LOCUS       c00056_gnlPro..        15847 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IIKOKGEM_56.
ACCESSION   c00056_gnlPro..
VERSION     c00056_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 16:44:36
            Original ID  :: gnl|Prokka|IIKOKGEM_56
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15847
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15847
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2301:5847](-)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(2302..5847)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..15847
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15847
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             2..73
                     /locus_tag="ctg56_1"
                     /transl_table=11
                     /translation="RIVPKAFILFGKNKDVCKKDEDV"
     CDS             complement(148..570)
                     /locus_tag="ctg56_2"
                     /transl_table=11
                     /translation="MYVVQRDRLQLSHFFLQQSFIILLSLLSPIPCNPYKQEVREVVAA
                     HYFMYKNAYCHHFIHLVTWYKPTLFVHQTGQACAMNTIGLYGEHGKLVQPRNNDFPCQS
                     IQNLDTSSVGSCSKFHEILYQVLPLHPASFPFGGEG"
     CDS             complement(570..2087)
                     /locus_tag="ctg56_3"
                     /transl_table=11
                     /translation="MNTLTNLKYTLAVTAGLCSSFAYAQNHPHIILIMTDQQRADAIGC
                     MGNDAVISPNLDALAAEGTLFMNGYSSCPSSTPARAGLLTGLSPWHHGLLGYGKVSPEY
                     KYEMPQMLKDAGYYTFGIGKMHWHPQRVKHGFEGTLLDESGRVEDENFTSDYRQWFQTK
                     APGKNPDATGIGWNDHTASIYKLPENLHPTYWTGEMACELISNYDPTNKPLFLKVSFAR
                     PHSPYDPPQRYLDMYEDALIPDPAIGDWCGKYAKKLNPEKTAQDAPYGNFGNEYARNSR
                     RHYYANITFIDEQIGRIIQTLKEKDMYNDALIVFISDHGDMMGDHYHWRKTYPYEGSTH
                     VPYIVKWPSVDHVTPGKTDAPVELRDILPTFLDAADVTIPTDMDGRSLLPLAKGMETTW
                     RKYLDLEHATCYSDDNYWCALTDGKIKYIWRIHTGTEELFDLTQDPQELHNAVNDKKYR
                     KQLTEMRNEMIRHLSERGEEFVKDGRLVVKEKTMLYGPNYPGKENKR"
     CDS             2159..2338
                     /locus_tag="ctg56_4"
                     /transl_table=11
                     /translation="MVKVEIFEIEVLFCAYVCVASYILMVEKGYKKGLFFMNKPFLYAC
                     IRNYSLQFIASIRL"
     CDS             complement(2302..5847)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg56_5"
                     /sec_met_domain="PFOR_II (E-value: 3.7e-18, bitscore: 56.4,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 2.3e-83, bitscore: 269.9,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 1.3e-31, bitscore: 100.5,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-12, bitscore:
                     38.5, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 8.6e-13, bitscore: 39.7,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 9.1e-08, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 3.2e-26, bitscore: 81.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSCRQTGFAMLCEGSVQEVMDMAAVAHLATI
                     KSRVPFVNFFDGFRTSHEIQKIEMLENEDLAGLIDQQALAEFRERALNPNNPVARGMAE
                     NPDHFFQHRESCNNFYEAVPAIVEEYMNEISKITGRPHGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDYLMSKDEKVGLVSVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGTENAPVIVGGRYGLGSKDTTPAQIIAIFKNLALPMPKNHFTVGIVDD
                     VTFTSLPQEEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNITVYYINATQIAQEIGLGNRTNTILQSAFFRITGVIPV
                     DLAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKQLAVDPAWANLEVEAPAANNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWEQGTAQYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGANFETLKAVGKQFDGMTFRIQVDVLDCLGCGNCADV
                     CPGNPKKGGKALTMKHLESQLSQAANWEYCAKNVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTKNEKGQGPAWANS
                     LFEDFCEFGLGMTLADKKLRARIEAAMKDAIASDTCPAEYKEAFQEWIDGKDDADKSKA
                     AAEKIIPMVEAAKDKCKNCATIAEFKNYLVKKSQWIIGGDGASYDIGYGGLDHVIASGE
                     DVNILVLDTEVYSNTGGQSSKATPLGAIAKFAASGKRVRKKDLGMIATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLVIAYAPCINHGLKAGMGKSQAEEAKAVECGYWHLWR
                     FNPALEEEGKNPFMLDSKEPKWEGFQDFLKNEVRFASVMKQYPAEAADLFAACEEMAKK
                     RYASYKRMEAMNWSE"
     CDS             complement(5890..7068)
                     /locus_tag="ctg56_6"
                     /transl_table=11
                     /translation="METFYRTHSYLVEHTNAPVRRDLMDEIDWNDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGTDHSCLFINMNNFYFSKYTLVEFAAEFVKRGGKVLLIDQVFKYPEWS
                     HDLRACYEMFPTLKIIFTGSSVMRLKEENPELSGIVKVYYLRGFSFREYLNLQSGNCFR
                     AYTLQEILENHEQIAKTILRNVKPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMIE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPVAPNVSQLATEIQTSRATVMNYIKYLADAR
                     LINMVYPKGEEFPKKPSKLMMHNTNLMYSIYPVKVEEQDVLDTFFMNTLYKDHKLYKGD
                     KGTSFMVDNGLHFRICAEGCKFKNNPNVYYALHKLELGHGNMIPLWLFGFLY"
     CDS             7172..8383
                     /locus_tag="ctg56_7"
                     /transl_table=11
                     /translation="MVCTLKHLSLCPEMEALYLFNPENDMALACGDPYYMAPASARRMA
                     AELSMLPAWYAEEGGTVWLDSAQRMKTMERQSFLPLSVNWVLEFVPIYNKVIPWGWNPS
                     LVRRLQEAGFPDTAYPSVERMKRIRQISGRQTAVKVLRRLCRHIGGNIPILGEAFVLSS
                     IEEVKAFVLSHSRALLKAPWSGSGRGIQYVSGSFPIPLEGWIRHILTTQHEVIGEPFYD
                     KLLDFAMEFFADEWGQVHFIGYSLFETDKRGVYKENLLAADRVIEARISTYVSAEILHQ
                     VGRALQVELAEVIKGSYEGYLGVDMMICRTQNSGYAIHPCVEINLRMNMGVVARLIYDN
                     YVCDGVQGRYVIEYYAKPGEAWHSHLALQEKYPLYLENGKVKSGYLSLTPVENNTSYQA
                     YILI"
     CDS             complement(8422..9795)
                     /locus_tag="ctg56_8"
                     /transl_table=11
                     /translation="MMKHTLLYIAVSGMTLLTSCQLGKHYTRPDLHLPQQLDTLRQQDT
                     LSIADMQWWEIYTDTTLQSLIEKTLDNNKDMKIAAARVKELAAMKRIDFANLFPQLNGG
                     AYAQKEGSNYGGNNYKNDPELGGKLTVTWELDLWGNLRWAKDKSIAQFLGSIEAQRALK
                     MSIVSEVAQAYFELVALDNELNIVRQTLYARKEGVRLAKLRFEGGLTSETSYQQAQVEY
                     ARTATLVPELERKISLKENDIAFLAGEYPHRIQRSILPEEVKLPETLPVGLPSTLLERR
                     PDVREAEQKLIAANASVGIAYTNMFPRLSLTAQYGVESEEFSDFFKSPIHYISGNLLTP
                     LFAMGKYRATLQAKKAAYEQECYSYEKSVLTAFKEARNAIVDFNKIKDIYESRLQLERS
                     SKATMELAQLQYINGVIGYLDVLDAQRSYFDAQIGLSNAIRDKQITLVKLYKALGGGW"
     CDS             complement(9817..12918)
                     /gene_functions="resistance (resist) RND_efflux (Score:
                     984.9; E-value: 3.4e-298)"
                     /gene_kind="resistance"
                     /locus_tag="ctg56_9"
                     /transl_table=11
                     /translation="MKVSFFIDRPVFSAVISILIVIVGIIGLTMLPIDQYPQITPPVVK
                     ISASYPGASALTVSQAVATPIEQELNGTPGMLYMESNSSNSGGFSATVTFDISADPDLA
                     AVEIQNRIKLAESRLPAEVIQNGISVEKQAASQLLTLCLTSTDPKFDEIYLSNFATLNV
                     LDLIRRIPGVGRVSNIGSRYYAMQIWVQPDKLANFGLTVADLQNALKDQNRESAAGVLG
                     QQPVQGLDVTIPITTQGRLSTVSQFEEIVVRANADGSIIRLRDVARISLEAQSYNTESA
                     INKENAAVLAIYMLPGANAMEVAKSVKEAMEEISKNFPEGMSYEIPFDMTTYISESIHE
                     VYKTLFEALILVIIVVYLSLQSWRATVIPLVAVPISLIGTFGFMLIFGFSLNILTLLGL
                     VLAIGIVVDDAIVVVENVERIMEEEKLSPYQATKKAMEGLTGAIIATSLVLAAVFVPVS
                     FLGGITGQLYRQFTVTIVVSVLLSTVVALTLSPVMCSLILKPEDPNKKKNIIFRRINKW
                     LAIGNHKYVGLIKHIVKHPRRVLSTFGMVLIAILLIHRIIPTSFLPIEDQGYFKIELEL
                     PEGATLERTRIVTERAVEYLMENPAVEYVQSVAGSSPRVGTSQARSELTIILKPWEERD
                     SQTIDDIMAQVKKDMSQYPECKVYLSTPPVIPGLGSSGGFEMQLEARGDATFENLVQAT
                     DTLMYYASKRKELSGLSSALQADIPQLYFDVDRDKVKFAGVPLADVFSTMKAYTGSVYV
                     NDFNMFNRIYRVYIQAEAPYREHKENINLFFVRGTDNAMIPLTSLGTTSYTTGPGSIKR
                     FNMFNSSVIRGEAADGYSSGQAMEIIEQIAREHLPENIGVEWSGLSFQEKQAGGQTGMV
                     LALVFMFVFLFLAALYESWMVPVAVLLSLPVAALGAYLGVWGCGLENDVYFQIGLVMLV
                     GLAAKNAILIVEFAKEQVDRGIDVVQAALHASQLRFRPILMTSLAFILGMLPMVIASGP
                     GSASRQAIGTGVFFGMIFAVTVGILLVPFFFVLIYKMKAKMKQK"
     CDS             complement(12985..14184)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg56_10"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 9e-09, bitscore:
                     25.7, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLFFTHKEIALKKKRTALVVIGIGLVIGIYLIVSHQPAKMPELP
                     VVAIAPATQDDVEIYGEYVGRVRAQQFVEVRARVEGYLEQMLFAEGTYVTKNQVLFVIN
                     QDQYRAKADKARAQLKKDEAQAQKAKRDLERIRPLYEQNAASQLDLDNATAAYETAEAS
                     VAMSSADLDQAELELGYTIVRSPLAGHISERHVDLGTLVGPGGKSLLATIVKSDTVLVD
                     FSMTALDYLKSKERNVNLGQKDSTRSWQPNVSITLADNTIYPYKGLVDFAEPQVDPRTG
                     TFSVRAEMPNPERVLLPGQFTKVKLLLDVRESATVVPLKSVIIEKGGAYIYVMRKDSTV
                     ERRFIELGPEFQNQVVVERGLAPGEDIVIEGYHKLNPGMKVKVSPAVEDKKTEEEDTIG
                     "
ORIGIN
        1 ccgtatcgtt ccgaaagcct ttattctttt cggaaaaaac aaggatgttt gcaaaaaaga
       61 tgaagacgtc tgataaaaag aacaagacgt ttcgtttcaa agatctatat cttccaacct
      121 ttagtttaag tctttccggc tatcggttta tccttctcct ccgaaaggga aggatgctgg
      181 gtgtaacggc aaaacttggt acaggatttc gtggaacttg ctgcaggatc cgacagaact
      241 tgtatcaaga ttctgaatac tttggcaagg aaagtcgttg tttcgaggct gcacaagttt
      301 accgtgttca ccgtacaagc ctatcgtgtt cattgcacag gcttgtcctg tctggtggac
      361 aaacaaagta ggtttgtacc atgtaacaag gtggataaag tggtggcagt aggcattttt
      421 gtacataaaa taatgtgctg ccaccacctc tctaacttcc tgtttatagg ggttgcaggg
      481 aataggtgac aacagtgaca gcagaattat aaaactctgt tgtaggaaaa agtgagacaa
      541 ttggagacga tccctctgta caacgtacat tatcttttat tttctttccc cggataatta
      601 ggtccataaa gcatggtctt ctccttgacc accaatcgac cgtccttcac gaactcttcg
      661 ccgcgttcac ttaaatgacg gatcatttca ttacgcattt ccgtcagctg cttcctgtat
      721 tttttgtcat tgacggcatt gtgcaattcc tgagggtctt gggttaagtc gaataactct
      781 tcggtaccgg tgtggatacg ccatatatat tttattttgc cgtcagtcag tgcgcaccaa
      841 tagttgtcat cactgtaaca ggtggcatgt tctagatcca gatacttgcg ccaggttgtt
      901 tccatgcctt tggcaagtgg caacaaagaa cggccgtcca tgtcagtggg gatggtcaca
      961 tcggctgcat caaggaaagt gggaagaata tcacgtaact ctacaggagc gtctgttttt
     1021 cccggtgtaa cgtggtcgac ggaaggccat ttcacgatgt atggcacatg agtggagccc
     1081 tcgtatggat aagtctttct ccagtgataa tggtcgccca tcatatcgcc atgatcggaa
     1141 atgaaaacga ttaatgcgtc attatacata tccttttctt tcaatgtttg gataattctg
     1201 cctatctgtt cgtcaatgaa agtgatgttg gcataataat gacgtctgga attgcgtgca
     1261 tattcattgc caaaattacc gtatggagca tcttgtgccg tcttttcagg atttagtttt
     1321 tttgcgtatt tgccacacca gtctccgata gcaggatcgg gtattagggc atcctcatac
     1381 atgtccagat atctttgtgg tggatcatac ggactgtgtg gacgggcaaa agaaactttc
     1441 agaaataacg gtttgttggt cggatcgtag ttgctgataa gttcacaggc catttctcct
     1501 gtccaatagg taggatggag gttttcgggc aatttatata tacttgccgt atggtcgttc
     1561 cagcctatac cggtggcgtc aggattcttt ccgggagctt ttgtttggaa ccattggcgg
     1621 taatcactgg tgaagttctc gtcttccacg cgtccgcttt catctagcag agtgccttcg
     1681 aaaccatgtt ttacccgttg gggatgccag tgcattttcc cgattccaaa agtataataa
     1741 ccagcgtctt ttagcatctg tggcatttcg tatttatatt cgggagatac ttttccatat
     1801 cccaacaagc catgatgcca aggagaaagt ccggtcagca gaccagcacg tgccggagtg
     1861 ctgcttggac aagaagaata gccattcata aataatgttc cctcggcagc tagtgcgtct
     1921 aggttagggg agataacagc atcgtttccc atacagccta tggcatcggc tcgctgttgg
     1981 tctgtcatta tcagtatgat atgaggatgg ttttgtgcgt atgcaaaaga ggagcacagt
     2041 ccggctgtga cagccaatgt gtatttcagg ttggttagag tattcatgtt tataggtttt
     2101 tcataatgtt atgtggcaaa ggtaggaaat ttttggtaac cttaagccat aaatagtgat
     2161 ggtaaaagta gaaatatttg aaattgaggt cttattttgt gcatacgtat gcgtggcctc
     2221 atatatacta atggtagaaa aaggttataa aaaaggctta ttcttcatga acaagccttt
     2281 tttatatgca tgtattagaa attattcact ccaattcatt gcttccatac gtttgtaaga
     2341 agcataacgt ttcttggcca tttcttcgca agcagcaaac agatcagcag cttcagcagg
     2401 atactgcttc attacagagg caaaacgaac ttcgttcttc aagaaatcct ggaaaccttc
     2461 ccatttcggt tctttagagt caagcatgaa tggattcttg ccttcttctt ccaaagcagg
     2521 gttgaaacgc cataagtgcc agtaaccgca ttctacagcc ttagcctctt cagcctggct
     2581 cttacccata cctgccttca aaccgtggtt gatacacgga gcgtaagcga taaccaatga
     2641 cggaccggga taagcttctg cttcacggat agctttcaaa gtctgagctt ggtcagcacc
     2701 catagcaatc tgggcaacat atacataacc gtaagtagta gcgatcatac caaggtcttt
     2761 cttacgtaca cgcttacctg aagcggcaaa cttagcgata gcacccagcg gagtagcctt
     2821 agatgactga ccaccagtat tagagtaaac ttcagtatcc aataccaaaa tatttacatc
     2881 ttcgccggaa gcaatcacat ggtccaaacc accgtaaccg atatcgtaag aagcaccgtc
     2941 accaccgata atccattggc tcttcttaac caaatagttc ttgaattctg caatggtagc
     3001 gcagttctta catttatctt tagcagcttc caccattgga atgatctttt cggcagcggc
     3061 tttgctcttg tctgcatcgt ccttaccatc aatccattcc tggaatgctt ctttgtattc
     3121 tgctggacaa gtatcactgg cgatagcatc cttcatagca gcttcgatac gtgcacgaag
     3181 tttcttgtca gccaaagtca tacccaaacc gaattcgcag aaatcttcga acaatgagtt
     3241 agcccaagca ggaccttgac ccttttcgtt cttagtataa ggagttgaag gaacagaacc
     3301 agagtagata gaagaacatc cggtagcgtt agcaaccatt tcacggtcac cgaataactg
     3361 ggaaatcagt ttcacatatg gagtttcacc acaacctgaa caagctccag agaattcgaa
     3421 caacggagta gcgaactgag agttcttcac attggctttg atatctacta aatgttgttt
     3481 gctcttcacg ttcttagcgc agtattccca attggctgct tgagacaact ggctttccaa
     3541 atgtttcatt gtaagagcct tgcctccctt cttcggattg cccggacaaa catcagcaca
     3601 gttaccacaa cccagacagt caagcacgtc aacctggata cggaatgtca ttccgtcaaa
     3661 ttgtttacct acagctttca atgtctcgaa gtttgcaccc ttttgttctt cagcgtcaag
     3721 tacgaacgga cggatagaag catgaggaca aacatatgca cacttgttac actggataca
     3781 gttttcagca ttccattcag gtacgaatgc agctacacca cgtttttcgt attgagcagt
     3841 accttgttcc caagtaccgt cttcgatgcc tttgaatgca gataccggca acaagtcacc
     3901 atcctgagcg ttgataggac gaactacttc gttgatgaat gcagggtcat tgttagcagc
     3961 aggagcttca acttccagat tagcccaagc cggatcaaca gccaattgtt tgtattcgcc
     4021 accacggtct acggcagcat agttcttgtt caccacgtct tcgcccttct tgccataaga
     4081 cttaacgatg aatttcttca tctgttctac agccaagtca acaggaataa cgcctgtgat
     4141 acggaagaat gctgattgca ggatggtatt ggtacggttg cccaaaccga tttcctgagc
     4201 aatctgagtt gcattgatat agtaaacagt aatgttgttt tgtgcgaaat atttcttaac
     4261 cttgttcggt aagttcttgg ccagttcttc accttcccaa atagtgttca acaagaaaga
     4321 accgttctta cgtaaaccac gagttacatc gtacatgtgc aaataagctt gtacgtggca
     4381 agctacgaag ttcggagtat ttactaaata agtagaacgg ataggagtat cgccgaaacg
     4441 gaggtgagag caagtgaaac caccagattt cttagagtcg tatgagaaat aagcctgaca
     4501 gtgcttgtcg gtgttgtcac cgataatttt cactgagttc ttgttagcac ctacagtacc
     4561 gtcagcacct aatccgtaga atttagcttc aaacatacct tcgccgccta atgcgatttc
     4621 ttcttcttga ggaagagaag tgaaagttac atcgtctacg atacccacag tgaagtggtt
     4681 tttcggcatt ggcagagcca aattcttgaa tatagcgatg atttgagcag gagtagtgtc
     4741 tttagaacct aaaccgtaac gtccacctac gataaccgga gcgttttctg ttccatagaa
     4801 gcagtcttta acatccagat acaaaggttc gccgtttgct cccggttctt tagtacggtc
     4861 aagaactgcg atagtcttgg cagtcttagg tacagcagcc aagaaatgtt tagcagagaa
     4921 cggacggtat aaatgtacag aaaccaaacc tactttttca tctttgctca tcaagtagtc
     4981 gatagcttcg cgggcagctt ctgtaacaga acccattgcg ataattacgc gttcagcgtc
     5041 ttcagcacca tagtaatcga acaaaccatg agggcggcct gtgattttgc tgatttcgtt
     5101 catgtattct tctacgatag ccggaactgc ttcatagaag ttattgcaag attctctgtg
     5161 ctggaagaag tggtcggggt tttcagccat accgcgtgca acagggttgt taggattcaa
     5221 cgcgcgttca cggaattctg ccaaagcctg ttgatcaatc agacctgcca gatcttcatt
     5281 ctccagcatt tcaatttttt ggatttcgtg agaagtacgg aaaccatcga agaagttgac
     5341 gaatggcacg cgagatttga tagtagcaag atgagctaca gcagccatat ccataacttc
     5401 ttgtacagaa ccttcgcaca acatggcgaa acctgtttgg cggcaagaca tgacgtcctg
     5461 atggtcacca aagatacaca atgcgtgtga agccaatgta cgagccgata cgtggaatac
     5521 gcaaggcagg aattcaccgg caattttgta catgttaggg atcatcagca acagaccctg
     5581 agatgcagtg taagtggtag tcaacgcacc tgcctgaaga gaaccatgaa cagcacctgc
     5641 tgcaccgcct tctgactgca tttcttgtac caaaactgtt tcgccgaaga tgtttttacg
     5701 acctgcggca gcccattcgt ctacgtattc agccatagta gacgacggag tgatgggata
     5761 gatagcagct acttcagaga acatatatga gatatgtgct gctgcctggt taccatcaca
     5821 agtgatgaat tttttttgtt tagtcataca attactaatt attaggtaat aaaatctatt
     5881 ctctatctct taatataaaa agccgaaaag ccataatggg atcatatttc cgtgtcctaa
     5941 ttccaatttg tgtagggcat aatacacgtt tggattattt ttgaacttgc acccttctgc
     6001 gcaaatacgg aaatgcagtc cgttgtctac cataaatgaa gtgcctttat cgcctttata
     6061 tagtttatgg tccttataca gggtattcat gaaaaatgta tccagtacat cctgttcttc
     6121 gacctttacc ggataaatgg agtacatcag gttggtgttg tgcatcatca gtttggaagg
     6181 tttcttggga aattcctctc ccttgggata aaccatattg ataagacgcg catctgccag
     6241 atacttaatg taattcatca ccgtggcacg tgaagtttga atctccgtgg ccagctggct
     6301 gacgttcgga gcaacgggtc cgtccacagc tagcaaatat agtaattttt ttatctttga
     6361 aagatatttc agctcaattt gtttgataag aagtatatct acttctatca tcatattcat
     6421 ggtttttagc agattctccg aaaagttacg tttttccagg aagaatgggt agaaaccgtg
     6481 atgcagatag tcttgaaaat aatccaaggg cttcacgttg cgcaggatgg ttttcgctat
     6541 ctgttcgtga ttctccaaaa tttcttgtaa ggtataggca cggaaacaat tgccgctttg
     6601 caaattcaga tattcgcgga atgagaaacc tctcagatag tataccttga caatgccgct
     6661 cagttctgga ttttcttctt tcagtcgcat cacagatgat ccggtgaata taatcttcag
     6721 agtaggaaac atttcatagc aagcacgcag gtcgtggctc cattcgggat acttaaacac
     6781 ttggtctatc aacaaaactt ttcctcctcg ttttacgaat tctgcggcaa actccactaa
     6841 tgtatattta gagaagtaaa agttattcat gttgatgaac agacatgagt gatccgttcc
     6901 gaacttttct tttgcatatt gcaggaggaa agtcgttttc cctacgccac gagtaccctt
     6961 gataccgatc agtctgtcat tccagtctat ctcgtccatc aagtcccggc gaacaggagc
     7021 atttgtatgt tccaccagat aactgtgtgt tctgtaaaag gtttccatgg ttgctttttt
     7081 atcggctgca aatatagcaa tactaattca aattgcaaac tggagatagc aaaatattat
     7141 ttttttttct actaaaagac ggacaagaga aatggtttgt actctaaaac atttatcttt
     7201 gtgtccggaa atggaagcgc tttatttatt caatccggaa aatgatatgg cattagcttg
     7261 tggtgatcct tattatatgg cacctgccag tgcacgacga atggcggccg agctatccat
     7321 gttgcctgca tggtatgcag aagagggagg aactgtgtgg ctggattctg ctcagcgtat
     7381 gaaaacaatg gaaagacaat cttttttgcc gctttcggtc aattgggttt tagaattcgt
     7441 acccatttat aataaggtga ttccttgggg atggaatccg tctttggtgc gtcgtttgca
     7501 ggaagctgga tttcctgata cagcatatcc ttcagtagag cgtatgaagc gtatccgtca
     7561 aatatccgga cgtcagacgg ctgtaaaagt gttacgccgc ctatgtagac atataggtgg
     7621 gaatattccc atattggggg aggcttttgt attgtcgtca atagaggaag tgaaggcttt
     7681 tgtgttgtct cattctcgtg ctttgttaaa agcgccatgg tctggtagtg gaagagggat
     7741 acaatatgtt tcaggtagtt ttcccatccc tctggaaggg tggattcgac acatacttac
     7801 cactcagcat gaggtgatag gagaaccttt ttatgataag cttttggatt ttgccatgga
     7861 gttttttgca gacgagtggg gacaggtaca ttttataggg tattccttat ttgaaacgga
     7921 taagagaggt gtttataaag aaaacttgtt ggcggcggat cgggttattg aagcgaggat
     7981 atccacttat gtttctgcgg aaatcttaca tcaggttggg agggcgttac aggtagagtt
     8041 ggcagaggtg ataaaaggga gttacgaagg ctatctgggg gtggatatga tgatatgccg
     8101 tacccaaaat agcgggtatg ccattcatcc gtgtgtggaa ataaatcttc gtatgaatat
     8161 gggagtggta gcacgcttga tatatgataa ctatgtgtgt gatggcgtgc agggacgata
     8221 tgttatagaa tattatgcaa agcctggtga ggcatggcat tctcatcttg cgcttcaaga
     8281 aaagtatcct ttatatctgg agaatggaaa agtgaagtcg ggttatttgt cacttacacc
     8341 ggtagagaac aatacgtcct atcaggcata tatcttaatt tgattttccg gataaaggaa
     8401 gatacagaaa agaggggatg gttaccatcc accccctaat gctttataca attttactaa
     8461 tgtaatctgt ttgtctctta ttgcattgct taatcctatt tgtgcgtcga aatagctacg
     8521 ttgtgcatcc aatacatcta gatagcctat tactccattg atgtattgca attgggccag
     8581 ttccattgtt gctttagagg aacgttccag ttgcaggcgc gattcgtaga tatcttttat
     8641 cttattgaag tccacaatgg cattgcgggc ctctttgaat gcagtcagca ctgatttttc
     8701 atagctgtag cattcctgtt cgtatgcggc ctttttggcc tgtagggttg ctctgtattt
     8761 tcccatggcg aagagaggag ttagaagatt gccactgata taatgaatgg gcgatttgaa
     8821 gaaatcagag aattcttcac tttctacgcc atattgtgct gtgaggctaa gtcgtgggaa
     8881 catattggta taggcaatac ctacactggc attggctgct attaatttct gttctgcttc
     8941 acgtacatcg ggacgacgtt ccagcagagt ggagggtaga cctactggta atgtttcagg
     9001 tagttttact tcttcgggta gaatggaacg ctgtatgcgg tgcgggtatt cgcctgctaa
     9061 aaatgcaata tcattttctt tcaatgaaat tttcctttct agttcaggaa ctaaagttgc
     9121 ggtacgtgca tactccactt gtgcctgttg ataagaagtt tctgaagtta gtcctccttc
     9181 aaaacgaagt tttgccaagc gtactccttc tttacgggca tagagtgttt gacgaacaat
     9241 gttcagctca ttgtctaatg cgaccaattc aaaataggct tgtgccactt cggacacaat
     9301 actcattttc aaggcacgtt gcgcctcgat gcttcccagg aattgtgcta tgcttttgtc
     9361 ttttgcccaa cgcaggttac cccataggtc taattcccaa gttacggtaa gtttaccacc
     9421 cagttcgggg tcatttttat agttgttacc accataatta cttccttctt tttgagcata
     9481 agcgcctccg ttcagttggg ggaaaaggtt ggcaaagtct atgcgcttca ttgcggcaag
     9541 ttcttttaca cgtgccgcag caattttcat gtctttgttg ttatccaacg ttttttctat
     9601 caagctttgc aaggttgtgt ccgtatagat ttcccaccac tgcatatcgg caatagataa
     9661 tgtatcctgt tgtcgtagcg tatctaattg ttggggcaga tgcaagtcgg gacgtgtgta
     9721 gtgcttacct aattggcaag aagtcagcaa agtcattcct gatacggcta tatataataa
     9781 tgtatgtttc atcatttctt tcgtcttttt atatccttat ttttgtttca ttttcgcttt
     9841 catcttgtat atcagtacaa agaagaaagg tactaacaaa attcccacag ttacagcaaa
     9901 gatcattccg aagaatacac ctgtaccaat agcttgacgg ctggctgaac ctggcccgct
     9961 ggcgataacc ataggtaaca tacctaagat gaatgccaat gaagtcatca aaataggtcg
    10021 aaagcggagt tgtgaagcat ggagtgcagc ttgtaccaca tctattcctc tgtccacttg
    10081 ttctttggca aactctacaa taagaattgc atttttggcg gccagtccta ccaacatcac
    10141 caatccgatc tggaaataga catcattctc caacccacag ccccatacac ctagataggc
    10201 acctaatgcg gctacaggta aagagagtaa tactgcaacc ggtaccatcc agctttcgta
    10261 taaggcagca aggaacaaaa acacgaacat gaacactaat gccagcacca taccggtctg
    10321 tccacctgct tgtttttcct ggaaagatag tccgctccat tctacaccga tattttctgg
    10381 taggtgttcg cgagctattt gttcgataat ttccatggcc tgtcctgaac tgtaaccatc
    10441 tgcggcctca ccgcgaatca cagaactgtt gaacatatta aaacgtttga tgctgcccgg
    10501 acctgtggta tacgaagtgg tacccaacga ggtgagcggt atcatggcat tgtctgtacc
    10561 ccgtacaaaa aataggttga tattctcctt atgttcccgg tagggtgctt ctgcttgaat
    10621 atatacacgg tagatacgat taaacatatt gaaatcgttt acatataccg aacctgtata
    10681 agctttcatg gtcgagaata catctgctaa aggtactcct gcgaatttta ctttgtcacg
    10741 gtctacatcg aaataaagtt gggggatgtc cgcttgtaaa gccgaggata aacctgataa
    10801 ttccttacgt tttgatgcat aatacatcaa tgtatccgta gcttgtacca aattttcaaa
    10861 agtggcatct ccacgtgctt ccagttgcat ctcgaaacca cccgaactgc ccaatcccgg
    10921 aataacggga ggggtggaaa gatatacctt gcattcgggg tattgcgaca tgtctttttt
    10981 tacctgtgcc ataatatcgt caatagtttg cgagtcacgt tcctcccaag gttttaagat
    11041 gatagtcagt tcacttcgtg cctgactggt ccctacacgc ggactgcttc ctgccacgct
    11101 ttgtacatat tccactgccg gattttccat caggtattcc acagcacgtt ccgtcacgat
    11161 acgtgtacgt tccaacgttg caccttcggg cagttccaac tctattttaa aatatccttg
    11221 gtcttcgatg gggaggaagc tggtgggaat aatgcgatgg attaacagga tggcgatcaa
    11281 taccatgccg aatgtgctca gtacccgacg cgggtgtttc acaatgtgct tgatgagtcc
    11341 tacatattta tgattgccga tagccagcca cttattgata cggcggaata tgatattctt
    11401 tttcttgttc ggatcttccg gtttcagaat aagtgaacac atgactggac tcagtgtcaa
    11461 agctactacc gtagacagta atacagatac tacgatggtt accgtaaact ggcgataaag
    11521 ttgtccggta attccaccta gaaaacttac gggaacaaat actgctgcca gtaccaaaga
    11581 agtggcgata atggctcctg taagtccttc catagctttc ttggtagctt ggtagggaga
    11641 tagtttctcc tcttccatga tacgctccac attctctact accacgatag catcgtccac
    11701 cacaataccg atggcaagta ccaatcccaa cagggtcagg atattaagcg agaatccgaa
    11761 aatcaacata aatccaaaag ttccaatcag tgagataggt acggcaacta gtgggataac
    11821 tgttgcacgc cagctttgga gtgaaaggta tactacgatg ataaccagta tcagggcttc
    11881 aaacagtgtt ttgtacactt catgaatgga ttccgaaata tacgtagtca tatcgaaagg
    11941 tatctcgtaa ctcattcctt cgggaaaatt cttgctgatt tcctccatag cttctttcac
    12001 gctttttgct acttccatag cgttggctcc tggtaacata tagatggcca ataccgctgc
    12061 attttctttg ttgatggcac tctcggtatt gtatgattgt gcttcgagtg agatgcgggc
    12121 cacatcacgc aaacggatga tggaaccatc ggcattagca cggactacga tttcctcaaa
    12181 ctggcttacg gtagatagac gtccctgagt agtgatggga atggttacgt ctaatccttg
    12241 tacgggttgt tgtcccagta caccggctgc tgattctcga ttttggtctt ttagtgcatt
    12301 ctgcaagtcg gctacagtca gaccgaaatt ggccagtttg tcgggttgta cccagatttg
    12361 catggcataa tatcggcttc cgatgtttga aacacgtcct acgccaggga tacggcggat
    12421 taggtccagc acattcagag tggcaaagtt gctaaggtat atttcatcga acttcgggtc
    12481 ggtagaggta aggcataggg tcagcaattg actggcagcc tgtttctcta ccgaaatacc
    12541 attttgtata acttctgctg ggaggcgtga ttctgctaac ttgatacggt tctgtatttc
    12601 cactgccgct agatcgggat ctgccgagat atcaaaagtg acggtggctg aaaaacctcc
    12661 cgaattggaa ctatttgatt ccatgtaaag cattcctggg gtaccgttca attcctgctc
    12721 tataggagtg gctacagcct gtgatactgt cagggcactg gcacccggat aggatgcgct
    12781 gattttcact accggcggag taatctgcgg atattggtca atgggtagca tcgtgagacc
    12841 gatgataccg acaatgacta ttaatatgga gatgacagct gaaaataccg gtctgtctat
    12901 aaagaaacta actttcataa tgtctattgt ttttttgaat gcgtaaattt tcctccatag
    12961 gggaattcgt attcgggagt gaaattatcc gatcgtatct tcttcctccg tttttttgtc
    13021 ctctacggca ggacttactt ttactttcat gcctggattc agcttgtggt atccttctat
    13081 gacaatgtct tctccggggg ccaagcctct ttccaccact acttgatttt ggaattcagg
    13141 acctaattca atgaaacgtc tctctactgt agaatctttg cgcattacat aaatataggc
    13201 gccacctttt tctatgataa cggactttaa cgggactacc gtagcactct ctctgacatc
    13261 caataatagt tttactttgg tgaactgccc aggaagtaat acccgttctg gattcggcat
    13321 ttcggcacgt acggagaatg tacctgtgcg tggatcaact tgcggttcgg caaagtctac
    13381 tagtcctttg tatggataaa tagtattatc tgccaaagta atggatacat tgggttgcca
    13441 ggagcgggtg gagtcttttt gacctaagtt cacattacgt tctttacttt tcagatagtc
    13501 tagagcagtc atgctgaaat ccactaatac agtatcactt tttactatgg tagcaagcaa
    13561 tgatttgcca cccggaccga ctaatgttcc taaatctacg tgacgttcac tgatatgccc
    13621 tgctaatgga gaacgaacta tagtataacc tagttccagt tctgcttgat caagatcggc
    13681 actactcata gctaccgacg cttctgctgt ttcatatgca gcagtagcat tgtccaagtc
    13741 caactggctg gcagcgtttt gttcatatag cggacggata cgttctaagt cgcgttttgc
    13801 tttttgtgct tgtgcctcat cctttttcaa ttgggcgcgc gctttgtcag ctttggcccg
    13861 atattgatct tgattgataa caaacagcac ttgattttta gtgacatatg taccttctgc
    13921 gaaaagcatt tgttctaaat atccctctac tcgggcacgt acttcaacga attgctgtgc
    13981 acgtacgcgt cctacatatt caccatatat ttccacatcg tcttgcgttg ctggtgctat
    14041 ggcaactact ggaagttccg gcatctttgc cggttgatgg gaaacaatca ggtaaatccc
    14101 gataactagt ccaataccta ttactacaag cgctgttctt ttctttttta gcgcaatttc
    14161 tttgtgtgta aaaaatagtt tcatacttta gttttgttat tgtttaagat gccatcagta
    14221 gaaatacaag cagcgtgcca aactattgta aatagtcttt cctattcata atcagtgctt
    14281 tatttctgtc ttttgttgat agggaaagtg tggaaaatag gcaacagctg tagaataatt
    14341 ccacagtagg cgtaattaaa tttagtagag gattatcgat ttggatgcaa aaatagtaaa
    14401 atagtgggta atcttaaaat atttattcac tattcattat aatgaggaag atgttatagt
    14461 gttagcagat atgtatgcaa tttaaatttt gcttgagatc gtcgtatctg caaccttatt
    14521 gttttgaaaa cacgccccct ttcattttga aaagggttgt gtttttcttt tttatgactg
    14581 aatatggtat ctgtttgttt atcaggagat tataatctgc tttttcattt tggcatagta
    14641 ttcgctatat acttgtcaaa tataaaaggt ataaaaagat gggagaattt tataatccag
    14701 ataaattata taaaggtgga agccgaaata atagcttgat aaataaaaaa atgatattcc
    14761 gtgtattggg agtattactt tttattgaat ctgctatgtt tctgctttgt gcggctattt
    14821 ccttatgtta cggcgagcaa gattatcaat attttctata taccattctt ttgaatacat
    14881 tagtcggtgg agttttgcta atttgtagta gaggtgctga gaatcgacta acacgacgag
    14941 atgggtactg tattgtaact tttacttggt ttttgtttac gttgtttgga atgctacctt
    15001 tttattttag tggaggaatc ccttcagtga cagatgcttt ttttgaaacc atgtcgggtt
    15061 ttactactac aggagctact atattagatg atatagaatc tctttcacat ggcctgttat
    15121 tttggcgtag cctgacacaa tggataggtg gcttgggtat tgtttttttt actattgctg
    15181 tgcttcctat tttcggggga ggaactatac aacttttttc agctgaggct atcggagtga
    15241 cgcacgacaa aacacatcct cggattgatg tgatggctaa gtggctgtgg atgatatatg
    15301 ctatccttac agttgtagaa actatgttgc tgatgatagg aggaatgagt ttttttgacg
    15361 cggtatgtca ttcattctct acaacggcta caggtggtta ttctactaaa caagccagtg
    15421 tggcttattg gaattctccg tttatagaat atgtaatagc gatatttatg attctttcgg
    15481 gtattaattt ctctctctat tttatgtgcc tgaaagggaa gggcaagcgt ctatttcagg
    15541 atgatgaatt ccgttggttt atgaaatcag taagtattct gacgcttgtt atcacgcttg
    15601 ccttagtttt tcagaatcat tatgattggg aaaaggcatt ccgcagggct ctgttccaag
    15661 tggctacggc acatacgtca tgcggttttg caacggatga ttataacttg tggccatctt
    15721 ttacatggat gcttcttatt tttgctatgt tgtcgggtgg atgtacgggg tctactagtg
    15781 ggggaatcaa aaacatgcgc cttatgattc tggcgcgtaa tatcaagaat gaattcaaac
    15841 ggatgct
//
