LOCUS       c00047_gnlPro..        15423 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CLDKADLJ_47.
ACCESSION   c00047_gnlPro..
VERSION     c00047_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 19:36:28
            Original ID  :: gnl|Prokka|CLDKADLJ_47
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15423
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15423
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1111:7229]"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1112..7229
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
     cand_cluster    1..15423
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /kind="single"
                     /product="acetate2butyrate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15423
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="acetate2butyrate"
                     /region_number="1"
                     /rules="(not (POR or POR_N or PFOR_II) and minimum(4,
                     [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF, ETF_alpha,
                     HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and minimum(1,
                     [EC1_2-faecali, ECH1_Enoyl_CoA_DH1, ECH1_Enoyl_CoA_DH2,
                     ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4, Thiolase_C]))"
                     /tool="gutsmash"
     CDS             969..1133
                     /locus_tag="ctg47_1"
                     /transl_table=11
                     /translation="MKILIKNFFIILLQSKEDCDKINTYRTRNALAKQLSNNIDNLNGG
                     MKLWQRKLY"
     CDS             1112..2293
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_2"
                     /sec_met_domain="Thiolase_N (E-value: 4e-104, bitscore:
                     337.3, seeds: 30, tool: rule-based-clusters)"
                     /sec_met_domain="Thiolase_C (E-value: 8.1e-51, bitscore:
                     160.7, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKVVLAGACRTAIGTMGGGLSTVPAADLGSIVIKEALKRTNVP
                     ADQVDEVLMGCVIQAGLGQNVARQASINAGLPIEVPAVTINVVCGSGLNCVNLAATKIL
                     AGEADIVIAGGMENMSLAPFCLDKARFGYRMNNGVLKDCMVNDALTDAFNQYHMGITAE
                     NVAEQWHLTREELDEFSANSQQKATAAIEAGKFKDEIVPVEVKLKKKTVVVDTDEGPRP
                     GTTAESISKLRPAFKKDGIVTAANSSGINDGAACVVVMSEEKAKELGVTPMATWIAGAL
                     GGVDPSIMGVGPVASTKKVLAKTGMSIDDFDLIEANEAFAAQSLAVGRELGINPEKLNV
                     NGGAIALGHPVGASGCRILVTLLHEMQKRDAKKGLATLCIGGGMGCSTIVERD"
     CDS             2424..3209
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: EC1_2-faecali"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_3"
                     /sec_met_domain="EC1_2-faecali (E-value: 5.6e-92, bitscore:
                     297.3, seeds: 67, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFIDYEVDGQVGIITINRPKALNALNSEVLKDLDATIDAVDLDA
                     IRCLIITGAGEKSFVAGADIGEMSTLTKAEGEAFGKAGNDVFRKIETLPIPVIAAVNGF
                     ALGGGCEISMSCDIRLCSENAVFGQPEVGLGITPGFGGTQRLARIVGPGKAKQLIYTAR
                     NIKAAEAYRIGLVNEVYPLEELMPQAKKMAKGIAKNAPIAVRACKKAINEGLEVGMDEA
                     IVIEEKLFGSCFETEDQKYGMAFFLDKNKEKVKEPFKNC"
     CDS             3278..4117
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_4"
                     /sec_met_domain="HCDH (E-value: 8.2e-39, bitscore: 122.1,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="HCDH_N (E-value: 7.1e-62, bitscore: 198.3,
                     seeds: 60, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVGVIGAGTMGSGIAQAFAQTEGYEVYLCDINDEFAANGKKKIA
                     KGFEKRVARGKMDQAKADAILAKITTGTKDICTDADLVVEAALEVMEVKQQTFKELQDI
                     VPATCMFATNTSSLSITQIGAGLDRPVIGMHFFNPAPVMKLIEVIAGLNTPDEMVEKIK
                     AISVEIGKTPVQVEEAAGFVVNRILIPMINEAVGIYADGVASVEGIDTAMKLGANHPMG
                     PLALGDLVGLDICLAIMEVLYNETGDPKYRPHPLLRKMVRGGKLGQKTGIGFYDYSK"
     CDS             4218..5372
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_5"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.7e-52, bitscore:
                     167.5, seeds: 49, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 6.3e-31, bitscore:
                     96.4, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.7e-41, bitscore:
                     131.3, seeds: 796, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTLSKKHEMARQLFKEFAENEVKPLAQEVDETEHFPEETVAKM
                     QKLGFMGIPVPKEYGGQGCDPLTYIMCVEELSKVCGTTGVIVSAHTSLCADPILTYGTE
                     EQKQKYLVPLAKGEKLGAFGLTEPGAGTDAQGVQTKAVLDGDEWVLNGSKCFITNGSYA
                     DYYIIIAITSVDTDARGRKKKKFSAFIVEKGTPGFTFGTKEKKMGIRGSATYELIFQDC
                     RIPKENLLGPMGKGFAIAMHTLDGGRIGIAAQALGIAEGALDATIAYVKERKQFGRAIA
                     AQQNTQFQLANMATQVEAAKLLVYKAAMAKATQRVYSVEAAKAKLFAAETAMDVTTKCV
                     QLLGGYGYIREYDVERMMRDAKITEIYEGTSEVQRMVISGNLLK"
     CDS             5387..6172
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 163.8;
                     E-value: 1.3e-50)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_6"
                     /sec_met_domain="ETF (E-value: 2.7e-51, bitscore: 163.8,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKIVVCVKQVPDTKGGVKFKPDGTLDRAAMLTIMNPDDKAGLEAA
                     LRIKDETGAEVTVVTMGLPKAEEVLREAMAMGADKGILVTDRVLGGADTWATSTTIAGA
                     LRNIDYDLIITGRQAIDGDTAQVGPQIAEHLDLPLISYAQDIKVEGDSVIVQRQYDDRY
                     HVLKAKMPCVITALSELNEPRYMTPGGIFDAYDAEITTWGRKDLKDVDDSNLGLAGSPT
                     QIAKASDKVRKGKGVMMTAETAEEGVEYIMDKLLTKHVI"
     CDS             6162..7229
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF_alpha"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 167;
                     E-value: 1.3e-51)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_7"
                     /sec_met_domain="ETF (E-value: 2.8e-52, bitscore: 167.0,
                     seeds: 129, tool: rule-based-clusters)"
                     /sec_met_domain="ETF_alpha (E-value: 7.9e-39, bitscore:
                     121.5, seeds: 511, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSNCKGNVVNRMNLEQYKGVFIYAQQVDNKIDAIALELLGKAND
                     LAADLGTDVTAVLIGSDVKGLVDELAEYGADKVIVVDDPELKEYRTEPYTHALASVINE
                     YKPDILLVGATAIGRDLGPRVSARVATGLTADCTVLEIGEFKARGDKEPRQGQLLMTRP
                     AFGGNTIATIACPNHRPQMATVRPGVMQKKEPVAGAKAEVIEYNPGFTPNDKYVEILDI
                     VKSVTETVDIQAAKILVSGGRGVGSAENFALLDDLAEALGGTVSCSRAVVDNGWKPKDL
                     QVGQTGKTVRPNVYFAIGISGAIQHVAGMEESDIIIAINKDPDAPIFDVADYGIVGDAL
                     KIVPKLTEAIKAQVK"
     CDS             7848..8138
                     /locus_tag="ctg47_8"
                     /transl_table=11
                     /translation="MAQIIASTKEISNKRESLIVLSNSLKNKISLLETLGNSLNSMWEG
                     AAKEKYVKQLKTDISKMRNLLKTILEFILILEKIIAIYNKAEKKNEATAVS"
     CDS             8150..8467
                     /locus_tag="ctg47_9"
                     /transl_table=11
                     /translation="MADLINVTPEKLKATASSFQQAGKDVKKTTSDMLQLVRGISSSIW
                     SGEASSIYLGKFNGLDADIAKMCKMIEEESQHLTTIAQEYQLAEEQNKQVAATLKNNVI
                     A"
     CDS             8492..9208
                     /locus_tag="ctg47_10"
                     /transl_table=11
                     /translation="MLSVMIFCHDKREGDLIGKICNQCVALIDKEFLRNFIISDEEYHQ
                     VNIEGIQPPDLLVVEITGIEDLCRAKRIRGIFPRGRLLVVSTNQISAESYLIPEVSPDM
                     LLLKPYVYAKACRIIYRSLTWCCKDKCRKKKQEDILKIRTGGEIYCFHYEEIQYLEARD
                     KKIILHVNKYEISFYSSLQKLEKSLPDYFIRCHRSYIVNFMFIQKADLINGEFYLNKKT
                     VIPISQKYKAKLAKML"
     CDS             9317..10657
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AcetylCoA_hyd_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AcetylCoA_hydro"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg47_11"
                     /sec_met_domain="AcetylCoA_hyd_C (E-value: 5.2e-64,
                     bitscore: 204.6, seeds: 181, tool: rule-based-clusters)"
                     /sec_met_domain="AcetylCoA_hydro (E-value: 1e-30, bitscore:
                     97.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFIKEYAQKLVTAEEAVKVVKSHDWVDYGWTTGTPVALDAALAA
                     RADELEDVKIRGGILLREPEIFKVNNVADHFTWNSWHMGGLERKAISKGFAYYSPLKYS
                     ELPRYYRENIKHLNVAMFQVAPMDKHGFFNFGPNASHMMAVCEAADVIIVEVNENMPRC
                     LGGFEEGIHVSRVDYIVEGENPAIGELGAGAPPTEVDKAVAQLIVEEIPDGACLQLGIG
                     GMPNTVGSMIAESDLKDLGVHTEMYVDAFVDIAKAGKITGLKKNIDRGRQVYAFGAGTK
                     KMYDYLDDNPECMSAPVDYTNSAKTIAQIDNFISINNAVDIDLYGQVNAESAGIKQISG
                     AGGQLDFVQGAYLSKGGKSFICCSSTFTSKDGVKHTRIRPTLAEGSTVTDTRPNTHYVV
                     TEFGKVCLKGMSTWERAEALINIAHPDFRDELIKEAEKMHIWRRSNK"
     CDS             complement(10955..11983)
                     /locus_tag="ctg47_12"
                     /transl_table=11
                     /translation="MIAKDDIVIRKAILHILDTNRGECILSNTLLDPGPDLHDFIRNHI
                     YKIVSSDDTKNCEFDPEYSPIYSILETWDESDETSFIETSQAIANKLYIAMGEGLDIPA
                     ADLLFVTFQAEGIIYLALLKMNYKESYTHEVTETPDNPVINTDIIKTHSLLPSATSRIP
                     EAVVINLSDYHIKLLEKKYEINGEKAYYLSENFLVCRTSIPPKKKLNILTRVINNISNK
                     YDGADLKTKMDTKSALQKEYVDNKSFDIEEIGNKLFGKSPEKKSEFDEKMEQYDLQYDN
                     FTVTNESTVKKLEKQVMVTDSGIEISIPMETYNKLANFEVQTDVTGKSTIIIRNIDNLV
                     LK"
     CDS             12045..15422
                     /locus_tag="ctg47_13"
                     /transl_table=11
                     /translation="MRFLIFIYGKSRMKRTQLVSDKRAECHILLPKDDFSLERTVFLQF
                     KNISGEWFIKETDCCHLKTEEFFQMGKRKSDEGIFYKLSRGRKNELSVGGKDLYIQLIR
                     YRNDWSIYKKYKLRDCRIIKEKNIFIMMEKAINRKNSMGISYEYGKWFIEKCGNIEIYI
                     NEILLEKKQQLEFGDVICIGTIYLLFFENYIAVEAGERNIVSDYLEEVVLENEIKGQED
                     VRKKEKREITFHRAPRVMEELKKVSLKVDAPPQVDVQEKKSIFMDIGTIMNLMFPMLGM
                     NLFLIYGMKSEQNQAGIYVYSGLFMAVMSAVCSILWLMISRKYEKREQQKKVNKERLAY
                     RRYLNKKSEYIKVQYERVYKVLQSRYLRADTYLDSPLLDMYLWNRNLYHKDFLMYRIGI
                     GDVEFPMKIEFPEEVFGDEENILWREAKKIKEHYEILHQIPVLLDMGRYSQIGIITKDT
                     IAGMELVRSIILQIALCNCYTEVKIGCIYNKNKVIQSQQWDFCRWLPHIWDANRQKRFI
                     AGNEVEARRLFYDLLQIFKEREEVSISGKAEKILPHYILFVAEEQFLEGEMFSKYILDR
                     GREYGLTVVWLDSMRKKLPNTCKMVLEINGGFTGRYEIERHSQKKEKINFDYTEKNIAE
                     KLIRSISGIKVMEIEEKAGIPEVVDFLGMYDVHTIEELHIKQRWEKNRIFESAKVLIGK
                     KAGDEPFYLDIHERYHGPHGLLAGTTGSGKSEVLQTFILSMAVNFSPEAVCFLLIDYKG
                     EGMSALFSELPHISGKISNLSDGQAYRAMVSIKSENKRRQRIFKECKVNNINDYTRLFN
                     SGSVNEPIPHLLIIIDEFAELKKAEPEFMQELISVAQVGRSLGVHLLLATQKPGGVVDD
                     KIWSNSRFRICLKVQEREDSMDMLHNMDACQITQTGRGYLQVGNNEVYELFQAGWSGAL
                     FQQEDTEVAACLVQTDGTIYKRRKNAEKNREKKITQLQAIKQYIIRFAKEKEYQEGRKL
                     WLEPLSKYIYLDEIHKEMNKKLKEKRQRVDMNKNLEVCVGIFDDPENQEQSIFSLNLME
                     SGHIAICGRSASGKSTFFQTFLFSLLKESTAEEVCLYLLDFNGSGMDIYDLMPQVKQVI
                     KEEEEDKVEELFENIKKEM"
ORIGIN
        1 taagacaccg ccctttcacg gcggtaacat gggttcaaat cccgtaggag tcacttgtgg
       61 cgtcgtagcc aagtggtaag gcagaggtct gcaacacctt catcaccagt tcaaatctgg
      121 tcgacgcctc ttaaaagaga ctaagtgatt agtctctttt tagcatttct ttttaattta
      181 atatcgcggg gtagagcagt ctggtagctc gtcgggctca taacccggag gtcgttggtt
      241 caaatccttc ccccgcaatt tgaggaacat cggtacattg gtatcggtgt ttttttattt
      301 gtttaaactg acgcaatagt aaaacccgct ataagtctat ctgtgacttt agtcgcggcg
      361 tgttgaatgt tcgcttagac gctcgtatcc aacacttgct ccgaggccac agatagactt
      421 atagcgagct ttactattgc tggctttgaa ggaaacaaag taaaaattct tagatgtgca
      481 acgattcgat gttggggaga gtgtgtgaat ttaaaatata gattttttgg tattgatttt
      541 gttaatataa ttacaatgat aaaaacaaat tgcaatacaa aatatacata atttcatcta
      601 cagctatccg ggcaattttc aaatccctcc atatagacat tctaaactaa atccttccaa
      661 cagatagaaa agccagagat actttatgta ccatatgctt tatttcactg tgcaaaatgc
      721 cataaaactc actccaaagc cacatctggc aggtaaagta tctctggttt ttcgtctatt
      781 agccaactca gaatgtctat ttcttcacat atttaggcag ttttttgtat tttgtttcct
      841 tttttcacaa aatcagaaaa ttaatcaata gagaatgtcc atagatataa gaagaaataa
      901 aggtaaaatt aattaaaaca acgatggatt ttgtattcaa aagtgacgaa actgtgaatc
      961 tttcataaat gaaaatatta attaaaaatt tttttataat cttgttgcaa agcaaagaag
     1021 attgtgataa gattaacaca tatcgtacta gaaatgctct agcaaagcaa ctatcaaata
     1081 atattgataa cttaaatgga ggaatgaaac tatggcaaag aaagttgtat tagcaggtgc
     1141 ttgtcgtacc gcaatcggaa caatgggtgg tggattaagc acagtaccag ctgcagattt
     1201 aggaagcatc gtaattaaag aagcgttaaa gagaactaac gtacctgctg atcaggtaga
     1261 cgaagtatta atgggatgtg ttatccaggc tggtcttgga cagaacgttg ctcgtcaggc
     1321 ttctattaat gcaggcttac caatcgaagt acctgctgta acaattaacg tagtttgtgg
     1381 ttccggtctt aactgtgtta accttgctgc tacaaagatt ttagcaggtg aggctgatat
     1441 cgttatcgct ggtggtatgg aaaacatgtc attagctcca ttctgcttag acaaagctcg
     1501 ttttggatac agaatgaaca atggcgtatt aaaagactgt atggttaacg atgcattaac
     1561 agatgctttc aatcagtacc atatgggtat tacagctgaa aacgttgcag aacagtggca
     1621 tttaacaaga gaagagttag atgagttctc cgctaattca cagcagaaag ctacagcagc
     1681 tatcgaagct ggtaagttca aagatgagat tgttcctgta gaagttaaac ttaaaaagaa
     1741 aacagttgtt gtagatacag atgagggacc acgtcctgga acaacagcag aaagtatttc
     1801 taaattacgt cctgctttca agaaagatgg tatcgtaaca gctgccaact cttcaggtat
     1861 taacgatggt gctgcttgtg ttgttgttat gagcgaagaa aaagctaaag aattaggtgt
     1921 aactccaatg gctacatgga tagcaggagc attaggcgga gttgatcctt ctatcatggg
     1981 tgttggacca gttgcttcta ctaagaaagt tcttgcaaaa acaggcatga gcattgatga
     2041 ctttgactta atcgaagcta acgaagcttt cgcagctcag tcattagcag taggaagaga
     2101 attaggaatc aacccagaga agttaaatgt taatggtgga gctattgctc ttggacatcc
     2161 agtaggagca tcaggatgcc gtatcctcgt tacattatta catgagatgc agaaacgtga
     2221 tgctaagaaa ggtcttgcta cactgtgtat cggtggtggt atgggctgct caacaatcgt
     2281 tgaaagagac taatcacgta tagaatgatt acatatatcc gggttcggtt ttcgaatccg
     2341 gttatatcaa ttacatagtt tgtaactatt taattatcta gattgaatag ttagctaatg
     2401 taatctgaaa ggagatacat acaatgggat ttatcgatta tgaagtagat ggccaggttg
     2461 gtattatcac catcaatcgt ccaaaggctt taaatgcttt aaacagtgaa gtattaaaag
     2521 atttagatgc aactattgat gcagtagatt tagacgcaat cagatgtctt atcattactg
     2581 gtgctggaga gaaatctttc gtagcaggtg ctgatatcgg agagatgagt acacttacaa
     2641 aagcagaagg cgaagctttc ggtaaagctg gtaatgatgt attcagaaag attgaaacac
     2701 ttccaatccc tgttatcgca gcagtcaacg gattcgcttt aggcggtggc tgtgagattt
     2761 ctatgagctg tgacatcaga ctttgctctg agaatgcagt gtttggacag ccagaagttg
     2821 gtcttggaat tacacctggt tttggtggaa cacagagact tgctcgtatc gtaggacctg
     2881 gaaaagcaaa acagttaatc tatactgctc gcaatattaa agcagcagaa gcttacagaa
     2941 ttggtctggt taacgaagtt tatccacttg aagagttaat gcctcaggct aagaagatgg
     3001 caaagggtat tgcaaagaac gcacctatcg cagttcgtgc atgtaagaaa gctatcaacg
     3061 aaggtttaga agtaggaatg gatgaagcta tcgtaatcga agagaagtta tttggcagct
     3121 gcttcgagac agaagaccag aaatacggaa tggcattctt ccttgacaaa aacaaagaaa
     3181 aagtaaaaga gccatttaaa aactgctaat taatcaatta tacatattgt attattaatt
     3241 atcggaatac attacatttt ataggaggtt tcagacaatg aaagttggag ttattggcgc
     3301 aggtacaatg ggatcaggta ttgctcaggc attcgcacag acagaaggat acgaagtata
     3361 cttatgtgat attaacgatg aatttgctgc aaacggtaaa aagaaaatcg ctaaaggatt
     3421 tgaaaagaga gtagcaagag gaaaaatgga tcaggctaaa gctgatgcaa tccttgctaa
     3481 aatcactaca ggtacaaaag atatctgtac agatgctgat ttagtagtag aagcagctct
     3541 tgaagttatg gaagttaaac agcagacatt taaggaatta caggatatcg ttcctgcaac
     3601 atgtatgttt gcaacaaata catcttcttt atctattaca cagattggtg caggacttga
     3661 cagaccagtt atcggaatgc atttcttcaa cccagctcca gttatgaaat taattgaagt
     3721 tatcgctggt cttaatacac cagatgaaat ggttgaaaag attaaagcta tctccgtaga
     3781 aatcggcaaa acacctgtac aggtagaaga agctgcagga ttcgtagtta acagaatctt
     3841 aatcccaatg attaacgaag cagttggcat ttatgctgat ggtgttgctt ctgttgaagg
     3901 tatcgacaca gctatgaagt taggtgctaa ccatccaatg ggacctctcg ctttaggaga
     3961 tttagttggt cttgatatct gccttgcaat catggaagta ttatataatg aaacaggaga
     4021 tcctaagtat cgtccacatc cattattaag aaagatggtt cgtggtggaa aattaggtca
     4081 gaagactggt attggattct acgattacag caaataatta aaaaagtgaa tacggccgtg
     4141 gggactatgc tctgcgtctc cacggctttt aaggtggttc tccaccccaa taaccaattt
     4201 attatggagg aatgaaaatg gatttcacat taagcaaaaa gcatgaaatg gctagacagc
     4261 tctttaaaga gttcgctgaa aacgaagtta aacctcttgc tcaggaggtt gacgagacag
     4321 aacattttcc agaagaaacc gttgcaaaaa tgcaaaaatt aggtttcatg ggaattcctg
     4381 tgccaaaaga atatggcgga cagggctgtg atcctttaac atacattatg tgtgttgaag
     4441 agttatctaa agtttgtggt acaacaggtg ttattgtatc cgcacataca tcattgtgtg
     4501 cagatccaat tcttacttac ggtactgaag aacagaaaca gaaatatctt gttccacttg
     4561 caaagggtga aaagttaggt gctttcggtc ttacagagcc aggtgctggt actgacgctc
     4621 agggtgttca gacaaaggct gttttagatg gtgacgaatg ggtattaaac ggatctaaat
     4681 gtttcatcac taacggttct tatgctgatt actatattat catcgctatc acaagtgttg
     4741 atacagatgc aagaggaaga aagaaaaaga aattctccgc atttatcgta gaaaaaggaa
     4801 ctccaggatt tacatttggt acaaaagaaa agaaaatggg tatccgtggt tcagctacat
     4861 atgaattgat tttccaggat tgtcgtattc ctaaagaaaa tcttcttgga cctatgggca
     4921 aaggtttcgc aatcgctatg cacacattag atggtggacg tatcggtatt gcagctcagg
     4981 ctcttggtat cgcagaaggt gctttagatg ctacaattgc ttatgttaaa gaaagaaaac
     5041 agtttggcag agcaattgct gcacagcaga atacacagtt ccagcttgct aatatggcta
     5101 cacaggtaga agctgctaag ttacttgttt ataaagcagc aatggcaaaa gcaacacaga
     5161 gagtatactc cgtagaagca gcaaaagcta aattatttgc agcagaaaca gctatggatg
     5221 taacaactaa gtgtgttcag ttacttggtg gttatggtta catcagagag tacgacgtag
     5281 aacgtatgat gcgtgacgct aagatcacag aaatctacga aggaacatca gaagttcagc
     5341 gtatggttat ttctggtaac ttattgaaat aaggagggaa aatactgtga aaatcgtagt
     5401 atgtgttaaa caggtacctg atacaaaagg tggagttaag tttaaaccag acggaactct
     5461 tgatagagca gctatgctta ctatcatgaa tccagatgat aaggcaggtc ttgaagctgc
     5521 ccttagaata aaagatgaaa caggcgcaga agtaacagta gttactatgg gtcttccaaa
     5581 agcagaagaa gttctgcgtg aagctatggc aatgggtgct gacaagggta tccttgtaac
     5641 agaccgtgtt ttaggtggag ctgatacatg ggcaacatct acaacaatcg ctggagcact
     5701 tagaaatatt gattatgatt taatcatcac aggtcgtcag gctatcgatg gtgatactgc
     5761 tcaggtagga cctcagattg ctgaacactt agatcttcct ttaatttcct atgctcagga
     5821 tatcaaagtt gaaggtgaca gtgtaatcgt tcagagacag tatgacgaca gatatcatgt
     5881 tttaaaagct aaaatgccat gtgttatcac agcactttcc gaattaaatg agccacgtta
     5941 tatgactcca ggcggaatct ttgatgcata tgatgcagaa attactacat ggggaagaaa
     6001 agaccttaaa gatgttgatg acagcaactt aggtcttgca ggttctccaa ctcagatcgc
     6061 aaaagcttct gataaggtac gtaaaggtaa aggtgtcatg atgacagctg aaacagcaga
     6121 agaaggcgtt gagtacatca tggacaaact gttaacaaag catgttatct aattgtaaag
     6181 gaaatgtggt gaatagaatg aatttagaac aatataaagg tgtatttatc tatgctcagc
     6241 aggttgacaa taagattgat gccattgctt tagaattact tggaaaagca aatgaccttg
     6301 ctgcagattt aggaacagac gtaacagcag ttttaatcgg ttctgacgta aaaggcttag
     6361 ttgatgaact tgctgaatac ggcgcagata aagttatcgt agttgatgac cctgaattaa
     6421 aagaatacag aacagagcca tatacacatg cactggcatc tgttatcaac gaatacaaac
     6481 cggacattct tctggttgga gcaacagcaa tcggtcgtga cttaggacct cgtgtttctg
     6541 caagagttgc aacaggtctt acagcagact gtactgttct tgaaattggt gaattcaaag
     6601 ctcgtggaga taaagaacct cgtcagggtc agttattaat gactcgtcct gcattcggtg
     6661 gtaacacaat cgctacaatc gcttgtccta accatcgtcc acagatggct acagttcgtc
     6721 ctggtgttat gcagaagaaa gagcctgttg caggtgcaaa ggcagaagtt attgagtaca
     6781 atccaggatt tactccaaat gacaaatatg ttgagattct tgacattgta aaatctgtta
     6841 cagaaacagt tgatatccag gctgctaaga ttcttgtatc tggcggacgt ggagttggct
     6901 ctgctgagaa ctttgcatta ttagacgatt tagcagaggc acttggcgga acagtttcct
     6961 gttctcgtgc agttgttgat aatggttgga aaccaaaaga tttgcaggtt ggccagactg
     7021 gtaagacagt tcgtcctaat gtttattttg caatcggtat ttccggagct atccagcacg
     7081 tagctggtat ggaagaatct gatatcatca tcgctattaa taaagatcca gatgcaccta
     7141 tctttgatgt agctgattac ggtattgttg gcgatgcatt aaagattgtt cctaagttaa
     7201 cagaggcaat caaagctcag gttaaataat ttcaaatcat atcagactca ttagattatg
     7261 tgagttactg attgaggatt gaaacttaga ttttttgtgg aagtctagta tatgcattct
     7321 cagatgtttt gtgtattgac gattcattat taaaagaagc atataggaga tttgtgctga
     7381 actctataaa atgtatttat gcagggaatc tttttgaaga ttccctgtta aagtgagata
     7441 gtaggactac agtttataac tgtggtcttt tttactttca ttcagttggc atagcccgct
     7501 acgccgtctt cattcaggaa aaattcccca caaattgtaa cgcacatctt gcaaaagcat
     7561 ttttcaaact cgctctagta tagcatccat tcagttgacg tagcccgcta cgccgccctc
     7621 attcaggtaa aatctcccac aaattgtaac gcacatcttg cagaaagcat ttttcaaaca
     7681 cgctctagta aaatacgtca tttttatttt atatataata aaaagtaaac ataataaaga
     7741 agtacttatc acaaaataaa cataatttgt caaaaatagt ggaaattaat tccaaatatg
     7801 ttataatact cttgcagcag ttaaccgaga tatgagagga ggcatttatg gcacaaatta
     7861 ttgcttcaac aaaagaaata tctaataaga gagagtcact gatagtattg agtaattcct
     7921 taaagaataa gatttcgctt ttagaaactt tggggaacag tcttaattct atgtgggaag
     7981 gcgctgcaaa agagaagtat gtaaagcaac ttaagacaga catttcaaag atgcggaact
     8041 tacttaagac aattttggaa tttatattga tactagagaa gattattgca atctataata
     8101 aagcagagaa gaagaatgag gcgacagcgg taagctagga gggggattta tggcagattt
     8161 aattaatgta actccagaga agttaaaggc gacagcaagt tctttccaac aggcaggaaa
     8221 ggacgttaag aaaactactt ctgatatgct tcagttagtg aggggaatta gtagttccat
     8281 ctggagtgga gaggcgagta gtatatatct tggtaagttt aatggattgg atgccgatat
     8341 cgccaagatg tgcaagatga tagaagaaga atcacagcat ttgacaacaa ttgcacagga
     8401 ataccagtta gcagaagaac agaataaaca ggttgcggca acattaaaga ataatgtaat
     8461 tgcttagatt gtatagacag atgaatagat tatgctgtca gttatgattt tttgtcatga
     8521 caaaagagaa ggagatttaa ttggaaagat atgtaatcag tgtgtggcgc ttatagataa
     8581 agagttttta cgtaatttta tcataagcga tgaagagtat catcaggtga atatagaggg
     8641 aatacagccg ccagatttac ttgtagtaga aatcacaggt atagaggatt tatgcagagc
     8701 gaaacgaata agggggattt tcccgagagg acgattgcta gttgtaagta ctaatcagat
     8761 ttcagcagag tcctatttaa ttccggaagt ttcaccagat atgcttttac tgaaaccata
     8821 tgtatatgcg aaagcttgta ggattatata ccgaagtctt acatggtgtt gtaaggataa
     8881 gtgtagaaag aaaaaacaag aagatatatt aaagattcgg acaggagggg agatttattg
     8941 ttttcattat gaagagattc agtatttaga agcaagagat aagaagatta tcttgcatgt
     9001 aaataagtat gagatttctt tttatagttc cttgcaaaag ttggagaaga gcctgccaga
     9061 ttattttatt cgttgccatc gtagttatat tgtgaatttt atgtttattc aaaaagcaga
     9121 tttgataaat ggtgaatttt atttgaataa aaagacagtt attccaattt ctcagaaata
     9181 taaggccaaa ttagcaaaaa tgttgtaaaa atataaggat tcaaggttcg atttaggttg
     9241 accgagttat acaacggtgg tagaatatac tcatgatatt tttttaacaa gagcagaagt
     9301 tgttaggagg agaagcatga gtttcattaa agaatatgca cagaaacttg ttacagcaga
     9361 agaagcggtt aaggtagtaa aatctcatga ttgggtagat tatggttgga caaccggtac
     9421 tccagttgca ttggatgcag cattagcagc cagagcagat gaattagaag atgttaagat
     9481 tcgtggtggt atcttattaa gagaaccaga gattttcaag gtaaataatg tagcagatca
     9541 ttttacatgg aattcctggc atatgggtgg tttggagaga aaggcaatca gtaaaggatt
     9601 tgcatactat tctccattaa aatattcaga acttccacgt tattacagag agaatatcaa
     9661 gcatttgaat gttgcgatgt tccaggttgc tccaatggat aaacatggat tctttaactt
     9721 tggaccaaat gcatcccata tgatggcagt ttgtgaagct gcagatgtaa ttatcgtaga
     9781 ggttaatgag aatatgcctc gctgtttggg tggatttgaa gaaggcattc atgtttctcg
     9841 cgtagattac atcgtagaag gcgagaatcc agctattggt gagttaggag ctggcgcacc
     9901 accaacagaa gtagacaaag ccgtagcaca gcttatcgta gaagagattc cagatggagc
     9961 atgtttacag cttggtatcg gtggaatgcc taatacagta ggttccatga ttgctgaatc
    10021 tgatttaaag gacttaggtg tacatacaga gatgtacgtt gatgcgtttg ttgacattgc
    10081 aaaggcagga aagattacag gcttaaagaa gaatatcgac agaggacgtc aggtatatgc
    10141 attcggtgca ggtactaaga agatgtatga ttatctggat gataacccag aatgtatgag
    10201 tgcaccagtt gattatacga atagcgctaa gacaatagca cagattgata actttatttc
    10261 tatcaataat gcagttgata ttgacttata tggtcaggtt aatgcagaga gtgcaggtat
    10321 aaaacagatt agtggtgcag gtggacagct tgatttcgtt cagggtgcat acttatctaa
    10381 gggtggtaag agttttatct gttgttcttc tacatttaca tccaaagatg gtgtaaagca
    10441 tacaagaatc agacctactt tagcagaagg atctacagta acagatactc gtcctaatac
    10501 acattatgtg gtaacagaat ttggtaaggt atgccttaaa ggtatgtcta catgggaaag
    10561 agcagaagca ttaattaata ttgctcatcc agatttcaga gatgaattaa ttaaagaagc
    10621 agaaaagatg catatttgga gaagaagtaa caaataataa tcacagcttt gaataagata
    10681 tcatatgtcg ggaaattagc taaaaagtaa aaatttaagg caagatatca agaaacctct
    10741 cacacaaaag ataaacaaac tgcaagtttg agatgatttt gtgtgggagg ttttttaatt
    10801 taataaatat ttacagctag aatgtttttc aaacacgctc tagaatattt acaagtaaat
    10861 aatattaaaa acagtagtgt aataattgtg gaagtatcaa tgtaatattt atttagaatc
    10921 taatatgttt ataaagttta ttctgaatgt aatattactt taaaacaaga ttatcaatat
    10981 ttcttatgat aatcgttgat ttaccagtta catctgtttg aacttcaaag ttagccagtt
    11041 tgttataagt ttccattgga atagatattt caattccgct atcagttacc atgacctgct
    11101 tttctaattt ctttacagta ctttcattgg tgacagtaaa gttatcatat tgtaagtcgt
    11161 actgttccat tttttcatca aattctgatt ttttttctgg actttttccg aaaagtttat
    11221 tacctatttc ttctatatcg aaagatttgt tatcaacgta ttctttttga agagcacttt
    11281 ttgtatccat ctttgttttt aaatcggcac catcgtattt attagaaata ttattaataa
    11341 cacgagtaag aatatttaac ttcttttttg gaggaatact ggtacggcag acaagaaagt
    11401 tttccgataa ataataagct ttctcaccat ttatctcata ctttttttcc aaaagcttta
    11461 tgtgataatc ggataaatta ataactacgg cctcaggtat tcttgaagtt gcagaaggaa
    11521 gcagagaatg tgttttgatg atgtctgtat taataacagg attatcagga gtctcggtga
    11581 cttcatgcgt atagctttcc ttgtaattca tttttaaaag ggcaagatag ataattcctt
    11641 ctgcctgaaa ggttacgaat aataaatcgg cagcgggtat atctaatccc tctcccatgg
    11701 caatatagag tttatttgca atggcctgac tggtttcaat gaaagaagtt tcatctgatt
    11761 catcccatgt ttctaagatg gaatagattg gagaatattc tgggtcaaat tcacagtttt
    11821 tggtatcatc gctggagaca attttataaa tatggtttcg aataaaatca tgtaaatctg
    11881 gccctggatc taagagagta ttagaaagaa tacattctcc gcgattggtg tctaaaatat
    11941 gcaaaatagc ttttcttata acaatatcat cttttgctat catgaggcag ctcctttatt
    12001 ttttatttga ttaaatagta taccacttta ggagtaaaga agctatgaga tttttaattt
    12061 ttatatacgg aaaaagcagg atgaaacgca cacagcttgt cagcgataag agggcagagt
    12121 gtcatatatt attacctaaa gatgatttct ctttggaaag gacagtattt ttacagttta
    12181 aaaatatatc tggagaatgg tttatcaagg aaacagactg ttgtcatttg aaaacagaag
    12241 aattttttca gatgggaaaa cggaaaagtg atgaaggaat attttacaag ttgtcaagag
    12301 ggagaaagaa tgaactatcg gtaggtggga aggatcttta tatacagctt atacgatata
    12361 ggaatgactg gagcatatat aagaaatata aacttagaga ttgtcggata ataaaagaga
    12421 aaaatatatt cataatgatg gagaaagcca ttaatagaaa aaatagtatg ggtatttcat
    12481 atgagtatgg caaatggttc atagagaaat gtgggaatat agaaatatat attaatgaaa
    12541 ttttgttaga gaaaaagcag caattagagt ttggtgatgt tatatgtatt ggaactatat
    12601 atttgttatt ttttgagaac tatatagcag tagaagctgg tgagagaaat atagtatcag
    12661 attatttgga agaagtagta ttagaaaatg agataaaggg acaagaggat gttaggaaga
    12721 aggaaaaaag agagataact tttcacaggg caccgagagt aatggaagaa ttaaaaaaag
    12781 tatcattaaa agttgatgca ccgccccaag tggatgtaca ggagaaaaaa tctatattta
    12841 tggatatagg tactatcatg aatctgatgt ttccaatgtt aggaatgaac ttatttttaa
    12901 tttatggaat gaaatcagag cagaatcagg caggaatata tgtatattct ggactgttta
    12961 tggcagtgat gtcagcggta tgttctattt tatggcttat gatttcgaga aagtatgaaa
    13021 aaagagaaca gcagaagaaa gttaataaag agcgactggc ttataggaga tatttgaata
    13081 aaaaaagtga atatatcaaa gtgcagtatg aacgggtata taaggtttta caaagtagat
    13141 atttacgggc agatacttat ttagatagcc cattattaga tatgtattta tggaatcgaa
    13201 atctatatca taaagatttt ttaatgtaca gaattggtat aggtgacgtt gagtttccta
    13261 tgaaaataga atttcctgag gaagtgtttg gcgatgagga aaatattcta tggcgggaag
    13321 caaaaaagat aaaggaacat tatgagattc tacatcagat tcctgtgtta ctcgacatgg
    13381 gaaggtatag tcagattgga atcataacaa aagatacgat agcaggaatg gaacttgtaa
    13441 gaagtattat tttacagatt gcgttgtgta attgttacac ggaagtaaag ataggatgta
    13501 tttataacaa aaataaggtt attcaatcgc agcaatggga tttttgcagg tggcttccgc
    13561 atatatggga tgccaataga caaaagcgat ttattgcagg gaatgaggta gaagcgaggc
    13621 ggttattcta tgatttgttg cagattttta aagaaagaga agaagtatct atatccggta
    13681 aggcagaaaa aattttgcca cattatattt tgtttgttgc agaagaacaa tttttggaag
    13741 gagaaatgtt ttctaaatat atcttagata gaggaagaga atatggattg acagttgtat
    13801 ggctggactc gatgagaaaa aaattgccga atacatgtaa aatggtattg gaaataaatg
    13861 ggggatttac tgggcggtat gagatagaaa ggcacagtca gaagaaagag aaaataaatt
    13921 ttgattatac ggaaaaaaat attgcggaga aattaataag gagtatttca ggaataaaag
    13981 tgatggaaat tgaagaaaag gctggtatac cagaagttgt tgatttttta ggaatgtatg
    14041 atgtgcacac gatagaagaa ttacatataa aacagcgatg ggaaaagaat agaatttttg
    14101 aaagtgcaaa ggttttaata ggtaaaaaag cgggagatga acctttttat ttagatatac
    14161 atgagcgata tcatggaccg catggtttat tggctggaac gacaggttca gggaaaagtg
    14221 aagtacttca gacatttatt ttatccatgg cagtgaattt tagtccggaa gcggtgtgct
    14281 ttttgttaat tgattataaa ggagagggga tgtcagcgct attttctgaa ttaccacata
    14341 tttcaggaaa aatatcgaat ttatcagatg ggcaggcata tagagcaatg gtatcaataa
    14401 aaagtgaaaa taaacgaagg caaagaatat ttaaagaatg taaggtaaat aacattaatg
    14461 attatacaag gttgtttaat tcgggaagtg taaacgaacc aattcctcat ttactgatta
    14521 ttattgatga gtttgccgaa ttaaaaaagg cggagccgga atttatgcag gaattaatta
    14581 gtgttgctca agtagggagg agcttaggtg ttcatttgct gctggcaact caaaaaccag
    14641 gaggtgttgt tgacgataag atatggagta attcaagatt ccgaatttgt cttaaagtgc
    14701 aggaaaggga agatagcatg gatatgcttc ataacatgga tgcctgccag attacacaaa
    14761 caggaagagg atacttgcag gtagggaata atgaagtata tgagttgttc caagcaggct
    14821 ggagcggggc tttatttcag caagaggata cggaagtggc agcatgtctg gttcaaacag
    14881 atggaaccat atataaaaga agaaagaatg ctgagaagaa cagagagaaa aagataacac
    14941 aattgcaggc aatcaaacag tatattatac gttttgcaaa agaaaaggaa tatcaagagg
    15001 gaagaaaatt atggctggag ccattgtcga agtatatata tttagatgag attcacaaag
    15061 aaatgaataa aaagttaaaa gagaaaaggc aaagagttga catgaataag aacttggaag
    15121 tatgtgtcgg tatttttgat gatcccgaaa atcaggaaca gtctatattt tccttaaatc
    15181 ttatggaaag cggacacata gctatctgtg gcagaagtgc ttctggtaaa agtacctttt
    15241 ttcaaacatt tctattttca ttattaaaag agagtacagc agaagaagta tgtttatatc
    15301 tgttggattt caatggaagt ggtatggaca tatatgattt aatgccccag gtaaaacagg
    15361 ttataaaaga ggaagaagag gataaagtag aagaattatt tgaaaatata aaaaaagaaa
    15421 tga
//
