LOCUS       c00032_gnlPro..        13441 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FNPCBABE_32.
ACCESSION   c00032_gnlPro..
VERSION     c00032_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 21:11:43
            Original ID  :: gnl|Prokka|FNPCBABE_32
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 8228
            Orig. end    :: 21669
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13441
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[18228:21456]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13228
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13441
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13441
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             182..1306
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_11"
                     /sec_met_domain="Peptidase_S11 (E-value: 7.4e-59, bitscore:
                     189.5, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIILLAVCFVMPFVLMGAKTAEDTPPTTSAQAFVLYCPDNNTV
                     ICSKNADEKMKPASTTKIMTSLITLDEAASCNSEVTFKQEMVAEGSSMYLKVGEKVRLS
                     DLASGMMMASGNDAANAAAYTISGSPEKFSQRMNEKAKQIGMTNTNFVTPSGLDDDNHY
                     SSAKDMALLMSYALENDDFANLTAKKSVTVEFLEPKSKKTAYANHNRLLSLYPYCTGGK
                     TGYTTAAGRCLVSSAKKDGVTLVCVTLNDRNDWNDHISLYDYAFEKYRGVDCKDADFCA
                     DIPCVGGDKDSVTVTGEKNNTIVLKREDCDKIKKKIFIDSFLYAPIEKNESVGRIEYTL
                     GGKLLYKCNIVAGEKIKSDKKSVSIFSAIGNLFS"
     CDS             1350..2099
                     /locus_tag="ctg32_12"
                     /transl_table=11
                     /translation="MAKIEPIRLQKFIAQCGIASRRKAEELILGGHVKVNGKTAILGDK
                     VLPTDKVFVRGKRIVVPKGGNYRYIMLNKPRGFITTMNDERGRKCVAQLVENVGERVYP
                     IGRLDKDSEGMLVFTNDGDFANKVMHPKNNVYKIYRVTVRPSIDEDQLVKLETGVELDG
                     RKTAPAYVHVIHKEQGRVVLEMILHEGKNREIRRMCEAVGLEVARLKRTQIGGVKMGML
                     KQGDWRDLTEQEVKKLLANPFLNGKQL"
     CDS             2309..3643
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CT_Vparvula"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_13"
                     /sec_met_domain="CT_Vparvula (E-value: 1.8e-76, bitscore:
                     248.1, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLEDFKMSIEKINQAKAEIAATSAYKTITAFFDADSFCEIDAFA
                     KSGEGFAEVVAGFGTVEGMPVYAFAQNSDICGGAMSKAQAAKLKKLYGLALKTGAPVVG
                     FYDSVGGRLNQGTELLAGCGDVLNAAASLSGVVPQISVVLGTCLGTNALNAASADIVIM
                     SKDAQLSLSVTGKHSDAAYNAENGIASIVCDDADKAIKAAKELILYLPSNNLTMAPQSF
                     EEAPAEDGCGCVVSRTVDGNSIVKLFNDYGKEANVRFARLGGQVVGIVVTKGKELGCKS
                     ANKVAKFVRFCDAFSLPVVTFVNCPGFESIKSATKASAAYAEATTVKISVVTGKAIGSG
                     YVALAGTGANADVVYALPDAVISPVNVEAAAFIMAPEVMNVATDKQVEVAQKFADENLS
                     AYNAAQNGYVDGIVEEAQLRQTLISALDMLSGKRVSTLSKKHSTI"
     CDS             3682..4047
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 65.7; E-value:
                     8.2e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_14"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.8e-21, bitscore:
                     65.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLRITVNGTAYDVQVEELGGSSAPAAAAPAPAAAPAPAAKPAA
                     PAGAQGSVVVKAPMPGTVVNVVVSAGQAVKAGDDLVFIEAMKMETPVKAPQDGTVATVD
                     VAKGESVDSGKVLVTLN"
     CDS             4078..5481
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PYC_OADA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_15"
                     /sec_met_domain="HMGL-like (E-value: 1.3e-49, bitscore:
                     159.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 1.1e-55, bitscore:
                     178.9, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKIRVTETALRDAHQSLIATRMTTEEMLPVLEKLDKIGYYSLE
                     CWGGATYDSCLRFLNEDPWDRLRTIREHCPNTKLQMLFRGQNMLGYRHYADDCVEYLVQ
                     RSIANGIDIIRIFDALNDIKNLKTAIKAANKEGGHAQVAISYTTGPVFTDEYYVEYAKR
                     IADAGADSICIKDMAALLTPTRTESLVKAIKAAVPELPLQLHTHYTSGLASMCLLKGVE
                     AGADGIDTAISPLALGTSHAPTESMVAALSGTEFDTGLDLKQFSDIRAYFMTLREKYIK
                     SGLLDPKMLATDANALIYQVPGGMLSNLLSQLKQAGKEDKLDEVLAEVPRVRKDSGYPP
                     LVTPTSQIVGTQAVFNVITGKRYSMCTNEFKGLVAGEYGTTPMPIDPEFQKKIIGDKKI
                     IKGRPADQLEPELDKLRGEIEQWIEQPEDVLSYAQFPKVALDFFEKRRNAKVGINGDKL
                     DKKNMVHPV"
     CDS             5676..7013
                     /locus_tag="ctg32_16"
                     /transl_table=11
                     /translation="MKKFLTALIAFVMCFSVVTTAFAATPDEASDSDLISDIKQAMLDT
                     YYGDEKPEYLNVEILLDDEDEVYFSFSDSFATSANRVYTEAGNYIVSYLENCPVALYKN
                     NRVYMIPDAYNSGVIDDDTLEGLTYCGHMDIVPKSDDSALVIEIKNKVIEECFDGKSPE
                     TLRIDIVGRTSDGGVYYRHEYGFALGVIIEEKFGDCTYSYTHGNDVMLYKNNSVYSIKN
                     AYESGIIDDKIVNELVKMNIGIIPDKDVSTLKQLTLKMCQNAGCTDLAEDDIDIWRIIY
                     LSDDRIMFTFNVSGADIPESPVKEVIGNYTFIGEQQLYIYADGQIYTLKEAFDAGIIDN
                     DDLAFFADDWKDDIGFSIVLNPTQPDTTAPTTSTATPDEPATSPAATSATKPVSTSDTA
                     TNDTLSNSQNNSGAVQTGQNSVAVILLVAMLAGCAVIFAKRRNHFE"
     CDS             8354..9613
                     /locus_tag="ctg32_17"
                     /transl_table=11
                     /translation="LSGYDPVGMSAKYVATPKISKTEVTYDGVKLTWNKVAGAEKYRVY
                     YKDGEGWNKLADTTGNSYLDMGLVSRELSIKDNSVNGQYIYTVRCISSNGKVFQSGYDT
                     KGSKANLGNECPEIVRVDSMHGGITVSWTDVCEDNSKYRIYVKEKGSWKKLADTTNNYY
                     THKNVKAGQTYTYTVRCVSKDGKKFTSIYNPSGVTFKYKTTDKTRDAYIDYLLKHESEW
                     LPELKVGNVALAGVQFADLDFDGVPELIVQEAGDKEYYLNAKVYTFKDGKFSLVGFDDY
                     RTYIPNQLTYFYDKSAKKYIINAVELSTSNVDRYLERENYTLNYDGTVLVVRGYSSAHL
                     ALESRGLEYHYYNNTGRTTKQAYNATNVSVLGNCVNAHMYSQFVHCSVDGYPKLWNNYS
                     ETQKKQNLLDSYNAFSYDKY"
     CDS             9676..9930
                     /locus_tag="ctg32_18"
                     /transl_table=11
                     /translation="LRNKNGLAKLTEPLICTMSRLETSSCKLSQTTYTNCERGTRKKGS
                     LKIITMLSSGTSSCKLSQTTYTNYERGTRKKGSLKIKLP"
     CDS             complement(10001..11041)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_19"
                     /sec_met_domain="IlvN (E-value: 1.3e-83, bitscore: 269.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1e-60, bitscore: 194.7,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLK
                     DSGCDVIIGLYKGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKLAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(11102..11593)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_20"
                     /sec_met_domain="ALS_ss_C (E-value: 2.8e-30, bitscore:
                     94.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQDPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRINTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             complement(11606..13228)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_21"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.7e-42, bitscore:
                     135.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKVYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETIKTWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENII
                     KGIVDLEKPFILVCDVHPDTPSI"
ORIGIN
        1 aggtacagcc gacaagctcg ttaatatgat tcccgatgtt cttaaaaaag taaagggagt
       61 tttcaaaaag gataagagcg aatccgcaga cgatttttcc gaaatcacac aggacgatat
      121 tgacggctga ttcgtaatat tgcaacaccc ctcggcatag atttatgcag ggggtgtcct
      181 tatgaaaaaa ataatcttgc ttgcggtgtg ctttgttatg ccgtttgtgc ttatgggcgc
      241 aaaaactgcg gaggatactc ctcccacaac ttctgcacag gcatttgttc tttattgtcc
      301 cgataacaac acggttatct gttccaagaa tgcagatgaa aagatgaaac ctgcgagtac
      361 cacaaagatt atgacatctc tcataacgct tgatgaggcg gcatcctgta acagcgaagt
      421 aaccttcaaa caggaaatgg ttgccgaggg cagttcgatg tatcttaaag tcggtgaaaa
      481 agtccgactt tcggaccttg cgtcaggaat gatgatggcg tcgggtaatg atgcggcgaa
      541 tgcggcggca tatacgattt cgggcagtcc tgaaaagttt tcacaacgaa tgaatgaaaa
      601 ggcaaagcaa atcggtatga cgaataccaa ttttgtaacg ccgagcggac ttgacgatga
      661 caaccattac tcaagtgcaa aggatatggc tttgcttatg tcatatgcac ttgaaaatga
      721 cgatttcgca aatcttacgg ctaagaagag cgtgactgtt gaattccttg aaccgaaatc
      781 aaagaaaacc gcatatgcaa atcataacag gcttttgtcg ctttatccct actgtacagg
      841 cggaaaaaca ggctatacaa cggcggcagg gcggtgcctt gtttcctctg caaaaaaaga
      901 cggtgtaacg cttgtgtgcg tcactctgaa tgaccgtaac gattggaatg accatatttc
      961 tctttatgat tacgcttttg aaaagtacag gggagttgac tgcaaggacg ctgacttttg
     1021 tgccgatatt ccgtgcgtgg gcggtgataa ggacagcgta actgttacag gggagaagaa
     1081 caacacaatc gttttaaagc gtgaggactg cgataaaatc aagaaaaaaa tcttcataga
     1141 cagctttttg tatgctccga ttgaaaagaa cgaatcggtc ggcagaattg aatacacact
     1201 cggcggaaag ctgctttata aatgcaacat tgttgcaggc gaaaagatta aatcggataa
     1261 aaagagtgtg tcaatatttt cggcaatagg aaatctgttt tcgtgacagc ttaaatatac
     1321 agaaaatttt attaaaaagg aatttacata tggctaaaat tgaacctata agacttcaga
     1381 aattcatagc gcaatgcggt attgcgtcaa ggcgaaaggc cgaggagctt attctcggcg
     1441 gtcatgtcaa ggtgaacggc aaaaccgcaa ttctcggcga taaggttctt cctacagaca
     1501 aggtgtttgt aagaggcaag agaattgttg taccgaaggg tggtaattac cgatatatta
     1561 tgctcaacaa gccccgtgga ttcattacca caatgaatga tgagcgtggc agaaagtgtg
     1621 ttgcacagct tgttgagaat gtcggcgagc gagtttatcc gataggcaga cttgacaaag
     1681 acagcgaggg tatgcttgtt tttacaaatg acggtgactt tgcaaacaag gttatgcacc
     1741 cgaaaaacaa tgtttacaag atttacagag taaccgttcg accgtcaatt gacgaggatc
     1801 agcttgtaaa gcttgaaaca ggcgttgagc ttgacggcag gaaaaccgct cctgcatatg
     1861 tccatgtaat tcacaaggag cagggcagag tagttcttga aatgattctt cacgagggta
     1921 agaaccgtga aatcagaaga atgtgcgagg ctgtcgggct tgaggttgca agactcaaac
     1981 gcacccagat cggcggagta aaaatgggta tgctcaaaca gggcgactgg agagatttga
     2041 ccgaacaaga ggttaaaaaa ctgcttgcaa acccgttttt aaacggcaaa cagctttaat
     2101 tttccgtttt tgaaaaatac ttccgaaacg gtcaataaaa ctattcgtta attcgacaat
     2161 aaatttacgg ttttggtgta ataactatta aatgtgttca aaattgaaat agtacagcgt
     2221 gtttttcttg tacttttgaa gattatagag tataatgtat tgtgtagaaa attagtatgc
     2281 acgctcagtt ttcgtgcata ttcaatacat ggtattggag gattttaaga tgagtattga
     2341 aaagatcaat caggcaaagg ctgaaattgc cgcaacttcc gcttataaga caattacggc
     2401 gttttttgat gcagacagct tttgtgaaat tgatgccttt gcaaaatccg gtgaaggttt
     2461 tgccgaggtt gttgcaggct ttggaacagt agaaggtatg cctgtttatg cgtttgcaca
     2521 gaacagcgac atttgcggcg gtgccatgag taaggcacag gctgccaagc ttaaaaagct
     2581 gtatggtctt gcactcaaga caggcgctcc tgttgtaggc ttctatgaca gcgttggcgg
     2641 cagacttaat cagggtacag agcttctcgc aggttgcggt gatgttctca atgcggctgc
     2701 gtcactttcc ggtgttgtac cgcagatctc ggttgttctc ggcacttgcc tcggaacaaa
     2761 cgctcttaac gccgcaagcg cagacatcgt tatcatgagc aaagacgcac agctttcact
     2821 ttcggtaaca ggcaagcatt ccgatgccgc ttacaatgct gaaaacggta ttgcctcaat
     2881 cgtttgtgac gacgcagaca aggcaatcaa ggctgcaaag gaacttatcc tttatcttcc
     2941 gtcaaataac ctcacaatgg ctcctcagtc atttgaagaa gctcctgcag aggacggttg
     3001 cggttgtgta gtcagcagaa ctgttgacgg caacagcatt gtaaagctct tcaatgatta
     3061 cggcaaggaa gcaaatgttc gttttgcaag actcggcggt caggttgtag gtattgttgt
     3121 tacaaagggc aaggagcttg gttgcaagtc tgcaaacaag gtagcaaagt ttgttcgttt
     3181 ctgcgacgct ttctcactcc ctgttgtaac attcgtaaac tgcccgggtt ttgagtcaat
     3241 caagtcggca acaaaggcgt cagccgctta tgctgaggca acaacagtta agatttctgt
     3301 tgttacaggc aaggcaatcg gttcaggcta tgttgctctt gcaggcacag gcgctaatgc
     3361 agatgttgtt tacgcacttc ccgatgcggt tatttcacct gttaatgttg aggctgccgc
     3421 attcattatg gctcccgaag ttatgaatgt tgccacagat aagcaggttg aggttgctca
     3481 gaagtttgct gacgagaatc tttctgctta caatgccgct cagaacggct atgttgacgg
     3541 tattgttgaa gaagctcagc tccgtcagac tcttatttct gctcttgata tgctctcggg
     3601 caagcgtgtt tcaacacttt caaagaagca ttcaactatc tgataaatga ttacttgtta
     3661 aaataaaagg ggatactaaa aatgaagaat ttaagaatta cagttaacgg cacagcatat
     3721 gatgttcagg ttgaagaact cggtggctct tcagctcccg cagcagccgc tcctgctccg
     3781 gcagccgctc ccgctcctgc agcaaagccg gcagctcccg caggcgctca gggttctgtt
     3841 gttgtaaagg ctcctatgcc cggtacagtt gttaatgttg ttgtttcggc aggacaggct
     3901 gttaaggccg gagatgacct cgtattcatc gaggctatga agatggaaac tcccgttaag
     3961 gctccgcagg atggcacagt tgcaacagtt gatgttgcaa agggtgagtc tgttgactca
     4021 ggtaaggttc tcgtaacact taactaatca ataattcgga gaaagggatg ctgtaaaatg
     4081 gcaaaaaaaa tcagagttac cgaaactgct ctgcgtgacg ctcatcagtc actcattgca
     4141 acaagaatga caacagagga aatgctccct gttcttgaaa aactcgataa aatcggttat
     4201 tactcactcg aatgctgggg cggtgcaaca tatgactcat gcctcagatt cttaaacgaa
     4261 gatccgtggg acagactccg cacaatcaga gagcattgcc ctaacacaaa gctccagatg
     4321 cttttcagag gacagaatat gctcggttat cgtcactatg ccgatgactg cgttgagtac
     4381 cttgttcagc gttcaatcgc aaacggtatt gacattatcc gtatttttga tgctcttaac
     4441 gacatcaaga atcttaaaac agctatcaag gccgctaaca aagagggcgg tcatgcacag
     4501 gttgctatca gctacacaac aggtcctgta ttcacagatg aatactatgt tgagtatgct
     4561 aagagaattg cagacgcagg tgcagattca atctgtatca aggatatggc tgctcttctt
     4621 actccgacaa gaaccgaaag ccttgtaaag gctatcaaag ccgctgttcc ggagcttccg
     4681 cttcagctcc acacccacta cacatcaggt cttgcatcaa tgtgtctttt aaagggcgtt
     4741 gaggcaggtg ctgacggcat tgacacagca atcagcccac tcgctctcgg tacatcacac
     4801 gcacctacag agtcaatggt tgccgctctt tcaggcacag agttcgacac aggtcttgac
     4861 cttaaacagt tctctgacat tcgtgcttac ttcatgactc tccgtgagaa gtacatcaag
     4921 tcaggacttc ttgatcctaa gatgctcgca acagacgcta acgctcttat ctatcaggtt
     4981 cccggcggta tgctttccaa ccttctttca cagctcaagc aggccggtaa agaagacaag
     5041 cttgacgaag ttcttgcaga agtaccccgt gttcgtaagg attcaggtta tcctccgctt
     5101 gttactccga cctcacagat tgtcggcaca caggctgtat tcaatgtaat cacaggcaag
     5161 cgctactcaa tgtgcacaaa cgagttcaag ggacttgttg ccggtgagta cggtacaact
     5221 ccaatgccga ttgatcctga gtttcagaag aagattatcg gtgacaagaa gattatcaaa
     5281 ggtcgtcctg cagatcagct tgagcctgag cttgataagc tccgtggcga gattgagcag
     5341 tggattgaac agcctgagga tgttctttct tatgcacagt tcccgaaggt tgctctcgac
     5401 ttctttgaaa agagaagaaa tgccaaggtt ggcatcaacg gcgacaagct tgacaagaaa
     5461 aatatggttc acccagtttg atttgacaac aaaaattaac atttatgcca ctttcgctat
     5521 gaaagtggca ttttcatttg agcagaatta ttttatgtga atttttagca actatattgc
     5581 attacatata ttttagcagt ataatgaagt aaattgaata tctgttgcgt ataccattat
     5641 tacagataga ataaataaaa gatgaggaaa tcaaaatgaa aaaattttta acagcattga
     5701 tagcatttgt aatgtgcttt tcggttgtaa caacagcttt tgcggctaca cctgatgaag
     5761 cttctgattc agacttgatt tcagatatta aacaggctat gttagataca tattatggtg
     5821 atgaaaagcc tgaatatctg aatgtcgaaa ttcttttgga cgatgaagac gaggtttatt
     5881 tcagtttttc tgacagcttt gctacttctg caaacagagt ttacaccgag gcaggcaatt
     5941 acatagtttc ttacctcgaa aattgtcctg tggcactgta caaaaacaac agggtttata
     6001 tgatccccga tgcttataat tcaggcgtta ttgatgacga tacacttgag ggtttgacct
     6061 attgcggaca tatggatata gttccgaaaa gcgatgattc agcacttgtt atcgaaataa
     6121 aaaacaaagt tattgaagag tgttttgacg gcaaatcacc tgaaactttg agaattgata
     6181 ttgttggcag aacaagtgac ggcggagtat attatagaca tgaatacggc tttgcacttg
     6241 gtgttataat tgaagaaaaa tttggtgatt gtacatatag ttatacacac ggaaacgatg
     6301 ttatgctcta taagaataac agtgtttatt caattaaaaa tgcgtatgag agcggaatca
     6361 ttgatgataa aattgtcaat gagttagtaa aaatgaatat tggtattatt cctgataaag
     6421 atgtaagtac acttaagcag ttaaccttga aaatgtgtca aaatgcaggt tgtactgatt
     6481 tggcggaaga tgatattgat atatggagaa ttatctattt aagtgatgac cgaataatgt
     6541 tcacttttaa tgtatccggt gctgatattc ccgagagtcc tgtaaaagag gttatcggaa
     6601 actatacatt tataggtgag caacagttgt atatttatgc tgacggtcaa atttacacat
     6661 taaaagaagc ttttgatgcg ggcataattg ataatgatga cttggcattc tttgctgatg
     6721 attggaaaga tgatattggt ttcagtattg tccttaatcc gacacagcct gatacaacag
     6781 ctccgacaac atcaacggca acacctgatg aacctgctac atcacctgcc gcaacttcgg
     6841 caactaagcc tgtttcaaca agcgacacag ctacaaatga cacactgagc aattcacaga
     6901 ataacagcgg tgcagttcaa acaggacaga acagcgttgc tgtaattctt cttgttgcaa
     6961 tgcttgcagg ttgtgcagta atttttgcaa aacgcagaaa tcattttgag taatttacaa
     7021 attaaataac ccctataaaa gccgttctcg ttattgagag cggtttattt attttagctt
     7081 aaaaaatttg tgatagttta tcaagatgta ttgcttttta tatcatttaa tgttacaatt
     7141 aacttgcata aaaatttagc gaaagttctt aataatgcgt agaatattta caaagcgagg
     7201 gatagatatg aaaaagtttt tacctatagc catggcggcg gtaatgtcga tgtctgcggt
     7261 tgcggtttcg gcagtttctg caaatgcggt tgaaccgcta aacacacccg tgcagtatgc
     7321 acaggttgca agggcaagct tggcaactcc gaaaatttca aaagccgaaa gcgtttacgg
     7381 cggtgtaaag cttacatgga acaaagtgaa cggtgcggct aaatacagag tttactacaa
     7441 gggccgtaaa ggctggacac gaatggtcga tacaacttca acatcatata tcgacaagga
     7501 tgtttcatct ggcaggaatt acacctatac tgtaagatgt atttctgctg acggaaagag
     7561 ctttacaagc ggttatgatt caaaggggac aactgtaaaa tatgttgctg ctcccgaaat
     7621 ttcaaagctt gaaaatgtaa acggcggtgt aaaaatctct tggggtaaag taagcggtgc
     7681 gactaaatac agagtttact acaagggccg taaaggttgg acacgaatgg tcgatacaac
     7741 ttcaacatca tatatcgaca aggatgtttc atctggcagg aattacacct atactgtaag
     7801 atgtatttct gctgacggaa agagctttac aagcggttat gattcaaagg ggacaactgt
     7861 aaaatatatt gccgcccccg aaatttcaaa gcttgaaaat gtaaacggcg gtgtgaaaat
     7921 tacatggaac aaagtaagcg gtgcatcaaa gtatagaatt taccagaaaa attcgtcaga
     7981 ttggttcaga gtatcagata cgacttctaa ttctatagtt gataaatctg ttgatgtggg
     8041 aacctatact tataccgtga ggtgtataag tgatgacgga aagagttttg agagtggatt
     8101 taacccaaaa ggctcaagta tcagatatat tcaagctcct aaaatacttg aaaccaatgt
     8161 tgtaaatggc ggtattaagg tgatttggga gactgaaaac aatacaaatt acagattgta
     8221 ctgcaaaaca gaaggtaagg gctggacaaa agtatgcgat accaaaacag gtgttgtgac
     8281 acataaaaat ttacagccga ataaaaccta tacatacact gtaagagcaa tcagttccga
     8341 cgctaaaaag tatttgagcg gttatgaccc tgtgggaatg agcgcaaaat atgttgccac
     8401 accgaaaatt tcaaaaactg aggtcacata tgacggcgta aagctgacat ggaacaaggt
     8461 tgcaggtgca gagaagtacc gtgtgtacta caaagacggt gagggttgga acaaacttgc
     8521 cgatacaacg ggtaacagtt atcttgatat gggacttgta tcaagagaac taagcataaa
     8581 agataattcc gtaaacggtc agtatattta tactgttcgt tgcatttcaa gtaacggcaa
     8641 ggtttttcag agcggttatg atacaaaagg ttctaaggcg aatttaggca atgaatgtcc
     8701 ggagattgtt cgtgttgact caatgcatgg cggaattaca gtttcatgga cagatgtttg
     8761 cgaagataat tcaaagtatc gtatttatgt aaaagaaaaa ggttcgtgga aaaagcttgc
     8821 tgatacaaca aataattatt acactcataa aaatgtaaaa gcaggacaga cctacactta
     8881 taccgtaaga tgtgtttcta aggacggcaa gaaatttaca agtatctata atccgtcagg
     8941 tgtgacattt aagtataaga ctacagataa aacaagagat gcatacatag attatctgct
     9001 caagcatgaa tcggaatggt tacctgaact caaggtagga aatgttgctt tggctggtgt
     9061 gcagtttgcc gatctcgatt ttgacggtgt tcccgagctt atagtacagg aagcaggaga
     9121 taaggaatac tatttgaatg caaaggtgta tacctttaag gacggaaagt tttcgttagt
     9181 cggatttgat gattatagaa cttatatccc gaatcaactg acttatttct atgacaaatc
     9241 tgctaagaaa tatataatta atgccgttga attgtcaacc tcaaatgttg accgttatct
     9301 tgaacgcgaa aactatacat tgaattatga cggcacagtt ttggttgttc gtggatactc
     9361 ttctgctcat ttggctcttg aaagtcgggg attggaatac cattattaca ataataccgg
     9421 aagaacaaca aaacaggcat ataatgccac aaatgtgagt gtactcggta attgtgtaaa
     9481 tgcacatatg tacagtcagt ttgttcactg ttctgttgac ggctatccaa aactttggaa
     9541 taattatagt gaaacacaga agaaacagaa ccttcttgat tcatataacg ctttttctta
     9601 cgacaaatat tgattgtcaa aattgataag atttaactgc aaaagggttc agccgtaaaa
     9661 agctgaaccc ttttattgcg caacaaaaac ggtttagcca aattgactga accgttaatc
     9721 tgtactatgt cacgcttgga aacaagtagt tgtaaattat cacaaactac ctacacgaac
     9781 tgcgagcgag gtactcgcaa aaagggtagc ttgaaaatta taactatgtt aagctcggga
     9841 acaagtagtt gtaaattatc acaaactacc tacacgaact acgagcgagg tactcgcaaa
     9901 aagggtagct tgaaaatcaa gctaccctaa attcgtacta tgtaatgctc gggtgacaga
     9961 agtttgaata tatcaaacta acttcacgaa ctaaaaaaca ttagttgttg atgagcttat
    10021 cttcgtcaga ccagctgtag agctttctaa cttccttacc gaatacttcg gcaggagctt
    10081 cggcagcgag ctttctcata gccttgaagt gaacctgtga accggcatcg ctcatgtcaa
    10141 ggaggaagtc cttagcaaat gtaccgtcct gaatgtcaga aagaaccttt ctcatagcct
    10201 tcttagtatc ctctgtgatg atctttggac ctgtgatgta gtcaccgtac tcagctgtgt
    10261 tagagattga atatctcatg cctgcaaaac ctgactgata gataaggtca acgatgagct
    10321 tcatctcatg gatacactca aagtaagcat ttcttgggtc ataaccggca tcgcaaagtg
    10381 tttcaaaacc tgcctgcata agtgcgcaaa caccgccgca aagaacagcc tgttcaccga
    10441 agaggtctgt ttctgtttct gttctgaatg ttgtttcaag aacgccggct cttgcaccgc
    10501 cgataccgag tgcatatgca agtgcgagat ccttagcctg acctgtagca tcctgctcaa
    10561 cagcaacgag gcaaggtaca cccttaccaa cctgatactc tgaacgaact gtgtgacccg
    10621 gtcccttagg agctaccatt gtaacatcaa catcctttgg aggcttgatg caaccgaagt
    10681 gaatgttaaa gccgtgagcg aacataagca tattgcctgc ttcgaggttt ggctcgatgt
    10741 cgttcttgta aagagctgcc tgcttttcat cgttgataag aatcatgatg atgtcagcct
    10801 gctttgcagc ctctgccgat gtatatacct taaagccctg tgcctcagcc tttgcccagc
    10861 tcttgctgcc tttgtaaaga ccgatgatta catcgcaacc tgaatccttg aggttgagag
    10921 cgtgtgcatg accctggctg ccgtaaccga taatagcaat tttcttaccc ttgagaaggt
    10981 caaggttaca atctgactga tagtagattg gtgctgtcat gttttttgtg tagtctttca
    11041 tattaaagtc ctccttaccg caaacgcggc atataaatta aaatatatgc taactgtaag
    11101 attaaacgga aaccgaagct gtgcctctgt caatggcaac agtacctgtt cttacaatct
    11161 cacggatacc ataaggcttg agtaagtcaa caagcgtgtt gatgcggctt gcacattcgc
    11221 agtactcaac ggtaactgac gaaggggata catcaacgat tttcgcctgc ataatttcaa
    11281 ccgttttgac aatttcggct ctttttgagg cggcgcagtg aaccttgatt aatacaagct
    11341 cacggctgat aaattcgccc tcgttaagcc tttttacctt gatgacagga atgagcttgt
    11401 tgagctgttt ttcaagctgt tcaacaatgt actcgtcacc gtttgcaacg attgtgattc
    11461 gggaaaccga cgggtcctga gtaacaccta ctgcaagtga gtcgatgtta aaacctcggc
    11521 gagagaaaag tcccgaaatt tttgaaagaa cgcccgcctg attttcaaca agtattgata
    11581 atgtatactg cattttatca cctcattaaa ttgacggagt gtcggggtga acatcgcaaa
    11641 caagaatgaa cggtttttcc aaatcaacaa tacccttgat gatgttttcg gcttccttgt
    11701 ttgaatgagc ctctgcatgg tcaatgccgt aagcatcggc aatcttcaag aagtcgggat
    11761 caccgttgag aattgttgcg gagtgtctgc cgccgtagtg tttgtcctga agttcacgaa
    11821 ccattccgag tcgtgcgttt ttcataatga tgattttaat tccgagctga ttgcctgcaa
    11881 tggtcgcaag ctcattaagc cccatctgaa aactgccgtc accgcagatt acaataacat
    11941 cacggtcggg tcttgcaaat tttgcaccga ttgcagcggg aatagagtaa cccattgtac
    12001 ccataccgcc tgttgtgagg aatctgccct cacgaatacg gaagttgttt gcacaccaga
    12061 tttgattttg tcctacatcg gcaacaagaa ttgcctttga gcggaacatt gcactgagat
    12121 ggccgacaag tgttctcggc tcaacaaagc cgtcaaaaac gggaggctca cggtaaagat
    12181 cttttttcca agtctttatg gtttcgctcc acattgttgt aaccttgtaa tcgccgatgc
    12241 tgtcaagcag catattgatg acatttttca tatcgcctac aatcggaatt tctgttttaa
    12301 catttttacc gatttcagca gggtcaatgt caatgtgaat tacctttgtg ttttcactca
    12361 tctggtcggg agccgcaaca gctctgtcac cgagtcttgc accgcatacg attacaaggt
    12421 cggcttcgtg aagagcacgg ttggcaacag ccttgccgtg agtgccgagc attccgagat
    12481 aaagctcatg ctcgctgggc ataacaccga tgcccatcat agttgaaata acggggatac
    12541 ccgtagtttc tgcaaatttt tgaagtttaa gcttgatacc cgaactcagc acgccgccgc
    12601 ctgatacgat aacaggacgc ttgcttgcgt tgatggcctc aacagccttt ttaacctgaa
    12661 ttgcgtgtcc cttagtgttc ggtttgtaac cgataatgtt tacgctttcg ggatattcaa
    12721 aactttcaat ttcattttcc tgaatatcaa cgggaatgtc gataagtaca ggaccgggtc
    12781 tgccggttga ggcaatatgg aaagcctctt tgaaaactct cggaaggtct tctgttttgc
    12841 tgacgagata actgtgcttt acaaacggtt cacaagctcc cgtgatgtca gcttcctgaa
    12901 agacatctct gccgagaagg tcggaacgaa cctgacctgt aatggcaaca atcggaatag
    12961 agtccgtata ggcggtcgca atacctgtga tgaggttggt tgcaccggga ccggaagttg
    13021 ccacgcaaac accgggacga ttactgcatc ttgcatagcc gcttgccgca tgagcagcgt
    13081 tctgttcctg acgaacaaga atgtgggtaa tgctcgagtc gtaaacttta tcgtaaaatg
    13141 ggcagatagc cgcacccgga taaccaaaga ctatgtcaac gccctcggct tccaaacatt
    13201 ttaccataat ttcagcaccg ctgatcatta tgttttgtcc ctcctatcct ttttattgtg
    13261 agcaaaaggt gttttgtaac attaaatata cctttttgct ttaccgctaa ttatacaata
    13321 aataccttaa aaagtaaaga gcagtattgc ccataaatta aattttttgc aggattttga
    13381 cagataattt gcaaaatgga ttttaattga tttttaccgc ctgtttactg aaaatttaag
    13441 t
//
