LOCUS       gnlProkkaFOBFLDAG_64   15313 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FOBFLDAG_64.
ACCESSION   gnlProkkaFOBFLDAG_64
VERSION     gnlProkkaFOBFLDAG_64
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 08:06:28
            Original ID  :: gnl|Prokka|FOBFLDAG_64
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15313
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15313
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4783:6555]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4784..6555
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..15313
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15313
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             441..1187
                     /locus_tag="ctg64_1"
                     /transl_table=11
                     /translation="MYQFFIQPDSIKEEEIWIADPQDVNHIRNVLRMKKGEKVSLCCEA
                     KGKEYICSIEEIESDIVKAAIIDINGESRELPVKITLFQGLPKSDKMELIIQKAVELGA
                     AEIVPMATKRAVVKLDAKKAAKKVQRWNEIAKSAAKQSKRGLIPEVKPVMSFKEAVEYG
                     KSMDMLLIPYEDAKGIAHSREVVETVKDKKSLGIYIGPEGGFPEEEVSFAMKAGAEPVT
                     LGHRILRTETAGMTLLSILMFMLEED"
     CDS             1274..2383
                     /locus_tag="ctg64_2"
                     /transl_table=11
                     /translation="MAGSSFGTLFCMTTWGETHGKGVGVVVDGCPAGLSLCEEDIQKYL
                     NRRKPGQSKYTTKRKEDDKVEILSGVFEGKTTGTPISMAVFNKDQHSKDYSAIKDIYRP
                     GHADYTFDKKYGFRDYRGGGRSSGRETTARVAAGAVAAKVLKELGIEVFAYTKAIGPVQ
                     IDENRFSKEERDKNALYMPDAQAAAQAEEYLQEKMKELDSCGGIVECVITGMPVGVGEP
                     VFDKLSANLGKAILSIGAVKGFEIGDGFAAAASAGSENNDDFYNDNGTVKKKTNHAGGV
                     LGGMSDGSVITFRAAFKPTPSIAQPQQTVNRDGKDTEIVIHGRHDPIIVPRAVVVVETM
                     AAVTVLDLLLQNMGSRLDSVKNFYENEKK"
     CDS             2452..3594
                     /locus_tag="ctg64_3"
                     /transl_table=11
                     /translation="MYKLLTKDGMAKRGEFETVHGTIQTPVFMNVGTVGAIKGAVSTDD
                     LRTIGTQVELSNTYHLHVRTGDKLIKQFGGLHKFMGWDKPILTDSGGFQVFSLSGLRKI
                     KEEGVYFQSHIDGHHIFMGPEESMQIQSNLGSTIAMAFDECPSSRADRTYIQNSVDRTT
                     RWLERCKKKMQELNSLPDTVNPHQMLFGINQGGVFADIRIEHAKRISELDLDGYAVGGL
                     AVGETHDEMYYILDEVVPYLPENKPTYLMGVGTPANIIEAVDRGIDFFDCVYPSRNGRH
                     GHVYTHHGKLNLFNKKFELDPRPIEEGCQCPSCRTYSRAYIRHLLKAKEMLGMRLCVLH
                     NLYFYNHLMEEIRGAIDEHRYKEFKKTTLEGFLTPEEEYR"
     CDS             3628..3948
                     /locus_tag="ctg64_4"
                     /transl_table=11
                     /translation="MLLAQSASASSSITMIIAYVILFGAIIYFMTIRPQKKQQKAADEM
                     HAGMQAGDSVLTTSGFYGVIIDIMDDTVIVEFGNNRNCRIPMQKDAIAAVEKPNLTKTE
                     EE"
     CDS             4304..4684
                     /locus_tag="ctg64_5"
                     /transl_table=11
                     /translation="MDGISYKKWMERAAGLFLSALIAVLLTMLFLAVFAFAMLKGNLSA
                     SVEKIGLIVMSVMACFVGGFLCGKKNMKKRYLWGLGVGVLYCLFFGVIRVGMGQAFVTD
                     TTAFFTMMLYCAAGGMLGGMLS"
     CDS             4784..4930
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_6"
                     /sec_met_domain="TIGR03973 (E-value: 5.4e-23, bitscore:
                     70.6, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 2.7e-22, bitscore: 68.4,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVKTLTGNKTYGTTMCKGGCGECQTSCQSACKTSCTVGNQTCE
                     SNK"
     CDS             5191..6555
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_7"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 1.6e-33,
                     bitscore: 104.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.5e-16, bitscore: 49.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3e-14, bitscore: 43.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.6e-20, bitscore:
                     63.3, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQYKNNGYNIVMDVCSGAIHVVDDVTYDVIALYEEKSLEEIEN
                     ELSYSKEDIEEAYKEVTSLKEEGLLFTEDIYEDYIKEVKSRKTVVKALCLHIAHDCNLA
                     CRYCFAEEGEYKGHRELMSAKVGKAALDFLVANSGNRHNLEVDFFGGEPTMNFGVVKEV
                     VEYGRSLEEKHNKHFRFTLTTNGVLLNDEIMEFANKEMDNVVLSVDGRKEIHDYMRPTR
                     NGKPSYDLIMPKFIRFAESRHQQKYYVRGTFTNRNLDFSKDVLHLADLGFEQISMEPVV
                     GQPEEPYAIQEKDLPQIFDEYDRLAKEMIKREKAGKGFNFFHFMIDLTGGPCVAKRLSG
                     CGSGTEYLAVTPWGDLYPCHQFVGEEKFLLGNVFDGIKRTDICDEFRSCNVYTKKKCKD
                     CFARFYCSGGCPANSYNFHGTIDDSYDLSCDMERKRVECAIMIKAALADTEGEEE"
     CDS             6556..8331
                     /locus_tag="ctg64_8"
                     /transl_table=11
                     /translation="MEKWFIASKRADFNKIGEIFHISPVTARLMRNRSLTTVKEMQRYL
                     YGSLSDLYDSHLLKDADKGAEIIKEKIETGKKIRIISDYDVDGVSSNYILYQGLKRCGA
                     DVDYKIPDRVEDGYGINEHLIEKAAGDGIDTIITCDNGIAAAEQIAYGNSLGLTLIVTD
                     HHDIPFQRQEDGSISYNLPSAAAVINPKQKDCPYPFENICGAVVVYKFIQVLYDLFGID
                     RRESEAFLEIAAMATVCDVMPLCDENRIIVKEGLRRIQHTNITGLQALIEANHLEEKKI
                     SSYHFGFILGPCINASGRLTSAKDALELLLCEDKELCRQKAEALTQLNTERKEMTANGV
                     KAAKEYLESTGHANDKVLVVYLPNCHESIAGIIAGRMKEHYHKPVFVITRTKEGLKGSG
                     RSIEAYHMYKEMNKIKECFDKFGGHPMAAGFSMQEDRLEEFREKLNANATLTEDDFAEK
                     VHIDVALPISYLSESLINEFELLEPFGNENTKPLFAQKDLYIKGMRVLGTTGRCLKLFL
                     SDANGTSIDAMYFGESDVFLEELISFCGKEEAQRIQKGLSHHIWMDVTYYPQVNEWRGQ
                     KNIQIVIQNYRFKNL"
     CDS             8502..9347
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179:hydrolase (Score: 177.4; E-value: 6.7e-54)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg64_9"
                     /transl_table=11
                     /translation="MEQEKKQPDVRLIGLDLDGTTLTSDKVLTPHTKEVLEKCLAEGIQ
                     VLPATGRVKSGIPEYLTQIEGMRYVILSNGASVLDLKEDKVLYQNCIPWERALELFDVL
                     ETYDTFYDIYALGAGWCEARFYDNVENYGIEKHIEKLVRTSRNRIDDLREWMKENKAPV
                     EKINMFFAKEEDRQRAFRELGKIEDLAVTCSLGNNLEINGATCNKGDAMLNLGKILDIP
                     IESIMACGDGNNDFEMVKMAGVGVAMKNGEESLKEVADFVTKTNDEEGVAYAIEHFCNV
                     "
     CDS             9450..10007
                     /locus_tag="ctg64_10"
                     /transl_table=11
                     /translation="MPDLGAERVDKVKKLEDYVINIPDFPKPGIIFRDITSILRDPEGL
                     KLSVHELMHCLEGTEFDVVVGAESRGFLFGMPLAYNKSKGFVPVRKKGKLPRETVSKEY
                     ALEYGTAEIEIHKEDIRPGQRIVFVDDLLATGGTAKAAIDLIEELGGVVVKVLFVMELE
                     GLHGRDVLKGYDVESVITYPGK"
     CDS             10204..11073
                     /locus_tag="ctg64_11"
                     /transl_table=11
                     /translation="MEHLNLLQRIEKKSSEFSKGQRRLAQYITENYDIAAYLTASKLGK
                     EAGVSESTVVRFAYQLDYEGYPELQKAIQVIVKTNSNSIQRMSLSSKRYQEKGVLKSIL
                     YTDSERLRDTIQSGVDEEEFNRSVMLINDARRLYILGARSAAYLAGLMGYYFKMMFDNV
                     IIVDANSTSETLEQIYDISDKDVMMGITFPRYSKRTICALQYAKNHGAKTIALTDNMQS
                     PIVEYADCKLIAKSDVMTIVDSLVCPLSVVNAMVTAIALLRKDDVEKRLMALEELWNEY
                     DVYNRSLL"
     CDS             11073..12314
                     /locus_tag="ctg64_12"
                     /transl_table=11
                     /translation="MNKVIIVGGGAAGMMAAISASKEGKKACILEKNEKLGKKLFITGK
                     GRCNITNACPADEFLTHVVTNPRFLYSTFSQFNNEDMMDYLEEIGLPIKTERGQRVFPQ
                     SDRSSDVIDALKKQCKKGGVQIYYHTEVKELLFDEEKENCVGVLLSDGKKMMGDSVILA
                     CGGFSYASTGSNGSGYTLAKQAGHKIKSIEPSLVPFEMKEMWCKDLMGLTLKNIGVRIK
                     AKKKTVYEGFGEFLFTHFGVSGPLVLTASTCLGKYQKELEAGELKLILDLKASLTPEQL
                     DKRFLREFDTYRNKNISNVMERLLPKKMIPVFLEEAQIPEDKKIRDISKKERRHMIELM
                     KNFEMHITGVRGFNEAIVTRGGVNVKEINPSTMESKKVKHLFFAGEMMDLDAVTGGYNL
                     QIAWTTGYVAGKNA"
     CDS             12450..13115
                     /locus_tag="ctg64_13"
                     /transl_table=11
                     /translation="MYSIAIDGPAGAGKSTIAKAIAEDIGFIYVDTGAMYRAIALYFLR
                     KGIDGHDRKLVAAECPNIHVTLEYDEEGKQQVILNGENVTGYIRKEEVGKMASVTSAVP
                     EVRAALLDLQRDMAKTSDILMDGRDIGTNVLPDASLKIYLTASADVRAKRRYDELKEKG
                     ADCDIEQIKTDIIARDKQDMEREIAPLCQAEDAILVDSSDMSIPQVIDTIISEFKKIK"
     CDS             13133..15016
                     /locus_tag="ctg64_14"
                     /transl_table=11
                     /translation="MKINIAKSAGFCFGVKRAVDTVYKESSKKNVYTFGPIIHNDEVVA
                     DLERQGVHVINDSEDFKSLSEGTIIIRSHGVSKAIYDEILNAGLDLVDATCPFVRKIHK
                     IVERESGDGRVIIIIGNNHHPEVEGIMGWCHTHPIVIENREQAEGIELDADTKISIVSQ
                     TTFNYNKFQDLVEIISEKGYDINVFNTICNATEERQTEARELAKKSDAMIVIGGRHSSN
                     TQKLFEISKKECSNTFYIQTKNDLNMEDFSNIGMLGITAGASTPNNIIKEVHESMAEMS
                     FDQMLEESFKTIRNGEVVQGTIIDVKEDEIILNIGYKADGIISRNEYSNDQNLDLTTVA
                     KVGDEMEAKVLKVNDGEGQVLLTYKRLKAEKGNKRLEEAFNNHEVLKAPVAKVLDGGLS
                     VVVEETRVFIPASLVSDTYEKNLKKYDGQEIEFVITEFNPRKRRIIGDRKQLLVAEKKA
                     KQEALFAKIEAGMTVEGTVKNVTDFGAFIDLGGADGLLHISEMSWGRVENPKKVFTVGE
                     KLNVLIKDIQGEKIALSLKFPETNPWLHADEKYAVGNEVTGKVARMTDFGAFVELEPGV
                     DALLHVSQIAKEHIEKPSDVLKVGQEVTAKVVDFKKDDRKISLSIKALDNE"
ORIGIN
        1 aattattgtg aacagatgct ttgcatttaa attgaagtta taaaggttga aaagggaaat
       61 tgaggcttac ttcttgctcc aatataatat agtcaagtta aatcatcctc ccctattccc
      121 attcattcta gagtaagcag aagacatcag cttctgtcct caaatccccg cccccctgtt
      181 tgattcatct tctccagcca cagcacagaa gccattgccc ccaataaggc atatttgtgg
      241 tctcggagca aggtttggat gcgagcgggt aagcgaacat tcaaaccgcc gcgactaaaa
      301 tcacaaatat gccttattgg gggcaatggc ttcgtctgta gttcgcttaa tgaattaaat
      361 agtaaattga catatttttt gaaagcggtt atgatatatt atgtctgcct tatagggcaa
      421 agaatgaagt ggaggagttt atgtatcagt tttttataca gcctgatagt attaaagaag
      481 aggagatttg gattgcagac ccgcaggatg taaatcacat tcgtaatgtt ctccgtatga
      541 aaaagggaga aaaagtttct ctttgttgcg aagcaaaggg aaaggagtac atttgtagta
      601 tagaagagat agaatcagat atcgtcaagg cggcaattat tgatattaac ggagagtcga
      661 gagaactgcc ggtaaagatt acgctttttc aaggacttcc aaagagtgac aagatggaac
      721 ttatcattca aaaagcggta gaactcgggg cggcagagat tgtgccgatg gcaacaaaaa
      781 gagcggttgt aaagcttgat gcgaagaagg cagcaaagaa agtacagcga tggaatgaga
      841 ttgcaaaaag tgcggctaag cagtcaaaga gaggtctgat tccagaagta aagcccgtaa
      901 tgtcttttaa agaagctgtg gaatatggaa agagtatgga tatgctactc attccgtatg
      961 aggatgccaa gggaatcgca cattccagag aagtggtaga aacagtaaag gataaaaaga
     1021 gtctgggaat ttatatcgga ccggaaggtg gttttccgga agaagaggtt tcttttgcga
     1081 tgaaagcagg agcagaaccg gttacacttg ggcaccgcat tttgcggacg gaaacggcgg
     1141 gaatgacatt actttctata ttaatgttta tgttagaaga agattgattt ggtgtagata
     1201 gtagaaattt aattgataaa aagtcaaaca gaggatactc tgtttgacga tagaatttta
     1261 acaggaggac aaaatggcag gttcatcatt tgggacattg ttttgtatga caacatgggg
     1321 agaaacacac ggaaaaggtg tgggtgttgt agtggacggt tgtccggcag gcctttctct
     1381 ttgtgaggag gatatacaga agtatttgaa tagaagaaag ccgggacagt caaagtacac
     1441 aacaaagcga aaagaagatg ataaggtgga gattttatcg ggagtttttg agggaaagac
     1501 aacaggaact ccaatttcta tggcggtatt taataaagac cagcattcaa aagattactc
     1561 tgcaatcaag gatatttacc gtccgggcca tgcagattat acatttgata agaagtatgg
     1621 tttccgtgat tatcgcggtg gcggccgttc ttcaggaaga gagacaacag caagagtagc
     1681 agcaggtgca gtagcagcaa aagtattaaa agaacttggc attgaagtat ttgcttatac
     1741 aaaagcaatt gggccagttc aaattgatga aaatagattt tcaaaagaag aacgagataa
     1801 gaacgcatta tatatgccgg atgcacaggc agcagcacag gcggaagagt atcttcagga
     1861 gaaaatgaaa gagttagatt cctgtggtgg cattgtggaa tgtgtaatta caggaatgcc
     1921 cgtcggtgtt ggtgagccgg tatttgataa attaagtgcg aatcttggaa aagcaatttt
     1981 atctatcgga gcagtaaaag gcttcgaaat cggagatgga tttgcggcgg cagcaagtgc
     2041 tggttctgag aataatgatg atttttataa tgataatggt acggtgaaaa agaaaacgaa
     2101 tcatgcaggt ggtgtgcttg gtggaatgag cgatggttca gtaattacat ttcgtgcagc
     2161 atttaagcca actccatcga ttgcacagcc acagcagaca gtaaatagag atggcaaaga
     2221 tacagaaatt gtaattcacg gaagacatga cccgattatt gtgccaagag cagtcgttgt
     2281 tgtagagaca atggcagcgg taactgttct tgatctgctg cttcagaata tggggagccg
     2341 cttagatagc gtaaaaaact tctacgaaaa tgagaaaaaa taaggataga ggttgtacat
     2401 ttgctttgtt tatgataaaa tcaaatttat gtgtaaagtt aaggagagta tatgtataag
     2461 ttattaacga aagatggcat ggccaaacga ggagagtttg agacagtcca tggtacgata
     2521 cagactcctg tttttatgaa tgtaggaaca gtaggagcaa tcaaaggtgc tgtaagcacg
     2581 gatgaccttc gtacaatcgg aacgcaggtg gagctgtcta atacctatca tcttcatgta
     2641 agaacaggtg ataaactaat caaacagttt ggcgggcttc ataaatttat gggatgggat
     2701 aaaccaatcc ttaccgattc tggcggattt caggtgtttt ctctgtcagg tcttcgaaag
     2761 ataaaggaag aaggcgtata tttccagtca catattgatg gacatcatat ttttatggga
     2821 ccggaagaaa gtatgcagat tcagtctaat cttggttcta cgattgcgat ggcatttgat
     2881 gaatgtcctt caagtcgggc agacagaacc tacattcaga attctgttga cagaacaaca
     2941 agatggttag aacgctgtaa aaaaaagatg caggaattaa acagcctgcc agataccgta
     3001 aatccacacc agatgttatt tggtattaat cagggtggtg tttttgcgga tatccgtatc
     3061 gagcacgcta aaagaatcag tgagcttgat ttagatggtt atgcagttgg cggacttgca
     3121 gtaggagaga cacatgatga gatgtactat atccttgatg aagttgttcc gtatctgccg
     3181 gaaaataaac caacttacct tatgggtgta ggaaccccag caaatattat tgaggcagtt
     3241 gacagaggaa tcgacttctt tgactgtgta tatccttcca gaaatggaag acacggacat
     3301 gtgtatacgc atcatggaaa gttaaatctt tttaataaga agtttgaatt agacccccgc
     3361 ccaatcgagg aaggatgcca gtgtccgtca tgtcggacat acagcagagc ctatatcaga
     3421 cacctgctca aggcaaaaga gatgcttgga atgcgtcttt gtgttcttca taacctgtat
     3481 ttctataatc atttaatgga agaaatacgt ggagcaattg atgaacaccg ctacaaagag
     3541 ttcaaaaaaa ccacattaga aggttttttg acaccggaag aagaataccg gtaatatatt
     3601 atatagaaga ataacggagg taaggacatg ttattagcac agagtgcgag cgcaagctca
     3661 tctattacaa tgatcattgc atatgtcatt ctttttggag cgattatcta ctttatgaca
     3721 atccgtccac agaagaagca gcagaaagca gcagacgaga tgcatgcagg aatgcaggct
     3781 ggagacagcg tattgactac aagcggattc tatggcgtaa tcatcgacat catggatgac
     3841 actgtaatcg tagaatttgg taacaaccgt aactgcagaa tcccaatgca gaaagatgct
     3901 attgcagcag tggagaagcc aaatcttaca aagacagaag aagagtagtt tcggttagcg
     3961 ggacagacga aaaatgaaaa agcagatatc ctatatttgt gactctatca ctgcgggttg
     4021 aatgttcgcc tccgggttca cattcaatcc tcgctaaggc cacaaatata ggatatctgt
     4081 tttttgctaa attgaaagta ctctccagtt taacaaagac agaaattaag agaccgccaa
     4141 tatataaaaa atgcgcctta gagcaagctc ttaatgcgga cgagcattaa gagcgcagtg
     4201 atacgaagca ttttttatat attggcggtc tcttaatttc gtctcgcttg ttctaaacag
     4261 agaacccttt tcataggcta taaaaaagcc tttggtgcag cctatggatg gaatttcgta
     4321 taaaaaatgg atggagcgtg cagcaggcct gtttctttct gcattaattg cagtattact
     4381 cacaatgcta tttttagcag tgtttgcatt tgccatgttg aaaggtaatc tttccgcttc
     4441 cgtagaaaaa attggtttaa ttgttatgag tgtgatggct tgttttgtcg ggggattttt
     4501 gtgtgggaaa aagaatatga aaaaacggta tttatggggg cttggcgtag gtgttttata
     4561 ttgcttgttt tttggagtaa tacgcgtcgg gatggggcag gcatttgtga cagatacgac
     4621 agcatttttt acaatgatgc tttattgtgc ggcaggagga atgcttggag gaatgttaag
     4681 ctaaaaagtt cttttcttac gggagggttt gtgttataat aacctacaaa gtgtcatctt
     4741 agatgcttta catactagat catgaagtga ggaggcgtta ttaatgaaac gtgtaaagac
     4801 actgaccgga aacaaaactt acggtactac aatgtgtaaa ggtggatgtg gcgagtgcca
     4861 gacatcctgc cagtctgcct gcaagacatc ttgtacagta ggtaaccaga cttgcgagag
     4921 taataaataa ttagagagca caacaggaag aatgcttcct gatatatgct tgaagtaggg
     4981 tgaactgtct tttttgtcag ttcaccttat ctcttgtatg gaaaagtatg tttgcagaga
     5041 ttactttatt gtaagttgaa aatattgtat acaggaatgt tctgtattat atatctattt
     5101 taaagttagc aggacatatc ttcaaattaa aaatatattt tagaaaatta agtataaaaa
     5161 ctataaaaga aatagaaagg gatatttaac gtgattcacc agtataaaaa taatggatat
     5221 aatattgtca tggatgtgtg cagtggtgcc attcatgttg ttgatgatgt gacttatgat
     5281 gtcattgctt tatatgaaga aaaaagctta gaagaaatag aaaatgaact ttcttacagc
     5341 aaggaagata ttgaggaagc atataaagag gtaacttctt taaaagaaga gggactttta
     5401 tttacagaag atatttacga agattatatt aaagaggtaa agagcagaaa gacagtagta
     5461 aaggcacttt gcctgcatat tgcacatgat tgtaatcttg cctgccgcta ctgttttgca
     5521 gaagaaggag agtataaagg acaccgtgaa cttatgagtg caaaggttgg aaaggctgcc
     5581 cttgatttcc ttgtagccaa ttctggaaac cgtcataatc ttgaagttga cttctttggc
     5641 ggtgagccaa caatgaactt cggtgttgta aaggaagttg tagaatatgg acgttctctt
     5701 gaagaaaaac ataacaaaca tttccgtttc actttgacaa ccaatggtgt gctgttaaat
     5761 gacgagatta tggaatttgc caataaagaa atggacaacg ttgttttaag tgtcgatgga
     5821 cgtaaagaaa tccatgatta catgcgtcct acaagaaatg gtaagccaag ctatgacctt
     5881 atcatgccga agtttattcg ttttgcagag tccagacatc agcagaaata ctatgtaaga
     5941 ggaacattta ccaatagaaa tcttgatttc tccaaagatg ttcttcatct tgcagactta
     6001 ggatttgaac agatttccat ggaaccagtt gttggacagc cagaagagcc atacgcaatt
     6061 caggaaaaag accttccaca gatttttgat gagtatgaca gacttgcaaa agaaatgatt
     6121 aagagagaaa aagcaggaaa aggctttaat ttcttccact ttatgattga ccttacaggt
     6181 ggtccatgtg tagcaaaaag actttccggc tgtggaagcg gaacagagta tttagcagta
     6241 acaccatggg gagatttata tccttgccac cagtttgtag gagaagagaa attccttctt
     6301 ggtaacgttt ttgatggaat caagcgtacc gatatttgtg acgaattccg ttcctgcaac
     6361 gtatacacaa agaaaaaatg taaagactgt tttgcgagat tctactgtag cggcggctgt
     6421 cctgcaaact cttataattt ccatggaaca attgatgatt cttatgattt aagttgcgat
     6481 atggagcgta agagagtaga atgcgcaatt atgattaagg ctgcattagc agatacagaa
     6541 ggcgaagaag aatagatgga aaagtggttt atcgcttcaa aaagagcaga ttttaataaa
     6601 attggtgaga tatttcatat cagcccggta acggcgcgtc tgatgagaaa taggagctta
     6661 acaacagtta aggaaatgca gcgttatctt tatggctctc tgtctgattt atatgattct
     6721 catcttttga aagatgccga taagggagcg gaaatcataa aagagaagat agaaacaggc
     6781 aaaaaaattc ggattatttc ggattatgat gtagatggtg tttcatcaaa ctatatttta
     6841 tatcagggat taaaacgctg tggtgcggat gttgattata agattcctga ccgtgtggaa
     6901 gacggttatg gaattaatga acatctgata gaaaaggcag caggggacgg aattgatacg
     6961 attatcacct gtgacaatgg aattgcggca gcagaacaga ttgcttatgg aaattcttta
     7021 ggactcaccc tgattgtgac agatcatcat gatattccgt ttcaaaggca agaagatgga
     7081 agtatttctt ataatttgcc gtcagccgct gccgttatta atccgaagca aaaagattgt
     7141 ccgtatccat ttgaaaatat atgcggagcg gttgttgtct acaagtttat tcaggtgctt
     7201 tatgatttgt ttggaattga ccgtagagaa agtgaagcat ttcttgagat tgcggcgatg
     7261 gcaacagtct gtgacgttat gccattgtgt gatgagaacc gtattatcgt aaaggaaggc
     7321 ctgcgacgga tacagcatac gaatattacc gggctgcaag ctttaattga ggcaaatcat
     7381 cttgaagaaa aaaagatatc ttcttatcac tttggattta ttctcggtcc gtgtattaat
     7441 gcttccggtc gtttgacctc tgcaaaagat gcgttagaac ttcttctatg cgaagataaa
     7501 gaactttgca ggcagaaagc agaagcactc acacagctaa atacagagcg aaaagaaatg
     7561 acagctaacg gggtaaaagc tgcaaaagaa tatctcgaaa gcaccggaca tgcaaacgat
     7621 aaggtacttg ttgtatatct tccaaactgt cacgaaagta tcgccggaat tattgccgga
     7681 agaatgaaag aacattacca taagccagta tttgtcatca caagaacaaa agaaggatta
     7741 aaaggctctg gccgttctat cgaagcctat catatgtata aggaaatgaa caaaatcaag
     7801 gaatgtttcg ataaattcgg tgggcacccg atggcagcag gattttctat gcaggaagac
     7861 cgcttagaag aattccggga aaaattaaat gccaacgcaa cccttaccga agatgatttc
     7921 gcagaaaaag ttcacattga tgtagccttg ccgatatctt atttatccga aagtctcatc
     7981 aatgaatttg aattactaga accatttgga aatgaaaaca caaaaccgct ctttgcacaa
     8041 aaagaccttt acataaaagg aatgcgggta ctcggaacaa caggcagatg tttaaaactc
     8101 ttcctgtcgg atgccaatgg aacaagcata gatgccatgt attttggaga atccgatgta
     8161 tttttagaag aactcatctc tttttgtgga aaagaagagg cacagagaat tcaaaaaggc
     8221 ctgtcacatc atatatggat ggatgtgact tattatccac aggtaaatga atggcgaggg
     8281 cagaagaata tccaaatcgt catccagaat tatcgtttta aaaatttatg agataaattt
     8341 tttagtgctt ctttcgcata ttttttcgtc tgtttagatt cccaattaat aaaaaactat
     8401 cctaatttga caaataaggc gagaatcaat agaataatat gaggatgaaa agagagatac
     8461 atcaaaatcg ctatgaatta agagatagat aaggagaaaa tatggaacag gagaaaaaac
     8521 agccagatgt cagattgata ggattagatt tagatggaac aacgctcact tcagataagg
     8581 tgttaactcc acatacaaag gaagtacttg agaaatgtct tgcggaaggg attcaggttt
     8641 taccggcaac aggaagagta aaatcgggta ttccagaata tttaacacag attgaaggaa
     8701 tgagatatgt tattttatcc aatggtgcaa gtgtattaga tttaaaagag gataaagttc
     8761 tttatcagaa ttgtattccg tgggagagag cattggagtt attcgatgtg ttagaaacat
     8821 atgatacatt ttatgatatt tatgcattag gagctggctg gtgtgaggct cgcttttatg
     8881 ataatgtaga aaactatgga attgagaaac atatcgagaa gctggttcgt acatcacgca
     8941 atcgtattga tgatttaaga gagtggatga aagaaaataa agctccagtg gagaagataa
     9001 atatgttctt tgcaaaggaa gaagacagac agagagcttt ccgtgaactt ggaaagatag
     9061 aagatttggc ggttacctgt tctcttggta ataatcttga gattaatggg gcaacttgta
     9121 ataaaggaga tgcgatgctc aatcttggaa aaattcttga tattccgata gaaagtatta
     9181 tggcgtgcgg cgatggcaat aacgattttg agatggttaa gatggctggt gtcggtgttg
     9241 ctatgaaaaa cggagaagag tctttgaaag aggttgcaga ttttgtgaca aagacaaatg
     9301 atgaggaggg cgtagcatac gctatcgagc atttttgtaa tgtgtaagta gaaataaacg
     9361 tttttctgtt gttttttaca taaaaaatct gttataatta atcataagaa gaaaaagcgc
     9421 gaagataaaa gtctgtgctt aatagtttta tgcctgattt gggggcagaa agggtggaca
     9481 aagtgaaaaa acttgaagat tatgtcatta atattccaga tttcccaaag ccgggaatta
     9541 ttttcagaga tattacctct attttacgtg atccggaggg actgaaactt agcgtacatg
     9601 aattgatgca ttgcttagag ggaacagagt ttgacgtagt tgttggagcg gaatcccgtg
     9661 gatttttatt tggtatgcct cttgcttaca ataaaagcaa gggatttgtt cctgtccgta
     9721 agaaaggaaa gctgccaaga gagactgtaa gcaaagaata tgctttagag tatggaacag
     9781 cagagattga aatccataaa gaggacattc gtccgggaca aagaatcgta tttgtggatg
     9841 accttttagc aactggtgga acagcaaagg ctgcgattga tctgatcgaa gaacttggtg
     9901 gcgttgtcgt aaaggttctg tttgttatgg aacttgaggg attgcatggc cgtgatgtat
     9961 taaaaggcta tgatgtagag tctgttatta cttatcctgg aaagtaattt tgaaggaaaa
    10021 gaaactgtgt gatggaattt tttggaagca cagtttctct ttgtgtaaaa attgttctgt
    10081 agttataaag ttgaatttct atttgcaatt tctttcttta aatcctgcat tttgctttac
    10141 aaaaagaaga aaatggagta ttatgaaata tacttaattt tacagaatag gtggaagaat
    10201 agagtggaac atttaaattt attacagaga atagagaaga agtcttccga gttcagtaaa
    10261 ggacagagaa gactggctca gtatattaca gagaactatg atattgcggc gtatcttacc
    10321 gcttcaaagc ttggaaagga agcaggagtc agtgagtcta cagtggttcg ttttgcttat
    10381 cagcttgatt acgagggata tccagagcta cagaaggcaa ttcaggttat tgtaaagaca
    10441 aattcaaact ccattcagag aatgtccctt tcctcaaaaa gatatcagga aaaaggtgta
    10501 ttaaagagta ttttgtatac agattcagag aggcttcgcg atacgattca gagcggtgta
    10561 gatgaggaag aatttaacag atccgttatg cttatcaatg acgcaagaag attatatatt
    10621 ttaggtgcga gaagtgcagc ctatcttgcc ggtctgatgg gatattattt taagatgatg
    10681 tttgacaatg taattatcgt agatgccaac agcacgtccg agacattaga gcagatttac
    10741 gatatcagtg ataaggatgt tatgatggga attacttttc caagatattc aaagagaacc
    10801 atctgtgcgc ttcagtatgc gaagaatcat ggagcgaaga caatcgcact taccgacaat
    10861 atgcagtctc caattgtaga gtatgcagat tgtaaattaa ttgcaaagag tgatgtaatg
    10921 acaatcgtgg attctttagt atgtccgtta agtgtggtga atgcgatggt tacagcgatt
    10981 gcattgcttc gtaaggatga tgtagagaag cgtcttatgg cacttgaaga actctggaac
    11041 gagtatgatg tttataacag gagtttacta taatgaacaa agtaattatt gtaggcggag
    11101 gggcagccgg tatgatggct gccatttctg cgtctaaaga ggggaaaaag gcctgcattc
    11161 ttgaaaagaa cgaaaaactt ggcaagaagc tttttattac ggggaaaggc agatgcaata
    11221 ttacaaatgc ctgcccggca gacgaatttc ttacccatgt ggtaacaaat ccaagatttt
    11281 tatacagtac attttcgcag tttaataatg aggatatgat ggactattta gaagaaatcg
    11341 gtcttccgat aaagacagag agaggacaga gagtatttcc acagtccgac cggtcttcgg
    11401 atgtaattga tgcattaaag aaacagtgta aaaaaggcgg ggtacagatt tactatcaca
    11461 cagaagtaaa agaactgctt tttgatgaag aaaaagaaaa ctgtgttggt gtactcttgt
    11521 ctgacggaaa gaaaatgatg ggagattctg ttatccttgc ctgcggcggc ttttcctacg
    11581 cttctaccgg ttccaatgga tcgggatata cacttgcaaa gcaagcagga cataagatta
    11641 agtctataga accatcttta gttccatttg agatgaaaga aatgtggtgc aaagatttga
    11701 tgggacttac tttaaagaat ataggggtgc gtatcaaagc aaagaaaaag acagtttatg
    11761 aaggatttgg agaatttctc tttacgcatt ttggagtgag tggtccgctt gttcttacag
    11821 caagtacctg tcttggcaaa tatcagaaag agttagaggc aggtgaatta aaactgattc
    11881 ttgatttaaa agcctctctt accccggaac agttagataa acggttttta agagaatttg
    11941 acacttatcg taataaaaat atttctaatg tgatggaacg tcttcttcca aagaaaatga
    12001 ttcctgtttt cttagaagaa gcacagattc cggaagataa aaagataaga gacatcagca
    12061 aaaaagaaag aaggcatatg attgagctga tgaagaattt cgagatgcat atcacaggag
    12121 tccgtggctt taatgaggca atcgtcacga gaggcggagt aaatgtaaaa gaaattaatc
    12181 cgtctacaat ggagtctaaa aaagtaaaac atttattttt tgccggagaa atgatggatt
    12241 tagatgctgt cacaggcggc tataacctgc agattgcatg gacaacaggc tacgtagcag
    12301 gcaaaaatgc gtaaagaaaa cgtaaaattt aaaaaattat aaaaaaatag tttttttttt
    12361 cggaaaaata tgttacacta atcaagtgta ggtaaaagtg aaatcactgt atacgcagtc
    12421 aggtttcaaa agaatgggag gaaatgtcca tgtacagtat agcaattgat gggccagcag
    12481 gagctggaaa gagcacgatt gcaaaggcaa tcgcagaaga tataggtttt atatatgtag
    12541 ataccggagc aatgtaccgg gcaatcgctt tatatttttt gcgtaaaggt attgatggac
    12601 atgacaggaa gctcgttgcg gcagaatgtc ctaacattca tgtaacttta gaatatgacg
    12661 aggaagggaa acagcaggtt atcttaaatg gtgagaatgt taccggatat atccgtaagg
    12721 aagaagtcgg taagatggca tcagtgacat ccgctgttcc ggaagtaaga gctgcactgc
    12781 ttgatctgca gcgcgatatg gcgaagactt cggatatcct catggatgga agagacattg
    12841 gaacgaatgt cctgccagat gcatctctta agatttatct gacggcctct gctgatgtaa
    12901 gagcgaagag acgttatgac gaattgaaag agaaaggtgc agactgtgat atcgagcaga
    12961 ttaagaccga tattatagca agagataagc aggatatgga gagagagatc gctccattat
    13021 gccaggcaga agatgccata ctggtagatt cttctgatat gtcaattccc caggtgattg
    13081 atacgattat ctccgaattt aaaaaaataa aataatattg ccggagtaaa tgatgaaaat
    13141 taacatagca aaatctgctg gcttttgttt tggagtaaag agagctgtag ataccgtgta
    13201 taaagaatct tctaagaaga atgtttatac attcgggccg atcattcaca atgatgaagt
    13261 tgtcgcagat ctggaaagac aaggggttca tgtcatcaat gacagtgaag atttcaagtc
    13321 tctttcagag ggaacgatta ttattcgttc tcacggcgtg tcaaaagcaa tttatgatga
    13381 gatccttaat gcgggtcttg atttagtgga tgcgacctgc ccttttgtga gaaagattca
    13441 taaaatcgtc gagcgggaga gtggggatgg cagagtaatc attattatag gcaataacca
    13501 tcatcctgaa gtagaaggga ttatgggttg gtgccatacg catccgattg taattgagaa
    13561 tcgagagcag gcagaaggaa ttgagttaga tgctgatacg aagatatcta tcgtgtccca
    13621 gacgacattt aactacaata agtttcaaga tttagttgaa attatctcag aaaagggtta
    13681 tgatataaat gtttttaaca cgatttgtaa tgcgactgag gagcgtcaga cggaagccag
    13741 ggaactggcg aagaagtccg atgcgatgat agtaatcggt ggcagacaca gttcgaatac
    13801 tcaaaaactt tttgagataa gtaaaaaaga atgtagtaat actttttata tacaaacaaa
    13861 aaatgatttg aatatggagg atttttctaa tatcgggatg ctcggtatta ctgcaggggc
    13921 ttcaacccca aataatatta tcaaggaggt tcatgaaagc atggcagaaa tgagttttga
    13981 ccagatgctg gaagaaagtt ttaagacaat cagaaatgga gaggtagttc agggtactat
    14041 tatcgatgta aaagaggatg aaatcatctt aaatattgga tataaagccg acggtatcat
    14101 ttcaagaaac gaatattcca acgaccagaa tttagactta acaacagttg ctaaagttgg
    14161 tgacgagatg gaagctaaag ttcttaaagt gaatgatggc gaaggacagg ttctcttaac
    14221 atataagaga cttaaagcag aaaaaggtaa taagagatta gaggaagcat ttaacaacca
    14281 cgaagtatta aaagctcctg tagctaaagt tcttgatggt ggtttaagtg ttgtagtgga
    14341 agaaacaaga gtattcatcc ctgcaagcct tgtatccgat acttacgaga agaacttaaa
    14401 gaaatatgac ggacaggaaa tcgagttcgt tattacagag ttcaaccctc gcaagagaag
    14461 aatcatcggt gaccgtaagc agcttttagt agcagagaag aaagcaaaac aggaagcact
    14521 gtttgcaaaa atcgaagctg gtatgactgt agaaggaact gtaaagaacg taacagattt
    14581 cggtgcattc atcgatttag gtggagcaga cggacttctt cacatctctg aaatgagctg
    14641 gggacgtgtt gagaatccta agaaagtttt cacagtaggt gaaaaattaa acgttcttat
    14701 caaagatatc cagggagaaa agattgcatt atccttaaaa ttccctgaaa caaacccatg
    14761 gcttcacgct gacgaaaaat acgcagtagg taacgaagta actggtaaag ttgctcgtat
    14821 gacagacttc ggtgcattcg ttgaattaga gccaggcgta gatgcattac ttcatgtttc
    14881 tcagattgct aaagagcaca tcgagaaacc atctgatgta ttaaaagtag gtcaggaagt
    14941 tacagctaaa gttgtagatt tcaagaaaga tgatcgtaag atcagcttaa gcatcaaagc
    15001 tttagataac gaataatatt tagcggaatt tggctaggta gacgaaaata aaaaagactt
    15061 ataatagcac ctgtgacttt agtcgcggcg tgttgaatgt tcgcttaagg gctcgcatcc
    15121 aacacttgct ccgaggtcac atctgctatt ataagtcttt ttcattttct gactttggcg
    15181 caaattccgc tgtggaggat ttgaggattc tccagaagag gatgggagtg ggtggaaaat
    15241 tttcttcgtt atagttaatg tttcactggc attttatata attttgctat aaataaaact
    15301 tcttataagt ata
//
