LOCUS       c00011_gnlPro..        14450 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BGKMOBBC_11.
ACCESSION   c00011_gnlPro..
VERSION     c00011_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 19:35:44
            Original ID  :: gnl|Prokka|BGKMOBBC_11
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14450
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14450
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[166:4450](-)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(167..4450)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14450
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14450
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(167..4450)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_1"
                     /sec_met_domain="HGD-D (E-value: 8.6e-60, bitscore: 195.3,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 1.3e-37, bitscore:
                     121.9, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENNTLHKLGIDIGSTTVKVAILDQEDRLLFSDYERHFANIQETL
                     SSLLQKAYDALGDFAVAPMITGSGGLTLAKHLGVPFVQEVIAVSTALQHYAPQTDVAIE
                     LGGEDAKIIYFEGGNVEQRMNGICAGGTGSFIDQMASLIQTDATGLNEYAKNYKAIYPI
                     AARCGVFAKTDIQPLINEGATREDLSASIFQAVVNQTISGLACGKPIRGHVAFLGGPLH
                     FLSELKAAFIRTLNLDDEHAITPENSHLFAAIGSALNYKPGETTTLVSLRDRLSNGIKM
                     EFEVARMDPLFASQEEYDAFRARHDGHNVRSADLSTYEGNCYLGIDAGSTTTKIALVGE
                     DGSLLYSFYSNNNGSPLATAIRSIKEIYTLLPPKAKIVHSCSTGYGEALLKAALMLDDG
                     EVETVAHFYAAAFFDPEVDCILDIGGQDMKCIKIKNQTVDSVQLNEACSSGCGSFIETF
                     AKSLNYSVQDFAKEALFAKNPIDLGTRCTVFMNSKVKQAQKEGASVADISAGLAYSVIK
                     NALFKVIKLSDASQLGKNIVVQGGTFYNDAVLRSFEKIAGVECVRPDIAGIMGAFGAAL
                     IARERHEAGYQTSMLSIEQINALTFNTKLARCQGCTNHCLLTINRFSGNRQYITGNRCE
                     RGLGKEKNKDNIPNLYEYKNKRLFDYTPLSAEEAARGTVGIPRVLNMYENYPFWATFFK
                     KLGFSVVLSPQSTRKIYELGIDSIPSESECYPAKLAHGHVTWLIHQNVDFIFYPCIPYE
                     RNEFPDSNNHYNCPIVTSYAENIKNNVDEITSGQVKFLNPFMSFASEETLSSQLIKTFG
                     QSEFGIPESEIRDAVAEGWKELAVCRMEMQKKGEEVLQYLKETGRRGIVLAGRPYHVDP
                     EINHGIPELITSYGIAVLTEDSISHLQPVERPLIVMDQWMYHSRLYAAANYVKTRDDLD
                     LIQLNSFGCGLDAVTTDAVNDILTKSGKIYTCLKIDEVNNLGAARIRIRSLISAIRVRE
                     KKQTKRTIVPANYNRVVFTEEMRKNYTILCPQMSPIHFELLEPAFQTAGYNLVVPDVDS
                     RTCVDVGLKYVNNDACYPSLIVVGQLMAAVMSGGYDMSRTAVLISQTGGGCRASNYIGF
                     IRRALEKAGYPDVPVISINLSGLEKNPGFKLTLPLIQHGLYALEFGDIFMRCVYATRPY
                     EAVAGSTDELHEKWKKEVIAFITQKKMLSHGKFKKMCREIIRDFDNLPRKDIKKPRVGV
                     VGEILVKFHPAANNHLVELLESEGAEAVVPDLTDFLLYCFYNTGFKADNLGMSQKSKKI
                     GRLGINFFEWLRSAARDEFTKSRHFTAPAHIDDLARYARDIVSEGNQTGEGWFLTGEML
                     ELIHTGTPNIVCTQPFACLPNHVVGKGVIKELRHRYPGSNIVAIDYDPGASEVNQLNRI
                     KLMLSTANKNLAKQNAPEQKDQAAG"
     CDS             4712..5569
                     /locus_tag="ctg11_2"
                     /transl_table=11
                     /translation="MNWLNKLERKFGNWAIPNLIVWLIGAYTIGFVLYQVNPSIIGLLM
                     LSPYHILHGQIWRLITWVFMPTDTNLVYLLIMALFYYQLGTTLERTWGTFRFNVYIFGG
                     MLFTVIGAFLLYGIMYLMNGGVTTEMLLIGTSFSTSYINMSIFLAFACMYPDMQVLLMF
                     IIPIKMKWMAAVYGVLIALSFFETGWAGRMAIFMSLLNFIIFFFSTRNLKRYTPHEVHR
                     RQKFKADMRTTQGYAGGAKHKCAVCGRTELDDPTLEFRFCSKCEGNYEYCQDHLFTHQH
                     IRMS"
     CDS             complement(5645..6745)
                     /locus_tag="ctg11_3"
                     /transl_table=11
                     /translation="MAGSTLGTLFKITTWGESHGKGVGVVIDGCPAGLSLCEADIQKFL
                     DRRKPGQSRYATPRKEDDGVEILSGVFEGKTTGTPISLVVFNHNQQSRDYSEIASYYRP
                     GHADYTFDQKYGFRDYRGGGRSSGRETIGRVAAGAVAVKILNELGITFMTYTKSIGPIA
                     VSSGHFDFSEVTKNPLYMPDAEAAENAENYLDACMTELNSSGGIVECIIKGMPAGIGDP
                     VFEKLNANLAKAVMSIGAVKGFEIGDGFDVAKATGKNNNDAFVLGEDGRIAKATNHAGG
                     ILGGMSDGSDIILRAAIKPTPSIAATQRTVNQSGEEISVNIKGRHDPIIVPRAVVVVES
                     MAAITIVDSLFSNMSARMDALKDFYS"
     CDS             6870..8195
                     /locus_tag="ctg11_4"
                     /transl_table=11
                     /translation="MIEKYLVKKITEPVDWKVTVPGSKSMTNRALLLAALSAGTVRVEG
                     VLFSDDSRHFLACLVALGFTVEIEEEKKCVTVTGCGGRIPSGEAAIDVGSAGTAARFLA
                     AMLGFSDGCYEIRCSAQMKRRPMAELFELLSGAGAKITFLEEEGHLPVRITGCRSARAD
                     ETAGETPRRLSLDITKSTQFLSALLLIAPMVPEGMKIHITSEKTDGSYIRITRKMMQEF
                     GVSVAFDGRDYEVPHRSSYRKEAYTVEPDMSAACYFYAAAAVTGGRALVRHVHMDNTQG
                     DLRFLEVLEHMGCTADDTPEGVRVTGPADGALRGITVNMNDFSDQALTLAAIAPFADAP
                     VRIEGIGHIRGQECDRIHAIQTNLTALGIRCEEEETAVTIYPGSPHGGSVETYDDHRVA
                     MAFSLIGLRTDGIVIENPACCRKTFENYFTVLSELTGKTAED"
     CDS             8309..9460
                     /locus_tag="ctg11_5"
                     /transl_table=11
                     /translation="MYELLKQEGRAKRGVFHTVHGDIQTPVFMNVGTVAAIKGAVSTED
                     LEQIKCQVELSNTYHLHVRTGDKLIKEVGGLHKFMSWNRPILTDSGGFQVFSLAGLRKI
                     KEEGVYFHSHIDGAKIFMGPEESMQIQSNLGSTIAMAFDECPPALAERKYVEDSVARTT
                     RWLERCKNEMQRLNGLEDTVNRHQMLFGINQGAIYTDIRIDHAKRISELDLDGYAVGGL
                     AVGETHEEMYHVLDETVPYLPVNKPTYLMGVGTPANILEGVERGIDFFDCVYPSRNGRH
                     GHVYTNQGKINLFNQKYEKDMRPIEEGCGCPTCRRYSRAYIRHLLKAKEMLGMRLCVLH
                     NLYFYNTMMEEIRDALDAGNFASYKEEKLYSMGQINREKEMAK"
     CDS             9559..9876
                     /locus_tag="ctg11_6"
                     /transl_table=11
                     /translation="MFSILATESASSAGWISMVVWLVILFAFMYFFMVRPQKKEQQKKN
                     SMLAELAVGDTILTTSGFYGTVIDIADDTVIVEFGSNKNCRIPMQKAAISAVEKPEDVT
                     E"
     CDS             9965..12460
                     /locus_tag="ctg11_7"
                     /transl_table=11
                     /translation="MKSKKNTLVSRAAVGCVTTAIFLLLCIIKGIYPFGIATLDTVDFQ
                     SQWIPAYYHVWDVLHGDGSAFFDWRVGGGNNFAGVSAQFSLLSPFNLFFLFVKRSWIEK
                     SMIVFLLIKLLVMGYGMRWFLKEQILKEERYGIYILAGSVGYAVNGYTLLYYGMGWLDV
                     AAILPLLCYFFCRMAEREGDWRLGKNTLGYIVCLTLVFLINIPQAYMMCFFLIVFAGGY
                     FFLKRQDQPLKKNGILKFGLTSLLSLGIAAVIFLPAARAMLGSYRLSGEEYRGISGYFL
                     LLRQDGMDAVWKWVILGSVAVPLLFFVISGRRKREHIWQWYLVAAMVLPVFFEAVNLIW
                     HRGTYVCFPMRYGYMLVFAVICMAAARVPDFVGDSRVRRNILYAFLGIWCVQMVALGIS
                     LIQPETHTDETDFVGDATEIGQPLEGKTDVFHKAKLADGAIDNNYPLIAESTSYSNYLH
                     LMTSEQISMNTLLGYSQVWTRLSDTGGTLASDIMLGYRYYVASKAGSWGKDTAADSFWP
                     LAETEKFTLWENAPVGDRAFFITKADYEAYAATEAYTENVFENQNRLSELLFHTVPIDW
                     EKETYLDDQTGAELSYRFHADGKQILYLYGKDLQQAEITVNGKRLYVPDYNDLYNESYP
                     ATGNGGILSIGCFADEDITVDIRQSVGNSGAERAVFFGLLDPQELLEAVDTAGRSVTYE
                     LDRDSCKLTVESAGEEYLMLPINADGGWHCTVNGEERTISRLAGNLMLVPLDAGTNEIT
                     LCYVPRGMKKGAAVTGIALMLLAGWGFLSRLLRRESVLDKIYAGLGYAATGIFAVVYAG
                     FLLVVYVIPVVYTIYLRWI"
     CDS             12470..13954
                     /locus_tag="ctg11_8"
                     /transl_table=11
                     /translation="MEKLQARKKVYLWLLILLSLCALIPLAVLSKYNHQSGDDYGYAYR
                     TFQIWRESHSFWNVIKEAFATSAEFYQKWQGLYASAVLLALEPGIFGDKYYALTGILLL
                     GIIVGSNCAGTVYIFHRKCGCRKLEGFAVGCVMSFLMIEWMPSALQGLYWYNGAMNYVF
                     FHAVLLLLLCVLLSLAGEHPRRRAGRTVIAVLLAVLLAGGNHVTAFMGILLIAGFGIFA
                     AVKKRWQNLICCAITLVAILAGFLFNVTSPGTRIRQSYFSDRPGVAGTIVTAVKNGIAC
                     INSWMGLAVIVTAVLLLPVLLSMVTKIRGQYGFSFRYPLLVFVLSVAWLCAMFCPPIYA
                     MGTPGDVRLTNVVYFSFVWLFVLNEAYLCGWVVTKLEASGAAGLCSRAGELTDSFLITA
                     AVLAVGMIIGCGENMTAWQAYLLIRSGEAQEYSAEADERYAVLCDSAGEDVVLKSYTAK
                     PWMLFLDDITEEKSDWRNEYMRVYFGLNSVVLEQTE"
ORIGIN
        1 ggatcatcga agatgcaaac atccggctgg ttagaaatgc cacatttttt gaaccaaatt
       61 ttcctctgta tctccatctg aaatcccacg gtgtgatctt ctgataatat tacttatcac
      121 gaaaaggggc tgcacatttg atgcgcagcc cctttctctg tatctgtcag cctgcagcct
      181 gatccttctg ctccggtgcg ttctgctttg ccagattttt gttcgcggtg gagagcatca
      241 gcttgatacg gttgagctgg tttacctcgc tggcacccgg atcgtaatcg atggccacga
      301 tattggaacc cggatagcgg tgacgcagtt ccttgatgac gcccttgccg accacatggt
      361 tcggcaggca ggcgaatggc tgcgtgcaga cgatgttcgg tgttccggtg tggatcagct
      421 ctaacatctc accggttaag aaccagccct cgccggtctg gttgccctcg gatacaatgt
      481 ctcttgcata tctggcaaga tcatcgatgt gcgcaggtgc agtaaagtgc ctgctctttg
      541 tgaattcatc tcttgcagcg ctgcgcagcc actcaaagaa attgatgccc agacggccga
      601 tcttcttgga cttctggctc atgccgagat tgtctgcttt aaagcccgta ttgtagaagc
      661 agtagagcag gaaatcggtc agatccggta caacggcctc tgcaccctcg gattcgagaa
      721 gctccaccag atgattgttg gcagccggat ggaacttgac aagaatctcg ccgacaacgc
      781 cgacgcgcgg tttcttgatg tctttgcgcg gaaggttgtc aaaatcgcgg atgatctcgc
      841 ggcacatttt cttgaacttg ccgtgggaga gcatcttttt ctgggtaata aaggcgataa
      901 cctctttttt ccatttctcg tgcaactcgt ccgttgatcc ggcaaccgcc tcgtaagggc
      961 gcgttgcgta gacgcagcgc atgaagatat cgccaaactc cagcgcgtag agtccgtgct
     1021 ggatcagtgg cagtgtcagc ttaaagcccg ggtttttctc cagaccgctc agattgatcg
     1081 agatgaccgg aacgtccgga tagccggctt tttccagtgc acgccggatg aagccgatgt
     1141 aattgctggc gcggcagccg ccgccggtct gggagattaa gaccgcggtg cgcgacatat
     1201 cataaccgcc ggacatcacg gccgccatca gctggccaac cacgatcagg gacgggtagc
     1261 aggcgtcatt gttgacgtac tttaagccga catccacgca ggtacggctg tccacatccg
     1321 gaacaacaag gttgtacccg gccgtctgga acgccggctc caacagctca aaatggatcg
     1381 gtgacatctg tgggcagagg atggtgtaat tcttgcgcat ttcctccgtg aagacgacgc
     1441 ggttgtaatt cgccggaacg atggtgcgct tcgtctgctt cttctcacgg acacggatcg
     1501 ccgagatcag ggaacggata cggatgcgcg ccgcaccaag gttgttgacc tcatcgattt
     1561 ttaaacaggt gtagatcttg ccggactttg tcagaatatc attgacagcg tctgtcgtga
     1621 cggcgtccag accgcagccg aaagaattca gctggatgag gtcgagatcg tctcttgtct
     1681 tgacatagtt cgccgcagcg tacagtctgg agtgatacat ccactgatcc atgacgatga
     1741 gcgggcgctc caccggctgt aagtgggaga tggaatcctc cgtgagcacg gcgatgccgt
     1801 aggaggtaat cagctccgga ataccgtggt tgatctcagg gtctacatgg tacggacgac
     1861 ctgcgaggac gataccgcgt cttccggtct cctttaaata ctgtaagact tcctcgcctt
     1921 ttttctgcat ctccatccgg cagacggcaa gctccttcca gccttcggca accgcgtcgc
     1981 ggatctcgga ttccggaatc ccgaactccg actggccaaa ggtcttaatc agctgggagg
     2041 aaagcgtctc ctcgctggcg aaagacataa acggatttaa gaacttcacc tgaccggaag
     2101 tgatctcgtc cacgttattt ttgatatttt ccgcgtagga ggtaacgatc ggacagttgt
     2161 agtgattgtt ggaatccggg aattcgttgc gctcataagg aatacacggg tagaaaataa
     2221 aatcgacgtt ctggtggatc agccatgtca catgaccgtg tgccagcttt gccgggtagc
     2281 actcggactc gctcgggatg gaatcaattc caagctcgta gatcttgcgc gtcgactgcg
     2341 gggagagtac cacggaaaaa ccgagcttct taaagaaagt tgcccagaac gggtagttct
     2401 cgtacatatt taaaacgcgc ggaataccga ctgtgccgcg tgctgcttcc tcggcggaaa
     2461 gcggggtgta gtcaaacagg cgcttgttct tgtattcgta gaggtttgga atgttgtctt
     2521 tatttttctc cttgccgagg ccgcgctcac agcggttgcc ggtgatatac tggcggttgc
     2581 cggaaaagcg gttgattgtg aggagacagt ggttggtaca tccctgacat cttgccagct
     2641 ttgtgttgaa ggtcagcgca ttgatctgtt cgatggaaag catggaggtc tggtagcctg
     2701 cctcgtgacg ctctctggcg atcagtgcgg caccgaaagc acccatgatg ccggcaatat
     2761 ccggacggac acattcgacg ccagcgattt tctcaaaact gcgcagtacg gcatcgttgt
     2821 aaaacgtacc gccctgtacg acgatatttt tcccgagctg gcttgcatcg gaaagcttga
     2881 ttaccttaaa taaagcattc ttgatgacag agtacgcaag acccgcagaa atatctgcaa
     2941 cggatgcgcc ctctttctgc gcctgcttta ccttggaatt cataaatacg gtgcagcggg
     3001 ttccaagatc gatcggattt ttggcaaaaa gagcctcctt tgcaaaatcc tgtacagagt
     3061 agttgaggga ttttgcaaac gtctcgatga aagaaccgca gccggaggaa caagcctcat
     3121 tgagctgtac ggaatccacc gtctgattct tgatcttgat acatttcata tcctgaccgc
     3181 cgatgtctaa gatacagtcg acttccgggt cgaagaacgc ggccgcatag aaatgagcca
     3241 ccgtctcaac ctcgccgtca tcgagcatca aagcggcttt taacagcgct tcaccgtatc
     3301 cggtggagca ggagtggacg atctttgcct tcggtggaag gagcgtatag atctccttga
     3361 tggaacggat tgccgttgca agcggacttc cattgttgtt gctgtagaaa gaatacaaaa
     3421 gggaaccgtc ctcgccgact aaggcaatct tggtcgtggt ggaacctgca tcgatgccca
     3481 gatagcagtt gccctcataa gtggagagat ctgcggacct gacattgtgt ccgtcgtggc
     3541 gcgcacggaa agcgtcgtac tcttcctggc tggcaaacag aggatccata cgggcaacct
     3601 caaattccat cttgatgccg tttgagagcc ggtcgcggag agagacgagc gtggtcgtct
     3661 cacccggctt gtaatttaaa gcggaaccga tcgcagcaaa cagatgggaa ttctccggtg
     3721 tgatggcgtg ttcgtcgtcc agattcaagg tgcggataaa agcagccttg agctcggaaa
     3781 ggaagtgaag cggacctccg agaaaggcaa catgaccgcg gatcggctta ccacaggcaa
     3841 gaccgctgat cgtctgattg accactgcct ggaaaatgga ggcagagaga tcctctctgg
     3901 tagcaccctc gttgattaac ggctggatat cggtcttggc aaagacaccg caacgcgcag
     3961 cgatcgggta gatggccttg taattcttgg cgtattcatt cagaccggtc gcatccgtct
     4021 ggatgaggga tgccatctgg tcgataaaag aaccggtacc gccggcacag atgccgttca
     4081 tacgctgctc gacattgccg ccctcaaaat agatgatctt ggcatcctca ccaccgagct
     4141 cgatggcaac atcggtctgc ggtgcataat gctgcagggc agtggacacg gcgatcactt
     4201 cctggacaaa cggaacaccg agatgcttgg cgagtgtcag gccgccggaa ccggtaatca
     4261 tcggagcgac agcaaaatcg ccaagggcat cgtaggcttt ctgaagaagg gaggataagg
     4321 tctcctggat attggcaaaa tggcgctcat aatcggagaa gagcagacgg tcctcctggt
     4381 ctaaaatagc aaccttgacg gttgtggaac cgatgtcgat tcccaattta tgaagtgtat
     4441 tgttttccat aattccctcc atggttgttt ctcgtaaagt aaatacttta gcagagtaaa
     4501 atatgtaaaa gatttcttct tattataaat agtgccaatc tggcgctaaa cactctacat
     4561 tatacgacag gatatgtcaa aagacaatgt gcattttgcc ggaaaagtat aaactttttg
     4621 taaagaaaaa cccctctgat tgacaaagat ttccctgacc gatatactga acaacgtaat
     4681 gtcatttttg gaaaggtcag gaacagagtg tatgaactgg ttaaataaat tagaacgtaa
     4741 attcggcaac tgggcgattc ccaatctgat cgtgtggctg atcggagctt acacgatcgg
     4801 gtttgtgctc taccaggtga atccgtcgat cataggactt ttgatgttga gtccgtatca
     4861 catcctgcac ggacagatct ggcgtctgat tacctgggtg tttatgccca cagacacgaa
     4921 tctggtgtat cttctcatta tggcgctttt ctattatcag cttggaacga cactggagcg
     4981 cacatgggga accttccggt ttaacgtcta tattttcgga ggtatgctgt ttaccgtcat
     5041 cggagcgttt ctgctgtacg gtatcatgta tctgatgaac ggcggtgtga cgacggagat
     5101 gcttctcatc ggaacgagtt tcagcacaag ttacatcaac atgtccatct tccttgcgtt
     5161 tgcatgtatg tatccggata tgcaggttct tctgatgttc attatcccga ttaagatgaa
     5221 gtggatggcg gctgtgtacg gcgttctgat tgctttaagc ttttttgaga ccggatgggc
     5281 gggaagaatg gcgattttta tgtcgctcct caactttatt attttcttct tctccaccag
     5341 aaacctcaag cgctatacgc cgcacgaggt gcacagacgc cagaagttta aggcagacat
     5401 gcgaacaacg cagggatatg cgggcggtgc gaagcacaag tgtgctgtct gcggcaggac
     5461 ggaacttgac gatccgacgc tggaattccg tttctgctcc aagtgcgagg gcaattacga
     5521 atactgtcag gatcatctgt ttacacatca gcatattcgg atgagctaga aagtatgaaa
     5581 aagaaaaagg tgatacttcg attccgtcag ccggcgtaga agaagtatca cctttttgtt
     5641 tcttttagga gtagaaatct tttagcgcat ccatccgtgc gctcatattg gaaaagagtg
     5701 agtcgacgat cgtgatggcc gccatggatt ccaccacgac aacggcgcgc ggaacgatga
     5761 tcggatcgtg gcgtcccttg atgttgaccg agatctcctc accggactga ttgacggtgc
     5821 gctgtgtggc ggcgatggaa ggggtcggct tgatggcagc ccggaggatg atgtcgcttc
     5881 cgtcgctcat gccgcctaag ataccgccgg catggttggt tgctttggca atcctgccgt
     5941 cctcaccgag gacaaaggca tcgttgttgt tcttgccggt cgcttttgcc acgtcaaatc
     6001 cgtccccgat ctcaaaacct ttgacggcgc cgatggacat gaccgccttg gcaaggtttg
     6061 cattcagctt ctcaaagacc ggatctccga taccggcagg cattcctttt atgatacact
     6121 ccacgatgcc gccggaggaa tttaactccg tcatgcaggc atccagataa ttttcagcgt
     6181 tctcggccgc ttcggcgtcc ggcatataga gtggattctt tgtgacctcg gaaaaatcaa
     6241 agtgcccgga agatacggcg atcgggccga tggactttgt gtaggtcata aaggtaatgc
     6301 cgagctcgtt tagaatcttg acggcgacgg cgcctgcggc gacgcgtccg atggtttccc
     6361 gcccggagga gcgtccgccc ccacggtagt cgcggaagcc gtatttctgg tcgaatgtgt
     6421 aatcggcgtg accgggacgg taataggagg cgatctcgct gtagtctctg gactgctgat
     6481 tgtggttgaa aacgacaagc gagatcgggg tgccggtcgt ctttccttca aacacgccgg
     6541 agaggatctc tacgccatcg tcctccttgc gcggggtcgc atatctggac tgaccgggct
     6601 tgcgccggtc gagaaacttc tggatatccg cttcacagag agaaagtccc gccggacacc
     6661 cgtcgatgac gacgccgaca ccctttccgt gagattcccc ccaggttgtg attttaaaaa
     6721 gagttcccaa tgtagaccct gccatgtgat tccctcctgc ttacataatg atctttctcg
     6781 attataaaag atttgacttt gcgccgcaac agaaatatgt tatgatttga cggagcagaa
     6841 gtaccagcag gcgaggagaa gaatatttca tgatagagaa ataccttgtg aaaaagataa
     6901 cagagccggt ggactggaag gtaaccgtgc cgggatcaaa gagcatgacg aaccgcgcgc
     6961 ttcttttagc agcgctgtcc gcagggacgg tgcgcgtgga aggcgttctg ttttccgatg
     7021 attccagaca ttttctggcg tgtcttgtgg cgctcggctt tacagtggag atagaggaag
     7081 aaaaaaagtg cgtgaccgtg acgggctgcg gcggcaggat tcccagcggg gaggcggcaa
     7141 tcgacgtcgg aagcgctggg acagcggcgc gtttccttgc ggcgatgctc ggattttcgg
     7201 acgggtgtta tgagatccgc tgttcagcgc agatgaagcg gcggccgatg gcggagctgt
     7261 tcgaactgct ttccggtgcg ggggcgaaga ttaccttcct cgaggaggaa gggcatcttc
     7321 cggtgcgcat cacagggtgc agatctgccc gggcagatga gacggcaggg gagacgccgc
     7381 ggagactctc ccttgacatt acgaagagca cacagttttt aagcgcgctg ctattgattg
     7441 cgccgatggt tccggagggg atgaagatcc atattaccag tgagaagacg gacggctcat
     7501 acatccgcat cacgcggaag atgatgcagg aattcggcgt gagtgtcgct tttgacggaa
     7561 gagattacga ggtgccgcac agaagttcct accggaaaga ggcttatacg gtggaaccgg
     7621 atatgtcggc tgcctgctat ttttatgcgg ctgcggctgt gaccggcgga cgggcgcttg
     7681 tgcggcatgt gcatatggac aacacacagg gagatctgcg tttcctggaa gtgttggagc
     7741 acatgggatg taccgcggac gatacgccgg agggcgtccg ggtaacggga ccggcggacg
     7801 gtgcgttgcg gggcatcaca gttaatatga acgatttctc cgatcaggcg ctgaccctgg
     7861 cggcgatcgc gccgtttgcc gacgcgccgg tgcgcataga gggaatcgga catatccgcg
     7921 ggcaggaatg cgaccggatt cacgcgatac agacgaacct gacagcgctt ggcatccggt
     7981 gtgaggagga agagacggct gtcacgatct atcccggcag cccccacggc ggaagcgtgg
     8041 agacatacga cgatcaccgc gtggcgatgg cattttccct gatcgggctt agaaccgacg
     8101 gtattgtgat tgagaacccg gcatgctgcc gcaagacgtt tgaaaattac tttaccgtgt
     8161 taagcgaact gaccgggaaa acggcagaag attgacgggg caccggtttt gcatgagcca
     8221 gggaagcaga agtgcagaac gacagtaagt aaatagagaa gaacgacagg taataaacga
     8281 caggtaataa aaggagacga aaaaacagat gtatgaatta ttaaagcagg aaggacgcgc
     8341 gaaacgaggc gttttccata cggtgcatgg agatatccag acgccggtgt ttatgaatgt
     8401 gggtacagtg gctgccatca agggagctgt ctccacggaa gatttagagc agatcaaatg
     8461 tcaggtggag ctgtcaaaca cctatcatct gcatgtgcgc accggagaca agctgatcaa
     8521 ggaagtggga ggactgcaca agtttatgtc gtggaatcgt ccgattctta cggattccgg
     8581 cggatttcag gtgttctccc tggcaggcct gcgcaagatc aaggaggagg gcgtctattt
     8641 ccactcgcat attgacgggg caaagatttt catgggaccg gaggagagca tgcagatcca
     8701 gtccaatctc ggttccacga tcgctatggc gttcgatgaa tgcccgccgg cgcttgccga
     8761 gcggaaatat gtggaggatt ccgtggcacg gacgacacgc tggctggagc gctgcaagaa
     8821 cgagatgcag cgcctcaatg ggctggagga taccgtgaac cgtcaccaga tgctgttcgg
     8881 catcaaccag ggagccatct acacggacat ccggatcgac catgcaaagc ggatttccga
     8941 gctggatctg gacggctatg cggtcggcgg acttgcggtc ggcgagacac acgaggagat
     9001 gtaccatgtg ctggatgaga ccgtgcctta tcttccggtg aacaagccga cctatctcat
     9061 gggagtcgga acgccggcca atattctgga gggagtggag cgcggcattg acttcttcga
     9121 ctgtgtttat ccgtcccgca acggccgaca tggccatgta tacacgaacc agggcaagat
     9181 caacctgttc aaccagaagt acgagaagga tatgcgcccg atcgaagagg gctgcggctg
     9241 cccgacctgc cgccgctaca gcagagccta tatccgccat ctgctcaagg caaaagagat
     9301 gcttggcatg cgcttatgtg ttctgcacaa tctgtacttc tacaacacga tgatggaaga
     9361 gattcgggat gcgctggatg ccggaaactt tgcctcctac aaggaagaaa agctatacag
     9421 catgggacag atcaaccggg aaaaggaaat ggcaaagtaa aagggaaaag gcttgccaaa
     9481 cggcgaggtt ttgtgtacaa tactttctaa tggggtcaga cgacttcgga caagtttatg
     9541 attttaggag gatatcagat gttttcaatc ttagcaacag agagcgcgtc atccgcaggc
     9601 tggatcagca tggtggtatg gctggttatt ttatttgcat ttatgtattt cttcatggtg
     9661 cgtccgcaga agaaagagca gcagaagaag aactccatgc ttgcagagct ggcagttgga
     9721 gatactatct taacgacaag cggtttctac ggaaccgtga tcgacatcgc agacgatacg
     9781 gtgatcgtgg aattcggaag caacaagaac tgccgcatcc cgatgcagaa ggcagcgatc
     9841 tccgcagttg agaaaccgga agatgtaact gaataagaag attttaaaga gggatagtat
     9901 ataaaatgta ttatcccttt tctttttgag agagtatttg ggagagcgag gagagattgg
     9961 tcggatgaaa agtaaaaaga atacgcttgt ttcacgtgcc gccgtcggct gcgtgacaac
    10021 tgccattttt ctgctgttgt gcatcataaa gggcatctat ccgtttggaa ttgccacgct
    10081 tgacactgtg gattttcagt cccagtggat tccggcatat taccatgtat gggatgtgct
    10141 gcacggagac ggcagcgcct tttttgactg gagagtcggc ggcgggaata attttgcggg
    10201 agtgagcgcg cagttttctc tgctcagccc gtttaacctg ttcttcctct ttgtgaaaag
    10261 aagctggatt gaaaaatcca tgatcgtgtt tcttttaatc aagctgctag tcatgggcta
    10321 tggcatgcgc tggtttttaa aagagcagat ccttaaggaa gagcgttacg gaatctacat
    10381 tctggcggga agcgtggggt atgccgtaaa cggctatacg cttttgtact atggcatggg
    10441 ctggctggat gtggcagcga tcctgccgct attgtgttat ttcttctgca ggatggcgga
    10501 gcgggaaggg gactggcgtc tcgggaaaaa tacgctcggc tatatcgtct gcctgacgct
    10561 ggtattcctc atcaatattc cgcaggcgta catgatgtgt tttttcctga tcgtgtttgc
    10621 ggggggatat tttttcctga aacgacagga ccagccgcta aaaaagaacg gcattttaaa
    10681 attcgggctg acttctttac tgtcgcttgg aattgcggcg gtaatatttc tgccggcagc
    10741 gagggcaatg cttggttcct accggctgtc gggcgaggag taccggggaa tctccggcta
    10801 ttttctgctg cttcggcagg acggaatgga cgcggtgtgg aaatgggtga ttcttggcag
    10861 cgtggcggtt ccgctgctgt tcttcgttat ttctggcaga cggaagcggg agcacatctg
    10921 gcagtggtat ctggtggcgg cgatggtgct gccggttttc ttcgaggcgg tcaatctcat
    10981 ctggcaccgc gggacgtatg tgtgcttccc gatgcgatat ggttatatgc tggtgtttgc
    11041 cgtgatttgt atggcagcgg cgcgcgtgcc ggattttgtg ggagatagcc gcgtgcggcg
    11101 gaacatttta tatgcgttcc tgggaatctg gtgcgtgcag atggtggcgc ttggcatttc
    11161 tttgatacag ccggaaacgc acacggacga gacggatttt gttggggatg ccacggaaat
    11221 cggtcagccg cttgagggaa aaaccgatgt tttccacaag gcaaagctgg cggacggagc
    11281 gattgacaac aactatccgc tgatcgcaga gagcacctcc tactccaatt atctgcatct
    11341 gatgacgtcg gagcagatca gtatgaacac actgctcggg tattctcagg tgtggaccag
    11401 attaagtgac acgggcggaa cgctcgcgtc cgacatcatg ctggggtacc gttattatgt
    11461 ggcgtctaag gcgggatcgt ggggaaaaga cacggcggcg gattcctttt ggccgcttgc
    11521 tgagaccgaa aagtttacgc tgtgggaaaa tgcgcccgtc ggggacaggg cattttttat
    11581 cacaaaagcg gactatgaag cgtatgcagc cacggaagcg tacacggaaa atgtgtttga
    11641 gaaccagaac cggctgtcgg agctgctttt tcacacagtt cccattgact gggaaaaaga
    11701 gacctatctg gatgatcaga ccggagcgga attatcgtac cggtttcacg cagacggaaa
    11761 gcagatccta tatctctatg gaaaggatct gcagcaggca gaaattacgg taaacggaaa
    11821 gaggctctac gtcccggatt acaatgatct gtacaatgag agctatcctg caaccggcaa
    11881 tgggggaatt ctctccatcg ggtgttttgc ggacgaggac atcacggtag atatccgcca
    11941 gtccgtcggg aacagcggcg cagagagagc ggtgttcttc ggactcctcg atccgcagga
    12001 actgctggag gcggtggata cggcgggaag gtcggttaca tatgaactgg atcgggattc
    12061 ctgtaagctc accgtcgaat cggcgggaga ggagtatctg atgcttccaa tcaatgcgga
    12121 tggcggatgg cattgtacgg taaacggaga ggagcggacc ataagccggc tcgcgggcaa
    12181 tctgatgctt gtgccgcttg atgcgggaac gaacgagatc acgctttgtt atgtgccgcg
    12241 gggaatgaaa aagggcgcgg cggtgacggg tatagccctg atgcttctgg caggctgggg
    12301 ctttctctcg cgtctgcttc ggagagaaag cgtcctggat aaaatctacg ccggacttgg
    12361 ctatgccgcc acaggtattt ttgcggtggt ctatgccgga tttctgctgg ttgtctatgt
    12421 gattccggtg gtgtatacga tatatttaag atggatctga ggtaacagaa tggaaaaatt
    12481 acaagcgaga aaaaaagtat atttgtggct gctgattcta ttgagtcttt gcgcgctgat
    12541 cccgttagcc gtactctcga agtacaatca tcagtcgggg gatgactacg gttatgccta
    12601 ccgtaccttc cagatctggc gggagtcaca ttctttctgg aatgtcataa aagaagcgtt
    12661 tgccacatcc gcggagttct atcagaagtg gcaggggcta tatgcatcgg cggtgctgct
    12721 ggcgctggaa ccgggaattt tcggcgacaa atattatgcg ctgaccggaa ttttgctgct
    12781 cggaatcatt gtggggtcaa actgcgcggg tacggtttat atctttcacc gtaaatgcgg
    12841 gtgccggaaa ctggagggat ttgctgtcgg ctgcgtcatg tcgtttctta tgatcgaatg
    12901 gatgccctcc gccctgcagg gattgtactg gtataacggg gcgatgaatt atgtattctt
    12961 ccatgcggta ctgttattgc tgttatgcgt gctgcttagc cttgccgggg agcatccgcg
    13021 gagaagggca ggcaggacgg tgattgcggt attgcttgcg gtgctgcttg ccggcgggaa
    13081 tcatgtgacc gcatttatgg gaatattgct gattgccgga tttggaatat ttgctgcggt
    13141 aaaaaagcgg tggcagaacc tgatctgctg cgccataacg cttgtggcta tacttgctgg
    13201 attccttttt aacgtgacat cgccgggcac cagaatccgg cagtcgtatt tttccgacag
    13261 acccggcgtg gcgggaacga ttgtcacggc cgtaaaaaac ggaattgcat gcatcaacag
    13321 ctggatggga ctggcggtca ttgtcacggc ggtcctgctg ctccctgtgc ttctttccat
    13381 ggtaacgaag atacgcgggc agtacggatt ttcgttccgc tatccgctgc ttgtctttgt
    13441 gctgtcggtt gcctggctgt gcgcaatgtt ctgtccgccc atctacgcga tgggaacgcc
    13501 gggggacgtc cggctgacca acgtggtata tttttccttc gtctggctgt ttgtgttaaa
    13561 tgaagcctat ctgtgcgggt gggtggtcac aaaactggag gcgtccgggg cggcaggact
    13621 gtgtagcagg gcaggagaac ttacggacag ctttctgatc acggctgctg tccttgcggt
    13681 gggaatgata atcggatgcg gggaaaatat gaccgcatgg caggcatacc tgctgatccg
    13741 cagcggcgag gcacaggaat attcggcgga ggctgatgag cgctacgccg ttttgtgtga
    13801 ttctgcgggg gaagacgtgg tgttaaagtc gtataccgca aagccgtgga tgcttttcct
    13861 tgacgatatt acagaggaga aaagcgactg gagaaatgaa tatatgcgcg tctattttgg
    13921 actgaacagc gttgtgttag agcagacgga atgagacggc agaagggagc agcggacaca
    13981 aaaggcaggc tgctcctttt tcataagacc cggttatagg gagtatgaaa aagaaaaatg
    14041 gattcagagg ttgcattgtt tcccgagata cattattata gaatttatat actgtctgtt
    14101 agtaatgtac taaagtcaat acaagacgga ttcctgcatg gcaggaagaa aagagggatt
    14161 agagagatgg aatataaggt aggcgtgatt tccggcgacg ggatcggacc ggagatcgta
    14221 acagaggcaa agaaagttct ggatcagatt ggaaagatct acggacatgt gttccgctat
    14281 gaagagattc tgatgggagg ctgctccatt gacgcgacgg gtgagccgct cacggatgcg
    14341 gcgatcgctt ccgcgaaggc ttccgatgcg gtgctgatgg gttcgatcgg cggcaacaca
    14401 tcgacttcgc cgtggtatca gctgccgccg gagaagagac cggaggcggg
//
