LOCUS       c00148_gnlPro..        12345 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ELOGBILD_148.
ACCESSION   c00148_gnlPro..
VERSION     c00148_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 19:08:24
            Original ID  :: gnl|Prokka|ELOGBILD_148
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12345
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12345
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4271:8833]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4272..8833
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..12345
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12345
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(2..2851)
                     /locus_tag="ctg148_1"
                     /transl_table=11
                     /translation="MRENAFVEAWKTQHRRVSMILGLTLLCAPSAISVYAENGVNDITV
                     QAVMQTKTVKGTVLDENGEPLIGVSIVVKGTSTGTITDFDGKFSINLPAGSKELVVSYI
                     GYKEQAIIVSGNAPLNIKMVPDTQALDEVVVIGYGTVKKRDLTGAVASVKSEDITMNPG
                     VNPMDALQGKIAGLDITNSSGQAGSSPTVQLRGTRSLQLDEDGNISSDAFKPTYIIDGM
                     PGDIATLNPNDIESIEVLKDASSTAIYGSSGANGVIIVTTKGSKSGKPVINFNAYAGTT
                     LGAKVPKMRTGDSYINYIKDSYKPVGTTNEEEIFGERYDAIKNNQWVNWGDEVLHSGLK
                     QNYSISVAGGTEKTKAYFSLNYTDEKSMYENDDYKVYSTRVRIDQEINKWINAGINVQA
                     SFSNKNSRNAVLERALFATPLGTPYNEDGSITEFPIPGSSSDPNPLADEQDGVYKNNTK
                     AGRAYVDAYLAWKPVKGLSVKSQLGGSYSQSRAGKFMGEGSYNVLKGSTVAYGEATNKT
                     GYNYKWENIVTYHNTFNKDHDLTVTGVTSWNYNQSEEYYVYGENPATNDMLWYALQNAD
                     NKKLNSKYLMSKGMGFIGRVNYSYKGKYLFSASSRYEADSRLSKDNRWNLFPAVSVGWR
                     ISDEAFMAGTKSWLDNLKLRVGYGVAGTTAGIAEYSSMASLENVTTSLGGMTVPSAKFT
                     EYITNRNLTWEKTHDLNIGIDASFLNNRIDLTVDLYRTKTTDVILSQALPTSIMGNYTG
                     STTYKMNKNAAETENRGIELALNTRNIVKKDFTWSSTVTFTANKEKIKSLIEGQDMMFN
                     AKKGDMVFKVGEGVGSFYRYKVLGIWQYSEKETAALFGCEPGDIKLDLPSVKKDGNGYY
                     YMNPEGERVDITAENPYGVRADYDRQVIGRNTPDWTLGFKNNFRYKDFDLSVFLYARWG
                     QMMNYGSVIGKYSPNPDYLP"
     CDS             3100..4098
                     /locus_tag="ctg148_2"
                     /transl_table=11
                     /translation="MPLKLTTYYRGKDIPDLPGTNTFHSKELFQIYESTPGYTPLLIVA
                     TEEGRPVARLLAAIRKTKKWLPSSLVKQCVVYGAGEFLDTSLPASKEKEEEIFGEMLEH
                     LAQEASRTCILIEFRNLDNSMFGYRFFRKNDFFPVNWLRVRNSLHSTQKAEDRFSPSRI
                     RQIRKGLKNGAKVVEAHTVEEIKEFSRMLHKVYSSRIRRYFPANDFFRHMNSMLIRGKQ
                     AKIFIVKYKEKIIGGSVCIYSGENAFIWFSGGMRKTYALQSPGILAVWKALEDAHERGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRISWPWLNNLLVKFYV"
     CDS             4272..4676
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg148_3"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.1e-24, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             4707..6260
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg148_4"
                     /sec_met_domain="CT_Btheta (E-value: 3.3e-291, bitscore:
                     955.2, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYLFAQDFTVTAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGLALIRTLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPN
                     KPYDMYEVISAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKFLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             6292..7212
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg148_5"
                     /sec_met_domain="OAD_gamma (E-value: 2.8e-15, bitscore:
                     46.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLLLNEVLIDNQNNFQD
                     DYGLHSAWIEIFNKSYGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGRKLLDQVVIPAGTLGPNQSYARISDGAADW
                     EVKGGSKDKYVTPSTNNKTLDSNAKMEKFEEHDSVGIGMSISAMSVVFCGLILLFIAFK
                     VVGKVAVNLSKRNAMKAKGIDKVEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRENPNRK"
     CDS             7237..7671
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.7; E-value:
                     4e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg148_6"
                     /sec_met_domain="Biotin_lipoyl (E-value: 6.5e-22, bitscore:
                     66.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKTA
                     PKPVVVRPMPNSPAAPTTPVVKPAAPSTGKSGVKSPLPGVILDIKVNVGDTVKRGQTII
                     ILEAMKMENNINADKDGKVTAINVNKGDSVLEGNDLVIIE"
     CDS             7673..8833
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg148_7"
                     /sec_met_domain="OAD_beta (E-value: 1.1e-153, bitscore:
                     500.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFISFLGNNLADFWTYTGFANATGGHIAMIIIGLGFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             9047..10381
                     /locus_tag="ctg148_8"
                     /transl_table=11
                     /translation="MKRIILLAFLCTTTLVMAQRINHVQEAIANYDYEAALTLIAKEKP
                     TIPLLLQKGKAQRGLGMNTEALSTYQEIITNDTANTRAYIEAAECCRSLAKYQQALKYY
                     EQALDLNPENKYVRIQYIGLLLSLQKFQDALGESSLMTEKDSSAIALHLQAQSFEGMGE
                     LLPATGCYYNIQEKYPDDYLAAAKLAALNIAGSYFNEAIEATEKYRQIDTTNIAVNRQN
                     ALAYCLNKDYPTAIQRYEYLVSQGDSSFHTCYYLGISYYAEEKYYEAHDFLEAARKHDP
                     ENVNLLYYLGRACAKTSWKKLGVEYLEKALDLTIPKDSNMVRLYIGMTDCYKMAQMPKE
                     QIESIRERYRKYDKQNHKLLYDMAFIYFYSLKDKKNTERCLEAFLKTRPKEDKEEEAKL
                     NERGELVLGTKNYYNAAANWLKDIQSKQKIEDFFLGGNVPAQKPE"
     CDS             complement(10461..11465)
                     /locus_tag="ctg148_9"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTRDMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCAHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTDPEEVIDFATRTGCDSLAISIGTSHGAYKFTPEQCHIDPATGRMVPPPLAFEVLDAV
                     MEKLPGFPIVLHGSSSVPEEEVETINKFGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKTFAEKPAEFDPRKYLGPARDNMEKLYKHKILNVLGSDNKLAE"
     CDS             11866..12120
                     /locus_tag="ctg148_10"
                     /transl_table=11
                     /translation="MKKGLHPESYRPVVFKDMSNGDMFLSKSTVATKETIEFEGETYPL
                     LKIEISNTSHPFYTGKSTLVDTAGRVDKFMSRYGDRKKK"
ORIGIN
        1 gaggtagata atccggatta ggcgaatatt tacctatcac actgccatag ttcatcattt
       61 gcccccaacg tgcataaagg aagacagaca aatcaaaatc tttgtatctg aaattattct
      121 taaagcccaa tgtccagtcc ggagtattac gacctattac ctgacgatca taatccgcac
      181 gtacaccata aggattttct gccgtaatat caacgcgctc tccttcagga ttcatataat
      241 aataaccatt tccgtccttc ttcacactag gtaaatccag cttaatatcg cccggttcgc
      301 atccgaacaa agcagcagtt tccttttcgc tatattgcca gatacccaac actttatatc
      361 tatagaaaga accgactcct tcgccgactt tgaacaccat atcacccttt tttgcattga
      421 acatcatatc ctgcccttcg atcaaagatt taattttttc tttgttggcg gtaaatgtca
      481 ctgttgagct ccaagtaaaa tctttcttca caatattacg ggtattaaga gcaagttcaa
      541 taccgcgatt ttctgtttca gcagcattct tgttcatttt ataagtagtg ctacctgtgt
      601 aattacccat aatagatgtc ggcaatgcct gcgaaagaat tacatccgtt gtttttgtcc
      661 gatacaaatc caccgtcaga tcaatacgat tattgaggaa gctggcgtca ataccaatat
      721 tcaagtcatg agtcttttcc catgtcagat tacggttagt gatatactcc gtaaacttgg
      781 ctgacggaac agtcattcct cccaaagaag ttgtcacatt ttccaaagat gccatagaac
      841 tgtattcagc aataccggca gtagttccgg caacaccata gcctacacgc agtttcaagt
      901 tatccaacca gctttttgta ccagccataa atgcttcatc cgagattctc cagcctacag
      961 aaactgccgg gaataaattc catctattgt ctttcgacaa acgggaatcc gcttcataac
     1021 gactggaagc agagaacagg tatttacctt tgtatgagta gttgacacga ccgataaagc
     1081 ccatcccttt cgacatcaga tatttgctgt tcagtttctt attatcagca ttctgcaatg
     1141 cataccacaa catatcattg gtcgccgggt tttcaccata gacataatat tcttcactct
     1201 gattgtaatt ccaggaagta acccctgtaa ccgtcaggtc atgatcctta ttaaatgtat
     1261 tgtgataagt tactatgttt tcccatttgt aattatatcc cgtcttattg gtagcttcgc
     1321 catatgccac cgtactgcct ttcaacacat tataagagcc ttctcccata aatttaccgg
     1381 cacgagattg agaataactg cctccaagct gtgacttgac agacaatcct tttaccggtt
     1441 tccatgccag ataagcgtca acataagccc ttcctgcttt agtattattc ttatatactc
     1501 catcctgttc gtctgctaac ggattcgggt ctgatgatga acctggaatc gggaattccg
     1561 tgatagagcc gtcttcatta taaggagtac ctaacggggt ggcaaacaat gctctttcca
     1621 aaacggcatt acgtgaattc ttgttggaga aagatgcctg aacattaata ccggcattaa
     1681 tccatttatt gatttcctga tctatacgga cacgggtaga gtacacttta tagtcatcat
     1741 tctcatacat actcttctca tcagtatagt tcaacgagaa ataagctttc gtcttctcag
     1801 tacctccggc aacggaaata ctataattct gcttcaaacc tgagtgtaat acttcatctc
     1861 cccaatttac ccattggttg tttttgatgg cgtcgtatct ttcaccgaaa atttcctcct
     1921 cattagtagt accgacaggc ttataagaat cttttatata attaatgtat gagtcacccg
     1981 tacgcatctt aggaacttta gctcctaaag tcgttccggc ataagcattg aaattgatga
     2041 ccggttttcc actcttggat cctttcgtag tcacgataat aacaccattc gcaccacttg
     2101 aaccgtagat agccgtagaa gatgcatctt tcagtacttc gatagattca atatcattgg
     2161 gattcaaggt agcaatatca cccggcatac catcgataat ataagtcggc ttaaatgcat
     2221 cggaagaaat attaccatcc tcatccaact gcaaagagcg ggtaccacgc aactgaactg
     2281 tcggtgacga acctgcctga cctgaagaat tagtgatatc cagacctgca attttacctt
     2341 gcagcgcatc catcggattc acgcccggat tcatggtgat atcctctgat ttcacagaag
     2401 caaccgcacc tgtcaaatca cgtttcttta ccgtaccgta accgatgacc actacctcat
     2461 ccaaagcctg tgtatccgga accatcttta tattcagcgg ggcatttccg ctcacaataa
     2521 tagcctgttc tttatatccg atataagaaa caaccagttc tttacttccg gccggaagat
     2581 taatggagaa cttaccgtca aaatcagtta tcgtacctgt acttgtacct ttcaccacaa
     2641 tagaaacacc gatcaacggt tctccatttt catctaaaac agttcctttc actgtctttg
     2701 tctgcatgac ggcttgcaca gtaatatcat tcacaccatt ttctgcataa acagatatgg
     2761 cagaaggggc acacaataaa gtcagcccta aaatcatgga aacgcgtcta tgctgtgtct
     2821 tccacgcttc aacaaatgca ttctctctca ttcgttttaa tttaaagtta atattaattt
     2881 tcctttgttt agtaaaatac aattagcata atcttttaca tagacgtttc cattttactt
     2941 ctgtactcac aaaggacgac aataatacaa aaattcgctt ttccaagcct ttttttcctc
     3001 aaatatatgc aaaggataaa aagacaaatt ttaggctaag ccaacaaatt ctctttttta
     3061 ttgttgaatg aagaataaaa agtgtaaatt tgtatttgga tgccacttaa actaacaaca
     3121 tattatcgcg gaaaagacat tcctgattta ccgggaacca atacttttca ttccaaggag
     3181 ttgtttcaga tctatgaatc gactccggga tataccccgc tactgatagt ggcaacagaa
     3241 gaaggcagac ctgtagcacg cctgcttgcc gccatacgca agaccaaaaa gtggcttccc
     3301 tcctctcttg tcaaacaatg tgtggtatat ggtgcaggtg aatttctgga cacttctcta
     3361 ccggcaagta aagagaagga ggaagaaatt ttcggtgaaa tgctggagca tctcgcacaa
     3421 gaagcatcac gtacctgcat tctcattgaa ttccgcaatc tggataattc catgttcggt
     3481 taccgtttct tccgaaagaa cgactttttt ccggtcaact ggctgcgtgt ccgtaactct
     3541 ctgcatagta cgcagaaagc ggaagaccgt ttcagcccgt cacgtatccg tcagatccgg
     3601 aaaggactca aaaacggagc caaagtagta gaagcccata cggtggaaga gattaaggaa
     3661 ttctcgcgga tgctgcacaa agtttattct tcacgaatac ggagatattt ccctgccaat
     3721 gactttttcc gccacatgaa cagcatgctt atcagaggaa aacaggcaaa aatattcatc
     3781 gtaaaataca aggaaaagat tatcggcggc tccgtctgca tctattccgg cgaaaatgct
     3841 tttatttggt tttcaggagg aatgcgaaag acgtatgcac tgcagtcacc cggcatactg
     3901 gcagtatgga aagcacttga agatgcccat gaacggggat tccgtcacat ggagttcatg
     3961 gatgtaggac ttcccttccg caaacatggt tatcgtgatt tcgtactccg tttcggaggc
     4021 aaacaaagca gtacccgccg ctggttccgt atcagctggc catggctgaa taatcttctg
     4081 gtcaagtttt atgtctaaat gtaatctcaa gattacaaaa cccgtctttg tcacccatcc
     4141 ggagcatttt ttatgcttta ttccccaata attaaatgca gaaatatttc tttattagac
     4201 aagaaatgtc tttctttgtg ctgttttatg ccatataagc acataattaa accatataaa
     4261 aaaatatagt tatgaagatt tcacacattg agcatcttgg cattgctgta aaaagcatcg
     4321 aagaagccct tccttactac gaaaacgtat tgggtctgaa atgttacaac atcgaaacag
     4381 tagaagatca aaaagtaaga accgcttttt taaaggtagg tgaaacaaaa atcgaattgt
     4441 tggagccgac ttgccccgaa agcaccattg ctaaatttat tgaaaacaaa ggtgcaggtg
     4501 ttcatcacgt agcatttgcc gtagaagatg gcgtagctaa tgctttggca gaagcagaaa
     4561 gcaaagaaat ccgtctgatt gacaaggctc cccgcaaagg tgccgaaggt ctgaacatcg
     4621 ctttccttca cccgaaatca acactgggtg tgctgacaga actctgcgaa cactaatcat
     4681 aaactctaaa aaaacaacaa gaactcatga gtaatcaact tgaaaaaatt aaagagctta
     4741 ttgaacgccg tgccgttgca cgcatcggag gcggcgaaaa agcaattgcg aagcaacatg
     4801 aaaaagggaa atacacagcg cgtgagcgta tagccatgct gttggatgaa ggtagcttcg
     4861 aagaaatgga catgttcgtt gagcacagat gcacgaactt cggcatggag aaaaagcact
     4921 atccgggtga tggtgtagta accggttgcg gtactatcga aggtcgtctc gtatatcttt
     4981 ttgcacagga ctttaccgtt actgcaggtt cactgtcgga aacaatgtca ctgaagatct
     5041 gtaagattat ggatcaggca atgaagatgg gtgctccttg tatcggtatc aatgactcgg
     5101 gcggtgcacg tatccaggaa ggtattaacg ctttggcagg ttacgcagaa atcttccagc
     5161 gcaatatcct cgcttcgggt gtcattccgc agatttccgg tatcttcggt ccttgtgccg
     5221 gcggtgctgt ttattctccg gcactgacag acttcacact gatgatggaa ggtacttctt
     5281 atatgttcct tacaggtccg aaagtagtga aaactgtaac cggtgaagac gtaagccagg
     5341 aaaacctcgg cggagcaagc gttcactcta ccaaatcggg tgttactcat ttcactgcca
     5401 aaacagaaga agaaggtctg gcgttgatcc gcacacttct gagctatatt cctcaaaaca
     5461 acctcgaaga agctccatac gtggattgca cagatccgat cgaccgtctg gaagactctc
     5521 tgaacgatat tattcccgac agccccaaca aaccgtatga tatgtacgaa gttatcagcg
     5581 ctatcgtgga caacggtgaa ttcctggaaa tccagaaaga ctatgccaag aatatcatta
     5641 tcggttttgc ccgtttcaac ggtcagtcgg taggtattgt agccaatcag cctaaattcc
     5701 ttgccggtgt actcgacagt aacgcatctc gcaaaggcgc acgtttcgtt cgtttctgcg
     5761 atgctttcaa tattcctatc gtatcgttgg tagacgtacc gggattcctt ccgggaacag
     5821 gtcaggaata caatggtgtc atccttcatg gtgccaaact gctgtatgct tacggtgaag
     5881 ctaccgtacc taaagtgaca atcacattgc gtaaatctta cggtggttct cacatcgtga
     5941 tgagctgtaa acaacttcgc ggtgatatga actatgcttg gcctacagct gaaatcgctg
     6001 taatgggtgg tgccggcgca gtagaagtat tgtacgcgcg tgaagccaaa gaccaggaaa
     6061 atccggctca gttccttgcc gaaaaagaag cagaatatac aaaactgttt gccaatcctt
     6121 ataatgcagc taagtatggt tacatcgatg atgtcatcga accgcgtaac acacgtttcc
     6181 gcgtgatccg tgctttgcag cagttgcaga ctaagaaact gtctaacccg gcgaagaaac
     6241 atggtaatat tccgttgtaa tccaactttt cacattaaaa caagaacgat tatgaacaaa
     6301 accaaaatcg gaatattcct ttctctgctg ttgctgattg gattgacttc ctgcggagag
     6361 caaaagtcga acaataagct attgctgaat gaagtcctga tagacaatca aaacaacttt
     6421 caggatgact acggcttgca cagtgcatgg attgaaatat tcaacaaatc atacggtagc
     6481 gcagacttag cagcttgttt attgaaagta agcagccagc cgggcgatac agtaacctat
     6541 tttatcccga aaggtgacat acttacatta gtaaagccac gccaacatgc gttattttgg
     6601 gcagacggcg aacctaatcg tggtaccttc cataccagct tcaaactgaa ccccgaaaca
     6661 gccaattggg tcggtctttt tgattcaggc agaaagctac tggatcaagt tgtcatacca
     6721 gcaggaactt taggtcccaa ccagtcttat gcacgcataa gtgatggagc agcagactgg
     6781 gaagtaaaag gcggaagcaa agataaatac gtaaccccga gcacgaacaa caaaaccctt
     6841 gacagtaatg ccaagatgga aaagttcgaa gaacatgact cagtcggtat cggtatgtct
     6901 atttcagcca tgagcgtagt attctgcgga ttgattcttc tcttcattgc cttcaaggtg
     6961 gtaggtaaag ttgctgtcaa cctgagcaaa cgcaatgcga tgaaggctaa aggcatcgat
     7021 aaagtcgaag cgaaagagct ttcacaggct ccgggtgaag tttatgctgc tatttcaatg
     7081 gcattacacg aaatgcagga tgaggtacac gacgtagaag aaacggtgct gaccatcact
     7141 cgtgtgaaac gcagttattc accgtggagt tcgaagattt acaccttgcg tgaaaatcct
     7201 aacagaaagt aaatcattcc ctaaaaagat aaaacgatga aagaatataa atataaaatc
     7261 aacggtaact catacaaagt aaccatcgga gatattgaag ataatatcgc tcatgtagaa
     7321 gtgaacggta cgcactacaa agtagaaatg gagaaacaac cgaaaactgc tcccaaaccg
     7381 gtagtagtac gtcctatgcc taactcaccg gctgctccta ccacaccggt agtgaaaccg
     7441 gctgctcctt ctaccggcaa atcgggcgtt aagtccccgc tgccaggcgt tatcctcgac
     7501 atcaaagtaa atgtaggcga tacagtgaag agaggacaga ctatcattat attggaagcc
     7561 atgaagatgg aaaacaatat caatgcggac aaagacggta aagtgactgc tatcaatgtc
     7621 aacaagggag attctgttct tgaaggtaat gacctcgtaa ttattgaata atatgggaga
     7681 ttttattagc tttttaggaa ataaccttgc cgacttctgg acctacacgg gatttgccaa
     7741 cgcgacaggt ggacatattg ctatgatcat tatcggttta ggctttattt acttagctgt
     7801 agccaaagag ttcgagccga tgttgttaat tcctatcgga ttcggtattc tgatcggtaa
     7861 tatacctttc aatatggacg ccggactaaa agtcggtata tatgaagaag gttctgtatt
     7921 gaacatattg tatcagggag taacgtccgg ctggtatcca ccgctcatct tcttaggtat
     7981 cggtgccatg acagacttct cggcgctgat ctccaatccg aagctgatgc tgatcggtgc
     8041 ggctgcccag tttggtatct tcggtgcata catgattgca ttggaaatgg gatttgaccc
     8101 gatgcaggcc ggtgctatcg gtatcatcgg tggagcagat ggtccgacgg ctatcttcct
     8161 ttcgtccaag ctggcaccta acttaatggg agccattgcg gtatccgcct actcttatat
     8221 ggcgttagtt ccggtgatac agccgcctat catgcgtctg ctcaccacca agcacgaacg
     8281 cgttatccgt atgaaaccgc cacgtgccgt ttctcataca gagaaagtga ttttcccgat
     8341 tatcggtctg ttgctgacct gcttcctggt tccttccggt ctacctctgc tgggtatgct
     8401 gttcttcggt aacctgttga aagaaagtgg tgtaacccgt cgtctggcta acacagccag
     8461 cggtccgctg attgacacaa tcactatcct gttaggtttg accgtaggtg cttctactca
     8521 ggcttctgag ttcctgacac tcgactccat caagatcttc gccctcggtg ctttgtcatt
     8581 tatcattgct accgcatcag gtgtgatctt cgttaagatc ttcaacctct tcctcaagaa
     8641 gggcaataag atcaatccgt tgatcggtaa tgcaggtgta tctgccgttc ccgactctgc
     8701 acgtatctca caagttgtcg gtctggaata tgatcctacc aactacttgc tgatgcacgc
     8761 tatgggtccg aacgtagcag gtgtaatcgg ttcggctgtt gctgccggta tcctgttagg
     8821 attcttaatg tagggacaag gtgcccctgt caggtttcca ttcggaatgc cgggacaaaa
     8881 tattaggtgc ggatattgct gttttagatg caatatccgc acttatcatt atgttatctt
     8941 ctcttatcat tccgttaatc tattccaaaa aggctacgaa taattcgtaa atacgatatt
     9001 ttttagcatc ttgcgtcttt gttacgacac actaaaataa atatttatga aacggattat
     9061 tctcctcgcc ttcctttgta ccaccaccct ggtgatggcg cagcgcatca atcatgttca
     9121 ggaagcaata gcaaactacg attacgaggc agctctcact ctcattgcca aagaaaagcc
     9181 gacaattccc ctactcttgc aaaaaggtaa agcacaacgg ggacttggga tgaatacaga
     9241 agcactttcc acttatcagg aaatcataac caatgacact gccaataccc gtgcatatat
     9301 cgaagcagcc gaatgctgcc gttcattggc caaataccaa caggcactga aatattatga
     9361 acaggcactt gatctgaatc cggaaaacaa atatgtgcgt attcaataca tcggactact
     9421 gctctcttta cagaagtttc aggatgcttt aggagaaagt agtctgatga cagagaaaga
     9481 cagttccgcc atcgccttgc atctgcaggc ccaaagtttc gaaggtatgg gagagcttct
     9541 ccccgccacg gggtgctact ataatataca ggagaaatac cccgacgact atcttgccgc
     9601 cgccaagctc gccgcactga acatagccgg ttcttatttc aacgaagcaa ttgaagccac
     9661 ggagaaatat cggcagattg acaccaccaa catcgctgtc aaccgccaga atgcactggc
     9721 atattgtctg aataaggatt atcctaccgc tatccagcgt tatgaatacc tggtgagcca
     9781 gggcgacagt tcttttcata cctgttatta tctgggtatc agctattatg cggaagagaa
     9841 atattacgaa gcacatgact ttctggaagc cgcccgaaaa catgatcctg aaaacgtaaa
     9901 cctgctttat tatctcggcc gtgcctgcgc caagacttca tggaagaagt taggcgtaga
     9961 gtatctcgaa aaagcgcttg atctgactat tcccaaagac agtaatatgg tacggctcta
    10021 tattggcatg accgactgct acaaaatggc acagatgcct aaagagcaga ttgaatcgat
    10081 cagagaacgc taccggaaat acgataaaca aaatcataag ctgctctatg atatggcttt
    10141 catttatttc tattcgctga aagacaagaa aaacaccgaa cgctgtctgg aagcattctt
    10201 aaaaacacgc ccgaaagaag ataaggaaga agaagcgaaa ctaaacgaac gaggcgaact
    10261 cgttttaggc actaagaatt attataatgc tgcagccaac tggctgaaag acattcaaag
    10321 taagcaaaag atagaagatt tcttcttggg aggaaatgtg cccgctcaga aaccggaata
    10381 agcagataaa ggatattacg taaaaaaggc tgcaaccgtc aaacgattgc agcctttcta
    10441 tataatagga taatctgtga ttattcagcc aatttgttgt ctgaacccag cacattaagg
    10501 attttgtgct tgtacagttt ttccatgttg tcacgagccg gaccaagata cttacgtggg
    10561 tcgaattcag ctggtttttc agcgaaagtc ttacggatag cagcagtcat agccagacga
    10621 gagtctgagt cgatgttgat tttgcaaaca gcagacttgg cagctttacg caattcttct
    10681 tcaggaatac cgatagcagc tttcagagca ccaccaaact tgttgattgt ttcaacttct
    10741 tcttcaggaa ctgaagatga tccgtgaagt acgataggga atcccggaag tttttccatt
    10801 acagcatcca atacttcgaa agccaatgga ggaggaacca tacgaccggt agccggatcg
    10861 atgtggcact gttccggagt aaacttgtaa gcaccgtgag aagtaccgat agagatagcc
    10921 aatgagtcac aacctgtacg agtagcgaaa tcaattactt cttcagggtc agtgtatgtg
    10981 tggtggtcag aagaaacttc atcttctaca cctgccaata caccaagttc accttcaact
    11041 gttacgtcga actgatgagc gtattcaaca accttcttag tcaaagcaac gttttcttcg
    11101 taaggaagat gagaaccgtc gatcataact gaagagaaac ctgaatcgat gcaagatttg
    11161 caagtttcaa aagtatctcc gtggtcaagg tgaagaacga tttcaggatg tgcgcaacct
    11221 aattcctttg cgtattctac agcaccctga gccatgtaac gcaacaaagt agcgttagca
    11281 tactgacgag cacctttaga aacctgaaga atcaccggag attttgtttc tactgcagcc
    11341 ttgatgatag cctgcatctg ttccatattg ttgaagttga atgctgggat agcgtatcca
    11401 cccttaatag ccttagcaaa catgtctctt gtgtttacca atcctaagtc tttgtaatta
    11461 accattttgt ttaaagttta ttgttagtga attaaaattc tacgcaaaag taagcattat
    11521 ccaccgaata acgagcatcg gaaagaaaaa tataatagaa aaaggtttaa atcgatcagc
    11581 aaatattcat ccgtaagcgg gtctgacatt agattgtaat gtccacctag caaataaacg
    11641 gctgaaaggt tctatcccaa aacaggtatt ataccataaa aagcacaaga cattcttttc
    11701 gtgccaatca tataattcat agaaatagca taattcacag aagttttttc agcaaagctt
    11761 tttctatttc ggagaaatgt gctatctttg cgctctgaaa atgaccatta cactatttct
    11821 taccaaaata gtaacagaat ataaattaaa aaaacagata ctgaaatgaa aaaaggcctt
    11881 catccagaat cataccgtcc ggtagtattc aaagatatgt caaatggtga tatgtttttg
    11941 tctaaatcaa ctgtagcaac taaagaaacc atcgaattcg aaggtgaaac ttatccgttg
    12001 ctgaagattg aaatctctaa cacttctcac ccgttctata caggtaaatc tacattggta
    12061 gatactgcag gtcgcgttga taagttcatg agccgttacg gtgaccgtaa gaagaaataa
    12121 ttcaatcttt cgttaagatg aaaaaagagg agatttccgg ttggaaattt cctctttttc
    12181 gtttcataga taaactaaag gaccgcacca ttcttcacag agtagtgcgg tccgtatatt
    12241 acctggctaa ggggaactat taccaggtaa tataaaaatg gtagagttaa gggaagatac
    12301 cataccatta tattgtctga tctccgtaaa actgatggtc tatta
//
