLEANEVGILYG
                     NDSSAAPVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACA
                     SGSHAIGMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAEPEKASKPFDK
                     RRDGLIPSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQM
                     AIKDAGIALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAG
                     ASEVIYSTLMMNNGFIAPNLNFEEADEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNST
                     LIIRQIKE"
     aSDomain        complement(3757..4776)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg84_7_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="5.50E-53"
                     /label="ctg84_7_PKS_KS.1"
                     /locus_tag="ctg84_7"
                     /protein_end="405"
                     /protein_start="65"
                     /score="172.2"
                     /tool="antismash"
                     /translation="RLCLPEQGEYAYLATLEAFRNAGIDEAFLEANEVGILYGNDSSAA
                     PVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACASGSHAI
                     GMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAEPEKASKPFDKRRDGLI
                     PSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQMAIKDAG
                     IALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAGASEVIY
                     STLMMNNGFIAPNLNFEEADEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNSTLIIRQI
                     "
     CDS             complement(4998..5726)
                     /NRPS_PKS="Domain: PKS_KR (3-169). E-value: 1.3e-16. Score:
                     52.9. Matches aSDomain: nrpspksdomains_ctg84_8_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     213.3; E-value: 6.4e-65)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg84_8"
                     /sec_met_domain="adh_short (E-value: 3.9e-36, bitscore:
                     114.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYALVTGGSRGIGRAVSCKLAEMGYFILINYQSNDAEAEKTLQL
                     VQEKGSNGEIMKFDVTDPAAIALALNNWASQHPDEYIEVLINNAGIRKDNLMLWMTGEE
                     WNKVLDISLNGFFYVTQPLLKNMLVKRYGRIVNIVSLSGIQGMPGQANYSAAKGGVIAA
                     TKALAQEVAKKKVTVNAVAPGFIRTDMTEGIDENEWKKHIPAGRFGTAEEVADLVGFLA
                     SPASSYITGEVISINGGLYT"
     aSDomain        complement(5220..5717)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg84_8_PKS_KR.1"
                     /evalue="1.30E-16"
                     /label="ctg84_8_PKS_KR.1"
                     /locus_tag="ctg84_8"
                     /protein_end="169"
                     /protein_start="3"
                     /score="52.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALVTGGSRGIGRAVSCKLAEMGYFILINYQSNDAEAEKTLQLVQE
                     KGSNGEIMKFDVTDPAAIALALNNWASQHPDEYIEVLINNAGIRKDNLMLWMTGEEWNK
                     VLDISLNGFFYVTQPLLKNMLVKRYGRIVNIVSLSGIQGMPGQANYSAAKGGVIAATKA
                     LAQ"
     CDS_motif       complement(5652..5714)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg84_8_0001"
                     /evalue="2.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg84_8"
                     /protein_end="25"
                     /protein_start="4"
                     /score="13.5"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRAVSCKLAEMG"
     CDS             complement(5728..7251)
                     /locus_tag="ctg84_9"
                     /transl_table=11
                     /translation="MIADKSINLDTLYKVLFDNEKLELSKECIRKVEESFDFLQSFSSD
                     KIIYGINTGFGPMAQYRIEDQSLIELQYNIIRSHSTGAGKPLPELYVKAAMIARLYTFL
                     QGKSGVHMELVSLLCEFINRGIYPFIPEHGSVGASGDLVQLAHIALTLIGEGEVFYQGK
                     LRDAATVLEENGLQPFSMRIREGLSVTNGTSVMTGIGIVNLIYAKKLLRWSVAASVMMN
                     EIAASYDDFMAQALNEAKHHKGQQEIAAMMREWVAGSKCVLQRENELYNQVHKEKIFEH
                     KVQPYYSLRCVPQILGPIYDELKNAEEVLINEINSACDNPIVDPDTQNIYHGGNFHGDY
                     ISFEMDKLKIAVTKLTMLCERQINYLFHDRINGILPPFVNLGVLGLNYGLQASQFTATS
                     TTAECQTLSNPMYVHSIPNNNDNQDIVSMGTNSALLAKTVIENSYQVMAIQFMGMAQAI
                     DYLKIQDRLSPKSRQVYEEIRSFFPVFTNDTPKYKEIERMMDYLKKENK"
     CDS             complement(7408..7839)
                     /locus_tag="ctg84_10"
                     /transl_table=11
                     /translation="MEEIVFHHTLPIQLRFNDVDKFGHVNNTVYFSFYDLGKTEYFASV
                     CPGVDWEKIGIVVVHIEADFVKQIFASDHIAVQTAVSKIGTKSFHLIQRVIDTETNEVK
                     CICKSVMVTFDLERHESMPLTEEWIEAICKYEERDLQKA"
     CDS             8109..8717
                     /locus_tag="ctg84_11"
                     /transl_table=11
                     /translation="MCYFCVLFLTEINQEMIEDIKKACQVMNEGGVILYPTDTVWGIGC
                     DATNEEAVRRVYEIKKRADSKAMLVLVDSPVKVDFYVQDVPDVAWDLIEVADKPLTIIY
                     SGARNLAPNLLAEDGSVGIRVTNEDFSRRLCQQFRKAIVSTSANVSGQPGAANFSEISD
                     EIKSAVDYIVGFRQDDMNKPKPSSIIKLEKGGVIKIIRE"
     CDS             8718..10511
                     /locus_tag="ctg84_12"
                     /transl_table=11
                     /translation="MKGEKLSLLQRCIKWREANIKEKQFILILSFLVGIFTAFAALILK
                     FFIHQIQNFLTNNFNATEANYLYLVYPVVGIFLAGWFVRNIVKDDISHGVTKILYAISR
                     RQGRIKRHNIWSSTIASAITIGFGGSVGAEAPIVLTGSAIGSNLGSVFKMEHRTLMLLV
                     GCGAAGAIAGIFKAPIAGLVFTLEVLMIDLTMSSLLPLLISAVTAATVSYIVTGTEAMF
                     KFHLDQAFELERIPFVILLGIFCGLISLYFTRAMNSVEGVFGKLNNPYKKLAFGGVMLS
                     VLIFLFPPLYGEGYDTINLLLNGTSAEEWDTVMNNSMFYGYGNLLLVYLMLIILLKVFA
                     SSATNGGGGCGGIFAPSLYLGCIAGFVFSHFSNDFAFSAYLPEKNFALMGMAGVMSGVM
                     HAPLTGVFLIAELTGGYDLFLPLMIVSVSSYLTIIAFEPHSIYSMRLAKKGQLLTHHKD
                     KAVLTLMKMENVVEKDFVVVHPEMDLGELVKAIAASHRNVFPVTDKKTGELLGIVLLDD
                     IRNIMFRQELYHRFTVNKLMISAPAKIFDTDGMEQVMQTFDDTKAWNLPVVDEEGRYQG
                     FVSKSKIFNSYRQVLVHFSED"
     CDS             10576..11517
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1228:methionyl-tRNA formyltransferase (Score: 216.6;
                     E-value: 6.4e-66)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg84_13"
                     /transl_table=11
                     /translation="MGTPDFAVEALRQLVEGGYNVVGVITMPDKPAGRGHKIQYSPVKQ
                     YALEQNLPLLQPEKLKDEAFVEALREWKADLQIVVAFRMLPEVVWNMPRLGTFNLHASL
                     LPQYRGAAPINWAVINGDTETGITTFFLKHEIDTGEVIQQVRVPIADTDNVEVVHDKLM
                     MLGGKLVLETVDAILNGTVKPISQEEMAVVGELRPAPKIFKETCRIDWNQPVKKIYDFI
                     RGLSPYPAAWSELIASEKAESVVVKIFESEKVYESHQLAAGTIVTDGKKFMKVAVPDGF
                     VSILSLQLPGKKRLKTDELLRGYRLEDGCKMK"
     CDS             11585..12235
                     /locus_tag="ctg84_14"
                     /transl_table=11
                     /translation="MKPIIAPSILSADFGYLAKDIEMVNRSEAEWVHIDIMDGVFVPNI
                     SFGFPVLKYVAKLSKKPLDVHLMIVNPEKFIPEVKALGAHTMNVHYEACPHLHRVIQQI
                     REAGMQPAVTINPATPVALLQDIIRDVYMVLIMSVNPGFGGQKFIEHSVEKVRELRALI
                     ERTGSKALIEVDGGVNLETGARLVEAGADALVAGNAVFGAQDPVEMIRQLHEL"
ORIGIN
        1 cccgccagcg acaatcaccc gtttgtaacg ccctgattct atccatctct tggcaacgac
       61 cagtgccgag actccagata tacaggcgtt ggagataact tctacctgat tggctgcctc
      121 aaaaaaatgc ccgattcgtt ctgccatttt ccaaagaaaa gtcggactat cggctgataa
      181 ttcctgtaaa aaggaaggat tatcaattgt tgattgtaca gaaccgcttg gcttgtccga
      241 attagttctt ttttcttgat tgctcaataa atcaatattt cccttcgtag tagagagcaa
      301 caaagcacag tccgactctt gcagattcac tcccgattgg gaaatcactt cctgaatagt
      361 caatataaac agttgctcta accgggtata agaggaaata tccagctcct ttgcccgctt
      421 ttctaatagt tctttagctc tcttttccaa ctcgacagaa tcaatcatcc ctgccagaat
      481 cggactgtca gaaatccgtc cggcttcctg catacgaatc ccgcttcgat agtcatggat
      541 tgcttttttg ttttccgaaa taccgaaacc taacgaacta atcagcgtat gggctgtgat
      601 gtatatattt aaaggatatt ccatttcttt ttccattcca gataaaacgg aggattgata
      661 agctccagtt ctttattcag gttcaggaac acttgtatgg tgcttccggt ggccactaca
      721 ctctggtcgg tagcccggta gataacgtat tcgaatttta tcttggctgc ctcacaggca
      781 atatagcgtg tttcgataat cgcttcttca ccaaaggaca atgattgctt gaactggcag
      841 gttaaatcta cgatgggaac catgtagcct tcccggtaaa tgctcatata atccaaacca
      901 tactgtttgc cgaaagcttc ccgcccatct tcaaagtagc gcacgtactc gccatgccat
      961 acaatctgca tggagtcaat ttcgctgaac cgtactctga aagtagtccg gttagtcaag
     1021 gctgcaatct gttgatttgt tttccgtttc attctttttt gataaatatt ttcatcttac
     1081 attcagcaat cagctcttct tccgttttca cttgtgccga aataagcgta atatcgaata
     1141 cctcttgtac gacggtaatc tctgtaaata atttcattcc ggcttccggc aagttgtaga
     1201 ttttaagttt gtctaccgaa ccgataaaac ctaacggaac tttttcaccc tgccgggtat
     1261 aaataaaccc gatacgtgca gccgctgatt gtgcgatatg ctcaataatt cccggctctt
     1321 gcagtctgcc tgcctcacaa aataaattgt cggtagtgac agtcaatccg gaatatgaac
     1381 ggttttcttc aaatccgaag aaactgtcca ccataacgat tggcggacgc tgtggaatca
     1441 ggttgagtat tccttctcct tgtatgacgg cttctctgtt catttcaatc tgcattgtac
     1501 gatgctgtgt cccattccta aatggtcatg tatctcttcg atttccaatc ctgctgcttc
     1561 gatgcatcgt tgcatatcgt ccgaatgata catcttgctg tttccgtttg ccatcgctgt
     1621 aaaatagaga ctgatttgtg tcaggcaata agcggctgtg tcaaatttct gtcggttcca
     1681 gaaagtctcc ataatataca ggcggctctc tcggttcata gaacgggctg cacgggtcaa
     1741 tatgctggta acttcttctt ccgagaaaca atcgaggaac tggctcatcc aaatagcatc
     1801 gaaccttgtc gggaaaggca cctccggatc aagcagattg gcaccatgac cgtggatacg
     1861 tgtagctccg ggcagctctt tggtttgttg acgcatcatc tccaattgtt gcggaagatc
     1921 catgatggtt acttccactg tgtcgtcgta gcttacgcat ttggtcgccc agcggccggt
     1981 attgcctccc acatccaata aagtcttggg atggcgggcg aagacaattg ccagtgcttc
     2041 atcgaacgaa caatccgagt aataatgatc gaaaccgaac cagctctttt gtacttgtga
     2101 aggcagactt gacaaccctt catagatagt actccattca ccgaatactt tcagtccttc
     2161 aggacgtccg ttggtgatgg cttcttccag atgaaacatt ccctgatagt tgacatcatg
     2221 gttgaagtcc atattgacac gtaccatttt gtcattgagc agaaaccagc cggctttcgc
     2281 aaggcagtat cgcccttcac gcaacaatac ggtgccgata gtcaatgatg cctccaacaa
     2341 tacttgtgcg ccataagagg gcagcccaca agctttgctg atttcttctt gcgtcatacc
     2401 tttgcgctcg tcggccaata actggaaaat accgaattta agcataaggc gtgatacctg
     2461 aaaaacaata ggcccaaaag ctatttcttg tgccaggcgt tgtgcctcta ccgctgtcaa
     2521 cggctctttg tcatatttat tctgttgcat ctttttgttt ctcttttaaa tccggtgact
     2581 gctttccggc aggttcccag aatggataat aattgaacca ttgttccgga tagcgtttta
     2641 gtatctgttc caaagcaaca gtatattgtt cgagcagagc catctccgct ttcttttctt
     2701 ttgttcgtac taccggttcc gctattataa aatgaaaacg gtaagttctt cccggttccc
     2761 tcattgcaaa gtagaatacc accggaactt tcattcgcga agcgagcagg aaaggaccgg
     2821 caggaaaagg agctttctgt cccagtaaaa ttcctggcag aagtttctct ttgttcagat
     2881 aacggtcgcc ttggaaacat acatattctt tttggttgat cgcctcggtt atgcggaaaa
     2941 cgtgtgtcag gttgtcttca ttgacaggga taatcttaaa ttccctgtcc tgaccgtttt
     3001 tctccaggat ctctttgatt ctacgatgtt cggcatcgta catcacgata ttgattttct
     3061 ttccgtaatc atcaaagaaa ggaacgccta tttcccagtt tcccacatgg gcgccaatca
     3121 taatcactcc ctgttcactg ttcagcagtt gcagaaactc cggatactgc tcgaatttga
     3181 actgatattg atttactttt ccattaccga tggctacctt gtcaatcagg atttgtccta
     3241 atcggtaata gttgagtagt aacattttca aagaacgtat cctattgtat ttcagaatgt
     3301 gacgggcata aaaccaggtg cttttggttg ctttcggagc aaacggtatg aagtagagca
     3361 ctaccaggct tagaaaaaga taagcggcag taatgcccag atacttaatc aggtaaataa
     3421 agaataagta tccgaacgtt cctccccggg ttttgccttt ccacgtcgac atatttactt
     3481 ggcttcctgc atacgggtga taacgagatc gtagaagtcc tggaaggttt tgatacctgc
     3541 aaagtcttgt ccggttacgt tgaaaccgaa attcttttct accagtacca ccatgtcgac
     3601 caagtccaga ctgtccagtt caagagtttc cattaacggc gcatccggct ggatgacgtc
     3661 gatgtctact tcaaactctt ctgccagagt tgttcttatt ttctcgatga tttcttcgtt
     3721 tgtcatatat ctgttttctt tagtaattta ttctttgatt tggcgtataa tcagggtgga
     3781 attggttcct ccgaatccaa acgagttgga aaggaacgta tcaaattcca gatttacccg
     3841 ttgggtaggt atattcaact gtgcggaagc ctcgtccgct tcctcgaaat tgaggttggg
     3901 agcgatgaaa ccgttgttca tcatgagggt ggagtaaatc acttcactgg cacctgccat
     3961 ccacatttca tgtccggtca tggacttcgt ggaagtgaca tacgggtgat gtccttcaaa
     4021 tacttccgca atggctttcg cttcgtttag gtcgcctacc ggagtggaag tggcgtgtgc
     4081 gttgatataa ctgatttgtt cgagtgcaat acccgcatct ttgatggcca tctgaagaga
     4141 acgtttcgga ccgtccacgt tcggtacgga gatatgatct ccattggaag agaaaccgta
     4201 accgataact tcggccaaaa tgggagctcc cctttttact gccgattcat agctctctaa
     4261 taccagactg gcggctcctc cactcggaat cagtccgtca cgtcgtttat caaaaggttt
     4321 ggaggctttc tcgggctctg cttcctgggt ggaaaatgcg cttagcccgt cgaaactgcc
     4381 gaccgcataa ggatttactt cttgtgcgcc accgcaaaga atacaatcct gcaatcctga
     4441 tttaatgagc agatacccca tgccaatagc atgagaacca cttgcacaag ctccggcaat
     4501 ggtgaagtta actcctctaa gcttgaagat aaccgacagg ttcattgtca cggtagaatt
     4561 catcgactgg aaaatagaac cggaacctac caacgctgtg tttttctttt cacgaatgat
     4621 gtccactgcg ttgatgacag gggcagcact actatcattg ccatacaaga tacccacttc
     4681 attagcttca agaaaagcct cgtcaatacc ggcgttacgg aaagcctcca aagtggcgag
     4741 ataagcatat tctccctgtt ccggcaggca gagacgttta cgacgatcta atagtttctt
     4801 caagtcggga cgttccaata tgcccgttaa tgcagaaaaa tagcccagtt ctttccgtac
     4861 cggatctatg ccaatccccg atttcccatt gtatagtgag tcttttactt catccaggtt
     4921 cttgccgatg caagagtaaa ttcccattcc cgtgataaca actcttttca ttattttgtc
     4981 tattctatgc ttttgtttta agtatatagt cctccgttga tggaaatcac ctctcctgtg
     5041 atataggatg aggccggaga tgccagaaaa ccgacgagat cggcaacctc ttccgcagta
     5101 ccgaaacgtc ctgcaggaat gtgttttttc cattcgttct catcaatccc ttccgtcata
     5161 tccgtgcgga taaatcctgg ggctacagcg ttgactgtta cctttttctt ggcgacttct
     5221 tgtgccagtg ctttggtagc ggctattacg ccacctttgg ctgcggaata gttagcttgt
     5281 ccgggcattc cctgaatacc tgacaaggat acgatattga caatacgtcc ataacgtttg
     5341 accagcatat tcttcaataa aggctgtgtc acataaaaga atccgttcaa actgatatcg
     5401 agcactttgt tccattcttc tcctgtcatc caaagcatca ggttgtcttt gcggatgccc
     5461 gcattgttaa tcagtacttc gatgtattcg tcaggatgtt gtgacgccca gttgttcaag
     5521 gcaagggcaa tagcggcagg gtctgtcaca tcgaacttca tgatttctcc gttacttcct
     5581 ttttcctgca ctaactgcaa cgttttttcc gcttctgcgt cgttactctg ataattaatc
     5641 agtataaagt agcccatttc cgccagtttg caactgacag cacggccgat acctcgactt
     5701 cctccggtta ctaatgcgta tttcatttta tttattttct tttttgagat agtccatcat
     5761 tctttctatc tctttgtatt taggtgtgtc attggtaaat acagggaaga agctacgtat
     5821 ctcttcatac acctgacggc ttttggggct tagacgatcc tgtattttca ggtagtcgat
     5881 ggcttgtgcc attcccataa attgaatagc catcacctga taagaattct ctatgactgt
     5941 ttttgctaat agagccgagt tggttcccat gctgacaata tcctgattat cgttgttgtt
     6001 aggaatactg tgcacataca tcggattcga caatgtctga cattcggcgg tagtggacgt
     6061 tgctgtgaat tgcgaagcct gcaaaccgta gttcaatcca agcactccca agtttacaaa
     6121 aggaggcagg atgccattga tacggtcgtg gaacagataa ttgatctgtc tttcgcaaag
     6181 catggtcagt ttggttacgg cgattttcag tttatccatt tcgaaagaga tgtaatctcc
     6241 gtggaagtta ccgccatgat aaatattttg tgtgtccgga tcgacaatcg gattgtcgca
     6301 ggcggaattt atttcgttaa tcaatacttc ttccgcattc ttcagctcat catagatggg
     6361 accgaggatt tgcggaacac atcgcaagga ataatagggc tgtactttgt gctcgaagat
     6421 tttttctttg tgcacctggt tgtatagctc attctctctt tgaagtacgc atttgctgcc
     6481 cgcgacccat tctctcatca tagcggctat ctcttgttgc cctttgtgat gcttggcctc
     6541 gtttaatgcc tgtgccatga aatcatcata agaggcggca atctcattca tcatgacaga
     6601 agcggctacc gaccaacgga gcagcttttt ggcataaatc agattgacga taccgattcc
     6661 tgtcatcaca gaagtaccgt ttgtgacgga taatccttcg cggatgcgca ttgaaaaagg
     6721 ttgcagaccg ttttcctcaa gcacagtagc ggcatcacgc aatttcccct gataaaaaac
     6781 ttccccttct cctattaatg tcagggcaat atgggccagt tgcacgagat cgccgctggc
     6841 acctacactt ccatgttcgg gtatgaacgg ataaattcca cggttgataa attcacagag
     6901 aagagatacc agctccatgt gtactcctga tttcccctgt agaaaagtgt acaggcgggc
     6961 aatcatagct gcttttacat aaagttcggg aagtggtttg ccggcaccgg tggaatggct
     7021 tcgaatgata ttgtactgaa gctcgatcag tgactgatct tctatccggt attgtgccat
     7081 tgggccgaac cccgtattga taccataaat aatcttatcg ctggaaaaag attgtaggaa
     7141 atcgaagctt tcctctactt ttcggatgca ttctttagag agttccagct tctcattatc
     7201 aaacaatact ttataaaggg tatctaaatt tatacttttg tcagctatca ttttctgtac
     7261 tagatatttt atgccttatt aattaaggta caaaaatagg caatttctgt tatatagcgg
     7321 acatgaatta gaataaaact ttttccggag aattggtttt gcttgttttg tttctcattc
     7381 gtgagggggc tttttcaaaa aatctatcta tgctttttgc aagtcccgtt cttcatattt
     7441 gcagatcgcc tctatccatt cttctgtcag tggcatggat tcatgtcttt caagatcgaa
     7501 agtaaccata acagacttgc agatacattt tacttcattc gtttctgtgt cgataacccg
     7561 ctggatcagg tgaaagcttt tggtgcctat cttagaaaca gcagtctgta cggcgatatg
     7621 atcggatgcg aatatctgtt tgacgaaatc cgcttcgata tggacaacga caatcccgat
     7681 cttttcccaa tctactccgg ggcatactga agcgaagtat tcagtctttc ctaagtcgta
     7741 aaaggagaag taaactgtgt tgttgacgtg accaaatttg tctacatcat tgaatcgcaa
     7801 ttggataggt aatgtgtgat gaaatacgat ttcttccatt gttttctctt aaacgtttta
     7861 aattcgacac aaaaatggca cttttgcttt cttgcttgaa attgaggcaa agatagagat
     7921 ttctaatgat tctgctttcg gagataagga agattttcgt taataatcgt ttaaaacgaa
     7981 gttttgggat gtttgtcctg ttagggaaac acgcttgtaa taatgtaata gttaaattat
     8041 tgtctgccaa cagttgattt taaagggtaa tttaaaaacg tcaggataga tttcactaaa
     8101 tggaataaat gtgttatttt tgcgtcttgt tcttaacgga aattaatcaa gaaatgatag
     8161 aagatattaa aaaagcctgt caggtgatga atgaaggagg agtgatcctt tatcccactg
     8221 ataccgtatg gggtataggc tgtgacgcga ctaatgaaga ggctgtacgc cgggtatatg
     8281 agatcaagaa acgtgctgat agcaaagcta tgttggtgtt ggtggattct ccggttaaag
     8341 tggattttta tgtacaggat gtacctgatg tagcatggga tttgattgaa gttgccgaca
     8401 agccgttgac gattatttat tccggagcac gaaatttagc acctaatctg ctggccgaag
     8461 atggcagtgt agggattcgt gtgacgaatg aagatttttc cagaagactc tgtcagcagt
     8521 tccgtaaagc aattgtttct acttcggcta atgtcagcgg gcagccgggt gctgctaatt
     8581 ttagtgaaat cagtgatgaa atcaaatcgg cggtagatta tatagttggc tttcgtcagg
     8641 atgatatgaa taagccgaaa ccctcaagta ttattaagtt ggaaaaaggt ggagtgataa
     8701 agataattcg cgaataaatg aaaggagaaa aacttagttt attgcagcgt tgtatcaaat
     8761 ggcgggaagc gaacataaag gagaagcaat ttatcctgat attaagtttt ctggtcggaa
     8821 tcttcactgc gtttgctgcg ttaatattga aattttttat ccatcagata cagaatttcc
     8881 tgactaataa tttcaatgca acagaagcta actatttgta tttggtatat ccggtagtcg
     8941 gtattttcct tgcaggttgg tttgtgcgta atattgtaaa ggatgatatc agtcatgggg
     9001 tcaccaaaat tctatatgcc atctcccgta ggcagggacg tatcaagcga cacaatatct
     9061 ggtcgtctac tatcgccagt gccataacca tcggatttgg tggatcggtc ggagcagagg
     9121 caccaattgt actgacaggt tcggcaatcg gttccaatct cgggagcgtg tttaagatgg
     9181 agcatcgcac gttgatgctg ctcgtaggtt gtggtgcggc aggtgccatt gccggtattt
     9241 ttaaagctcc gattgcggga ctggtattta ccttggaagt gctgatgatt gacttaacca
     9301 tgtcttcttt gcttcccctg ctgatttctg ccgtgacagc agcaactgtt tcgtacatag
     9361 tcactggtac ggaggctatg tttaagttcc acctcgatca ggcatttgaa ctggaacgta
     9421 ttcctttcgt tatcttgctg ggaatttttt gtgggctgat ttcgttgtac ttcacacgtg
     9481 ccatgaattc ggtagaaggt gtatttggca aactcaataa cccttacaag aaactggctt
     9541 ttggtggtgt gatgttgagt gtattgattt tccttttccc acctctttat ggtgaaggat
     9601 atgatacgat taatcttttg ttgaatggaa cgtctgccga agagtgggat acggtcatga
     9661 acaactctat gttttatggc tatggtaatt tgttgctggt ttatctgatg ctgattatct
     9721 tattgaaagt atttgcttcc agtgcaacaa acggtggagg tggttgtggt ggtatctttg
     9781 ctccttcgct ttatctggga tgtattgccg gttttgtttt ctctcatttt agcaatgact
     9841 ttgctttctc cgcttatttg ccggagaaga atttcgcatt gatgggaatg gcgggagtaa
     9901 tgagtggtgt catgcatgct ccattgacag gggtgttcct gatagccgag ctgacaggtg
     9961 gatatgattt atttcttccg ttgatgattg tatctgtaag ttcatatctg acaattattg
    10021 ctttcgagcc tcatagtatc tattcgatgc gtttggctaa gaagggacaa ttgctgacac
    10081 atcacaagga taaagctgtg ttgacgctga tgaaaatgga aaacgtggtg gagaaagatt
    10141 tcgttgtcgt acacccggaa atggacttgg gcgaactggt gaaagcaatt gcagcttccc
    10201 atagaaatgt ctttccggtg acagataaga aaacgggtga attgttggga attgtattgc
    10261 tcgacgatat tcgcaacatc atgttccgac aagaacttta tcatcgtttc actgttaata
    10321 aattgatgat atctgctcct gccaaaatct tcgatacgga tggaatggag caggttatgc
    10381 aaacatttga cgatacgaaa gcctggaatc ttccggtcgt agatgaggaa ggccgctatc
    10441 agggatttgt ctctaaatca aagatattta attcgtatcg gcaagtgctg gtacattttt
    10501 ctgaagacta atccgtgcct aagtaatgat aacatattta aaatgatgaa gaaagaggac
    10561 ttaagaatag tatatatggg gactcccgat tttgcagtag aggccctgcg tcaattggta
    10621 gaaggcggtt ataatgtagt gggtgtgatt acgatgcccg ataaacctgc cggacgcgga
    10681 cataagattc aatattctcc tgtcaaacaa tatgcgctcg aacagaattt accgttgctt
    10741 caaccggaaa agttgaaaga tgaagctttt gtggaagcgt tgcgtgaatg gaaagcggat
    10801 ttgcagattg tagttgcttt ccgtatgttg ccggaagtgg tatggaatat gccgcgactg
    10861 ggtacattta atcttcatgc ttctttactt cctcaatatc gtggagctgc tcctatcaac
    10921 tgggcggtta tcaacggtga tacggaaacc gggattacga ctttcttttt gaagcatgag
    10981 atagataccg gagaggtcat tcaacaggta cgtgtgccta ttgcagatac ggataatgta
    11041 gaagtggtac atgataaatt gatgatgttg ggaggaaagc tggttcttga aacagtagat
    11101 gctatactga atggaacggt caaaccaatt tctcaagaag aaatggcagt tgtcggtgaa
    11161 ctccgtcctg ctccgaagat atttaaagaa acttgccgga ttgactggaa ccagccggtg
    11221 aagaagatct acgattttat ccgtggacta tcaccttacc ctgctgcctg gagtgaactg
    11281 attgcttccg aaaaagcaga aagtgtggtc gtgaaaatat ttgaaagtga gaaagtttat
    11341 gaatcacatc aattggctgc cggaacaatc gtgactgatg gcaagaaatt tatgaaagta
    11401 gctgtaccgg atggatttgt atctattctt tctttacaat tacccggtaa gaaacgactg
    11461 aaaacagatg agttgcttcg tggttatcgc ctggaagatg ggtgtaagat gaagtgatct
    11521 gacaataaga tagaataaaa accgtcccga acacgagaca attagaacct aaaataaaag
    11581 aattatgaaa ccgattatcg ctccttctat tctttctgcc gattttggat atttggcaaa
    11641 ggatattgaa atggtaaacc gcagtgaagc ggagtgggta catattgata ttatggacgg
    11701 agtatttgtt ccgaatattt catttggctt tccggtactg aaatatgtag cgaagttaag
    11761 taagaagccg ttggatgtgc atttgatgat tgtgaatccg gagaaattca ttccggaagt
    11821 aaaagcattg ggtgctcata cgatgaatgt gcattatgaa gcttgtccac atctgcatcg
    11881 ggtgattcaa caaatcagag aagccgggat gcagcctgct gtaacgatca atcctgctac
    11941 tcctgtagct cttctgcaag atattatccg ggacgtgtat atggtgctta tcatgagcgt
    12001 gaatccagga tttggcgggc agaagtttat cgaacattcg gtagaaaaag ttcgtgaact
    12061 gcgtgccttg attgaacgga caggttcgaa agccctgatt gaagtagacg gtggcgtgaa
    12121 cctggaaaca ggagcccgtc tggttgaggc gggagccgat gcgctggtgg ctggaaatgc
    12181 tgtctttggt gcacaggatc cggtagaaat gattcgtcag ttgcacgaac tgtaactaat
    12241 ctattgaatt ccttttatat ccatcgatat ccatttatac gcctgcttat cccttggata
    12301 gcaggcattt tttgtggaga tcattttttt gaccgttcat gggatcccct ttgtggtatt
    12361 ctcttctttg gcttttttgc tgtattgtct tttgctcttt attttctgaa acgctattcg
    12421 ctgcgatggt gttttgggat agctatctcc gctctttgtt ttacgggagg atggcttggg
    12481 atgactggac aattgcaaca ggctgtctgc tcttttccga aagaagaaac tgtgtaccgg
    12541 gttttgataa cggatgcagc tcaaccaaaa gaacatactt acctctgtca ggcattatta
    12601 aaagaacgtc gtgatactgc gggcatatat ccgataggac atactgcggt tctttatcta
    12661 cagcaaga
//
