LOCUS       c00052_gnlPro..        14482 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CLDKADLJ_52.
ACCESSION   c00052_gnlPro..
VERSION     c00052_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 19:36:28
            Original ID  :: gnl|Prokka|CLDKADLJ_52
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14482
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14482
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3077:8050]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3078..8050
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14482
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14482
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             2..91
                     /locus_tag="ctg52_1"
                     /transl_table=11
                     /translation="ISKPIDLNIHNADNLDEIMEQLQPYLVTE"
     CDS             complement(351..1535)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:Thiamine biosynthesis protein (Score: 226.6;
                     E-value: 6.8e-70)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_2"
                     /sec_met_domain="ThiI (E-value: 1.5e-70, bitscore: 226.6,
                     seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFKAFLIKYAEIGIKGNNRRFFEDALVRQMKYALKPVGNFSIRK
                     ESGRIFVHANEEYDFDEAVESLSHVFGIAGICPIVVEEDKDFEKIAEVVEKYVDEDYAD
                     KHFSFKVHVRRADKKYPIPSMEAAARLGERLLEKFEDLSVDVHNPDVMLTVEIRDKVYI
                     YSREIPGPGGMPVGTNGRAMLLLSGGIDSPVAGYMISKRGVSIDATYFHAPPYTSERAK
                     QKVVDLAKEIAKYTGPITLHVVNFTDIQMAIYEKCPHDELTIIMRRYMMKIAEHFANQD
                     NCLSLVTGESIGQVASQTMHSLYVTNEVCQMPVFRPCIGLDKNEIVKVAEKIGTYETSI
                     LPYEDCCTIFVAKHPVTKPRLDVIKRSERNLDDCIDELMKTAIETTEEIKINAH"
     CDS             complement(1632..2780)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_3"
                     /sec_met_domain="Aminotran_5 (E-value: 2.2e-78, bitscore:
                     253.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEIYFDNGATTRALPQVREIMDEVLEKEYGNPSSMHMKGFDAEK
                     YVNHAKEIIAKSLKVDPKEIYFTSGGTEANNLALIGTAFANKRERKHIITSCIEHASVY
                     NPLSFLEDEGFEVTYLPVDEHGIVDLEVLKKALRKDTLMVSIMCVNNEIGAIEPVEEIG
                     KIVKSFDPKILFHTDCIQAYGKLNCYPKKWKADMISVSGHKIHGPKGIGFIYIKNGTKI
                     KPIIWGGNQQKGMRSGTENVPGIAGLGKAAELIYENHEEKIAHIREIKDHFIKRVMEEI
                     PDVKDNSGDAPHVASISFLGVRSEVLLHALEEREIYVSAGSACSSNKPEVSGTLKGIGL
                     TKEYYESTLRFSFSIFNTVEEADICVEALKELLPMLRRFTRR"
     CDS             complement(2817..3002)
                     /locus_tag="ctg52_4"
                     /transl_table=11
                     /translation="MRLSILLERLSLQLEGSILFHFHLFIRKIHFTSLSFYVMFIYDYA
                     IFYGCFLSVENGTKKQ"
     CDS             complement(3078..4490)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_5"
                     /sec_met_domain="HMGL-like (E-value: 3.1e-43, bitscore:
                     138.0, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 4.3e-59, bitscore:
                     189.5, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEIKKKPVKIVETVLRDAHQSLIATRMTTEEMLPIVDKMDQVGY
                     HAVECWGGATFDACLRFLKEDPWERLRKLRDGFKNTKLQMLFRGQNILGYKPYPDDVVE
                     YFVQKSIANGIDVIRIFDCLNDLRNLQTAVNATKKEGGHAQVALSYTIGDAYTLDYWKN
                     TAKNIEEMGADSLCIKDMAGLLVPNEATRLVTALKQATDIPIELHTHYTSGVGGMTYLK
                     AVEAGVDIIDTAMSPFAMGTSQPATEVMAETFRDTEFDTGFDQKLLGEIADYFRPIREK
                     YLANGLMSPKVLGVNIKTLMYQVPGGMLSNLVSQLEQQGASDKFYEVLEEVPKVRKDFG
                     EPPLVTPSSQIVGTQAVLNVLTGERYKMITNESKALLRGEYGQTVKPMNKEVQKKAIGD
                     EKPITCRPADLLEPELSKIEAEMSQWKEQDEDVLTYALFPQVATEFFKYRAAQENKIDP
                     AKADVKNGAYPV"
     CDS             complement(4648..5772)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_6"
                     /sec_met_domain="OAD_beta (E-value: 1.3e-157, bitscore:
                     514.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVVETMTNLAAQTGFAFLKPGNFIMILVALVFLYLAIAKGYEP
                     LLLVPISFGMLLVNLYPSIMEEGGLLHYFYLLDEWSILPSLIFLGVGALTDFGPLIANP
                     ASFLLGAAAQFGIYSAYFLAMLMGFNGKAAAAISIIGGADGPTSIFLAGKLGQTDLMGP
                     IAVAAYSYMSLVPIIQPPIMKLLTTEKERQIKMEQLRTVTKTEKIMFPIVVTVVVCLIL
                     PTTAPLVGMLMLGNLFRESGVVKQLSETASNALMYIVVIILGTSVGATTSAEAFLNVST
                     IKIVVLGLVAFAVGTAAGVLFGKLMCKVTGGKVNPLIGSAGVSAVPMAARVSQKVGAEA
                     DPSNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             complement(5806..6174)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.6; E-value:
                     4.3e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_7"
                     /sec_met_domain="Biotin_lipoyl (E-value: 9.7e-22, bitscore:
                     66.6, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNYRITVNGVAYDVAVEELGAGEASAAPVSTPAAVPAPAKKAAP
                     KTSGSAGAVKITAPMPGKIVAVKAQAGASVKKGDAVLVLEAMKMENEICAAQDGVIASV
                     EVAVGDMVEGGDVLATMN"
     CDS             complement(6269..6613)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_8"
                     /sec_met_domain="OAD_gamma (E-value: 6.3e-28, bitscore:
                     87.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVFEQALLNTLMGMGTVFAVLIFISLLISLFVYIPSIERALKNR
                     SSKKEKKAAQEERPAPKRPILEEVVEEEELVDDGELVAVITAAIMAANGGAAVSTDKLV
                     VRSIKRVKRR"
     CDS             complement(6626..8050)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_9"
                     /sec_met_domain="CT_Vparvula (E-value: 1e-137, bitscore:
                     449.6, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNSKMNARERIDYLFDDHSFVEVGGYVSARNTDYNLGAKKVEGD
                     GVITGYGVINDRMVYVYSQDASALGGSVGEMHAKKIASLYDLAMKTGAPIIGMLDCAGL
                     RLQEATDALHAFGTIFNKQAQASGMIPQISAVFGMCGGGSAVMSAMSDFTLMEKENGSL
                     FINSPNALAGNEESRQNTAGAQFQSEQAGNVDFVCETEEALLDQLRILVDVLPSDYEAE
                     DVYFDNDDDLNRVIPELNDAAYDAAYILKSISDNNMYIETKAAYAKEMVTAFIRLNGET
                     VGAVANQPVDGEAVLTRNGLEKAERFIKFCDAFSIPLLTVTNVTGLRANAHEERKQALA
                     LAKFTTTLAQVSVPRINLIAGEAYGTAAEVMNSKAIGADFVLAWPRASVGMMDAEQAVR
                     IMYAEEINTDKNKTALIAEKTAEYAEGQSSALAAAKRGYIDDIIEPDATRKRLIAAYEM
                     LYGKKVTPVTKKHTAV"
     CDS             8773..9414
                     /locus_tag="ctg52_10"
                     /transl_table=11
                     /translation="MENRKIQFRSKACNLHLSAYPGHFATKHSHVNYFLDMTTLKVRQS
                     NAEEAARALVPLYKHNTVVDTIVCLDGTEVIGAFLAEKLTESGFFSYNQHKSIYIVTPE
                     IDSDGQMFFRKNIQPMIKDRNIIILMASVTTGITINRSWECIEYYGGKLQGISAIFSTL
                     SEYGNLPVNALFTPNDIPTYHTYDKHDCPYCKSGQKIDALVNGHGYSELL"
     CDS             complement(9548..10561)
                     /locus_tag="ctg52_11"
                     /transl_table=11
                     /translation="MQKIPECRSMNFSIYEGMLNRYKDSEDIRKSYESRGLNGLEVIRA
                     GEPDEGKILPDMVNGVHLYFHIFWMDWWKGNYERLDQEFDSREQWLEYFGGMSRESYLN
                     SLRDDLAYAEQVGAKYVVFHVSEVTLRESYIYKYRYTDKEVIDASLEVINTLLDEKEYP
                     FDFLVENLWWSGLTLKNVRLTRRLIEGMHTQKKGIMLDTGHYMNTTTQLKTPEDAVAYL
                     NKMIDKYEKAQMLHWFKGMHLQLSLGGDYVRKQRKEWREHPIDFDKIPFYELFRLAYDH
                     ACHIDLHQPFIGEGVREFVERVAPKYITLEYQQNSREEYEQFVETQSKILKWITIH"
     CDS             complement(10698..11672)
                     /locus_tag="ctg52_12"
                     /transl_table=11
                     /translation="MADWKSSQEFLKEFYASPIVNEDTISAKIKRIFLPKSRKASALKE
                     LAGDLSGEGRAGDVILDNDMFEMDTEIWKKQEKRRLSVRTRVSLFLLLVAIPLTIAVGF
                     YVMDVAAVGTVFEKIFGPRKYYFISLVIIIYSLLPFFMVFEGRKPQVRELVVLATMVAL
                     ATAGRAAFFMIPSFKPIIAIVIISAIAFGGEAGFLVGAMTMVVSNFLFGQGPWTPWQMF
                     AMGFIGFLSGILYRIGLLPTKRLSLCIYGFLVTVFIYGGIMNPAALFMSVYDFTWEGLL
                     AIYISGIPVDLVHASSTFIFLWIGAKPLLEKLQRIKIKYDLMR"
     CDS             complement(11676..13457)
                     /locus_tag="ctg52_13"
                     /transl_table=11
                     /translation="VTANGLSEKKNSILEINDLCFAYPEEKKRALNHVSLHVEDGEFLV
                     LCGKSGCGKSTLLTHLKTPLTPHGKRKGEILFQGVPIGEMSNREQSQRIGYVLQNPDNQ
                     IVTDKVWHELAFGLESLGYSNADIRIRVAEMASYFGIQDWFYKNVSELSGGQKQLLNLA
                     SIMAMHPDMLILDEPTSQLDPIAASDFLETVKKINRDLGTTIILTEHRLEEVFPSADRV
                     VVMDEGQILCVGTPPEIGEELKKRNHEMFLAMPVPMQVYAKVESEQPCPITVRDGRKWL
                     DIVCKKKGISPANASSSYRKESDSQKGKSSFAKITEKFTEKKEDIILACDDLWFRYDKE
                     LPDVVKGLSFFLKRGEFFALLGGNGTGKSTTLSLLSRLRKPYRGKVLLEGKDIRRYSDK
                     ELFRNFLGVLPQNPQSLFVKKSVELELFEMVGGVKEKKDEEYQLAMDKKDAVEGIIKVT
                     HLEELLHRHPYDLSGGEQQRLALAKILLLRPKLLLMDEPTKGLDSYFKKEFAGILALLK
                     EQGVTVFMISHDIEFCASYADRCGLFFDGNIVACGTPGEFFAGNNFYTTAANRMARRYF
                     PMAVTGEDVVKCLKKGV"
     CDS             complement(13499..14440)
                     /locus_tag="ctg52_14"
                     /transl_table=11
                     /translation="MKDTFSTYHPVLNMLYFCGTIGVTMFVVHPVILAISFICAVAYSV
                     VLKGWKKTVKFNLLFSLPMMIIVALINPMFNHYGVTIIGYLHNGNPFTLESCVYGLVMA
                     VMLVCTLVWFSCYTVVMTSDKFIYLFGRIIPALSLVLSMCLRFVPKFIKEASVISDGQK
                     CVGRSVENGSLIKRAKHGITIFSILVTWSLENAIETSDSMKCRGYGEKGRTAFSLYHFD
                     KRDFLCLIFMIITFGAAMWGFSKGYAFCSYNPRIVVKGVPFTAGSLLVFAAFLLFSIMP
                     AAMEILDRRMWKARRGQVESAAPAGYRLWEVE"
ORIGIN
        1 tatttctaaa cctatcgatt taaatatcca taacgctgat aatcttgatg agattatgga
       61 acagttacag ccatacttag taactgaata attacataag agcgggtttt ctggtatacg
      121 gatatattat atataacctg tgatgtattt atgaaatcaa ccgaggaaat attactttcc
      181 tcggttcttt ctttacagat aaatttttct tatatgaatc ttcagataaa acaaatattt
      241 ttagtgatat ttcttcttcc caccttttaa aaaggcactt atctgcaagc attataaaca
      301 ttatcaaaat acttatgtct gccttgaaaa tgctttcatc cattaatact ttagtgagcg
      361 ttaatcttaa tttcttctgt tgtttcaatc gctgtcttca tcagctcgtc aatacaatca
      421 tcaagatttc tctcagaacg cttaattaca tctaatcttg gctttgttac cggatgtttt
      481 gccacaaaaa tagtacagca gtcttcgtat ggtaaaatag atgtctcata tgttccaatc
      541 ttttctgcaa cttttacgat ttcattttta tcaagtccga tacaaggacg gaatactggc
      601 atctggcaca cttcatttgt tacataaaga ctgtgcattg tctgactggc aacctgtccg
      661 atactctcac ctgtaacgag ggaaagacaa ttatcctgat ttgcgaaatg ctctgcaatc
      721 ttcatcatgt aacgacgcat aatgattgtc aattcatcat gaggacattt ctcataaatt
      781 gccatctgaa tatctgtaaa gtttacaaca tgtaatgtaa taggtcctgt atattttgca
      841 atctcttttg caagatctac tactttctgt ttcgctctct cacttgtata aggaggtgca
      901 tggaagtaag ttgcgtcaat gcttacaccc cgcttggaaa tcatgtaacc agctaccggg
      961 ctgtcgatac caccggaaag aagaagcatt gctcttccgt ttgtaccaac cggcattcca
     1021 cccggtcccg gaatctctct ggaataaatg taaaccttat cacgaatctc gactgtaagc
     1081 ataacatctg gattatgcac gtcaacactt aagtcctcaa acttctctaa taatctctct
     1141 ccaagacggg cagctgcttc catagacgga attggatact tcttgtctgc tcttcttaca
     1201 tgtactttga aagaaaaatg cttatctgca taatcttcat ctacatattt ttctacgact
     1261 tccgcaatct tttcaaaatc tttatcttct tctactacaa ttggacaaat acctgcaata
     1321 ccgaatacat ggcttaagct ttccaccgcc tcatcaaaat catactcttc attggcatgt
     1381 acaaaaatac gtccagattc ctttctgata gaaaagtttc ctactggttt taatgcatat
     1441 ttcatctgac ggacaagggc atcttcaaag aaacggcgat tgtttccctt gattccaatt
     1501 tctgcatatt taatcaaaaa tgctttgaat tccataaata tctccttttt tatatgatgt
     1561 actctcgtag tctttcttgt cacaaaatca agctcaaaaa gattccgaga gtacattatg
     1621 ttctaattgt tttatcgtct tgtaaatctc cgaagcatcg gcaacagttc ttttaacgct
     1681 tccacacaaa tatctgcttc ttctaccgta ttaaaaatag agaatgaaaa acgaagcgtc
     1741 gattcatagt attcctttgt aagaccaatg cccttcaaag taccactgac ttccggttta
     1801 ttagatgaac aggcagaacc tgctgataca taaatctcac gttcttctaa tgcgtgaaga
     1861 agcacttcac ttcttactcc taaaaagctg atactcgcca catgcggagc atctccggaa
     1921 ttatccttca catctggaat ctcttccatc actcttttta taaaatgatc ttttatctct
     1981 ctgatatgtg cgatcttttc ctcatgattc tcataaatca actctgccgc cttaccaagc
     2041 cctgcaattc ccggtacatt ttctgttccg gaacgcattc ccttctgttg atttccaccc
     2101 cagatgattg gctttatctt tgttccattc ttaatataaa taaatccgat tccctttggg
     2161 ccgtgaatct tatgcccact tacagaaatc atatctgctt tccatttctt agggtaacaa
     2221 ttcaacttac catatgcctg aatacaatcg gtatggaata aaatctttgg atcaaaagac
     2281 tttacaatct ttccaatctc ctcaaccggt tcgatggcac caatctcatt attcacgcac
     2341 ataatagaaa ccatcaatgt atctttacga agcgccttct ttaatacctc taaatctacg
     2401 attccatgtt catcgacagg aagataggtc acttcaaatc cctcatcttc taaaaaagat
     2461 aatggattat atacagaagc atgttcaata cagcttgtaa taatgtgctt tctctctctt
     2521 ttatttgcaa atgcagtacc gatcaatgca agattattcg cctctgtacc accagaagta
     2581 aaataaatct cctttggatc aactttcagg ctctttgcaa taatctcttt cgcatgattg
     2641 acatacttct ctgcatcaaa tcctttcata tgcatagaag atggattgcc gtactccttc
     2701 tcaagtactt catccataat ctcacgcacc tgcggcagcg cccttgtggt cgcgccattg
     2761 tcaaaataaa tctctgacat tctcgtttac aactccttca aaaaatatat tatgtcttat
     2821 tgtttttttg ttccattctc tacactcaaa aaacagccat aaaaaatggc ataatcgtat
     2881 ataaacataa cataaaatga gagagaagta aaatggattt tgcggataaa cagatgaaaa
     2941 tgaaaaagga tactcccctc aagctgtaaa gatagtcgtt cgagcaaaat gctcagtcgc
     3001 attttcactc actccgacat tacatcttga ggggagtatc ctttttcatt ttcgtctgtt
     3061 tttaatctaa atcaatccta caccggatat gctccattct ttacatcggc ttttgcagga
     3121 tcaatcttat tctcctgtgc cgctctgtat ttaaagaatt cggttgctac ctgtgggaac
     3181 aatgcgtatg taagcacatc ttcgtcctgt tctttccact ggctcatctc tgcctcaatc
     3241 ttagataatt ccggttcaag aaggtcggct ggacgacagg taattggctt ttcatcgcca
     3301 attgcctttt tctgtacttc tttattcatt ggttttacgg tctgaccgta ttctccacga
     3361 agaagggctt ttgactcgtt tgtaatcatt ttataacgct ctccggtaag tacatttaat
     3421 acagcctgtg ttccgacaat ctgactggac ggtgtaacta atggtggttc accgaaatct
     3481 ttacgtacct ttggcacttc ctctaatacc tcatagaact tatcagatgc gccctgctgc
     3541 tctaactgag atacgaggtt ggaaagcatt cctcccggta cctgatacat taacgtcttg
     3601 atatttacgc caagtacctt tggactcatt aaaccatttg ccagatattt ctcacgtatt
     3661 gggcggaaat agtctgcaat ctcgcctaaa agcttctggt caaatcctgt atcaaattct
     3721 gtatcgcgga atgtttcagc cataacttct gttgccggct ggcttgttcc cattgcaaat
     3781 ggagacatgg ctgtatcaat gatatcgact cctgcttcta ctgcttttaa gtaagtcatt
     3841 ccaccgacac cacttgtata gtgtgtatga agttcgatag gaatgtctgt tgcctgcttt
     3901 aatgcagtta caaggcgagt tgcttcattc ggcactaaaa gacctgccat atctttgata
     3961 caaagggaat ctgcacccat ttcttcgata tttttcgctg tatttttcca gtaatctaat
     4021 gtataggcat caccaattgt ataagaaagg gcaacctgcg catgtcctcc ctctttcttt
     4081 gttgcattta ccgctgtctg taagtttcta aggtcattta aacagtcaaa gatacgaatg
     4141 acatcaattc cgtttgcgat agacttctgt acgaaatatt ctacaacatc gtctggatat
     4201 ggcttatatc ctaagatgtt ctgtccacgg aataacatct gtaactttgt attcttaaag
     4261 ccatctctta atttacgaag tctctcccat gggtcttcct ttaagaaacg caggcaggca
     4321 tcaaatgttg cacctcccca gcattctact gcatgataac caacctgatc catcttatct
     4381 acgattggca gcatctcctc tgttgtcatt cttgtagcaa tcagagactg atgtgcgtca
     4441 cggagaacgg tttctactat tttaaccggt tttttcttaa tttcggccat aatatctcct
     4501 tttatttcaa atcacgtaac tatttgcgct tacaactgtt attatctaaa attcaacttg
     4561 taaactattt ataaatatcc cctgtaacat tttttacaga ttatagccct ataaataatg
     4621 aattttaaat aatcaaataa ttctaaatta tactccaaaa attgccataa atgttccggc
     4681 tgctaccgct gtaccgataa ctccggcaac gtttggtccc atcgcatgca tcagtaagaa
     4741 gtttgatgga tctgcttccg caccaacttt ctgggataca cgggctgcca taggaacggc
     4801 agatacccca gcagaaccaa ttaatggatt taccttacca cctgtaacct tacacataag
     4861 tttaccaaac aggacacctg ctgcagtacc aacagcaaaa gctacaagac ctaatactac
     4921 aatcttgatt gtgctgacat ttaagaatgc ctctgcactt gttgtcgcac caacggatgt
     4981 accaagaata ataactacga tgtacataag agcgttagac gctgtctctg aaagctgttt
     5041 tactacgccg gactctctaa aaaggttacc gagcatcagc ataccaacta atggtgctgt
     5101 tgtaggaaga atcagacata caacaactgt tacaacgata gggaacataa ttttctctgt
     5161 ttttgtaacg gttcttaact gttccatctt aatctgacgt tccttttctg tagtaaggag
     5221 cttcatgatc ggtggctgaa taattggtac aagtgacata taagaatatg ccgctaccgc
     5281 aattggtccc attaagtctg tctgcccaag ctttccggca aggaaaatag aagtaggacc
     5341 atcggctcca ccaataatgg aaattgctgc tgctgccttt ccgttaaatc ccataagcat
     5401 tgcaaggaaa tacgcgctgt aaataccaaa ctgcgccgca gctcctagca agaaacttgc
     5461 tggattggca atcagcggac cgaagtctgt tagtgctcca acgcctaaga aaatcagtga
     5521 agggagaata ctccattcat ctaataagta aaaataatgt aataatccgc cttcttccat
     5581 aatggacgga tataagttaa ctagcagcat accaaaagaa atcggcacta acaaaagtgg
     5641 ctcatatcct ttggcgatgg ccagatataa gaagactaaa gcaaccagta tcataatgaa
     5701 gttacctggc tttaagaatg caaatccggt ctgtgctgcg agattcgtca ttgtctctac
     5761 aacataactc ataaatcttc ctccgtttta ttttgcaaat atgctctagt tcattgtagc
     5821 cagtacatct ccgccttcta ccatatctcc aactgctact tccacacttg cgataacacc
     5881 atcctgtgct gcacagattt cattctccat cttcatagcc tctaatacaa gaacagcgtc
     5941 gcccttcttt acagaagcac ctgcctgtgc ctttactgct acgatcttac ctggcattgg
     6001 tgctgtaatc tttacggcac cggcacttcc ggaagtcttt ggggcagctt tcttagctgg
     6061 agccggaacg gctgctggtg tacttaccgg cgctgcactt gcttctcctg cacctaattc
     6121 ttctactgct acatcataag caacaccatt aactgtaatt ctataatttt tcattgtaaa
     6181 tcctcctgaa tgattttatg tacttctaaa atctttctat agctaacttt tcaaaacttt
     6241 ataaaaagat tccaagaata catttttgct atcttctctt cactctcttg attgaacgaa
     6301 cgaccaactt atctgtactg actgctgctc ctccattcgc tgccatgatt gccgctgtga
     6361 ttactgcgac aagttcacca tcatccacaa gttcctcttc ttccacaact tcttcaagaa
     6421 tcggacgctt tggagccggt ctttcttcct gcgcagcctt tttctctttc ttagaagaac
     6481 gattctttaa cgctctttca atagatggga tatatacaaa aagagaaatc agtaaagaaa
     6541 tgaaaatcag tactgcaaat acagttccca tacccatcaa agtatttaat aaggcttgtt
     6601 caaatacgtt catactctca cctcactata ctgccgtatg cttctttgtc actggagtta
     6661 ctttctttcc gtaaagcatt tcataagcag cgataagacg ctttcttgtt gcgtccggct
     6721 cgatgatgtc atctatatat cctctctttg cagctgctaa tgcactgctc tgtccttctg
     6781 catattccgc agttttctct gcaataagtg ctgtcttatt cttatctgta ttgatttcct
     6841 ctgcatacat gatacgaact gcctgttctg catccatcat tcctacagat gcccgtggcc
     6901 atgccagaac aaagtcagct ccgatagctt tagaattcat tacttccgct gcagttccat
     6961 aagcctcgcc tgcaatgaga ttaatacgag gtacactaac ctgtgcaagt gttgtcgtaa
     7021 acttcgctaa tgcgagagcc tgctttctct cttcatgtgc gttggcacga agtcctgtca
     7081 cgttcgttac agtaagaaga ggaatcgaaa atgcatcaca gaacttaata aatctttctg
     7141 ctttttcaag accatttctt gttaaaacgg cctcaccatc tactggctgg tttgcaaccg
     7201 cacctactgt ctctccattc agacggataa atgcagttac catctctttg gcataggctg
     7261 cctttgtctc tatgtacata ttgttgtcag aaatagattt taaaatgtaa gcggcatcat
     7321 atgcggcatc atttaactca ggaataaccc tatttaaatc atcatcgtta tcaaagtaaa
     7381 catcttctgc ttcataatca gaaggaagta catcaacgag aatacgaagc tggtcaagaa
     7441 gtgcttcttc tgtctcacat acaaaatcta cgttaccagc ctgctcagac tggaactgtg
     7501 ctcctgccgt attctgacgg gattcttcat tccccgctaa tgcattcgga ctgttgataa
     7561 agagactgcc gttctccttc tccatcaatg taaaatcaga catagcggac attacggcac
     7621 ttcctcctcc acacattcca aatactgcag aaatctgtgg aatcattcca gatgcctgtg
     7681 cctgcttatt aaaaatcgtt ccaaaagcgt gaagggcatc tgtcgcttcc tgtaatctaa
     7741 gtcctgcaca atccagcatt ccaatgattg gcgcgcctgt tttcatcgcc agatcataaa
     7801 gggaagcaat tttcttcgca tgcatctcac ctacggaacc tccaagtgcg gaagcatcct
     7861 gactgtaaac ataaaccatg cggtcattaa taactccgta tccagtgata acaccatcac
     7921 cttctacttt ctttgcaccg agattataat cggtattacg agcggaaaca tatccaccaa
     7981 cttccacaaa actgtggtca tcaaacagat aatcaatgcg ctctctggca ttcatttttg
     8041 aattacccat attctttcct ccataaaaat gctatattgt ataccttgtt gctctttcat
     8101 tctatgtaat aataacaaat tattatcatg ttagcaacca ttttctgtta gttatttaac
     8161 atttatttta ttttgcccat tccactaaac aaaatgaaca ttctgcctat ttgcaaattt
     8221 tttaacaatt ctttcaattt tctttctgaa tctcctgttt ttttcaggaa tgcttgtgta
     8281 tttttcctgt ttttctctat tttatcttta aaattctatt tttgttttat atgtccattt
     8341 ttatttcgtt ataattttaa cgtattttga cattcaatta ctagttggtt tttctatttt
     8401 ttcgtcattt tatacaaaac attttcattt catcaaatat cttccgtttt tcttcataat
     8461 ttcactctta tttccatcat tcttcttctc tcgcttatat tctcctcctg tcttttttaa
     8521 atcaaagata tagtatccaa aatcaatttt gggctatttt tgtcaaactt ttttcacaaa
     8581 ctaatagcgc tccctttcgt tttatacaac tgtatatgca taccacgaag tattttcaaa
     8641 aaatcagaaa gaaattataa actgtcaaga aaagcctgta attttgcaca aatactcctt
     8701 tattttttca cacaaaaaag gtataataaa caaaataaac aattctttca caataaagga
     8761 ggaggacatc ttatggaaaa ccgcaaaatt caatttcgtt caaaagcctg taatctacat
     8821 ctttctgcct atccgggaca tttcgcaaca aagcattctc atgtcaacta ctttttagat
     8881 atgacaacat taaaagtacg tcagtctaat gcagaagaag ctgcaagagc gttagttcca
     8941 ctttataaac ataataccgt cgtcgatacc atcgtatgtc ttgacggaac agaagtaatc
     9001 ggtgcatttt tagcagaaaa gcttacagag agcggattct tctcttacaa ccagcataaa
     9061 tctatctata ttgttactcc agaaatagat tcagatggtc agatgttctt ccgcaaaaac
     9121 atccagccaa tgattaaaga tagaaatatc attattttaa tggcatctgt cacaactgga
     9181 atcacaatca accgaagctg ggaatgtatc gagtactatg gtggcaaact gcagggaatt
     9241 tcagcaatat ttagtacgct ttctgaatat ggtaatcttc ctgttaatgc gctgtttact
     9301 ccaaatgata ttcctactta ccatacatat gataagcatg actgcccata ttgtaagagt
     9361 ggtcagaaaa tcgatgcttt ggtaaacgga catggatatt ccgaattact ataactacta
     9421 atttgtagat ttcgtataga cgaaaaagag aaaccatacc atatcccaga tgcggatgag
     9481 cattttaaac acaacgacta cagagcagat gggatatggt atggtttctt ttttcgtctg
     9541 ttttctctta atgaatcgta atccatttca aaattttact ttgggtttct acgaattgtt
     9601 catattcttc ccggctgttt tgctgatatt ccagcgtgat atactttggt gctacgcgct
     9661 ctacaaattc ccggacacct tctccgataa aaggctgatg cagatcaata tgacaggcat
     9721 ggtcatatgc aaggcgaaat agttcataaa atggaatctt atcaaagtct atcggatgtt
     9781 ctctccattc ttttcgctgc tttcttacat aatcccctcc cagtgacaac tgcaggtgca
     9841 ttcctttgaa ccagtggagc atctgtgctt tttcgtattt gtctatcatt ttattcagat
     9901 atgctacggc atcttccgga gtctttagct gtgttgttgt attcatataa tgcccggtat
     9961 cgagcatgat tccctttttt tgtgtatgca ttccttctat aagccggcgg gtaaggcgga
    10021 catttttcaa ggtaagcccg ctccaccaga gattctctac aagaaagtcg aatggatatt
    10081 ctttttcatc aaggagggta ttgatgacct ctaagcttgc atcaatcact tctttatctg
    10141 tatagcggta tttataaata tagctctccc ggagtgtcac ttctgaaaca tggaaaacta
    10201 catactttgc tccaacttgt tctgcatagg caagatcgtc ccgcaaactg ttcagataag
    10261 attccctgct cattcctcca aagtattcca gccactgctc tcttgaatca aattcctgat
    10321 ctaggcgttc ataattcccc ttccaccagt ccatccagaa aatatgaaaa tacagatgta
    10381 ccccattcac catatccggc agaatctttc cttcatctgg ctcgcctgcc cgaatcactt
    10441 ccagtccatt taatcctcgt gactcataag actttctaat atcttcacta tctttataac
    10501 gatttagcat cccttcataa attgaaaaat tcatggaacg acattctggt attttctgca
    10561 tagtttcccc cttcaatctc gtatactctc agaatctttc taagaataca ttttatctat
    10621 acttatcatc catacttatt tcaaaaatgc cccatcattc tggcaatctt tctaaagttc
    10681 aaaaacgccc cggctattca tctcatcaga tcatatttta tttttatccg ctgcagcttt
    10741 tccaacaatg gctttgctcc aatccacaga aaaataaatg tagaactggc atgaacaaga
    10801 tctaccggaa tacctgaaat atagattgca agcagtcctt cccatgtaaa atcatacaca
    10861 ctcataaaga gagccgctgg attcataatt cctccataaa tgaacaccgt cacaaggaat
    10921 ccatatatac aaaggctgag ccgtttggtc ggaagcagtc ctattcggta aaggattcct
    10981 gacaaaaatc cgataaaacc catcgcaaac atctgccatg gggtccatgg tccctgccca
    11041 aataagaaat tgctgactac catcgtcatg gcaccaacta agaatcctgc ctcgccgcca
    11101 aatgcgattg cactgatgat cacgattgct ataatcggct taaagctcgg tatcataaaa
    11161 aatgctgccc ggccggcggt tgccaatgct accattgttg caagaacaac tagctctctc
    11221 acctgaggtt ttcgtccctc aaataccata aaaaacggta ataacgagta tataatgatt
    11281 accaggctaa taaaataata ctttcttgga ccaaaaatct tttcaaatac tgtgccaacg
    11341 gcggcaacat ccataacata aaatccgaca gcaattgtga ggggaatcgc tacaagcaag
    11401 agaaagagac ttactctggt acgaacagaa agcctgcgtt tttcctgctt tttccagatt
    11461 tcggtatcca tctcaaacat atcattatct aaaatgacat ctcctgccct gccttctcct
    11521 gacaaatctc ctgctaattc ttttaaagca gaagctttcc tgctttttgg taaaaagata
    11581 cgctttatct ttgcagaaat cgtatcttca ttcacgattg gagaagcgta aaattctttc
    11641 aagaactcct gacttgattt ccagtctgcc attgttcaca ctcctttttt aagacatttc
    11701 acaacgtcct ccccggtaac cgccatggga aaataccttc tagccattcg gtttgccgct
    11761 gttgtataaa aattatttcc ggcaaagaat tctcccggag ttccacatgc cacaatattt
    11821 ccatcaaaaa acaaaccaca tcggtctgca taagaagcgc agaactcaat atcatgagaa
    11881 atcataaaaa cagttacgcc ctgctctttg agtaatgcca gtattccggc aaattctttt
    11941 ttaaaatagc tgtcaagtcc tttggtcggt tcatccatca acaaaagctt tggccgcaat
    12001 aacaaaatct tagccagggc aagcctctgc tgctctcccc cgcttaagtc atacggatga
    12061 cgatgcagta attcttccaa atgtgttact ttaatgattc cttccaccgc atccttttta
    12121 tccatggcaa gctgatattc ttcatccttt ttctctttta caccgcctac catttcaaac
    12181 agttctaatt ccacactttt ctttacaaaa agggactgcg ggttttgcgg cagtactcca
    12241 agaaaattgc ggaacagttc tttatcgctg taacgacgga tatccttacc ttctaaaagt
    12301 acttttccac gatatggctt tctcaaacgg ctcaaaagtg aaagtgttgt tgacttcccg
    12361 gttccatttc ctccaagcaa tgcaaagaat tctcctcttt ttaagaaaaa gcttagtccc
    12421 tttacgacat ccggcagttc tttatcatag cggaaccaca gatcatcaca cgctaagatg
    12481 atatcttctt ttttctctgt aaacttttct gtaatcttag caaaagaaga ttttcctttt
    12541 tgggaatcac tctcttttct atatgaagaa gatgcatttg ctggtgaaat gccttttttc
    12601 ttgcaaacta tgtccagcca ctttcgcccg tcacgaacag taatcgggca gggctgctct
    12661 gactctactt tggcataaac ctgcatcggc accggcatag ctaaaaacat ctcatgattg
    12721 cgcttcttta attcttctcc gatttccggc ggtgtgccaa cacataaaat ctgcccttca
    12781 tccatgacca ctaccctgtc agcagaagga aatacttcct ctaaacgatg ttccgtaaga
    12841 ataattgtcg ttccaagatc acgattaatc ttctttactg tttccaaaaa atcagaagct
    12901 gcaatcggat caagctgaga ggtcggctca tcaagaatca gcatatccgg atgcatggcc
    12961 atgatagatg ccagattcaa aagctgtttc tgtcctccgg aaagttccga tacattttta
    13021 taaaaccagt cctgaatccc aaaataactt gccatttccg ctacccggat acggatatct
    13081 gcgttactgt atccaaggct ttccaaacca aatgccagct catgccacac tttatctgtc
    13141 acgatctgat tatccggatt ctgtaataca tatccaatcc tctgactctg ctcccggtta
    13201 ctcatctccc cgattggtac tccctgaaaa aggatctctc cttttcgctt tccatgcggc
    13261 gtcaggggag tctttaaatg tgtcagaagt gtactctttc cacatccact ctttccgcaa
    13321 agaacaagga attccccgtc ctccacatgc aaagaaacat gatttagcgc cctctttttt
    13381 tcttctggat aagcaaaaca caaatcattg atttctaata tactattttt cttttctgac
    13441 aaaccattcg ctgtcaccct gcacctccaa acttgctttt tatctcctgt atatacggct
    13501 attcaacttc ccacaaacgg tacccagccg gtgctgcact ttctacctgt cctcttctcg
    13561 ccttccacat ccttcggtct aaaatctcca tcgctgctgg catgatacta aacaataaaa
    13621 aagcggcaaa gacaagcagg ctgcctgctg taaagggtac tccctttaca acaatccgag
    13681 gattataaga acaaaatgca tacccctttg aaaagcccca catcgctgct ccgaatgtaa
    13741 tgatcataaa aataaggcac aaaaaatccc ttttatcgaa atgatataag gaaaaggcgg
    13801 ttctgccctt ctctccatat ccccggcact tcattgaatc cgatgtttca atcgcattct
    13861 ccaaagacca ggtaaccaga atcgaaaaaa ttgtaattcc atgctttgct ctcttaataa
    13921 ggctcccatt ctctacactt cgcccgacac acttttgccc atcagaaata acagatgctt
    13981 ctttgataaa cttcggtaca aagcgaaggc acatggaaag tactaaagaa agtgccggga
    14041 tgatccttcc aaaaagataa ataaacttat ctgatgtcat aacaactgtg tagcaggaaa
    14101 accatacaag agtacatacc agcatcactg ccatcacaag accgtacaca caactttcta
    14161 atgtaaacgg atttccatta tgaagatatc ctataatcgt tactccataa tgattaaaca
    14221 tcggattgat cagggcaaca ataatcatca tcggtaatga gaagagcaga ttaaacttta
    14281 ctgtcttttt ccatcctttt aaaacaacgg aatacgcaac agcgcatata aatgaaattg
    14341 ccagaatcac aggatgaaca acaaacatcg tcaccccgat tgtcccgcaa aaatacagca
    14401 tatttaaaac aggatgatat gtcgaaaatg tatctttcat ctaaattaaa tctccattac
    14461 atcaaatttc tattacatta aa
//
