LOCUS       gnlProkkaHGHCECKN_153  14033 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HGHCECKN_153.
ACCESSION   gnlProkkaHGHCECKN_153
VERSION     gnlProkkaHGHCECKN_153
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 06:20:24
            Original ID  :: gnl|Prokka|HGHCECKN_153
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14033
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14033
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3975:4326]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3976..4326
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14033
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14033
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             983..2494
                     /locus_tag="ctg153_1"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYST
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWQLVSE"
     CDS             2568..3635
                     /locus_tag="ctg153_2"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKMPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             3673..3957
                     /locus_tag="ctg153_3"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(3976..4326)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg153_4"
                     /sec_met_domain="PqqD_RRE (E-value: 9.8e-12, bitscore:
                     34.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.6e-18, bitscore: 55.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVV"
     CDS             complement(4424..5812)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg153_5"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(6062..6457)
                     /locus_tag="ctg153_6"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             complement(6464..7237)
                     /locus_tag="ctg153_7"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQPAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(7243..7770)
                     /locus_tag="ctg153_8"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(7757..8998)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 386.9; E-value:
                     2.3e-117)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg153_9"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQVGTVVTTPVVTTHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(9008..10102)
                     /locus_tag="ctg153_10"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(10107..11147)
                     /locus_tag="ctg153_11"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGSADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQNQIPLGEASKE
                     AEQTNK"
     CDS             complement(11166..12176)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg153_12"
                     /sec_met_domain="PF04055 (E-value: 1.7e-18, bitscore: 57.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVELQSLTKRLDMPGFAAKQIASWLYEKKVASIDDMTNLSLKH
                     RELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATLCVSSQVGC
                     KMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNLDEVLKALE
                     LLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAELMPAEKAF
                     SITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRVNLIRFHAI
                     PGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEKNNES"
     CDS             complement(12304..14031)
                     /locus_tag="ctg153_13"
                     /transl_table=11
                     /translation="MTLLMLSLTLEGFTEDEVKSMADINQILWSQLRVEMSSWLTNKGG
                     RYCIGDTQMVEAIERYFAQDDECIDDSRHEIISALLDEEEILSHPLTFADYNYRMKQFC
                     YHDSYRYKVEITYQCYKMQEWDILKDWICDVEIFEILYRTNRSLLEDSWKAIMNDNPEV
                     TPEVYAELDFDEIDSFLIPVIANDMATFLSSSFHLTKAAAAVSEKSMEGAAMPLIAKSV
                     LKMNEGCRYARNEEYETACDCFLKALVMQENIVPTPELEIANTCRNLALAYYYNEQYNE
                     AVIYLNRALDYHAASADEKSQAEVIELSEYLAYCDYYKDEEESAAEKFRKVAEMHESLN
                     GRLSGGVAKCLRMQGKCLYYIKRYDEAWMLMNQALDIAIQIDNKKQIVACHKQLYYLCR
                     EFKRMMNERGDEQASTLFFRESLLHEMCFSEKPRLAELTVRYEALRCDIMQQYYMNKDY
                     DNVIRIATSLDIHDDADPNASCLVYYYKAQAYVKLENYPMAKEAFFREFELRKKYLGWE
                     EEDTILACQNLGVLHSFCNEREEALACFREAYGHEVKKNGEDSEMAQKLLQYISVVES"
ORIGIN
        1 tctatctcca aagataacat ttttatcgga aacggcaaat aatcaaaggc ttaatcaggg
       61 gaaccgcatt aaaaatttgt ttaagaaggt atggagataa actaaacaca atttccatcc
      121 gcccctctac agaaaaagat ttttcatttt catttctcat attctcataa ataaggcaca
      181 agtggcagta aactaataag atagactatg agaaatgatt ttaaaacagg catttctcat
      241 agtttcttcg caaaataacc cggattttgc ttcatttctc atagtgtagt gtgccggaag
      301 ctgacattga ataaatagaa ctatgtattc cttttgcttg cttccataca cagtgtctta
      361 gtcccacata ttgtgggaaa agattcccta aggcttggga aagtattccc ttattttgtg
      421 ggaaagtttt ccttcaatat acgagaatac tttcccacaa tatatgggac aatcgagaac
      481 aacgagcatc tccaagcaaa aagccactat tttatctaaa tagtagcttc atttcctgat
      541 aaaaataagg caggctgaaa gaaaaaagga agaaagaatg gcttttgact atgagaaata
      601 ccctgaaata cgatgagaat aaggtggctt ttgagccaaa atatgggaga acttatgaga
      661 aataccgttt tgaaaaagtg tttctcataa gatatctatt tgattatctt tcgtttatcg
      721 aaaaacaatg agaatatgag aaatgaaatg aagaaatctt tttcaggaag aaataaaagt
      781 aagttcataa tggtgcagca ttgaattatt ttttggcgga gttattctaa cacttaatag
      841 ttcaaaagca gatatttctt tgaccaaaag atagaactaa tgatgaatta aaagttgcaa
      901 ttatggtttt cttcccacaa caaacgggaa aagtcagaag aatcatgtac atttgtaatc
      961 cgaaaactaa aagaacatcg caatgaaaat atttccaagc agcagtatca agaaattgga
     1021 cgcttatacc attgagaacg aacctattgc atcaatcgat ctgatggaac gtgcagcaac
     1081 cgtattaaca aaagccatca cagacagatg gaatacggaa acgccggtca ctatctttgc
     1141 cggaccgggg aataatggcg gagacgctct cgccgtagcc cgcatgatgg ctgaaaaagg
     1201 atataaaatc gaggtatttc tcttcaacac gaaaggagaa ctttcacccg actgccaaac
     1261 caataaagaa ctggtagaaa tgatggaaga agtaaaattc cacgaaatca gtacccaatt
     1321 cgtacctccc gtcctgacgc ccgaccatct ggtaatcgac ggattattcg gttcaggcct
     1381 gaacaaaccg ttaagcggcg gattcgctgc cgtagtgaaa tacatcaatt cctcccctgc
     1441 tatggtagta gccatcgaca ttccttccgg actgatggga gaagaaaaca cattcaacgt
     1501 aaaagctaat attatccgtg ccgacgtaac tttcagtctg caactgccga agctcgcctt
     1561 tcttttcgca gagaacacgg aatttgtcgg agaatgggaa gtgctggaca tccaattaag
     1621 cgaagacggt attgaagaga tggaaacgaa ctacgaaatg ttggaaatag agcaaatccg
     1681 ttcactcatc aagccacgca aacagtttgc ccacaagggg aacttcggcc atgcactatt
     1741 gattgccggt tcaaaaggaa tggcaggagc ctctgttctc gctgcccgtg cctgcctccg
     1801 ttcgggagta gggttgctga ctgttcatgc gccaatgtgc aacaacgaca tcttgcagac
     1861 ctccataccc gaagcaatcg tagaaaccga catcaacgaa acctgttttg ccgtacctac
     1921 cgacacggac gactatcaag cagtcggcat cggcccaggg ctgggacgaa acgaggaaac
     1981 ggaagctgct ttattggagc aactggaaca ttgccagact cctgttgtgg tggatgccga
     2041 cgcacttaat atcctcgcca accaccgtca tgcacttacc cacctgccga agggttccat
     2101 cctcaccccg catccgaaag aactggaacg tctgaccggc aaatgccagg actcttacga
     2161 acgtctgatg aaggcttgcg aattggctcg tgccgcccat gttcacatta ttttaaaagg
     2221 agcctactcc gccattatca ccccagaagg taaatgtttc ttcaacccaa ccggaaatcc
     2281 gggaatggca accggaggta gcggtgacgt actgaccgga gtaatcctgg cactgcttgc
     2341 ccaaggttac tcaaccgaag aagccgctaa aatcggcact tacattcacg gattggcggg
     2401 cgatgtcgct caaaagaagc aaggaatgat cggaatgatc gcaagcgata ttatcacctg
     2461 tctgccgaca gcatggcaac ttgtaagcga ataaaagtta agaacttacc cttttttcaa
     2521 taacttcatt aactttgttt tcaaaaccag ttaaaaaaga accgaatatg aaaaagttga
     2581 ttatagcagc aggactacta atgacaacgt ccgcctatgc acaaaccgaa gtactgacag
     2641 gggttacccg aggaaaagac tatggagtgg tttacagtct tcccaaaacc caaatagaac
     2701 ttgaaataaa agccaacaaa gtcaactata ctccgggaga attcagcaaa tatgctgatc
     2761 gttacctgcg actgaccaac gtctccgccg atcctgaaga gtactgggaa ctggctagcg
     2821 taaaagtgaa atccgtaggt gtgcccaaca gcgaaactac gtatttcgta aaattgaagg
     2881 ataagacagt agcaccgctt atggaactga cagaggatgg cattgtgaaa acgatcaatg
     2941 ttccttacag caatagcagt gtaggcaaaa aagctgctcc cgcccccgca gtcctccaaa
     3001 agaaagcgaa tcctcgcgaa ttcctgaccg aagagattct gatggctagc tctaccgcca
     3061 agatggccga gctggtggct aaagaaatct ataacatccg cgaaagcaaa aatgccttat
     3121 tgcgcggaca ggctgacaat atgccttcag acggagcaca gcttaagatt atgctcgaca
     3181 atctgaatgc acaggaagaa gccatgacgc aaatgttctc cggcacctgt aacaaagaag
     3241 agagaacatt cactgtccgc cttacccctg acaaggaatt caacaatgaa gttgctttcc
     3301 gcttctcgaa gaagttaggt gtagttgcca acaatgattt ggcaggaact ccgttttata
     3361 tcagtctgaa agacctgaaa tcggtcaaga tgccacagga agatggtaag aagaagaaag
     3421 atttggatgg aatcgcctac aacgtacccg gacaagctat ggttacactg accgacggta
     3481 aaaagaaact ttacgaaggt gagcttccta ttacccaatt tggtgtgata gaatatctgg
     3541 ctccggtttt gttcaacaag aattctacca tcaaagttta ttttgatccg aatacgggag
     3601 gattgctcaa agtggacaga gaagaaggga aatagaaaaa cgaaggaagt gaacttctaa
     3661 aaaacaaaga atatggttgg tgaaggacat gcattcgaca tgatacgccg aataaaagag
     3721 ggacgggaag cttcccgcct acgtcgtgaa cgtgctaacg ataagttgaa gcatctaaac
     3781 cgtgcaaacg aaccttatcc actacccaac accacccccg aagaaatgga acgtatcatc
     3841 cacgactcgg agaaaaagaa agagaaagac agcaattatt ttgtttgggg aacgcttatt
     3901 atcatggggg tcctgatagc aattgccgtc atactttggg ctgtatttat caaataaata
     3961 ataataagtt cctatttata cgactggtat caccagtttt ataaatccat ctttctgcat
     4021 ttgagaaaga taagccgata cacgcgactc gtagccctct tcattttgaa agtggtctgc
     4081 gagtttttct ataatctcac gaacattgcg ttttccatct atcagttccc atacagccgt
     4141 accgtgttct tccaatttca catgaagttc tttcgacatt ccttttggca caaggaagcg
     4201 ttgcatccac ggatatttaa aacggggaaa ggagagcaca attgtctccc cttccctttc
     4261 tgctgtaata tgttcactgc gacagggaat gacctctaac aggttgattt tctctttggc
     4321 agccatactt cttatttttt atttcagagt attcatactg atactcttct gtttacacct
     4381 tgatacaaaa ttcctttgtt actttaggta ttgaatttcc tagttacttt tggatattcg
     4441 cctcttccaa accgtatccc ttcttcttgt tctctgcctt caacatcaaa gccacaatca
     4501 gagcaagcac accaaagaga gcaaaaatag ccatcggcaa cgtgtaatca taagtctgtg
     4561 caccgtctac taccggacct ttgcaataag tattcaacac ccatccgatc aacaaaggaa
     4621 cacccatcaa tccccagttc tgtacccaga aaatcaatgc atatgcggta cccaactgtt
     4681 tttccggaat aatcttcgga acagacggcc acatagctga aggcaccaac gagaaggcaa
     4741 atcccaatat aatcatgatg atagtagcaa accaccatat attcagtata ggcagagcaa
     4801 acatcgtatg cacaaaaata agcatcactg atccgattat catcaatgtg gctcccttac
     4861 caatacggtc ataaagcgag ccgaacaacg gagtcaggat aatcgcacca atcggcaaca
     4921 atccgggaat cgttcccgcc aacttcggat ctacgttata cttctgcacc atcaagtcgg
     4981 cagcatactt gataaagggg aatacagccg agtagaacaa tacacatagt aatgcaatca
     5041 gccagaatcc tttattggta atgatataca caatatcttt catacggaac ggctcttccg
     5101 gctccaatcc ttctgcatcc aaagaagcat ccaacttctt atcatagaaa gtataaagga
     5161 agaaagcaat cgtacccacg cacaacataa tcagacaaaa caaaatcgga gcaggaatat
     5221 tggtatgaaa tgtgccactc tcatccgtag atccgaaaaa gtcggccaaa ggaaccgtga
     5281 gcaccattgc cagagttgtt ccgatacgtg ccgtagccat ttcaagtccc atagccaatg
     5341 ccatttcctt acccttgaac catttcacga taattttgga aactgtgata ccggcaattt
     5401 ccacacctac accgaagata gcatacccca atgcagccag ggttacctgt gttttgaatc
     5461 cgaagagcat ggcaccttcc ggaaaagtag tagaaatcgc atagtatttc aatccacaac
     5521 caaacaccat caataagcaa gctcccattc cggtaaaacg aactcccatc ttatccaaaa
     5581 tgataccacc gaaaatcagc atcaatagga atacattaaa ccacccgtaa gcacttgtga
     5641 agaaaccata atcaagactg tcccatagta gttctttctc aagcatgggt tttagaggag
     5701 acattacgtc ggtgaggaaa tagccgcata gcatagtaaa tgcgaccaat gctagaacac
     5761 tccatcggag tacggcggag tcattcaatt tctgtttcaa atgttctgtc attgttatat
     5821 ttaaaaatag tagttaataa tcttcatacg accaacaaag gtagttaaat ctcgtttgtt
     5881 tctatcaaaa agagattgtt tttacaagaa aaagttaagt gcggattaca ctgaccacgc
     5941 ggaagattga aaatccgtgt aatctgcgta atccgcactt aaatatcaaa gaaatgcagc
     6001 atccgtctgc accttcccat taatggtttt accccaaagt cttacctgac aacggagtga
     6061 attactctgc tgcaggagca ggagtttcag tagccggtgc cggagtttct gtagcaggtg
     6121 cattggtagc aggagcttca gtttgcggcg cagccgtacc tgcgggtaag ttatacgggt
     6181 tagtctgttg ttctttctgt gcctgttcca acactgcgtc tttagcaaca gcagagcgag
     6241 gaactacata agcagtagca atgctcatta ccaccatgaa gatagctaag ccccatgttg
     6301 ctttttccag aaaatctgta gtcttgcgca cgcccatgat ggcgttagat gaagagaaac
     6361 cagaagcaag tccgcctcct tttgagttct gaatcagcac gatgaaacac atcaacaagg
     6421 ctgcaataac cattaagata acgaataata agtacatttt tagttatttt gaattagcgt
     6481 taataatcaa tttctccaaa aatctgattt ggtctgcaaa gtaagcattt ttttttggat
     6541 atttcaagct taatttttta attatttcaa gagcttttga atatcgttgc tgtttaacat
     6601 agatttttgc caaagtttcc gtaaaacagc tgtcatcttc ctcttcttcc ttcatcgttt
     6661 cttcttcggt aagttcgtcc gaagaggttg gcgaagatgg catttcttct cttaaaggtt
     6721 tcttgcagag gggagagtcg ctctcgctct tttctataaa gtcgtcaatc agttcgtagc
     6781 ctttgagttt gggcgtttct tcggccggct gttccgtggc cggagtctcc tccaaaagat
     6841 aagaggtgta atccatcgaa tagtcgaagc tggtgcgggc agtcacctct tcgggtactg
     6901 tggacaagaa agcgtcgatc aatgctaatg tgcggtctac ggacggttcg tctttcagca
     6961 cctccgtgag aggtactccc tttttccgtg cctgcacatc atagcggtca ccttcaatca
     7021 accggaacaa ctgccgtctg tctgcaatgt aaagaactgc tttccgcagt tctccaccaa
     7081 aactaatatc atggagaata tacagattct tcagatacag cagacgaagt gactgaaaat
     7141 acggatacct cgcaagaaga ttgcgcagtt cgtacaaagt atccctattc agcgtctcgg
     7201 gatgctgaat ccattgttga aagttaacag aagtcattta tattaccagt ttgctacagt
     7261 tgcattaaaa atttggtcgg tgatctcttt agacatttca gcaatcaatc cgtcctgtac
     7321 ggcagtcagc aactggctag agtcgtaggt acggaacgca gaaaactgtt gttcaaagtc
     7381 ttcggcatga ttggtgttgt tgacaaaacg tacattaacg gtgatagtca acttcgtctc
     7441 cgaagaataa ccgtcggcag atacagcctg attgtactga ttgtaacctg tgatttctcc
     7501 gtcaatctgc aagtcggcat tttgactcgg cttgagcagt tgcagacggg tctgccggat
     7561 gaagatatct ttcaggtcct cattaaactt ggttgccaac ggagcataca catactccga
     7621 cttgatcggg aagtcggcta tcgaaatggt ctttacctta tcataattga tagacgatcc
     7681 gttaaactta taggaaacag tgcacgcaat gactaccaac ggcaagccga acagtaacaa
     7741 agggcgtatt attttcttaa tccaattcat attcttttat ttttctatag agtgtacgct
     7801 cggaaatatt caagtccttg gccgcactct tccgctttcc atgatgcctc tcaagtgctt
     7861 tgcgtatcat ttctttctcc acttcgtcca gtgacaaagg agattcttct acatattctt
     7921 ccgtgtcttg tatgtcatca tcatccttgc aaaccgtggg ctgcatggtg tgaatgatag
     7981 caggtaccga aggctggtgt gtcgtcacta ccggagtagt aaccaccgtt cccacttgtc
     8041 ctacctgccc cacctgtccg gcacgttccg ccatcaggtt gtgcaccatc ttcttcagct
     8101 ccgccacttc ctggcgcata tcgaacagaa cagaataaag aatctcccgt tcgctctcaa
     8161 agcctttact ctcacgcgtt cccatcagcg cgggaagacg ttgcgtattt tgtgcaggaa
     8221 gataattctg caagatagca gcagagatct ccctgttggt ttcaatgata gatatttgct
     8281 cggtgatgtt cttcaactga cgaacgttgc cgggccacgg gtaagccaat aactctttct
     8341 tcgcatcctc cgtcaactgg atagcaggca tccggtattt ctctgcaaag tctgcggaaa
     8401 acttacggaa caacaaaagt acatcgtcac cacgttcacg caaaggcggt atttggatag
     8461 gcaccgtatt caaccggtaa tataaatctt cacggaaacg tccttctgca atcgcttgtg
     8521 tcagattgac attggtagct gccacaatac gaacatccgt cttttgcact ttggacgaac
     8581 ctacttttat aaactcgcca ctctccaaca cacggagcaa acgcgcctgg gtaggcatcg
     8641 gcaactcccc tacttcatca aggaaaatag taccaccgtc ggcttcgcca aagtaccctt
     8701 tccgttcgcc aatcgcaccg gtaaacgcac ccttctcatg cccgaacagt tcggaatcaa
     8761 tcgtgccctc cggaatagca ccacagttga cagcaatata ctgtccatgc ttcctccggc
     8821 tatattgatg aataatctgc ggaaaacttt cttttccgac tccactttct ccggtaatca
     8881 gcacagacaa atcggtagga gctacctgaa tggcaacatc tatggcgcgc gacaatgctt
     8941 cggtatttcc aataataccg aaacgctgtt tcacttgttg tatctctgct ctcgtcatca
     9001 ctcgttttta atcttcgtct actgtatcca gcttcagttt atcactatcg tcacgtttct
     9061 cgtaatactg tttacgcaac ggattggcac gagccacttt ttcccgctga cgattacgga
     9121 acacatcgat ggcaacatag attgcctgac ggaaagaatc ttcacaagcc actcccttgc
     9181 ctgcaatatc gtatgccgtt ccatgagccg gagaagtacg tactaccggc aggcctgccg
     9241 tatagttcac cccgtcttcc atagccaagg ccttgaacgg agccagcccc tgatcgtgat
     9301 acatcgccag gataccgtca aaatgagtat aattgcccga acccataaag ccgtcggccg
     9361 cataaggacc gtagcaaagg attcctttct cttccatttc tttcatggca gggataatca
     9421 cttcctgctc ttccattccc aacaaaccac cgtctccggc atgaggattg agagagagca
     9481 ccgcaatacg cggagcgccg ataccgaaat cctgtttcag acaacgatgg aatatcatca
     9541 gtttctcctg aatcagttct ttggtaatcg tagtcgcgat ctctctgaca gggatatgtg
     9601 tcgtcaccaa agccacccgg aagtcattct tcatcaaaat catcaatgac ttatcaccat
     9661 tacccagacg ttcttcgata tattccgtat gtccggggaa ggagaactct tccgactgaa
     9721 tcgtatgttt gttgatcgga gctgttacga taacgtctat caacccttcg cgatattctt
     9781 cgatggcacg ttccaaagcc cccagcgcag ctttaccggc ttcgggatcg ggtttggaaa
     9841 attccacttt cacctcatca tccgtacagt tcaccacgct caaacggttg taccccgctt
     9901 cggtagcaga gttgacaata ctgaaattgg tctgtatatc cagtgctttg cgatgataag
     9961 ccgctacttt cggtgagcca taaatgatcg gagtacatag ttccaacatc gtagggtcgg
    10021 aaaatgtctt aagaatcacc tcatagccca ccccgttaat atctccttgg gtgataccta
    10081 tccttatctt gttatcttcc atgtttttat ttattagttt gttccgcttc cttagatgct
    10141 tctcccaatg gaatctgatt ctgctgaact tcattcggaa gtttcagtgt atacagagat
    10201 gcttccatct ggcgtaccag gttgcgtttc attttatcag gtgaataaac aaatatttct
    10261 gctgttataa ttcgttggtt tttctcgtcc agacgagtat gagatacata cgggccaccc
    10321 ataaagtcgc ccttcatacg ccacaggcca cgtgcttcca ttgtgtagct gttctgtaca
    10381 ttgatcggac ggacatcggt cagcaaacta tcggttgaca tataaacgcc ttccttgaat
    10441 ccggggatat tggctttcat cacggagtca cgtttgtgca caaaatattc tttggtaaac
    10501 gtatccttgt cagtgtacgg ataagagtac atcacaaagt tacggtcggc actacctgtg
    10561 ttggtagaag cccaaaagaa atcatccccg gtctttgaat tagccagttc ggcatccacc
    10621 cagatgtcgc atccgaacaa actgtccact ttctgcgaaa tgaagttact atgcttccct
    10681 tccaggaacg taatctgacg gttcatttcc gcacgggtaa agaagtcgac aatcgtcttt
    10741 ttgttctctt ccacaaactt ctcgaattct tcttcgttcg gagcctggat agtcaatatc
    10801 atctgcggat tggcatacac gtccttcgca tatttgaacg aggctttcgt atatatatcc
    10861 tgtatatcta caataataat gttacgtatc aacttcagcg tagaatcata atctttcggt
    10921 gaagtataca taatccggaa agaaggttcc gactgcggca aaccgggcat atcagcatcg
    10981 agcgcatcat gtaaagccct tccggcagca cgatcccaaa caccgtgatc tactacaacc
    11041 aaaagctcgt aagcacgacc actagaggtg tgatttcctt tcagaccaca agatgcaacg
    11101 acaaaggcta ccaaagcgat gcataaaata aaagagtact ttttcatgat gttcggtttt
    11161 atatattaac tttcattatt tttctcctgt ttcgctgtcg acagcatacc gcaagcggca
    11221 aaaatatctt cgcccctgga tgaacggata gtggtgaaaa gtccgtgtga cgtcagataa
    11281 tcacgaaaac gggtcatcgt atccatgtcc gccccctcga gatctacccc cggtatggca
    11341 tgaaaacgaa tcagattcac cctgcaatcc agcccgcgaa gaagtttcag caactctttg
    11401 gcatagacct gcgaatcatt gagcccttta aaaacaatat attcaaacga aagtcgacgt
    11461 tgtttactaa aatcatagtt ttttaacagt tccaccattt cggtgattga aaacgccttt
    11521 tccgccggca ttaattcagc acgctgaacg gtcagcggag agtgaaggct gatagcaagg
    11581 tggcagtcat tttcttcaat aaaacgctgc aatcctttcc gtagcccgac tgtagaaagc
    11641 gtgatacgct tcggactcca tgcgtaaccg taggtagcgg tcagtagttc caatgccttc
    11701 aatacctcat ccaggttatc gagcggctcg cccattccca tcattacgac attagtcagt
    11761 ttgtcccgtt ccggcagcga atgaatctgg tttatgatct ggctggcggt caggttagcc
    11821 gtatacccct gtttgccggt catacagaac ttacagttca tcttgcaacc tacttgtgac
    11881 gacacgcaca acgttgcccg gtcatcatcc ggtatataaa ccgactctac aaaatggttc
    11941 tcacccactt tataaagata cttcaccgta ccatctacag agcgcatttc atctaccgga
    12001 gcttccgctc ccacctcata gttctgcttg agcaactccc ggtgtttcaa tgacaaatta
    12061 gtcatatcat caatcgaggc taccttcttt tcgtaaagcc aggatgcaat ctgcttggca
    12121 gcaaagccgg gcatatccag tctttttgtc aatgattgaa gctctacaag agtcattcct
    12181 aaaaggggat atttagacat tcttctttct gttgatagtt tatatctgca aatgtaagga
    12241 aataaagtcg atttccgtat agcaggaatg taaaagttaa caaaaaaggg aagtatgcct
    12301 ccgttatgat tcaaccacgc tgatatattg aagtagcttt tgcgccattt cagaatcctc
    12361 gccattcttt ttcacttcat gaccgtacgc ctcacggaaa caagccagcg cctcttcccg
    12421 ttcattacaa aagctgtgca aaacccctaa gttctgacaa gccagaatcg tatcttcttc
    12481 ctcccatccc aaatacttct ttcgcagttc gaactctctg aagaaagcct ctttcgccat
    12541 tggataattc tccaacttca cataagcctg tgctttgtaa taatatacca gacaggaagc
    12601 attagggtca gcatcatcgt gaatatccaa agacgttgca atacgaatca cgttatcata
    12661 gtctttattc atgtaatact gctgcataat atcacatctc aatgcctcgt agcggacagt
    12721 cagttccgcc agacgcggtt tttcgctgaa acacatttca tgcagaagag actcacggaa
    12781 gaataaagta gacgcctgct catcgccacg ttcattcatc atccgtttga attccctgca
    12841 tagataatac aactgtttat gacaagcgac gatctgtttt ttattatcta tctgtatagc
    12901 aatgtccaac gcctgattca tcagcatcca tgcttcatcg tatcgtttga tataataaag
    12961 acatttaccc tgcatacgca aacatttagc cactccaccg gacagtctgc cattcaacga
    13021 ctcgtgcatt tcagcaactt tccggaattt ctcggcagca ctctcttcct catccttata
    13081 gtaatcacaa taagccagat attcggaaag ttcaatgact tctgcctgac tcttctcgtc
    13141 agcagaagcc gcatgataat caagcgccct attcagatag atcactgctt cattgtattg
    13201 ctcattgtag taatatgcca gagctagatt tcggcaggtg ttggcaatct ccagttccgg
    13261 agtcggtaca atgttttcct gcatcaccaa tgctttcagg aaacagtcgc atgccgtttc
    13321 gtattcttca ttacgggcat atcggcatcc ctcattcatc ttcaataccg acttggcaat
    13381 gagtggcata gcagcacctt ccatactctt ctcactcaca gcagctgccg ccttcgtcag
    13441 atggaaagaa ctgctcaaga aagtagccat atcattagca ataacaggaa ttaaaaaaga
    13501 atcgatctca tcaaagtcca attcggcata gacttcaggc gtaacttcag gattgtcgtt
    13561 catgatcgct ttccagctat cttccaacaa agaacgattc gtgcgataca gaatctcgaa
    13621 aatctccaca tcacaaatcc aatccttcaa tatatcccat tcttgcatct tatagcattg
    13681 ataggtaatc tccactttat agcgatacga atcatggtag cagaactgtt tcatgcgata
    13741 gttataatcg gcaaaagtca acggatggga aaggatttct tcctcatcca gcagagcgga
    13801 aataatttca tggcgactat catctataca ttcgtcatct tgagcgaaat agcgttcgat
    13861 cgcctctacc atttgtgtgt caccaatgca atatcgtcct cctttgttgg tgagccagct
    13921 gctcatttcc actctcaact gcgaccaaag tatctgatta atgtctgcca tgctcttcac
    13981 ttcatcttcg gtaaatcctt ctaaagtaag tgaaagcatc agaagcgttc ttc
//
