LOCUS       gnlProkkaHEJOHAOE_57   10969 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HEJOHAOE_57.
ACCESSION   gnlProkkaHEJOHAOE_57
VERSION     gnlProkkaHEJOHAOE_57
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 11:55:11
            Original ID  :: gnl|Prokka|HEJOHAOE_57
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10969
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10969
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4580:5954]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4581..5954
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..10969
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10969
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             complement(3..1106)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg57_1"
                     /sec_met_domain="PF04055 (E-value: 1e-21, bitscore: 67.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFPIFSYTFQIEAETCVSASKSFMRFFMSNSIGLYIHIPFCKHK
                     CPYCDFFSGNADEKAFDNYVIELKDKIKYWSEKAKRDVATVYFGGGTPSVLGADRLCDI
                     LDFIKFNFNIQNNAEITVEVNPDSAKTIDFEKMYACGFNRISMGMQTAVEDELRLLGRI
                     HSIDDAKTSVERAKSAGFNNISLDLMMGIPNQTIESLEKSISFCADCKVTHISSYILKI
                     EENTPFYKVQNKLKLADDDMQAEMYLKAVEMLDSLGYKQYEISNFAKQGYESRHNTNYW
                     RCGEYIGIGPSAHSFFEGKRFFYSRSMDDFNNNKLSFEGTGGDEEEFIMLSLRLKSGLN
                     YYEFEEKFGYTLPSYIIKKAKEYEKYGY"
     CDS             1272..2858
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190:GTP-binding protein LepA (Score: 109.2; E-value:
                     4e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg57_2"
                     /transl_table=11
                     /translation="MSSFKEEISKRRTFAIISHPDAGKTTLTEKLLLYGGAINLAGSVK
                     GKRTAKHAVSDWMEIEKQRGISVTSSVLQFKYNGYCINILDTPGHEDFSEDTYRTLMAA
                     DSAVMVIDGSKGVEKQTIKLFKVCVMRNIPIITFINKMDRDAKNSFDLLEDIENVLGIH
                     TYPVNWPIGSGKEFKGVYDRNSKKILAFTANNGQKEVEKKELTLDDPALEDTIGYYHKQ
                     DLFDEIELLDGAGDEFDLEAVRNGQLTPVFFGSALTNFGVEPFLEQFLQLTTPPLPRET
                     VNEKVEPMSDFFSAFVFKIQANMNKAHRDRVAFMRICSGKFEKNMEVFHVQGNKKMRLS
                     QPQQIMAQEREIVDEAYAGDIIGVFDPGIFSIGDTICSPGHKVQFRGIPTFAPEHFALV
                     RQKDTMKRKQFIKGTSQIAQEGAIQIFQELDAGMEEVIVGVVGVLQFDVLKYRLQNEYN
                     CDIIMETLPYEFIRWIVNDDIDPKTLDLASDTKKIQDLKGNHLLLFTSYWSINWALEHN
                     KGLELAEFGTN"
     CDS             2882..4285
                     /NRPS_PKS="Domain: Aminotran_5 (54-217). E-value: 3.5e-13.
                     Score: 41.0. Matches aSDomain:
                     nrpspksdomains_ctg57_3_Aminotran_5.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg57_3"
                     /sec_met_domain="Aminotran_1_2 (E-value: 3.5e-13, bitscore:
                     38.4, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.2e-09,
                     bitscore: 26.9, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 1.1e-13, bitscore:
                     39.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYDKLKNYSKSGIYPFHMPGHKRTDITEEGIIPYNIDITEIHDF
                     DNLHSPNGVIDEIQKKAAKLYNAKNAFIMINGSTGGILSAIRSMTNQGDKILMARNCHK
                     SVYNSAELFDLNVDYIFPDTDSRYNILTSVSPCDIEDKLTKHNDEIRLVIITSPTYEGV
                     VSDIKSISEICHKHGAKLLVDEAHGAHFPFSDSFPDEALNCGADAAVLSLHKTLPSLTQ
                     TALLITNDSELSEILAENLAVFETSSPSYILMSSIEKCLDFCENSKDKFKEYCRNLKTV
                     REKLKNLKYLKIYDKSDTDFDYDIGKIVISTANANISGTKLAEILRNNYQIETEMAYSD
                     YVIAMTSVCDTEKGFDMLSDALISIDSELLKEADTERVPLKNLYTGKNFNACELYKFNK
                     ETIPFQNSEFRTSAEYIWAYPPGIPLIVPGEIISKELINYIEYLSACKVEIMSTKGGMT
                     DNISVVKKD"
     aSDomain        3044..3532
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg57_3_Aminotran_5.1"
                     /evalue="3.50E-13"
                     /label="ctg57_3_Aminotran_5.1"
                     /locus_tag="ctg57_3"
                     /protein_end="217"
                     /protein_start="54"
                     /score="41.0"
                     /tool="antismash"
                     /translation="IDEIQKKAAKLYNAKNAFIMINGSTGGILSAIRSMTNQGDKILMA
                     RNCHKSVYNSAELFDLNVDYIFPDTDSRYNILTSVSPCDIEDKLTKHNDEIRLVIITSP
                     TYEGVVSDIKSISEICHKHGAKLLVDEAHGAHFPFSDSFPDEALNCGADAAVLSLHKTL
                     "
     CDS             4581..5954
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg57_4"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 8.1e-32,
                     bitscore: 98.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.7e-15, bitscore: 46.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.8e-15, bitscore: 46.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 6.4e-21, bitscore:
                     63.8, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQYKLNGYNIVLDVYSGSVHAVDDLAYDVIAMYKNATKEQIID
                     EMLSKYADNPEITKEEISDCIDDVKELEEQGKLFTDDKYENLAFDFKKRNTVIKALCLH
                     IAHTCNLNCEYCFASQGKYHGERALMSFEVGKRAIDFLIENSGSRVNLEVDFFGGEPLM
                     NFDVVKQIVAYARSIEKEHNKNFRFTLTTNGMLVDDDVIEFANKECHNVVLSLDGRKEV
                     HDHLRKTVNGKGSYDIIVPKFQEFVKKRGNKGYYVRGTYTHNNTDFTNDIFHMADLGFT
                     ELSMEPVVCAPDDPYALTYDDLPVLFEQYEILAKEMLKREKEGRPLTFYHYMIDLTGGP
                     CIYKRISGCGSGTEYMAVTPWGDLYPCHQFVGDEKYKLGDIFNGVSNTKIQDEFKLCNA
                     YARPDCKDCWARLYCSGGCAANAYHATGSITGIYEYGCELFRKRMECAIMMKVAEAEE"
     CDS             6020..6829
                     /locus_tag="ctg57_5"
                     /transl_table=11
                     /translation="MNEKIIMLGTGSAMVTDCYNTCFLLKSENDCLLVDAGGGNGILSA
                     IKKSGIAWNSIKTMFITHSHTDHILGAVWVIRQISALMNSGKYDGNFNIYCHDECVDSI
                     TAICNHTLAPKFLKNINTKIFINEVKDGEKQNAGSIRLTFFDIFSDKTKQFGFKAVFPS
                     GKVLACLGDEPFNEKCRNFVQNCDYLMCEAFCLYSQKDIFKPYEKFHSTALDAGKLAES
                     LFAKNLILYHTEDETLRTRKRTYTSEAGTVFNGNIFVPDDFEVIDLK"
     CDS             complement(6821..8734)
                     /locus_tag="ctg57_6"
                     /transl_table=11
                     /translation="MFSTDKSSFNKKDVSDCDYKISLAGNPNVGKSTIFNELTGLRQHT
                     GNWTGKTVDFAKGSCKIKDARFCITDLPGCYSLLSFSGEEAVTRDCLIQNQNDCVVIVV
                     DCGVIERNLSFALQVLSVTKNAVLCLNLCDEAEKNGIKIDCDELSLNLGIPVVKTCATD
                     KKGLDELKEAIYDVCSGKTKCFRVKRNFEGVDILSEKNYKQNIEKLSQTGSKISNDCVK
                     YEKSELNACTRKLDKILTSKTAGIPIMLAMLGILFWITVVGANYPSEWLSNLFGFIKEK
                     LYILFDFLHAPDVVTGLLIDGVYTTLSWVVSVMLPPMAIFFPLFSLVEDSGYLPRIAFN
                     LDRHFSKCGAHGKQSLTMAMGLGCNACGVTGCRIIESPKERLIAILTNNFMPCNGRFPT
                     IIALLLMFFAGTAFTLSSSIEVAALLIGIIVFCVFITLVISKVLSVTILKGEQSGFVLE
                     LPPYRKPQILKTIVRSLLDRTLFVLGRAVAVAAPAGAIIWILANVHISDVSLLKYCTDF
                     LDPFGRFIGVDGVIIMAFILGFPANETVIPIIIMSYMASGTLVDYSSYDQLFQLLSMNG
                     WTITTAVCTIILCILHYPCSTTCLTIKKETGSLKWTLVSMALPTAMGIVLCMITAGVMR
                     LF"
     CDS             complement(8749..8985)
                     /locus_tag="ctg57_7"
                     /transl_table=11
                     /translation="MKEKCSLDKLPLGVTGIVYRVNCNENIKNRIFDFGIMENSPVIPL
                     FTSPFGDPSAYLVKNAVVALRNNDCKNIIVTPE"
     CDS             9451..10968
                     /locus_tag="ctg57_8"
                     /transl_table=11
                     /translation="MNKSFKKILSIVLSVMMISSLMTVSLSVSAVEDGKVRVIVRNDTY
                     SVENGAPWDGVLVDEWVSIDNDSTMMSAVVDALNNHGYTQEGAESNYFSSINGLAASDG
                     GAMSGWMGTLNDWFTNYGFADITVASGNLESGDEIAIMYTSNGYGEDIGGTWANNDTTV
                     KSVEITGAELTGKFDPSVTDYTLTIGTPSADVNVVPTATNKNFQTRKYKNEYLPSDDSA
                     FYKRSQTVNVSDGDKIIIGCGDTAWPSMNTSEGGTVYTFTVKYAPSAADTVSNKIDEVA
                     KYLASQDAPTVSSVGGEWTVLGLARAGKITDEIADSYYQNAVKYVEEKGSAKLHNTKST
                     DNSRVILALTAIGKDVTDVASYNLLEPLADMDYVKKQGINGPVFALIALDTGDYEIPQT
                     DAANPTTREKLVQTILDAQVANGGWTFFGKTADPDMTGMAIQALAPYYSSNSDVKEAID
                     KALTVMSNAQNENGGFASWGSVNSESCAQVLVALTSLGIDPTNDERFI"
ORIGIN
        1 gtatagccgt atttttcata ctctttagct tttttgataa tgtaagaggg gagggtgtat
       61 ccgaattttt cctcaaattc ataataatta agaccgcttt ttaacctgag tgagagcata
      121 ataaattcct cctcatctcc gcccgtacct tcaaaagaca gcttattgtt attaaaatcg
      181 tccatgcttc tcgaataaaa gaaccttttg ccctcaaaaa atgagtgtgc agacggacct
      241 atgccgatat attcaccgca tctccagtaa ttggtattat gtcggctttc gtaaccctgt
      301 tttgcaaaat tagaaatttc atattgcttg tatccgagag aatcaagcat ttcaacagct
      361 ttcagataca tttcagcctg catatcatca tcggcaagct taagtttatt ttgcacctta
      421 taaaacggag tattctcctc aattttcaaa atgtatgatg aaatatgagt aactttgcaa
      481 tcggcacaga aactgattga tttttcaagg ctttcaattg tctgattagg gattcccatc
      541 atcaaatcaa gtgaaatatt attaaatccc gcacttttag ccctttcaac agaagtcttt
      601 gcatcatcaa tgctgtgaat tctcccaagc agccttaatt catcttcaac agcagtctgc
      661 attcccattg aaatgcgatt gaatccgcag gcatacattt tttcaaaatc aatagttttg
      721 gcggagtcgg gattgacttc aaccgtaatc tcggcattat tttgaatatt aaaattaaac
      781 ttgataaaat caagaatatc acaaagtctg tctgcaccca aaacactcgg cgtaccgccg
      841 ccgaaatata cggttgcaac atctcttttg gctttttcag accagtattt tattttatct
      901 tttaattcaa tcacataatt atcaaaagct ttttcatctg cattgccgct gaaaaaatcg
      961 caatacggac atttgtgctt acaaaacggt atgtgaatgt aaagaccgat agaattactc
     1021 ataaaaaacc tcataaatga ttttgaggca gaaacacaag tttctgcctc gatttggaag
     1081 gtatatgaaa aaataggaaa aatcacatta agtccttctg taccaatata ttacaatata
     1141 tttacaaatt tgtcaagttt ttgtagcaat tatttttctc acattttctt cattctttat
     1201 tgacatatac catccaaaaa tagtaaaata taaaattgtg gatatactta acctccgaag
     1261 ggaagaaaga tatgagttca tttaaagaag aaatcagcaa gcgcagaacc tttgcgatta
     1321 tttcgcatcc tgatgcgggt aaaacaacac ttacggaaaa gctcttgctc tacggcggag
     1381 caattaacct tgcaggttcg gtaaaaggca aaagaaccgc aaagcatgct gtgtccgact
     1441 ggatggaaat tgaaaaacag cgtggtattt ctgttacatc atcggttttg cagtttaaat
     1501 ataacggtta ttgcataaat attcttgaca caccgggaca tgaggacttt tcggaagata
     1561 cctaccgtac acttatggcg gcagactctg ccgtaatggt aattgacggt tcaaaaggtg
     1621 ttgagaaaca gactatcaaa cttttcaagg tctgtgtaat gcgtaatatt cctatcatta
     1681 cattcatcaa caagatggac agagatgcaa aaaattcttt tgaccttctt gaagacattg
     1741 aaaatgttct cggaattcac acctatcccg taaactggcc aatcggttca ggtaaggaat
     1801 tcaagggtgt gtatgacaga aattctaaga aaatccttgc tttcaccgct aataacggtc
     1861 agaaagaagt tgaaaagaaa gaacttacgc ttgacgaccc tgcccttgaa gatacaatag
     1921 gctactatca taagcaggat ttgtttgatg aaatagaact tcttgacgga gcaggcgatg
     1981 aatttgacct tgaagcagtc cgcaacggtc agcttactcc tgtattcttc ggttcggctc
     2041 ttacaaactt tggtgttgaa ccattccttg aacagttctt acagctcaca actccacctc
     2101 tgccaagaga aacagttaat gaaaaggttg agcctatgtc agactttttc tctgcatttg
     2161 ttttcaaaat tcaggcaaac atgaataagg ctcaccgtga cagagttgca tttatgcgca
     2221 tctgcagcgg caagtttgaa aagaatatgg aagtgttcca tgttcagggc aacaaaaaaa
     2281 tgcgtctttc acagccacaa cagattatgg ctcaggaaag agaaattgtt gacgaggcat
     2341 atgcaggcga catcatcggt gtgtttgatc cgggcatttt ctcaatcggt gacacaatct
     2401 gttcaccggg ccacaaggta cagttcaggg gaattcctac atttgctccc gaacactttg
     2461 cacttgtccg tcagaaagac acaatgaagc gcaaacagtt catcaagggt acaagtcaga
     2521 ttgcacagga aggtgcaatt cagattttcc aggagcttga cgcaggtatg gaggaagtta
     2581 tcgttggcgt tgtaggcgta cttcagtttg atgttcttaa atacagactt caaaacgagt
     2641 acaactgtga tatcattatg gaaacactcc catatgaatt tatccgttgg attgtaaacg
     2701 atgacattga tccgaaaact ctcgaccttg cgtccgatac taaaaaaatt caggatctaa
     2761 aaggcaatca tcttttgctc tttacaagct actggagcat aaactgggca cttgaacaca
     2821 acaagggact tgaactcgct gagttcggca caaactaaat atttaaaata tcggaggata
     2881 tatgctttac gacaagctta aaaattattc aaaaagcggc atatatcctt ttcatatgcc
     2941 cggacataag agaacggaca ttacagaaga gggtataata ccgtataata tcgacataac
     3001 cgaaattcat gattttgaca atctccattc gccaaacgga gttattgacg aaattcagaa
     3061 aaaggctgca aagctttaca atgcaaaaaa tgctttcatt atgattaacg gttcaacagg
     3121 cggaatactt tcagcaattc gctcaatgac aaatcaaggc gacaagatct taatggctcg
     3181 taactgccac aaatctgtat ataattcagc agaactgttt gatctcaatg tcgattacat
     3241 ttttcccgat acagacagca gatataatat tcttacatcg gtttcacctt gcgatataga
     3301 agataaactt acaaaacaca atgatgaaat cagacttgta atcataactt cgcctacata
     3361 tgaaggagtt gtttcggata taaagtcaat ctccgaaatc tgtcacaaac acggagcaaa
     3421 attacttgtt gacgaagctc acggagcaca ttttccgttt tcggacagtt ttcccgatga
     3481 agcacttaac tgcggtgcag acgccgcagt actgagtctg cacaaaactt tgccgtcatt
     3541 aactcaaact gcattgctca taacaaatga cagcgagctt tctgaaattc ttgccgaaaa
     3601 tttggctgta tttgaaacaa gcagtccgtc atatatttta atgagttcaa tcgaaaaatg
     3661 tcttgatttc tgcgaaaaca gcaaagataa attcaaggaa tattgtcgca atcttaaaac
     3721 ggtcagagaa aaacttaaaa atctgaaata tctgaaaatt tatgataaaa gcgatactga
     3781 ttttgattat gatatcggca aaattgtaat ttcaacagcg aacgcaaata tttcaggaac
     3841 aaagcttgcc gaaatactgc gaaataatta tcagattgaa accgaaatgg catattcgga
     3901 ctatgtaatt gccatgacat ctgtttgtga caccgaaaaa ggctttgata tgctttcaga
     3961 tgctctgatt tcaattgaca gcgaactttt aaaagaagcc gacaccgagc gtgttccgtt
     4021 aaaaaatctc tacacaggca aaaatttcaa cgcctgcgag ttgtacaaat tcaacaaaga
     4081 aactattccg tttcaaaatt cggaattcag aacttctgcc gagtatatct gggcatatcc
     4141 acccggaatt cccctcatcg tacccggtga aattataagc aaggaactta taaattacat
     4201 tgaatatctt tcagcctgca aggttgagat tatgtcaaca aaaggcggta tgacggacaa
     4261 cataagcgta gttaaaaaag attgacaaat caatgactgt gtgataatat taaactaaca
     4321 aaatctaaca aggagtttga tttattatga agagaattaa aactatcgaa actcgtgacc
     4381 ttaagaagag cgttaagaca ggcggttgcg gcgagtgcca gacttcatgc cagtcagctt
     4441 gtaagacatc ttgcggcgtt gctaaccagc agtgcgaaaa gtgcatgagc gagaaataat
     4501 tctattttaa tttgattatt aaggattatc gccgttttcc caaagggtta acggctttcc
     4561 ttttgtctaa cggagatatt atgattcatc agtataaact taacggatac aacatagttc
     4621 ttgatgttta cagcggcagt gtacacgcag tcgatgacct tgcttatgat gttattgcaa
     4681 tgtacaaaaa cgcaacaaaa gaacagataa ttgacgaaat gctttcaaaa tatgcagaca
     4741 atcctgagat tacaaaagaa gaaatctctg actgcattga tgatgtaaaa gagcttgagg
     4801 aacagggaaa gctctttaca gacgacaagt acgaaaacct tgcatttgac tttaaaaagc
     4861 gaaacacagt aattaaagca ctttgtctgc acattgctca cacctgtaac cttaattgcg
     4921 aatactgctt tgcaagtcag ggcaaatacc acggcgagag agcgctgatg agctttgaag
     4981 tgggcaagag agcaattgac tttctcattg aaaattcagg cagcagagta aaccttgagg
     5041 ttgacttctt cggcggagaa cctcttatga actttgatgt tgtaaagcag attgttgcct
     5101 atgcaagaag cattgaaaag gaacacaaca aaaacttccg ttttacactt acaacaaacg
     5161 gtatgcttgt tgatgacgat gtaattgaat ttgcaaacaa agaatgtcat aatgtagttc
     5221 tcagccttga cggcagaaaa gaagtgcatg accatcttcg caaaactgta aacggcaagg
     5281 gcagttatga tattatcgtt ccgaaatttc aggaatttgt caaaaaaaga ggcaacaagg
     5341 gttactatgt aagaggtact tacacacata ataacacaga cttcacaaac gatattttcc
     5401 atatggcgga tttgggattt acagagcttt caatggagcc ggttgtatgt gctcccgatg
     5461 acccatatgc acttacatat gacgatttgc ctgttctttt tgagcaatac gaaattcttg
     5521 caaaggaaat gctcaagcgt gaaaaagagg gcagaccgct caccttctat cattacatga
     5581 ttgaccttac aggcggtccg tgcatttata agagaatctc gggttgcggt tcgggtacag
     5641 aatatatggc tgtaacacct tggggcgacc tctatccctg tcatcaattt gtaggcgatg
     5701 aaaagtacaa gctcggcgat atctttaacg gtgtttcaaa cacgaaaatt caggacgaat
     5761 ttaagctttg taacgcatac gcccgtcccg actgcaaaga ctgctgggca agactttatt
     5821 gcagcggcgg ttgtgccgca aacgcttatc atgcaacagg ctcaatcaca ggtatttacg
     5881 aatacggctg tgagcttttc agaaaaagaa tggaatgtgc cattatgatg aaggttgcag
     5941 aagcggaaga ataaaattac aataaaattt acaggcagat acatttttct tgtatctgcc
     6001 tgtattttcg aggtgctgta tgaacgaaaa aattattatg ctcggcacag gaagtgcgat
     6061 ggttaccgac tgttataata cctgttttct tctgaaatcc gaaaacgact gtcttcttgt
     6121 tgacgcaggc ggcggaaacg gaattttatc cgcaattaag aaatccggaa tagcttggaa
     6181 cagcataaag acaatgttta tcactcattc tcacaccgac catattttag gcgccgtgtg
     6241 ggtaataagg caaataagcg ctcttatgaa ttcaggcaaa tatgacggta attttaatat
     6301 ttactgccac gatgaatgtg ttgattcaat cacggcaatt tgcaaccaca cactggcacc
     6361 gaaatttctc aaaaatatca atacaaaaat tttcattaat gaagtaaaag acggtgaaaa
     6421 gcaaaatgcc ggcagtatcc gactcacttt ctttgatata ttttcagaca aaacaaagca
     6481 attcggattc aaggctgttt ttccgtcagg aaaagttctc gcctgtctcg gtgatgaacc
     6541 gttcaatgaa aaatgcagaa attttgttca aaactgtgat tatcttatgt gtgaagcttt
     6601 ttgtctttac agtcaaaaag atatttttaa gccctacgaa aaattccaca gcacagcgct
     6661 tgatgccgga aaacttgcag agagtctttt tgcaaaaaat cttatcctgt atcacaccga
     6721 ggacgaaaca cttcgaacac gcaaaagaac atacacttca gaggcaggaa cagtttttaa
     6781 cggaaatata tttgttcccg atgattttga agttattgac ttaaaataat ctcataacac
     6841 ctgctgtaat catacaaagc acaattccca ttgcagtagg caaagccata gaaacaagcg
     6901 tccatttaag gctgcctgtt tcttttttta ttgtcagaca ggttgttgaa cacggataat
     6961 gaagaatgca aagaataatc gtgcatacag ccgttgtaat cgtccagccg ttcatactga
     7021 gtagctgaaa cagctgatcg tagcttgaat aatcaacaag agtaccgctt gccatatatg
     7081 acataattat aatcggaata acggtttcat tcgcaggaaa tccaagtata aatgccatta
     7141 ttataacacc gtcaaccccg ataaatcttc cgaacggatc taaaaagtca gtacaatatt
     7201 tcaagagtga aacatcgctt atatgcacat ttgcaagaat ccagattatc gcacctgccg
     7261 gagcggcaac cgcaacagcc cttcctaaaa caaataaagt tctgtccaac agcgaacgga
     7321 cgatagtttt taaaatctgc ggttttctgt acggcggaag ttcaagcaca aatccggact
     7381 gttcgccttt caatattgtg actgaaagca ccttagatat aacaagtgtt ataaaaacgc
     7441 agaaaactat tattccaatc aacaatgccg ctacctcaat cgaactgctc agcgtaaatg
     7501 ccgtacctgc aaagaacatt agcagtaatg caataattgt gggaaaccgt ccgttacacg
     7561 gcataaaatt atttgtaaga attgcaatca gccgttcctt gggcgactca ataattctgc
     7621 atcccgtaac tccacaggca ttacagccaa gacccattgc cattgtaagg ctctgctttc
     7681 cgtgagcacc gcactttgaa aaatgcctgt caagattaaa tgcaattctc ggcagatatc
     7741 ccgaatcctc aacaagcgaa aatagcggaa agaatatagc cataggcggc agcattacag
     7801 ataccaccca tgacagagtt gtataaactc cgtcaatcaa aagacccgtt acaacatcgg
     7861 gggcgtgtaa aaaatcaaaa agaatataca gtttctcttt tataaagcca aacaaattgc
     7921 ttaaccattc gctaggataa tttgcaccga caaccgttat ccagaacaat ataccaagca
     7981 ttgcaagcat aatcggtatt cctgcggttt tgcttgtaag tattttatca agctttcttg
     8041 tacaagcatt taactctgat ttttcatatt ttacacagtc atttgaaatt ttgctgccag
     8101 tctgcgaaag cttttcaata ttctgtttgt agtttttttc ggatagtata tcaacacctt
     8161 caaaatttct ttttacccta aaacattttg tctttccact gcatacatca tagattgctt
     8221 cttttaattc atccagacct tttttgtctg ttgcacaggt ttttacaaca ggtattccga
     8281 ggttaagcga taactcgtcg cagtcgattt ttatgccgtt cttttcagcc tcatcacaaa
     8341 gattaagaca aagaacagca ttctttgtga cagataatac ctgcaatgca aacgaaagat
     8401 ttctttcaat aactccgcag tcaacaacta ttacaacgca gtcattttga ttttgtataa
     8461 gacaatccct tgttaccgcc tcttcgcccg aaaatgaaag cagggaatag catcccggta
     8521 agtccgtaat acaaaatctt gcgtctttga ttttgcaact gccttttgca aaatcaactg
     8581 ttttgcccgt ccagtttccc gtgtgctgtc ttaatcctgt cagctcattg aaaattgtac
     8641 tcttgccgac attaggatta ccggcaagtg aaattttgta atcgcaatcc gatacatcct
     8701 ttttattaaa agatgattta tccgtagaaa acaataaaaa gcctcctttt attcaggagt
     8761 aacaatgata tttttgcaat cgttatttct cagtgccaca acggcatttt taacaagata
     8821 cgcagacgga tcaccgaacg gacttgtaaa taagggaata acaggactgt tctccataat
     8881 accaaaatca aatattctgt ttttgatatt ttcattacag ttcacacgat agacaatccc
     8941 cgtaactcca agcggtaact tgtcaagcga acatttttct ttcatctgat tcaccgattt
     9001 caacttttta ttaacagcat attcaattca tacaactgag ttacacaaaa agccggccat
     9061 aaactaaact tatatcgtac ctgaataaac tctgatatca gaaaaatttt aaggaattga
     9121 cacgactata aacaggtgtt ataattaaat gcagatttca aatgtatata acttaatatg
     9181 ggtttacggt tcaaaatgca tcttgcagag tagataacag agaattcggt gagaatccga
     9241 agcaacagtc attactgtat ttggcattgc cataagtcag gtcgctgtcc gtatacctcg
     9301 gattttgcaa atcttggaca gggaagaggt gcagccgacc atatctatac agacttttgg
     9361 cctgtatggt tttgtttgtt gtgccttcca aaacggaagg ctttttattt tgcctttcga
     9421 tatacacaat acaatatgga ggaaaacatt atgaacaaat cttttaaaaa aatcctctca
     9481 attgtacttt ctgtaatgat gatttcgtca cttatgacgg tttcactttc agtaagcgca
     9541 gttgaagacg gaaaagtaag agtaattgtc agaaatgata catactcagt agaaaacggc
     9601 gctccgtggg acggcgttct cgttgacgag tgggtaagca ttgataatga ctctactatg
     9661 atgtcagcgg ttgttgacgc actcaacaat cacggttaca cacaggaggg tgctgagagt
     9721 aattacttct catcaataaa cggtcttgct gcatctgacg gcggtgcaat gagcggttgg
     9781 atgggaacac tcaacgattg gtttacaaac tacggtttcg ctgatattac cgttgcaagc
     9841 ggcaaccttg agagcggtga cgaaatcgct attatgtata cttcaaacgg ttacggcgag
     9901 gatatcggcg gtacatgggc aaataacgat acaactgtta aatcggttga aatcacaggt
     9961 gccgagctta caggcaaatt tgatccgtct gtaacagact atacacttac aatcggcaca
    10021 ccgtcagctg atgtaaatgt agttcctact gcaactaaca aaaacttcca gacaagaaaa
    10081 tataagaatg aatatcttcc ttctgacgac agtgcgtttt acaagagaag tcagacggtt
    10141 aatgtttctg acggtgacaa aattatcata ggttgcggtg atactgcatg gccgtcaatg
    10201 aacacaagtg aaggcggtac tgtgtataca ttcacagtga aatatgctcc ttccgcagct
    10261 gatacagttt caaacaagat tgacgaggtt gcaaaatatc ttgcatcaca agatgccccc
    10321 acagtttctt cggtaggcgg cgagtggaca gtcctcggtc ttgcaagagc aggtaaaatc
    10381 acagacgaaa ttgcagacag ttactatcag aatgcagtta agtatgttga agaaaagggt
    10441 tctgcaaaac ttcacaatac taaatcaaca gacaattcaa gagtaattct tgcccttacg
    10501 gcaatcggta aggatgttac ggatgttgca tcatataatc ttcttgaacc gcttgcagat
    10561 atggattatg ttaagaagca gggtatcaac ggtcctgtct ttgccctcat cgcacttgat
    10621 acgggcgatt atgaaattcc gcagactgac gccgcaaatc ccacaacaag agaaaaactc
    10681 gtacagacaa ttcttgatgc acaggtagca aacggtggct ggacattctt cggtaaaact
    10741 gcagatcctg atatgacagg tatggcaatt caggcacttg ctccttacta ttcatcaaac
    10801 agcgatgtta aagaagcaat tgataaagca ctcacagtaa tgtcaaacgc acagaatgaa
    10861 aacggtggat ttgcatcatg gggttctgta aacagcgaaa gctgtgcaca ggtactcgtt
    10921 gcacttacaa gccttggaat tgatcctaca aatgatgaaa gattcatca
//
