LOCUS       c00063_gnlPro..        16182 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OCCKCGJO_63.
ACCESSION   c00063_gnlPro..
VERSION     c00063_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 19:39:49
            Original ID  :: gnl|Prokka|OCCKCGJO_63
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1771
            Orig. end    :: 17953
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16182
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[11771:17952]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..16181
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16182
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16182
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             2211..3908
                     /locus_tag="ctg63_3"
                     /transl_table=11
                     /translation="MRSILRSLPAAFRRRGLRIAATLVLRAVLNLAGLAALLPVLTLVL
                     DPAGFEGDGPLATVYVWSGVASPRTFALAVCGAVVGFIVLKCGVNFLLARAERRYIYDL
                     YRTLSRRLYIAYHDRGLAFINNSNSSVLARNVNVVCLAFAAGVLRPAAAMIAEAMLFVL
                     LFASLALYTPLAALLSVVIFLPAVWLYYALVRNRINRYGEQENRAQREKSRLVAETFRG
                     YADIELSDAFPGMLRAFDRTMDEVVRTRSREADIGQLPQLFTEIGLAVGMALLAAVSFG
                     GGQSQLLFGVFAVAALRLMPSVRGIMSGWATIRYNRYTIPILREAALHEPASAHPGVPT
                     RETLPFEREISVRNLSFRFTEESRELFHGLTLTIRKGERIGIRGASGAGKTTLFNLLLG
                     LYEPTSGEIAVDGTPLTAANRRAWQNRIGYVSQRLFLTDGTFAANVAPGVPAAEINRRR
                     VTEALEAAQLGEFIASLPLGIDTPVGECGSRLSGGQRQRIGIARALYRRADVLFFDEAT
                     SALDSRTEGEINRSIAAIAARNPGLTLLVIAHRETSLEYCDRIITLEK"
     CDS             4038..4928
                     /locus_tag="ctg63_4"
                     /transl_table=11
                     /translation="MNANNRFMNYTIANIRVSLPDACTGEHFTRALRPFLTLGAGPADL
                     ALEIVPRIPAEADYRELDIFEFPDADADCRFGTDAAGYLLEMTPRDGSAPARYRMAYGA
                     AAARSDITPGHNPALFRFGVWILFNIAALPLGAVAFHSSVISYRGRGVLFLGESGTGKS
                     THTRLWREHIPGAELLNDDSPIIRATDSEALVHGSPWSGKTPCYRNESCPIAAVVRLSQ
                     APHNRIRRLRPIESIGALLPSAPPAFARDERLSDDTCGLLSRLIAQVPVYHLECLPDAA
                     AAQLACRTVFNDATL"
     CDS             4925..5377
                     /locus_tag="ctg63_5"
                     /transl_table=11
                     /translation="MILLPNQLFFAEVEAMLSEGREVQIRMKGHSMRPLLRSERDQVVL
                     TPCTDPARLRPGDVVLFRCCGRHILHRIVRRDGDRLTLAGDGNYRITEQCTTRDVAGIA
                     VRIIRASGRVVGCDSPGWQLRSRLWLAIPPWLRRQVLRVLWHSGWK"
     CDS             complement(5594..6424)
                     /locus_tag="ctg63_6"
                     /transl_table=11
                     /translation="MEIKAADVMKLRKMTGAGMMDCKKALIEAEGDFARAQDIIREKGK
                     LIVAKRADRTATEGVVVTKIVGQKAYILCLACETDFVAQNSEYSASAEAMLEVAVKNDA
                     ADRDALMAAKNAEGRTVEEMVTEKSGQTGEKIELAYYGRIEAPYCAAYVHFNKKLGTIL
                     GFNKEIPAEVAHTVTMQATAMAPVSISEADCPAEVVEHERKIAVEAMKQDPKNANKPEA
                     ILEKIAEGKMRKFFEENTLLAQPVVGEKESIADYIHKADKDATVVAYKRFALGE"
     CDS             complement(6461..7381)
                     /locus_tag="ctg63_7"
                     /transl_table=11
                     /translation="MSRTDFNTLLEAGAHFGHLKRKWNPKMAPYIFMEKNGIHIIDLHK
                     TVLKIDEAAAAIKQIAKSGRRVLFVATKKQAKDIVAEKVAAVGMPYVTERWAGGMLTNF
                     PTIRKAVKKMSTIDKMATDGTFDNFSKREKLQISRQRAKLEKNLGSIADLTRLPAALFV
                     VDVQKEANAVKEAKRLSIPVFAMVDTCCDPTDIDYVIPANDDATKSIAVVLEAMCAAIA
                     EGTEERKLEKEKEAQEADAEGATVKKEGKPRIKKAVKAAIDAEEAAVAEVVAAVETPYE
                     EPAAAPAEAAEVVAEAAETAEEKAE"
     CDS             complement(7595..7981)
                     /locus_tag="ctg63_8"
                     /transl_table=11
                     /translation="MEVVNTVGRRKAAVARVYVKPGKGQITINRKALEVYFPLEILQYQ
                     VKQPLLATNTAENYDIVINLDGGGITGQASAARLGIARALCEIDAEMRPVLKKAGFLTR
                     DSREVERKKPGQPGARRKFQFSKR"
     CDS             complement(7987..8442)
                     /locus_tag="ctg63_9"
                     /transl_table=11
                     /translation="VDSLSYKTISANAATVTKEWVVIDATNEVLGRLASQVAKILRGKN
                     KPSYTPHVDCGDYVIVINAEKVKLTGNKMTDKVYTRHTGYPGGQRFATPADYLAKKPTF
                     LIEKAVKGMLPKTRLGDKLLSNLKVYAGAEHPHAAQNPKTIKLNEIK"
     CDS             complement(8667..9296)
                     /locus_tag="ctg63_10"
                     /transl_table=11
                     /translation="MGPGALTEPRKLILRFVVGKDGRVTPAPKPKYRDEDALEQTVRQA
                     IAAAPAWTPATIDGERVRFGVSMPVAFGPGAAGAEYSDKDAYRVVEVMPKFFGGGLDKF
                     RSWVMAEVRYPSDMLKRGVQGRVVAAFVVDKEGRITMVEILESPHPQFSEAVARVLGRA
                     PRWTPGRQDGALVRVEYTLPVDFKIRSELRFPSGAAGRNRGSSRSY"
     CDS             complement(9296..9862)
                     /locus_tag="ctg63_11"
                     /transl_table=11
                     /translation="MKRLFMVLFGLASLHAAATAAKTAGEEKTPGKNAGAAASLWPEKM
                     DPSFQGSRPECFKIWVIRNLRFPADRYDVGDEAKVEVVFAIDKNGTLTDLKVTHCEERH
                     FADRLCKTIALSPKWSPGRTKGKPVKTELEMRFVFRLVAPPAGQEELGLCAEECDIHTT
                     ADRMPLFCGAVRTGFVRGCSGRSTA"
     CDS             complement(10001..11212)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_12"
                     /sec_met_domain="OAD_beta (E-value: 4.6e-169, bitscore:
                     552.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWNALTSSSNFVLESLETFAESTGVAGLIANMGWGSLIMICVAFF
                     LLYLAIKHKFEPLLLLTIAFGMLLTNLPGANLYHTELFAGGHVHWDIFVAQAGLLDYLY
                     LGVKLGIYPCLIFVGVGAMTDFGPLIANPKSFLLGAAAQLGIFLTFIGAYALGFSPAEA
                     GSIGIIGGADGPTSIYLTAILAPELLGPIAVAAYSYMALVPVIQPPIMRMLTTEKERKI
                     KMRQLRPVSKTEKILFPLIITVIIALLLPSAAPLVGCLMLGNLMKECGVVDRLSKTVQN
                     ELMNIVVIFLGLTVGATATAEAFLNPRTLFILVLGVIAFAMGTAGGVLLAKVMNFFSKG
                     DNKINPLIGSAGVSAVPMAARVSQTEGQKADPSNFLLMHAMGPNVAGVVGSAVAAGILL
                     SFLG"
     CDS             complement(11217..11678)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 71.2; E-value:
                     1.6e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_13"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.8e-23, bitscore:
                     71.2, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYSLKINGHNYNVQIDDVNEASTVAHVVVNGVDYEVEIEGAKA
                     STVSKPQVSPAPKSANSAMITPSTATPSPRIAPAPSTSGSSVKCPLPGTVLSVKVAVGD
                     TVAAGQTLVVLEAMKMENNIDADRAGVVKQILVQQGATVMEGDVLIVIG"
     CDS             complement(11715..12035)
                     /locus_tag="ctg63_14"
                     /transl_table=11
                     /translation="MNWGWSEILWVSLIGFSLVFILLVALIFIMKAFGACFRVRPASGR
                     KVDAQPMISEEEIAAIATALKIYKGALHDRESEVLTILNIKRAYSPWNSKIHGLTQLPD
                     RR"
     CDS             complement(12066..13631)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_15"
                     /sec_met_domain="CT_Btheta (E-value: 3e-286, bitscore:
                     939.8, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQIQEKINKLIENRETARLGGGQKAIDKQHDKGKYTARERIQML
                     LDEGSFEEFDMFVTHRCYDFGMDRKHTFGDGVVTGYGTIDGRLVYVFAQDFTVTAGSLS
                     LSMSDKICKVMDMAMRNGAPCIGMNDSGGARIQEGVNALAGYANIFQRNVMSSGVIPQI
                     SAIFGPCAGGAVYSPALTDFIIMKKETSNMFLTGPKVVKTVTGEDVTQEQLGGALMHTT
                     KSGVAQFAVDTEEEGIGLIKKLISYMPQNNMEDAPLAVCTDKITRLEDSLNEIIPDSAN
                     KPYDMTEVIKAIVDNGEFLESAAGYAKNIITCFARFNGQSVGIIANQPKFMAGVLDINA
                     SRKAARFVRFCDAFNIPIVTLVDVPGFLPGTTQEYGGVITHGAKLLFAYCEATVPKITV
                     TLRKAYGGAYIVMSSKHIRGDINYAWPTAEIAVMGASGAVEVLYGKELKELADKPEEKA
                     KFIAEKEQEYNDKFSNPYNAARYGYIDDVIEPRNTRFRVIRALQSLATKRLQNPAKKHS
                     NIPL"
     CDS             complement(13636..14046)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_16"
                     /sec_met_domain="Glyoxalase_4 (E-value: 5e-27, bitscore:
                     84.8, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVSHIEHLGVAVKSLDEAIPYWENVLGLKCYAIEEVADQKVRTA
                     FFMLGQTKIELLEPTSEDSTIAKYIENRGVGIHHMALACENIEEQLADAEAKGIRLIDK
                     TPRKGAEGMTIAFLHPKSTQGILTELCENKNK"
     CDS             complement(14257..15246)
                     /locus_tag="ctg63_17"
                     /transl_table=11
                     /translation="MKIGLDTAPAALRGTYFQHLASVLARYAPEHEYIIGAEVNDGVDL
                     YHGFRSSLPLSVHLRRVPSVMTVPNLNFLRYPHLYTFAERLFVLTLYRRALRRAGRVIT
                     VSAPAREELSERLNIDPSKIEVMVPLAVPAPRGNPSQAELEHVRRKYALPEHFILMIGT
                     VEPRHNHQAVFAALADAASPAGVVVCGRRTAWSDYLLGYARARRIAARVDFIYELTPSD
                     LPALFRLARVFAYLPDADAEASVVPVVEALRAGLPMVLSDTQVNREAAGEAAAYVRPEA
                     RGEVLAALENALEDVSWRRTMQERERRRAELFSEYAVAERLMQIYTSL"
     CDS             15318..15782
                     /locus_tag="ctg63_18"
                     /transl_table=11
                     /translation="MKKVLLIWLLAAGFASAGATAQNIALGERVPELKIQTWLDNRQPE
                     PAPTTYIEFFHSTNPACKTSLERLKEITGKSGTKLRVIVVTKEDPAKIAPLLRPYLSER
                     ISVGLNAEKSFTAFGVSYLPFGVLTDAKNRTLWMGNSLQINEKLIEQSTR"
     CDS             15789..16181
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: MeaB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_19"
                     /sec_met_domain="MeaB (E-value: 3e-21, bitscore: 65.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFTRIDHYEKEYADTHHDTALNVTQGVEEQPIVSPYFKRRKKRA
                     LSTGEYVEGILAGNITTLSQAITLVESSNPDHYAQAQEIIEACLPHAGKSVRIGITGVP
                     GAGKSTFIEAIGNMVAGLRHKLAVLAI"
ORIGIN
        1 acctgcgacc tgctgaagga gaactaccgc agcttcgccc tgctgtcgga cctctacaag
       61 cgggtgcagc agctgtgcga cgagcagaac atgatgctcc tctcggaaac caaatacgtc
      121 ctctcggagt tcatcggcca caacgacgcg ccgttcatct acgagaaggt gggcaaccgt
      181 ttcgagcgtt ttatgatcga cgaattccag gacacctccc tgaaggagtg ggaaaacttc
      241 ctgcccctgc tgcaaaacgc catggcgcag tcggaggaga cctcggtgct gatcgtgggc
      301 gacatcaagc agtcgatcta ccgctggcgg ggcggcgact ggaaaatcct ccacggcgag
      361 gcccagcagg cgctgggcgc gggcgacacc caagtcgagg tgctgcggga gaactggcgg
      421 agcctccccg cggtggtcgc cttcaacaac cgcatcatcg aacggatcgt cgccgcggac
      481 aaccgtgcgc tgaacgaaac cctcgcaaag gcctccgagg agggttccgt cgatcccgcg
      541 gaggccgccg cgctgcgcga caccctcgcc gacgcctacc gcggacatgc ccagctcccg
      601 cgccgcaagg ccgaacaccc gggctacgtc tcggtcgaga ccttcgccga gcggccgccc
      661 gtcgtggagc gcatctgcgc gctgatcgac aagagattcc ggccgtgcga cattatgatc
      721 ctcgtgcgcg gggccaccga cggcgcgaag gtcgccgccg aactgctcga cttcaaacgc
      781 cgcaacaaag acccgcgcta ccgtttcgac gtgatgaccc aggaggctct gatcgtgggc
      841 aacgcccccg tcagctcgtt catcgccgcg gccctgcggc tggcgctcaa ccccgacgac
      901 tcgctctcgc gcgccgtcta caaccactac ctcggccgcc cgttcgaccg gccgctcgac
      961 gattcggaac gcgatttttt ccgctcggtg cggctcctgt cgcccgagga ggcgttcgag
     1021 cggatcgtca tgcggcacgc cctgcaaggc gaccgtcggc agacggccta cctccaggcc
     1081 atccacgagc agatcatctc gttctgcgcg acgaaaatcg ccgacatagc gctgttcctc
     1141 cgctggtggg aggagacggg caaaaaccgc tcgctgtcgg tcgaggagag cgccacgacg
     1201 gtcgagatca ccaccatcca caaggccaag gggcttgaaa agcgggccgt gctcatcccc
     1261 tactgctcgt ggtcgccgga ccccaagtcg agcggtacgg tgcagaacat cgtctgggcc
     1321 gaggcgcgcg gcgacggagc cgaagcgatc ggccgcttcc cggtgaagta caagaaggcg
     1381 atggccgaat cgggcttctc gtcggagtac taccgcgagc tggtctacgc ccacgtcgac
     1441 aacgtcaacc tgctgtacgt ggccctcacg cgcgccgccg agtcgctgca cgtcttcatc
     1501 ccgcagaagg gcggccgcac ggtcgggggg ctgctgctcc agagcatcgc aaccgacggc
     1561 gacaaggccc tgctgggcga cttcgaaggc cgctgcacca tcgacgaagc gggcgaacac
     1621 ttcgctttcg gggagttcgc aggccccgtc gcgggcggtt cgaaacgctc cgaggccgag
     1681 cacgtcattc tggaggagta ccccacggcg caggccgacc tgcggctgcg gctcccctcg
     1741 caacgctatt tcgaggacgg cggcgaggtc gagctctcgc cccggaacct cggcatcctg
     1801 atgcacaggg ccttcgagca ggccgacgac gaggccggaa tccacgaggc cgtgcgcggc
     1861 atgcaggccg acggcacgct gtccgaagcc gatgccgcga ccctgcggca gatgatcgcc
     1921 cgggccttgg aacaccccga ggtgcgcgaa tggttcggcg gaggctggga gcgcgtgcgc
     1981 aacgaaaacg aaatcatcat ccccggaaga gggtcgacgc ggcgtcccga ccgcgtgatg
     2041 atcgacggac gccgggtcgt cgtcgtcgac tacaagttcg gcctgcgcga cgccgaacgc
     2101 caccgccggc aaatgcgcga atacctccgc ctgctgggcg aaatgggtta tgccccggcc
     2161 gaggggtatc tgtggtatgt gaaactgggt aaaatcgaaa aagtggagcc atgagaagca
     2221 tcctccgaag ccttcccgcc gcattccgcc gccggggtct ccgcatcgcc gcgaccctcg
     2281 tgctgcgcgc cgtgctgaac ctggcgggac tcgcggccct gctgccggtg ctgacgctgg
     2341 tgctcgaccc cgcgggattc gagggcgacg ggccgctggc gacggtctac gtctggtcgg
     2401 gcgtcgcctc gccgcgcacg ttcgcactcg cggtctgcgg ggccgtcgtg gggttcatcg
     2461 tcctcaaatg cggcgtcaac ttcctgctgg cacgcgccga acgccgctac atctacgacc
     2521 tctaccgcac cctttcgcgc cgcctctaca tcgcctacca cgaccggggt ctggccttca
     2581 tcaacaattc gaactcctcg gtgctggcgc gcaacgtcaa cgtcgtctgc ctggcattcg
     2641 ccgccggggt cctgcgcccc gccgccgcga tgatcgccga ggcgatgctc ttcgtcctgc
     2701 tgttcgcctc gctggctctc tacacgcccc tcgcggcgct gctctccgtc gtgatcttcc
     2761 tccccgcggt gtggctctac tacgcgctgg tccgcaaccg catcaaccgt tacggcgaac
     2821 aggagaaccg cgcccagcgc gagaagtcgc gcctcgtggc cgagaccttc cggggatacg
     2881 ccgacatcga gttgagcgac gccttcccgg ggatgctccg cgccttcgac cgcacgatgg
     2941 acgaagtggt gcgcacccgc tcgcgcgagg ccgacatcgg ccagctgccc caactcttca
     3001 ccgagatcgg gcttgccgtg ggcatggccc tgctggcggc cgtgagcttc ggcggcgggc
     3061 agtcgcagct gctgttcggc gtcttcgccg tggcggccct gcggctgatg ccctccgtgc
     3121 gcggcatcat gtcgggctgg gccacgatcc gctacaaccg ctacaccatc cccatcctgc
     3181 gcgaagcggc cctccacgag ccggcctccg cgcaccccgg ggtcccgacg cgcgaaacgc
     3241 tgcccttcga gcgcgaaatc tcggtccgca acctctcgtt ccgcttcacc gaagagagcc
     3301 gggagctttt ccacggcctc acgctgacca tccgcaaggg cgaacgcatc ggcatccgcg
     3361 gggcgtcggg cgcaggcaag accacccttt tcaacctcct gctgggcctt tacgaaccca
     3421 cgtcgggaga aatcgccgtc gacggcacgc ccctcaccgc cgcaaaccgc cgggcatggc
     3481 agaaccgcat cggctatgtc tcgcagcgtc tgttcctcac cgacggaaca ttcgcggcca
     3541 acgtcgcacc gggcgtcccg gccgccgaaa tcaaccgccg gcgggtcacc gaagccctcg
     3601 aagcggccca gctgggcgaa ttcatcgctt cgctgcccct ggggatcgac acccccgtcg
     3661 gcgaatgcgg cagccgcctc tcgggcggac agcggcagcg catcggcatc gcacgcgccc
     3721 tctaccgccg cgccgacgtg cttttcttcg acgaggcgac ctcggcgctc gacagccgca
     3781 ccgaagggga gatcaaccgt tcgatcgccg cgatcgccgc acggaatccg ggccttacgc
     3841 tgctggtgat cgcccaccgc gaaacctcgc tcgaatactg cgaccgaatc ataacgctgg
     3901 aaaaataaga tgaagaaccg gaagccgtcc cttattccca tctgccagcc gcgacccact
     3961 cccagcgagg gagagggcct acgattcacc cggctcgtac ggcagagtat atccttgcac
     4021 cgccggcgcg aaaaaaaatg aacgctaaca accgctttat gaattatacg atcgccaata
     4081 tccgcgtctc cctgcccgac gcctgcacgg gagagcattt cacccgggcc ctgcgcccgt
     4141 tcctgacact cggcgccggc cctgcggacc tcgcgctgga aatcgtcccc cggattccgg
     4201 ccgaagccga ttaccgcgaa ctcgacatct tcgagtttcc cgacgccgac gccgactgcc
     4261 gtttcgggac cgacgcggcg ggctacctgc tcgaaatgac gccccgcgac ggcagcgccc
     4321 cggcccgcta ccgcatggcc tacggcgcgg cggcggcccg gagcgacatc acccccggac
     4381 acaatcccgc gctgttccgg ttcggggtct ggatcctttt caacatcgcg gcgctgcccc
     4441 tcggagccgt ggccttccac tcctcggtga tcagctaccg cggccgggga gtgctgttcc
     4501 tcggcgaatc gggaacaggc aaaagcaccc acacgcggct gtggcgggag catatcccgg
     4561 gtgcggaact gctcaacgac gacagtccga tcatccgggc cacggacagc gaagccctcg
     4621 tccacggatc gccgtggagc ggcaaaacgc cctgctaccg caacgagagc tgcccgatag
     4681 ccgccgtcgt acggctctcg caagccccgc acaaccgcat ccgccgcctg cggccgatcg
     4741 agtccatcgg agcgttgctc ccctccgcac ccccggcctt cgcccgcgac gaacggcttt
     4801 cggacgacac ctgcggcctg ctctcccggc tgatcgcaca ggttcccgtc taccacctgg
     4861 agtgcctgcc cgacgcggcg gcggcgcagc tcgcctgccg aacggttttc aacgacgcga
     4921 cgctatgatc ctgctcccca accaactctt cttcgccgag gtcgaggcga tgctctccga
     4981 aggccgcgag gttcagatcc gcatgaaggg ccacagcatg cggcccctgc tgcgcagcga
     5041 gcgcgaccag gtcgtgctga cgccctgcac cgaccccgcg cgcctgcgac cgggcgacgt
     5101 ggtgctgttc cgctgctgcg gccgccacat cctccaccgc atcgtccgcc gcgacggcga
     5161 ccgcctcaca ctcgcgggcg acgggaacta ccgcatcacg gaacagtgca cgacacgcga
     5221 cgtcgccggc atcgccgtcc ggatcatccg cgcctcgggc cgcgtcgtcg gctgcgactc
     5281 ccccggctgg cagctccggt cgcgcctctg gctcgcgatc ccgccctggc tgcgacggca
     5341 ggtgctgcgc gtgctctggc attcgggctg gaaatgaaaa aggcagggct ttcgacagcc
     5401 ctgctttttt acggcagccc acggaagaga ccgggagaga aaatccccgg acgggtaacg
     5461 ccggagtgcg tcccgtccgg ggatttcgag ggatgtgcgg aaatatccgc cgtggttcct
     5521 gcggagaacc gcaaatggca acaaaaaaac agaccggatc gctccggtct gttttcacat
     5581 aaatcggcct ggactattcg cccagagcga accgcttgta agccacgacc gtggcatcct
     5641 tgtcggcctt gtggatgtag tcggcgatcg actccttctc gcctaccacc ggctgggcca
     5701 gcagcgtgtt ctcctcgaag aacttgcgca tcttgccttc ggcgatcttc tccagaatgg
     5761 cctcgggttt gttggcgttc ttggggtcct gcttcatggc ctccacggcg atcttgcgct
     5821 cgtgctccac aacctctgcg gggcagtccg cctccgagat cgaaacggga gccatggccg
     5881 tagcctgcat ggtcacggtg tgtgcgacct cggcgggaat ctccttgttg aagcccagga
     5941 tcgtacccag cttcttgttg aagtgcacgt aagcggcgca gtagggagcc tcgatgcggc
     6001 cgtagtaagc cagctcgatc ttctcgcccg tctgacccga tttctcggtc accatctcct
     6061 cgacggtgcg gccctctgcg tttttcgcag ccatcagcgc atcgcggtcg gcagcgtcgt
     6121 tcttcacggc gacctccagc atggcctcgg ccgaagccga atactcggag ttctgggcca
     6181 cgaagtcggt ctcgcacgcc aggcagagga tgtaagcctt ctggcctacg atcttcgtaa
     6241 cgacgacacc ctcggtagcg gtgcggtcgg cgcgcttggc gacgatgagc ttacctttct
     6301 cgcggataat gtcctgagcg cgggcaaaat caccttcggc ttcgatgagg gccttcttgc
     6361 agtccatcat accggcgccg gtcatcttgc ggagcttcat tacatcagca gctttgattt
     6421 ccataatctt gtcctttctc tataaggttc gtaaatacaa ttattctgcc ttttcctcgg
     6481 cggtctcggc tgcttcagca acaacttcgg ctgcttctgc gggagcggca gcaggctcct
     6541 cgtagggagt ctcgacagcg gcgacaacct ctgccacggc agcctcctcg gcatcaatcg
     6601 cagccttcac ggccttcttg atgcggggct tgccctcctt cttaacggtt gcaccctcgg
     6661 cgtcagcctc ctgtgcctcc ttctcctttt cgagcttgcg ctcctcggtg ccctcggcga
     6721 tagcggcgca catggcttcg agaaccacgg cgatcgactt ggtggcatcg tcatttgcag
     6781 ggataacgta atcaatgtcg gtcggatcac aacaagtgtc taccattgca aatacgggga
     6841 tgctgaggcg tttggcctcc ttcacggcgt tggcctcctt ctgtacgtcg acgacgaaca
     6901 gagccgccgg aagacgcgtc aggtcggcga tcgagccgag gttcttctcc agtttcgcac
     6961 gctggcggga gatctggagt ttttcgcgct tggagaaatt atcgaacgtg ccgtcggtcg
     7021 ccatcttgtc gatggtggac attttcttga cggctttacg tatggtgggg aagtttgtca
     7081 gcataccgcc ggcccaacgc tcggtgacgt aaggcatacc gacggctgcc accttttcgg
     7141 caacaatgtc cttggcctgt ttcttggtcg ctacgaacag cacgcggcga ccgctcttgg
     7201 cgatctgctt gatggccgca gcagcctcat cgatcttcag gacggttttg tgcaggtcga
     7261 tgatgtggat gccgttcttc tccatgaaga tgtaaggagc cattttgggg ttccatttgc
     7321 gcttcaggtg accgaagtgc gcaccggctt ccaataatgt attaaaatct gtacgtgaca
     7381 ttttaattca attcgttgat taattttaat tctcttttct tcaaccctcc gggtagcggc
     7441 ctggccggtc ccggggagtt ttccgcggcg cggcaaccag atagtagact aattaaaaat
     7501 taagaattaa aaatgaaaaa ttcccaatat ataataagta tccatgtggt ttgagaaccg
     7561 tcgccgtgcg ttgccgaaat tccggtcgtg cgtattaacg cttgctgaac tggaacttgc
     7621 ggcgtgcacc gggctgaccg ggcttcttac gctcaacctc gcgggaatcg cgcgtgagga
     7681 atccggcctt cttcagcacc ggacgcatct ccgcgtcgat ttcgcacagt gcgcgtgcga
     7741 tgcccagacg agcggccgaa gcctgtcccg taataccacc gccatcgagg ttgatgacga
     7801 tgtcgtaatt ctccgccgtg ttggtggcca gcaggggctg cttcacctgg tactggagaa
     7861 tttcgagcgg gaagtaaact tcaagcgctt tgcggttgat tgtaatctga cccttgcccg
     7921 gcttcacgta tacgcgagcc acagcggcct tacgacgacc tacggtgttt acaacttcca
     7981 taactcttac ttaatctcgt ttaatttaat agtcttcggg ttctgtgcgg cgtgaggatg
     8041 ctctgcgccg gcatagacct tcaggttcga cagcagcttg tcgcccagac gggtcttggg
     8101 cagcatgcct ttgacggcct tctcgatgag gaaggtcggt ttctttgcca gatagtcggc
     8161 aggcgtagcg aaacgctggc cgccggggta tccggtgtga cgcgtgtaga ccttgtcggt
     8221 cattttgttg cccgtgagct tcaccttctc cgcgttgatg acgatgacgt agtcaccaca
     8281 gtcgacgtgg ggtgtgtagc tgggcttgtt cttgcctcgg aggatcttcg cgacctgcga
     8341 tgcaagacgt cccaatacct cgttcgtagc gtcgatcacc acccattcct tggtgacggt
     8401 cgcagcgttc gccgagatag tcttgtagct taatgaatcc actgttttta cgtttaattt
     8461 aacttattgt aatccgttcc ccgcacattg cgggtgcgca aaggtacgaa aaagtttctg
     8521 atctgcaaaa acaaatgaaa atcaaaatcg aaaaccgcgc aaaaaaaccg caacggcccc
     8581 gtattcagga gagttgcggc attccgaagc aggagcgcgg cgttagcggg cgcccttggc
     8641 aggcaggcgg caggcgggcg gctgtgtcaa tacgaacggg atgaaccccg gttccggccg
     8701 gcggcgccgc tcgggaaccg cagttccgag cgaattttga aatcgaccgg cagcgtgtat
     8761 tccacccgga cgagcgcacc gtcctgcctg cccggcgtcc accgcggcgc acgtccaagc
     8821 acgcgagcga ccgcttccga aaattgcgga tgcggcgact cgaggatctc caccatcgta
     8881 atccgcccct ccttgtcgac gacgaatgcc gcgaccacac gcccctgcac gccccgtttc
     8941 agcatgtccg acgggtacct cacttcagcc atcacccaac tccggaattt atccagcccg
     9001 cctccgaaga acttcggcat gacctcgacc acccggtaag cgtctttatc gctgtattcc
     9061 gctccggcgg ccccgggacc gaaggcgacc ggcatcgaga ccccgaaacg aacccgctct
     9121 ccgtcaatcg tcgccggagt ccacgcagga gccgcggcaa tggcctgacg caccgtctgt
     9181 tccaaagcat cctcgtcccg gtatttcggt ttgggggcag gagtcacccg cccgtccttt
     9241 ccgacgacaa accgcaggat cagtttccgc ggctccgtga gcgcacccgg acccatcagg
     9301 ctgtcgacct gccgctgcac ccacgcacga aacccgtccg gaccgcgccg cagaacaggg
     9361 gcatcctatc ggccgtcgta tggatgtcgc actcctcggc gcaaagcccc agctcctcct
     9421 gtcccgcagg aggggcgacc agccggaaga cgaatcgcat ctccagctcc gtttttacag
     9481 gtttcccctt cgtccgtccg ggcgaccatt tcggcgacag ggcgatcgtc ttgcagagcc
     9541 ggtcggcaaa atgccgctcc tcgcaatgcg tgaccttcag atcggtcagc gtcccgtttt
     9601 tgtcgatggc gaacacaact tcaaccttcg cctcatcccc gacatcgtag cgatcggccg
     9661 gaaaccgcag gttgcggatc acccagattt tgaagcattc cggacggctt ccctgaaaag
     9721 aggggtccat cttttcgggc caaaggctgg ccgccgcacc ggcgtttttt ccgggggtct
     9781 tttcctctcc ggcggttttc gcggcggtcg cagccgcatg cagcgacgca aggccgaaaa
     9841 gcaccataaa caagcgtttc ataataaggc aggagtttta ggtttcataa atatagcgaa
     9901 aaatgcgaga cttgcaacgg cacaggcgca aaaaagaggg tccggcgaac cgaaaccctc
     9961 ttgcaaccgt atcgggccgt gcggcccgga acgcgattcc ctatccgagg aacgaaagca
    10021 gaatgcccgc ggcgaccgcc gaaccgacca cgccggccac gttgggaccc atggcgtgca
    10081 tcagcaggaa gttcgaggga tcggccttct ggccctcggt ctgcgacacg cgggcggcca
    10141 tcgggacggc cgaaacgccg gccgaaccga tcagcggatt gatcttgttg tcgcccttcg
    10201 agaagaagtt catcaccttg gcgagcagca cgccgccggc ggttcccatc gcgaaggcga
    10261 tcacgcccag cacgaggatg aacagcgtcc gcggattgag gaacgcctcg gccgtagccg
    10321 tagctcccac cgtgagaccc aggaagatga cgacaatgtt catcagttcg ttctgcaccg
    10381 tcttcgacag acggtccacc acgccgcact ccttcatcag gttgcccagc atgagacagc
    10441 cgacgagcgg agcggccgac ggcagcagca gcgcgatgat cacggtgatg atcagcggga
    10501 agaggatctt ctcggtcttc gacaccggac gcagctggcg catcttgatc ttacgctcct
    10561 tctcggtggt cagcatgcgc atgatcggcg gctggatcac cggcacgagg gccatgtagg
    10621 agtaggcggc cacggcgatc gggccgagca gctcgggagc cagaatcgcg gtcaggtaga
    10681 tcgacgtggg accgtcggcg ccgccgatga tgccgatcga accggcctcg gctggcgaga
    10741 atccgagcgc ataagcgccg atgaacgtga ggaaaatacc aagctgcgcc gcggctccca
    10801 gcaggaagct cttggggttg gcgatcaacg ggccgaagtc ggtcatggcg cccacgccca
    10861 cgaagataag gcagggatag atgccgagct tcacgcccag atagaggtaa tcgaggagtc
    10921 ccgcctgggc gacgaaaata tcccagtgga cgtgcccccc ggcaaaaagt tccgtatggt
    10981 agaggttcgc tccgggaagg ttcgtcagca gcatgccgaa cgcgatggtc agcagcagca
    11041 gcggttcgaa cttatgtttg atggccaggt acagcagaaa gaaggccaca cagatcataa
    11101 tcagactgcc ccaccccatg ttggctatca gaccggccac gcccgtcgat tcggcaaagg
    11161 tttcaaggct ttccagcacg aaattggagc tggaagtcaa tgcattccac atagtcctac
    11221 ccgattacga ttaaaacgtc gccttccatg accgtagcgc cctgctgcac gagaatctgc
    11281 ttcacgacac cggcgcggtc ggcgtcgatg ttgttctcca tcttcatggc ttcgagcacg
    11341 acgagcgtct gtcctgccgc gacggtatcg cccacggcca ccttcacgct caacacggtg
    11401 cccggcagcg ggcatttcac gctggaaccc gacgtcgaag gcgcgggagc gatgcgcggc
    11461 gaaggagtgg ccgtcgaggg agtgatcatg gcgctgttgg ccgacttggg ggccggggac
    11521 acctggggtt tggagaccgt cgaggctttc gcgccctcga tctcgacttc gtaatccacg
    11581 ccgttgacca cgacgtgcgc taccgtcgag gcctcgttca cgtcgtcgat ctggacgttg
    11641 taattatgtc cgttgatttt caaagagtaa tctttcattt tcttttttgg gttgtcttgt
    11701 tccgacgcag ggtcctatct ccggtcggga agctgggtta aaccgtgaat tttcgaattc
    11761 cagggcgaat aggcccgctt gatgttgaga atggtcagca cctcggactc gcggtcgtgc
    11821 agggcgccct tgtagatctt gagcgccgta gcgatggctg cgatctcctc ctcgctgatc
    11881 atcggctggg cgtcgacctt cctgccgctc gccggacgga cccggaagca ggccccgaag
    11941 gccttcataa tgaagatcag cgccactagc aggataaaca ccaggctgaa cccgatcagc
    12001 gacacccaga gtatctcgga ccatccccag ttcataactg tcagtattgt catcttttca
    12061 gtctgttaga gaggaatgtt cgaatgtttc ttcgcggggt tctgcaaacg cttcgtagcc
    12121 agcgactgca aggcgcggat cacacggaaa cgcgtgttgc gcggctcgat cacgtcgtcg
    12181 atatagccgt agcgtgcggc gttgtagggg ttggagaact tgtcgttgta ctcctgctcc
    12241 ttctcggcga tgaacttcgc cttctcctcc ggtttgtcgg ccagctcctt cagctccttg
    12301 ccgtagagca cctcgacggc gccgctggcg cccatcacgg cgatctcggc cgtcggccat
    12361 gcgtagttga tgtcgccgcg gatgtgcttc gacgacatga cgatgtatgc gcctccgtaa
    12421 gccttgcgca gcgtcacagt gatcttcggc acggtggcct cgcagtaggc gaacagcagc
    12481 ttcgcgccgt gggtgatcac gccgccgtac tcctgggtcg tacccggcag gaagcccgga
    12541 acgtccacca gcgtcacgat cgggatgttg aacgcgtcgc agaaacgcac gaagcgcgca
    12601 gccttgcggc tggcgttgat gtccagcacg ccggccatga acttgggctg gttggcgatg
    12661 atgcccaccg actggccgtt gaaacgcgcg aagcaggtga tgatgttctt ggcatagcct
    12721 gcggccgatt cgaggaactc gccgttgtcg acgatggcct tgatcacctc ggtcatgtcg
    12781 tagggcttgt tggcgctgtc gggaatgatc tcgttgagcg aatcctccag acgggtgatc
    12841 ttatcggtgc agacggccag cggagcgtcc tccatgttgt tctgcggcat gtaggagatc
    12901 agcttcttga tcagcccgat accctcctcc tcggtgtcga cggcgaactg cgccacgccc
    12961 gacttggtgg tgtgcatcag ggcgccgccc agctgctcct gcgtcacgtc ctcgcccgtc
    13021 acggtcttca cgaccttcgg gccggtgagg aacatgttcg aggtctcctt cttcataatg
    13081 atgaagtcgg tcagcgcggg cgaatagacc gcaccgcctg cgcaggggcc gaagatggcc
    13141 gaaatctgcg gaatgacgcc cgacgacatc acgttgcgct ggaagatgtt ggcgtaaccg
    13201 gccagggcgt tgacgccctc ctggatacgc gcgccgcccg agtcgttcat gccgatgcag
    13261 ggcgcgccgt tgcgcatggc catgtccatc accttgcaga tcttgtcgga catcgacagc
    13321 gacagcgaac cggccgtcac ggtgaaatcc tgtgcgaaga cataaaccag acgtccgtcg
    13381 atcgtgccgt aacccgtcac cacgccgtcg ccgaaggtgt gcttgcgatc catgccgaaa
    13441 tcgtagcagc ggtgggtcac aaacatatcg aactcctcga acgaaccttc gtcgaggagc
    13501 atctgaatac gctcgcgggc cgtgtacttg cccttatcgt gctgtttgtc gatcgccttc
    13561 tggccgccgc cgagacgcgc ggtttcgcgg ttctcgatca gtttgttgat cttttcctgt
    13621 atctggctca taatcctatt tgtttttgtt ttcgcaaagc tccgtcagaa tgccctgggt
    13681 cgatttcggg tgcaggaagg cgatggtcat gccctcggcg cccttgcggg gggtcttgtc
    13741 gatcagacgg atgcccttgg cctccgcgtc ggcgagctgc tcctcgatgt tttcgcaggc
    13801 cagcgccatg tggtgaatgc cgacgccgcg gttctcgatg tactttgcga tcgtcgaatc
    13861 ctccgaagtc ggctccagca attcgatctt ggtctgcccc agcatgaaga acgccgtgcg
    13921 gaccttctgg tcggcgacct cctcgatggc atagcacttc aggcccaata cgttctccca
    13981 gtagggaatc gcctcgtcga gactcttcac ggcaacgcca agatgctcga tatgagaaac
    14041 tttcatagca aaatttaaat ttaagttagt ggatattcgt atgttgtttc gttcgttgtt
    14101 attttgcgaa cacaaagata gacgaatctt tcagaaccgc caaaattcgg agtacttttt
    14161 ttggcaataa cttcgggttc ggaattcgca ggaaatgtcc ggaaaggcga ttcgttccgg
    14221 cggagcctcc ggcggcctgc ggtttgaaag ccggggttac agcgacgtgt aaatctgcat
    14281 cagccgttcc gccacggcgt attcggagaa cagttcggcg cggcggcgtt cgcgctcctg
    14341 catcgtgcgg cgccacgaca cgtcttccaa cgcgttttcg agcgccgcga gaacctcgcc
    14401 ccgcgcctcc ggacgcacat aggcggcggc ctctccggcg gcttcgcgat tgacctgcgt
    14461 gtcgctcaag accatcggca aacccgcccg cagggcctcg accacgggga cgaccgacgc
    14521 ctcggcatcg gcgtcgggca gataggcgaa gacccgcgcc agacggaaca gcgccggaag
    14581 gtccgaaggg gtcagttcgt agatgaaatc cacccgtgcg gcgatgcggc gggcgcgggc
    14641 atagcccagc agatagtcgg accaggccgt gcggcggccg cagacgacca ccccggccgg
    14701 ggacgcagcg tcggccagag ccgcgaaaac cgcctgatgg ttgtgccgcg gctcgacggt
    14761 ccctatcatc aatataaaat gctctggaag agcatacttg cggcgcacgt gttcaagttc
    14821 cgcttgagat ggatttccgc gcggagccgg aaccgccagc ggcaccatga cctcgatctt
    14881 cgaagggtcg atattgaggc gttccgacag ctcctcgcgg gccggagcgc tgaccgtgat
    14941 gacccggccc gcccgccgga gcgcacggcg gtagagcgtc aggacgaaaa gccgttcggc
    15001 aaacgtatag agatgcggat agcgcaggaa attgagattc gggaccgtca tcaccgaagg
    15061 cacgcgccgc agatgcacgg acaacggcag cgacgaccta aagccgtggt agaggtcaac
    15121 accatcattc acctctgcgc caatgatata ttcatgctcc ggagcgtagc gcgccagcac
    15181 gctggcgagg tgctggaagt aagtcccgcg gagtgcggcg ggagccgtgt cgagtcctat
    15241 tttcataact tgattctaaa aaattggtcc atatgccaaa taattgttat ctttatcgaa
    15301 taaaacaagg ctctcttatg aagaaagtgc tgcttatatg gctgttggcc gcaggtttcg
    15361 catccgcggg agccacggcc cagaacatcg ccctcggcga acgcgttccc gaactcaaaa
    15421 tccagacgtg gctcgacaac cgccagcccg aaccggcccc gacgacctac atcgaatttt
    15481 tccattcgac gaatcccgcg tgcaaaacct cgctcgaacg cctgaaggaa atcacgggca
    15541 aatcgggtac caaactgcgc gtgatcgtcg tgacgaagga ggaccccgcg aaaatagccc
    15601 cgctgctgcg cccctacctc tcggaacgga tctccgtggg cctcaacgcc gaaaagagtt
    15661 tcacggcgtt cggcgtcagc tacctgccgt tcggcgtgct gaccgacgcc aagaaccgca
    15721 ccctctggat gggcaattcc ctgcaaatca acgaaaaact gatcgaacaa tcaacacgct
    15781 gacacaccat gtcgttcacc aggatagacc attacgaaaa agagtacgca gacacgcatc
    15841 acgacacagc cctcaacgtc acgcaaggcg ttgaagaaca accgatagta agcccttact
    15901 tcaagcggcg caagaagcgc gcgctctcca ccggagagta cgtcgagggc attctcgcgg
    15961 gcaacatcac caccctctcg caggccatca cgctcgtcga atcgtcgaac cccgaccact
    16021 atgcacaggc gcaggagatc atcgaagcgt gcctcccgca cgccggaaaa tcggtccgca
    16081 tcggcatcac gggcgtcccg ggagccggca aatcgacctt catcgaggcc atcggcaaca
    16141 tggtcgcggg gctgcgccac aagctggcgg tgctggccat ag
//
