LOCUS       c00030_gnlPro..        16770 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FKIMNIKK_30.
ACCESSION   c00030_gnlPro..
VERSION     c00030_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 21:08:08
            Original ID  :: gnl|Prokka|FKIMNIKK_30
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16770
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16770
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1162:6770]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1163..6770
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..16770
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16770
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             1163..2881
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.7e-48, bitscore:
                     155.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIRLAESYRA
                     KGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
     CDS             2899..3408
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_2"
                     /sec_met_domain="ALS_ss_C (E-value: 1.6e-22, bitscore:
                     70.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(3477..4733)
                     /locus_tag="ctg30_3"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGNPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKDKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERHRKLDAAMDEIRMKFGNDKITRASIMNSN
                     ARIGRKAKAQMKNEKMEEP"
     CDS             5496..6209
                     /locus_tag="ctg30_4"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISDHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAIKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     APGGYRGDTRANAARILYLCQKYQLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLI
                     LNNQLPKLKVFLQTR"
     CDS             6474..6770
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_5"
                     /sec_met_domain="ALS_ss_C (E-value: 5.8e-22, bitscore:
                     69.0, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEVIKVIDFTDVFVRMKEILYIKVFNCSREDKAELFQIAETFQA
                     KVIDYGKDSLLLEFVQTATKNNAVVKLIKEEFHRIEVVHGGSVGIESISMMER"
     CDS             7145..7780
                     /locus_tag="ctg30_6"
                     /transl_table=11
                     /translation="MNTTTTTTTAAAKRSSTLYMVELAMMIAIILLMSFTPLGYLRTPG
                     LSITLLTIPVAVGAIILGPKGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFIV
                     CIVARVLEGWITGLIFAALYKSPAKKFSHYVASLACPLLNTFFFMGFLCLFFYNTDYIQ
                     GIVSSLGVSNPVVFVAAFVGVQGLIEAGFCFVVGSIVSKALSVALKRA"
     CDS             7887..8852
                     /locus_tag="ctg30_7"
                     /transl_table=11
                     /translation="MSLLKEISITELSNLRIGHTSDHDAKTGVTVLYFPNGAKAGCDIS
                     GGGPASRETPLTSPVTADNPINAIVLSGGSAYGLAAADGVMNYLESQNIGYNTGAALVP
                     LVCQSCIYDLSYGDPKIRPTAKMGEEACRQAFAGTDTRTGNIGAGTGATVGKLYGMKQS
                     MKSGLGIAAVSVKNFQMAAIVVVNALGDIFSPQNGQKIAGLKTPDRSGFLDSVHELYRF
                     MTPHDQFTGNTTIGAVITNGAFSKAELNKIASMTRCAYARCINPVATMADGDSIYAASI
                     GNVSVDINMAGTLAAEVMAQAIQNAIHTSRIPDEEFLKYV"
     CDS             complement(9265..10449)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 78.4; E-value: 1.6e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg30_8"
                     /sec_met_domain="MFS_1 (E-value: 9.3e-25, bitscore: 78.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTFQGSYGISLQKIT
                     LLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHTMAAAGLILLTVLPECLGDPFVGLL
                     IAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRIFG
                     IANWKYMALVWALIPIANGILFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCA
                     GASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQ
                     YSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALL
                     ALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMIMGIKMIGSLQKYD"
     CDS             complement(10790..11554)
                     /locus_tag="ctg30_9"
                     /transl_table=11
                     /translation="MLNQFSRTELLLGKEAMNKLENSRVAVFGIGGVGGYVCEALVRSG
                     VGTFDLIDDDKVCLTNLNRQIIATRKTVGQYKTEVMRDRILDINPKADVRIHNCFYLPE
                     NAADFDFSEYDYVVDAVDTVTAKIELIMRAKEAGTPVISSMGAGNKLDASAFRVADIYK
                     TKVCPLAKVMRRELKKRGVKKLKVVYSEEQPIRPIEDMAISCRSHCICPPGATHKCTER
                     RDIPGSVAFVPSVVGLIIAGEVIKDLTAEYRR"
     CDS             complement(11881..12567)
                     /locus_tag="ctg30_10"
                     /transl_table=11
                     /translation="MKTNEEEDSRHIFRGELALVIAVMINSLAVILMLYSGSGISAISS
                     VPYAFEKVFPVITLGTWTYIFQALLILSLMILRKKFVPAYLCSFLVGFAFSEFLDVNEA
                     WINILPKTIPLRVLYFVISYLLICIGIALSNRCGLPIIPTDLFPRELSEIIKVKYSKIK
                     VSFDVICLMITACMTGLILGHINGLGIGTVMAAFTMGKVIGLIGDEMDKHFRFVNFTQH
                     CSLHVQ"
     CDS             complement(12736..14154)
                     /locus_tag="ctg30_11"
                     /transl_table=11
                     /translation="MRKTKIICTMGPSTDKGDVMEQLVREGMDVARFNFSHGPHDEQRG
                     RIQKLRELRKKYDRPVAALLDTKGPEIRLGCFKDGKVSLEEGQIFTFTNKDIEGTNECV
                     SITYKELYKDVRPGGHILVDDGLVDLEVQDISGKDIVCKVINAGVIGDKKGVNVPGANL
                     KMPFISKKDHDDLLFGIQEGFDFVAASFTRTANDIREVRKILKENGGEEIQIIAKIENQ
                     QGVDNIDEIIEAADGIMIARGDMGVEIPPEYVPVIQQKIIQKVYTAGKPVITATQMLDS
                     MISHPRPTRAEATDVANAIFQGTSATMLSGETAAGKYPVQALQMMSRIAEHMEQNIDYN
                     TIFKKTDRNENPDITNAIAHATCLTAIDLKASAILAVTKSGSTAHMMSKHRPGCLIGAC
                     TSSERVLRQLNLSWGVYPMLIKEEYSSEILCLRAIEAAQKHKLVKVGDTIVFAGGVPLG
                     IPGRTNLIRVCTVE"
     CDS             complement(14404..14934)
                     /locus_tag="ctg30_12"
                     /transl_table=11
                     /translation="MNYNRLETSLIDVIKEEQAKLGYMKEKISLYYPLSSLNHFFGGET
                     DAAGMMEILKDFPSYIEEKFGEVAVSHRGDRFCFTVSEKASEYVHNNMKENEFIKALIE
                     LVGRHGCTIEEIKELFHSYSDKIITEPMDNEEFDVMIRFGDGSDPYYYCFKDEGCHIIY
                     HRFLPEDYADFGF"
ORIGIN
        1 ataatattta ctcaaagaat caactccttt caataatatt ctactctaat atcttgcaaa
       61 actcaacatg tgcttatatg attttataat ttatatttaa ctgttaataa ccttccaaac
      121 agctgtatta tttatttttt atatcagcaa tatagaaatc tgtcaattac attactgttc
      181 actccgttct cagtaacgta gccaaaattc attcaggaac ataaatttta cagcaattat
      241 ccaaaacccg gttgacaatt tcctctctat aaatgtataa tgtaacccaa gaaaacattt
      301 gtccacccta ttcggacaat gaatatccct atatcagcca aatgccatga cagggaggag
      361 tacacaaccc cgggaagcac agagagaaag cggtcggtgc gagctttcgt gaacgaattg
      421 tggaagtagc ccccgagcag tgaaccaaac cgcatatccc gtctgatcca caagacctga
      481 acggacatgc caagtaggct tcaacgtcag ttccacgtta caggaacaca gtatatcagt
      541 actgacaaag tgcagagcca gactctgaat acaggtggta ccgcggaaac attttcgccc
      601 tgggcaaaca agcccagggc gttttttact atatttatat atcagggtca aaaagtcgtt
      661 cgtgcttgct ttaatctgtc acatcaaacc cgccgcccca cactcggcag aatcagcgca
      721 gcgccattct gccccaccct gtattggcca acacacagct cggaaattta tttgttttcg
      781 ggtgcatttg caggagtcgt agtaactctt agtgcctgga aatctgcgtt gttcagaaaa
      841 atctcactgt ctgagccgca tctgcggcga gtttgagatt tttctgaacg gttttagcag
      901 attttcagac acttagagtt cctagtacat cgttttcgaa ataactatac cactcacttg
      961 tctgcgaatc cgattgcaca ggtctaaaag cctcagcgta gcccgctacg cctgcgtttt
     1021 tataccagca cactcgaatc cgcatcctac gcgattggta tagttattta cgaaacgatg
     1081 tactagactc cgaaaccgca cccgaaaaca aataaatttc cgagcgtccc catccacata
     1141 cccaaaggag gtttacccaa atatgaaaca aatatccggc aacaaactct tagtcaaagc
     1201 cttaaaagaa gaaggcgtag aatacctctt cggctacccc ggagcctgta ccatcgacat
     1261 cagtgacgaa ctctacaaac aggacgacgt caaaatcatc ctcccccgtc acgaacaggc
     1321 ccttgtccac gaagccgacg cctacgccag aaccaccggc aaagtcggcg tatgtctggt
     1381 aaccagcggc cccggagcaa ccaaccttgt aacaggactt gcaaccgcca actatgacag
     1441 cgtacctctt gtatgcttca ccggccaggt agcccgccac ctcatcggca acgatgcatt
     1501 tcaggaagta gacatcgtag gaatcaccag aagcatcacc aaatacggcg ttactgtccg
     1561 cagacgtgaa gacctgggac gtatcatcaa agaagccttc tacattgccc gcaccggccg
     1621 tccgggacct gtccttatcg accttccaaa ggacgtaatg gcagaacttg gtagcgctga
     1681 gtatcctaaa aatgtaaaca tccgcggata caagcccaac acagatgtcc atatcggcca
     1741 gctcaaacgt gccatcaaac ttttaaacaa ggcaaaacgt cctttattcc ttgcaggcgg
     1801 cggtgtagta atctcccgcg cccacgaaat cttccgggaa gtagtagaaa aaacaaaagt
     1861 accggttgtc acaaccgtaa tgggcaaagg ttccattcct actgaccatc cgctttatat
     1921 cggaaacctc ggcatgcatg gtgcctatgc agcaaacatg gcagtcagca actgcgatgt
     1981 gctgttctcc atcggaacca gattcaatga cagaatcacc ggaaaacttc atgaatttgc
     2041 accacatgcc cagattatcc acattgatat tgatacagca tccatttccc gaaacattca
     2101 ggtggatatc cccattgttg ctgatgcaaa agaggctatc accaaaatga acgaatacgt
     2161 ccaggaatgt tcaacggaca agtggcttaa cctgatcaaa aactggaaag aagagcatcc
     2221 gcttaaaatg cgtccaaatg atcttttaag tccgatggat atcctgaaag agatcaacga
     2281 acaatttgag aacagtatta tcgtaacaga tgtaggacag catcagatgc ttgtctccca
     2341 gtatgcggaa atcacagagg gcaaacagat gatcatgtcc ggtggtctgg gaacaatggg
     2401 ctatggtctt ccaggcggca tcggagccaa aatcggaaat cccgacagac ctgtcatcgt
     2461 tatctccggt gacggcggtg tgcagatgaa cattcaggag cttgcaactg cagttctgga
     2521 agaacttcct gttatcctgt gcatctttaa caatgaatac cttggaatgg tacgccagtg
     2581 gcagaagctt ttctacggca aacgctatgc tatgaccaat ctgcgcgcag gagcactttc
     2641 ccgccgcact gaaggcatgg aatatccaca gtacacaccg gatttcatca gacttgcaga
     2701 gagctacagg gcaaaaggaa tccgtgtcac aaagaaagag gaaattgcag cagccttcga
     2761 ggaagcaaaa aagaacacaa aggcacctac agtaattgaa ttcatcattg accctgagga
     2821 aatggtttat cctatgatca aaccaggcgg aactctagaa gatatgatta tggactgttg
     2881 atcaggagga aaattattat ggataaagga atgaaaaaaa gatggatttc tctctatgtt
     2941 gagaaccagg taggtgttct gtccaaaatc tccggacttt tctccggaaa aagctacaat
     3001 ctggacagtc ttactgtagg aaccaccgag gaccccacag tatctcgaat gacgatcgca
     3061 actgtcagtg atgatgaaac ttttgagcag atcaaaaaac agttgaaccg tatgatcgag
     3121 gttattaagg ttattgattt cacagacgta tttgtccgta tgaaagagat tctgtatatt
     3181 aaggttttta actgttccaa agaagataag gttgaactgt ttcagattgc cgaaaccttc
     3241 aaggcaaagg tcattgacta tggcaaagac agcctgctcc tggaatttgt ccagacagca
     3301 accaagaatg acgcagtagt gaaactgatc aaggaagaat ttcacagaat tgaagtggta
     3361 cgtggaggaa gtgtaggaat cgaatctatc agtatgatgg aacgataaaa ctttttctga
     3421 aatttttata aagggaggat tgtcgcattg ttcttaatgc tcagtcctcc ctttacttac
     3481 ggttcttcca tcttttcgtt tttcatctgt gctttcgctt ttcgcccaat ccgtgcattg
     3541 ctgttcataa tactggcacg ggtgatctta tcatttccaa atttcatccg gatctcatcc
     3601 atagctgcat ccagctttct gtggcgttct ttattttctg tatcttcaaa cagagacatc
     3661 tgttcataag tgccatctgt aagacctgtc agtgccacac caatcagacg tagcggctgt
     3721 cctttccaga attctttaaa aagtcttgta gcatttatat aaatttcatc tgtaagatct
     3781 gtagcatttt ccagctttgt ctggtgtgaa cggtttctga aatccaaagt acggaaagtc
     3841 acggaaatac agttgcattt cttatctttt ctgcgcattc tggttgccag aacatcacac
     3901 tgctccaaaa gtatgggaaa cacctgctct atggaagtaa tatcatcgtt aaaagtagtt
     3961 tccacgctga aaccttttgc ctcatcaggc actgctttta caggggaatc atcgatacct
     4021 ctggcatatt gccatagctg atgtcccgtt ttttccccaa gccagtactg cacattggat
     4081 gctctttctc ttgccagatc accgatggta cggattccct gattcagaag cttctgctcg
     4141 gaagcttttc ccagaaacag cagattacgg ataggaagag gccacatttt ctccgggatt
     4201 tcatccggga acagagtgtg tactctgtcc ggcttttgaa aatctgatgc catctttgcc
     4261 aaaagcttat tggtagaaat tcctacattt actgtgaatc ccagctctct gtgaatcttg
     4321 tctttcagct catgagcagc agctacaggg tcaggataga tcagagaagt acctgtcata
     4381 tccagaaata cctcatcaat ggaaaaagat tccatcacag gtgcaaagga agcacagatt
     4441 gctttaaatg cccgggaaca tttatcgtat aattcaaaat cactgggaac gatcaccaaa
     4501 ttgggacatt tccgaagagc catagctact ggctcgccgg tctggatccc gtattttttt
     4561 gcagggatag atttggcaac cacgatacct gtccgtttct ttggatttcc tcctacacag
     4621 gaaggaattt ctctgagatc cggcaacccc tggctcaccc ttctggctga ttcccaggaa
     4681 agaaatgcac tgtttacatc aatatgaaaa attaaccgtt ccgtactttt cactgttctt
     4741 cctccaatat atgaattgcg ctcttcatat ctgatgattt cattttaccc tgatctgctc
     4801 tccagggtaa gaacctcgtt tgtccaaaaa agtgtcttta tttgcatcat cttgtctgag
     4861 ctgttactgt atttatattt gtttgatttc actctgctat cagagttttg aacaacaacg
     4921 ccgcacttgc catacggcag tgcggcgtct gtatttcgct accggtcaca ttgttcccgg
     4981 taactttttt tacttaattc tgaggattca tttcctctcg atatatactt atcgattagt
     5041 cataaagatt aggagcaatt tcttcgctgt ccatatttgt ggaatcatac cagtatccag
     5101 ttcagcctcc agccattcat aagagaattc cgggaatgtc tgatgtttga aatttttcca
     5161 tgttactcct ttctcatgaa gtaactgtct acacataagc aaacagtgct atcgctgtca
     5221 ttgatcagca ataagccccc gtgttttcat atagttccat tataccttct cattttcccg
     5281 aagtcaacat aatttaacat gtatcagccg tttatttgtg ttgcttttta tttgattttt
     5341 gttgtatttc agttgttttt attttgtttc ctcattgaca tttaaatcct catctgtcat
     5401 acttgaatat aacgaatgta ccatcaaaca gcagctttgc atcttccgta aggctcttat
     5461 catatataga aaccgctctg gaaaggagac aaacaatgta tctttctgac atccacacac
     5521 attctatcgc cagcggtcac ggaaccacct gtaccatctc tgacatggca aaagcagcca
     5581 gcaaaaaagg actgaaactc cttgggattt ctgaccacgg cccgggaact ctggcttccg
     5641 gaacttcttc ttatttcaga agccttcctt tttatcccag aaaaagattc ggcatagata
     5701 ttctttacgg agttgaacta aacatcctgg acagtgcagg acatacagat ctgtcagatg
     5761 aactgctgaa caacctggat tacgctatca tcagtatgca tcggcagaac taccgttcag
     5821 gctctgtatc tcagaataca gaagcttaca tcaatgcaat aaaacatcct gctgtaaaaa
     5881 tactcggcca ctgcgacgat acacatttcc ctgtagatta tgaaacgctg gcaagagcag
     5941 ctttacggga aaatgttatt tttgaaataa acgaagcttc cctcgcaccc ggaggatatc
     6001 ggggagacac aagagccaat gcagccagaa tcctgtatct ctgtcagaaa tatcagcttc
     6061 ctgttatttt gtccagcgac agccacggaa aagaacatgt tggagatttc acctatgccg
     6121 aagaattcgt tcaccagctc atgtttccgg aaactcttat ccttaacaac cagcttccca
     6181 aattaaaagt tttccttcag acacgttaaa agaatgttcc tcaaagggac attcttttat
     6241 tttatgcatt gttttttgca ttgtgttatt ttgtttattt tctataattt cttgtcaaaa
     6301 aagacgacat tttagtacat tttaattaac aaaactcact taaccattta catatctcgt
     6361 gatagatcag tcttactgta ggaaccaccg aggatcctac agtatcccga atgactatcg
     6421 caacagtcag cgatgatgaa acctttgaac agatcaaaaa atagttaaac cgcatgatcg
     6481 aggttatcaa ggtaatcgac ttcacagatg tatttgtcag aatgaaagaa attctctaca
     6541 tcaaggtttt caactgctcc agggaagata aagcagaact gtttcagatt gcagaaacct
     6601 tccaggcaaa agtcattgac tacggcaaag acagcctgct tctggaattt gtccagacag
     6661 ccaccaagaa taatgcagtt gtcaaactga tcaaggaaga attccacaga attgaagtgg
     6721 tacatggtgg aagtgtggga attgaatcca tcagcatgat ggaacgctaa atctcataat
     6781 caatattttt tgcaggatat agaaacgtct ctatatcctg tatttatttt caaacatact
     6841 ataaaatatt gcagttttta atcaaatgtg ttattgttta cgagagcgtt attcgaaaga
     6901 aaatgcatct gttttccaca tctgacagtc tggtggataa agtcatccac ttcacagtct
     6961 ggttaaattt gtgaggcgac ctgtaaggcg tctacacacc ggaaactttt accggaagat
     7021 atttcttgtt tcatatcttt tgttctgatg tatatttttc ataacgcctg atccccatac
     7081 tctaaactgt ctgaaaagca ggggacgcat tgcgccgttt tatcagacca aaaggagaat
     7141 tcatatgaac acaacaacaa ctactacaac agctgccgca aaaagaagca gcactcttta
     7201 catggtagag ttggctatga tgattgccat tattctgctc atgtccttta ccccgctggg
     7261 ctatcttcgt actcccggct tatccatcac tcttctcacc atcccggtag ctgtaggagc
     7321 tatcatcctc ggaccgaaag gtggtgctgt atgcggactt gctttcggtg caaccagctt
     7381 ctatatggct gtcacaggaa gttcagcttt cgctgccgca ctttttaaca ttaatccatt
     7441 tggcactttt attgtatgta tcgtggcacg tgtactggaa ggatggatca caggacttat
     7501 ttttgcagca ttatataaat caccggcgaa gaaattttcc cattacgttg cttcactggc
     7561 atgcccatta ctgaatactt tcttcttcat gggcttttta tgtctcttct tctacaacac
     7621 agattacatt cagggtattg tttccagtct tggagtaagc aatcctgttg tcttcgttgc
     7681 tgcttttgtg ggcgttcagg gactgatcga agcgggcttc tgctttgtag tgggaagcat
     7741 cgtttccaag gcactttctg tggcactgaa acgtgcataa tctttaaaag aacagccttt
     7801 taattctgct gttccggaag gttcactaaa aatccctgac tacattgtca ctgtagtcag
     7861 gtttttttta tcaaaaggag atttttatgt cattactaaa agagatttct attacagagc
     7921 tttcaaattt acgcatcggt catacttctg accatgatgc aaagaccggt gtaactgttc
     7981 tttattttcc aaatggagca aaagcaggct gcgatataag cggaggcggc cctgcttcca
     8041 gagaaactcc tctcacctct cctgtcactg ccgacaatcc catcaacgcc attgtcttgt
     8101 ccggaggttc tgcctatgga ctggctgctg ctgacggtgt gatgaactat ctggaatcac
     8161 aaaatatcgg ttataacacc ggtgcagccc tggttcctct tgtatgccag tcctgtatct
     8221 atgacctctc ttacggagat cctaaaatac gtccaactgc aaaaatgggc gaagaagcct
     8281 gccgtcaggc atttgcagga acagatacca gaaccggaaa tatcggtgca ggtaccggtg
     8341 caactgtggg aaaactttac ggtatgaaac aatccatgaa gtcaggtctt ggtattgccg
     8401 ctgtatctgt gaaaaatttc cagatggctg caattgtcgt tgtcaatgca ctgggagata
     8461 tcttcagtcc acaaaatggt cagaaaattg cagggctgaa aacacctgac agaagcgggt
     8521 ttctggacag tgtccacgaa ttataccgct ttatgacacc tcatgaccag tttaccggca
     8581 ataccaccat cggagctgta atcaccaatg gggcattttc aaaggctgaa ctgaataaaa
     8641 ttgcctctat gacccgctgt gcctatgcca gatgcatcaa tcctgtagca actatggctg
     8701 acggtgattc catctatgct gccagcattg gcaatgtttc tgtggatatc aacatggctg
     8761 gaactctcgc cgcagaagtc atggctcagg ctatccagaa tgccattcat acttcccgga
     8821 tcccggatga agaatttttg aaatatgtat aacagtccgc tataaaagcg cagagaaaaa
     8881 gtatcatctc tgcgctttta ttcttcctgt ctgtcttcat ttttcatctg tactctggtt
     8941 tttctccaag ccagagctgt acatttgctt cccgttccct tgccagatca ccaatagtac
     9001 ggattccctg attcagaagc ttctgctcgg aggcttttcc cagaaataac aggttacgga
     9061 caggaagtgg ccacattttc tccggtattt cgtccgggaa cagcgtgtgt actctgtccg
     9121 tttctttgga tttcctccca cacaggaggg aatctccctg agatccggca gcctctggct
     9181 tactcttctg gctgactccc aggaaagaaa tgcgctgttt acatcaatat gaaaaattaa
     9241 tcgttccata ctttttaata tatctcaatc atatttttgc agacttccaa tcatcttaat
     9301 ccccattatc atcaacacag ggaaaatcag tgccgcaaag attccaagtt tcagattatc
     9361 attcagtgct cctgaaatca tccccacata ggttggtccg gatgagcatc ccacatctcc
     9421 agcaagggca aggagggcaa acagggctgt tccgccacgc tttactgagg cagccgccat
     9481 gctgaaggtt cccggccaca taatacctac agacagaccg caaaccgcac atccaaggat
     9541 tcccaacgca ggtaccggga taaatgcgat catcagatag gaaaccatgc acagaactgc
     9601 actgtattgc ataaagcgtt ccagattgat tttatctcca aatttcccat aaaatgccct
     9661 tgagcttccc ataagaattg caaacgccat gggacctgcc agatctccga tagttttatt
     9721 gattccaaag cttttctcag ccagagtaga agcccactgg cttaccgcct gctcactggc
     9781 tcctgcacag agcatcatta acatcagaac ccagaagatt tttttcttaa aaagctctcc
     9841 catagtcagc cccttttcac cctcatccag cagtggagca atgggaactc tggtaaaaag
     9901 gattccattt gcaatgggaa tcaatgccca caccagcgcc atatatttcc agtttgcaat
     9961 cccgaaaata cgaaagaata atgtagaaag aagtaccact cccacatgtc cccaacagta
    10021 aaaggaatga aggagactca ttgctttttc cttattatct gtagggcagg cttccaccac
    10081 aggacttacc agcacctcca gcaatccgcc tccgatggca tagatcataa ctgcaatgag
    10141 aagtcccaca aacggatctc ccaggcactc cggcaatact gtgagcaaaa tcagacctgc
    10201 agccgccatt gtatgtgcca ggatcataga tgcacgataa cctattctgt ccacaaatcc
    10261 aatcgatgcc agatctacca gcaactggat tccgaaatta aaagtaacca gaagtgtgat
    10321 cttctgcagc gaaatcccgt aactgccctg aaatgtcaga aacagcagag gaacaaaatt
    10381 gtttacaata gcctgcacca catatccgat aaaacaggcc tgcactgttc tgttgtaatt
    10441 tgttttcatt caatatgata tcctccaatc tgaaatttat tagttactga gaacggagta
    10501 agcagtaaca atttattacg ctgatatcgt tcaggcattc tcattcacca aattctgcac
    10561 cttcacagtt ctatcaatca ataatgacag tgtatcacag attctttctt ttttctttca
    10621 ttatattttg aaaatcctat aaatttttat gttattttga ctttttctca tataacaatt
    10681 ctatacactc taacaggtaa tccatcaatc caattcaaaa tatttcccgc aaaaaaagat
    10741 gtgtaccata ccatttctga caccatacac atctcaaaat aaacacttct tatcttctgt
    10801 actccgcagt caggtcttta ataacctctc ctgcaataat cagcccgacg acagacggca
    10861 caaaggccac actccccgga atatctctgc gctccgtaca cttatgcgta gcacctggag
    10921 gacaaataca atgcgacctg cagctgatcg ccatatcttc aattggtctg atcggctgtt
    10981 cctctgaata aacaaccttc agtttcttca caccacgctt cttcagctct ctacgcataa
    11041 ccttcgccag cggacacacc ttcgtcttat agatatccgc cacccgaaac gcactggcat
    11101 ccagcttatt tccggcaccc atactgctga taacaggagt ccctgcctcc tttgcacgca
    11161 tgatcagttc aatcttcgca gtcactgtgt ccacagcatc taccacataa tcatactcac
    11221 taaaatcgaa atcagcagca ttctccggaa gataaaaaca gttatggatt ctcacatctg
    11281 ctttcggatt aatgtccagg atcctgtccc gcatcacctc tgttttatat tgaccaacag
    11341 ttttcctggt ggcaataatc tgtctgttaa gattcgtcag gcatactttg tcatcatcga
    11401 tcagatcaaa ggtccccaca ccgcttctga ccaatgcttc acatacatat cctccaaccc
    11461 ctccgattcc aaacactgcc acgcgggagt tctccagttt attcattgct tcttttccca
    11521 gaagaagctc tgttcttgaa aattgattca acataatatc tccatttcat tcggtattga
    11581 ccgactatct gcctgccttt cttctacttc attatttctg gtctgttctg ctttgctgcc
    11641 tgtaatgtaa gcagctctgc atgccagaaa caaaaaaaca aggagcagaa accaaagcca
    11701 gagctttctt ttgtttttta tgagcaaccg tttcataatc tgcatcacta ttccttaata
    11761 tattattttc agataccaga gttgcaacat acttccatca cagatttctt atgatatctt
    11821 tacttctata atgcgtcaag tatatcatag aaagaaaaat cctgcaatga agaaactctg
    11881 ttactgtaca tgaagtgaac agtgctgagt gaaattcaca aaccggaagt gcttatccat
    11941 ctcatcacca atcaatccaa ttacttttcc catggtaaat gccgccatca ctgttccgat
    12001 tcccagtccg ttgatatgcc ccaggatcag ccctgtcata caggcagtaa tcatcagaca
    12061 gatcacatca aaagaaacct tgatcttaga atatttcacc tttataatct ctgacagttc
    12121 acgaggaaac agatctgtag gaataatcgg cagaccgcat ctgttagaaa gtgcgatccc
    12181 tatacagatc agcagataac tgatcacaaa atataacact ctgagtggaa ttgtctttgg
    12241 caggatattg atccatgcct cattaacatc caaaaactca ctgaatgcaa atccaaccag
    12301 aaaactgcac agataagcag gtacaaattt ttttctcagt atcatcagac ttaagatcag
    12361 aagtgcctga aaaatataag tccatgttcc cagtgtaatt accggaaata ctttttcaaa
    12421 tgcataagga acactggata tggcagatat tcctgaacca gaatacagca tcagaataac
    12481 agcaagactg ttgatcatga ctgctatcac caatgccagc tctcctctga aaatatgtct
    12541 cgaatcttct tcctcatttg ttttcataac aattctctcc tctaacacaa gcaagggact
    12601 gctgtcagaa aatattttct gtcatacttt tctgacggca gacccctgtg tcttttacat
    12661 cttatatttt ctgaaaatac gattttttat cgaatcaggc aagtttccca cttcaactac
    12721 tgatattttc ctgacttact caaccgtgca gacgcggatc aggtttgttc ttcccggaat
    12781 tccaagcggt acaccaccgg caaatacaat agtgtcgcca acttttacaa gtttatgctt
    12841 ctgtgctgct tcgattgctc tcaggcaaag gatctcagaa ctgtattctt ctttgatcag
    12901 catcgggtaa acaccccagg acagattcag ctggcgaagg actctctcag agcttgtaca
    12961 tgcaccgatc agacatcctg gtctgtgttt ggacatcata tgagctgtac ttccagattt
    13021 tgtcactgca aggattgcac tggccttcag atcgattgcg gtcagacagg ttgcatgtgc
    13081 gattgcattt gtaatatccg gattctcatt tctgtctgtt ttcttaaaga ttgtattgta
    13141 atcaatattc tgctccatat gttctgcaat acggctcatc atctgaagtg cctgtaccgg
    13201 atatttaccg gctgcggttt ctcctgaaag catagttgca cttgttccct gaaaaatcgc
    13261 attggcaacg tctgtagcct ctgcacgggt tggtctcgga tgagagatca tggagtcaag
    13321 catctgtgtt gctgtaataa ccggttttcc tgctgtgtaa actttctgga tgattttctg
    13381 ctggataaca ggtacatatt ccggcgggat ctcaacaccc atgtcacctc tggcgatcat
    13441 gatgccatct gctgcttcaa taatctcgtc gatattgtca acgccctgct ggttctcaat
    13501 ctttgcaatg atctgaatct cttcaccgcc gttttctttc aggatttttc ttacttcgcg
    13561 gatatcgttt gcagtacgtg taaaagatgc tgcaacgaaa tcaaatcctt cctggatacc
    13621 gaagagaaga tcatcatggt cttttttact gatgaatggc atcttcaggt ttgcacccgg
    13681 aacattgaca cccttcttgt cgccaatcac acctgcatta ataaccttgc agacaatgtc
    13741 ctttcctgag atgtcctgaa cctccaggtc tacaagtcca tcatcaacca gaatatgtcc
    13801 acccggccgc acatccttat aaagctcttt ataagtaatg cttacgcact cattagttcc
    13861 ttcaatatct ttatttgtaa atgtaaaaat ctgtccttct tccagagaaa ccttaccatc
    13921 cttgaagcat ccaagtctga tctccggtcc ctttgtatca agaagtgctg caacaggtct
    13981 gtcatatttc ttgcgaagtt ctctcagttt ctggatacgg cctctctgct catcatgagg
    14041 tccatgtgag aagttgaaac gtgctacgtc cattccctct ctcacaagct gctccataac
    14101 atcgccctta tcagtagacg gtcccattgt acagataatt ttggtttttc tcatttaatc
    14161 tttccctcca acagtcaatt caagtttatc tatattcctg taaaataatg taataaaatg
    14221 ttacctgttt ctataaatga aaacattaag tcaaataaaa attaccatta ttgagactat
    14281 ctgtcaatat agaatttcga cttatttttg ttgatatttg acaaaaaaat aacatacttt
    14341 tattgcaaat gtcacatata tttttgccga tctggcagtt gaaaaatttt tcacccattc
    14401 ttatcaaaaa ccaaaatctg catagtcttc cggcaaaaat ctgtggtaaa tgatatggca
    14461 tccttcatct ttaaaacaat aataataagg atctgatccg tcaccaaagc ggatcatcac
    14521 atcaaactcc tcgttatcca ttggttcagt aatgatttta tctgaataag aatggaacag
    14581 ttctttaatt tcctctatcg tacatccatg tctgccgacc agttcgatca atgccttgat
    14641 gaattcattc tctttcatat tattatgtac atattcggaa gctttttccg aaacagtgaa
    14701 gcagaaacga tctcctctgt gtgatactgc tacttcacca aatttctctt ctatataaga
    14761 aggaaaatct tttaaaatct ccatcatgcc tgcagcatct gtctcaccgc caaagaaatg
    14821 attcagggaa ctgagcggat aataaaggct gatcttctct ttcatatatc caagcttcgc
    14881 ctgttcctct ttgatcacat cgatcagact ggtttctaat ctgttatagt tcatttattt
    14941 tccctcctga aaatctgttc ttttgctttt tctggttaat attttatcag acattgcctg
    15001 aaaatcaatg catttctttt tcaattgtac gcctgtcaaa acaatttcaa tgttttcttt
    15061 ttcatacaaa aataaagacc ttgcgaaact gtcctttttt tctccctctg acaaatcact
    15121 ctggctgaat gaaacaaagc agacaaaacc atccccttcg ttgctttttt aaccaaataa
    15181 ctgcttgatt cggttaaaaa aaacagcgtt ccaaatatta tttatatccg aaacgctgtc
    15241 attattccaa ttatttcatt atgtatttaa tcccagttct tacgtccgta acgaagtgtc
    15301 acatcatata tttccttctg gagtttcttt gtaagatctc tcttcttgat tctccacttc
    15361 cagttcgtac caactgtaga tggtttattc attcggaatc tgttgtccag tcccatatag
    15421 tcctgcattg ggataacgca gacacgcgca gcactgcgca tgatcagact gatgaaacat
    15481 ttatacagtt cttcttccgg tgttgcatga tcacacagat aatctctcgc cagttttctc
    15541 tcagctgctg tgatactatt ccaccatccc acgatagttt cattatcatg ggttcctgta
    15601 tacgccacgc aattctccgg atagttatgt ggcagataat cactggcaca tccggaatct
    15661 ctggagtcaa acgcaaattc cagaaccttc attcccggga atccgctctc atataccaga
    15721 tgacgtacgg aatctgtcat atatcccaag tcctctgcga taacctgctt ccatccaagc
    15781 gcctgttcaa tcttacggaa cagatcaatt ccgggaccct tttcccagtg tccgcctctt
    15841 gcatctttat ctccgtatgg aatagagaaa tattcatcaa atccacggaa atgatcgatt
    15901 cgcacaacat catacagtct gaagcaataa ctcattctgg aaatccacca ctgatatcct
    15961 gtatttctgt gataatccca gcgatataac ggatttcccc ataactgacc ggttgcagaa
    16021 aatccatccg gagggcatcc tgctactgcc attggtacat tatcctgatc cagctggaac
    16081 agctccggat gcgcccatgc atcagcactg tccattgcaa cataaatcgg aatatctcca
    16141 atgatctgga ttccttttga atttgcatag gatttcagtt tcatccactg ctcatagaac
    16201 ttaaactgca tatactgctg gaattcaata tcaaaataga gttcttcacg ataataatcc
    16261 atggcattgt tccagcggag tctgatatcc tcagcccatt tggtccattc tacaccttcg
    16321 aaacggtctt ttactgccat aaacagagca taatctgaca gccaccagct gttctctgct
    16381 acgaatttct gatagtcaag attcttgctg atatcactgt tctcgtatgc ttttctcaga
    16441 agaggataac ggcctttgta gattttttca taatctacct catcaggctt ctttccccaa
    16501 ttaactttct cgcagtcttt cttatcaaga actccttctt ccacaagtgt atccagatca
    16561 ataaaatatg gattacctgc aaatgtagag aaagactgat atggagaatc tccatagctg
    16621 gtcggtccca atggcagaat ctgccagtaa gtctgtccgg cttcctttaa ccagtctaca
    16681 aattcatatg cacttttgga aaaacatccg atgccatagt ctgatggaag actgctgatc
    16741 ggcattaata ttcctgctgc tctttttccc
//
