LOCUS       c00093_gnlPro..        10398 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BODIBGDG_93.
ACCESSION   c00093_gnlPro..
VERSION     c00093_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 19:42:15
            Original ID  :: gnl|Prokka|BODIBGDG_93
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10398
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10398
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[406:5729]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      407..5729
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..10398
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10398
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             407..1843
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg93_1"
                     /sec_met_domain="CT_Vparvula (E-value: 9.6e-137, bitscore:
                     445.7, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNATQSLAGTRITSLLDANSFVEIGQGVTARSTDFNMTANKAPS
                     DGVITGYGVIDDKLVYVYSQDASVLNGTVGEMHAKKITRLYDLAMKTGAPVIGLVDCAG
                     IRLQEATDALEAFGQIYLKQTLASGVIPQITAIFGTCGGGMAVIPSLTDFTFMESKKGK
                     MFVNTPNALEGNNTDKCDTAAADFQSKETGVIDGVGTEDEILGQIRSLVSLLPSNNEDT
                     DNYTECTDDLNRVCADLANCAGDTAIALSQIADNGEFFETKADYAKDMVTGFIRLNGAT
                     VGAVANRSEVYDAEGKKTETFDGSISARGARKAADFVKFCDAFDIPVLTLTNATGFMAT
                     LCSEKMMAKSVGELVAAFADATVPKVNVIIGKAYGTAYVAMNSKSIGADLVYAWDNAEI
                     GMMDASLAAKIMYADADAAELNEKAAQYRELQNGVASAAARGYVDTVISPADTRKYVIG
                     AFEMLFTKREDRPSKKHGTV"
     CDS             1858..2613
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg93_2"
                     /sec_met_domain="OAD_gamma (E-value: 6.3e-28, bitscore:
                     86.6, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKMIKKITSVFMTFLVMAALVIGSTSVVFAADKVDDTVKSTLVTT
                     AEGLTDAIVQLKDEEIENYMSSGDDFTTSAMQSWQTSKDELGAKKDSNGETTVTFKDDQ
                     YTVTVPLKFEKAEANFVYVFDSQGTPTSMSVDVQYGMGKTLQRAGLNTLMGIGTVFVML
                     ILLSLLISLFRFIPNPEAKKAAEAKAAKAAKEAEAAAIAQTAPAQAEENLADDGELVAV
                     IAAAIAAAEGTTTDGFVVRSIRKVKRNRR"
     CDS             2641..3009
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63; E-value:
                     6e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg93_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 8.8e-21, bitscore:
                     63.0, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGTAYEVTVEETGSVSAPAAAPKAAPKAAPAAAPKAA
                     APAAGAGAVKVTASVPGKVVKVAASVGQAVKAGDSVVILESMKMEIPVVAPQDGTIASI
                     DVAEGASVENGDTLATMN"
     CDS             3026..4174
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg93_4"
                     /sec_met_domain="OAD_beta (E-value: 3.8e-157, bitscore:
                     511.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVTETLSNLIHQTAFFNLTWGNYLMIAVACVFLYLAIKKGFEP
                     LLLVPIAFGMLLVNIYPDIMANPEDMSNGVGGLLHYFYILDEWSILPSLIFMGVGAMTD
                     FGPLIANPISFLMGAAAQLGIYAAYFLAIFLGFNGKAAAAISIIGGADGPTSIFLAGKL
                     GQSALMGPIAVAAYSYMSLVPIIQPPIMKLCTTEKERKIKMDQLRPVSKLEKILFPIVI
                     TIVVCLILPTTAPLVGMLMLGNLFRECGVVKQLTETASNALMYIVVILLGTSVGASTSA
                     EAFLNADTLKIVVLGLVAFAIGTFGGCMLGKLLCKLTHGKINPLIGSAGVSAVPMAARV
                     SQKVGAEADPTNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             4317..5729
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg93_5"
                     /sec_met_domain="HMGL-like (E-value: 3.2e-47, bitscore:
                     150.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 3.6e-59, bitscore:
                     189.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELEKKPVKIVETILRDAHQSQIATRMTTEQMLPIVDKLDKVGY
                     HAVECWGGATFDASLRFLHEDPWERLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSAANGIDIIRIFDCLNDLRNLQTAVSAANKEKAHAQVALSYTLGDAYTLEYWTD
                     IAKRIEDMGADSICIKDMAGLLLPNKATELVTALKETVKIPIDLHTHYTSGVASMTYLK
                     AVEAGVDIIDTAMSPFALGTSQPATEVMVETFKDTPYDTGFDQKLLSEIADYFRPIRDE
                     ALDSGLLNPKNLGVNIKTLLYQVPGGMLSNLTSQLKEQHAEDKFYDVLEEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKMVTKETKDILLGKYGATVKPFNPEVQKKCIGD
                     EKPITCRPADLLDNELEKLESEMAQYKEQDEDVLTYALFPQVAMDFFKYRQAQKTKVDE
                     KAADKKNGAYPV"
     CDS             5841..7301
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg93_6"
                     /sec_met_domain="HI0933_like (E-value: 3.1e-128, bitscore:
                     417.1, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPVVHIYIDLSEAETWNYDEIDNLQGKINTGEYSMSKVIIIGGG
                     AAGMMAGVFAARNHHEVHILEKNEKLGKKVFITGKGRCNVTNACDTEELFPAMMSNPKF
                     LYSSFYSFTPQDVMEFFEKAGVPLKVERGNRVFPQSDHSSDIIRALERELKKAGAKIHL
                     HTAVQEIVKKPVTESVTDSVNTLESEAALTESGFDAGKSRKGKKSPDIPQEKITGVILT
                     DGTFMEGDAVIVATGGFSYQSTGSTGDGYRFARELGLKVTDIAPSLVPLKTKEDYVPKL
                     QGLSLKNTGLTIKNGKKVLYEDFGEMMFTHFGVTGPMILSASAHIGAKLAKAPNGELSA
                     YLDLKPALTREQLDARILREFEAGPNKQFKNVIGVLFPSSLTPVMLELGGIPAEKKIHD
                     ISREERQHFIDLIKAFPFTITGMGEFKEAIITRGGVSVKEINPGTMESKKISGLYFAGE
                     VLDLDAVTGGYNLQIAWSTAYLAAQAIQ"
     CDS             7487..8158
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytidylate_kin"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg93_7"
                     /sec_met_domain="Cytidylate_kin (E-value: 4.7e-78,
                     bitscore: 251.0, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGCNIAIDGPAGAGKSTIAKKVAKELSFIYVDTGAMYRAMALYLL
                     NHGVNGENQEEIEAVCSGADISIEYKNGEQIVILNGENVNAMIRTEQVGNMASKSSANP
                     KVRAHLLKLQRTLAEKNDVVMDGRDIGTTILPNAEVKIYLTASADTRAKRRALEYEQKG
                     EPFDLDQIRKDIIERDERDMNREISPLKQAEDAVLVDSSEMGIDDVVNAILNVYKEKVQ
                     K"
     CDS             8177..9055
                     /locus_tag="ctg93_8"
                     /transl_table=11
                     /translation="MKVKVAETAGFCFGVKRAVNKVYELIDTEQKPIFTLGPIIHNEGV
                     VADLEARGVHVITEADLDFPDDTLQNGTVVIRSHGVGKAIYDKLKEKNISYVDVTCPFV
                     LKIHRIVEKESLAGNHIIIIGDKDHPEVQGICGWCQGPYTVIRNKEEAEVFVPPKGKKI
                     SIVSQTTFNYNKFKDLVEILCKKRYDNNVLNILNILNTICNATEERQREAKNIAGEVDT
                     MLVVGGRHSSNTQKLFEICKKECGNTYYIQTPVDLDSEMFQCSSYVGITAGASTPNKII
                     EEVQEHVRIKF"
     CDS             9036..10112
                     /locus_tag="ctg93_9"
                     /transl_table=11
                     /translation="MSELSFEQMLEDSVKTIRNGEIVQGTVIDVKEDEIILNIGYKADG
                     IITKNEYSNDASLVLTDAVHVGDTMEAKVLKVNDGEGQVTLTYKRLAAEKGNKRLEEAF
                     ENQEVLKAPVTQVLDGGLCVNVDEARVFIPASLVSDTYEKDLSKYADQEIEFVITEFNP
                     RRRRIIGNRKQLLLAEKAEKQKELMERIHVGDTVEGTVKNVTDFGAFIDLGGADGLLHI
                     SEMSWGRVENPKKVFTVGDKVKVLIKEINGEKIALSLKFPEANPWLTAAEDFAVGNVVK
                     GKVARMTDFGAFVELAPGVDALLHVSQISREHVAKPSDVLSIGQEIEAKVVDFNGEDKK
                     ISLSMKALEAPAEEATEE"
ORIGIN
        1 gctgagactt ttatacctgt gcagtcggat tcgcagacaa gtgagtggta tagttacctc
       61 aaacacgctc tggtgtgccg acaagttgat tcttgaaaca gtcttgcagg atagaaataa
      121 gaaattcaga cgcaggattg ttcgagaaat caacttgtcg atacactggt ttgcgggaga
      181 gggtgaaata cgggacaata caaaataacc gtaataccct ctattaaata ggaagaaatg
      241 ctcaaaaaaa caaaatttgg agaaacctga caaatttttc tgctatattt ttaacgaaaa
      301 tgacaaataa atgttgaaat tttctgccgg aaaaggtaaa attaaaatcg gctaaatttt
      361 tgggttaact tttaaatatt ctcataaaga tggagggcaa acaagaatga gtaatgcaac
      421 acaaagctta gcaggcacaa gaattacttc tttgcttgac gcaaacagtt ttgtcgaaat
      481 cggacagggt gtaacagcca gatccacaga tttcaacatg actgcaaaca aggcaccatc
      541 tgacggtgtt atcaccggat atggtgtgat cgatgacaaa ctggtttatg tatacagcca
      601 ggatgcatct gtattaaacg gtactgttgg tgaaatgcat gcaaagaaga tcacaagact
      661 ttatgatctt gccatgaaaa caggcgctcc ggttatcgga cttgttgact gtgcaggtat
      721 ccgtcttcag gaagcaacag acgcactgga agctttcgga cagatctatc tgaaacagac
      781 actggcatcc ggtgtgatcc cgcagatcac agcaatcttc ggaacatgtg gcggtggtat
      841 ggcagttatc ccgtccctga cagatttcac attcatggaa tccaaaaaag gaaaaatgtt
      901 cgtcaacaca ccaaacgcac tggaaggaaa caacacagac aaatgcgaca cagcagcagc
      961 tgatttccag agcaaagaga caggtgtgat tgatggcgtt ggtacagagg atgagattct
     1021 tggccagatc cgttccttag tatcacttct tccttctaat aatgaagaca cagacaatta
     1081 cacagagtgt acagatgatc ttaaccgcgt atgcgcagat cttgcaaact gtgcaggtga
     1141 cacagcaatc gcactttccc agatcgctga caacggtgaa ttcttcgaga caaaagcaga
     1201 ctatgcaaaa gacatggtta caggctttat ccgtttaaac ggcgctacag taggtgctgt
     1261 tgcaaacaga agcgaagtat atgacgcaga aggcaagaaa acagaaacat ttgacggaag
     1321 catctctgca agaggcgcaa gaaaagcagc agatttcgtg aaattctgcg acgcttttga
     1381 tattccggta cttacactta caaacgcaac aggcttcatg gcaaccttat gcagcgagaa
     1441 gatgatggcg aaatccgtag gtgaactggt agctgcattc gcagatgcaa ctgttccgaa
     1501 ggtaaatgtg atcatcggca aagcttacgg tacagcttac gtggcaatga acagcaaatc
     1561 tattggtgca gaccttgtat atgcatggga taacgcagag attggtatga tggatgcttc
     1621 cctggcagcc aagatcatgt atgcagatgc agatgctgct gaactgaatg aaaaagctgc
     1681 tcagtacaga gagcttcaga atggtgttgc ttccgcagca gcaagaggct atgttgacac
     1741 tgtgatcagc ccggctgaca caagaaaata tgtaatcggt gcatttgaga tgctgttcac
     1801 aaagagagaa gatcgtccgt ctaagaaaca tggaacggtc taagcggggt gacgcatatg
     1861 aaaatgatca aaaaaataac ttctgtattc atgacatttc tcgtaatggc tgcgctggtg
     1921 attggcagca cctctgtggt atttgccgca gataaggttg atgatactgt taagtccaca
     1981 ctggtaacta cagcagaagg actgacagat gccattgtcc agcttaaaga tgaagaaatc
     2041 gagaattaca tgagttcagg agatgacttt acaacaagtg ccatgcagtc ctggcagaca
     2101 tccaaggatg aacttggcgc aaagaaggac agcaatggtg aaactactgt aactttcaaa
     2161 gatgatcagt acacagttac tgttcctctt aaatttgaga aagcagaagc aaactttgta
     2221 tatgtctttg actcacaggg aacaccgact tccatgtctg tagatgtaca gtatggtatg
     2281 ggcaagactc ttcagagagc aggtcttaat actctgatgg gtattggaac tgtattcgta
     2341 atgctgattt tattaagcct tctgatttct ctgtttagat ttattccgaa tccggaagca
     2401 aagaaagcag cagaagcaaa agcagccaaa gctgcaaaag aggcagaggc agcagccatc
     2461 gcacagacag cacctgcaca ggcagaagag aaccttgcag atgacggaga gctggtagct
     2521 gttatcgcag cagctatcgc agcagcagaa ggaactacaa cagatggctt cgtagttcgt
     2581 tccatccgta aagtaaaaag aaatagaaga taattgtcat ttatttagga ggattttaaa
     2641 atgaaaagct atacaattac agtaaatggt acagcatatg aagtaactgt tgaagaaaca
     2701 ggaagcgtat ccgctcctgc agcagctcca aaagcagcac ctaaggctgc acctgcagca
     2761 gctccgaaag cagcagctcc tgcagcaggc gccggcgcag tgaaagtaac tgcttccgta
     2821 cctggtaaag ttgtcaaagt agcagcaagc gttggacagg cagtaaaagc cggagacagc
     2881 gtagttattc ttgaatccat gaaaatggaa atccctgtag tagctcctca ggacggtact
     2941 atcgcaagca ttgatgttgc agaaggtgcc tctgtagaaa acggagatac tttagcaaca
     3001 atgaactaag acgggaggta gtcaaatgtc ttatgtaaca gaaacattgt ccaacctgat
     3061 tcaccagaca gcattcttca atctgacatg gggcaattac ctgatgatcg cagtagcctg
     3121 cgtattcctt tatcttgcta tcaagaaagg attcgagccg cttctgcttg ttcctatcgc
     3181 attcggtatg ctgcttgtaa atatctatcc ggacattatg gcaaatccgg aagatatgtc
     3241 taacggtgta ggcggacttc ttcattattt ctacatcctt gatgagtgga gtatcttacc
     3301 atccctgatc ttcatgggtg taggtgccat gacagacttc ggcccgctga ttgccaaccc
     3361 gatcagtttc ctgatgggtg cagcagcaca gcttggtatc tatgcagctt acttccttgc
     3421 aatctttctt ggattcaacg gaaaagcagc agcagctatc tccatcattg gtggtgctga
     3481 cggcccgact tccattttcc ttgcaggtaa acttggacag tctgcactga tgggaccgat
     3541 cgcagtggca gcatattcct atatgtcact ggttccgatc atccagccgc ctatcatgaa
     3601 actctgcaca acagagaaag aacgtaagat caaaatggat cagcttcgcc cggtttccaa
     3661 actggagaag atcctgttcc caatcgttat cacaatcgtt gtctgcctga tcctgcctac
     3721 aacagctccg ctggttggta tgctcatgct tggtaacctg ttcagagagt gcggtgttgt
     3781 aaaacagctg acagaaacag catccaatgc cctgatgtat atcgtagtta tccttctggg
     3841 tacatccgta ggtgcttcca caagtgcgga agcattctta aacgcagata ctctgaagat
     3901 cgtagtttta ggtcttgttg cattcgcaat cggtacattc ggtggatgta tgcttggtaa
     3961 actgctctgc aaactgactc atggaaagat caacccgctg atcggttccg caggtgtatc
     4021 cgcagtacct atggcagccc gtgtatccca gaaagtgggt gcagaggcag atcctacaaa
     4081 cttccttctg atgcacgcaa tgggcccgaa cgttgccggt gttatcggta cagccgtagc
     4141 agccggaaca ttcatggcta ttttcggagt ataaccaaat caagcaagct atcttgcttg
     4201 tatcaggagg agtgcaactc cttctgataa gctgcggagc agctatttgg ttatgagcaa
     4261 gtagcgaagc ggattgcgaa tatccgatta aacagaacta taaaggagat ttaataatgg
     4321 cagaattaga gaaaaaacct gttaaaattg tggaaaccat tctccgtgat gctcatcagt
     4381 cccagatcgc aacacgtatg accacagaac agatgcttcc gatcgtagat aaacttgaca
     4441 aagtcggcta tcacgcagta gagtgctggg gtggtgcaac attcgatgca tcccttcgtt
     4501 tccttcacga agatccatgg gaaagacttc gtaaattacg tgacggcttc aagaacacaa
     4561 aacttcagat gcttttccgt ggacagaata tccttggata ccgtccatac gcagatgacg
     4621 ttgtagaata cttcgtacag aaatcagctg caaacggaat cgacatcatc cgtatttttg
     4681 actgcctcaa tgaccttcgt aacctgcaga cagcagtaag cgctgcaaac aaagagaagg
     4741 ctcatgcaca ggtagctctt tcctatacat taggagatgc ttacacactg gaatactgga
     4801 cagacattgc aaaacgtatt gaagatatgg gcgctgattc catctgtatc aaagatatgg
     4861 caggtcttct ccttccaaac aaagctacag agcttgttac agcattaaaa gaaacagtta
     4921 agatcccgat cgaccttcat acacattaca cctccggtgt agcttccatg acttacttaa
     4981 aagcagtaga agcaggtgtg gatatcattg atacagcaat gtctccattt gcactgggaa
     5041 catcccagcc tgcaacagag gttatggttg agacattcaa ggatacacca tacgacacag
     5101 gatttgatca gaagcttctt tccgagatcg ctgactactt ccgtccgatc cgtgacgaag
     5161 ctcttgacag cggactgctc aatccgaaga accttggtgt taacatcaag actttactgt
     5221 atcaggtacc gggcggtatg ctctccaacc tgacttccca gttaaaagaa cagcacgcag
     5281 aagacaaatt ctacgatgtt ctcgaggaag ttccgcgtgt acgtaaagac cttggtgaac
     5341 cgccacttgt tactccgtct tcacagatcg ttggtacaca ggctgtattc aacgtactca
     5401 tgggcgagag atacaaaatg gttacaaaag aaacaaaaga tatcctgtta ggaaaatacg
     5461 gcgcaactgt aaaaccgttt aatccggaag tacagaagaa gtgcatcggc gatgagaaac
     5521 cgatcacatg ccgtccggca gaccttcttg acaacgagct tgagaaactt gagagcgaaa
     5581 tggctcagta caaggaacag gatgaagacg tattaacata cgcactgttc ccacaggtag
     5641 ctatggactt cttcaaatac cgtcaggctc agaaaacaaa agttgacgag aaagcagctg
     5701 ataaaaagaa cggagcatat cctgtataat tgatcagtaa ttaaatatgt ccaaacgaaa
     5761 aaaggagctt gcgtaagcag gctcctttgc gttattatga aagaatatga tacccgggaa
     5821 tataatgtgc caatgggtat atgctgccag tggtacatat ctatattgat cttagtgaag
     5881 cggaaacgtg gaactatgat gaaatagaca atctgcaggg taaaataaat acaggagaat
     5941 attccatgag caaagttata ataatcggcg gcggagccgc cggaatgatg gcaggggttt
     6001 ttgcagcccg taatcatcat gaagttcata tattagagaa gaacgagaaa ctgggaaaga
     6061 aagtcttcat cacaggaaaa ggcagatgca atgtgacaaa tgcctgcgac acagaagaac
     6121 tctttcctgc aatgatgagc aatcccaagt tcctctacag cagtttctat tcatttaccc
     6181 ctcaggatgt aatggagttc tttgagaaag caggtgtccc tctgaaggta gagcgtggaa
     6241 acagagtatt cccacagtct gaccattctt cagacatcat ccgcgctctg gagcgtgagc
     6301 tgaagaaagc aggagcaaag attcatcttc acactgctgt gcaggaaatc gtaaagaaac
     6361 ctgtaacgga atctgtaaca gattccgtaa atacccttga atcagaagcc gcattaacag
     6421 aatcaggatt tgatgcagga aaaagcagaa aaggaaaaaa atcacctgac ataccgcagg
     6481 agaagatcac aggagtcatc cttacagatg gaaccttcat ggaaggagat gcagtcatcg
     6541 tggcaaccgg tggattctct tatcagagta caggctccac aggtgacgga taccgcttcg
     6601 caagagaact gggactgaaa gtcacggaca ttgctccctc ccttgtgcca ttaaagacaa
     6661 aagaagacta tgtccctaag cttcagggac tttcccttaa gaacacagga ctcaccataa
     6721 agaatggaaa gaaagtactc tatgaggatt tcggagagat gatgttcacc catttcggag
     6781 tcacaggccc catgatcctc tccgccagtg cccacatcgg tgcaaaactg gcaaaagcac
     6841 caaacggcga actgtccgca tatctggatc tgaagcctgc actcaccaga gaacaactgg
     6901 atgccaggat cctgcgtgaa tttgaagcag gaccaaacaa acagttcaag aatgtgattg
     6961 gcgtactttt cccgtcatct ctgacgccgg taatgctgga actgggtgga atccccgcag
     7021 agaagaaaat ccacgatatc tccagagaag aacgccagca cttcattgac cttatcaaag
     7081 ccttcccctt cacaatcaca ggaatgggtg agtttaaaga agccatcatc accagaggcg
     7141 gcgtctctgt caaagagatc aatcccggaa cgatggaatc aaagaaaatc tcaggtcttt
     7201 acttcgcagg cgaggtactg gatctggatg cagtgacagg tggatataac ttacagattg
     7261 cctggtctac cgcatatctg gcagcacagg ccatacagta agctgcttac tatagaaaca
     7321 acagaaacaa gcagatgatg agtaccgtgt atgcgaatta tatctatgat tcggttatga
     7381 gcaagtagcg aagtggattg cgaatatccg cttgactgat taataaacat taataataaa
     7441 acagagaaaa tctgtttgaa taatagaaac aggaggaacc acgaaaatgg gatgtaacat
     7501 agccatcgac ggacctgcag gagcaggaaa gagcaccatc gcaaagaaag tagcgaaaga
     7561 attatcattt atctatgtag atacaggagc catgtacagg gcaatggctt tatatcttct
     7621 gaaccatggc gtaaacggag aaaatcagga agagatcgaa gccgtatgtt ccggcgctga
     7681 catttccatc gaatacaaaa acggagaaca gattgtcatc ctcaacggag agaacgtaaa
     7741 tgctatgatc cgcaccgaac aagtaggaaa catggcatcc aaaagttccg caaacccgaa
     7801 agtcagagct catcttctga aacttcagag aactctggca gagaaaaacg acgtagtcat
     7861 ggacggcaga gatatcggca caaccattct tccaaacgca gaagtaaaaa tctacctcac
     7921 agcaagcgca gacaccagag caaaaagaag agcactggaa tatgagcaga agggagaacc
     7981 cttcgacctg gaccagatcc gaaaagacat catcgagcgc gacgaacgcg acatgaaccg
     8041 cgaaatctcc cctctgaaac aggcagagga cgcagtgctt gtagattctt cggaaatggg
     8101 aattgatgat gttgtaaatg cgattcttaa tgtatataag gaaaaagtgc agaaataatt
     8161 taagaaggat tattttatga aagtaaaagt agcagaaaca gcaggcttct gctttggcgt
     8221 caaacgtgca gtgaacaaag tctacgaact catagacaca gaacagaaac ctattttcac
     8281 tctgggcccg atcatccaca acgaaggcgt agtagcggat ctggaagctc gtggcgtcca
     8341 cgttatcaca gaagcagacc tggatttccc ggatgatacc ctgcagaacg gaacagtagt
     8401 catccgctct cacggtgtag gcaaagccat ctacgataag ctgaaagaaa aaaacatctc
     8461 ttatgtagat gtgacctgcc ccttcgttct gaaaatccac aggatcgtgg aaaaagaaag
     8521 ccttgcagga aaccacatca tcatcatcgg cgacaaagac caccccgaag tacagggcat
     8581 ctgtggctgg tgtcagggac cgtacacggt gatcagaaac aaagaagaag ccgaagtatt
     8641 tgtaccccca aaaggcaaaa aaataagcat tgtgtcccag acgacattta attacaacaa
     8701 atttaaagat ttagttgaaa ttctttgcaa aaagaggtat gataataatg ttttaaatat
     8761 tctcaatatt ttaaacacta tttgtaatgc taccgaagaa cggcagagag aagcaaaaaa
     8821 catagccgga gaggtagaca ctatgttggt cgtaggcggc cggcatagtt ccaatactca
     8881 aaagctgttt gaaatatgta aaaaggaatg tggaaatact tactatatac aaacacctgt
     8941 agacttggat tctgaaatgt tccaatgcag tagttatgta ggtattacag caggggcttc
     9001 caccccaaac aaaattattg aggaggttca agaacatgtc agaattaagt tttgaacaaa
     9061 tgctggaaga ttccgtaaag actatcagaa atggagagat tgtacagggt actgtcatcg
     9121 atgttaaaga agatgagatt attctgaata tcggttataa agcagacggt attatcacaa
     9181 agaacgaata ctctaacgat gcaagccttg tactcacaga tgctgttcac gttggagaca
     9241 caatggaagc aaaagttctc aaagtaaacg atggagaagg tcaggttact cttacttaca
     9301 agagactggc agcagagaaa ggcaacaaac gtcttgaaga agcatttgag aatcaggaag
     9361 tattaaaagc tcctgtaact caggtacttg acggcggact ttgtgtaaac gtagacgaag
     9421 caagagtatt cattcctgca agcctcgttt ccgacacata cgagaaagac ctttccaaat
     9481 atgcagatca ggagatcgaa ttcgttatca cagaattcaa cccgagaaga cgccgcatca
     9541 tcggtaaccg taagcagctt cttcttgctg agaaagcaga gaaacagaaa gaattaatgg
     9601 agagaatcca tgttggtgac acagttgaag gaacagttaa gaacgttaca gatttcggtg
     9661 cattcatcga tctgggcgga gctgacggac ttcttcacat ctccgaaatg tcctggggca
     9721 gagtagagaa cccgaagaaa gtattcactg ttggcgataa agtcaaagtt cttatcaaag
     9781 agatcaacgg agagaagatc gcactttccc ttaaattccc ggaagcaaat ccatggctca
     9841 cagcagctga ggacttcgct gtaggaaacg tagttaaagg taaagttgca cgtatgacag
     9901 acttcggcgc attcgtagag cttgcacctg gagtagatgc actccttcac gtatcccaga
     9961 tttccagaga gcacgttgcc aaaccttcag acgtactttc catcggacag gagattgaag
    10021 ctaaggttgt tgacttcaac ggcgaagata agaagatcag cctgagcatg aaagctcttg
    10081 aggcaccggc tgaggaagct acagaagaat aattaagaga atactcataa atattcagca
    10141 accggctttg tatgaggatg atcatacaga gccggttgat tgttttttta gattacgaat
    10201 gtggtcagca gttacaggag catcagaaat gctgcagaca gtcaggaagg ttattaacag
    10261 ttaaatataa attataaaat catataagta catgttgagt gttataagat attagagtag
    10321 aatattattg aaaggagttg attctttgag taaatattat tctatacatg aattttcaaa
    10381 aattataggc gtatctgc
//
